The mission of the department of Nephrology is to improve the renal and cardiovascular outcome of chronic kidney disease as well as the results of renal replacement therapy.
To achieve this, not only clinical studies, but also fundamental studies on pathofysiological processes are relevant. The research lines are focussed on renal physiology, dialysis and renal transplantation. The projects include studies in patients, in animals and in cell cultures.
Transplantation Immunology
This theme is embedded in the theme on Infection and Immunity (PI: Prof. Dr. R.J.M. ten Berge).
In patients who have received a renal transplant, studies are performed on the mechanism of action of immunosuppressive drug therapy. Treatment with immunosuppressive drugs may be complicated by viral infections such as cytomegalovirus (CMV) and BK virus (BKV) infection. Study of the immune response to CMV and BKV infection in these immuno-compromised patients provides insights which are also applicable to patients who are immuno-compromised for other reasons than receiving a solid organ allograft.In short, our programme consists of the following research lines:Group Members:Dr. F.J. Bemelman MD PhD
Dr. K.M. Heutinck MSc
Drs. M.C. van Aalderen MD
Drs. S.H.C. Havenith MD
E.B.M. Remmerswaal
Drs G.H. Struijk MD
Drs. K.A.M.I. van Donselaar MD
S.L. YongSelected Publications:ContactProf.dr. R.J.M. ten Berge
Department of Internal Medicine,
AMC, F4 - 215
Phone:
+31 020 - 566 5990
Fax:
+31 020 - 691 4904
E-mail:
r.j.tenberge@amc.uva.nl
Renal Physiology
This theme focuses on chronic kidney disease (CKD) and renovascular diseases.
The presence of volume overload, disturbances of electrolyte homeostasis as well as sympathetic nervous hyperactivitiy hallmarks chronic renal failure, as well as hypertension, and is recognized as an important pathophysiological factor in cardiovascular and renal outcome. In collaboration with the Hypertension Group of the Department of Vascular Medicine, both clinical and animals studies are performed. Our methodological arsenal comprises gold standard measurements of GFR, ERPF, extracellular volume, glycocalyx mass, as well as analysis of the central blood pressure and pulse wave contours, and renal sympathetic nerve denervation.
In short, our programme consists of the following research lines:Group Members:
Dr. L. Vogt MD PhD
Dr. C.T.P. Krediet MD PhD
Prof. dr. J.J. Homan van der Heide MD PhD
Drs. L. Dobrowolski MDCollaboration with Hypertension group (Dept. Vascular Medicine):
Dr. B.J.H. van den Born MD PhD
Drs. D. Eeftinck Schattenkerk MD
Drs. F. Amraoui MD
Selected Publications:ContactDr. L. Vogt
Department of Internal Medicine,
AMC, F4 - 215
Phone:
+31 020 - 566 5990
Fax:
+31 020 - 691 4904
E-mail:
l.vogt@amc.nl
Peritoneal- and hemodialysis
This theme focuses on cardiovascular and infectious complications of dialysis treatmentGroup members:
Dr. D.G. Struijk MD PhD
Prof. dr. R.T. Krediet MD PhD emeritus professor
Drs C. Vlahu MD
Drs S. van Esch MD
Drs D. Lopes-Bareto
Drs M. de GraaffSelected publications:ContactDr. D.G. Struijk
Department of Internal Medicine,
AMC, A01-136
Phone:
+31 020 - 566 9111
Fax:
+31 020 - 696 9202 /
+31 020 - 566 9588
E-mail:
d.g.struijk@amc.uva.nl