I. Klaassen PhD

foto

PhD I. Klaassen

Position
Assistant Professor
Main activities
Education, Research
Specialisation
Molecular mechanisms of vascular permeability and angiogenesis
Focus of research

www.ocular-angiogenesis.nl

Molecular mechanisms in retinal vascular disease, including diabetic retinopathy and age-related macular degeneration.

Special interest in the blood-retinal barrier, blood-brain barrier and microvascular permeability.

Molecular regulation of angiogenic tip cells/angiogenesis.

Biomarkers in eye disease.

Retinal and cognitive dysfunction in type 2 diabetes.

Amsterdam UMC Research Institutes
AMC departments
Key publications
  • Klaassen Ingeborg, van Noorden Cornelis J. F., Schlingemann Reinier O. Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions Progress in retinal and eye research 2013;34:19-48 [PubMed]
  • van der Wijk Anne-Eva, Wisniewska-Kruk Joanna, Vogels Ilse M. C., van Veen Henk A., Ip Wing Fung, van der Wel Nicole N., van Noorden Cornelis J. F., Schlingemann Reinier O., Klaassen Ingeborg Expression patterns of endothelial permeability pathways in the development of the blood-retinal barrier in mice FASEB journal 2019;33 (4):5320-5333 [PubMed]
  • Wisniewska-Kruk Joanna, van der Wijk Anne-Eva, van Veen Henk A., Gorgels Theo G. M. F., Vogels Ilse M. C., Versteeg Danielle, van Noorden Cornelis J. F., Schlingemann Reinier O., Klaassen Ingeborg Plasmalemma Vesicle-Associated Protein Has a Key Role in Blood-Retinal Barrier Loss American journal of pathology 2016;186 (4):1044-1054 [PubMed]
  • Bosma Esmeralda K., van Noorden Cornelis J. F., Schlingemann Reinier O., Klaassen Ingeborg The role of plasmalemma vesicle-associated protein in pathological breakdown of blood-brain and blood-retinal barriers: Potential novel therapeutic target for cerebral edema and diabetic macular edema Fluids and barriers of the CNS 2018;15 (1) [PubMed]
  • Wisniewska-Kruk Joanna, Hoeben Kees A., Vogels Ilse M. C., Gaillard Pieter J., van Noorden Cornelis J. F., Schlingemann Reinier O., Klaassen Ingeborg A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes Experimental eye research 2012;96 (1):181-190 [PubMed]
All Publications
Curriculum Vitae

Dr. Klaassen was trained at the University of Groningen (Molecular Biology and Biochemistry), VU University Amsterdam (Ph.D.), and the University of Amsterdam (Postdoc in Ophthalmology).

Research programmes

Prof. MD PhD R.O. Schlingemann (Ocular angiogenesis and Ocular imaging)

Current PhD Candidates
Current research funding
  • European Foundation for the Study of Diabetes
  • Oogfonds, voorheen MaculaFonds
  • Stichting AMC Foundation (Vrijgesteld)