I.C. Gaemers PhD publications

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Publications PhD I.C. Gaemers

Positions
Assistant Professor, Support Staff
Main activities
Other
Specialisation
Research Quality and Preclinical Project Management
Focus of research

Main activities (50/50)


• Tytgat Institute Research Quality management
The Tytgat Institute(TI) has an ISO15189 international accreditation for its research activities (Dutch Board of Accreditation, #M304) and is compliant with GcLP. For this I:
* design, implement and manage the TI quality system (QS)for research and preclinical studies
* am internal auditor and external auditor host
* perform Process analyses & Risk management
* validate processes, and coordinate equipment and assay validation
* perform Management Review of quality and general policy
* coordinate all aspects of TI Standard Operating Procedures (SOPs)
* train and inform TI staff on TI QS, auditing and risk management
* am SMART advisor for general management (Annual Plan, Action Plan, QPI’s)
* am Quality manual author

• (Pre)clinical Project Management:
The Tytgat Institute performs research and services for fee for external partners (pharma & CRO). For this I
* Manage all aspects of Tytgat Institute "external" preclinical studies (Set-up, Deliverables, Budget, Staff planning, Sample logistics, Data storage, Contracts and Invoicing)
* am Tytgat institute’s intermediair/contact for CRO and pharmaceutical companies

Contact:

i.c.gaemers@amsterdamumc.nl

www.tytgatresearchservices.com

Tel: +31205668832

 

 

Amsterdam UMC Research Institutes
AMC departments
All publications

2019

  • Novak Gregor, Stevens Toer, van Viegen Tanja, Bossuyt Peter, Štabuc Borut, Jeyarajah Jenny, Zou Guangyong, Gaemers Ingrid C., McKee Trevor D., Fu Fred, Shackelton Lisa M., Khanna Reena, van den Brink Gijs R., Sandborn William J., Feagan Brian G., Pai Rish K., Jairath Vipul, Vande Casteele Niels, D’Haens Geert Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn’s disease Alimentary pharmacology & therapeutics 2019;49 (11):1401-1409 [PubMed]

2018

  • Gasparin Fabiana Rodrigues Silva, Carreño Fernando Olinto, Mewes Juliana Moraes, Gilglioni Eduardo Hideo, Pagadigorria Clairce Luzia Salgueiro, Natali Maria Raquel Marçal, Utsunomiya Karina Sayuri, Constantin Rodrigo Polimeni, Ouchida Amanda Tomie, Curti Carlos, Gaemers Ingrid C., Elferink Ronald Petrus Johannes Oude, Constantin Jorgete, Ishii-Iwamoto Emy Luiza Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (7):2495-2509 [PubMed]

2016

  • de Oliveira Monique C., Gilglioni Eduardo H., de Boer Bouke A., Runge Jurgen H., de Waart Dirk R., Salgueiro Clairce L., Ishii-Iwamoto Emy L., Oude Elferink Ronald P. J., Gaemers Ingrid C. Bile acid receptor agonists. INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2016;1862 (11):2054-2062 [PubMed]
  • Runge Jurgen H., Bakker Pieter J., Gaemers Ingrid C., Verheij Joanne, Hakvoort Theo B.M., Ottenhoff Roel of, Stoker Jaap, Nederveen Aart J. Erratum to "Quantitative Determination of Liver Triglyceride Levels with 3T 1H-MR Spectroscopy in Mice with Moderately Elevated Liver Fat Content" [Acad Radiol 21 (2014) 1446-1454] Academic radiology 2016;23 (2):264

2015

  • van Diest Sophie A., van den Elsen Lieke W. J., Klok Allison J., Welting Olaf, Hilbers Francisca W., van de Heijning Bert J., Gaemers Ingrid C., Boeckxstaens Guy E., Werner Maria F., Willemsen Linette E. M., de Jonge Wouter J., van den Wijngaard René M. Dietary Marine n-3 PUFAs Do Not Affect Stress-Induced Visceral Hypersensitivity in a Rat Maternal Separation Model Journal of nutrition 2015;145 (5):915-922 [PubMed]

2014

  • Kunne Cindy, Acco Alexandra, Duijst Suzanne, de Waart Dirk R., Paulusma Coen C., Gaemers Ingrid, Oude Elferink Ronald P. J. FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (5):739-746 [PubMed]
  • Falix Farah A., Weeda Víola B., Labruyere Wilhelmina T., Poncy Alexis, de Waart Dirk R., Hakvoort Theodorus B. M., Lemaigre Frédéric, Gaemers Ingrid C., Aronson Daniël C., Lamers Wouter H. Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning Developmental biology 2014;396 (2):201-213 [PubMed]
  • Runge Jurgen H., Bakker Pieter J., Gaemers Ingrid C., Verheij Joanne, Hakvoort Theo B. M., Ottenhoff Roelof, Nederveen Aart J., Stoker Jaap Measuring liver triglyceride content in mice: non-invasive magnetic resonance methods as an alternative to histopathology Magma (New York, N.Y.) 2014;27 (4):317-327 [PubMed]
  • Runge Jurgen H., Bakker Pieter J., Gaemers Ingrid C., Verheij Joanne, Hakvoort Theo B. M., Ottenhoff Roelof, Stoker Jaap, Nederveen Aart J. Quantitative determination of liver triglyceride levels with 3T ¹H-MR spectroscopy in mice with moderately elevated liver fat content Academic radiology 2014;21 (11):1446-1454 [PubMed]

2013

  • Falix F. A., Tjon-A-Loi M. R. S., Gaemers I. C., Aronson D. C., Lamers W. H. DLK1 Protein Expression during Mouse Development Provides New Insights into Its Function ISRN developmental biology 2013;2013:628962
  • Schaap Frank G., Kremer Andreas E., Lamers Wouter H., Jansen Peter L. M., Gaemers Ingrid C. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress Biochimie 2013;95 (4):692-699 [PubMed]
  • Garcia-Caraballo Sonia C., Comhair Tine M., Verheyen Fons, Gaemers Ingrid, Schaap Frank G., Houten Sander M., Hakvoort Theodorus B. M., Dejong Cornelis H. C., Lamers Wouter H., Koehler S. Eleonore Prevention and reversal of hepatic steatosis with a high-protein diet in mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (5):685-695 [PubMed]

2012

  • Falix Farah A. DLK1 and the knotch pathway in the liver 2012. 171p. ISBN 9789461820754. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lamers W. H., Aronson D. C.; Co-supervisor: Gaemers I. C.)
  • Falix Farah A., Aronson Daniël C., Lamers Wouter H., Gaemers Ingrid C. Possible roles of DLK1 in the Notch pathway during development and disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (6):988-995 [PubMed]

2011

  • Gaemers Ingrid C., Stallen Jan M., Kunne Cindy, Wallner Christian, van Werven Jochem, Nederveen Aart, Lamers Wouter H. Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2011;1812 (4):447-458 [PubMed]

2007

  • Schoneveld Onard J. L. M., Hoogenkamp Maarten, Stallen Jan M., Gaemers Ingrid C., Lamers Wouter H. cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstream regulatory units Biochimie 2007;89 (5):574-580 [PubMed]
  • Hoogenkamp Maarten, Gaemers Ingrid C., Schoneveld Onard J. L. M., Das Atze T., Grange Thierry, Lamers Wouter H. Hepatocyte-specific interplay of transcription factors at the far-upstream enhancer of the carbamoylphosphate synthetase gene upon glucocorticoid induction FEBS journal 2007;274 (1):37-45 [PubMed]
  • Hoogenkamp M. The in vivo regulation of the carbamoylphosphate synthetase I gene 2007. 117p. ISBN 9789090209760. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Lamers Wouter H.; Co-supervisor: Gaemers I. C.)

2006

  • Hoogenkamp M., Stallen J. M. P., Lamers W. H., Gaemers I. C. In vivo footprinting of the carbamoylphosphate synthetase I cAMP-response unit indicates important roles for FoxA and PKA in formation of the enhanceosome Biochimie 2006;88 (10):1357-1366 [PubMed]
  • Gaemers Ingrid C., Groen Albert K. New insights in the pathogenesis of non-alcoholic fatty liver disease Current opinion in lipidology 2006;17 (3):268-273 [PubMed]

2005

  • Schoneveld Onard J. L. M., Gaemers Ingrid C., Hoogenkamp Maarten, Lamers Wouter H. The role of proximal-enhancer elements in the glucocorticoid regulation of carbamoylphosphate synthetase gene transcription from the upstream response unit Biochimie 2005;87 (11):1033-1040 [PubMed]

2004

  • Schoneveld Onard J. L. M., Gaemers Ingrid C., Lamers Wouter H. Mechanisms of glucocorticoid signalling BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 2004;1680 (2):114-128 [PubMed]
  • Schoneveld Onard J. L. M., Gaemers Ingrid C., Das Atze T., Hoogenkamp Maarten, Renes Johan, Ruijter Jan M., Lamers Wouter H. Structural requirements of the glucocorticoid-response unit of the carbamoyl-phosphate synthase gene Biochemical journal 2004;382 (Part 2):463-470 [PubMed]
  • Schoneveld J. L. M. The hormonal regulation of carbamoylphosphate synthetase I expression 2004. 121p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Lamers W. H.; Co-supervisor: Gaemers I. C.)

2001

  • Gaemers I. C., Vos H. L., Volders H. H., van der Valk S. W., Hilkens J. A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells Journal of biological chemistry 2001;276 (9):6191-6199 [PubMed]

1998

  • Gaemers I. C., van Pelt A. M., van der Saag P. T., Hoogerbrugge J. W., Themmen A. P., de rooij D. G. Differential expression pattern of retinoid X receptors in adult murine testicular cells implies varying roles for these receptors in spermatogenesis Biology of reproduction 1998;58 (6):1351-1356 [PubMed]
  • Gaemers I. C., van Pelt A. M., Themmen A. P., de rooij D. G. Isolation and characterization of all-trans-retinoic acid-responsive genes in the rat testis Molecular reproduction and development 1998;50 (1):1-6 [PubMed]
  • Gaemers I. C., Sonneveld E., van Pelt A. M., Schrans B. H., Themmen A. P., van der Saag P. T., de rooij D. G. The effect of 9-cis-retinoic acid on proliferation and differentiation of a spermatogonia and retinoid receptor gene expression in the vitamin A-deficient mouse testis Endocrinology 1998;139 (10):4269-4276 [PubMed]

1997

  • Gaemers I. C., van Pelt A. M., van der Saag P. T., Hoogerbrugge J. W., Themmen A. P., de rooij D. G. Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis Endocrinology 1997;138 (4):1544-1551 [PubMed]

1996

  • Gaemers I. C., van Pelt A. M., van der Saag P. T., de rooij D. G. All-trans-4-oxo-retinoic acid: a potent inducer of in vivo proliferation of growth-arrested A spermatogonia in the vitamin A-deficient mouse testis Endocrinology 1996;137 (2):479-485 [PubMed]
  • van Pelt A. M., Morena A. R., van Dissel-Emiliani F. M., Boitani C., Gaemers I. C., de rooij D. G., Stefanini M. Isolation of the synchronized A spermatogonia from adult vitamin A-deficient rat testes Biology of reproduction 1996;55 (2):439-444 [PubMed]
  • Gaemers I. C., Van Pelt A. M.M., Van Der Saag P. T., Themmen A. P.N., De Rooij D. G. Role of retinoids in differentiation and proliferation of spermatogenic cells European journal of clinical nutrition 1996;50 (SUPPL. 3):S74-S75

1995

  • van Pelt A. M., van Dissel-Emiliani F. M., Gaemers I. C., van der Burg M. J., Tanke H. J., de rooij D. G. Characteristics of A spermatogonia and preleptotene spermatocytes in the vitamin A-deficient rat testis Biology of reproduction 1995;53 (3):570-578 [PubMed]
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