M. Riool PhD

Other Academic Staff
Main activities
Education, Research
Experimental bacteriology
Focus of research

Biomaterial-associated infections and novel antimicrobial strategies


Infections of biomedical devices, or “biomaterials” (catheters, prosthetic heart valves, implants), are a major and increasing problem in modern medicine, especially in view of the increase in antibiotic resistance. We have discovered that bacteria do not only colonize the medical device by biofilm-formation, but also persist in surrounding tissue, due to disturbed local immunity. Bacterial, biomaterial, and host-responses involved in the pathogenesis are subject of studies, in order to find novel approaches for treatment and prevention.

Previously involved in the Dutch NANTICO (Non-adherent ANTImicrobial Coatings) consortium, focused on the development of different antimicrobial coating strategies to prevent biomaterial-associated infections, and in the European FP7 project Biofilm Alliance (BALI), where we developed novel Synthetic Antimicrobial and Anti-biofilm Peptides.

Currently involved in the STW project CRANIOSAFE, aiming to develop innovative antimicrobial materials for skull reconstructions, and the NEWPOL project SuperActiv, developing supramolecular biomaterials with antimicrobial and regenerative activity.


Key publications
  • de Breij Anna, Riool Martijn, Cordfunke Robert A., Malanovic Nermina, de Boer Leonie, Koning Roman I., Ravensbergen Elisabeth, Franken Marnix, van der Heijde Tobias, Boekema Bouke K., Kwakman Paulus H. S., Kamp Niels, El Ghalbzouri Abdelouahab, Lohner Karl, Zaat Sebastian A. J., Drijfhout Jan W., Nibbering Peter H. The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms Science translational medicine 2018;10 (423):eaan4044 [PubMed]
  • Riool Martijn, de Breij Anna, de Boer Leonie, Kwakman Paulus H. S., Cordfunke Robert A., Cohen Or, Malanovic Nermina, Emanuel Noam, Lohner Karl, Drijfhout Jan W., Nibbering Peter H., Zaat Sebastian A. J. Controlled Release of LL-37-Derived Synthetic Antimicrobial and Anti-Biofilm Peptides SAAP-145 and SAAP-276 Prevents Experimental Biomaterial-Associated Staphylococcus aureus Infection Advanced functional materials 2017;27 (20):1606623
  • Riool M., Dirks A. J., Jaspers V., de Boer L., Loontjens T. J., van der Loos C. M., Florquin S., Apachitei I., Rijk L. N., Keul H. A., Zaat S. A. A chlorhexidine-releasing epoxy-based coating on titanium implants prevents Staphylococcus aureus experimental biomaterial-associated infection European cells & materials 2017;33:143-157 [PubMed]
  • Zaat S. A. J., Broekhuizen C. A. N., Riool M. Host tissue as a niche for biomaterial-associated infection Future microbiology 2010;5 (8):1149-1151 [PubMed]
  • Riool Martijn, de Boer Leonie, Jaspers Valery, van der Loos Chris M., van Wamel Willem J. B., Wu Gang, Kwakman Paulus H. S., Zaat Sebastian A. J. Staphylococcus epidermidis originating from titanium implants infects surrounding tissue and immune cells Acta biomaterialia 2014;10 (12):5202-5212 [PubMed]
  • Riool Martijn, de Breij Anna, Drijfhout Jan W., Nibbering Peter H., Zaat Sebastian A. J. Antimicrobial Peptides in Biomedical Device Manufacturing Frontiers in chemistry 2017;5:63 [PubMed]
All Publications
Research programmes

S.A.J. Zaat PhD (Biomaterial-associated infections and novel antimicrobial strategies)