C. Ris-Stalpers PhD publications

foto

Publications PhD C. Ris-Stalpers

Position
Associate Professor
Main activities
Research
Specialisation
Molecular Obstetrics & Molecular Endocrinology
Focus of research

About 25% of all pregnancies are complicated by gestational disease, of which severe hypertension (i.e. early preeclampsia and HELLP syndrome) and preterm labour are the leading cause of pregnancy-related maternal morbidity and mortality and poor neonatal outcome. Although there is consensus that the causal organ for these gestational diseases is the placenta the underlying multifactorial molecular causes and early and reliable clinical biomarkers that explain and predict development of obstetrical disease during the course of pregnancy are not available.

The past years, the department of Obstetrics and Gynaecology of the AMC has (with METC approval) set up an infrastructure called the Preeclampsia And Non-preeclampsia DAtabase (PANDA), in which we collect placental biopsies and maternal and fetal genomic DNA and blood of over 400 pregnancies. This infrastructure has enabled us to carry out several important research projects. We collaborated in a study validating a novel marker for preeclampsia, we have identified a placental signature specific for HELLP syndrome, we have discovered four novel highly placenta specific genes relevant for the development of early and severe preeclampsia and investigated the relation of placental specific spliced variants of the FLT1 gene to gestational hypertensive disease and fetal growth.
 

The PANDA biobanking effort will during 2010 be extended by the collection of myometrium and placental bed biopsies, essential to our further studies on the molecular basis of premature labour and early placentation.

Amsterdam UMC Research Institutes
AMC departments
All publications

2020

  • Koot Marjette H., Grooten Iris J., van der Post Joris A. M., Bais Joke M. J., Ris-Stalpers Carrie, Leeflang Mariska M. G., Bremer Henk A., van der Ham David P., Heidema Wieteke M., Huisjes Anjoke, Kleiverda Gunilla, Kuppens Simone M., van Laar Judith O. E. H., Langenveld Josje, van der Made Flip, van Pampus Mariëlle G., Papatsonis Dimitri, Pelinck Marie-José, Pernet Paula J., van Rheenen-Flach Leonie, Rijnders Robbert J., Scheepers Hubertina C. J., Vogelvang Tatjana E., Mol Ben W., Roseboom Tessa J., Painter Rebecca C. Determinants of disease course and severity in hyperemesis gravidarum European journal of obstetrics, gynecology, and reproductive biology 2020;245:162-167 [PubMed]
  • Koot M. H., Grooten I. J., Post J. A. M. vd, Bais J. M. J., Ris-Stalpers C., Naaktgeboren C. A., Niemeijer M. N., Bremer H. A., van der Ham D. P., Heidema W. M., Huisjes A., Kleiverda G., Kuppens S. M., van Laar J. O. E. H., Langenveld J., van der Made F., Papatsonis D., Pelinck M. J., Pernet P. J., van Rheenen-Flach L., Rijnders R. J., Scheepers H. C. J., Vogelvang T. E., Mol B. W., Roseboom T. J., Painter R. C. Ketonuria is not associated with hyperemesis gravidarum disease severity European journal of obstetrics, gynecology, and reproductive biology 2020;254:315-320 [PubMed]
  • Amraoui Fouad, Hassani Lahsinoui Hajar, Spijkers Leon J. A., Vogt Liffert, Peters Stephan L. M., Wijesinghe Dayanjan S., Warncke Urszula O., Chalfant Charles E., Ris-Stalpers Carrie, van den Born Bert-Jan H., Afink Gijs B. Plasma ceramide is increased and associated with proteinuria in women with pre-eclampsia and HELLP syndrome Pregnancy hypertension 2020;19:100-105 [PubMed]
  • O’Connor Blakely B., Pope Benjamin D., Peters Michael M., Ris-Stalpers Carrie, Parker Kevin K. The role of extracellular matrix in normal and pathological pregnancy: Future applications of microphysiological systems in reproductive medicine Experimental biology and medicine (Maywood, N.J.) 2020;245 (13):1163-1174 [PubMed]

2018

  • Heida Karst Y., Kampman Marlies A., Franx Arie, de Laat Monique W., Mulder Barbara J., van der Post Joris A., Bilardo Catia M., Pieper Petronella G., Sollie Krystyna M., Sieswerda Gertjan T., Ris-Stalpers Carrie, Oudijk Martijn A. Cardiovascular biochemical risk factors among women with spontaneous preterm delivery International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2018;141 (2):206-211 [PubMed]
  • Stalman Susanne E., Solanky Nita, Ishida Miho, Alemán-Charlet Cristina, Abu-Amero Sayeda, Alders Marielle, Alvizi Lucas, Baird William, Demetriou Charalambos, Henneman Peter, James Chela, Knegt Lia C., Leon Lydia J., Mannens Marcel M. A. M., Mul Adi N., Nibbering Nicole A., Peskett Emma, Rezwan Faisal I., Ris-Stalpers Carrie, van der Post Joris A. M., Kamp Gerdine A., Plötz Frans B., Wit Jan M., Stanier Philip, Moore Gudrun E., Hennekam Raoul C. Genetic Analyses in Small for Gestational Age Newborns Journal of clinical endocrinology and metabolism 2018;103 (3):917-925 [PubMed]
  • Fernando Febilla, Boussata Souad, Jongejan Aldo, van der Post Joris A., Afink Gijs, Ris-Stalpers Carrie In silico analysis of the Mus musculus uterine gene expression landscape during pregnancy identifies putative upstream regulators for labour PLoS ONE 2018;13 (9) [PubMed]
  • Ziros Panos G., Habeos Ioannis G., Chartoumpekis Dionysios V., Ntalampyra Eleni, Somm Emmanuel, Renaud C. dric O., Bongiovanni Massimo, Trougakos Ioannis P., Yamamoto Masayuki, Kensler Thomas W., Santisteban Pilar, Carrasco Nancy, Ris-Stalpers Carrie, Amendola Elena, Liao Xiao-Hui, Rossich Luciano, Thomasz Lisa, Juvenal Guillermo J., Refetoff Samuel, Sykiotis Gerasimos P. NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland Thyroid 2018;28 (6):780-798 [PubMed]

2017

  • Grooten Iris J., Koot Marjette H., van der Post Joris Am, Bais Joke Mj, Ris-Stalpers Carrie, Naaktgeboren Christiana, Bremer Henk A., van der Ham David P., Heidema Wieteke M., Huisjes Anjoke, Kleiverda Gunilla, Kuppens Simone, van Laar Judith Oeh, Langenveld Josje, van der Made Flip, van Pampus Mariëlle G., Papatsonis Dimitri, Pelinck Marie-José, Pernet Paula J., van Rheenen Leonie, Rijnders Robbert J., Scheepers Hubertina Cj, Vogelvang Tatjana E., Mol Ben W., Roseboom Tessa J., Painter Rebecca C. Early enteral tube feeding in optimizing treatment of hyperemesis gravidarum: the Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER) randomized controlled trial American journal of clinical nutrition 2017;106 (3):812-820 [PubMed]

2016

  • Karamat Fares A., Oudman Inge, Haan Yentl C., van Kuilenburg Andre B. P., Leen Rene, Danser Jan A. H., Leijten Frank P. J., Ris-Stalpers Carrie, van Montfrans Gert A., Clark Joseph F., Brewster Lizzy M. Creatine kinase inhibition lowers systemic arterial blood pressure in spontaneously hypertensive rats: a randomized controlled trial Journal of hypertension 2016;34 (12):2418-2426 [PubMed]
  • Grooten Iris J., Mol Ben W., van der Post Joris A. M., Ris-Stalpers Carrie, Kok Marjolein, Bais Joke M. J., Bax Caroline J., Duvekot Johannes J., Bremer Henk A., Porath Martina M., Heidema Wieteke M., Bloemenkamp Kitty W. M., Scheepers Hubertina C. J., Franssen Maureen T. M., Oudijk Martijn A., Roseboom Tessa J., Painter Rebecca C. Early nasogastric tube feeding in optimising treatment for hyperemesis gravidarum: the MOTHER randomised controlled trial (Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding) BMC pregnancy and childbirth 2016;16 (1):22 [PubMed]
  • Burke Órlaith, Benton Samantha, Szafranski Pawel, von Dadelszen Peter, Buhimschi S. Catalin, Cetin Irene, Chappell Lucy, Figueras Francesc, Galindo Alberto, Herraiz Ignacio, Holzman Claudia, Hubel Carl, Knudsen Ulla, Kronborg Camilla, Laivuori Hannele, Lapaire Olav, McElrath Thomas, Moertl Manfred, Myers Jenny, Ness Roberta B., Oliveira Leandro, Olson Gayle, Poston Lucilla, Ris-Stalpers Carrie, Roberts James M., Schalekamp-Timmermans Sarah, Schlembach Dietmar, Steegers Eric, Stepan Holger, Tsatsaris Vassilis, van der Post Joris A., Verlohren Stefan, Villa Pia M., Williams David, Zeisler Harald, Redman Christopher W. G., Staff Anne Cathrine Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms Pregnancy hypertension 2016;6 (1):53-59 [PubMed]
  • Prins J. R., van der Hoorn M. L. P., Keijser R., Ris-Stalpers C., van Beelen E., Afink G. B., Claas F. H. J., van der Post J. A. M., Scherjon S. A. Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia Human immunology 2016;77 (1):68-70 [PubMed]

2015

  • Kremer Andreas E., Bolier Ruth, Dixon Peter H., Geenes Victoria, Chambers Jenny, Tolenaars Dagmar, Ris-Stalpers Carrie, Kaess Bernhard M., Rust Christian, van der Post Joris A., Williamson Catherine, Beuers Ulrich, Oude Elferink Ronald P. J. Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy Journal of hepatology 2015;62 (4):897-904 [PubMed]
  • Jebbink J. M., Boot R. G., Keijser R., Moerland P. D., Aten J., Veenboer G. J. M., van Wely M., Buimer M., Ver Loren van Themaat E., Aerts J. M. F. G., van der Post J. A. M., Afink G. B., Ris-Stalpers C. Increased glucocerebrosidase expression and activity in preeclamptic placenta Placenta 2015;36 (2):160-169 [PubMed]
  • Kampman M. A. M., Bilardo C. M., Mulder B. J. M., Aarnoudse J. G., Ris-Stalpers C., van Veldhuisen D. J., Pieper P. G. Maternal cardiac function, uteroplacental Doppler flow parameters and pregnancy outcome: a systematic review Ultrasound in obstetrics & gynecology 2015;46 (1):21-28 [PubMed]
  • van Uitert Miranda, Moerland Perry D., Enquobahrie Daniel A., Laivuori Hannele, van der Post Joris A. M., Ris-Stalpers Carrie, Afink Gijs B. Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia PLoS ONE 2015;10 (7):e0132468 [PubMed]
  • Vissenberg R., Manders V. D., Mastenbroek S., Fliers E., Afink G. B., Ris-Stalpers C., Goddijn M., Bisschop P. H. Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction Human reproduction update 2015;21 (3):378-387 [PubMed]
  • Amraoui F., Hassani Lahsinoui H., Boussata S., Keijser R., Veenboer G. J. M., Middeldorp S., van der Post J. A. M., Ris-Stalpers C., Afink G. B., van den Born B. J. H. Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in normotensive and pre-eclamptic pregnancies Placenta 2015;36 (11):1218-1224 [PubMed]
  • Fernando Febilla, Keijser Remco, Henneman Peter, van der Kevie-Kersemaekers Anne-Marie F., Mannens Marcel Mam, van der Post Joris Am, Afink Gijs B., Ris-Stalpers Carrie The idiopathic preterm delivery methylation profile in umbilical cord blood DNA BMC genomics 2015;16 (1):736 [PubMed]
  • Jebbink Jiska, Veenboer Geertruda, Boussata Souad, Keijser Remco, Kremer Andreas E., Elferink Ronald Oude, van der Post Joris, Afink Gijs, Ris-Stalpers Carrie Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015;1852 (1):131-136 [PubMed]

2014

  • Jebbink Jiska, Tabbers Merit, Afink Gijs, Beuers Ulrich, Oude Elferink Ronald, Ris-Stalpers Carrie, van der Post Joris HELLP syndrome preceded by intrahepatic cholestasis of pregnancy: one serious itch BMJ case reports 2014;2014:bcr2013203208 [PubMed]
  • Jebbink Jiska Maren Preeclamptic disorders of pregnancy; Novel molecular insights 2014. 159p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van der Post J. A. M.; Co-supervisors: Afink G. B., Ris-Stalpers C.)
  • Karamat Fares A., Oudman Inge, Ris-Stalpers Carrie, Afink Gijs B., Keijser Remco, Clark Joseph F., van Montfrans Gert A., Brewster Lizzy M. Resistance artery creatine kinase mRNA and blood pressure in humans Hypertension 2014;63 (1):68-73 [PubMed]
  • Amraoui Fouad, Spijkers Léon, Hassani Lahsinoui Hajar, Vogt Liffert, van der Post Joris, Peters Stephan, Afink Gijs, Ris-Stalpers Carrie, van den Born Bert-Jan SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice PLoS ONE 2014;9 (3):e91897 [PubMed]

2013

  • Böing A. N., Stap J., Hau C. M., Afink G. B., Ris-Stalpers C., Reits E. A., Sturk A., van Noorden C. J. F., Nieuwland R. Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2013;1833 (8):1844-1852 [PubMed]
  • Kleinrouweler C. Emily, van Uitert Miranda, Moerland Perry D., Ris-Stalpers Carrie, van der Post Joris A. M., Afink Gijs B. Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis PLoS ONE 2013;8 (7):e68991 [PubMed]
  • Ris-Stalpers Carrie Maternal circulating PlGF concentrations and placenta-related pregnancy complications: First results from the CoLab AngF Study Pregnancy hypertension 2013
  • de Laat Monique W. M., Pieper Petronella G., Oudijk Martijn A., Mulder Barbara J. M., Christoffels Vincent M., Afink Gijs B., Postma Alex V., Ris-Stalpers Carrie The clinical and molecular relations between idiopathic preterm labor and maternal congenital heart defects Reproductive sciences (Thousand Oaks, Calif.) 2013;20 (2):190-201 [PubMed]

2012

  • Kleinrouweler C. E., Wiegerinck M. M. J., Ris-Stalpers C., Bossuyt P. M. M., van der Post J. A. M., von Dadelszen P., Mol B. W. J., Pajkrt E., Mignini L., Magee L., Sawchuck D., Gao E., Oude Rengerink K., Zamora J., Fox C., Daniels J., Khan K. S., Thangaratinam S., Meads C. Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis BJOG 2012;119 (7):778-787 [PubMed]
  • Holwerda K. M., Bos E. M., Rajakumar A., Ris-Stalpers C., van Pampus M. G., Timmer A., Erwich J. J. H. M., Faas M. M., van Goor H., Lely A. T. Hydrogen sulfide producing enzymes in pregnancy and preeclampsia Placenta 2012;33 (6):518-521 [PubMed]
  • Jebbink Jiska, Wolters Astrid, Fernando Febilla, Afink Gijs, van der Post Joris, Ris-Stalpers Carrie Molecular genetics of preeclampsia and HELLP syndrome - A review BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (12):1960-1969 [PubMed]

2011

  • Verheul Jorieke C., Ris-Stalpers Carrie, Bikker Hennie, Bakker-van Waarde Willie M., Noordam Cees Congenitaal hyperinsulinisme in Noordoost-Nederland. Klinische kenmerken en DNA-diagnostiek bij 22 kinderen Nederlands tijdschrift voor geneeskunde 2011;155 (32):A3343 [PubMed]
  • Jebbink Jiska, Keijser Remco, Veenboer Geertruda, van der Post Joris, Ris-Stalpers Carrie, Afink Gijs Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth Hypertension 2011;58 (1):70-U129 [PubMed]
  • Zwaveling-Soonawala N., Hagebeuk E. E., Slingerland A. S., Ris-Stalpers C., Vulsma T., van Trotsenburg A. S. Successful transfer to sulfonylurea therapy in an infant with developmental delay, epilepsy and neonatal diabetes (DEND) syndrome and a novel ABCC8 gene mutation Diabetologia 2011;54 (2):469-471 [PubMed]

2010

  • Di Palma Tina, Zampella Emilia, Filippone Maria Grazia, Macchia Paolo Emidio, Ris-Stalpers Carrie, de Vroede Monique, Zannini Mariastella Characterization of a novel loss-of-function mutation of PAX8 associated with congenital hypothyroidism Clinical endocrinology 2010;73 (6):808-814 [PubMed]
  • Ris-Stalpers Carrie, Bikker Hennie Genetics and phenomics of hypothyroidism and goiter due to TPO mutations Molecular and cellular endocrinology 2010;322 (1-2):38-43 [PubMed]
  • Afink Gijs B., Veenboer Geertruda, de Randamie Janine, Keijser Remco, Meischl Christof, Niessen Hans, Ris-Stalpers Carrie Initial Characterization of C16orf89, A Novel Thyroid-Specific Gene Thyroid 2010;20 (7):811-821 [PubMed]
  • Klaassens M., Blom E. W., Schrander J. J. P., Ris-Stalpers C., Nieuwenhuijzen Kruseman A. C., van Steensel M. A. M., Schrander-Stumpel C. T. R. M. Unique skin changes in a case of Albright hereditary osteodystrophy caused by a rare GNAS1 mutation British journal of dermatology 2010;162 (3):690-694 [PubMed]

2008

  • Meischl Christof, Buermans Henk P., Hazes Thierry, Zuidwijk Marian J., Musters René J. P., Boer Christa, van Lingen Arthur, Simonides Warner S., Blankenstein Marinus A., Dupuy Corrine, Paulus Walter J., Hack C. Erik, Ris-Stalpers Carrie, Roos Dirk, Niessen Hans W. M. H9c2 cardiomyoblasts produce thyroid hormone American journal of physiology. Cell physiology 2008;294 (5):C1227-C1233 [PubMed]
  • Afink Gijs, Kulik Willem, Overmars Henk, de Randamie Janine, Veenboer Truus, van Cruchten Arno, Craen Margarita, Ris-Stalpers Carrie Molecular characterization of iodotyrosine dehalogenase deficiency in patients with hypothyroidism Journal of clinical endocrinology and metabolism 2008;93 (12):4894-4901 [PubMed]
  • Buimer M., Lok C. A. R., Nieuwland R., Ris-Stalpers C., van der Post J. A. M. Placental corticotrophin-releasing hormone mRNA and microparticles in maternal plasma are not measures of placental shedding of debris: a rebuttal Journal of thrombosis and haemostasis 2008;6 (10):1837-8; author reply 1838-9 [PubMed]
  • Buimer M., Keijser R., Jebbink J. M., Wehkamp D., van Kampen A. H. C., Boer K., van der Post J. A. M., Ris-Stalpers C. Seven placental transcripts characterize HELLP-syndrome Placenta 2008;29 (5):444-453 [PubMed]
  • Buimer Maarten The placenta as modulator of fetal prosperity 2008. 175p. ISBN 9789090230337. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van der Post J. A. M., Kok J. H.; Co-supervisors: Ris-Stalpers C., van Wassenaer-Leemhuis A. G.)

2007

  • Tenenbaum-Rakover Yardena, Mamanasiri Sunee, Ris-Stalpers Carrie, German Alina, Sack Joseph, Allon-Shalev Stavit, Pohlenz Joachim, Refetoff Samuel Clinical and genetic characteristics of congenital hypothyroidism due to mutations in the thyroid peroxidase (TPO) gene in Israelis Clinical endocrinology 2007;66 (5):695-702 [PubMed]
  • Iglesias-Platas Isabel, Monk David, Jebbink Jiska, Buimer Maarten, Boer Kees, van der Post Joris, Hills Frank, Apostolidou Sophia, Ris-Stalpers Carrie, Stanier Philip, Moore Gudrun E. STOX1 is not imprinted and is not likely to be involved in preeclampsia Nature genetics 2007;39 (3):279-80; author reply 280-1 [PubMed]

2006

  • Ris-Stalpers Carrie Physiology and pathophysiology of the DUOXes Antioxidants & redox signaling 2006;8 (9-10):1563-1572 [PubMed]

2004

  • Pauws Erwin, Sijmons Gwendolyn G., Yaka Cigdem, Ris-Stalpers Carrie A novel homeobox gene overexpressed in thyroid carcinoma Thyroid 2004;14 (7):500-505 [PubMed]
  • Pauws Erwin, Veenboer Geertruda J. M., Smit Jan W. A., de Vijlder Jan J. M., Morreau Hans, Ris-Stalpers Carrie Genes differentially expressed in thyroid carcinoma identified by comparison of SAGE expression profiles FASEB journal 2004;18 (3):560-561 [PubMed]

2003

  • Pauws E. Gene expression in thyroid and thyroid cancer 2003. 143p. ISBN 9789090168951. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Vijlder J. J. M.; Co-supervisor: Ris-Stalpers C.)
  • Moreno José C., de Vijlder Jan J. M., Vulsma Thomas, Ris-Stalpers Carrie Genetic basis of hypothyroidism: recent advances, gaps and strategies for future research Trends in endocrinology and metabolism: TEM 2003;14 (7):318-326 [PubMed]
  • Moreno Navarro J. C. Novel thyroid specific transcripts identified by SAGE: implication for congenital hypothyroidism 2003. 186p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: de Vijlder J. J. M.; Co-supervisor: Ris-Stalpers C.)

2002

  • de Vijlder J. J. M., Ris-Stalpers C., Vulsma T. Congenitale hypothyreoide: belang van bepaling van jodium en jodiumhoudende verbindingen in urine Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde 2002;27:261-265
  • De Vijlder J. J.M., Ris-Stalpers C., Vulsma T. Congenitale hypothyreoïdie: Belang van bepaling van jodium en jodiumhoudende verbindingen in urine Nederlands Tijdschrift voor de Klinische Chemie 2002;27 (6):261-265
  • Moreno José C., Bikker Hennie, Kempers Marlies J. E., van Trotsenburg A. S. Paul, Baas Frank, de Vijlder Jan J. M., Vulsma Thomas, Ris-Stalpers C. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism New England journal of medicine 2002;347 (2):95-102 [PubMed]
  • van Wassenaer Aleid G., Stulp Maykel R., Valianpour Fredoen, Tamminga Pieter, Ris Stalpers Carrie, de Randamie Janine S. E., van Beusekom Christien, de Vijlder Jan J. M. The quantity of thyroid hormone in human milk is too low to influence plasma thyroid hormone levels in the very preterm infant Clinical endocrinology 2002;56 (5):621-627 [PubMed]

2001

  • Pauws E., Tummers R. F., Ris-Stalpers C., de Vijlder J. J., Voûte T. Absence of activating mutations in ras and gsp oncogenes in a cohort of nine patients with sporadic pediatric thyroid tumors Medical and pediatric oncology 2001;36 (6):630-634 [PubMed]
  • Moreno J. C., Pauws E., van Kampen A. H., Jedlicková M., de Vijlder J. J., Ris-Stalpers C. Cloning of tissue-specific genes using serial analysis of gene expression and a novel computational substraction approach Genomics 2001;75 (1-3):70-76 [PubMed]
  • Pauws E., van Kampen A. H., van de Graaf S. A., de Vijlder J. J., Ris-Stalpers C. Heterogeneity in polyadenylation cleavage sites in mammalian mRNA sequences: implications for SAGE analysis Nucleic acids research 2001;29 (8):1690-1694 [PubMed]
  • Konings C. H., van Trotsenburg A. S., Ris-Stalpers C., Vulsma T., Wiedijk B. M., de Vijlder J. J. Plasma thyrotropin bioactivity in Down's syndrome children with subclinical hypothyroidism European journal of endocrinology / European Federation of Endocrine Societies 2001;144 (1):1-4 [PubMed]
  • van de Graaf S. A., Ris-Stalpers C., Pauws E., Mendive F. M., Targovnik H. M., de Vijlder J. J. Up to date with human thyroglobulin Journal of endocrinology 2001;170 (2):307-321 [PubMed]

2000

  • Eussen B. H., Bartalini G., Bakker L., Balestri P., Di Lucca C., van Hemel J. O., Dauwerse H., van den Ouweland A. M., Ris-Stalpers C., Verhoef S., Halley D. J., Fois A. An unbalanced submicroscopic translocation t(8;16)(q24.3;p13.3)pat associated with tuberous sclerosis complex, adult polycystic kidney disease, and hypomelanosis of Ito Journal of medical genetics 2000;37 (4):287-291 [PubMed]
  • Pauws E., Moreno J. C., Tijssen M., Baas F., de Vijlder J. J., Ris-Stalpers C. Serial analysis of gene expression as a tool to assess the human thyroid expression profile and to identify novel thyroidal genes Journal of clinical endocrinology and metabolism 2000;85 (5):1923-1927 [PubMed]

1999

  • van de Graaf S. A., Ris-Stalpers C., Veenboer G. J., Cammenga M., Santos C., Targovnik H. M., de Vijlder J. J., Medeiros-Neto G. A premature stopcodon in thyroglobulin messenger RNA results in familial goiter and moderate hypothyroidism Journal of clinical endocrinology and metabolism 1999;84 (7):2537-2542 [PubMed]
  • de Vijlder J. J., Ris-Stalpers C., Vulsma T. On the origin of circulating thyroglobulin European journal of endocrinology / European Federation of Endocrine Societies 1999;140 (1):7-8 [PubMed]
  • van de Graaf S. A., Cammenga M., Ponne N. J., Veenboer G. J., Gons M. H., Orgiazzi J., de Vijlder J. J., Ris-Stalpers C. The screening for mutations in the thyroglobulin cDNA from six patients with congenital hypothyroidism Biochimie 1999;81 (5):425-432 [PubMed]

1998

  • Bakker O., Razaki H., de Jong J., Ris-Stalpers C., Wiersinga W. M. Expression of the alpha 1, alpha 2, and beta 1 T3-receptor mRNAs in the fasted rat measured using competitive PCR Biochemical and biophysical research communications 1998;242 (3):492-496 [PubMed]
  • Stulp M. R., de Vijlder J. J., Ris-Stalpers C. Placental iodothyronine deiodinase III and II ratios, mRNA expression compared to enzyme activity Molecular and cellular endocrinology 1998;142 (1-2):67-73 [PubMed]
  • van Hauwe P., Everett L. A., Coucke P., Scott D. A., Kraft M. L., Ris-Stalpers C., Bolder C., Otten B., de Vijlder J. J., Dietrich N. L., Ramesh A., Srisailapathy S. C., Parving A., Cremers C. W., Willems P. J., Smith R. J., Green E. D., van Camp G. Two frequent missense mutations in Pendred syndrome Human molecular genetics 1998;7 (7):1099-1104 [PubMed]

1997

  • de Vijlder J. J., Ris-Stalpers C., Vulsma T. Inborn errors of thyroid hormone biosynthesis Experimental and clinical endocrinology & diabetes 1997;105 (Suppl. 4):32-37 [PubMed]
  • De Vijlder Jan J.M., Bikker Hennie, Ris-Stalpers Carrie, Vulsma Thomas Structure, function, and relevance of thyroid peroxidase in inherited diseases of the thyroid Current opinion in endocrinology and diabetes 1997;4 (5):328-332
  • van de Graaf S. A., Pauws E., de Vijlder J. J., Ris-Stalpers C. R. The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells European journal of endocrinology / European Federation of Endocrine Societies 1997;136 (5):508-515 [PubMed]

1996

  • Brinkmann A., Jenster G., Ris-Stalpers C., van der Korput H., Brüggenwirth H., Boehmer A., Trapman J. Molecular basis of androgen insensitivity Steroids 1996;61 (4):172-175 [PubMed]
  • Koopdonk-Kool J. M., de Vijlder J. J., Veenboer G. J., Ris-Stalpers C., Kok J. H., Vulsma T., Boer K., Visser T. J. Type II and type III deiodinase activity in human placenta as a function of gestational age Journal of clinical endocrinology and metabolism 1996;81 (6):2154-2158 [PubMed]

1995

  • Brinkmann A. O., Jenster G., Ris-Stalpers C., van der Korput J. A., Brüggenwirth H. T., Boehmer A. L., Trapman J. Androgen receptor mutations Journal of steroid biochemistry and molecular biology 1995;53 (1-6):443-448 [PubMed]
  • den Hartog M. T., Sijmons C. C., Bakker O., Ris-Stalpers C., de Vijlder J. J. Importance of the content and localization of tyrosine residues for thyroxine formation within the N-terminal part of human thyroglobulin European journal of endocrinology / European Federation of Endocrine Societies 1995;132 (5):611-617 [PubMed]

1994

  • Ris-Stalpers C., Hoogenboezem T., Sleddens H. F., Verleun-Mooijman M. C., Degenhart H. J., Drop S. L., Halley D. J., Oosterwijk J. C., Hodgins M. B., Trapman J. A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with x-linked androgen insensitivity Pediatric research 1994;36 (2):227-234 [PubMed]
  • Ris-Stalpers C., Verleun-Mooijman M. C., de Blaeij T. J., Degenhart H. J., Trapman J., Brinkmann A. O. Differential splicing of human androgen receptor pre-mRNA in X-linked Reifenstein syndrome, because of a deletion involving a putative branch site American journal of human genetics 1994;54 (4):609-617 [PubMed]

1993

  • Ris-Stalpers C., Turberg A., Verleun-Mooyman M. C., Romalo G., Schweikert H. U., Trapman J., Brinkmann A. O. Expression of an aberrantly spliced androgen receptor mRNA in a family with complete androgen insensitivity Annals of the New York Academy of Sciences 1993;684:239-242 [PubMed]
  • Ris-Stalpers C., Verleun-Mooijman M. C., Trapman J., Brinkmann A. O. Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity Biochemical and biophysical research communications 1993;196 (1):173-180 [PubMed]

1992

  • Veldscholte J., Berrevoets C. A., Ris-Stalpers C., Kuiper G. G., Jenster G., Trapman J., Brinkmann A. O., Mulder E. The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens Journal of steroid biochemistry and molecular biology 1992;41 (3-8):665-669 [PubMed]

1991

  • Brinkmann A. O., Kuiper G. G., Ris-Stalpers C., van Rooij H. C., Romalo G., Trifiro M., Mulder E., Pinsky L., Schweikert H. U., Trapman J. Androgen receptor abnormalities Journal of steroid biochemistry and molecular biology 1991;40 (1-3):349-352 [PubMed]
  • Ris-Stalpers C., Trifiro M. A., Kuiper G. G., Jenster G., Romalo G., Sai T., van Rooij H. C., Kaufman M., Rosenfield R. L., Liao S. Substitution of aspartic acid-686 by histidine or asparagine in the human androgen receptor leads to a functionally inactive protein with altered hormone-binding characteristics Molecular endocrinology (Baltimore, Md.) 1991;5 (10):1562-1569 [PubMed]

1990

  • Ris-Stalpers C., Kuiper G. G., Faber P. W., Schweikert H. U., van Rooij H. C., Zegers N. D., Hodgins M. B., Degenhart H. J., Trapman J., Brinkmann A. O. Aberrant splicing of androgen receptor mRNA results in synthesis of a nonfunctional receptor protein in a patient with androgen insensitivity Proceedings of the National Academy of Sciences of the United States of America 1990;87 (20):7866-7870 [PubMed]
  • Veldscholte J., Ris-Stalpers C., Kuiper G. G., Jenster G., Berrevoets C., Claassen E., van Rooij H. C., Trapman J., Brinkmann A. O., Mulder E. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens Biochemical and biophysical research communications 1990;173 (2):534-540 [PubMed]
  • Trapman J., Ris-Stalpers C., van der Korput J. A., Kuiper G. G., Faber P. W., Romijn J. C., Mulder E., Brinkmann A. O. The androgen receptor: functional structure and expression in transplanted human prostate tumors and prostate tumor cell lines Journal of steroid biochemistry and molecular biology 1990;37 (6):837-842 [PubMed]

1989

  • Kuiper G. G., Faber P. W., van Rooij H. C., van der Korput J. A., Ris-Stalpers C., Klaassen P., Trapman J., Brinkmann A. O. Structural organization of the human androgen receptor gene Journal of molecular endocrinology 1989;2 (3):R1-R4 [PubMed]
back to PhD C. Ris-Stalpers