- Baas Inge, Delvasto-Nuñez Laura, Ligthart Peter, Brouwer Conny, Folman Claudia, Reis Edimara S., Ricklin Daniel, Lambris John D., Wouters Diana, de Haas Masja, Jongerius Ilse, Zeerleder Sacha S. Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells Haematologica 2020;105 (2):e57-e60 [PubMed]
- Hovingh Elise S., van den Broek Bryan, Kuipers Betsy, Pinelli Elena, Rooijakkers Suzan H. M., Jongerius Ilse Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface PLoS pathogens 2017;13 (7) [PubMed]
- Hovingh Elise S., de Maat Steven, Cloherty Alexandra P. M., Johnson Steven, Pinelli Elena, Maas Coen, Jongerius Ilse Virulence associated gene 8 of Bordetella pertussis enhances contact system activity by inhibiting the regulatory function of complement regulator C1 inhibitor Frontiers in immunology 2018;9 (JUN) [PubMed]
- Jongerius Ilse, Lavender Hayley, Tan Lionel, Ruivo Nicola, Exley Rachel M, Caesar Joseph J E, Lea Susan M, Johnson Steven, Tang Christoph M Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein PLoS pathogens 2013;9 (8):e1003528 [PubMed]
- Ko Ya-Ping, Kuipers Annemarie, Freitag Claudia M, Jongerius Ilse, Medina Eva, van Rooijen Willemien J, Spaan András N, van Kessel Kok P M, Höök Magnus, Rooijakkers Suzan H M Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface PLoS pathogens 2013;9 (12):e1003816 [PubMed]
Ilse Jongerius
Pr. Dr. W. Einthovenweg 3,
3731 KN de Bilt
i.jongerius@sanquin.nl
Profile
An experienced and committed scientist, in the field of innate immunity, with specific focus on the complement system, and bacteriology who is purposefully efficient and likes a challenge. Planning, problem solving, coordinating and people management are my major skills. I have obtained several personal grants and have published in high impact, peer-reviewed international journals. I have an extensive international network due to my international experience and international collaborations.
Work experience
2018-present Group Leader complement research, Sanquin research, Department of Immunopathology, NL
2014-2018 Assistant professor (Veni laureate), Department of Medical Microbiology, University Medical Center Utrecht (UMCU), NL
2013-2014 Post-doctoral researcher, National Institute for Public Health and the Environment (RIVM), Center for Immunology of Infectious Diseases and Vaccines, NL
2010-2013 Rubicon fellow, Sir Williman Dunn School of Pathology, Oxford University, UK; MCR Centre for Molecular Bacteriology and Infection, Imperial College London, UK
My research focus and interest have always been “infection and immunity with emphasis on the complement system and bacterial evasion”. Today as group leader of the complement research at Sanquin my focus is shifting towards complement regulation of the human host. I have managed both my Veni and Rubicon projects and now supervising a group of 8 people consisting of a post doc, 3 PhD students and 4 technicians. My publication track record includes several first and last authorships in peer reviewed journals. I have obtained several prestigious personal grants and presented my data on several (inter)national conferences. I have great pleasure in teaching students and have recently received my qualification to teach in higher eduction (BKO- basiskwalifikatie onderwijs). I am lecturer and workgroup leader, at several master courses and summer schools and tutor of several Biomedical students at the UMCU and AMC.
Co-promotor Elise Hovingh, UU
Unravalling the interactions between Bordetella pertussis and the innate immune system
3 may 2018
Anna van Beek, AMC
Factor H family proteins in pediatric infectious diseases
Date doctoral degree 27th of September 2019
Laura Delvasto Nunez
Complement activation and neutrophil extracellular traps in de pathogenesis of thrombosis in autoimmune hemolytic anemia
Expected date doctoral degree 2021
Judith Zandstra
Identification and validation of new biomarkers to distinguish between bacterial or viral infection in children
Expected date doctoral degree 2021
Education
2005-2010 PhD thesis “Complement evasion of Staphylococcus aureus” Department of Medical Microbiology, UMCU, NL
2001-2005 Doctorate Biology, University Utrecht, NL
2000-2001 Propedeuse Biology, University Utrecht, NL
1994-2000 V.W.O.-atheneum, Minkema College, Woerden, NL
Grants and awards
2018 Contract research Gemini therapeutics (Co-Applicant €327.000,-)
2014 VENI – NWO ZonMw (personal grant, €250.000,-)
2012 Meningitidis UK – co-applicant (€190000,-)
2010 NWO Rubicion – NWO ZonMw/ALW (personal grant, €147200,-)
2010 EMBO Long-Term Fellowship – kindly declined (personal grant)
2008 International Complement Workshop travel award
2008 Dutch “kiemprijs”: award for best first Medical Microbiology article of PhD students
2007 DLA Science Meeting: award for best PhD abstract
2007 American Society for Microbiology: Corporate Activities Program Student Travel Grant
Personal skills
BKO Basiskwalificatie onderwijs, teaching in higher education
Licenses Animal license (2011, UK), radiation protection (2008, NL)
Languages Dutch (Native), English (excellent verbally and in writing)
Personal interest Sports (gym, tennis and running), reading and like to participate in social events, spending time with my family
Character qualities Social and contact capable, work in a team but also independent, resolute, efficient
References: Upon request
Publications
- Baas I*, Delvasto-Nuñez L*, Ligthart P, Brouwer C, Folman C, Reis ES, Ricklin D, Lambris JD, Wouters D, de Haas M, Jongerius I*, Zeerleder SS*. Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells. Haematologica. 2019 Jun 6. pii: haematol.2019.216028. doi: 10.3324/haematol.2019.216028
- Rijkers M, Schmidt D, Lu N, Kramer CSM, Heidt S, Mulder A, Porcelijn L, Claas FHJ, Leebeek FWG, Jansen AJG, Jongerius I, Zeerleder SS, Vidarsson G, Voorberg J, de Haas M. Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets. Haematologica. 2018 doi: 10.3324/haematol.2018.201665.
- van Beek AE, Kamp A, Kruithof S, Nieuwenhuys EJ, Wouters D, Jongerius I, Rispens T, Kuijpers TW, Gelderman KA. Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children. Front Immunol. 2018 doi, 10.3389/fimmu.2018.01727.
- Hovingh ES, Kuipers B, Bonačić Marinović AA, Jan Hamstra H, Hijdra D, Mughini Gras L, van Twillert I, Jongerius I, van Els CACM, Pinelli E. Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients. Sci Rep. 2018, doi, 10.1038/s41598-018-30558-8.
- Hovingh ES, de Maat S, Cloherty APM, Johnson S, Pinelli E, Maas C, Jongerius I. Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor. Front Immunol. 2018 doi: 10.3389/fimmu.2018.01172.
- Hovingh ES, Mariman R, Solans L, Hijdra D, Hamstra HJ, Jongerius I, van Gent M, Mooi F, Locht C, Pinelli E. Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor. Emerg Microbes Infect. 2018, doi, 10.1038/s41426-018-0039-8.
- Hollingshead S, Jongerius I, Exley RM, Johnson S, Lea SM, Tang CM. Structure-based design of chimeric antigens for multivalent protein vaccines. Nat Commun. 2018, doi, 10.1038/s41467-018-03146-7.
- Hovingh, E.S., van den Broek, B., Pinelli, E., Kuipers, B., Rooijakkers, S.H.M., and Jongerius, I. Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface. Plos Pathogens. 2017, doi, 10.1371/journal.ppat.1006531.
- Hovingh E.S., van den Broek B, Jongerius I. Hijacking complement regulatory proteins for bacterial immune evasion. Front. Microbiol. 2016, doi: 10.3389/fmicb.2016.02004.
- Jongerius I, Schuijt TJ, Mooi FR, Pinelli E. Complement evasion by Bordetella pertussis: implications for improving current vaccines. J Mol Med (Berl). 2015 Apr;93(4):395-402. doi: 10.1007/s00109-015-1259-1.
- van der Veen, S., Johnson, S., Jongerius, I., Malik, T., De Jorge, E.G., Genovese, A., Santini, L., Staunton, D., Ufret-Vincenty, R., Pickering, M., Lea, S.M., and Tang, C.M. Non-Functional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine Candidates. Infect. Immun. 2014;82(3):1157-63. doi: 10.1128/IAI.01183-13.
- Ko. Y*., Kuipers A*., Freitag C.M*. Jongerius I*., Medina, E., van Rooijen, W.J., Spaan, A.N., van Kessel, K.P.M., Höök, M., and Rooijakkers, S.H.M. Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface. PLoS Pathog. 2013, e1003816.
- Amdahl, H., Jongerius, I., Meri, T., Pasanen, T., Hyvärinen, S., Haapasalo, K., van Strijp, J.A., Rooijakkers, S.H.M., and Jokiranta, T.S. Staphylococcal Ecb protein and host complement regulator factor H enhance functions of each other in bacterial immune evasion. J. Immunol., 2013, 191:1775-84.
- Jongerius, I., Lavender, H., Tan, L., Ruivo, N., Exley, R.M., Caesar, J.J., Lea, S.M., Johnson, S., and Tang C.M. Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor H binding protein. PLoS Pathog. 2013, 9(8):e1003528.
- Jongerius, I*., von Köckritz-Blickwede, M*., Horsbrugh, M.J., Ruyken, M., Nizet, V., and Rooijakkers, S.H.M. Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses. J. Innate Immun., 2012, 4:301-311.
- Stork, M., Bos, M.P., Jongerius, I., de Kok, N., Schilders, I., Weynants, V.E., Poolman., J.T., and Tommassen, J. An outer membrane receptor of Neisseria meningitidis involved in zinc acquisition with vaccine potential. PLoS Pathog. 2010, 6;e1000969.
- Roussel-Jazédé, V., Jongerius, I., Bos, M.P., Tommassen, J., and van Ulsen, P. NalP-mediated proteolytic release of lactoferrin-binding protein B from the meningococcal cell surface. Infect. Immun., 2010, 78:3083-3089.
- Jongerius, I., Ruyken, M., van Strijp, J.A.G., and Rooijakkers, S.H.M. Extracellular complement binding protein inhibits the formation of the catalytic subunits of convertases: C2a and Bb. J. Biol. Chem., 2010, 284:14973-14979.
- Ten Broeke-Smits., N., Pronk, T., Jongerius, I., Bruning, O, Wittink, F., Breit, T., van Strijp, J.A.G., Fluit, A., and Boel, E. Operon Structure of Staphylococcus aureus. Nucl. Acids Res., 2010, 38:3263-3274.
- Jongerius, I., Puister, M., Wu., J, Ruyken, M., van Strijp, J.A.G., and Rooijakkers, S.H.M. Immunomodulatory functions of convertase dimerization by S. aureus complement inhibitor. J.Immunol., 2010, 184:420-425.
- Jongerius, I., Köhl, J., Pandey, M.K., Ruyken, M., van Kessel, K.P.M., van Strijp, J.A.G., and Rooijakkers, S.H.M. Staphylococcal complement evasion by various convertase-blocking molecules. J. Exp. Med., 2007, 204:2461-2471.
*authors contribute equally
Book chapters
Jongerius, I., Ram, S., and Rooijakkers, S.H.M. Bacterial complement escape. Chapter of: Pathogen-Derived Immunomodulatory Molecules. ISBN: 978-1-58706-334-3 publication date: august 15, 2009.
Patents
- WO2014030003 (A1) NEISSERIA MENINGITIDIS FHBP VARIANT AND ITS USE FOR VACCINATION
- WO2014140562 (A1) IMMUNOGENIC COMPOSITION TO NEISSERIA
- GB1614687.0 MODIFIED FACTOR H BINDING PROTEIN (filed 31 August 2016).
- E.C.W. de Boer
- L.V. Delvasto Nunez
- B.R.J. Veuskens
- J. Zandstra