V. Dijkstra-Muncan PhD publications

2021

• Westendorp Florien, Karpus Olga N., Koelink Pim J., Vermeulen Jacqueline L. M., Meisner Sander, Koster Jan, Büller Nikè V. J. A., Wildenberg Manon E., Muncan Vanesa, van den Brink Gijs R. Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation Oncogene 2021 [PubMed]

2020

• Roodsant Thomas, Navis Marit, Aknouch Ikrame, Renes Ingrid B., van Elburg Ruurd M., Pajkrt Dasja, Wolthers Katja C., Schultsz Constance, van der Ark Kees C. H., Sridhar Adithya, Muncan Vanesa A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine Frontiers in cellular and infection microbiology 2020;10 [PubMed]
• Montenegro-Miranda Paula S., van der Meer Jonathan H. M., Jones Christine, Meisner Sander, Vermeulen Jacqueline L. M., Koster Jan, Wildenberg Manon E., Heijmans Jarom, Boudreau Francois, Ribeiro Agnes, van den Brink Gijs R., Muncan Vanesa A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration Cellular and molecular gastroenterology and hepatology 2020;10 (2):209-223 [PubMed]
• Meijer Bartolomeus J., Giugliano Francesca P., Baan Bart, van der Meer Jonathan H. M., Meisner Sander, van Roest Manon, Koelink Pim J., de Boer Ruben J., Jones Nic, Breitwieser Wolfgang, van der Wel Nicole N., Wildenberg Manon E., van den Brink Gijs R., Heijmans Jarom, Muncan Vanesa ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair Cellular and molecular gastroenterology and hepatology 2020;10 (1):23-42 [PubMed]
• Navis Marit, Muncan Vanesa, Sangild Per Torp, Willumsen Line M. ller, Koelink Pim J., Wildenberg Manon E., Abrahamse Evan, Thymann Thomas, Elburg Ruurd M. Van, Renes Ingrid B. Beneficial effect of mildly pasteurized whey protein on intestinal integrity and innate defense in preterm and near-term piglets Nutrients 2020;12 (4) [PubMed]
• Smit Wouter Laurentius, Spaan Claudia Nanette, de Boer Ruben Johannes, Ramesh Prashanthi, Garcia T. nia Martins, Meijer Bartolomeus Joannes, Vermeulen Jacqueline Ludovicus Maria, Lezzerini Marco, MacInnes Alyson Winfried, Koster Jan, Medema Jan Paul, van den Brink Gijs Robert, Muncan Vanesa, Heijmans Jarom Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity Proceedings of the National Academy of Sciences of the United States of America 2020;117 (41):25560-25570 [PubMed]
• Meijer Bartolomeus J. Maintenance and disruption of intestinal epithelial homeostasis 2020. 189p. ISBN 9789493197152. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van den Brink Gijs R.; Co-supervisors: Muncan Vanesa, Heijmans Jarom)
• Pereira Bruno, Amaral Ana L., Dias Alexandre, Mendes Nuno, Muncan Vanesa, Silva Ana R., Thibert Chantal, Radu Anca G., David Leonor, Máximo Valdemar, van den Brink Gijs R., Billaud Marc, Almeida Raquel MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium EMBO reports 2020;21 (4) [PubMed]
• Navis Marit, Schwebel Lauriane, Kappel Susanne Soendergaard, Muncan Vanesa, Sangild Per Torp, Abrahamse Evan, Aunsholt Lise, Thymann Thomas, van Elburg Ruurd M., Renes Ingrid B. Mildly pasteurized whey protein promotes gut tolerance in immature piglets compared with extensively heated whey protein Nutrients 2020;12 (11):1-19 [PubMed]

2019

• Karpus Olga N, Westendorp B Florien, Vermeulen Jacqueline L M, Meisner Sander, Koster Jan, Muncan Vanesa, Wildenberg Manon E, van den Brink Gijs R Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth Cell reports 2019;26 (13):3698-3708.e5 [PubMed]
• Spaan Claudia N., Smit Wouter L., van Lidth de Jeude Jooske F., Meijer Bartolomeus J., Muncan Vanesa, van den Brink Gijs R., Heijmans Jarom Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling Cell death & disease 2019;10 (7) [PubMed]
• Navis Marit, Martins Garcia T. nia, Renes Ingrid B., Vermeulen Jacqueline L. M., Meisner Sander, Wildenberg Manon E., van den Brink Gijs R., van Elburg Ruurd M., Muncan Vanesa Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning EMBO reports 2019;20 (2) [PubMed]
• Garcia T. nia Martins, Navis Marit, Wildenberg Manon E., van Elburg Ruurd M., Muncan Vanesa Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids Journal of visualized experiments 2019 (153) [PubMed]
• Naik Jyoti, Hau Chi M., Bloemendaal Lysbeth ten, Mok Kam S., Hajji Najat, Wehman Ann M., Meisner Sander, Muncan Vanesa, Paauw Nanne J., de Vries H. E., Nieuwland Rienk, Paulusma Coen C., Bosma Piter J. The P4-ATPase ATP9A is a novel determinant of exosome release PLoS ONE 2019;14 (4) [PubMed]

2018

• Meijer Bartolomeus J., Wielenga Mattheus C. B., Hoyer Patricia B., Amos-Landgraf James M., Hakvoort Theodorus B. M., Muncan Vanesa, Heijmans Jarom, van den Brink Gijs R. Colorectal tumor prevention by the progestin medroxyprogesterone acetate is critically dependent on postmenopausal status Oncotarget 2018;9 (55):30561-30567 [PubMed]
• Muncan Vanesa, Sansom Owen J., Tertoolen Leon, Phesse Toby J., Begthel Harry, Sancho Elena, Cole Alicia M., Gregorieff Alex, Moreno de Alboran Ignacio, Clevers Hans, Clarke Alan R. Erratum: Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc" (Molecular and cellular biology (2006) 26 22 (8418-8426) PII: e00482-18) Molecular and cellular biology 2018;38 (24) [PubMed]
• de Bruyn Jessica R., van den Brink Gijs R., Steenkamer Jessica, Buskens Christianne J., Bemelman Willem A., Meisner Sander, Muncan Vanesa, te Velde Anje A., D'Haens Geert R., Wildenberg Manon E. Fibrostenotic phenotype of myofibroblasts in crohn's disease is dependent on tissue stiffness and reversed by LOX inhibition Journal of Crohn s & colitis 2018;12 (7):849-859 [PubMed]
• van Lidth de Jeude Jooske F., Spaan Claudia N., Meijer Bartolomeus J., Smit Wouter L., Soeratram Tanya T. D., Wielenga Mattheus C. B., Florien Westendorp B., Lee Amy S., Meisner Sander, Vermeulen Jacqueline L. M., Wildenberg Manon E., van den Brink Gijs R., Muncan Vanesa, Heijmans Jarom Heterozygosity of chaperone GRP78 reduces intestinal stem cell regeneration potential and protects against adenoma formation Cancer research 2018;78 (21):6098-6106 [PubMed]
• Westendorp B. Florien, Büller Nikè V. J. A., Karpus Olga N., van Dop Willemijn A., Koster Jan, Versteeg Rogier, Koelink Pim J., Snel Clinton Y., Meisner Sander, Roelofs Joris J. T. H., Uhmann Anja, Ver Loren van Themaat Emiel, Heijmans Jarom, Hahn Heidi, Muncan Vanesa, Wildenberg Manon E., van den Brink Gijs R. Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response Cellular and molecular gastroenterology and hepatology 2018;5 (1):67-82.e1 [PubMed]
• van Lidth de Jeude Jooske F. The unfolded protein response in intestinal stem cells: A focus on cancer 2018. ISBN 9789402811193. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van den Brink G. R.; Co-supervisors: Heijmans J., Muncan V.)

2017

• van Lidth de Jeude J. F. , Meijer B. J., Wielenga M. C. B., Spaan C. N., Baan B., Rosekrans S. L., Meisner S., Shen Y. H., Lee A. S., Paton J. C., Paton A. W., Muncan V., van den Brink G. R., Heijmans J. Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells Oncogene 2017;36 (24):3397-3405 [PubMed]

2016

• Wielenga Mattheus C. B. Between cancer and therapy: Studies of the colon 2016. 153p. ISBN 9789462599734. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Heijmans J., Muncan V.)
• Turfkruyer M., Rekima A., Macchiaverni P., Le Bourhis L., Muncan V., van den Brink G. R., Tulic M. K., Verhasselt V. Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency Mucosal immunology 2016;9 (2):479-491 [PubMed]
• Schilderink Ronald, Verseijden Caroline, Seppen Jurgen, Muncan Vanesa, van den Brink Gijs R., Lambers Tim T., van Tol Eric A., de Jonge Wouter J. The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC American journal of physiology. Gastrointestinal and liver physiology 2016;310 (11):G1138-G1146 [PubMed]

2015

• Rosekrans Sanne L., Heijmans Jarom, Büller Nikè V. J. A., Westerlund Jessica, Lee Amy S., Muncan Vanesa, van den Brink Gijs R. ER stress induces epithelial differentiation in the mouse oesophagus Gut 2015;64 (2):195-202 [PubMed]
• Rosekrans Sanne L., Baan Bart, Muncan Vanesa, van den Brink Gijs R. Esophageal development and epithelial homeostasis American journal of physiology. Gastrointestinal and liver physiology 2015;309 (4):G216-G228 [PubMed]
• Rosekrans Sanne Liesbeth Homeostasis of the esophageal epithelium: A quest for the stem cell 2015. 147p. ISBN 9789462596573. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van den Brink G. R.; Co-supervisors: Muncan V., Heijmans J.)
• Büller Nike Vittoria Justitia Anna Intestinal Hedgehog signaling in tumors and inflammation 2015. 162p. ISBN 9789462596290. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van den Brink G. R.; Co-supervisors: Muncan V., Wildenberg M. E.)
• Büller Nikè V. J. A., Rosekrans Sanne L., Metcalfe Ciara, Heijmans Jarom, van Dop Willemijn A., Fessler Evelyn, Jansen Marnix, Ahn Christina, Vermeulen Jacqueline L. M., Westendorp B. Florien, Robanus-Maandag Els C., Offerhaus G. Johan, Medema Jan Paul, D'Haens Geert R. A. M., Wildenberg Manon E., de Sauvage Frederic J., Muncan Vanesa, van den Brink Gijs R. Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice Gastroenterology 2015;148 (1):170-180.e6 [PubMed]

2014

• Wielenga Mattheus C. B., van Lidth de Jeude Jooske F., Rosekrans Sanne L., Levin Alon D., Schukking Monique, D'Haens Geert R. A. M., Heijmans Jarom, Jansen Marnix, Muncan Vanesa, van den Brink Gijs R. Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis World journal of gastroenterology 2014;20 (44):16683-16689 [PubMed]
• Verhaar Auke P., Hoekstra Elmer, Tjon Angela S. W., Utomo Wesley K., Deuring J. Jasper, Bakker Elvira R. M., Muncan Vanesa, Peppelenbosch Maikel P. Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity Scientific reports 2014;4:5468 [PubMed]
• Phesse T. J., Myant K. B., Cole A. M., Ridgway R. A., Pearson H., Muncan V., van den Brink G. R., Vousden K. H., Sears R., Vassilev L. T., Clarke A. R., Sansom O. J. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo Cell death and differentiation 2014;21 (6):956-966 [PubMed]
• Heijmans Jarom, Wielenga Mattheus C. B., Rosekrans Sanne Liesbeth, van Lidth de Jeude Jooske F., Roelofs Joris, Groothuis Patrick, Ederveen Antwan, de Jonge-Muller Eveline S. M., Biemond Izak, Hardwick James C. H., D'Haens Geert, Hommes Daniel W., Muncan Vanesa, van den Brink Gijs R. Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer Gut 2014;63 (2):310-316 [PubMed]
• Amos-Landgraf James M., Heijmans Jarom, Wielenga Mattheus C. B., Dunkin Elisa, Krentz Kathy J., Clipson Linda, Ederveen Antwan G., Groothuis Patrick G., Mosselman Sietse, Muncan Vanesa, Hommes Daniel W., Shedlovsky Alexandra, Dove William F., van den Brink Gijs R. Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones Proceedings of the National Academy of Sciences of the United States of America 2014;111 (46):16514-16519 [PubMed]

2013

• Heijmans Jarom A close-up of colon cancer 2013. 209p. ISBN 9789090277530. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van den Brink G. R., Hommes D. W.; Co-supervisor: Muncan V.)
• Heijmans Jarom, van Lidth de Jeude Jooske F., Koo Bon-Kyoung, Rosekrans Sanne L., Wielenga Mattheus C. B., van de Wetering Marc, Ferrante Marc, Lee Amy S., Onderwater Jos J. M., Paton James C., Paton Adrienne W., Mommaas A. Mieke, Kodach Liudmila L., Hardwick James C., Hommes Daniël W., Clevers Hans, Muncan Vanesa, van den Brink Gijs R. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response Cell reports 2013;3 (4):1128-1139 [PubMed]
• Heijmans J., Büller N. V. J. A., Hoff E., Dihal A. A., van der Poll T., van Zoelen M. A. D., Bierhaus A., Biemond I., Hardwick J. C. H., Hommes D. W., Muncan V., van den Brink G. R. Rage signalling promotes intestinal tumourigenesis Oncogene 2013;32 (9):1202-1206 [PubMed]

2012

• Baan Bart, Dihal Ashwin A., Hoff Eva, Bos Carina L., Voorneveld Philip W., Koelink Pim J., Wildenberg Manon E., Muncan Vanesa, Heijmans Jarom, Verspaget Hein W., Richel Dick J., Hardwick James C. H., Hommes Daniel W., Peppelenbosch Maikel P., van den Brink Gijs R. 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer Gut 2012;61 (12):1708-1715 [PubMed]
• tee Jin-Ming, Sartori da Silva Maria A., Rygiel Agnieszka M., Muncan Vanesa, Bink Robert, van den Brink Gijs R., van Tijn Paula, Zivkovic Danica, Kodach Liudmila L., Guardavaccaro Daniele, Diks Sander H., Peppelenbosch Maikel P. asb11 is a regulator of embryonic and adult regenerative myogenesis Stem cells and development 2012;21 (17):3091-3103 [PubMed]
• Heijmans Jarom, Büller Nikè V. J. A., Muncan Vanesa, van den Brink Gijs R. Rage mediated DAMP signaling in intestinal tumorigenesis Oncoimmunology 2012;1 (7):1165-1166 [PubMed]
• Heijmans J., Büller N. V., Muncan V., van den Brink G. R. Role of mast cells in colorectal cancer development, the jury is still out BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (1):9-13 [PubMed]

2011

• Muncan Vanesa, Heijmans Jarom, Krasinski Stephen D., Büller Nikè V., Wildenberg Manon E., Meisner Sander, Radonjic Marijana, Stapleton Kelly A., Lamers Wout H., Biemond Izak, van den Bergh Weerman Marius A., O'Carroll Dónal, Hardwick James C., Hommes Daniel W., van den Brink Gijs R. Blimp1 regulates the transition of neonatal to adult intestinal epithelium Nature communications 2011;2:452 [PubMed]
• Heijmans Jarom, Muncan Vanesa, Jacobs Rutger J., de Jonge-Muller Eveline S. M., Graven Laura, Biemond Izak, Ederveen Antwan G., Groothuis Patrick G., Mosselman Sietse, Hardwick James C., Hommes Daniel W., van den Brink Gijs R. Intestinal tumorigenesis is not affected by progesterone signaling in rodent models PLoS ONE 2011;6 (7):e22620 [PubMed]

2010

• Cole Alicia M., Myant Kevin, Reed Karen R., Ridgway Rachel A., Athineos Dimitris, van den Brink Gijs R., Muncan Vanesa, Clevers Hans, Clarke Alan R., Sicinski Peter, Sansom Owen J. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss Cancer research 2010;70 (20):8149-8158 [PubMed]
• Ashton Gabrielle H., Morton Jennifer P., Myant Kevin, Phesse Toby J., Ridgway Rachel A., Marsh Victoria, Wilkins Julie A., Athineos Dimitris, Muncan Vanesa, Kemp Richard, Neufeld Kristi, Clevers Hans, Brunton Valerie, Winton Douglas J., Wang Xiaoyan, Sears Rosalie C., Clarke Alan R., Frame Margaret C., Sansom Owen J. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling Developmental cell 2010;19 (2):259-269 [PubMed]

2008

• Reed Karen R., Athineos Dimitris, Meniel Valerie S., Wilkins Julie A., Ridgway Rachel A., Burke Zoé D., Muncan Vanesa, Clarke Alan R., Sansom Owen J. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver Proceedings of the National Academy of Sciences of the United States of America 2008;105 (48):18919-18923 [PubMed]

2007

• Sansom Owen J., Meniel Valerie S., Muncan Vanesa, Phesse Toby J., Wilkins Julie A., Reed Karen R., Vass J. Keith, Athineos Dimitris, Clevers Hans, Clarke Alan R. Myc deletion rescues Apc deficiency in the small intestine Nature 2007;446 (7136):676-679 [PubMed]
• Muncan Vanesa, Faro Ana, Haramis Anna-Pavlina G., Hurlstone Adam F. L., Wienholds Erno, van Es Johan, Korving Jeroen, Begthel Harry, Zivkovic Danica, Clevers Hans T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine EMBO reports 2007;8 (10):966-973 [PubMed]

2006

• Muncan Vanesa, Sansom Owen J., Tertoolen Leon, Phesse Toby J., Begthel Harry, Sancho Elena, Cole Alicia M., Gregorieff Alex, de Alboran Ignacio Moreno, Clevers Hans, Clarke Alan R. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc Molecular and cellular biology 2006;26 (22):8418-8426 [PubMed]

2005

• Sansom Owen J., Reed Karen R., van de Wetering Marc, Muncan Vanesa, Winton Douglas J., Clevers Hans, Clarke Alan R. Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine Journal of biological chemistry 2005;280 (31):28463-28467 [PubMed]

2003

• van de Wetering Marc, Oving Irma, Muncan Vanesa, Pon Fong Menno Tjon, Brantjes Helen, van Leenen Dik, Holstege Frank C. P., Brummelkamp Thijn R., Agami Reuven, Clevers Hans Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector EMBO reports 2003;4 (6):609-615 [PubMed]

2002

• Kuzmenkin Alexey, Muncan Vanesa, Jurkat-Rott Karin, Hang Chao, Lerche Holger, Lehmann-Horn Frank, Mitrovic Nenad Enhanced inactivation and pH sensitivity of Na(+) channel mutations causing hypokalaemic periodic paralysis type II Brain 2002;125 (Part 4):835-843 [PubMed]