C.M. van Drunen PhD publications

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Publications PhD C.M. van Drunen

Position
Assistant Professor
Main activities
Research, Other
Specialisation
Molecular Immunology
Focus of research

Background
There is a growing awareness that the initiation of the immune response by inflammatory cells, like dendritic cells (DC), takes place with the context of the local mucosal surface. All signals derived from the environment or from local tissue, are integrated, ultimately defining the immune response. Within the ENT department we study this process in relation to the pathology of allergy and chronic rhinosinusitis.

Allergy
We have shown that at birth the local immune system is immature and that this is characterized by local production of a mediator. The level of this regulatory cytokine in epithelial cells and endothelial cells is directly correlated with the level of symptoms in allergic individuals. We have shown that nasal epithelium cells in allergic individuals is in an constant activated state and that secreted mediators may affect function and dynamics of tissue resident dendritic cells.

Chronic rhinosinusitis
Chronic rhinosinusitis is a common inflammatory disease of the nasal mucosa that strongly impacts on the life of patients. The pathogenesis of the disease is unknown, but is associated with diverse co-morbidities, including asthma. Using diverse approaches we study underlying pathological mechanisms focussing on the role of micro-organisms and the role of epithelium-fibroblast interactions

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Golebski Korneliusz, Layhadi Janice A., Sahiner Umit, Steveling-Klein Esther H., Lenormand Madison M., Li Rachael C. Y., Bal Suzanne M., Heesters Balthasar A., Vilà-Nadal Gemma, Hunewald Oliver, Montamat Guillem, He Feng Q., Ollert Markus, Fedina Oleksandra, Lao-Araya Mongkol, Vijverberg Susanne J. H., Maitland-van der Zee Anke-Hilse, van Drunen Cornelis M., Fokkens Wytske J., Durham Stephen R., Spits Hergen, Shamji Mohamed H. Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response Immunity 2021;54 (2):291-307.e7 [PubMed]

2020

  • Hoepel Willianne, Golebski Korneliusz, van Drunen Cornelis M., den Dunnen Jeroen Active control of mucosal tolerance and inflammation by human IgA and IgG antibodies Journal of allergy and clinical immunology 2020;146 (2):273-275 [PubMed]
  • Golebski Korneliusz, Kabesch Michael, Melén Erik, Potočnik Uroš, van Drunen Cornelis M, Reinartz Susanne, Maitland-van der Zee Anke H, Vijverberg Susanne J H Childhood asthma in the new omics era: challenges and perspectives: Erratum Current opinion in allergy and clinical immunology 2020;20 (4):155-161 [PubMed]
  • van Drunen Cornelis M, Fokkens Wytske J., Hellings Peter W. International Consensus Statement on Rhinology and Allergy: Rhinosinusitis International forum of allergy & rhinology 2020
  • Segboer Christine L. Title Etiology, diagnosis and treatment of non-allergic rhinitis 2020. 409p. ISBN 9789402818987. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens Wytske J.; Co-supervisors: Terreehorst Ingrid, van Drunen Kees M.)

2019

  • Perotin Jeanne-Marie, Schofield James P. R., Wilson Susan J., Ward Jonathan, Brandsma Joost, Strazzeri Fabio, Bansal Aruna, Yang Xian, Rowe Anthony, Corfield Julie, Lutter Rene, Shaw Dominick E., Bakke Per S., Caruso Massimo, Dahlén Barbro, Fowler Stephen J., Horváth Ildikó, Howarth Peter, Krug Norbert, Montuschi Paolo, Sanak Marek, Sandström Thomas, Sun Kai, Pandis Ioannis, Auffray Charles, de Meulder Bertrand, Lefaudeux Diane, Riley John H., Sousa Ana R., Dahlen Sven-Erik, Adcock Ian M., Chung Kian Fan, Sterk Peter J., Skipp Paul J., Collins Jane E., Davies Donna E., Djukanović Ratko, Adcock I. M., Ahmed H., Auffray C., Bakke P., Banssal A. T., Baribaud F., Bates S., Bel E. H., Bigler J., Sterk P. J., van Aalderen W. M., van Drunen C. M., Zwinderman A. H. Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux European respiratory journal 2019;53 (6) [PubMed]
  • Fokkens W., Desrosiers M., Harvey R., Hopkins C., Mullol J., Philpott C., Alobid I., Anselmo-Lima W. T., Bachert C., Baroody F., Bernal-Sprekelsen M., von Buchwald C., Cervin A., Cohen N., Constantinidis J., de Gabory L., Douglas R., Gevaert P., Hafner A., Hellings P., Joos G., Kalogjera L., Kern R., Knill A., Kocks J., Landis B. N., Limpens J., Lebeer S., Lourenco O., Matricardi P. M., Meco C., O Mahony L., Reitsma S., Ryan D., Schlosser R., Senior B., Smith T., Teeling T., Tomazic P. V., Toppila-Salmi S., Wang D. Y., Wang D., Zhang L., Lund V., van Drunen Cornelis EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis Rhinology 2019;57 (3):162-168 [PubMed]
  • Golebski K., Hoepel W., van Egmond D., de Groot E. J., Amatngalim G. D., Beekman J. M., Fokkens W. J., van Drunen C. M., den Dunnen J. FcγRIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4 Mucosal immunology 2019;12 (2):425-433 [PubMed]
  • Östling J. rgen, van Geest Marleen, Schofield James P. R., Jevnikar Zala, Wilson Susan, Ward Jonathan, Lutter Rene, Shaw Dominick E., Bakke Per S., Caruso Massimo, Dahlen Sven-Erik, Fowler Stephen J., Horváth Ildikó, Krug Norbert, Montuschi Paolo, Sanak Marek, Sandström Thomas, Sun Kai, Pandis Ioannis, Auffray Charles, Sousa Ana R., Guo Yike, Adcock Ian M., Howarth Peter, Chung Kian Fan, Bigler Jeanette, Sterk Peter J., Skipp Paul J., Djukanović Ratko, Vaarala Outi, Adcock I. M., Ahmed H., Auffray C., Bakke P., Bansal A. T., Baribaud F., Bates S., Bel E. H., Bigler J., Bisgaard H., Boedigheimer M. J., Bønnelykke K., Brandsma J., Brinkman P., Bucchioni E., Sterk P. J., van Aalderen W. M., Dijkhuis Annemiek, van Drunen C. M., Zwinderman A. H. IL-17–high asthma with features of a psoriasis immunophenotype Journal of allergy and clinical immunology 2019;144 (5):1198-1213 [PubMed]
  • Golebski Korneliusz, Ros Xavier R., Nagasawa Maho, van Tol Sophie, Heesters Balthasar A., Aglmous Hajar, Kradolfer Chantal M. A., Shikhagaie Medya M., Seys Sven, Hellings P. W., van Drunen Cornelis M., Fokkens Wytske J., Spits Hergen, Bal Suzanne M. IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation Nature communications 2019;10 (1) [PubMed]
  • Cornet Marjolein E, Kostamo Katriina, Rinia Albert B, Zwinderman Aeilko H, van Egmond Danielle, de Groot Esther J J, Fokkens Wytske J, van Drunen Cornelis M Novel roles for nasal epithelium in the pathogenesis of chronic rhinosinusitis with nasal polyps Rhinology 2019;57 (3):169-179 [PubMed]
  • Schofield James P. R., Burg Dominic, Nicholas Ben, Strazzeri Fabio, Brandsma Joost, Staykova Doroteya, Folisi Caterina, Bansal Aruna T., Xian Yang, Guo Yike, Rowe Anthony, Corfield Julie, Wilson Susan, Ward Jonathan, Lutter Rene, Shaw Dominick E., Bakke Per S., Caruso Massimo, Dahlen Sven-Erik, Fowler Stephen J., Horváth Ildikó, Howarth Peter, Krug Norbert, Montuschi Paolo, Sanak Marek, Sandström Thomas, Sun Kai, Pandis Ioannis, Riley John, Auffray Charles, de Meulder Bertrand, Lefaudeux Diane, Sousa Ana R., Adcock Ian M., Chung Kian Fan, Sterk Peter J., Skipp Paul J., Djukanović Ratko, Ahmed H., Allen D., Badorrek P., Ballereau S., Baribaud F., Bedding A., Behndig A. F., Berglind A., Berton A., van Aalderen W. M., van Drunen C. M., Zwinderman A. H. Stratification of asthma phenotypes by airway proteomic signatures Journal of allergy and clinical immunology 2019;144 (1):70-82 [PubMed]
  • Khan A., Huynh T. M. T., Vandeplas G., Joish V. N., Mannent L. P., Tomassen P., van Zele T., Cardell L. O., Arebro J., Olze H., Forster-Ruhrmann U., Kowalski M. L., Olszewska-Ziaber A., Fokkens W., van Drunen C., Mullol J., Alobid I., Hellings P. W., Hox V., Toskala E., Scadding G., Lund V., Bachert C. The GALEN rhinosinusitis cohort: chronic rhinosinusitis with nasal polyps affects health-related quality of life Rhinology 2019;57 (5):343-351 [PubMed]
  • Khan A., Vandeplas G., Huynh T. M. T., Joish V. N., Mannent L., Tomassen P., van Zele T., Cardell L. O., Arebro J., Olze H., Foerster-Ruhrmann U., Kowalski M. L., Olszewska-Ziaber A., Holtappels G., de Ruyck N., van Drunen C., Mullol J., Hellings P. W., Hox V., Toskala E., Scadding G., Lund V. J., Fokkens W. J., Bachert C. The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps Rhinology 2019;57 (1):32-42 [PubMed]

2018

  • de Meulder Bertrand, Lefaudeux Diane, Bansal Aruna T., Mazein Alexander, Chaiboonchoe Amphun, Ahmed Hassan, Balaur Irina, Saqi Mansoor, Pellet Johann, Ballereau Stéphane, Lemonnier Nathanaël, Sun Kai, Pandis Ioannis, Yang Xian, Batuwitage Manohara, Kretsos Kosmas, van Eyll Jonathan, Bedding Alun, Davison Timothy, Dodson Paul, Larminie Christopher, Postle Anthony, Corfield Julie, Djukanovic Ratko, Chung Kian Fan, Adcock Ian M., Guo Yi-Ke, Sterk Peter J., Manta Alexander, Rowe Anthony, Baribaud Frédéric, Auffray Charles, Gibeon David, Hoda Uruj, Kuo Scott, Meah Sally, Meiser Andrea, Fleming Louise J., Hu Sile, Pavlidis Stelios, Rossios Christos, Russel Kirsty, Bel Elisabeth, Brinkman Paul, Dijkhuis Annemiek, Hashimoto Simone, Lutter Rene, van Aalderen Wim, van Drunen Kees, Zwinderman Koos A computational framework for complex disease stratification from multiple large-scale datasets BMC systems biology 2018;12 (1) [PubMed]
  • Hoffmans Ruth, Wagemakers Alex, van Drunen Cornelis, Hellings Peter, Fokkens Wytske Acute and chronic rhinosinusitis and allergic rhinitis in relation to comorbidity, ethnicity and environment PLoS ONE 2018;13 (2):e0192330 [PubMed]
  • Segboer Christine L., Fokkens Wytske J., Terreehorst Ingrid, van Drunen Cornelis M. Endotyping of non-allergic, allergic and mixed rhinitis patients using a broad panel of biomarkers in nasal secretions PLoS ONE 2018;13 (7) [PubMed]
  • Segboer Christine L., Terreehorst Ingrid, Gevorgyan Artur, Hellings Peter W., van Drunen Cornelis M., Fokkens Wytske J. Quality of life is significantly impaired in non-allergic rhinitis patients Allergy 2018;73 (5):1094-1100 [PubMed]

2017

  • Cornet Marjolein E. Nasal polyposis: Advances in diagnosis and management: Advances in diagnosis and management 2017. 185p. ISBN 9789461828156. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens W. J.; Co-supervisor: van Drunen C. M.)
  • Gołębski Korneliusz Regulation and cross-talk between environmental triggers of local immune responses in airway epithelial cells 2017. 187p. ISBN 9789461827586. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens W. J.; Co-supervisor: van Drunen C. M.)
  • Lefaudeux Diane, de Meulder Bertrand, Loza Matthew J., Peffer Nancy, Rowe Anthony, Baribaud Frédéric, Bansal Aruna T., Lutter Rene, Sousa Ana R., Corfield Julie, Pandis Ioannis, Bakke Per S., Caruso Massimo, Chanez Pascal, Dahlén Sven-Erik, Fleming Louise J., Fowler Stephen J., Horvath Ildiko, Krug Norbert, Montuschi Paolo, Sanak Marek, Sandstrom Thomas, Shaw Dominic E., Singer Florian, Sterk Peter J., Roberts Graham, Adcock Ian M., Djukanovic Ratko, Auffray Charles, Chung Kian Fan, Adriaens Nora, Ahmed Hassan, Aliprantis Antonios, Alving Kjell, Badorek Philipp, Balgoma David, Barber Clair, Bautmans An, Behndig Annelie F., Bel Elisabeth, Beleta Jorge, Berglind Ann, Berton Alix, Bigler Jeanette, Bisgaard Hans, Brinkman Paul, Dijkhuis Annemiek, Hashimoto Simone, van Drunen Kees, Zwinderman Koos U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics Journal of allergy and clinical immunology 2017;139 (6):1797-1807 [PubMed]

2016

  • Wagener Ariane H. Biomarker discovery for asthma phenotyping: From gene expression to the clinic 2016. 267p. ISBN 9789461697783. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Sterk P. J., Zwinderman A. H.; Co-supervisor: van Drunen C. M.)
  • Reinartz Susanne M., van Tongeren Joost, van Egmond Danielle, de Groot Esther J. J., Fokkens Wytske J., van Drunen Cornelis M. Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects PLoS ONE 2016;11 (5):e0154409 [PubMed]
  • Bal Suzanne M., Bernink Jochem H., Nagasawa Maho, Groot Jelle, Shikhagaie Medya M., Golebski Kornel, van Drunen Cornelis M., Lutter Rene, Jonkers Rene E., Hombrink Pleun, Bruchard Melanie, Villaudy Julien, Munneke J. Marius, Fokkens Wytske, Erjefält Jonas S., Spits Hergen, Ros Xavier Romero IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs Nature immunology 2016;17 (6):636-645 [PubMed]
  • Tomassen Peter, Vandeplas Griet, van Zele Thibaut, Cardell Lars-Olaf, Arebro Julia, Olze Heidi, Förster-Ruhrmann Ulrike, Kowalski Marek L., Olszewska-Ziąber Agnieszka, Holtappels Gabriele, de Ruyck Natalie, Wang Xiangdong, van Drunen Cornelis, Mullol Joaquim, Hellings Peter, Hox Valerie, Toskala Elina, Scadding Glenis, Lund Valerie, Zhang Luo, Fokkens Wytske, Bachert Claus Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers Journal of allergy and clinical immunology 2016;137 (5):1449-1456.e4 [PubMed]
  • van Tongeren Joost Influence of the mucosal environment on the regulation of the local immune response in health and allergic disease 2016. 141p. ISBN 9789461596185. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens W. J.; Co-supervisor: van Drunen C. M.)
  • Golebski Korneliusz, van Tongeren Joost, van Egmond Danielle, de Groot Esther J., Fokkens Wytske J., van Drunen Cornelis M. Specific Induction of TSLP by the Viral RNA Analogue Poly(I:C) in Primary Epithelial Cells Derived from Nasal Polyps PLoS ONE 2016;11 (4):e0152808 [PubMed]

2015

  • Hox V., Maes T., Huvenne W., van Drunen C., Vanoirbeek J. A., Joos G., Bachert C., Fokkens W., Ceuppens J. L., Nemery B., Hellings P. W. A chest physician's guide to mechanisms of sinonasal disease Thorax 2015;70 (4):353-358 [PubMed]
  • Gevorgyan Artur, Segboer Christine, Gorissen Rob, van Drunen Cornelis M., Fokkens Wytske Capsaicin for non-allergic rhinitis Cochrane database of systematic reviews (Online) 2015;2015 (7):CD010591 [PubMed]
  • Shaw Dominick E., Sousa Ana R., Fowler Stephen J., Fleming Louise J., Roberts Graham, Corfield Julie, Pandis Ioannis, Bansal Aruna T., Bel Elisabeth H., Auffray Charles, Compton Chris H., Bisgaard Hans, Bucchioni Enrica, Caruso Massimo, Chanez Pascal, Dahlén Barbro, Dahlen Sven-Erik, Dyson Kerry, Frey Urs, Geiser Thomas, Gerhardsson de Verdier Maria, Gibeon David, Guo Yi-Ke, Hashimoto Simone, Hedlin Gunilla, Jeyasingham Elizabeth, Hekking Pieter-Paul W., Higenbottam Tim, Horváth Ildikó, Knox Alan J., Krug Norbert, Erpenbeck Veit J., Larsson Lars X., Lazarinis Nikos, Matthews John G., Middelveld Roelinde, Montuschi Paolo, Musial Jacek, Myles David, Pahus Laurie, Sandström Thomas, Seibold Wolfgang, Singer Florian, Strandberg Karin, Sterk Peter J., van Aalderen Wim, Lutter Rene, van Drunen Kees, Brinkman Paul, Zwinderman Koos Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort European respiratory journal 2015;46 (5):1308-1321 [PubMed]
  • Golebski Korneliusz, van Egmond Danielle, de Groot Esther J., Roschmann Kristina I. L., Fokkens Wytske J., van Drunen Cornelis M. EGR-1 and DUSP-1 are important negative regulators of pro-allergic responses in airway epithelium Molecular immunology 2015;65 (1):43-50 [PubMed]
  • van Tongeren J., Röschmann K. I. L., Reinartz S. M., Luiten S., Fokkens W. J., de Jong E. C., van Drunen C. M. Expression profiling and functional analysis of Toll-like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response Clinical and translational allergy 2015;5:42 [PubMed]
  • Toppila-Salmi Sanna, van Drunen Cornelis M., Fokkens Wytske J., Golebski Korneliuz, Mattila Pirkko, Joenvaara Sakari, Renkonen Jutta, Renkonen Risto Molecular mechanisms of nasal epithelium in rhinitis and rhinosinusitis Current allergy and asthma reports 2015;15 (2):495 [PubMed]
  • Molenaar Remco J., Botman Dennis, Smits Myrthe A., Hira Vashendriya V., van Lith Sanne A., Stap Jan, Henneman Peter, Khurshed Mohammed, Lenting Krissie, Mul Adri N., Dimitrakopoulou Dionysia, van Drunen Cornelis M., Hoebe Ron A., Radivoyevitch Tomas, Wilmink Johanna W., Maciejewski Jaroslaw P., Vandertop W. Peter, Leenders William P., Bleeker Fonnet E., van Noorden Cornelis J. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198 Cancer research 2015;75 (22):4790-4802 [PubMed]
  • van Tongeren Joost, Golebski Korneliusz, van Egmond Danielle, de Groot Esther J., Fokkens Wytske J., van Drunen Cornelis M. Synergy between TLR-2 and TLR-3 signaling in primary human nasal epithelial cells Immunobiology 2015;220 (4):445-451 [PubMed]
  • Fleming Louise, Murray Clare, Bansal Aruna T., Hashimoto Simone, Bisgaard Hans, Bush Andrew, Frey Urs, Hedlin Gunilla, Singer Florian, van Aalderen Wim M., Vissing Nadja H., Zolkipli Zaraquiza, Selby Anna, Fowler Stephen, Shaw Dominick, Chung Kian Fan, Sousa Ana R., Wagers Scott, Corfield Julie, Pandis Ioannis, Rowe Anthony, Formaggio Elena, Sterk Peter J., Roberts Graham, Tariq Kamran, Dennison Patrick, Behndig Annelie F., Lutter Rene, Wagener Ariane, van Drunen Kees, Hekking Pieter-Paul, Brinkman Paul, Zwinderman Koos, Mores Nadia, Santini Giuseppe, Valente Salvatore, Rossios Christos, Gibeon David, Hoda Uruj, Rocha João Pedro Carvalho da Purificação, Sogbesan Adesimbo, Gent Julaiha, Menzies-Gow Andrew, Campagna Davide, Bigler Jeannette, Boedigheimer Michael J., Yu Wen, Hu Xugang, Fichtner Klaus, Nething Katja The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts European respiratory journal 2015;46 (5):1322-1333 [PubMed]

2014

  • Muller Barbara, van Egmond Danielle, de Groot Esther J. J., Fokkens Wytske J., van Drunen Cornelis M. Characterisation of interleukin-10 expression on different vascular structures in allergic nasal mucosa Clinical and translational allergy 2014;4 (1):2 [PubMed]
  • Reinartz Susanne M. Clinical characterization of allergic sensitization patterns and the role of mucosal dendritic cells 2014. 189p. ISBN 9789462035089. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens W. J.; Co-supervisor: van Drunen C. M.)
  • Wagener Ariane H., Zwinderman Aeilko H., Luiten Silvia, Fokkens Wytske J., Bel Elisabeth H., Sterk Peter J., van Drunen Cornelis M. dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls Respiratory research 2014;15 (1):9 [PubMed]
  • Golebski Korneliusz, Luiten Silvia, van Egmond Danielle, de Groot Esther, Röschmann Kristina Irene Lisolette, Fokkens Wytske Johanna, van Drunen Cornelis Maria High degree of overlap between responses to a virus and to the house dust mite allergen in airway epithelial cells PLoS ONE 2014;9 (2):e87768 [PubMed]
  • Holland Carlijn, van Drunen Cornelis, Denyer Jane, Smart Kevin, Segboer Christine, Terreehorst Ingrid, Newlands Amy, Beerahee Misba, Fokkens Wytske, Tsitoura Daphne C. Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist British journal of clinical pharmacology 2014;77 (5):777-788 [PubMed]
  • Georgalas C., Vlastos I., Picavet V., van Drunen C., Garas G., Prokopakis E. Is chronic rhinosinusitis related to allergic rhinitis in adults and children? Applying epidemiological guidelines for causation Allergy 2014;69 (7):828-833 [PubMed]
  • Muller B., Reinartz S. M., van Egmond D., de Groot E. J. J., Fokkens W. J., van Drunen C. M. Mono-allergic and poly-allergic rhinitis patients have comparable numbers of mucosal Foxp3+CD4+ T lymphocytes Rhinology 2014;52 (3):260-266 [PubMed]
  • Newson R. B., Jones M., Forsberg B., Janson C., Bossios A., Dahlen S.-E., Toskala E. M., Al-Kalemji A., Kowalski M. L., Rymarczyk B., Salagean E. M., van Drunen C. M., Bachert C., Wehrend T., Krämer U., Mota-Pinto A., Burney P., Leynaert B., Jarvis D. The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin Clinical and experimental allergy 2014;44 (2):250-260 [PubMed]

2013

  • Gevorgyan Artur, Segboer Christine, Gorissen Rob, van Drunen Cornelis M., Fokkens Wytske Capsaicin for non-allergic rhinitis Cochrane database of systematic reviews (Online) 2013;2013 (6)
  • Liu Quan, Liu Juan, Roschmann Kristina Irene Lisolette, van Egmond Danielle, Golebski Korneliusz, Fokkens Wytske Johanna, Wang Dehui, van Drunen Cornelis Maria Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells Journal of inflammation (London, England) 2013;10 (1):15 [PubMed]
  • van Drunen C., Fokkens Wystske Immunology and the Nose: From Basic Science to Clinicalin: C. Georgalas, W. J. Fokkens, editors. Rhinology and Skull Base Surgery. From the Lab to the Operating Room: An Evidence-based Approach. Stuttgart: Thieme; 2013. p. 62, ISBN 9783131535412
  • van Drunen Cornelis M., Fokkens Wytske Immunology and the Nose: From Basic Science to Clinical (Ch. 4)in: C. Georgalas, W. J. Fokkens, editors. Rhinology and Skull Base Surgery. From the Lab to the Operating Room: An Evidence-based Approach. Stuttgart: Thieme; 2013. p. 62-76, ISBN 9783131535412
  • Segboer C. L., Holland C. T., Reinartz S. M., Terreehorst I., Gevorgyan A., Hellings P. W., van Drunen C. M., Fokkens W. J. Nasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis Allergy 2013;68 (11):1427-1434 [PubMed]
  • Tomassen P., Jarvis D., Newson R., van Ree R., Forsberg B., Howarth P., Janson C., Kowalski M. L., Krämer U., Matricardi P. M., Middelveld R. J. M., Todo-Bom A., Toskala E., Thilsing T., Brożek G., van Drunen C., Burney P., Bachert C. Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2)LEN study Allergy 2013;68 (10):1289-1297 [PubMed]
  • Wagener Ariane H., Zwinderman Aeilko H., Luiten Silvia, Fokkens Wytske J., Bel Elisabeth H., Sterk Peter J., van Drunen Cornelis M. The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression PLoS ONE 2013;8 (11):e80257 [PubMed]
  • Golebski K., Röschmann K. I. L., Toppila-Salmi S., Hammad H., Lambrecht B. N., Renkonen R., Fokkens W. J., van Drunen C. M. The multi-faceted role of allergen exposure to the local airway mucosa Allergy 2013;68 (2):152-160 [PubMed]

2012

  • Röschmann K. I. L., van Kuijen A.-M., Luiten S., Jonker M. J., Breit T. M., Fokkens W. J., Petersen A., van Drunen C. M. Comparison of Timothy grass pollen extract- and single major allergen-induced gene expression and mediator release in airway epithelial cells: a meta-analysis Clinical and experimental allergy 2012;42 (10):1479-1490 [PubMed]
  • Hellings P. W., Scadding G., Alobid I., Bachert C., Fokkens W. J., Gerth van Wijk R., Gevaerts P., Guilemany J., Kalogjera L., Lund V. J., Mullol J., Passalacqua G., Toskala E., van Drunen C. M. Executive summary of European Task Force document on diagnostic tools in rhinology Rhinology 2012;50 (4):339-352 [PubMed]
  • Fokkens Wytske J., Rinia Bas, van Drunen Cornelis M., Hellings Peter W., Hens Greet, Jansen Ad, Blom Henk, Wu Wei, Clements Diane S., Lee Laurie A., Philpot Edward E. No mucosal atrophy and reduced inflammatory cells: Active-controlled trial with yearlong fluticasone furoate nasal spray American journal of rhinology & allergy 2012;26 (1):36-44 [PubMed]
  • Röschmann K. I. L., van Kuijen A.-M., Luiten S., Jonker M. J., Breit T. M., Fokkens W. J., Petersen A., van Drunen C. M. Purified Timothy grass pollen major allergen Phl p 1 may contribute to the modulation of allergic responses through a pleiotropic induction of cytokines and chemokines from airway epithelial cells Clinical and experimental immunology 2012;167 (3):413-421 [PubMed]
  • Fokkens Wytske J., van Drunen Cornelis, Georgalas Christos, Ebbens Fenna Role of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejected Current opinion in otolaryngology & head and neck surgery 2012;20 (1):19-23 [PubMed]
  • van Drunen Cornelis M., Mjösberg Jenny M., Segboer Christine L., Cornet Marjolein E., Fokkens Wytske J. Role of Innate Immunity in the Pathogenesis of Chronic Rhinosinusitis: Progress and New Avenues Current allergy and asthma reports 2012;12 (2):120-126 [PubMed]
  • Mjösberg Jenny, Bernink Jochem, Golebski Korneliusz, Karrich Julien J., Peters Charlotte P., Blom Bianca, te Velde Anje A., Fokkens Wytske J., van Drunen Cornelis M., Spits Hergen The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells Immunity 2012;37 (4):649-659 [PubMed]

2011

  • Hastan D., Fokkens W. J., Bachert C., Newson R. B., Bislimovska J., Bockelbrink A., Bousquet P. J., Brozek G., Bruno A., Dahlén S. E., Forsberg B., Gunnbjörnsdóttir M., Kasper L., Krämer U., Kowalski M. L., Lange B., Lundbäck B., Salagean E., Todo-Bom A., Tomassen P., Toskala E., van Drunen C. M., Bousquet J., Zuberbier T., Jarvis D., Burney P. Chronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study Allergy 2011;66 (9):1216-1223 [PubMed]
  • Reinartz Susanne M., van Tongeren Joost, van Egmond Danielle, de Groot Esther J. J., Fokkens Wytske J., van Drunen Cornelis M. Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Journal of allergy and clinical immunology 2011;128 (4):887-890 [PubMed]
  • Scadding Glenis, Hellings Peter, Alobid Isam, Bachert Claus, Fokkens Wytske, Van Wijk Roy Gerth, Gevaert Philippe, Guilemany Josep, Kalogjera Livije, Lund Valerie, Mullol Joaquim, Passalacqua Giovanni, Toskala Elina, Van Drunen Cornelius Diagnostic tools in Rhinology EAACI position paper Clinical and translational allergy 2011;1 (1):1-39
  • Mjösberg Jenny M., Trifari Sara, Crellin Natasha K., Peters Charlotte P., van Drunen Cornelis M., Piet Berber, Fokkens Wytske J., Cupedo Tom, Spits Hergen Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 Nature immunology 2011;12 (11):1055-1062 [PubMed]
  • Videler W. J. M., Georgalas C., Menger D. J., Freling N. J. M., van Drunen C. M., Fokkens W. J. Osteitic bone in recalcitrant chronic rhinosinusitis Rhinology 2011;49 (2):139-147 [PubMed]
  • Ebbens F. A., Toppila-Salmi S., de Groot E. J. J., Renkonen J., Renkonen R., van Drunen C. M., Dijkgraaf M. G. W., Fokkens W. J. Predictors of post-operative response to treatment: a double blind placebo controlled study in chronic rhinosinusitis patients Rhinology 2011;49 (4):413-419 [PubMed]
  • Röschmann K. I. L., Luiten S., Jonker M. J., Breit T. M., Fokkens W. J., Petersen A., van Drunen C. M. Timothy grass pollen extract-induced gene expression and signalling pathways in airway epithelial cells Clinical and experimental allergy 2011;41 (6):830-841 [PubMed]
  • Papadopoulos N. G., Christodoulou I., Rohde G., Agache I., Almqvist C., Bruno A., Bonini S., Bont L., Bossios A., Bousquet J., Braido F., Brusselle G., Canonica G. W., Carlsen K. H., Chanez P., Fokkens W. J., Garcia-Garcia M., Gjomarkaj M., Haahtela T., Holgate S. T., Johnston S. L., Konstantinou G., Kowalski M., Lewandowska-Polak A., Lødrup-Carlsen K., Mäkelä M., Malkusova I., Mullol J., Nieto A., Eller E., Ozdemir C., Panzner P., Popov T., Psarras S., Roumpedaki E., Rukhadze M., Stipic-Markovic A., Todo Bom A., Toskala E., van Cauwenberge P., van Drunen C., Watelet J. B., Xatzipsalti M., Xepapadaki P., Zuberbier T. Viruses and bacteria in acute asthma exacerbations--a GA² LEN-DARE systematic review Allergy 2011;66 (4):458-468 [PubMed]

2010

  • Bobic Sonja, van Drunen C. M., Callebaut I., Hox V., Jorissen M., Fokkens W. J., Hellings P. W. Dexamethasone-induced apoptosis of freshly isolated human nasal epithelial cells concomitant with abrogation of IL-8 production Rhinology 2010;48 (4):401-407 [PubMed]
  • Ebbens F. A., Toppila-Salmi S. K., Renkonen J. A., Renkonen R. L. O., Mullol J., van Drunen C. M., Fokkens W. J. Endothelial L-selectin ligand expression in nasal polyps Allergy 2010;65 (1):95-102 [PubMed]
  • van Pottelberge G. R., Bracke K. R., van den Broeck S., Reinartz S. M., van Drunen C. M., Wouters E. F., Verleden G. M., Vermassen F. E., Joos G. F., Brusselle G. G. Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD European respiratory journal 2010;36 (4):781-791 [PubMed]
  • van Pottelberge Geert R., Bracke Ken R., Demedts Ingel K., de Rijck Kim, Reinartz Susanne M., van Drunen Cornelis M., Verleden Geert M., Vermassen Frank E., Joos Guy F., Brusselle Guy G. Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD Respiratory research 2010;11 (1):35 [PubMed]

2009

  • Spyridaki Irini S., Christodoulou Ioannis, de Beer Lieke, Hovland Vegard, Kurowski Marcin, Olszewska-Ziaber Agnieszka, Carlsen Kai-Håkon, Lødrup-Carlsen Karin, van Drunen Cornelis M., Kowalski Marek L., Molenkamp Richard, Papadopoulos Nikolaos G. Comparison of four nasal sampling methods for the detection of viral pathogens by RT-PCR-A GA(2)LEN project Journal of virological methods 2009;156 (1-2):102-106 [PubMed]
  • Ebbens Fenna A. Controversies in chronic rhinosinusitis 2009. 216p. ISBN 9789064643316. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens W. J.; Co-supervisor: van Drunen C. M.)
  • Reinartz Susanne M., van Ree Ronald, Versteeg Serge A., Zuidmeer Laurian, van Drunen Cornelis M., Fokkens Wytske J. Diminished response to grass pollen allergen challenge in subjects with concurrent house dust mite allergy Rhinology 2009;47 (2):192-198 [PubMed]
  • Fokkens Wytske J., Ebbens Fenna, van Drunen Cornelis M. Fungus: A Role in Pathophysiology of Chronic Rhinosinusitis, Disease Modifier, A Treatment Target, or No Role at All? Immunology and allergy clinics of North America 2009;29 (4):677-+ [PubMed]
  • Bachert C., van Bruaene N., Toskala E., Zhang N., Olze H., Scadding G., van Drunen C. M., Mullol J., Cardell L., Gevaert P., van Zele T., Claeys S., Halldén C., Kostamo K., Foerster U., Kowalski M., Bieniek K., Olszewska-Ziaber A., Nizankowska-Mogilnicka E., Szczeklik A., Swierczynska M., Arcimowicz M., Lund V., Fokkens W., Zuberbier T., Akdis C., Canonica G., van Cauwenberge P., Burney P., Bousquet J. Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GALEN study Allergy 2009;64 (4):520-533 [PubMed]
  • van Drunen Cornelis M., Reinartz Susanne, Wigman Jochem, Fokkens Wytske J. Inflammation in Chronic Rhinosinusitis and Nasal Polyposis Immunology and allergy clinics of North America 2009;29 (4):621-+ [PubMed]
  • Muller B., de Groot E. J. J., Kortekaas I. J. M., Fokkens W. J., van Drunen C. M. Nasal endothelial interleukin-10 expression is negatively correlated with nasal symptoms after allergen provocation Allergy 2009;64 (5):738-745 [PubMed]
  • Vroling Aram B. Nasal epithelial cells: effector cells in allergy 2009. 179p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Fokkens W. J.; Co-supervisor: van Drunen C. M.)
  • Ebbens Fenna A., Georgalas Christos, Luiten Silvia, van Drunen Cornelis M., Badia Lydia, Scadding Glenis K., Hellings Peter W., Jorissen Mark, Mullol Joaquim, Cardesin Alda, Bachert Claus, van Zele Thibaut P. J., Lund Valerie J., Fokkens W. J. The Effect of Topical Amphotericin B on Inflammatory Markers in Patients With Chronic Rhinosinusitis: A Multicenter Randomized Controlled Study Laryngoscope 2009;119 (2):401-408 [PubMed]
  • Ebbens F. A., Maldonado M., de Groot E. J. J., Alobid I., van Drunen C. M., Picado C., Fokkens W. J., Mullol J. Topical glucocorticoids downregulate COX-1 positive cells in nasal polyps Allergy 2009;64 (1):96-103 [PubMed]

2008

  • Vroling A. B., Jonker M. J., Breit T. M., Fokkens W. J., van Drunen C. M. Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway Allergy 2008;63 (4):461-467 [PubMed]
  • van Drunen C. M., Vroling A. B., Rinia A. B., Fokkens W. J. Considerations on the application of microarray analysis in rhinology Rhinology 2008;46 (4):259-266 [PubMed]
  • Verstege Marleen I., ten Kate Fiebo J. W., Reinartz Susanne M., van Drunen Cornelis M., Slors Frederik J. M., Bemelman Willem A., Vyth-Dreese Florry A., te Velde Anje A. Dendritic cell populations in colon and mesenteric lymph nodes of patients with Crohn's disease journal of histochemistry and cytochemistry 2008;56 (3):233-241 [PubMed]
  • Vroling A. B., Fokkens W. J., van Drunen C. M. How epithelial cells detect danger: aiding the immune response Allergy 2008;63 (9):1110-1123 [PubMed]
  • Eijgenraam Jan-Willem, Reinartz Susanne M., Kamerling Sylvia W. A., van Ham Vanessa J., Zuidwijk Kim, van Drunen Cornelis M., Daha Mohamed R., Fokkens Wytske J., van Kooten Cees Immuno-histological analysis of dendritic cells in nasal biopsies of IgA nephropathy patients Nephrology, dialysis, transplantation 2008;23 (2):612-620 [PubMed]
  • van Tongeren J., Reinartz S. M., Fokkens W. J., de Jong E. C., van Drunen C. M. Interactions between epithelial cells and dendritic cells in airway immune responses: lessons from allergic airway disease Allergy 2008;63 (9):1124-1135 [PubMed]
  • Videler W. J. M., van Drunen C. M., Reitsma J. B., Fokkens W. J. Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study Rhinology 2008;46 (2):92-98 [PubMed]
  • Vroling Aram B., Jonker Martijs J., Luiten Silvia, Breit Timo M., Fokkens Wytske J., van Drunen Cornelis M. Primary nasal epithelium exposed to house dust mite extract shows activated expression in allergic individuals American journal of respiratory cell and molecular biology 2008;38 (3):293-299 [PubMed]

2007

  • Vroling A. B., Duinsbergen D., Fokkens W. J., van Drunen C. M. Allergen induced gene expression of airway epithelial cells shows a possible role for TNF-alpha Allergy 2007;62 (11):1310-1319 [PubMed]
  • Papadopoulos N. G., Xepapadaki P., Mallia P., Brusselle G., Watelet J.-B., Xatzipsalti M., Foteinos G., van Drunen C. M., Fokkens W. J., D'Ambrosio C., Bonini S., Bossios A., Lotvall Jan, van Cauwenberge P., Holgate S. T., Canonica G. W., Szczeklik A., Rohde G., Kimpen J., Pitkaranta A., Makela M., Chanez P., Ring J., Johnston S. L. Mechanisms of virus-induced asthma exacerbations: state-of-the-art. A GA2LEN and InterAirways document Allergy 2007;62 (5):457-470 [PubMed]
  • Muller B., de Groot E. J. J., Kortekaas I. J. M., Fokkens W. J., van Drunen C. M. Nasal epithelial cells express IL-10 at levels that negatively correlate with clinical symptoms in patients with house dust mite allergy Allergy 2007;62 (9):1014-1022 [PubMed]
  • Rinia A. B., Kostamo K., Ebbens F. A., van Drunen C. M., Fokkens W. J. Nasal polyposis: a cellular-based approach to answering questions Allergy 2007;62 (4):348-358 [PubMed]
  • Videler Ward J. M., van Drunen Cornelis M., van der Meulen Freerk W., Fokkens Wytske J. Radical surgery: effect on quality of life and pain in chronic rhinosinusitis Otolaryngology-head and neck surgery 2007;136 (2):261-267 [PubMed]
  • Ebbens F. A., Georgalas C., Rinia A. B., van Drunen C. M., Lund V. J., Fokkens W. J. The fungal debate: where do we stand today? Rhinology 2007;45 (3):178-189 [PubMed]

2006

  • van Drunen C. M., Fokkens W. J. Basophils and mast cells at the centre of the immunological response Allergy 2006;61 (3):273-275 [PubMed]
  • Fokkens W., van Drunen C. M. Nose and lung, two of a kind? Allergy 2006;61 (6):653-655 [PubMed]

2005

  • van Benten I. J., van Drunen C. M., Koopman L. P., van Middelkoop B. C., Hop W. C. J., Osterhaus A. D. M. E., Neijens H. J., Fokkens W. J. Age- and infection-related maturation of the nasal immune response in 0-2-year-old children Allergy 2005;60 (2):226-232 [PubMed]
  • Van Drunen Cornelis, Meltzer Eli O., Bachert Claus, Bousquet Jean, Fokkens Wytske J. Allergy: Foreword Allergy: European Journal of Allergy and Clinical Immunology, Supplement 2005;60 (80):3
  • Reinartz S. M., Overbeek S. E., Kleinjan A., van Drunen C. M., Braunstahl G.-J., Hoogsteden H. C., Fokkens W. J. Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients Allergy 2005;60 (10):1301-1307 [PubMed]
  • Oldenbeuving N. B., Kleinjan A., Mulder P. G., Lumley P., de Groot E. J. J., van Drunen C. M., Fokkens W. J. Evaluation of an intranasal house dust mite provocation model as a tool in clinical research Allergy 2005;60 (6):751-759 [PubMed]
  • van Drunen C., Meltzer E. O., Bachert C., Bousquet J., Fokkens W. J. Nasal allergies and beyond: a clinical review of the pharmacology, efficacy, and safety of mometasone furoate Allergy 2005;60 (Suppl. 80):5-19 [PubMed]
  • van Drunen C. M., Meltzer E. O., Bachert C., Bousquet J., Fokkens W. J. Nasal allergies and beyond: a clinical review of the pharmacology, efficacy, and safety, of mometasone furoate - Foreword Allergy 2005;60 (Suppl. 80):3
  • van Benten I. J., van Drunen C. M., Koevoet J. L. M., Koopman L. P., Hop W. C. J., Osterhaus A. D. M. E., Neijens H. J., Fokkens W. J. Reduced nasal IL-10 and enhanced TNFalpha responses during rhinovirus and RSV-induced upper respiratory tract infection in atopic and non-atopic infants Journal of medical virology 2005;75 (2):348-357 [PubMed]

2004

  • van Benten I. J., van Drunen C. M., Neijens H. J., Fokkens W. J. Virale respiratoire infecties en de ontwikkeling van de immuunrespons in de neus van jonge kinderen: de VIGALL-studie: proefschriftbespreking Nederlands tijdschrift voor allergie 2004 (3):114-118

2003

  • van Benten Inesz, Koopman Laurens, Niesters Bert, Hop Wim, van Middelkoop Barbara, de Waal Leon, van Drunen Kees, Osterhaus Albert, Neijens Herman, Fokkens Wytske Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants Pediatric allergy and immunology 2003;14 (5):363-370 [PubMed]
  • van Benten Inesz J., van Drunen Cornelis M., Koopman Laurens P., Kleinjan Alex, van Middelkoop Barbara C., de Waal Leon, Osterhaus Albert D. M. E., Neijens Herman J., Fokkens Wytske J. RSV-induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL-18 response Journal of medical virology 2003;71 (2):290-297 [PubMed]

2001

  • Barlow A. L., van Drunen C. M., Johnson C. A., Tweedie S., Bird A., Turner B. M. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster Experimental cell research 2001;265 (1):90-103 [PubMed]

2000

  • Fransz P. F., Armstrong S., de Jong J. H., Parnell L. D., van Drunen C., Dean C., Zabel P., Bisseling T., Jones G. H. Integrated cytogenetic map of chromosome arm 4S of A. thaliana: structural organization of heterochromatic knob and centromere region Cell 2000;100 (3):367-376 [PubMed]
  • Kipp M., Göhring F., Ostendorp T., van Drunen C. M., van Driel R., Przybylski M., Fackelmayer F. O. SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA Molecular and cellular biology 2000;20 (20):7480-7489 [PubMed]

1999

  • van Drunen C. M., Sewalt R. G., Oosterling R. W., Weisbeek P. J., Smeekens S. C., van Driel R. A bipartite sequence element associated with matrix/scaffold attachment regions Nucleic acids research 1999;27 (14):2924-2930 [PubMed]

1998

  • Fischer D. F., van Drunen C. M., Winkler G. S., van de Putte P., Backendorf C. Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker Nucleic acids research 1998;26 (23):5288-5294 [PubMed]

1997

  • van Drunen C. M., Oosterling R. W., Keultjes G. M., Weisbeek P. J., van Driel R., Smeekens S. C. Analysis of the chromatin domain organisation around the plastocyanin gene reveals an MAR-specific sequence element in Arabidopsis thaliana Nucleic acids research 1997;25 (19):3904-3911 [PubMed]

1994

  • van Drunen C. M., Mientjes E., van Zuylen O., van de Putte P., Goosen N. Transposase A binding sites in the attachment sites of bacteriophage Mu that are essential for the activity of the enhancer and A binding sites that promote transposition towards Fpro-lac Nucleic acids research 1994;22 (5):773-779 [PubMed]

1992

  • Nilsson L., Verbeek H., Vijgenboom E., van Drunen C., Vanet A., Bosch L. FIS-dependent trans activation of stable RNA operons of Escherichia coli under various growth conditions Journal of bacteriology 1992;174 (3):921-929 [PubMed]

1986

  • van der Lubbe J. L., Abrahams P. J., van Drunen C. M., van der Eb A. J. Enhanced induction of SV40 replication from transformed rat cells by fusion with UV-irradiated normal and repair-deficient human fibroblasts Mutation research 1986;165 (2):47-56 [PubMed]

1985

  • van der Lubbe J. L., van Drunen C. M., Hertoghs J. J., Cornelis J. J., Rommelaere J., van der Eb A. J. Enhanced induction of SV40 replication from transformed mammalian cells by fusion with UV-irradiated untransformed cells Mutation research 1985;151 (1):1-8 [PubMed]
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