L.J. Valentijn PhD publications

foto

Publications PhD L.J. Valentijn

Position
Assistant Professor
Main activities
Research, Other
Specialisation
Molecular Biology/Oncology
Focus of research
MYCN pathway and genomic aberrations in neuroblastoma

Neuroblastoma is an embryonic tumor derived from the peripheral nervous system. Neuroblastoma is highly heterogeneous in histology, molecular biology and outcome. Genomic aberrations that exist of whole chromosome gains and losses are found in favorable tumors. MYCN (chromosome 2p) is amplified in 20% of neuroblastoma tumors and these tumors follow a particular aggressive course. Other frequent events involve chromosome 1p, 11q and 17q. Interestingly, loss of chromosome 1p and gain of 17q frequently occur in tumors with MYCN amplification.
Previously, we silenced MYCN in a MYCN-amplified cell line, measured expression changes (Affymetrix Array profiling) and integrated these data with neuroblastoma tumors . This resulted in a mycn-157 signature that predicts poor clinical outcome of neuroblastoma patients with and without MYCN amplification. Tissue array analysis of MYCN protein showed that the latter group has increased MYCN protein expression in tumor cells.
Currently we are investigating the involvement of other chromosomal aberrations that occur in neuroblastoma tumors. Using complete genomic sequencing data we can exactly determine the break point regions and identify mutated genes. Silencing (shRNA) and induction of candidate genes in neuroblastoma cell lines will identify genes involved in neuroblastoma development and MYCN stability.

Amsterdam UMC Research Institutes
AMC departments
All publications

2019

  • van Groningen Tim, Akogul Nurdan, Westerhout Ellen M., Chan Alvin, Hasselt Nancy E., Zwijnenburg Danny A., Broekmans Marloes, Stroeken Peter, Haneveld Franciska, Hooijer Gerrit K. J., Savci-Heijink C. Dilara, Lakeman Arjan, Volckmann Richard, van Sluis Peter, Valentijn Linda J., Koster Jan, Versteeg Rogier, van Nes Johan A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma Nature communications 2019;10 (1):1530 [PubMed]

2017

  • van Groningen Tim, Koster Jan, Valentijn Linda J., Zwijnenburg Danny A., Akogul Nurdan, Hasselt Nancy E., Broekmans Marloes, Haneveld Franciska, Nowakowska Natalia E., Bras Johannes, van Noesel Carel J. M., Jongejan Aldo, van Kampen Antoine H., Koster Linda, Baas Frank, van Dijk-Kerkhoven Lianne, Huizer-Smit Margriet, Lecca Maria C., Chan Alvin, Lakeman Arjan, Molenaar Piet, Volckmann Richard, Westerhout Ellen M., Hamdi Mohamed, van Sluis Peter G., Ebus Marli E., Molenaar Jan J., Tytgat Godelieve A., Westerman Bart A., van Nes Johan, Versteeg Rogier Neuroblastoma is composed of two super-enhancer-associated differentiation states Nature genetics 2017;49 (8):1261-1266 [PubMed]

2016

  • Eberhardt Allison, Hansen Jeanne N., Koster Jan, Lotta Louis T., Wang Simeng, Livingstone Emmett, Qian Kun, Valentijn Linda J., Zheng Yujun George, Schor Nina F., Li Xingguo Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma Oncotarget 2016;7 (39):63629-63639 [PubMed]

2015

  • Mandriota Stefano J., Valentijn Linda J., Lesne Laurence, Betts David R., Marino Denis, Boudal-Khoshbeen Mary, London Wendy B., Rougemont Anne-Laure, Attiyeh Edward F., Maris John M., Hogarty Michael D., Koster Jan, Molenaar Jan J., Versteeg Rogier, Ansari Marc, Gumy-Pause Fabienne Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism Oncotarget 2015;6 (21):18558-18576 [PubMed]
  • Valentijn Linda J., Koster Jan, Zwijnenburg Danny A., Hasselt Nancy E., van Sluis Peter, Volckmann Richard, van Noesel Max M., George Rani E., Tytgat Godelieve A. M., Molenaar Jan J., Versteeg Rogier TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors Nature genetics 2015;47 (12):1411-+ [PubMed]

2012

  • Tonelli Roberto, McIntyre Alan, Camerin Consuelo, Walters Zoë S., Di Leo Korinne, Selfe Joanna, Purgato Stefania, Missiaglia Edoardo, Tortori Andrea, Renshaw Jane, Astolfi Annalisa, Taylor Kathryn R., Serravalle Salvatore, Bishop Ryan, Nanni Cristina, Valentijn Linda J., Faccini Andrea, Leuschner Ivo, Formica Serena, Reis-Filho Jorge S., Ambrosini Valentina, Thway Khin, Franzoni Monica, Summersgill Brenda, Marchelli Rosangela, Hrelia Patrizia, Cantelli-Forti Giorgio, Fanti Stefano, Corradini Roberto, Pession Andrea, Shipley Janet Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy Clinical cancer research 2012;18 (3):796-807 [PubMed]
  • Valentijn Linda J., Koster Jan, Haneveld Franciska, Aissa Rachida Ait, van Sluis Peter, Broekmans Marloes E. C., Molenaar Jan J., van Nes Johan, Versteeg Rogier Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification Proceedings of the National Academy of Sciences of the United States of America 2012;109 (47):19190-19195 [PubMed]
  • Molenaar Jan J., Domingo-Fernández Raquel, Ebus Marli E., Lindner Sven, Koster Jan, Drabek Ksenija, Mestdagh Pieter, van Sluis Peter, Valentijn Linda J., van Nes Johan, Broekmans Marloes, Haneveld Franciska, Volckmann Richard, Bray Isabella, Heukamp Lukas, Sprüssel Annika, Thor Theresa, Kieckbusch Kristina, Klein-Hitpass Ludger, Fischer Matthias, Vandesompele Jo, Schramm Alexander, van Noesel Max M., Varesio Luigi, Speleman Frank, Eggert Angelika, Stallings Raymond L., Caron Huib N., Versteeg Rogier, Schulte Johannes H. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression Nature genetics 2012;44 (11):1199-1206 [PubMed]
  • Molenaar Jan J., Koster Jan, Zwijnenburg Danny A., van Sluis Peter, Valentijn Linda J., van der Ploeg Ida, Hamdi Mohamed, van Nes Johan, Westerman Bart A., van Arkel Jennemiek, Ebus Marli E., Haneveld Franciska, Lakeman Arjan, Schild Linda, Molenaar Piet, Stroeken Peter, van Noesel Max M., Ora Ingrid, Santo Evan E., Caron Huib N., Westerhout Ellen M., Versteeg Rogier Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes Nature 2012;483 (7391):589-U107 [PubMed]

2009

  • Molenaar Jan J., Ebus Marli E., Geerts Dirk, Koster Jan, Lamers Fieke, Valentijn Linda J., Westerhout Ellen M., Versteeg Rogier, Caron Huib N. Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells Proceedings of the National Academy of Sciences of the United States of America 2009;106 (31):12968-12973 [PubMed]

2008

  • Koppen Arjen, Ait-Aissa Rachida, Koster Jan, Øra Ingrid, Bras Johannes, van Sluis Peter G., Caron Huib, Versteeg Rogier, Valentijn Linda J. Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN International journal of cancer. Journal international du cancer 2008;122 (7):1455-1464 [PubMed]
  • Koppen Arjen Gene regulation by MYCN in neuroblastoma 2008. 152p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Versteeg R.; Co-supervisor: Valentijn L. J.)

2007

  • Koppen Arjen, Ait-Aissa Rachida, Hopman Saskia, Koster Jan, Haneveld Franciska, Versteeg Rogier, Valentijn Linda J. Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation Cancer letters 2007;256 (2):218-228 [PubMed]
  • Koppen Arjen, Ait-Aissa Rachida, Koster Jan, van Sluis Peter G., Ora Ingrid, Caron Huib N., Volckmann Richard, Versteeg Rogier, Valentijn Linda J. Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma European journal of cancer (Oxford, England 2007;43 (16):2413-2422 [PubMed]

2006

  • Valentijn Linda J., Koster Jan, Versteeg Rogier Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV Genomics 2006;87 (4):483-489 [PubMed]

2005

  • Schaaf Gerben J., Ruijter Jan M., van Ruissen Fred, Zwijnenburg Danny A., Waaijer Raymond, Valentijn Linda J., Benit-Deekman Jennifer, van Kampen Antoine H. C., Baas Frank, Kool Marcel Full transcriptome analysis of rhabdomyosarcoma, normal, and fetal skeletal muscle: statistical comparison of multiple SAGE libraries FASEB journal 2005;19 (3):404-406 [PubMed]
  • Valentijn Linda J., Koppen Arjen, van Asperen Ronald, Root Heather A., Haneveld Franciska, Versteeg Rogier Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes Cancer research 2005;65 (8):3136-3145 [PubMed]

1998

  • Valentijn L. J., Baas F. Genetic basis of peripheral neuropathies Progress in brain research 1998;117:249-264 [PubMed]
  • Lenssen P. P., Gabreëls-Festen A. A., Valentijn L. J., Jongen P. J., van Beersum S. E., van Engelen B. G., van Wensen P. J., Bolhuis P. A., Gabreëls F. J., Mariman E. C. Hereditary neuropathy with liability to pressure palsies. Phenotypic differences between patients with the common deletion and a PMP22 frame shift mutation Brain 1998;121 (8):1451-1458 [PubMed]

1997

  • Visser M., Sijmons C., Bras J., Arceci R. J., Godfried M., Valentijn L. J., Voûte P. A., Baas F. Allelotype of pediatric rhabdomyosarcoma Oncogene 1997;15 (11):1309-1314 [PubMed]

1996

  • Piosik P. A., van Groenigen M., Ponne N. J., Valentijn L. J., Bolhuis P. A., Baas F. Caprine homologue of rodent 5'-AMP-activated protein kinase subunit and yeast SNF4/CAT3 is down-regulated by thyroid hormone MOLECULAR BRAIN RESEARCH 1996;40 (2):240-253 [PubMed]

1995

  • Gabreëls-Festen A. A., Bolhuis P. A., Hoogendijk J. E., Valentijn L. J., Eshuis E. J., Gabreëls F. J. Charcot-Marie-Tooth disease type 1A: morphological phenotype of the 17p duplication versus PMP22 point mutations Acta neuropathologica 1995;90 (6):645-649 [PubMed]
  • Valentijn L. J., Ouvrier R. A., van den Bosch N. H., Bolhuis P. A., Baas F., Nicholson G. A. Déjérine-Sottas neuropathy is associated with a de novo PMP22 mutation Human mutation 1995;5 (1):76-80 [PubMed]

1994

  • Nicholson G. A., Valentijn L. J., Cherryson A. K., Kennerson M. L., Bragg T. L., DeKroon R. M., Ross D. A., Pollard J. D., McLeod J. G., Bolhuis P. A., Baas F. A frame shift mutation in the PMP22 gene in hereditary neuropathy with liability to pressure palsies Nature genetics 1994;6 (3):263-266 [PubMed]
  • Mariman E. C., Gabreëls-Festen A. A., van Beersum S. E., Valentijn L. J., Baas F., Bolhuis P. A., Jongen P. J., Ropers H. H., Gabreëls F. J. Prevalence of the 1.5-Mb 17p deletion in families with hereditary neuropathy with liability to pressure palsies Annals of neurology 1994;36 (4):650-655 [PubMed]

1993

  • Hoogendijk J. E., Janssen E. A., Gabreëls-Festen A. A., Hensels G. W., Joosten E. M., Gabreëls F. J., Zorn I., Valentijn L. J., Baas F., Ongerboer de Visser B. W. Allelic heterogeneity in hereditary motor and sensory neuropathy type Ia (Charcot-Marie-Tooth disease type 1a) Neurology 1993;43 (5):1010-1015 [PubMed]
  • Valentijn L. J., Baas F., Zorn I., Hensels G. W., de Visser M., Bolhuis P. A. Alternatively sized duplication in Charcot-Marie-Tooth disease type 1A Human molecular genetics 1993;2 (12):2143-2146 [PubMed]
  • Kulkens T., Bolhuis P. A., Wolterman R. A., Kemp S., te Nijenhuis S., Valentijn L. J., Hensels G. W., Jennekens F. G., de Visser M., Hoogendijk J. E., Baas F. Deletion of the serine 34 codon from the major peripheral myelin protein P0 gene in Charcot-Marie-Tooth disease type 1B Nature genetics 1993;5 (1):35-39 [PubMed]
  • van Groenigen M., Valentijn L. J., Baas F. Identification of a functional initiator sequence in the human MDR1 promoter BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1993;1172 (1-2):138-146 [PubMed]
  • Hensels G. W., Janssen E. A., Hoogendijk J. E., Valentijn L. J., Baas F., Bolhuis P. A. Quantitative measurement of duplicated DNA as a diagnostic test for Charcot-Marie-Tooth disease type 1a Clinical chemistry 1993;39 (9):1845-1849 [PubMed]

1992

  • Hoogendijk J. E., Hensels G. W., Gabreëls-Festen A. A., Gabreëls F. J., Janssen E. A., de Jonghe P., Martin J. J., van Broeckhoven C., Valentijn L. J., Baas F. De-novo mutation in hereditary motor and sensory neuropathy type I Lancet 1992;339 (8801):1081-1082 [PubMed]
  • Valentijn L. J., Baas F., Wolterman R. A., Hoogendijk J. E., van den Bosch N. H., Zorn I., Gabreëls-Festen A. W., de Visser M., Bolhuis P. A. Identical point mutations of PMP-22 in Trembler-J mouse and Charcot-Marie-Tooth disease type 1A Nature genetics 1992;2 (4):288-291 [PubMed]
  • Valentijn L. J., Bolhuis P. A., Zorn I., Hoogendijk J. E., van den Bosch N., Hensels G. W., Stanton V. P., Housman D. E., Fischbeck K. H., Ross D. A., Nicholson G. A., Meershoek E. J., Dauwerse H. G., van Ommen G. J. B., Baas F. The peripheral myelin gene PMP-22/GAS-3 is duplicated in Charcot-Marie-Tooth disease type 1A Nature genetics 1992;1 (3):166-170 [PubMed]
back to PhD L.J. Valentijn