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MD PhD S.W. Tas

Position
Medical Specialist
Main activities
Patient care, Research
Specialisation
Internal Medicine-Rheumatology
Focus of research

The molecular regulation of inflammation, in particular the role of NF-κB signaling and angiogenesis in immune-mediated inflammatory diseases. Projects integrate basic immunological experiments, novel techniques and sampling of multiple tissues (translational medicine). Ultimate goals include development of new treatment strategies targeting (non-canonical) NF-κB signaling for immune-mediated inflammatory diseases (IMIDs).

Keywords: rheumatoid arthritis, synovial inflammation, dendritic cells, immune regulation, NF-κB signaling, gene therapy, angiogenesis, rare IMIDs (including vasculitis).

Key publications
  • Tas Sander W., Maracle Chrissta X., Balogh Emese, Szekanecz Zoltán Targeting of proangiogenic signalling pathways in chronic inflammation Nature reviews. Rheumatology 2016;12 (2):111-122 [PubMed]
  • Noort Ae R., van Zoest Katinka P. M., van Baarsen Lisa G., Maracle Chrissta X., Helder Boy, Papazian Natalie, Romera-Hernandez Monica, Tak Paul P., Cupedo Tom, Tas Sander W. Tertiary Lymphoid Structures in Rheumatoid Arthritis: NF-κB-Inducing Kinase-Positive Endothelial Cells as Central Players American journal of pathology 2015;185 (7):1935-1943 [PubMed]
  • Noort Ae R., van Zoest Katinka P. M., Weijers Ester M., Koolwijk Pieter, Maracle Chrissta X., Novack Deborah V., Siemerink Martin J., Schlingemann Reinier O., Tak Paul P., Tas Sander W. NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis Journal of pathology 2014;234 (3):375-385 [PubMed]
  • Noort Ae R., Tak Paul P., Tas Sander W. Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? Arthritis research & therapy 2015;17 (1):15 [PubMed]
  • Maijer Karen I., Noort Ae Ri, de Hair Maria J. H., van der Leij Christiaan, van Zoest Katinka P. M., Choi Ivy Y., Gerlag Daniëlle M., Maas Mario, Tak Paul P., Tas Sander W. Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study Journal of rheumatology 2015;42 (9):1573-1581 [PubMed]
All Publications
Curriculum Vitae

Education and Qualifications:

2015 BKO certification (education qualification)
2013 EULAR Sonography course
2013 BROK course (clinical trial licence)
2011 Rheumatologist & Internist
2007 SMBWO-Immunologist
2006 Doctor of Philosophy (Ph.D.) Medicine (University of Amsterdam)
2003 Advanced Immunology Course (University of Amsterdam)
2002 Animal Experiments License (University of Amsterdam)
2001 Medical Doctor (M.D.) cum laude (Leiden University)
1998 Harvard University, Boston, MA, USA: Radiation Protection in Research
1994 Secondary School, Gymnasium-β (Bonaventuracollege, Leiden)

Work and Research Experience:

2016- Editorial Board member for Rheumatology and Arthritis Research & Therapy
2016- Member of Scientific Advisory Board Dutch Arthritis Foundation
2013- Member committee on prescription drugs FMS (Dutch Federation of Medical Specialists)
2013- Member Lunteren symposium committee NVVI (Dutch Society for Immunology)
2012- Member quality committee NVR (Dutch Association of Rheumatologists)
2010-2011 Member scientific committee European Workshop for Rheumatology Research 2011
2010-2014 Member working group EMerging EULAR NETwork (EMEUNET) and Country Liaison for the Netherlands
2010-2012 Member of board NVR (Dutch Association of Rheumatologists)
2008-2014 Junior associate editor Netherlands Journal of Medicine
2007- Reviewer Arthritis & Rheumatology, Annals of Rheumatic Diseases, Arthritis Research & Therapy.

2008-2011 Fellowship Rheumatology, Academic Medical Center/University of Amsterdam

2005-2008 Residency Internal Medicine, Tergooiziekenhuizen, Hilversum

2002-2005 PhD program, Div. of Clinical Immunology and Rheumatology, AMC/University of Amsterdam. Thesis: “Targeting NF-kappaB to modulate immune responses in arthritis”.Promotor: Prof. dr. P.P. Tak. Date of PhD: 12 april 2006.

2001-2002 Research Fellowship, Dept. of Rheumatology, Hammersmith Hospital/Imperial College School of Medicine, London, UK. Project: “Phagocytosis of apoptotic cells by macrophages from patients with systemic lupus erythematosus or rheumatoid arthritis”. Supervisors: Prof. dr. M.J. Walport and Prof. dr. M. Botto.

1998-1999 Research Fellowship, Dept. of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, USA. Project: “C1q and C4b bind to independent sites on CR1 and mediate erythrocyte adhesion”. Supervisors: Prof. dr. A. Nicholson-Weller and Dr. L.B. Klickstein.

1998 Student research project Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Project: “Binding of C1q to apoptotic rat mesangial cells in vitro”. Supervisors: Prof. dr. M.R. Daha and Dr. A. Roos.

Grants and Awards:

2016 Eureka course on Translational Medicine
2015 ACR/EULAR exchange program Stanford University
2014 Entrepreneurs in Clinical Academia (course on valorization of research) at INSEAD
2012- AAAS/Science Program for Excellence in Science
2011 Clinical Fellowship NWO (Netherlands Organisation for Scientific Research)
2009 Goslings award NVR (Dutch Association of Rheumatologists)
2008 Veni Grant NWO (Netherlands Organisation for Scientific Research)
2007 AMC Thesis Award 2006
2003 European League Against Rheumatism (EULAR) Young Investigator Award
1999 Leiden University Medical Center Award for best student research project
 

Research programmes

MD PhD S.W. Tas (The role of NF-κB signaling in the molecular regulation of inflammation)

Postdocs
PhD L.F.A. Huitema
PhD P. Kucharzewska
PhD J.P. van Hamburg

Prof. PhD P.P. Tak (The pathogenesis of rheumatic disease and development of innovative therapies)

Current research funding
  • AMC
  • AbbVie B.V.
  • Arthrogen BV
  • Bristol-Myers Squibb B.V. (0059)
  • Celgene International Il Sаrl
  • Crediteurenadm. VUmc, p/a Profource Service Center
  • GSK Service Unlimited (CERPS UK, JDE & UK GMS)
  • Genzyme Europe BV
  • Pfizer B.V. (4726)
  • Shire Netherlands B.V.
  • Stichting AMC Foundation (Vrijgesteld)
  • Stichting ReumaNederland