- van der Veen S. J., van Kuilenburg A. B. P., Hollak C. E. M., Kaijen P. H. P., Voorberg J., Langeveld M. Antibodies against recombinant alpha-galactosidase A in Fabry disease: Subclass analysis and impact on response to treatment Molecular genetics and metabolism 2019;126 (2):162-168 [PubMed]
- Körver Simon, Geurtsen Gert J., Hollak Carla E. M., van Schaik Ivo N., Longo Maria G. F., Lima Marjana R., Vedolin Leonardo, Dijkgraaf Marcel G. W., Langeveld Mirjam Predictors of objective cognitive impairment and subjective cognitive complaints in patients with Fabry disease Scientific reports 2019;9 (1) [PubMed]
- Langeveld M., Hollak C. E. M. Bone health in patients with inborn errors of metabolism Reviews in endocrine & metabolic disorders 2018;19 (1):81-92 [PubMed]
- Oussoren Esmee, Mathijssen Irene M. J., Wagenmakers Margreet, Verdijk Rob M., Bredero-Boelhouwer Hansje H., van Veelen-Vincent Marie-Lise C., van der Meijden Jan C., van den Hout Johanna M. P., Ruijter George J. G., van der Ploeg Ans T., Langeveld Mirjam Craniosynostosis affects the majority of mucopolysaccharidosis patients and can contribute to increased intracranial pressure Journal of inherited metabolic disease 2018;41 (6):1247-1258 [PubMed]
- Oussoren Esmee, van Eerd David, Murphy Elaine, Lachmann Robin, van der Meijden Jan C., Hoefsloot Lies H., Verdijk Rob, Ruijter George J. G., Maas Mario, Hollak Carla E. M., Langendonk Janneke G., van der Ploeg Ans T., Langeveld Mirjam Mucolipidosis type III, a series of adult patients Journal of inherited metabolic disease 2018;41 (5):839-848 [PubMed]
Personal information
Family name, First name: Langeveld, Mirjam
Researcher unique identifier(s): https://orcid.org/0000-0002-9934-6831
Date of birth: 18-12-1977
Nationality: Dutch
URL for web site: https://www.amc.nl/web/specialismen/expertisecentra/sphinx-1.htm https://investof.nl/home/
Education, current and previous positions
January 2017-current
Internist endocrinologist-specialist for adults with inherited metabolic disorders, Amsterdam UMC, location AMC, Amsterdam
Principle Investigator
September 2014-December 2016
Internist endocrinologist-specialist for adults with inherited metabolic disorders, Erasmus Medical Center, Rotterdam
March 2013-December 2014
Honorary clinical fellowship, Institute of Metabolic Science, University of Cambridge (part-time)
(Pre)clinical research on adaptive thermogenesis and body weight regulation
September 2012 –August 2014
Fellowship Endocrinology, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam
April 2010 – April 2011
Postdoctoral research associate, Institute of Metabolic Science, University of Cambridge
(Pre)clinical research on adaptive thermogenesis and body weight regulation
October 2005 – August 2012
Clinical internship, Department of Internal Medicine, Academic Medical Center, University of Amsterdam
April 2004 – April 2009
PhD, Department of Medical Biochemistry and Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam
Research on the role of glycosphingolipids in metabolism
Promotors: prof Carla Hollak (AMC, department of Endocrinology and Metabolism) and prof Hans Aerts (AMC, department of Biochemistry)
February 2001 – January 2002
Research internship at the department of Experimental Immunology, Academic Medical Center, University of Amsterdam
Phenotypic analysis of splenic T cells
September 1997 – April 2004
MD, Academic Medical Center, University of Amsterdam
September 1996 – March 1999
Medical biology, University of Amsterdam
Fellowships and awards
-EFSD Albert Renold Travel Fellowship, 2013
-Marie Curie Intra-European Fellowship (KP7), 2010
-Oral presentation award, European Study Group on Lysosomal Disease, 2009
-Poster award, European Working Group on Gaucher Disease, 2008
Supervision of graduate students and postdoctoral fellows
Supervision of PhD students (copromotor):
- Esmee Oussoren, research on skeletal complications in mucopolysaccharidoses and mucolipidoses, PhD defence November 2018, Erasmus MC
- Simon Korver, research on neuropsychological aspects of Fabry disease, PhD defence expected January 2020, Amsterdam UMC
- Sanne van der Veen, research on the antibody response against enzyme replacement therapy in Fabry disease, started PhD project in 2017, Amsterdam UMC
- Mohamed El Sayed, started his PhD project in 2018, research on cardiac complications of Fabry disease, Amsterdam UMC
- Elise Termeulen, started her PhD project in 2019, research on advanced diagnositics for inborn errors of metabolism, Amsterdam UMC
- Loek Crefcoeur, research on primary carnitine deficiency, started his PhD project in 2018, UMC Utrecht and Amsterdam UMC
Teaching activities
Over the past ten years I have been involved in the teaching medical students (lectures workshop) in the field of nutrition as well as inborn errors of metabolism. In addition, I have organised and been involved in tuition of internists, psychiatrists and neurologist on the topic of inborn errors of metabolism. I’m part of an international collaboration dedicated to developing international education and training for clinicians involved in care for adult patients with inborn errors of metabolism.
Organisation of scientific meetings
As secretary of the adult committee of the Society for Inborn Errors of Metabolism I organise scientific sessions at the yearly SSIEM international conference.
Involvement in international drug trials
Principal investigator at the AMC of two international industry initiated treatment trials in Fabry disease:
F20-Study of the Safety and Efficacy of PRX-102 Compared to Agalsidase Beta on Renal Function (BALANCE)
F30- Extension Study of 1 mg/mL Pegunigalsidase Alfa in Patients With Fabry Disease (BRIDGE)
Memberships of scientific societies
European Fabry Working Group (EFWG)
Society for the Study of Inborn Errors of Metabolism (SSIEM); Secretary of the adult committee
Erfelijke Stofwisselingsziekten Nederland (ESN)
Internisten voor Volwassenen met een Erfelijke Stofwisselingsziekten (INVEST)
Prof. PhD C.E.M. Hollak (Natural history, pathophysiology and treatment of lysosomal storage disorders and regulatory science of orphan drugs)
- IQVIA RDS Netherlands B.V.
- Nederlandse Internisten Vereniging
- Protalix Ltd.
- RIVM