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PhD G.B. Afink

Position
Research Associate
Main activities
Research
Specialisation
Molecular Biology
Focus of research

About 25% of all pregnancies are complicated by gestational disease, of which severe hypertension (i.e. early preeclampsia and HELLP syndrome) and preterm labour are the leading cause of pregnancy-related maternal morbidity and mortality and poor neonatal outcome. Although there is consensus that the causal organ for these gestational diseases is the placenta the underlying multifactorial molecular causes and early and reliable clinical biomarkers that explain and predict development of obstetrical disease during the course of pregnancy are not available.

Key publications
  • Ho Lena, van Dijk Marie, Chye Sam Tan Jian, Messerschmidt Daniel M., Chng Serene C., Ong Sheena, Yi Ling Ka, Boussata Souad, Goh Grace Hui-Yi, Afink Gijs B., Lim Chin Yan, Dunn N. Ray, Solter Davor, Knowles Barbara B., Reversade Bruno ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice Science 2017;357 (6352):707-713 [PubMed]
  • van Uitert Miranda, Moerland Perry D., Enquobahrie Daniel A., Laivuori Hannele, van der Post Joris A. M., Ris-Stalpers Carrie, Afink Gijs B. Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia PLoS ONE 2015;10 (7):e0132468 [PubMed]
  • Jebbink Jiska, Veenboer Geertruda, Boussata Souad, Keijser Remco, Kremer Andreas E., Elferink Ronald Oude, van der Post Joris, Afink Gijs, Ris-Stalpers Carrie Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015;1852 (1):131-136 [PubMed]
  • Kleinrouweler C. Emily, van Uitert Miranda, Moerland Perry D., Ris-Stalpers Carrie, van der Post Joris A. M., Afink Gijs B. Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis PLoS ONE 2013;8 (7):e68991 [PubMed]
  • Jebbink Jiska, Keijser Remco, Veenboer Geertruda, van der Post Joris, Ris-Stalpers Carrie, Afink Gijs Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth Hypertension 2011;58 (1):70-U129 [PubMed]
All Publications
Research programmes

Prof. PhD S. Repping (Reproduction & Development -- Human Reproduction)

PhD G.B. Afink (Promoties)

Prof. MD PhD J.A.M. van der Post (Reproductive Health, placental disease and maternal and fetal diseases)