G. Hamer PhD publications

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Publications PhD G. Hamer

Positions
Associate Professor, Research Associate
Main activities
Research
Specialisation
Reproductive Biology
Focus of research

While the genomes present in our somatic cells inevitably disappear upon death, our germ cells can pass on our genes to, in principal, endless generations of offspring. For this reason genome integritity maintenance is differentially regulated in the germline, which includes the preimplantation embryonic stem cells. 

The work of Geert Hamer focusses on genome stability maintenance and development of germ cells and human preimplantation embryos. For instance, he and co-workers unravelled the mechanisms that lead to meiotic arrest during human spermatogenesis and recently discovered a miRNA that is specifically secreted by, and aids implantation of, good quality (euploid) human embryos. In addition, one of Geert Hamer's students succeeded to induce spermatogonial differentiation and meiosis in vitro, a technique that is currently explored in many laboratories for fertilty treatment or preservation. However, current results show that meiotic checkpoints, normally required to prevent genomic instability and aneuploidies to be transmitted to the offspring, are not necessarily active in vitro. In vitro generated spermatid-like cells should thus be thoroughly investigated before being considered for clinical use. 

Geert Hamer and colleagues were the first the publish the transcriptome of human male germ cells. This study formed the basis of a novel research line that focusses on the role germ cell-specific genes in the development and treatment of cancer. For this research he recently won the prestigious Snoo-award for developmental biology and an Amsterdam Reproduction & Development (AR&D) research grant. 

Moreover, Geert Hamer is co-writer of a granted ZonMW Translational Research Program, in which he will be co-promotor and supervisor of a PhD student that will study the influence of different culture media on genome intergrity maintenance and quality of human preimplanation embryo's in an IVF setting.

 

https://orcid.org/0000-0002-9583-6796

Amsterdam UMC Research Institutes
AMC departments
All publications

2020

  • Smits Myrthe A. J., van Maarle Merel, Hamer Geert, Mastenbroek Sebastiaan, Goddijn Mariëtte, van Wely Madelon Cytogenetic testing of pregnancy loss tissue: a meta-analysis Reproductive biomedicine online 2020;40 (6):867-879 [PubMed]
  • Chen Xiaoxu, Zheng Yi, Lei Anmin, Zhang Hanxue, Niu Huimin, Li Xueliang, Zhang Pengfei, Liao Mingzhi, Lv Yinghua, Zhu Zhendong, Pan Chuanying, Dong Wuzi, Chen Hong, Wu De, Liu Wansheng, Hamer Geert, Zeng Shenming, Zeng Wenxian Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG-derived small RNAs present in mature spermatozoa Journal of biological chemistry 2020;295 (32):10885-10900 [PubMed]
  • Berkhout Robbert P., Keijser Remco, Repping Sjoerd, Lambalk Cornelis B., Afink Gijs B., Mastenbroek Sebastiaan, Hamer Geert High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a Human reproduction (Oxford, England) 2020;35 (8):1797-1807 [PubMed]
  • Lei Qijing, Lai Xin, Eliveld Jitske, Chuva de Sousa Lopes Susana M., van Pelt Ans M. M., Hamer Geert In Vitro Meiosis of Male Germline Stem Cells Stem cell reports 2020;15 (5):1140-1153 [PubMed]
  • Berkhout Robbert P, Lambalk Cornelis B, Repping Sjoerd, Hamer Geert, Mastenbroek Sebastiaan Premature expression of the decidualization marker prolactin is associated with repeated implantation failure Gynecological endocrinology 2020;36 (4):360-364 [PubMed]
  • Bruggeman Jan Willem, Irie Naoko, Lodder Paul, van Pelt Ans M.M., Koster Jan, Hamer Geert Tumors widely express hundreds of embryonic germline genes Cancers 2020;12 (12):1-16 [PubMed]

2019

  • Berkhout Robbert P. Insights into embryo implantation in humans 2019. 155p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Repping S. , Lambalk C. B.; Co-supervisors: Mastenbroek S. , Hamer G.)
  • Smits M A J, Hamer G, Lambalk C B, Goddijn M Responsibility of scientific community in claiming to have found an association with recurrent pregnancy loss Journal of reproductive immunology 2019;134-135:34 [PubMed]
  • Tarahomi M, Vaz F M, Straalen J P van, Schrauwen F A P, Wely M van, Hamer G, Repping S, Mastenbroek S The composition of human preimplantation embryo culture media and their stability during storage and culture Human reproduction (Oxford, England) 2019;34 (8):1450-1461 [PubMed]
  • Faisal Imrul, Cisneros-Montalvo Sheyla, Hamer Geert, Tuominen Minna M., Laurila Pirkka-Pekka, Tumiati Manuela, Jauhiainen Matti, Kotaja Noora, Toppari Jorma, Mäkelä Juho-Antti, Kauppi Liisa Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice Endocrinology 2019;160 (5):1119-1136 [PubMed]

2018

  • Hwang G., Verver D. E., Handel M. A., Hamer G., Jordan P. W. Depletion of SMC5/6 sensitizes male germ cells to DNA damage Molecular biology of the cell 2018;29 (25):3003-3016 [PubMed]
  • Jan Sabrina Z., Jongejan Aldo, Korver Cindy M., van Daalen Saskia K. M., van Pelt Ans M. M., Repping Sjoerd, Hamer Geert Distinct prophase arrest mechanisms in human male meiosis Development (Cambridge, England) 2018;145 (16) [PubMed]
  • Zheng Yi Genome integrity maintenance during spermatogonial development 2018. 164p. ISBN 9789463323079. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Repping S.; Co-supervisor: Hamer G.)
  • Berkhout R. P., Lambalk C. B., Huirne J., Mijatovic V., Repping S., Hamer G., Mastenbroek S. High-quality human preimplantation embryos actively influence endometrial stromal cell migration Journal of assisted reproduction and genetics 2018;35 (4):659–667 [PubMed]
  • Bruggeman Jan Willem, Koster Jan, Lodder Paul, Repping Sjoerd, Hamer Geert Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development Oncogene 2018;37 (42):5694-5700 [PubMed]
  • Hamer Geert, de Rooij Dirk G. Mutations causing specific arrests in the development of mouse primordial germ cells and gonocytes Biology of reproduction 2018;99 (1):75-86 [PubMed]
  • Tarahomi Majid, de Melker Annemieke A., van Wely Madelon, Hamer Geert, Repping Sjoerd, Mastenbroek Sebastiaan pH stability of human preimplantation embryo culture media: effects of culture and batches Reproductive biomedicine online 2018;37 (4):409-414 [PubMed]
  • Meng Li, Jan Sabrina Z., Hamer Geert, van Pelt Ans M., van der Stelt Inge, Keijer Jaap, Teerds Katja J. Preantral follicular atresia occurs mainly through autophagy, while antral follicles degenerate mostly through apoptosis Biology of reproduction 2018;99 (4):853-863 [PubMed]
  • Zheng Yi, Lei Qijing, Jongejan Aldo, Mulder Callista L., van Daalen Saskia K. M., Mastenbroek Sebastiaan, Hwang Grace, Jordan Philip W., Repping Sjoerd, Hamer Geert The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells DNA repair 2018;70:55-66 [PubMed]
  • Jan Sabrina Z. The molecular fingerprint of human spermatogenesis 2018. ISBN 9789463610919. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Repping S., van Pelt A. M. M.; Co-supervisor: Hamer G.)

2017

  • Berkhout R P, Vergouw C G, van Wely M, de Melker A A, Schats R, Repping S, Hamer G, Mastenbroek S, Lambalk C B The addition of a low-quality embryo as part of a fresh day 3 double embryo transfer does not improve ongoing pregnancy rates Human reproduction open 2017;2017 (3):hox020 [PubMed]
  • Zheng Yi, Jongejan Aldo, Mulder Callista L., Mastenbroek Sebastiaan, Repping Sjoerd, Wang Yinghua, Li Jinsong, Hamer Geert Trivial role for NSMCE2 during in vitro proliferation and differentiation of male germline stem cells Reproduction (Cambridge, England) 2017;154 (3):181-195 [PubMed]
  • Jan Sabrina Z., Vormer Tinke L., Jongejan Aldo, Röling Michael D., Silber Sherman J., de Rooij Dirk G., Hamer Geert, Repping Sjoerd, van Pelt Ans M. M. Unraveling transcriptome dynamics in human spermatogenesis Development (Cambridge, England) 2017;144 (20):3659-3673 [PubMed]

2016

  • Cissen Maartje, Wely Madelon van, Scholten Irma, Mansell Steven, Bruin Jan Peter de, Mol Ben Willem, Braat Didi, Repping Sjoerd, Hamer Geert Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis PLoS ONE 2016;11 (11):e0165125 [PubMed]
  • Verver Dideke E., Zheng Yi, Speijer Dave, Hoebe Ron, Dekker Henk L., Repping Sjoerd, Stap Jan, Hamer Geert Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress International journal of molecular sciences 2016;17 (11):1782 [PubMed]
  • Verver Dideke E., Hwang Grace H., Jordan Philip W., Hamer Geert Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6 Chromosoma 2016;125 (1):15-27 [PubMed]
  • Mulder Callista L., Zheng Yi, Jan Sabrina Z., Struijk Robert B., Repping Sjoerd, Hamer Geert, van Pelt Ans M. M. Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases Human reproduction update 2016;22 (5):561-573 [PubMed]

2015

  • Hendriks Saskia, Dancet Eline A. F., van Pelt Ans M. M., Hamer Geert, Repping Sjoerd Artificial gametes: a systematic review of biological progress towards clinical application Human reproduction update 2015;21 (3):285-296 [PubMed]
  • Hendriks Saskia, Dondorp Wybo, de Wert Guido, Hamer Geert, Repping Sjoerd, Dancet Eline A. F. Potential consequences of clinical application of artificial gametes: a systematic review of stakeholder views Human reproduction update 2015;21 (3):297-309 [PubMed]
  • Verver Dideke Emma SMC5/6: Shaping, protecting and preparing the genome for safe reproduction 2015. 123p. ISBN 9789462330481. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Repping S.; Co-supervisor: Hamer G.)
  • Joustra Sjoerd D., Meijer Onno C., Heinen Charlotte A., Mol Isabel M., Laghmani El Houari, Sengers Rozemarijn M. A., Carreno Gabriela, van Trotsenburg A. S. Paul, Biermasz Nienke R., Bernard Daniel J., Wit Jan M., Oostdijk Wilma, van Pelt Ans M. M., Hamer Geert, Wagenaar Gerry T. M. Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat Journal of endocrinology 2015;226 (3):181-191 [PubMed]

2014

  • Verver Dideke E., Langedijk Nathalia S. M., Jordan Philip W., Repping Sjoerd, Hamer Geert The SMC5/6 complex is involved in crucial processes during human spermatogenesis Biology of reproduction 2014;91 (1):22 [PubMed]

2013

  • Verver D. E., van Pelt A. M. M., Repping S., Hamer G. Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis Cell death & disease 2013;4:e749 [PubMed]

2012

  • Jan Sabrina Z., Hamer Geert, Repping Sjoerd, de Rooij Dirk G., van Pelt Ans M. M., Vormer Tinke L. Molecular control of rodent spermatogenesis BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (12):1838-1850 [PubMed]

2010

  • Hamer Geert, Matilainen Olli, Holmberg Carina I. A photoconvertible reporter of the ubiquitin-proteasome system in vivo Nature methods 2010;7 (6):473-478 [PubMed]

2008

  • Hamer G., Novak I., Kouznetsova A., Höög C. Disruption of pairing and synapsis of chromosomes causes stage-specific apoptosis of male meiotic cells Theriogenology 2008;69 (3):333-339 [PubMed]
  • Hamer Geert, Wang Hong, Bolcun-Filas Ewelina, Cooke Howard J., Benavente Ricardo, Höög Christer Progression of meiotic recombination requires structural maturation of the central element of the synaptonemal complex Journal of cell science 2008;121 (Part 15):2445-2451 [PubMed]

2006

  • Hamer Geert, Gell Katarina, Kouznetsova Anna, Novak Ivana, Benavente Ricardo, Höög Christer Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex Journal of cell science 2006;119 (Part 19):4025-4032 [PubMed]

2004

  • Hamer Geert, Kal Henk B., Westphal Christoph H., Ashley Terry, de Rooij Dirk G. Ataxia telangiectasia mutated expression and activation in the testis Biology of reproduction 2004;70 (4):1206-1212 [PubMed]

2003

  • Hamer Geert, Roepers-Gajadien Hermien L., van Duyn-Goedhart Annemarie, Gademan Iris S., Kal Henk B., van Buul Paul P. W., de Rooij Dirk G. DNA double-strand breaks and gamma-H2AX signaling in the testis Biology of reproduction 2003;68 (2):628-634 [PubMed]
  • Hamer Geert, Roepers-Gajadien Hermien L., van Duyn-Goedhart Annemarie, Gademan Iris S., Kal Henk B., van Buul Paul P. W., Ashley Terry, de Rooij Dirk G. Function of DNA-protein kinase catalytic subunit during the early meiotic prophase without Ku70 and Ku86 Biology of reproduction 2003;68 (3):717-721 [PubMed]
  • Hamer Geert, Roepers-Gajadien Hermien L., Gademan Iris S., Kal Henk B., de Rooij Dirk G. Intercellular bridges and apoptosis in clones of male germ cells International journal of andrology 2003;26 (6):348-353 [PubMed]

2001

  • Hamer G., Gademan I. S., Kal H. B., de rooij D. G. Role for c-Abl and p73 in the radiation response of male germ cells Oncogene 2001;20 (32):4298-4304 [PubMed]
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