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Prof. PhD A.K. Groen

Positions
Full Professor, Research Associate
Main activities
Education, Research
Specialisation
Systems Medicine
Focus of research

An integrated approach to study cardiometabolism

Key publications
  • van der Velde Astrid E., Vrins Carlos L. J., van den Oever Karin, Kunne Cindy, Elferink Ronald P. J. Oude, Kljipers Folkert, Groen Albert K. Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice Gastroenterology 2007;133 (3):967-975 [PubMed]
  • Kuipers Folkert, Bloks Vincent W., Groen Albert K. Beyond intestinal soap-bile acids in metabolic control Nature reviews. Endocrinology 2014;10 (8):488-498 [PubMed]
  • Out Carolien, Hageman Jurre, Bloks Vincent W., Gerrits Han, Sollewijn Gelpke Maarten D., Bos Trijnie, Havinga Rick, Smit Martin J., Kuipers Folkert, Groen Albert K. Liver Receptor Homolog-1 Is Critical for Adequate Up-regulation of Cyp7a1 Gene Transcription and Bile Salt Synthesis During Bile Salt Sequestration Hepatology (Baltimore, Md.) 2011;53 (6):2075-2085 [PubMed]
  • Jakulj Lily, van Dijk Theo H., de Boer Jan Freark, Kootte Ruud S., Schonewille Marleen, Paalvast Yared, Boer Theo, Bloks Vincent W., Boverhof Renze, Nieuwdorp Max, Beuers Ulrich H. W., Stroes Erik S. G., Groen Albert K. Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion Cell metabolism 2016;24 (6):783-794 [PubMed]
  • de Boer Jan Freark, Schonewille Marleen, Boesjes Marije, Wolters Henk, Bloks Vincent W., Bos Trijnie, van Dijk Theo H., Jurdzinski Angelika, Boverhof Renze, Wolters Justina C., Kuivenhoven Jan A., van Deursen Jan M., Oude Elferink Ronald P. J., Moschetta Antonio, Kremoser Claus, Verkade Henkjan J., Kuipers Folkert, Groen Albert K. Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice Gastroenterology 2017;152 (5):1126-1138.e6 [PubMed]
All Publications
Research programmes

Prof. PhD A.K. Groen (A systems biology approach to unravel the etiology of the Metabolic Syndrome)

Metabolic Syndrome  is defined as the clustering of abdominal obesity, elevated blood pressure, impaired glucose tolerance, high triglycerides  and low HDL-cholesterol and is widely used as simple clinical definition of overweight individuals at increased morbidity risk. The complexity of the interrelations between the different symptoms in Metabolic Syndrome has led to the need for the application of systems biology approaches to obtain a deep understanding of the mechanisms underlying the comorbidities.  To gather mechanistic insight in the etiology and interdependence of the different components of the Metabolic Syndrome we are developing a multiscale systems biology approach  using both dynamic and genomewide metabolic modelling approaches. We aim to obtain a  comprehensive genomic and metabolic map of healthy humans and  metabolic syndrome patients including their microbiome. This will generate detailed insight in the metabolic network dysregulation in Metabolic Syndrome patients and will suggest novel therapeutic strategies to rebalance the metabolic networks.

 

 

PhD Students
T. Paalvast
S.A.J. van der AA
M. van der Stee
X. Zhang

Prof. MD PhD M. Nieuwdorp (Gutmicrobiota as novel diagnostic and therapeutic targets in cardiometabolism)

Our group focuses on the role of intestinal microbiota in chronic inflammation and human cardiometabolism in a translational fashion. We aim to find novel pathophysiological pathways driving cardiovascular disease, dyslipidemia and diabetes mellitus studying the role of baceria in adipose tissue, liver (NASH) and macrovascular inflammation. In line, we will try to identify novel therapeutic targets via identifying bacterial ligands or developing novel probiotic bacterial strains and vaccination leads to treat these diseases.

Faculty
MEng PhD G.M. Dallinga-Thie
Prof. PhD A.K. Groen
PhD J.H.M. Levels
PhD E. Levin
Prof. MD PhD E.S.G. Stroes
Prof. PhD N.A.W. van Riel

Postdocs
PhD M. Davids
PhD H.J. Herrema
MEng PhD S.K. Imangaliyev
PhD A. Prodan

PhD Students
K. Fluitman
MSc T. Scheithauer
MD M.J.B. van Baar
MD L. van Ruiten

Others
BSc J.C. Borger
MEng S.R. Havik
BEng J.P. Jansen
R. Schmitz
BEng M. Versloot
BEng M. Winkelmeijer
BSc D. Zwirs

Current research funding
  • AMC
  • AMC (Vrijgesteld)