E. van der Pol MEng PhD publications

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Publications MEng PhD E. van der Pol

Positions
Assistant Professor, Research Associate
Main activities
Research
Specialisation
Detection of cell-derived extracellular vesicles (e.g. exosomes, microvesicles) as biomarkers for disease
Focus of research

Background. Clinical decisions for diagnosis, prognosis, and therapy are often based on information from biochemical and cellular analysis of blood and urine. It is becoming increasingly clear that these body fluids also contain numerous small (<0.001 mm) extracellular vesicles, often referred to as exosomes or microvesicles. Vesicles originate from a variety of cells and functions of vesicles include intercellular communication, coagulation, and inflammation. The vesicle profile (size, concentration, biochemical composition, and cellular origin) and function are altered in e.g. cancer and cardiovascular disease. Accordingly, the ability to measure this vesicle profile strongly adds to understanding the development of major diseases and provides a way for early detection of these diseases.

Problem. Although the clinical relevance of vesicles is increasingly recognized, the detection of exosomes, microparticles, and other extracellular vesicles is very challenging. Due to their small size and low refractive index vesicles are below the detection range of modern techniques. Consequently, worldwide no device is available that can determine the vesicle profile directly in body fluids to obtain clinical information.

Goals. The goals of my research is to standardize vesicle measurements and to develop a device that is suitable for clinical use and capable of accurately measuring the size, morphology (shape and ultrastructure), biochemical composition (proteins, lipids, RNA, DNA), and cellular origin of single vesicles at a rate of thousands per second.

For more information and a complete list of peer-reviewed articles to which I contributed, please visit www.edwinvanderpol.com.

2020

  • de Rond Leonie, van der Pol Edwin, Bloemen Paul R., van den Broeck Tina, Monheim Ludo, Nieuwland Rienk, van Leeuwen Ton G., Coumans Frank A. W. A Systematic Approach to Improve Scatter Sensitivity of a Flow Cytometer for Detection of Extracellular Vesicles Cytometry. Part A 2020;97 (6):582-591 [PubMed]
  • Rikkert L. G., Beekman P., Caro J., Coumans F. A. W., Enciso-Martinez A., Jenster G., le Gac S., Lee W., van Leeuwen T. G., Loozen G. B., Nanou A., Nieuwland R., Offerhaus H. L., Otto C., Pegtel D. M., Piontek M. C., van der Pol E., de Rond L., Roos W. H., Schasfoort R. B. M., Wauben M. H. M., Zuilhof H., Terstappen L. W. M. M. Cancer-id: Toward identification of cancer by tumor-derived extracellular vesicles in blood Frontiers in oncology 2020;10 [PubMed]
  • Enciso-Martinez Agustin, van der Pol Edwin, Hau Chi M., Nieuwland Rienk, van Leeuwen Ton G., Terstappen Leon W. M. M., Otto Cees Label-free identification and chemical characterisation of single extracellular vesicles and lipoproteins by synchronous Rayleigh and Raman scattering Journal of extracellular vesicles 2020;9 (1) [PubMed]
  • Welsh Joshua A., van der Pol Edwin, Arkesteijn Ger J. A., Bremer Michel, Brisson Alain, Coumans Frank, Dignat-George Françoise, Duggan Erika, Ghiran Ionita, Giebel Bernd, Görgens André, Hendrix An, Lacroix Romaric, Lannigan Joanne, Libregts Sten F. W. M., Lozano-Andrés Estefanía, Morales-Kastresana Aizea, Robert Stephane, de Rond Leonie, Tertel Tobias, Tigges John, de Wever Olivier, Yan Xiaomei, Nieuwland Rienk, Wauben Marca H. M., Nolan John P., Jones Jennifer C. MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments Journal of extracellular vesicles 2020;9 (1) [PubMed]
  • Welsh Joshua A., Tang Vera A., van der Pol Edwin, Görgens André MIFlowCyt-EV: The Next Chapter in the Reporting and Reliability of Single Extracellular Vesicle Flow Cytometry Experiments Cytometry. Part A 2020 [PubMed]
  • de Rond Leonie, Coumans Frank A. W., Welsh Joshua A., Nieuwland Rienk, van Leeuwen Ton G., van der Pol Edwin Quantification of Light Scattering Detection Efficiency and Background in Flow Cytometry Cytometry. Part A 2020 [PubMed]
  • Gasecka Aleksandra, Nieuwland Rienk, Budnik Monika, Dignat-George Françoise, Eyileten Ceren, Harrison Paul, Huczek Zenon, Kapłon-Cieślicka Agnieszka, Lacroix Romaric, Opolski Grzegorz, Pluta Kinga, van der Pol Edwin, Postuła Marek, Leroyer Aurélie, Siljander Pia, Sturk Auguste, Filipiak Krzysztof J. Randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles (AFFECT EV) in acute myocardial infarction Platelets 2020;31 (1):26-32 [PubMed]
  • Kuiper Martine, van de Nes Arthur, Nieuwland Rienk, Varga Zoltan, van der Pol Edwin Reliable measurements of extracellular vesicles by clinical flow cytometry American journal of reproductive immunology (New York, N.Y. 2020 [PubMed]
  • Enciso-Martinez Agustin, van der Pol Edwin, Lenferink Aufried T. M., Terstappen Leon W. M. M., van Leeuwen Ton G., Otto Cees Synchronized Rayleigh and Raman scattering for the characterization of single optically trapped extracellular vesicles Nanomedicine: nanotechnology, biology and medicine 2020;24 [PubMed]
  • Welsh Joshua A., van der Pol Edwin, Bettin Britta A., Carter David R. F., Hendrix An, Lenassi Metka, Langlois Marc-André, Llorente Alicia, van de Nes Arthur S., Nieuwland Rienk, Tang Vera, Wang Lili, Witwer Kenneth W., Jones Jennifer C. Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration Journal of extracellular vesicles 2020;9 (1) [PubMed]

2019

  • Cossarizza Andrea, Chang Hyun-Dong, Radbruch Andreas, Acs Andreas, Adam Dieter, Adam-Klages Sabine, Agace William W., Aghaeepour Nima, Akdis M. beccel, Allez Matthieu, Almeida Larissa Nogueira, Alvisi Giorgia, Anderson Graham, Andrä Immanuel, Annunziato Francesco, Anselmo Achille, Bacher Petra, Baldari Cosima T., Bari Sudipto, Barnaba Vincenzo, Barros-Martins Joana, Battistini Luca, Bauer Wolfgang, Baumgart Sabine, Baumgarth Nicole, Baumjohann Dirk, Baying Bianka, Bebawy Mary, Becher Burkhard, Beisker Wolfgang, Benes Vladimir, Beyaert Rudi, Blanco Alfonso, Boardman Dominic A., Bogdan Christian, Borger Jessica G., Borsellino Giovanna, Boulais Philip E., Bradford Jolene A., Brenner Dirk, Brinkman Ryan R., Brooks Anna E. S., Busch Dirk H., Büscher Martin, Bushnell Timothy P., Calzetti Federica, Cameron Garth, Cammarata Ilenia, Cao Xuetao, Cardell Susanna L., Casola Stefano, Cassatella Marco A., Cavani Andrea, Celada Antonio, Chatenoud Lucienne, Chattopadhyay Pratip K., Chow Sue, Christakou Eleni, Čičin-Šain Luka, Clerici Mario, Colombo Federico S., Cook Laura, Cooke Anne, Cooper Andrea M., Corbett Alexandra J., Cosma Antonio, Cosmi Lorenzo, Coulie Pierre G., Cumano Ana, Cvetkovic Ljiljana, Dang Van Duc, Dang-Heine Chantip, Davey Martin S., Davies Derek, de Biasi Sara, del Zotto Genny, Dela Cruz Gelo Victoriano, Delacher Michael, Della Bella Silvia, Dellabona Paolo, Deniz G. nnur, Dessing Mark, di Santo James P., Diefenbach Andreas, Dieli Francesco, Dolf Andreas, Dörner Thomas, Dress Regine J., Dudziak Diana, Dustin Michael, Dutertre Charles-Antoine, Ebner Friederike, Eckle Sidonia B. G., Edinger Matthias, Eede Pascale, Ehrhardt G. tz R. A., Eich Marcus, Engel Pablo, Engelhardt Britta, Erdei Anna, Esser Charlotte, Everts Bart, Evrard Maximilien, Falk Christine S., Fehniger Todd A., Felipo-Benavent Mar, Ferry Helen, Feuerer Markus, Filby Andrew, Filkor Kata, Fillatreau Simon, Follo Marie, Förster Irmgard, Foster John, Foulds Gemma A., Frehse Britta, Frenette Paul S., Frischbutter Stefan, Fritzsche Wolfgang, Galbraith David W., Gangaev Anastasia, Garbi Natalio, Gaudilliere Brice, Gazzinelli Ricardo T., Geginat Jens, Gerner Wilhelm, Gherardin Nicholas A., Ghoreschi Kamran, Gibellini Lara, Ginhoux Florent, Goda Keisuke, Godfrey Dale I., Goettlinger Christoph, González-Navajas Jose M., Goodyear Carl S., Gori Andrea, Grogan Jane L., Grummitt Daryl, Grützkau Andreas, Haftmann Claudia, Hahn Jonas, Hammad Hamida, Hämmerling G. nter, Hansmann Leo, Hansson Goran, Harpur Christopher M., Hartmann Susanne, Hauser Andrea, Hauser Anja E., Haviland David L., Hedley David, Hernández Daniela C., Herrera Guadalupe, Herrmann Martin, Hess Christoph, Höfer Thomas, Hoffmann Petra, Hogquist Kristin, Holland Tristan, Höllt Thomas, Holmdahl Rikard, Hombrink Pleun, Houston Jessica P., Hoyer Bimba F., Huang Bo, Huang Fang-Ping, Huber Johanna E., Huehn Jochen, Hundemer Michael, Hunter Christopher A., Hwang William Y. K., Iannone Anna, Ingelfinger Florian, Ivison Sabine M., Jäck Hans-Martin, Jani Peter K., Jávega Beatriz, Jonjic Stipan, Kaiser Toralf, Kalina Tomas, Kamradt Thomas, Kaufmann Stefan H. E., Keller Baerbel, Ketelaars Steven L. C., Khalilnezhad Ahad, Khan Srijit, Kisielow Jan, Klenerman Paul, Knopf Jasmin, Koay Hui-Fern, Kobow Katja, Kolls Jay K., Kong Wan Ting, Kopf Manfred, Korn Thomas, Kriegsmann Katharina, Kristyanto Hendy, Kroneis Thomas, Krueger Andreas, Kühne Jenny, Kukat Christian, Kunkel D. sirée, Kunze-Schumacher Heike, Kurosaki Tomohiro, Kurts Christian, Kvistborg Pia, Kwok Immanuel, Landry Jonathan, Lantz Olivier, Lanuti Paola, LaRosa Francesca, Lehuen Agnès, LeibundGut-Landmann Salomé, Leipold Michael D., Leung Leslie Y. T., Levings Megan K., Lino Andreia C., Liotta Francesco, Litwin Virginia, Liu Yanling, Ljunggren Hans-Gustaf, Lohoff Michael, Lombardi Giovanna, Lopez Lilly, López-Botet Miguel, Lovett-Racke Amy E., Lubberts Erik, Luche Herve, Ludewig Burkhard, Lugli Enrico, Lunemann Sebastian, Maecker Holden T., Maggi Laura, Maguire Orla, Mair Florian, Mair Kerstin H., Mantovani Alberto, Manz Rudolf A., Marshall Aaron J., Martínez-Romero Alicia, Martrus Glòria, Marventano Ivana, Maslinski Wlodzimierz, Matarese Giuseppe, Mattioli Anna Vittoria, Maueröder Christian, Mazzoni Alessio, McCluskey James, McGrath Mairi, McGuire Helen M., McInnes Iain B., Mei Henrik E., Melchers Fritz, Melzer Susanne, Mielenz Dirk, Miller Stephen D., Mills Kingston H. G., Minderman Hans, Mjösberg Jenny, Moore Jonni, Moran Barry, Moretta Lorenzo, Mosmann Tim R., Müller Susann, Multhoff Gabriele, Muñoz Luis Enrique, Münz Christian, Nakayama Toshinori, Nasi Milena, Neumann Katrin, Ng Lai Guan, Niedobitek Antonia, Nourshargh Sussan, Núñez Gabriel, O'Connor José-Enrique, Ochel Aaron, Oja Anna, Ordonez Diana, Orfao Alberto, Orlowski-Oliver Eva, Ouyang Wenjun, Oxenius Annette, Palankar Raghavendra, Panse Isabel, Pattanapanyasat Kovit, Paulsen Malte, Pavlinic Dinko, Penter Livius, Peterson P. rt, Peth Christian, Petriz Jordi, Piancone Federica, Pickl Winfried F., Piconese Silvia, Pinti Marcello, Pockley A. Graham, Podolska Malgorzata Justyna, Poon Zhiyong, Pracht Katharina, Prinz Immo, Pucillo Carlo E. M., Quataert Sally A., Quatrini Linda, Quinn Kylie M., Radbruch Helena, Radstake Tim R. D. J., Rahmig Susann, Rahn Hans-Peter, Rajwa Bartek, Ravichandran Gevitha, Raz Yotam, Rebhahn Jonathan A., Recktenwald Diether, Reimer Dorothea, Reis e Sousa Caetano, Remmerswaal Ester B. M., Richter Lisa, Rico Laura G., Riddell Andy, Rieger Aja M., Robinson J. Paul, Romagnani Chiara, Rubartelli Anna, Ruland J. rgen, Saalmüller Armin, Saeys Yvan, Saito Takashi, Sakaguchi Shimon, Sala-de-Oyanguren Francisco, Samstag Yvonne, Sanderson Sharon, Sandrock Inga, Santoni Angela, Sanz Ramon Bellmàs, Saresella Marina, Sautes-Fridman Catherine, Sawitzki Birgit, Schadt Linda, Scheffold Alexander, Scherer Hans U., Schiemann Matthias, Schildberg Frank A., Schimisky Esther, Schlitzer Andreas, Schlosser Josephine, Schmid Stephan, Schmitt Steffen, Schober Kilian, Schraivogel Daniel, Schuh Wolfgang, Schüler Thomas, Schulte Reiner, Schulz Axel Ronald, Schulz Sebastian R., Scottá Cristiano, Scott-Algara Daniel, Sester David P., Shankey T. Vincent, Silva-Santos Bruno, Simon Anna Katharina, Sitnik Katarzyna M., Sozzani Silvano, Speiser Daniel E., Spidlen Josef, Stahlberg Anders, Stall Alan M., Stanley Natalie, Stark Regina, Stehle Christina, Steinmetz Tobit, Stockinger Hannes, Takahama Yousuke, Takeda Kiyoshi, Tan Leonard, Tárnok Attila, Tiegs Gisa, Toldi Gergely, Tornack Julia, Traggiai Elisabetta, Trebak Mohamed, Tree Timothy I. M., Trotter Joe, Trowsdale John, Tsoumakidou Maria, Ulrich Henning, Urbanczyk Sophia, van de Veen Willem, van den Broek Maries, van der Pol Edwin, van Gassen Sofie, van Isterdael Gert, van Lier René A. W., Veldhoen Marc, Vento-Asturias Salvador, Vieira Paulo, Voehringer David, Volk Hans-Dieter, von Borstel Anouk, von Volkmann Konrad, Waisman Ari, Walker Rachael V., Wallace Paul K., Wang Sa A., Wang Xin M., Ward Michael D., Ward-Hartstonge Kirsten A., Warnatz Klaus, Warnes Gary, Warth Sarah, Waskow Claudia, Watson James V., Watzl Carsten, Wegener Leonie, Weisenburger Thomas, Wiedemann Annika, Wienands J. rgen, Wilharm Anneke, Wilkinson Robert John, Willimsky Gerald, Wing James B., Winkelmann Rieke, Winkler Thomas H., Wirz Oliver F., Wong Alicia, Wurst Peter, Yang Jennie H. M., Yang Juhao, Yazdanbakhsh Maria, Yu Liping, Yue Alice, Zhang Hanlin, Zhao Yi, Ziegler Susanne Maria, Zielinski Christina, Zimmermann Jakob, Zychlinsky Arturo Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) European journal of immunology 2019;49 (10):1457-1973 [PubMed]
  • Bloemen P. R., de Rond L., van der Pol E., van Leeuwen T. G., Coumans F. A. W. Improved forward scatter detection of a flow cytometer for detection of extracellular vesiclesin: J. Quincy Brown, Ton G. van Leeuwen, editors. Clinical and Preclinical Optical Diagnostics II. SPIE; 2019.
  • Bloemen P. R., de Rond L., van der Pol E., van Leeuwen T. G., Coumans F. A. W. Improved forward scatter detection of a flow cytometer for detection of extracellular vesiclesin: European Conference on Biomedical Optics, ECBO_2019. OSA - The Optical Society; 2019.
  • Gasecka Aleksandra, Nieuwland Rienk, van der Pol Edwin, Hajji Najat, Cwiek Agata, Pluta Kinga, Konwerski Michał, Filipiak Krzysztof J. P2y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets Cardiology journal 2019;26 (6):782-789 [PubMed]
  • Pieragostino Damiana, Lanuti Paola, Cicalini Ilaria, Cufaro Maria Concetta, Ciccocioppo Fausta, Ronci Maurizio, Simeone Pasquale, Onofrj Marco, van der Pol Edwin, Fontana Antonella, Marchisio Marco, del Boccio Piero Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis Journal of proteomics 2019;204 [PubMed]
  • de Rond L., Libregts S. F. W. M., Rikkert L. G., Hau C. M., van der Pol E., Nieuwland R., van Leeuwen T. G., Coumans F. A. W. Refractive index to evaluate staining specificity of extracellular vesicles by flow cytometry Journal of extracellular vesicles 2019;8 (1) [PubMed]
  • Geeurickx Edward, Tulkens Joeri, Dhondt Bert, van Deun Jan, Lippens Lien, Vergauwen Glenn, Heyrman Elisa, de Sutter Delphine, Gevaert Kris, Impens Francis, Miinalainen Ilkka, van Bockstal Pieter-Jan, de Beer Thomas, Wauben Marca H. M., Nolte-‘t-Hoen Esther N. M., Bloch Katarzyna, Swinnen Johannes V., van der Pol Edwin, Nieuwland Rienk, Braems Geert, Callewaert Nico, Mestdagh Pieter, Vandesompele Jo, Denys Hannelore, Eyckerman Sven, de Wever Olivier, Hendrix An The generation and use of recombinant extracellular vesicles as biological reference material Nature communications 2019;10 (1) [PubMed]
  • Gasecka Aleksandra, Nieuwland Rienk, Budnik Monika, Dignat-George Françoise, Eyileten Ceren, Harrison Paul, Lacroix Romaric, Leroyer Aurélie, Opolski Grzegorz, Pluta Kinga, van der Pol Edwin, Postuła Marek, Siljander Pia, Siller-Matula Jolanta M., Filipiak Krzysztof J. Ticagrelor attenuates the increase of extracellular vesicle concentrations in plasma after acute myocardial infarction compared to clopidogrel Journal of thrombosis and haemostasis 2019 [PubMed]

2018

  • van der Pol Edwin, de Rond Leonie, Coumans Frank A. W., Gool Elmar L., Böing Anita N., Sturk Auguste, Nieuwland Rienk, van Leeuwen Ton G. Absolute sizing and label-free identification of extracellular vesicles by flow cytometry Nanomedicine: nanotechnology, biology and medicine 2018;14 (3):801-810 [PubMed]
  • Rikkert Linda G, van der Pol Edwin, van Leeuwen Ton G, Nieuwland Rienk, Coumans Frank A W Centrifugation affects the purity of liquid biopsy-based tumor biomarkers Cytometry. Part A 2018;93 (12):1207-1212 [PubMed]
  • de Rond Leonie, van der Pol Edwin, Hau Chi M., Varga Zoltan, Sturk Auguste, van Leeuwen Ton G., Nieuwland Rienk, Coumans Frank A. W. Comparison of Generic Fluorescent Markers for Detection of Extracellular Vesicles by Flow Cytometry Clinical chemistry 2018;64 (4):680-689 [PubMed]
  • de Rond Leonie, Coumans Frank A. W., Nieuwland Rienk, van Leeuwen Ton G., van der Pol Edwin Deriving Extracellular Vesicle Size From Scatter Intensities Measured by Flow Cytometry Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2018;86 (1) [PubMed]
  • Gąsecka Aleksandra, van der Pol Edwin, Nieuwland Rienk, Stępień Ewa Extracellular vesicles in post-infarct ventricular remodelling Kardiologia polska 2018;76 (1):69-76 [PubMed]
  • Varga Z., van der Pol E., Pálmai M., Garcia-Diez R., Gollwitzer C., Krumrey M., Fraikin J. L., Gasecka A., Hajji N., van Leeuwen T. G., Nieuwland R. Hollow organosilica beads as reference particles for optical detection of extracellular vesicles Journal of thrombosis and haemostasis 2018;16 (8):1646-1655 [PubMed]
  • van der Pol E., Sturk A., van Leeuwen T., Nieuwland R., Coumans F., Mobarrez F., Arkesteijn G., Wauben M., Siljander P. R. M., Sánchez-López V., Otero-Candelera R., Ramón L. A., Dolz S., Vila V., Mackman N., Geddings J., Mullier F., Bailly N., Han J. Y., Kwaan H. C., Weiss I. M., Buzás E. I., Pállinger E., Harrison P., Kraan J., Hedley B. D., LazoLangner A., Enjeti A., Norris P. J., Paris C., Susen S., Bonnefoy A., Delorme I., Chandler W. L., Hau C., Aass H. C. D., Connor D., Wu X., Dragovic R., Uotila L. M., Lacroix R., Robert S. Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation Journal of thrombosis and haemostasis 2018;16 (6):1236-1245 [PubMed]

2017

  • Valkonen S., van der Pol E., Böing A., Yuana Y., Yliperttula M., Nieuwland R., Laitinen S., Siljander P. R. M. Biological reference materials for extracellular vesicle studies European journal of pharmaceutical sciences 2017;98:4-16 [PubMed]
  • van der Pol Edwin, Harrison Paul From platelet dust to gold dust: physiological importance and detection of platelet microvesicles Platelets 2017;28 (3):211-213 [PubMed]
  • Coumans Frank A. W., Brisson Alain R., Buzas Edit I., Dignat-George Françoise, Drees Esther E. E., El-Andaloussi Samir, Emanueli Costanza, Gasecka Aleksandra, Hendrix An, Hill Andrew F., Lacroix Romaric, Lee Yi, van Leeuwen Ton G., Mackman Nigel, Mäger Imre, Nolan John P., van der Pol Edwin, Pegtel D. Michiel, Sahoo Susmita, Siljander Pia R. M., Sturk Guus, de Wever Olivier, Nieuwland Rienk Methodological Guidelines to Study Extracellular Vesicles Circulation research 2017;120 (10):1632-1648 [PubMed]

2016

  • Nicolet Anais, Meli Felix, van der Pol Edwin, Yuana Yuana, Gollwitzer Christian, Krumrey Michael, Cizmar Petr, Buhr Egbert, Petry Jasmine, Sebaihi Noham, de Boeck Bert, Fokkema Vincent, Bergmans Rob, Nieuwland Rienk Inter-laboratory comparison on the size and stability of monodisperse and bimodal synthetic reference particles for standardization of extracellular vesicle measurements MEASUREMENT SCIENCE & TECHNOLOGY 2016;27 (3):035701
  • Cernohorsky Paul, Jansen Sanne M., de Bruin Daniël M., van der Pol Edwin, Savci-Heijink Cemile D., Strackee Simon D., Faber Dirk J., van Leeuwen Ton G. Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 2016;22 (3):6801407
  • van der Pol E., Böing A. N., Gool E. L., Nieuwland R. Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles Journal of thrombosis and haemostasis 2016;14 (1):48-56 [PubMed]
  • van der Pol E., Mudde Y. D., Coumans F. A. W., van Leeuwen T. G., Sturk A., Nieuwland R. Wound scabs protect regenerating tissue against harmful ultraviolet radiation Medical hypotheses 2016;96:39-41 [PubMed]

2015

  • van der Pol Edwin Detection of extracellular vesicles: size does matter 2015. 222p. ISBN 9789462950696. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Leeuwen A. G. J. M., Sturk A.; Co-supervisor: Nieuwland R.)
  • Yuana Yuana, Böing Anita N., Grootemaat Anita E., van der Pol Edwin, Hau Chi M., Cizmar Petr, Buhr Egbert, Sturk Auguste, Nieuwland Rienk Handling and storage of human body fluids for analysis of extracellular vesicles Journal of extracellular vesicles 2015;4:29260 [PubMed]

2014

  • van der Pol E., Coumans F. A. W., Grootemaat A. E., Gardiner C., Sargent I. L., Harrison P., Sturk A., van Leeuwen T. G., Nieuwland R. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing Journal of thrombosis and haemostasis 2014;12 (7):1182-1192 [PubMed]
  • van der Pol Edwin, Coumans Frank A. W., Sturk Auguste, Nieuwland Rienk, van Leeuwen Ton G. Refractive Index Determination of Nanoparticles in Suspension Using Nanoparticle Tracking Analysis Nano letters 2014;14 (11):6195-6201 [PubMed]
  • Coumans Frank A. W., van der Pol Edwin, Böing Anita N., Hajji Najat, Sturk Guus, van Leeuwen Ton G., Nieuwland Rienk Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing Journal of extracellular vesicles 2014;3:25922 [PubMed]
  • Böing Anita N., van der Pol Edwin, Grootemaat Anita E., Coumans Frank A. W., Sturk Auguste, Nieuwland Rienk Single-step isolation of extracellular vesicles by size-exclusion chromatography Journal of extracellular vesicles 2014;3:23430 [PubMed]
  • Varga Zoltán, Yuana Yuana, Grootemaat Anita E., van der Pol Edwin, Gollwitzer Christian, Krumrey Michael, Nieuwland Rienk Towards traceable size determination of extracellular vesicles Journal of extracellular vesicles 2014;3:23298 [PubMed]

2013

  • Nguyen V. Duc, Faber D. J., van der Pol E., van Leeuwen T. G., Kalkman J. Dependent and multiple scattering in transmission and backscattering optical coherence tomography Optics express 2013;21 (24):29145-29156 [PubMed]
  • van der Pol E., Coumans F., Varga Z., Krumrey M., Nieuwland R. Innovation in detection of microparticles and exosomes Journal of thrombosis and haemostasis 2013;11 (Suppl. 1):36-45 [PubMed]

2012

  • van der Pol Edwin, Böing Anita N., Harrison Paul, Sturk Augueste, Nieuwland Rienk Classification, Functions, and Clinical Relevance of Extracellular Vesicles Pharmacological reviews 2012;64 (3):676-705 [PubMed]
  • Coumans Frank A. W., van der Pol Edwin, Terstappen Leon W. M. M. Flat-top illumination profile in an epifluorescence microscope by dual microlens arrays Cytometry. Part A 2012;81A (4):324-331 [PubMed]
  • Nieuwland R., van der Pol E., Gardiner C., Sturk A. Platelet-Derived Microparticlesin: A. D. Michelson, editors. Platelets. San Diego: Academic Press; 2012. p. 453-467, ISBN 9780123878373
  • van der Pol E., van Gemert M. J. C., Sturk A., Nieuwland R., van Leeuwen T. G. Single vs. swarm detection of microparticles and exosomes by flow cytometry Journal of thrombosis and haemostasis 2012;10 (5):919-930 [PubMed]
  • van den Akker Jeroen, van Weert Angela, Afink Gijs, Bakker Erik N. T. P., van der Pol Edwin, Böing Anita N., Nieuwland Rienk, VanBavel Ed Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation Amino acids 2012;42 (2-3):961-973 [PubMed]

2010

  • van der Pol E., Hoekstra A. G., Sturk A., Otto C., van Leeuwen T. G., Nieuwland R. Optical and non-optical methods for detection and characterization of microparticles and exosomes Journal of thrombosis and haemostasis 2010;8 (12):2596-2607 [PubMed]