Prof. PhD R.J.A. Wanders

Full Professor, Research Associate
Main activities
Patient care, Research, Other
Biochemistry, Enzymology.
Focus of research

Peroxisomes in health and disease.

Physiological role of peroxisomes in human health and disease with special emphasis on the enzymology and transport properties of peroxisomes.

Key publications
  • Houten Sander M., Violante Sara, Ventura Fatima V., Wanders Ronald J. A. The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders Annual review of physiology 2016;78:23-44 [PubMed]
  • Vaz Frédéric M., Paulusma Coen C., Huidekoper Hidde, de Ru Minke, Lim Cynthia, Koster Janet, Ho-Mok Kam, Bootsma Albert H., Groen Albert K., Schaap Frank G., Oude Elferink Ronald P. J., Waterham Hans R., Wanders Ronald J. A. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype Hepatology (Baltimore, Md.) 2015;61 (1):260-267 [PubMed]
  • Bennett Michael J., Rinaldo Piero, Wilcken Bridget, Pass Kenneth A., Watson Michael S., Wanders Ronald J. A. Newborn screening for metabolic disorders: how are we doing, and where are we going? Clinical chemistry 2012;58 (2):324-331 [PubMed]
  • Wanders Ronald J. A., Komen Jasper, Ferdinandusse Sacha Phytanic acid metabolism in health and disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2011;1811 (9):498-507 [PubMed]
  • van Roermund Carlo W. T., Visser Wouter F., Ijlst Lodewijk, Waterham Hans R., Wanders Ronald J. A. Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2011;1811 (3):148-152 [PubMed]
All Publications
Curriculum Vitae

Ronald (R.J.A.) Wanders has studied Chemistry at the University of Amsterdam with a subspecialization in Biochemistry and subsequently did his PhD at the E.C. Slater Institute for Biochemical Research, University of Amsterdam (1977-1982) under the leadership of Prof. Dr. J.M. Tager. In 1983 Wanders joined the Laboratory Genetic Metabolic Diseases at the Academic Medical Center (AMC) of the University of Amsterdam (UvA) as postdoc with the objective to: (1.) perform research on Zellweger syndrome and other peroxisomal disorders, and (2.) set up an Enzymology Laboratory, capable of doing selective enzyme assays in patients suspected to suffer from certain inborn errors of metabolism (IEMs) including peroxisomal diseases, fatty acid oxidation disorders, amino oxidation defects, among others. He is full professor in Clinical Enzymology of IEMs since 1996, and is Head of the Laboratory Genetic Metabolic Diseases since 2003. Wanders has been promotor of 34 completed PhD thesis works, and copromotor of ... PhD thesis works and has published more than 936 papers in peer-reviewed journals. Wanders is member of several Editorial Boards of scientific journals (Human Mutation (2006-2011), Biochimica Biophysica Acta, Molecular Basis of Diseases, Journal of Inherited Metabolic Disease, Molecular Genetics and Metabolism, Journal of Biological Chemistry, World Journal of Biological Chemistry), member of different medical Advisory Boards (Prinses Beatrix Fonds (PBF), European Leukodystrophy Association (ELA), Barth Syndrome Foundation (BSF), and member of different national and international Selection Committees, including NWO-VICI (2007-2011). Wanders has received several awards including the IFCC 2011 SDistinguished Award for Laboratory Medicine and Patient Care.


'71-76: M.SC Master of Sciences Chemistry with specialization in Biochemistry, University of Amsterdam.

'77-'82: PhD-student at the Department of Biochemistry, E.C. Slater Institute for Biomedical Research. Title Thesis: 'Quantitative studies on the control of flux'. (PhD Professor/Promotor: Prof. J.M. Tager).

'83-'88: Post-doc. fellow at the Laboratory of Genetic Metabolic Diseases, Departments of Pediatrics and Clinical Chemistry, Academic Medical Center, University of Amsterdam.

'88-present: Staff member, Department of Pediatrics, Academic Medical Center, University of Amsterdam.

'88-'96: Associate Professor and Head of the section Enzymology of Inherited Metabolic Diseases, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam.

'96-present: Professor of Clinical Enzymology & Inherited Metabolic Diseases, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam.

'03-present: Head of the laboratory of Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam.

Research programmes

Prof. PhD R.J.A. Wanders (Biochemistry & Enzymology of Metabolic Disorders)

Peroxisomes were long thought to play only a minimal role in human physiology until the early 1980s when studies in a rare lethal autosomal recessive disorder called Zellweger syndrome revealed that peroxisomes are in fact indispensible organelles playing a key role in human physiology. Indeed, peroxisomes are now known to catalyze multiple metabolic functions including: (1.) the beta-oxidation of certain fatty acids notably very long-chain fatty acids; (2.) the synthesis of etherphospholipids (plasmalogens); (3.) the alpha-oxidation of 3-methyl branched chain fatty acids including phytanic acid, and (4.) the detoxification of glyoxylate. Subsequent to the discovery of Zellweger syndrome as the prototype peroxisomal disorders many additional peroxisomal diseases have been identified. .......

PhD S. Ferdinandusse
Prof. PhD R.H.L. Houtkooper
PhD S. Kemp
PhD W. Kulik
PhD A.B.P. van Kuilenburg
PhD C.W.T. van Roermund
PhD F.M. Vaz
Prof. PhD H.R. Waterham

MSc PhD M. van Weeghel

BEng S.W. Denis
BEng L. IJlst
BSc H. te Brinke

Prof. PhD H.R. Waterham (Functional Genetics of Metabolic Diseases)

PhD S. Ferdinandusse (No title specified)

Current research funding
  • AMC (Vrijgesteld)
  • Medday Pharmaceuticals SA
  • ZonMw