B.P. Scicluna BA MSc PhD publications

2021

• Otto Natasja A., Butler Joe M., Ramirez-Moral Ivan, van Weeghel Michel, van Heijst Jeroen W. J., Scicluna Brendon P., Houtkooper Riekelt H., de Vos Alex F., van der Poll Tom Adherence affects monocyte innate immune function and metabolic reprogramming after lipopolysaccharide stimulation in vitro Journal of immunology (Baltimore, Md. 2021;206 (4):827-838 [PubMed]
• Qin Wanhai, Brands Xanthe, van't Veer Cornelis, de Vos Alex F., Scicluna Brendon P., van der Poll Tom Bronchial Epithelial Tet2 Maintains Epithelial Integrity during Acute Pseudomonas aeruginosa Pneumonia Infection and immunity 2021;89 (1) [PubMed]

2020

• Brands Xanthe, Haak Bastiaan W., Klarenbeek Augustijn M., Otto Natasja A., Faber Daniël R., Lutter René, Scicluna Brendon P., Wiersinga W. Joost, van der Poll Tom Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia Frontiers in immunology 2020;11 [PubMed]
• Brands Xanthe, Haak Bastiaan W., Klarenbeek Augustijn M., Otto Natasja A., Faber Daniël R., Lutter René, Scicluna Brendon P., Wiersinga W. Joost, van der Poll Tom Corrigendum: Concurrent Immune Suppression and Hyperinflammation in Patients With Community-Acquired Pneumonia (Front. Immunol, (2020), 11, (796), 10.3389/fimmu.2020.00796) Frontiers in immunology 2020;11 [PubMed]
• Bongaarts Anika, de Jong Jody M., Broekaart Diede W. M., van Scheppingen Jackelien, Anink Jasper J., Mijnsbergen Caroline, Jansen Floor E., Spliet Wim G. M., den Dunnen Wilfred F. A., Gruber Victoria E., Scholl Theresa, Hainfellner Johannes A., Feucht Martha, Borkowska Julita, Kotulska Katarzyna, Jozwiak Sergiusz, Grajkowska Wieslawa, Buccoliero Anna Maria, Caporalini Chiara, Giordano Flavio, Genitori Lorenzo, Scicluna Brendon P., Schouten-van Meeteren Antoinette Y. N., van Vliet Erwin A., Mühlebner Angelika, Mills James D., Aronica Eleonora Dysregulation of the MMP/TIMP Proteolytic System in Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex: Modulation of MMP by MicroRNA-320d In Vitro Journal of neuropathology and experimental neurology 2020;79 (7):777-790 [PubMed]
• Meijer Mariska T., Uhel Fabrice, Cremer Olaf L., Scicluna Brendon P., Schultz Marcus J., van der Poll Tom Elevated trefoil factor 3 plasma levels in critically ill patients with abdominal sepsis or non-infectious abdominal illness Cytokine 2020;133 [PubMed]
• Klein Klouwenberg Peter M. C., Spitoni Cristian, van der Poll Tom, Bonten Marc J., Cremer Olaf L., Schultz Marcus J., Horn Janneke, Scicluna Brendon, Wiewel Maryse A., Frencken Jos F., Groep Kirsten Van De, Koster-Brouwer Marlies E., Ong David S. Y., Verboom Diana, de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Schouten Laura R. A., Straat Marleen, Witteveen Esther, Wieske Luuk, Hoogendijk Arie J., Huson Mischa A., van Vught Lonneke A. Erratum: Predicting the clinical trajectory in critically ill patients with sepsis: A cohort study (Critical Care (2019) 2 (408) DOI: 10.1186/s13054-019-2687-z) Critical care (London, England) 2020;24 (1) [PubMed]
• Uhel Fabrice, Peters-Sengers Hessel, Falahi Fahimeh, Scicluna Brendon P., van Vught Lonneke A., Bonten Marc J., Cremer Olaf L., Schultz Marcus J., van der Poll Tom Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study Intensive care medicine 2020;46 (8):1576-1589 [PubMed]
• Ding Chao, Scicluna Brendon P., Stroo Ingrid, Yang Jack, Roelofs Joris J. TH, de Boer Onno J., de Vos Alex F., Nürnberg Peter, Revenko Alexey S., Crosby Jeff, van't Veer Cornelis, van der Poll Tom Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice Journal of pathology 2020;250 (1):95-106 [PubMed]
• Khan Hina N., Brands Xanthe, Aufiero Simona, Hoogendijk Arie J., Klarenbeek Augustijn M., van Engelen Tjitske S. R., Haak Bastiaan W., van Vught Lonneke A., Horn Janneke, Schultz Marcus J., Zwinderman Aeilko H., van der Poll Tom, Scicluna Brendon P. The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis Critical care (London, England) 2020;24 (1) [PubMed]
• Scicluna Brendon P, Uhel Fabrice, van Vught Lonneke A, Wiewel Maryse A, Hoogendijk Arie J, Baessman Ingelore, Franitza Marek, Nürnberg Peter, Horn Janneke, Cremer Olaf L, Bonten Marc J, Schultz Marcus J, van der Poll Tom The leukocyte non-coding RNA landscape in critically ill patients with sepsis eLife 2020;9:1-23 [PubMed]
• Yang Jack, Scicluna Brendon P, van Engelen Tjitske S R, Bonta Peter I, Majoor Christof J, van 't Veer Cornelis, de Vos Alex F, Bel Elisabeth H, van der Poll Tom Transcriptional changes in alveolar macrophages from adults with asthma after allergen challenge Allergy 2020 [PubMed]

2019

• Schouten Laura R., van Kaam Anton H., Kohse Franziska, Veltkamp Floor, Bos Lieuwe D., de Beer Friso M., van Hooijdonk Roosmarijn T., Horn Janneke, Straat Marleen, Witteveen Esther, Glas Gerie J., Wieske Luuk, van Vught Lonneke A., Wiewel Maryse A., Ingelse Sarah A., Cortjens Bart, van Woensel Job B., Bos Albert P., Walther Thomas, Schultz Marcus J., Wösten-van Asperen Roelie M., de Beer Friso M., Bos Lieuwe D., Glas Gerie J., Horn Janneke, Hoogendijk Arie J., van Hooijdonk Roosmarijn T., Huson Mischa A., van der Poll Tom, Scicluna Brendon, Schouten Laura R., Schultz Marcus J., Straat Marleen, van Vught Lonneke A., Wieske Luuk, Wiewel Maryse A., Witteveen Esther, Bonten Marc J., Cremer Olaf L., Frencken Jos F., van de Groep Kirsten, Klein Klouwenberg Peter M., Koster-Brouwer Maria E., Ong David S., Verboom Diana M. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study Annals of intensive care 2019;9 (1):55 [PubMed]
• Verboom Diana M., Koster-Brouwer Maria E., Ruurda Jelle P., van Hillegersberg Richard, van Berge Henegouwen Mark I., Gisbertz Suzanne S., Scicluna Brendon P., Bonten Marc J. M., Cremer Olaf L., Schultz Marcus A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery Journal of critical care 2019;54:83-87 [PubMed]
• Morales-Quinteros Luis, Schultz Marcus J., Bringué Josep, Calfee Carolyn S., Camprubí Marta, Cremer Olaf L., Horn Janneke, van der Poll Tom, Sinha Pratik, Artigas Antonio, Bos Lieuwe D., de Beer Friso M., Glas Gerie J., Hoogendijk Arie J., van Hooijdonk Roosmarijn T., Huson Mischa A., Scicluna Brendon, Schouten Laura R., Straat Marleen, van Vught Lonneke A., Wieske Luuk, Wiewel Maryse A., Witteveen Esther, Bonten Marc J., Frencken Jos F., van de Groep Kirsten, Klein Klouwenberg Peter M., Koster-Brouwer Maria E., Ong David S., Varkila Meri R., Verboom Diana M. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS Annals of intensive care 2019;9 (1) [PubMed]
• Leite Giuseppe Gianini Figuerêido, Scicluna Brendon P., van der Poll Tom, Salomão Reinaldo Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia NPJ systems biology and applications 2019;5:26 [PubMed]
• Perlee Desiree, de Vos Alex F., Scicluna Brendon P., Mancheño Pablo, de la Rosa Olga, Dalemans Wilfried, Nürnberg Peter, Lombardo Eleuterio, van der Poll Tom Human Adipose-Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae Stem cells translational medicine 2019;8 (8):785-796 [PubMed]
• Hoogendijk Arie J., van Vught Lonneke A., Wiewel Maryse A., Fuhler Gwenny M., Belkasim-Bohoudi Hakima, Horn Janneke, Schultz Marcus J., Scicluna Brendon P., Peppelenbosch Maikel P., van 't Veer Cornelis, de Vos Alex F., van der Poll Tom Kinase activity is impaired in neutrophils of sepsis patients Haematologica 2019;104 (6):e233-e235 [PubMed]
• Khan Hina N., Perlee Desiree, Schoenmaker Lieke, van der Meer Anne-Jan, Franitza Marek, Toliat Mohammad Reza, Nürnberg Peter, Zwinderman Aeilko H., van der Poll Tom, Scicluna Brendon P. Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia Journal of leukocyte biology 2019;106 (5):1153-1160 [PubMed]
• Uhel Fabrice, Scicluna Brendon P., van Vught Lonneke A., Cremer Olaf L., Bonten Marc J., Schultz Marcus J., van der Poll Tom Matrix metalloproteinase-8: A useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission? Critical care (London, England) 2019;23 (1) [PubMed]
• Frencken Jos F., van Baal Lottie, Kappen Teus H., Donker Dirk W., Horn Janneke, van der Poll Tom, van Klei Wilton A., Bonten Marc J. M., Cremer Olaf L., de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Schouten Laura R. A., Straat Marleen, Witteveen Esther, Wieske Luuk, van Vught Lonneke A., Wiewel Maryse, Hoogendijk Arie J., Huson Mischa A., Scicluna Brendon, Schultz Marcus J., Ong David S. Y., Klein Klouwenberg Peter M. C., van de Groep Kirsten, Verboom Diana, Koster-Brouwer Maria E. Myocardial injury in critically Ill patients with community-acquired pneumonia a cohort study Annals of the American Thoracic Society 2019;16 (5):606-612 [PubMed]
• Perlee Desirée, de Vos Alex F., Scicluna Brendon P., Maag Anja, Mancheño Pablo, de la Rosa Olga, Dalemans Wilfried, Florquin Sandrine, van't Veer Cornelis, Lombardo Eleuterio, van der Poll Tom Role of tissue factor in the procoagulant and antibacterial effects of human adipose-derived mesenchymal stem cells during pneumosepsis in mice STEM CELL RESEARCH & THERAPY 2019;10 (1) [PubMed]
• Bongaarts Anika, van Scheppingen Jackelien, Korotkov Anatoly, Mijnsbergen Caroline, Anink Jasper J., Jansen Floor E., Spliet Wim G. M., den Dunnen Wilfred F. A., Gruber Victoria E., Scholl Theresa, Samueli Sharon, Hainfellner Johannes A., Feucht Martha, Kotulska Katarzyna, Jozwiak Sergiusz, Grajkowska Wieslawa, Buccoliero Anna Maria, Caporalini Chiara, Giordano Flavio, Genitori Lorenzo, Coras Roland, Blümcke Ingmar, Krsek Pavel, Zamecnik Josef, Meijer Lisethe, Scicluna Brendon P., Schouten-van Meeteren Antoinette Y. N., Mühlebner Angelika, Mills James D., Aronica Eleonora The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas Brain 2019;143 (1):131-149 [PubMed]
• Domínguez-Andrés Jorge, Novakovic Boris, Li Yang, Scicluna Brendon P., Gresnigt Mark S., Arts Rob J.W., Oosting Marije, Moorlag Simone J.C.F.M., Groh Laszlo A., Zwaag Jelle, Koch Rebecca M., ter Horst Rob, Joosten Leo A.B., Wijmenga Cisca, Michelucci Alessandro, van der Poll Tom, Kox Matthijs, Pickkers Peter, Kumar Vinod, Stunnenberg Henk, Netea Mihai G. The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity Cell metabolism 2019;29 (1):211-220.e5 [PubMed]
• Scicluna Brendon P., Kenneth Baillie J. the search for efficacious new therapies in sepsis needs to embrace heterogeneity American journal of respiratory and critical care medicine 2019;199 (8):936-938 [PubMed]
• Bos Lieuwe D J, Scicluna Brendon P, Ong David S Y, Cremer Olaf, van der Poll Tom, Schultz Marcus J Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles American journal of respiratory and critical care medicine 2019;200 (1):42-50 [PubMed]

2018

• Scicluna Brendon P., Wiewel Maryse A., van Vught Lonneke A., Hoogendijk Arie J., Klarenbeek Augustijn M., Franitza Marek, Toliat Mohammad R., Nürnberg Peter, Horn Janneke, Bonten Marc J., Schultz Marcus J., Cremer Olaf L., van der Poll Tom A Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis Upon Intensive Care Unit Admission American journal of respiratory and critical care medicine 2018;197 (8):1070-1073 [PubMed]
• van der Poll Tom, van de Veerdonk Frank L., Scicluna Brendon P., Netea Mihai G. Are histones real pathogenic agents in sepsis? Nature reviews. Immunology 2018;18 (2):148 [PubMed]
• van Engelen Tjitske S. R., Wiersinga Willem Joost, Scicluna Brendon P., van der Poll Tom Biomarkers in Sepsis Critical care clinics 2018;34 (1):139-+ [PubMed]
• Wittebole Xavier, Scicluna Brendon P. Classification of patients with septic shock: Are we there yet? Journal of critical care 2018;47:320-321 [PubMed]
• Perlee Desiree, van Vught Lonneke A., Scicluna Brendon P., Maag Anja, Lutter René, Kemper Elles M., van ‘t Veer Cornelis, Punchard Marie A., González Jesús, Richard Marie Paule, Dalemans Wilfried, Lombardo Eleuterio, de Vos Alex F., van der Poll Tom Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single-Blind, Parallel Group, Placebo Controlled Trial Stem cells (Dayton, Ohio) 2018;36 (11):1778-1788 [PubMed]
• Boshuizen Margit, Binnekade Jan M., Nota Benjamin, van de Groep Kirsten, Cremer Olaf L., Tuinman Pieter R., Horn Janneke, Schultz Marcus J., van Bruggen Robin, Juffermans Nicole P., de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Schouten Laura R. A., Straat Marleen, Witteveen Esther, Wieske Luuk, Hoogendijk Arie J., Huson Mischa A., Scicluna Brendon P., van der Poll Tom, van Vught Lonneke A., Wiewel Maryse A., Bonten Marc J. M., Frencken Jos F., Klein Klouwenberg Peter M. C., Koster-Brouwer Maria E., Ong David S. Y., Verboom Diana M. Iron metabolism in critically ill patients developing anemia of inflammation: a case control study Annals of intensive care 2018;8 (1) [PubMed]
• Hsiao Cheng-Chih, Chu Tai-Ying, Wu Chia-Jung, van den Biggelaar Maartje, Pabst Caroline, Hébert Josée, Kuijpers Taco W., Scicluna Brendon P., I Kuan-Yu, Chen Tse-Ching, Liebscher Ines, Hamann J. rg, Lin Hsi-Hsien The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions Frontiers in immunology 2018;9:2830 [PubMed]
• Wiewel Maryse A., Scicluna Brendon P., van Vught Lonneke A., Hoogendijk Arie J., Zwinderman Aeilko H., Lutter René, Horn Janneke, Cremer Olaf L., Bonten Marc J., Schultz Marcus J., van der Poll Tom The host response in critically ill sepsis patients on statin therapy: a prospective observational study Annals of intensive care 2018;8 (1):9 [PubMed]
• Miller Russell R., Lopansri Bert K., Burke John P., Levy Mitchell, Opal Steven, Rothman Richard E., D'Alessio Franco R., Sidhaye Venkataramana K., Aggarwal Neil R., Balk Robert, Greenberg Jared A., Yoder Mark, Patel Gourang, Gilbert Emily, Afshar Majid, Parada Jorge P., Martin Greg S., Esper Annette M., Kempker Jordan A., Narasimhan Mangala, Tsegaye Adey, Hahn Stella, Mayo Paul, van der Poll Tom, Schultz Marcus J., Scicluna Brendon P., Klouwenberg Peter Klein, Rapisarda Antony, Seldon Therese A., McHugh Leo C., Yager Thomas D., Cermelli Silvia, Sampson Dayle, Rothwell Victoria, Newman Richard, Bhide Shruti, Fox Brian A., Kirk James T., Navalkar Krupa, Davis Roy F., Brandon Roslyn A., Brandon Richard B. Validation of a host response assay, SeptiCyte LAB, for discriminating sepsis from systemic inflammatory response syndrome in the ICU American journal of respiratory and critical care medicine 2018;198 (7):903-913 [PubMed]
• Koster-Brouwer Maria E., Verboom Diana M., Scicluna Brendon P., van de Groep Kirsten, Frencken Jos F., Janssen Davy, Schuurman Rob, Schultz Marcus J., van der Poll Tom, Bonten Marc J. M., Cremer Olaf L., de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., Hoogendijk Arie J., van Hooijdonk Roosmarijn T. M., Horn Janneke, Huson Mischa A., Klein Klouwenberg Peter M. C., Ong David S. Y., Schouten Laura R. A., Straat Marleen, van Vught Lonneke A., Wieske Luuk, Wiewel Maryse A., Witteveen Esther Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure Critical care medicine 2018;46 (3):368-374 [PubMed]

2017

• van Vught Lonneke A., Scicluna Brendon P., Wiewel Maryse A., Hoogendijk Arie J., Klein Klouwenberg Peter M. C., Ong David S. Y., Cremer Olaf L., Horn Janneke, Franitza Marek, Toliat Mohammad R., Nürnberg Peter, Bonten Marc M. J., Schultz Marcus J., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Frencken Jos F., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Huson Michaëla A. M., Schouten Laura R. A., Straat Marleen, Wieske Luuk, Witteveen Esther Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients Critical care medicine 2017;45 (11):1854-1862 [PubMed]
• Scicluna Brendon P., van Vught Lonneke A., Zwinderman Aeilko H., Wiewel Maryse A., Davenport Emma E., Burnham Katie L., Nürnberg Peter, Schultz Marcus J., Horn Janneke, Cremer Olaf L., Bonten Marc J., Hinds Charles J., Wong Hector R., Knight Julian C., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Frencken Jos F., Koster-Brouwer Maria E., van de Groep Kirsten, Verboom Diana M., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Hoogendijk Arie J., Huson Mischa A., Klouwenberg Peter M. Klein, Ong David S. Y., Schouten Laura R. A., Straat Marleen, Witteveen Esther, Wieske Luuk Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study lancet. Respiratory medicine 2017;5 (10):816-826 [PubMed]
• Mills James D., Iyer Anand M., van Scheppingen Jackelien, Bongaarts Anika, Anink Jasper J., Janssen Bart, Zimmer Till S., Spliet Wim G., van Rijen Peter C., Jansen Floor E., Feucht Martha, Hainfellner Johannes A., Krsek Pavel, Zamecnik Josef, Kotulska Katarzyna, Jozwiak Sergiusz, Jansen Anna, Lagae Lieven, Curatolo Paolo, Kwiatkowski David J., Pasterkamp R. Jeroen, Senthilkumar Ketharini, von Oerthel Lars, Hoekman Marco F., Gorter Jan A., Crino Peter B., Mühlebner Angelika, Scicluna Brendon P., Aronica Eleonora Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment Scientific reports 2017;7 (1):8089 [PubMed]
• Bos L. D., Schouten L. R., van Vught L. A., Wiewel M. A., Ong D. S. Y., Cremer O., Artigas A., Martin-Loeches I., Hoogendijk A. J., van der Poll T., Horn J., Juffermans N., Calfee C. S., Schultz M. J., Frencken Jos F., Bonten Marc, Klein Klouwenberg Peter M. C., van Hooijdonk Roosmarijn T. M., Huson Mischa A., Straat Marleen, Witteveen Esther, Glas Gerie J., Wieske Luuk, Scicluna Brendon P., Belkasim-Bohoudi H. Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis Thorax 2017;72 (10):876-883 [PubMed]
• Wiewel Maryse A., van Vught Lonneke A., Scicluna Brendon P., Hoogendijk Arie J., Frencken Jos F., Zwinderman Aeilko H., Horn Janneke, Cremer Olaf L., Bonten Marc J., Schultz Marcus J., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Huson Mischa A., Klein Klouwenberg Peter M. C., Ong David S. Y., Schouten Laura R. A., Straat Marleen, Witteveen Esther, Wieske Luuk Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis: A Prospective Observational Study Critical care medicine 2017;45 (3):454-463 [PubMed]
• Pisani Luigi, Roozeman Jan-Paul, Simonis Fabienne D., Giangregorio Antonio, van der Hoeven Sophia M., Schouten Laura R., Horn Janneke, Serpa Neto Ary, Festic Emir, Dondorp Arjen M., Grasso Salvatore, Bos Lieuwe D., Schultz Marcus J., van Hooijdonk Roosmarijn T. M., Huson Mischa A., Schouten Laura R. A., Straat Marleen, van Vught Lonneke A., Wiewel Maryse A., Witteveen Esther, Glas Gerie J., Wieske Luuk, Frencken Jos F., Bonten Marc, Klein Klouwenberg Peter M. C., Ong David, Scicluna Brendon P., Hoogendijk Arjan J., Belkasim-Bohoudi H., van der Poll Tom Risk stratification using SpO2/FiO2 and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS Annals of intensive care 2017;7 (1) [PubMed]
• Hoogendijk Arie J., Garcia-Laorden M. Isabel, van Vught Lonneke A., Wiewel Maryse A., Belkasim-Bohoudi Hakima, Duitman Janwillem, Horn Janneke, Schultz Marcus J., Scicluna Brendon P., van 't Veer Cornelis, de Vos Alex F., van der Poll Tom Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types Critical care medicine 2017;45 (5):e524-e531 [PubMed]
• Lankelma Jacqueline M., Birnie Emma, Weehuizen Tassili A. F., Scicluna Brendon P., Belzer Clara, Houtkooper Riekelt H., Roelofs Joris J. T. H., de Vos Alex F., van der Poll Tom, Budding Andries E., Wiersinga W. Joost The gut microbiota as a modulator of innate immunity during melioidosis PLoS neglected tropical diseases 2017;11 (4):e0005548 [PubMed]
• van Vught Lonneke A., Wiewel Maryse A., Hoogendijk Arie J., Frencken Jos F., Scicluna Brendon P., Klein Klouwenberg Peter M. C., Zwinderman Aeilko H., Lutter Rene, Horn Janneke, Schultz Marcus J., Bonten Marc M. J., Cremer Olaf L., van der Poll Tom The Host Response in Patients with Sepsis Developing Intensive Care Unit-acquired Secondary Infections American journal of respiratory and critical care medicine 2017;196 (4):458-470 [PubMed]
• van der Poll Tom, van de Veerdonk Frank L., Scicluna Brendon P., Netea Mihai G. The immunopathology of sepsis and potential therapeutic targets Nature reviews. Immunology 2017;17 (7):407-420 [PubMed]
• Scicluna Brendon P., van der Poll Tom Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers Critical care medicine 2017;45 (4):E457 [PubMed]

2016

• van Vught Lonneke A., Wiewel Maryse A., Klein Klouwenberg Peter M. C., Hoogendijk Arie J., Scicluna Brendon P., Ong David S. Y., Cremer Olaf L., Horn Janneke, Bonten Marc M. J., Schultz Marcus J., van der Poll Tom, de Beer FrisoM, Bos LieuweD J., Frencken JosF, Glas GerieJ, van Hooijdonk RoosmarijnT M., Huson MichaëlaA M., Schouten LauraR A., Straat Marleen, Witteveen Esther, Wieske Luuk Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response Critical care medicine 2016;44 (7):1338-1346 [PubMed]
• van Vught Lonneke A., Scicluna Brendon P., Hoogendijk Arie J., Wiewel Maryse A., Klein Klouwenberg Peter M. C., Cremer Olaf L., Horn Janneke, Nürnberg Peter, Bonten Marc M. J., Schultz Marcus J., van der Poll Tom Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients Critical care (London, England) 2016;20 (1):252 [PubMed]
• Cheng Shih-Chin, Scicluna Brendon P., Arts Rob J. W., Gresnigt Mark S., Lachmandas Ekta, Giamarellos-Bourboulis Evangelos J., Kox Matthijs, Manjeri Ganesh R., Wagenaars Jori A. L., Cremer Olaf L., Leentjens Jenneke, van der Meer Anne J., van de Veerdonk Frank L., Bonten Marc J., Schultz Marcus J., Willems Peter H. G. M., Pickkers Peter, Joosten Leo A. B., van der Poll Tom, Netea Mihai G. Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis Nature immunology 2016;17 (4):406-413 [PubMed]
• Wiewel Maryse A., de Stoppelaar Sacha F., van Vught Lonneke A., Frencken Jos F., Hoogendijk Arie J., Klein Klouwenberg Peter M. C., Horn Janneke, Bonten Marc J., Zwinderman Aeilko H., Cremer Olaf L., Schultz Marcus J., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Huson Mischa A., Ong David S. Y., Schouten Laura R. A., Scicluna Brendon P., Straat Marleen, Witteveen Esther, Wieske Luuk Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis Intensive care medicine 2016;42 (3):352-360 [PubMed]
• van Vught Lonneke A., Scicluna Brendon P., Wiewel Maryse A., Hoogendijk Arie J., Klein Klouwenberg Peter M. C., Franitza Marek, Toliat Mohammad R., Nürnberg Peter, Cremer Olaf L., Horn Janneke, Schultz Marcus J., Bonten Marc M. J., van der Poll Tom Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients American journal of respiratory and critical care medicine 2016;194 (11):1366-1374 [PubMed]
• Scicluna Brendon P., van Vught Lonneke A., van der Poll Tom, Klein Klouwenberg Peter M. C., Cremer Olaf L. FAIM3:PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired Pneumonia: Comparing Apples to Oranges? Reply American journal of respiratory and critical care medicine 2016;193 (1):102-103 [PubMed]
• Wiewel Maryse A., Huson Michaëla A., van Vught Lonneke A., Hoogendijk Arie J., Klein Klouwenberg Peter M. C., Horn Janneke, Lutter René, Cremer Olaf L., Schultz Marcus J., Bonten Marc J., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Frencken Jos F., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Ong David S. Y., Schouten Laura R. A., Scicluna Brendon P., Straat Marleen, Witteveen Esther, Wieske Luuk Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study Critical care (London, England) 2016;20 (1):322 [PubMed]
• van Vught Lonneke A., Klein Klouwenberg Peter M. C., Spitoni Cristian, Scicluna Brendon P., Wiewel Maryse A., Horn Janneke, Schultz Marcus J., Nürnberg Peter, Bonten Marc J. M., Cremer Olaf L., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Frencken Jos F., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Hoogendijk Arie J., Huson Mischa A., Ong David S. Y., Schouten Laura R. A., Straat Marleen, Witteveen Esther, Wieske Luuk Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis JAMA 2016;315 (14):1469-1479 [PubMed]
• Wiewel Maryse A., Harmon Matthew B., van Vught Lonneke A., Scicluna Brendon P., Hoogendijk Arie J., Horn Janneke, Zwinderman Aeilko H., Cremer Olaf L., Bonten Marc J., Schultz Marcus J., van der Poll Tom, Juffermans Nicole P., Wiersinga W. Joost Risk factors, host response and outcome of hypothermic sepsis Critical care (London, England) 2016;20 (1):328 [PubMed]
• van Vught Lonneke A. Sepsis in the intensive care unit: epidemiology, outcome and host response 2016. 367p. ISBN 9789462954625. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van der Poll T.; Co-supervisor: Scicluna B. P.)
• Schuijt Tim J., Lankelma Jacqueline M., Scicluna Brendon P., de Sousa E Melo Felipe, Roelofs Joris J. T. H., de Boer J. Daan, Hoogendijk Arjan J., de Beer Regina, de Vos Alex, Belzer Clara, de Vos Willem M., van der Poll Tom, Wiersinga W. Joost The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia Gut 2016;65 (4):575-583 [PubMed]
• Huson Michaëla A. M., Scicluna Brendon P., van Vught Lonneke A., Wiewel Maryse A., Hoogendijk Arie J., Cremer Olaf L., Bonten Marc J. M., Schultz Marcus J., Franitza Marek, Toliat Mohammad R., Nürnberg Peter, Grobusch Martin P., van der Poll Tom The Impact of HIV Co-Infection on the Genomic Response to Sepsis PLoS ONE 2016;11 (2):e0148955 [PubMed]
• Claushuis Theodora A. M., van Vught Lonneke A., Scicluna Brendon P., Wiewel Maryse A., Klein Klouwenberg Peter M. C., Hoogendijk Arie J., Ong David S. Y., Cremer Olaf L., Horn Janneke, Franitza Marek, Toliat Mohammad R., Nürnberg Peter, Zwinderman Aeilko H., Bonten Marc J., Schultz Marcus J., van der Poll Tom Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients Blood 2016;127 (24):3062-3072 [PubMed]

2015

• Scicluna Brendon P., Klein Klouwenberg Peter M. C., van Vught Lonneke A., Wiewel Maryse A., Ong David S. Y., Zwinderman Aeilko H., Franitza Marek, Toliat Mohammad R., Nürnberg Peter, Hoogendijk Arie J., Horn Janneke, Cremer Olaf L., Schultz Marcus J., Bonten Marc J., van der Poll Tom A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission American journal of respiratory and critical care medicine 2015;192 (7):826-835 [PubMed]
• McHugh Leo, Seldon Therese A., Brandon Roslyn A., Kirk James T., Rapisarda Antony, Sutherland Allison J., Presneill Jeffrey J., Venter Deon J., Lipman Jeffrey, Thomas Mervyn R., Klein Klouwenberg Peter M. C., van Vught Lonneke, Scicluna Brendon, Bonten Marc, Cremer Olaf L., Schultz Marcus J., van der Poll Tom, Yager Thomas D., Brandon Richard B. A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts PLoS medicine 2015;12 (12):e1001916 [PubMed]
• Scicluna Brendon P., Remme Carol Ann, Rivaud Mathilde, Wilde Arthur A. M., Bezzina Connie R., Verkerk Arie O. Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding International journal of cardiology 2015;201:49-52 [PubMed]
• Scicluna Brendon P., Klein Klouwenberg Peter M. C., van der Poll Tom Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data Reply American journal of respiratory and critical care medicine 2015;192 (10):1261-1262 [PubMed]
• Hoeksema Marten A., Scicluna Brendon P., Boshuizen Marieke C. S., van der Velden Saskia, Neele Annette E., van den Bossche Jan, Matlung Hanke L., van den Berg Timo K., Goossens Pieter, de Winther Menno P. J. IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment Journal of immunology (Baltimore, Md. 2015;194 (8):3909-3916 [PubMed]
• Scicluna Brendon P., van Lieshout Miriam H., Blok Dana C., Florquin Sandrine, van der Poll Tom Modular Transcriptional Networks of the Host Pulmonary Response during Early and Late Pneumococcal Pneumonia Molecular medicine (Cambridge, Mass.) 2015;21 (1):430-441 [PubMed]
• Hoogendijk Arie J., Wiewel Maryse A., van Vught Lonneke A., Scicluna Brendon P., Belkasim-Bohoudi Hakima, Horn Janneke, Zwinderman Aeilko H., Klein Klouwenberg Peter M. C., Cremer Olaf L., Bonten Marc J., Schultz Marcus J., van der Poll Tom, de Beer Friso M., Bos Lieuwe D. J., Frencken Jos F., Glas Gerie J., van Hooijdonk Roosmarijn T. M., Huson Mischa A., Ong David S. Y., Schouten Laura R. A., Straat Marleen, Witteveen Esther Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients Critical care (London, England) 2015;19 (1):412 [PubMed]
• van Vught Lonneke A., Wiewel Maryse A., Hoogendijk Arie J., Scicluna Brendon P., Belkasim-Bohoudi Hakima, Horn Janneke, Schultz Marcus J., van der Poll Tom Reduced Responsiveness of Blood Leukocytes to Lipopolysaccharide Does not Predict Nosocomial Infections in Critically Ill Patients Shock (Augusta, Ga.) 2015;44 (2):110-114 [PubMed]
• van der Meer Anne J., Scicluna Brendon P., Moerland Perry D., Lin Jiang, Jacobson Eric W., Vlasuk George P., van der Poll Tom The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans Critical care medicine 2015;43 (6):e199-e202 [PubMed]

2014

• Lodder Elisabeth M., Scicluna Brendon P., Beekman Leander, Arends Danny, Moerland Perry D., Tanck Michael W. T., Adriaens Michiel E., Bezzina Connie R. Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition Circulation. Cardiovascular genetics 2014;7 (6):790-798 [PubMed]
• van Lieshout Miriam H., Scicluna Brendon P., Florquin Sandrine, van der Poll Tom NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia American journal of respiratory cell and molecular biology 2014;50 (4):699-712 [PubMed]
• van Vught L. A., Endeman H., Meijvis S. C., Zwinderman A. H., Scicluna B. P., Biesma D. H., van der Poll T. The effect of age on the systemic inflammatory response in patients with community-acquired pneumonia Clinical microbiology and infection 2014;20 (11):1183-1188 [PubMed]

2013

• Scicluna Brendon P., van 't Veer Cornelis, Nieuwdorp Max, Felsmann Karen, Wlotzka Britta, Stroes Erik S. G., van der Poll Tom Role of tumor necrosis factor-α in the human systemic endotoxin-induced transcriptome PLoS ONE 2013;8 (11):e79051 [PubMed]

2012

• Lodder Elisabeth M., Scicluna Brendon P., Milano Annalisa, Sun Albert Y., Tang Hao, Remme Carol Ann, Moerland Perry D., Tanck Michael W. T., Pitt Geoffrey S., Marchuk Douglas A., Bezzina Connie R. Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction PLoS genetics 2012;8 (12):e1003113 [PubMed]
• Verkerk Arie O., Remme Carol Ann, Schumacher Cees A., Scicluna Brendon P., Wolswinkel Rianne, de Jonge Berend, Bezzina Connie R., Veldkamp Marieke W. Functional Na(V)1.8 Channels in Intracardiac Neurons The Link Between SCN10A and Cardiac Electrophysiology Circulation research 2012;111 (3):333-343 [PubMed]
• Scicluna Brendon P., van der Poll Tom Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling Critical care (London, England) 2012;16 (6):188 [PubMed]

2011

• Fabritz Larissa, Hoogendijk Mark G., Scicluna Brendon P., van Amersfoorth Shirley C. M., Fortmueller Lisa, Wolf Susanne, Laakmann Sandra, Kreienkamp Nina, Piccini Ilaria, Breithardt Günter, Noppinger Patricia Ruiz, Witt Henning, Ebnet Klaus, Wichter Thomas, Levkau Bodo, Franke Werner W., Pieperhoff Sebastian, de Bakker Jacques M. T., Coronel Ruben, Kirchhof Paulus Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice Journal of the American College of Cardiology 2011;57 (6):740-750 [PubMed]
• Scicluna Brendon P., Tanck Michael W. T., Remme Carol Ann, Beekman Leander, Coronel Ruben, Wilde Arthur A. M., Bezzina Connie R. Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse Journal of molecular and cellular cardiology 2011;50 (3):380-389 [PubMed]
• Scicluna Brendon System-based approach for the identification of novel genes influencing cardiac electrical traits 2011. 190p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Wilde A. A. M.; Co-supervisor: Bezzina C. R.)

2010

• Bezzina Connie R., Pazoki Raha, Bardai Abdennasser, Marsman Roos F., de Jong Jonas S. S. G., Blom Marieke T., Scicluna Brendon P., Jukema J. Wouter, Bindraban Navin R., Lichtner Peter, Pfeufer Arne, Bishopric Nanette H., Roden Dan M., Meitinger Thomas, Chugh Sumeet S., Myerburg Robert J., Jouven Xavier, Kääb Stefan, Dekker Lukas R. C., Tan Hanno L., Tanck Michael W. T., Wilde Arthur A. M. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction Nature genetics 2010;42 (8):688-U64 [PubMed]
• Casini Simona, Tan Hanno L., Demirayak Ilker, Remme Carol Ann, Amin Ahmad S., Scicluna Brendon P., Chatyan Houssine, Ruijter Jan M., Bezzina Connie R., van Ginneken Antoni C. G., Veldkamp Marieke W. Tubulin polymerization modifies cardiac sodium channel expression and gating Cardiovascular research 2010;85 (4):691-700 [PubMed]

2009

• Remme Carol Ann, Scicluna Brendon P., Verkerk Arie O., Amin Ahmad S., van Brunschot Sandra, Beekman Leander, Deneer Vera H. M., Chevalier Catherine, Oyama Fumitaka, Miyazaki Haruko, Nukina Nobuyuki, Wilders Ronald, Escande Denis, Houlgatte Remi, Wilde Arthur A. M., Tan Hanno L., Veldkamp Marieke W., de Bakker Jacques M. T., Bezzina Connie R. Genetically Determined Differences in Sodium Current Characteristics Modulate Conduction Disease Severity in Mice With Cardiac Sodium Channelopathy Circulation research 2009;104 (11):1283-U112 [PubMed]
• Pilichou Kalliopi, Remme Carol Ann, Basso Cristina, Campian Maria E., Rizzo Stefania, Barnett Phil, Scicluna Brendon P., Bauce Barbara, van den Hoff Maurice J. B., de Bakker Jacques M. T., Tan Hanno L., Valente Marialuisa, Nava Andrea, Wilde Arthur A. M., Moorman Antoon F. M., Thiene Gaetano, Bezzina Connie R. Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy Journal of experimental medicine 2009;206 (8):1787-1802 [PubMed]
• Remme C. A., Verkerk A. O., Hoogaars W. M. H., Aanhaanen W. T. J., Scicluna B. P., Annink C., van den Hoff M. J. B., Wilde A. A. M., van Veen T. A. B., Veldkamp M. W., de Bakker J. M. T., Christoffels V. M., Bezzina C. R. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium Basic research in cardiology 2009;104 (5):511-522 [PubMed]

2008

• Scicluna Brendon P., Wilde Arthur W., Bezzina Connie R. The primary arrhythmia syndromes: same mutation, different manifestations. Are we starting to understand why? Journal of cardiovascular electrophysiology 2008;19 (4):445-452 [PubMed]