Research line
When the first MRI scanners were introduced to the Netherlands in the early 80s, it was thought that 5 MRI scanners would serve the entire Dutch population. Presently more than 200 MRI scanners are installed and around 1 million exams are carried out each year. Several challenges and new developments still await us on the horizon. Higher field strengths will facilitate unprecedented spatial resolutions offering a unique view of anatomy and physiology of diseases. Novel acquisition and reconstruction methods will decrease the scan-time enormously, diminishing the burden of undergoing MRI for patients. Quantitative approaches are gaining popularity for acquisition and post-processing, in an effort to bridge the gap between the measured MRI signals and the (‘real’) underlying processes in the body. Interestingly, technical advances in MRI are primarily driven by the needs of medical professionals and patients. The ultimate challenge for MRI scientists is to make their new developments available to the clinic so that medical professionals and patients can benefit from state-of-the-art technology and healthcare.
My general research goal is to develop new clinical MRI methods. This entails the design of new MRI methods for clinical use, their technical and clinical validation and ultimately advising on their clinical utilization. Over the years several MRI applications has been developed in the field of neurovascular, muscular and oncologic imaging in close collaboration with clinical partners inside and outside the Amsterdam UMC. Focus areas of current research comprise scan acceleration using compressed sensing and AI and quantitative high resolution imaging.
Research highlights
- Advanced imaging of the carotid vessel wall
- 4D flow MRI for intracranial vasculature and aneurysms at 7T
- Functional imaging of the heart
- Quantitative MRI: Pathological validation and prognostic potential
- Perfusion imaging: Dynamic contrast enhanced magnetic resonance imaging using GRASP and machine learning
- Non-invasive perfusion and diffusion imaging: intravoxel incoherent motion difussion-weighted magnetic resonance imaging
- Quantitative Imaging of Skeletal Muscle Micro Structure and Damage
- Functional Magnetic Resonance Spectroscopy in the brain
- Functional brain imaging: task-based application and interventional studies
Research team
Faculty
Prof. Aart Nederveen, PhD (PI)
Paul Groot, PDEng
Sofieke de Jonge, PhD
Assistant Professors
Pim van Ooij, PhD
Ot Bakermans, PhD
Anouk Schrantee, PhD
Oliver Gurney-Champion, PhD
Post-docs
Melissa Hooijmans, PhD
Jurgen Runge, MD PhD
PhD students
Lukas Gottwald
Jithsa Monte, MD
Luuk Voskuilen
Carmen Blanken
Koen Baas
Liza Afzali-Hashemi
Laura Secondulfo
Marian Troelstra
Bobby Runderkamp
Susanne Rauh
Anne-Sophie van Schelt
Nienke Wassenaar
Support staff
Anita Robben-Auperle
Sandra van den Berg
Raschel Snoeks
Daphne Boucherie
Alumni
Sanna Gevers
Johan van der Meer
Andre Sprengers
Henk-Jan Mutsaerts
Martijn Froeling
Dennis Heijtel
Lena Vaclavu
Kerry Zhang
Wouter Potters
Jules Nelissen
Jos Oudeman
Jasper Schoormans
Eva Peper
Valentina Mazzoli
Matthan Caan
Bram Coolen
Joena Blok
Key publications
- van Werven, Jochem R; Marsman, Hendrik A; Nederveen, Aart J; Smits, Nico J; ten Kate, Fiebo J; van Gulik, Thomas M; Stoker, Jaap; Assessment of hepatic steatosis in patients undergoing liver resection: comparison of US, CT, T1-weighted dual-echo MR imaging, and point-resolved 1H MR spectroscopy, Radiology, 256, 1, 159-168, 2010
- Duivenvoorden, R; De Groot, E; Elsen, BM; Laméris, JS; Van Der Geest, RJ; Stroes, ES; Kastelein, JJP; Nederveen, AJ; In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging, Circulation: Cardiovascular Imaging, 2, 3, 235-242, 2009
- Figee, Martijn; Luigjes, Judy; Smolders, Ruud; Valencia-Alfonso, Carlos-Eduardo; Van Wingen, Guido; De Kwaasteniet, Bart; Mantione, Mariska; Ooms, Pieter; De Koning, Pelle; Vulink, Nienke; Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder, Nature neuroscience, 16, 4, 386, 2013
- Froeling, Martijn; Nederveen, Aart J; Heijtel, Dennis FR; Lataster, Arno; Bos, Clemens; Nicolay, Klaas; Maas, Mario; Drost, Maarten R; Strijkers, Gustav J; Diffusion‐tensor MRI reveals the complex muscle architecture of the human forearm, Journal of Magnetic Resonance Imaging, 36, 1, 237-248, 2012
- Zhang, Qinwei; Coolen, Bram F; Versluis, Maarten J; Strijkers, Gustav J; Nederveen, Aart J; Diffusion‐prepared stimulated‐echo turbo spin echo (DPsti‐TSE): an eddy current‐insensitive sequence for three‐dimensional high‐resolution and undistorted diffusion‐weighted imaging, NMR in Biomedicine, 30, 7, 2017
- Bakermans, Adrianus J; Wessel, Chang Ho; Zheng, Kang H; Groot, Paul FC; Stroes, Erik SG; Nederveen, Aart J; Dynamic magnetic resonance measurements of calf muscle oxygenation and energy metabolism in peripheral artery disease, Journal of Magnetic Resonance Imaging, 51, 1, 98-107, 2020
- Gottwald, Lukas M; Peper, Eva S; Zhang, Qinwei; Coolen, Bram F; Strijkers, Gustav J; Nederveen, Aart J; van Ooij, Pim; Pseudo‐spiral sampling and compressed sensing reconstruction provides flexibility of temporal resolution in accelerated aortic 4D flow MRI: A comparison with k‐t principal component analysis, NMR in Biomedicine, 33, 4, 2020
- Hooijmans, Melissa T; Monte, Jithsa RC; Froeling, Martijn; van den Berg‐Faay, Sandra; Aengevaeren, Vincent L; Hemke, Robert; Smithuis, Frank F; Eijsvogels, Thijs MH; Bakermans, Adrianus J; Maas, Mario; Quantitative MRI reveals microstructural changes in the upper leg muscles after running a marathon, Journal of Magnetic Resonance Imaging, 2020