
Publications MD PhD P.J. Hajenius
- Position
- Medical Specialist
- Main activities
- Patient care, Research
- Specialisation
- Gynecologist, perinatologist
- Focus of research
Early pregnancy complications (miscarriage, ectopic pregnancy)
Preterm birth
Quality of care
Amsterdam UMC Research Institutes
AMC departments
All publications
2019
- van den Berg Merel M. J., Hajenius Petra J., Mol Femke, Hermens Rosella P. M. G., van der Veen Fulco, Goddijn Mariette, van den Boogaard Emmy Guideline-based quality indicators for early pregnancy assessment units Reproductive biomedicine online 2019:7 [PubMed]
- Peelen Myrthe J. CS., Luef Birgitte M. ller, Lamont Ronald F., de Milliano Inge, Jensen J. rgen Skov, Limpens Jacqueline, Hajenius Petra J., Jørgensen Jan Stener, Menon Ramkumar The influence of the vaginal microbiota on preterm birth: A systematic review and recommendations for a minimum dataset for future research Placenta 2019;79:30-39 [PubMed]
2018
- van den Berg M. M. J., Dancet E. A. F., Erlikh T., van der Veen F., Goddijn M., Hajenius P. J. Patient-centered early pregnancy care: a systematic review of quantitative and qualitative studies on the perspectives of women and their partners Human reproduction update 2018;24 (1):106-118 [PubMed]
2016
- Peelen Myrthe J. C. S., Kazemier Brenda M., Ravelli Anita C. J., de Groot Christianne J. M., van der Post Joris A. M., Mol Ben W. J., Hajenius Petra J., Kok Marjolein Impact of fetal gender on the risk of preterm birth, a national cohort study Acta obstetricia et gynecologica Scandinavica 2016;95 (9):1034-1041 [PubMed]
- Peelen Myrthe J., Sheikh Aziz, Kok Marjolein, Hajenius Petra, Zimmermann Luc J., Kramer Boris W., Hukkelhoven Chantal W., Reiss Irwin K., Mol Ben W., Been Jasper V. Tobacco control policies and perinatal health: a national quasi-experimental study Scientific reports 2016;6:23907 [PubMed]
2015
- Mol F., van Mello N. M., Strandell A., Jurkovic D., Ross J. A., Yalcinkaya T. M., Barnhart K. T., Verhoeve H. R., Graziosi G. C., Koks C. A., Mol B. W., Ankum W. M., van der Veen F., Hajenius P. J., van Wely M., Janssen Ineke C. A. H., Kragt Harry, Hoek Annemieke, Trimbos-Kemper Trudy C. M., Broekmans Frank J. M., Willemsen Wim N. P., Dijkman A. B., Thurkow A. L., van Dessel H. J. H. M., van der Linden P. J. Q., Bouwmeester F. W., Oosterhuis G. J. E., van Beek J. J., Emanuel M. H., Visser H., Doornbos J. P. R., Pernet P. J. M., Friederich J., Strandell Karin, Hogström Lars, Klinte Ingmar, Pettersson F., Sabetirad Z., Nilsson K., Tegerstedt G., Platz-Christensen J. J. Cost-effectiveness of salpingotomy and salpingectomy in women with tubal pregnancy (a randomized controlled trial) Human reproduction (Oxford, England) 2015;30 (9):2038-2047 [PubMed]
- van den Berg Merel M. J., Goddijn Mariette, Ankum Willem M., van Woerden Emmy E., van der Veen Fulco, van Wely Madelon, Hajenius Petra J. Early pregnancy care over time: should we promote an early pregnancy assessment unit? Reproductive biomedicine online 2015;31 (2):192-198 [PubMed]
- Freeman Liv M., Bloemenkamp Kitty W., Franssen Maureen T., Papatsonis Dimitri N., Hajenius Petra J., Hollmann Markus W., Woiski Mallory D., Porath Martina, van den Berg Hans J., van Beek Erik, Borchert Odette W. H. M., Schuitemaker Nico, Sikkema J. Marko, Kuipers A. H. M., Logtenberg Sabine L. M., van der Salm Paulien C. M., Oude Rengerink Katrien, Lopriore Enrico, van den Akker-van Marle M. Elske, le Cessie Saskia, van Lith Jan M., Struys Michel M., Mol Ben Willem J., Dahan Albert, Middeldorp Johanna M. Patient controlled analgesia with remifentanil versus epidural analgesia in labour: randomised multicentre equivalence trial BMJ (Clinical research ed.) 2015;350:h846 [PubMed]
- van Baaren Gert J., Peelen Myrthe J. C. S., Schuit Ewoud, van der Post Joris A. M., Mol Ben W. J., Kok Marjolein, Hajenius Petra J. Preterm birth in singleton and multiple pregnancies: evaluation of costs and perinatal outcomes European journal of obstetrics, gynecology, and reproductive biology 2015;186:34-41 [PubMed]
- van Mello Norah M., Mol Femke, Hajenius Petra J., Ankum Willem M., Mol Ben Willem, van der Veen Fulco, van Wely Madelon Randomized comparison of health-related quality of life in women with ectopic pregnancy or pregnancy of unknown location treated with systemic methotrexate or expectant management European journal of obstetrics, gynecology, and reproductive biology 2015;192:1-5 [PubMed]
2014
- Mol Femke, van Mello Norah M., Strandell Annika, Strandell Karin, Jurkovic Davor, Ross Jackie, Barnhart Kurt T., Yalcinkaya Tamer M., Verhoeve Harold R., Graziosi Giuseppe C. M., Koks Carolien A. M., Klinte Ingmar, Hogström Lars, Janssen Ineke C. A. H., Kragt Harry, Hoek Annemieke, Trimbos-Kemper Trudy C. M., Broekmans Frank J. M., Willemsen Wim N. P., Ankum Willem M., Mol Ben W., van Wely Madelon, van der Veen Fulco, Hajenius Petra J., Dijkman A. B., Thurkow A. L., van Dessel H. J. H. M., van der Linden P. J. Q., Bouwmeester F. W., Oosterhuis G. J. E., van Beek J. J., Emanuel M. H., Visser H., Doornbos J. P. R., Pernet P. J. M., Friederich J., Pettersson F., Sabetirad Z., Nilsson K., Tegerstedt G., Platz-Christensen J. J. Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial Lancet 2014;383 (9927):1483-1489 [PubMed]
2013
- van Mello N. M., Mol F., Verhoeve H. R., van Wely M., Adriaanse A. H., Boss E. A., Dijkman A. B., Bayram N., Emanuel M. H., Friederich J., van der Leeuw-Harmsen L., Lips J. P., van Kessel M. A., Ankum W. M., van der Veen F., Mol B. W., Hajenius P. J. Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison Human reproduction (Oxford, England) 2013;28 (1):60-67 [PubMed]
- van Mello Norah M. Non-invasive diagnosis and management of ectopic pregnancy 2013. 183p. ISBN 9789461823373. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Mol B. W. J., van der Veen F.; Co-supervisors: Hajenius P. J., Ankum W. M.)
- Mol Femke Surgical management of tubal pregnancy 2013. 183p. ISBN 9789461823410. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van der Veen F., Mol B. W. J.; Co-supervisors: Hajenius P. J., Ankum W. M.)
- Verschoor Marianne A. C., Lemmers Marike, Bossuyt Patrick M., Graziosi Giuseppe C. M., Hajenius Petra J., Hendriks Dave J., van Hooff Marcel A. H., van Meurs Hannah S., Opmeer Brent C., van Tulder Maurits W., Bouwma Liesanne, Catshoek Ruby, Geomini Peggy, Klinkert Ellen R., Langenveld Josje, Nieboer Theodoor E., van der Ploeg J. Marinus, Radder Celine M., Spinder Taeke, van der Voet Lucy F., Mol Ben Willem J., Huirne Judith A. F., Ankum Willem M. Surgical versus expectant management in women with an incomplete evacuation of the uterus after treatment with misoprostol for miscarriage: the MisoREST trial BMC pregnancy and childbirth 2013;13 (1):102 [PubMed]
2012
- van Mello N. M., Mol F., Opmeer B. C., Ankum W. M., Barnhart K., Coomarasamy A., Mol B. W., van der Veen F., Hajenius P. J. Diagnostic value of serum hCG on the outcome of pregnancy of unknown location: a systematic review and meta-analysis Human reproduction update 2012;18 (6):603-617 [PubMed]
- van Mello Norah M., Mol Femke, Ankum Willem M., Mol Ben Willem, van der Veen Fulco, Hajenius Petra J. Ectopic pregnancy: how the diagnostic and therapeutic management has changed Fertility and sterility 2012;98 (5):1066-1073 [PubMed]
- Freeman Liv M., Bloemenkamp Kitty W. M., Franssen Maureen T. M., Papatsonis Dimitri N. M., Hajenius Petra J., van Huizen Marloes E., Bremer Henk A., van den Akker Eline S. A., Woiski Mallory D., Porath Martina M., van Beek Erik, Schuitemaker Nico, van der Salm Paulien C. M., Fong Bianca F., Radder Celine, Bax Caroline J., Sikkema Marko, van den Akker-van Marle M. Elske, van Lith Jan M. M., Lopriore Enrico, Uildriks Renske J., Struys Michel M. R. F., Mol Ben Willem J., Dahan Albert, Middeldorp Johanna M. Remifentanil patient controlled analgesia versus epidural analgesia in labour. A multicentre randomized controlled trial BMC pregnancy and childbirth 2012;12 (1):63 [PubMed]
- van Mello Norah M., Zietse Carlijn S., Mol Femke, Zwart Joost J., van Roosmalen Jos, Bloemenkamp Kitty W., Ankum Willem M., van der Veen Fulco, Mol Ben Willem J., Hajenius Petra J. Severe maternal morbidity in ectopic pregnancy is not associated with maternal factors but may be associated with quality of care Fertility and sterility 2012;97 (3):623-629 [PubMed]
2011
- Mol F., van den Boogaard E., van Mello N. M., van der Veen F., Mol B. W., Ankum W. M., van Zonneveld P., Dijkman A. B., Verhoeve H. R., Mozes A., Goddijn M., Hajenius P. J. Guideline adherence in ectopic pregnancy management Human reproduction (Oxford, England) 2011;26 (2):307-315 [PubMed]
- Barnhart Kurt, van Mello Norah M., Bourne Tom, Kirk Emma, van Calster Ben, Bottomley Cecilia, Chung Karine, Condous George, Goldstein Steven, Hajenius Petra J., Mol Ben Willem, Molinaro Thomas, O'Flynn O'Brien Katherine L., Husicka Richard, Sammel Mary, Timmerman Dirk Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome Fertility and sterility 2011;95 (3):857-866 [PubMed]
- Hajenius P. J. Vaginaal bloedverlies in de eerste helft van de zwangerschapin: M. J. Heineman, editors. Probleemgeoriënteerd denken in de gynaecologie, obstetrie en voorplantingsgeneeskunde. Utrecht: De Tijdstroom; 2011. p. 339, ISBN 9789058982018
2010
- Mol Femke, van Mello Norah M., Mol Ben W., van der Veen F., Ankum Willem M., Hajenius Petra J. Ectopic pregnancy and pelvic inflammatory disease: a renewed epidemic? European journal of obstetrics, gynecology, and reproductive biology 2010;151 (2):163-167 [PubMed]
- van Mello N. M., Mol F., Opmeer B. C., de Bekker-Grob E. W., Essink-Bot M. L., Ankum W. M., Mol B. W., van der Veen F., Hajenius P. J. Salpingotomy or salpingectomy in tubal ectopic pregnancy: what do women prefer? Reproductive biomedicine online 2010;21 (5):687-693 [PubMed]
2009
- van Mello N. M., Mol F., Mol B. W., Hajenius P. J. Conservative management of tubal ectopic pregnancy Best practice & research. Clinical obstetrics & gynaecology 2009;23 (4):509-518 [PubMed]
- Goddijn M., de Jager F., Kaaijk E. M., van der Veen F., Ankum W. M., Hajenius P. J. Problemen vroeg in de zwangerschap vereisen speciale zorg: 'Jonge zwangerschapsunits' Nederlands tijdschrift voor geneeskunde 2009;153 (45):A601 [PubMed]
- Hajenius P. J. Tubaruptuur bij extra-uteriene graviditeit ondanks dalende HCG Nederlands tijdschrift voor obstetrie & gynaecologie 2009;maart:x
2008
- Mol F., Mol B. W., Ankum W. M., van der Veen F., Hajenius P. J. Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis Human reproduction update 2008;14 (4):309-319 [PubMed]
- Timmerman E., Roovers J. P. W. R., Ankum W. M., Hajenius P. J. De interstitiële graviditeit: niet zomaar een extra-uteriene Nederlands tijdschrift voor geneeskunde 2008;152 (14):787-791 [PubMed]
- Mol Femke, Strandell Annika, Jurkovic Davor, Yalcinkaya Tamer, Verhoeve Harold R., Koks Carolien A. M., van der Linden Paul J. Q., Graziosi Giuseppe C. M., Thurkow Andreas L., Hoek Annemieke, Hogström Lars, Klinte Ingemar, Nilsson Kerstin, van Mello Norah M., Ankum Willem M., van der Veen Fulco, Mol Ben W. M., Hajenius Petra J., Hoek A., Willemsen W. N. P., Trimbos-Kemper G. C. M., van Zonneveld P., Bakkum E. A., Dijkman A. B., Thurkow A. L., van Dessel H. J. H. M., van der Linden P. J. Q., Kragt H., Graziosi C. G. M., Bouwmeester F. W., Oosterhuis G. J. E., Kleiverda G., Spaans W. A., Janssen C. A. H., van Beek J. J., Emanuel M. H., Visser H., Doornbos J. P. R., Pernet P. J. M., Friederich J., Otterlind L., Strandell A., Hogström L., Klinte I., Pettersson F., Sabetirad Z., Nilsson K., Franzén K., Tegerstedt G., Lindahl M. The ESEP study: salpingostomy versus salpingectomy for tubal ectopic pregnancy; the impact on future fertility: a randomised controlled trial BMC Women's health 2008;8 (1):11 [PubMed]
- van Mello Norah M., Mol Femke, Adriaanse Albert H., Boss Erik A., Dijkman Antonius B., Doornbos Johannes P. R., Emanuel Mark Hans, Friederich Jaap, van der Leeuw-Harmsen Loes, Lips Jos P., van Santbrink Evert J. P., Verhoeve Harold R., Visser Harry, Ankum Willem M., van der Veen Fulco, Mol Ben W., Hajenius Petra J. The METEX study: methotrexate versus expectant management in women with ectopic pregnancy: a randomised controlled trial BMC Women's health 2008;8 (1):10 [PubMed]
2007
- Hajenius P. J., Mol F., Mol B. W. J., Bossuyt P. M. M., Ankum W. M., van der Veen F. Interventions for tubal ectopic pregnancy Cochrane database of systematic reviews (Online) 2007;2007 (1):CD000324 [PubMed]
- van Weert J. M., Hajenius P. J., Richard E., Wolf H., Bleker O. P. Late eclampsie post partum Nederlands tijdschrift voor geneeskunde 2007;151 (7):414-417 [PubMed]
2003
- Hajenius P. J., Mol B. W. J., Ankum W. M., van der Veen F. Systemic and Local Therapy of Ectopic Pregnancy (Chptr 37)in: D. Timmerman, J. Deprest, T. Bourne, editors. Ultrasound and endoscopis surgery in obstetrics and gynaecology: a combined approach to diagnosis and treatment. London: Springer-Verlag; 2003. p. 278-292, ISBN 9783540762126
2001
- Engelsbel S., Mol B. W., Hajenius P. J., Ankum W. M., van der Veen F., Hemrika D. J., Bossuyt P. M. Non-invasive management of patients with suspected ectopic pregnancy: a survey among Dutch gynaecologists European journal of obstetrics, gynecology, and reproductive biology 2001;95 (1):81-85 [PubMed]
2000
- Hajenius P. J., Mol B. W., Bossuyt P. M., Ankum W. M., van der Veen F. Interventions for tubal ectopic pregnancy Cochrane database of systematic reviews (Online) 2000;2000 (2):CD000324 [PubMed]
- Mol B. W., Hajenius P. J., van der Veen F. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies New England journal of medicine 2000;342 (15):1138 [PubMed]
1999
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., van der Veen F., Hemrika D. J., Bossuyt P. M. Are gestational age and endometrial thickness alternatives for serum human chorionic gonadotropin as criteria for the diagnosis of ectopic pregnancy? Fertility and sterility 1999;72 (4):643-645 [PubMed]
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., van der Veen F., Hemrika D. J., Bossuyt P. M. Can noninvasive diagnostic tools predict tubal rupture or active bleeding in patients with tubal pregnancy? Fertility and sterility 1999;71 (1):167-173 [PubMed]
- Hajenius P. J., van der Veen F., Ankum W. M. Cervical pregnancy-a conservative stepwise approach Human reproduction (Oxford, England) 1999;14 (10):2677-2678 [PubMed]
- Dias Pereira G., Hajenius P. J., Mol B. W., Ankum W. M., Hemrika D. J., Bossuyt P. M., van der Veen F. Fertility outcome after systemic methotrexate and laparoscopic salpingostomy for tubal pregnancy Lancet 1999;353 (9154):724-725 [PubMed]
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., van der Veen F., Hemrika D. J., Bossuyt P. M. Should patients who are suspected of having an ectopic pregnancy undergo physical examination? Fertility and sterility 1999;71 (1):155-157 [PubMed]
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., Hemrika D. J., van der Veen F., Bossuyt P. M. Treatment of tubal pregnancy in the netherlands: an economic comparison of systemic methotrexate administration and laparoscopic salpingostomy American journal of obstetrics and gynecology 1999;181 (4):945-951 [PubMed]
1998
- Hajenius P. J., Roos D., Ankum W. M., van der Veen F. Are serum human chorionic gonadotropin clearance curves of use in monitoring methotrexate treatment in cervical pregnancy? Fertility and sterility 1998;70 (2):362-365 [PubMed]
- Mol B. W., van der Veen F., Ankum W. M., Hajenius P. J., Bossuyt P. M. Clarification of fertility after tubal surgery for ectopic pregnancy Fertility and sterility 1998;69 (4):790-1; author reply 791-2 [PubMed]
- Mol B. W., Matthijsse H. C., Tinga D. J., Huynh T., Hajenius P. J., Ankum W. M., Bossuyt P. M., van der Veen F. Fertility after conservative and radical surgery for tubal pregnancy Human reproduction (Oxford, England) 1998;13 (7):1804-1809 [PubMed]
- Mol B. W., van der Veen F., Hajenius P. J., Ankum W. M., Bossuyt P. M., Engelsbel S., Hemrika D. J. Sensitivity specificity and likelihood ratios--do they deserve confidence intervals? Fertility and sterility 1998;70 (1):172-174 [PubMed]
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., van der Veen F., Hemrika D. J., Bossuyt P. M. Serum human chorionic gonadotropin measurement in the diagnosis of ectopic pregnancy when transvaginal sonography is inconclusive Fertility and sterility 1998;70 (5):972-981 [PubMed]
- Nieuwkerk P. T., Hajenius P. J., Ankum W. M., van der Veen F., Wijker W., Bossuyt P. M. Systemic methotrexate therapy versus laparoscopic salpingostomy in patients with tubal pregnancy. Part I. Impact on patients' health-related quality of life Fertility and sterility 1998;70 (3):511-517 [PubMed]
- Nieuwkerk P. T., Hajenius P. J., van der Veen F., Ankum W. M., Wijker W., Bossuyt P. M. Systemic methotrexate therapy versus laparoscopic salpingostomy in tubal pregnancy. Part II. Patient preferences for systemic methotrexate Fertility and sterility 1998;70 (3):518-522 [PubMed]
1997
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., van der Veen F., Hemrika D. J., Bossuyt P. M. An economic evaluation of laparoscopy and open surgery in the treatment of tubal pregnancy Acta obstetricia et gynecologica Scandinavica 1997;76 (6):596-600 [PubMed]
- Mol B. W., Hajenius P. J., Ankum W. M., van der Veen F., Bossuyt P. M. Comparative costs of methotrexate and laparoscopic surgery Human reproduction (Oxford, England) 1997;12 (7):1603-1604 [PubMed]
- Mol B. W., Hajenius P. J., Ankum W. M., van der Veen F., Bossuyt P. M. Cut-off level--what do you want it to be? Fertility and sterility 1997;67 (5):980-981 [PubMed]
- Mol B. W., van der Veen F., Hajenius P. J., Engelsbel S., Ankum W. M., Hogerzeil H. V., Hemrika D. J., Bossuyt P. M. Diagnosis of ectopic pregnancy after in vitro fertilization and embryo transfer Fertility and sterility 1997;68 (6):1027-1032 [PubMed]
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., Hemrika D. J., van der Veen F., Bossuyt P. M. Is conservative surgery for tubal pregnancy preferable to salpingectomy? An economic analysis British journal of obstetrics and gynaecology 1997;104 (7):834-839 [PubMed]
- Hajenius P. J., Mel B. W. J., Ankum W. M., van der Veen F. Methotrexate in tubal pregnancy - Reply Lancet 1997;350 (9090):1555-1556
- Hajenius P. J., Engelsbel S., Mol B. W., van der Veen F., Ankum W. M., Bossuyt P. M., Hemrika D. J., Lammes F. B. Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy Lancet 1997;350 (9080):774-779 [PubMed]
- Mol B. W., Hajenius P. J., Ankum W. M., Bossuyt P. M., van der Veen F. Screening for ectopic pregnancy in symptom-free women at increased risk Obstetrics and gynecology 1997;89 (5 Part 1):704-707 [PubMed]
1996
- Mol B. W., Hajenius P. J., Ankum W. M., van der Veen F., Bossuyt P. M. Conservative versus radical surgery for tubal pregnancy Acta obstetricia et gynecologica Scandinavica 1996;75 (9):866-867 [PubMed]
- Mol B. W., Hajenius P. J., Engelsbel S., Ankum W. M., van der Veen F., Bossuyt P. M. Diagnostiek en behandeling van extra-uteriene graviditeit in Nederland Nederlands tijdschrift voor geneeskunde 1996;140 (26):1358-1361 [PubMed]
- Ankum W. M., Hajenius P. J., Schrevel L. S., van der Veen F. Management of suspected ectopic pregnancy. Impact of new diagnostic tools in 686 consecutive cases Journal of reproductive medicine 1996;41 (10):724-728 [PubMed]
- Hajenius P. J., Voigt R. R., Engelsbel S., Mol B. W., Hemrika D. J., van der Veen F. Serum human chorionic gonadotropin clearance curves in patients with interstitial pregnancy treated with systemic methotrexate Fertility and sterility 1996;66 (5):723-728 [PubMed]
1995
- Hajenius P. J., Mol B. W., Ankum W. M., van der Veen F., Bossuyt P. M., Lammes F. B. Clearance curves of serum human chorionic gonadotrophin for the diagnosis of persistent trophoblast Human reproduction (Oxford, England) 1995;10 (3):683-687 [PubMed]
- Ankum W. M., Hajenius P. J. Discriminatory zone for human chorionic gonadotropin--level of certainty? Fertility and sterility 1995;63 (3):683-684 [PubMed]
- Hajenius P. J., Mol B. W., Ankum W. M., van der Veen F., Bossuyt P. M., Lammes F. B. Suspected ectopic pregnancy: expectant management in patients with negative sonographic findings and low serum hCG concentrations Early pregnancy : biology and medicine 1995;1 (4):258-262 [PubMed]
1994
- Hajenius P. J., van Pampus M. G., Ankum W. M. Een zeldzame oorzaak van hypertensie tijdens de zwangerschap met fatale afloop Nederlands tijdschrift voor geneeskunde 1994;138 (5):250-252 [PubMed]