K.A. van Dort BEng publications

2020

• Kruize Zita, Maurer Irma, van Dort Karel A., van den Elshout Mark A. M., Hoornenborg Elske, Booiman Thijs, Prins Maria, Kootstra Neeltje A. Human immunodeficiency virus-negative men who have sex with men have an altered T-Cell phenotype and bioenergy metabolism Open forum infectious diseases 2020;7 (8) [PubMed]
• Stunnenberg Melissa, van Pul Lisa, Sprokholt Joris K., van Dort Karel A., Gringhuis Sonja I., Geijtenbeek Teunis B. H., Kootstra Neeltje A. MAVS genetic variation is associated with decreased HIV-1 replication in vitro and reduced cd4+ t cell infection in HIV-1-infected individuals Viruses 2020;12 (7) [PubMed]

2017

• Stelma Femke, Willemse Sophie B., Erken Robin, de Niet Annikki, Sinnige Marjan J., van Dort Karel, Zaaijer Hans L., van Leeuwen Ester M. M., Kootstra Neeltje A., Reesink Hendrik W. Dynamics of the Immune Response in Acute Hepatitis B Infection Open forum infectious diseases 2017;4 (4):UNSP ofx231 [PubMed]
• Gringhuis Sonja I., Hertoghs Nina, Kaptein Tanja M., Zijlstra-Willems Esther M., Sarrami-Fooroshani Ramin, Sprokholt Joris K., van Teijlingen Nienke H., Kootstra Neeltje A., Booiman Thijs, van Dort Karel A., Ribeiro Carla M. S., Drewniak Agata, Geijtenbeek Teunis B. H. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 Nature immunology 2017;18 (2):225-235 [PubMed]
• Gringhuis Sonja I., Hertoghs Nina, Kaptein Tanja M., Zijlstra-Willems Esther M., Sarrami-Fooroshani Ramin, Sprokholt Joris K., van Teijlingen Nienke H., Kootstra Neeltje A., Booiman Thijs, van Dort Karel A., Ribeiro Carla M. S., Drewniak Agata, Geijtenbeek Teunis B. H. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3 (vol 18, pg 225, 2017) Nature immunology 2017;18 (4):474 [PubMed]
• Stelma Femke, de Niet Annikki, Sinnige Marjan J., van Dort Karel A., van Gisbergen Klaas P. J. M., Verheij Joanne, van Leeuwen Ester M. M., Kootstra Neeltje A., Reesink Hendrik W. Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity Scientific reports 2017;7 (1):6172 [PubMed]
• van der Ree Meike H., Jansen Louis, Kruize Zita, van Nuenen Ad C., van Dort Karel A., Takkenberg R. Bart, Reesink Hendrik W., Kootstra Neeltje A. Plasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients Journal of infectious diseases 2017;215 (9):1421-1429 [PubMed]
• Jansen Louis, Welkers Matthijs R. A., van Dort Karel A., Takkenberg R. Bart, Lopatin Uri, Zaaijer Hans L., de Jong Menno D., Reesink Hendrik W., Kootstra Neeltje A. Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients Antiviral research 2017;145:87-95 [PubMed]

2016

• Jansen L., Kootstra Neeltje A., van Dort Karel A., Takkenberg R. Bart, Reesink Hendrik W., Zaaijer Hans L. Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues Journal of infectious diseases 2016;213 (2):224-232 [PubMed]
• Setiawan Laurentia C., van Dort Karel A., Rits Maarten A. N., Kootstra Neeltje A. Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages AIDS research and human retroviruses 2016;32 (4):390-398 [PubMed]

2015

• Cuadrado Eloy, Booiman Thijs, van Hamme John L., Jansen Machiel H., van Dort Karel A., Vanderver Adeline, Rice Gillian I., Crow Yanick J., Kootstra Neeltje A., Kuijpers Taco W. ADAR1 Facilitates HIV-1 Replication in Primary CD4(+) T Cells PLoS ONE 2015;10 (12):e0143613 [PubMed]
• Jansen Louis, de Niet Annikki, Makowska Zuzanna, Dill Michael T., van Dort Karel A., Terpstra Valeska, Bart Takkenberg R., Janssen Harry L. A., Heim Markus H., Kootstra Neeltje A., Reesink Hendrik W. An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B Liver international 2015;35 (7):1824-1832 [PubMed]
• Booiman Thijs, Loukachov Vladimir V., van Dort Karel A., van 't Wout Angélique B., Kootstra Neeltje A. DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner PLoS ONE 2015;10 (12):e0144229 [PubMed]
• Cobos Jiménez Viviana, Martinez Fernando O., Booiman Thijs, van Dort Karel A., van de Klundert Maarten A. A., Gordon Siamon, Geijtenbeek Teunis B. H., Kootstra Neeltje A. G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA Virology 2015;486:94-104 [PubMed]

2014

• Jansen Louis, de Niet Annikki, Stelma Femke, van Iperen Erik P. A., van Dort Karel A., Tempelmans Plat-Sinnige Marjan J., Takkenberg R. Bart, Chin Daniel J., Zwinderman A. H. Koos, Lopatin Uri, Kootstra Neeltje A., Reesink Hendrik W. HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels Journal of hepatology 2014;61 (4):730-737 [PubMed]
• Booiman Thijs, Cobos Jiménez Viviana, van Dort Karel A., van 't Wout Angélique B., Kootstra Neeltje A. Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription PLoS ONE 2014;9 (10):e109673 [PubMed]

2013

• Jazaeri Farsani Seyed Mohammad, Jebbink Maarten F., Deijs Martin, Canuti Marta, van Dort Karel A., Bakker Margreet, Grady Bart P. X., Prins Maria, van Hemert Formijn J., Kootstra Neeltje A., van der Hoek Lia Identification of a new genotype of Torque Teno Mini virus Virology journal 2013;10 (1):323 [PubMed]

2012

• Cobos Jiménez Viviana, Booiman Thijs, de Taeye Steven W., van Dort Karel A., Rits Maarten A. N., Hamann Jörg, Kootstra Neeltje A. Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons Scientific reports 2012;2:763 [PubMed]
• Zoughlami Younes, Voermans Carlijn, Brussen Kim, van Dort Karel A., Kootstra Neeltje A., Maussang David, Smit Martine J., Hordijk Peter L., van Hennik Paula B. Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection Blood 2012;119 (9):2024-2032 [PubMed]

2011

• Edo-Matas Diana, van Dort Karel A., Setiawan Laurentia C., Schuitemaker Hanneke, Kootstra Neeltje A. Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants Virology 2011;412 (2):269-277 [PubMed]
• Bol Sebastiaan M., Booiman Thijs, Bunnik Evelien M., Moerland Perry D., van Dort Karel, Strauss Jerome F., Sieberer Margit, Schuitemaker Hanneke, Kootstra Neeltje A., van 't Wout Angélique B. Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages Virology 2011;420 (1):32-42 [PubMed]

2008

• Rits Maarten A. N., van Dort Karel A., Kootstra Neeltje A. Polymorphisms in the Regulatory Region of the Cyclophilin A Gene Influence the Susceptibility for HIV-1 Infection PLoS ONE 2008;3 (12):e3975 [PubMed]
• van Manen Daniëlle, Rits Maarten A. N., Beugeling Corrine, van Dort Karel, Schuitemaker Hanneke, Kootstra Neeltje A. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection PLoS pathogens 2008;4 (2):e18 [PubMed]
• Piriou Erwan, van Dort Karel, Otto Sigrid, van Oers Marinus H. J., van Baarle Debbie Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection Clinical infectious diseases 2008;46 (2):313-316 [PubMed]

2007

• Rits Maarten A. N., van Dort Karel A., Münk Carsten, Meijer Alexander B., Kootstra Neeltje A. Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein Molecular therapy 2007;15 (5):930-937 [PubMed]
• Kootstra Neeltje A., Navis Marjon, Beugeling Corrine, van Dort Karel A., Schuitemaker Hanneke The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase AIDS (London, England) 2007;21 (15):2015-2023 [PubMed]

2006

• Piriou Erwan R. W. A. N., van Dort Karel, Weel Jan F. L., Bemelman Frederike J., Gamadia Laila E., van Oers Marinus H. J., van Baarle Debbie Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient Clinical immunology (Orlando, Fla.) 2006;119 (1):16-20 [PubMed]
• Jansen Christine A., Piriou Erwan, de Cuyper Iris M., van Dort Karel, Lange Joep M. A., Miedema Frank, van Baarle Debbie Long-term highly active antiretroviral therapy in chronic HIV-1 infection: evidence for reconstitution of antiviral immunity Antiviral therapy 2006;11 (1):105-116 [PubMed]

2005

• Piriou Erwan, van Dort Karel, Nanlohy Nening M., van Oers Marinus H. J., Miedema Frank, van Baarle Debbie Loss of EBNA1-specific memory CD4(+) and CD8(+) T cells in HIV-infected patients progressing to AIDS-related non-hodgkin lymphoma Blood 2005;106 (9):3166-3174 [PubMed]
• Piriou Erwan R., van Dort Karel, Nanlohy Nening M., van Oers Marinus H., Miedema Frank, van Baarle Debbie Novel method for detection of virus-specific CD41+ T cells indicates a decreased EBV-specific CD4+ T cell response in untreated HIV-infected subjects European journal of immunology 2005;35 (3):796-805 [PubMed]
• Piriou Erwan, Jansen Christine A., van Dort Karel, de Cuyper Iris, Nanlohy Nening M., Lange Joep M. A., van Oers Marinus H. J., Miedema Frank, van Baarle Debbie Reconstitution of EBV latent but not lytic antigen-specific CD4(+) and CD8(+) T cells after HIV treatment with highly active antiretroviral therapy Journal of immunology (Baltimore, Md. 2005;175 (3):2010-2017 [PubMed]

2004

• Piriou Erwan R., van Dort Karel, Nanlohy Nening M., Miedema Frank, van Oers Marinus H., van Baarle Debbie Altered EBV viral load setpoint after HIV seroconversion is in accordance with lack of predictive value of EBV load for the occurrence of AIDS-related non-Hodgkin lymphoma Journal of immunology (Baltimore, Md. 2004;172 (11):6931-6937 [PubMed]