foto

PhD G.B. Afink

Position
Research Associate
Main activities
Research
Specialisation
Molecular Biology
Focus of research

About 25% of all pregnancies are complicated by gestational disease, of which severe hypertension (i.e. early preeclampsia and HELLP syndrome) and preterm labour are the leading cause of pregnancy-related maternal morbidity and mortality and poor neonatal outcome. Although there is consensus that the causal organ for these gestational diseases is the placenta the underlying multifactorial molecular causes and early and reliable clinical biomarkers that explain and predict development of obstetrical disease during the course of pregnancy are not available.

Key publications
  • Ho Lena, van Dijk Marie, Chye Sam Tan Jian, Messerschmidt Daniel M., Chng Serene C., Ong Sheena, Yi Ling Ka, Boussata Souad, Goh Grace Hui-Yi, Afink Gijs B., Lim Chin Yan, Dunn N. Ray, Solter Davor, Knowles Barbara B., Reversade Bruno ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice Science 2017;357 (6352):707-713 [PubMed]
  • van Uitert Miranda, Moerland Perry D., Enquobahrie Daniel A., Laivuori Hannele, van der Post Joris A. M., Ris-Stalpers Carrie, Afink Gijs B. Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia PLoS ONE 2015;10 (7):e0132468 [PubMed]
  • Jebbink Jiska, Veenboer Geertruda, Boussata Souad, Keijser Remco, Kremer Andreas E., Elferink Ronald Oude, van der Post Joris, Afink Gijs, Ris-Stalpers Carrie Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015;1852 (1):131-136 [PubMed]
  • Kleinrouweler C. Emily, van Uitert Miranda, Moerland Perry D., Ris-Stalpers Carrie, van der Post Joris A. M., Afink Gijs B. Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis PLoS ONE 2013;8 (7):e68991 [PubMed]
  • Jebbink Jiska, Keijser Remco, Veenboer Geertruda, van der Post Joris, Ris-Stalpers Carrie, Afink Gijs Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth Hypertension 2011;58 (1):70-U129 [PubMed]
All Publications
Research programmes

Prof. PhD S. Repping (Reproduction & Development -- Human Reproduction)

 Our research focusses on clinical and basic aspects of Human Reproductive Biology.

 See also: De Jonge Akademie (includes videos) and Nieuw leven in het lab : Geassisteerde voortplanting (video)

Faculty
PhD E.A.F. AF Dancet
PhD G.B. Afink
PhD I.M. Custers
Prof. D.G. de Rooij
Prof. MD PhD M. Goddijn
PhD G. Hamer
PhD S. Mastenbroek
MD PhD M.H. Mochtar
MD PhD F. Mol
Prof. PhD B.D. Reversade
PhD C. Ris-Stalpers
Prof. PhD F. van der Veen
PhD M. van Dijk
Prof. PhD A.M.M. van Pelt
PhD M. van Wely

Others
T.S. de Vries
BSc C.M. de Winter-Korver
BEng BSc R. Keijser
BSc S.K.M. van Daalen
BEng G.J.M. Veenboer

PhD G.B. Afink (Promoties)

Prof. MD PhD J.A.M. van der Post (Reproductive Health, placental disease and maternal and fetal diseases)

 Placental dysfunction is the cause of gestational diseases like preeclampsia, gestational hypertension and preterm birth. Inappropriate Maternal-Fetal interaction leads to uterine and maternal systemic dysfunction and consequently maternal and fetal disease. Most maternal disease is reversible by delivery, though gestational hypertension is predictive for later onset of cardio vascular disease. Fetal disease like growth retardation and preterm birth may have life long consequences.  

The research programme focusses on describing pathways of the placental-specific differentially up-regulated genes in the clinical entities of HELLP/preeclampsia and preterm birth and tries to find 

a. disease specific placental bio-markers

c. therapeutics 

Faculty
PhD G.B. Afink
MD PhD I.M. de Graaf
MD PhD J.W. Ganzevoort
MD PhD P.J. Hajenius
MD PhD M. Kok
PhD M.A. Oudijk
MD PhD R.C. Painter
Prof. MD PhD E. Pajkrt
PhD C. Ris-Stalpers
Prof. PhD T.J. Roseboom
E. van Leeuwen

Others
BEng BSc R. Keijser
BEng G.J.M. Veenboer