Prof. PhD R.H.L. Houtkooper

Full Professor
Main activities
Mitochondrial metabolism
Focus of research
  • Mitochondria in health and disease
  • Metabolic aging
Key publications
  • Houtkooper Riekelt H., Mouchiroud Laurent, Ryu Dongryeol, Moullan Norman, Katsyuba Elena, Knott Graham, Williams Robert W., Auwerx Johan Mitonuclear protein imbalance as a conserved longevity mechanism Nature 2013;497 (7450):451-+ [PubMed]
  • Houtkooper Riekelt H., Pirinen Eija, Auwerx Johan Sirtuins as regulators of metabolism and healthspan Nature reviews. Molecular cell biology 2012;13 (4):225-238 [PubMed]
  • Mouchiroud Laurent, Houtkooper Riekelt H., Moullan Norman, Katsyuba Elena, Ryu Dongryeol, Cantó Carles, Mottis Adrienne, Jo Young-Suk, Viswanathan Mohan, Schoonjans Kristina, Guarente Leonard, Auwerx Johan The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling Cell 2013;154 (2):430-441 [PubMed]
  • Moullan Norman, Mouchiroud Laurent, Wang Xu, Ryu Dongryeol, Williams Evan G., Mottis Adrienne, Jovaisaite Virginija, Frochaux Michael V., Quiros Pedro M., Deplancke Bart, Houtkooper Riekelt H., Auwerx Johan Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research Cell reports 2015;10 (10):1681-1691 [PubMed]
  • Andreux Pénélope A., Houtkooper Riekelt H., Auwerx Johan Pharmacological approaches to restore mitochondrial function Nature reviews. Drug discovery 2013;12 (6):465-483 [PubMed]
All Publications
Research programmes

Prof. PhD R.H.L. Houtkooper (Translational metabolism)

PhD A.W. MacInnes
PhD R.L. Smith
MSc PhD M. van Weeghel
PhD R.C.I. Wust

BEng S.W. Denis
BEng L. IJlst
MSc R.S. Kamble
PhD M. Lezzerini
BEng A.M. Van Adrichem

Prof. PhD R.J.A. Wanders (Biochemistry & Enzymology of Metabolic Disorders)

Current research funding
  • AMC
  • AMC (Vrijgesteld)
  • Barth Syndrome Foundation
  • Diamond Blackfan Anaemia (DBA) Charity
  • Europese Unie
  • Federation of European Biochemical Societies (FEBS)
  • Nederlandse Hartstichting
  • ZonMw