P.J. Koelink PhD

foto

PhD P.J. Koelink

Position
Other Academic Staff
Main activities
Research
Specialisation
gastroentrology
Focus of research

Defective intestinal immunity leading to inflammatory bowel disease and complications (intestinal fibrosis, fatigue, cancer)

Amsterdam UMC Research Institutes
AMC departments
Key publications
All Publications
Curriculum Vitae

Working experience

  • September 2017 - present: Senior post-doc/project manager

Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, AMC, Amsterdam (Dr. Manon Wildenberg).

Collaboration with Glaxo Smith Kline (Stevenage, UK). Subject: Microglia and perivascular macrophages as a target for the treatment of fatigue in inflammatory disorders 

  • April 2013 – august 2017: Senior post-doc/project manager

Tytgat Institute for Liver and Intestinal Research, AMC, Amsterdam (Prof. Dr. Gijs van den Brink) . Collaboration with Janssen Prevention Center, Leiden (Johnson&Johnson, former Crucell).

Subjects:  1) Vaccination strategies in inflammatory bowel disease 2) Vaccine development for microbiome-driven development of colorectal cancer

  • April 2009 – March 2013: Post-doc

            Utrecht University, Faculty of Science, Department Pharmaceutical Sciences, Division of Pharmacology.

            Chemokine receptors in inflammatory diseases (Dr. Aletta D. Kraneveld, Prof.Dr. Gert Folkerts)

  • November 2003 - December 2008: PhD student Leiden University Medical Centre, Department Gastroenterology-Hepatology

 

Education

  *  PhD degree 2010 Leiden University Medical Centre, Department Gastroenterology-Hepatology  (5-ASA – Colorectal Cancer – Cell Death, an intriguing threesome (ISBN 978-90-9024813-4).

  *  Master of Science Biology 2001 Free University of Amsterdam, Faculty of Biology.

  *  Bachelor Life Sciences 1999 Hogeschool Utrecht, Department of Laboratory Science, Utrecht, The Netherlands

 

Publications

  1. Meijer BJ,  Giugliano FP, Baan B, van der Meer JHM, Meisner S, van Roest M, Koelink PJ, de Boer RJ, Jones N, Breitwieser W, van der Wel NN, Wildenberg ME, van den Brink GR, Heijmans J, Muncan V. ATF2 and ATF7 are critical mediators of intestinal epithelial repair. Cellular and Molecular Gastroenterology and Hepatology (accepted).
  2. Koelink PJ, Bloemendaal FM, Li B, Westera L, Vogels EWM, van Roest M, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Te Velde AA, Ponsioen CY, D'Haens GRAM, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling. Gut. 2019 Sep 10.
  3. Bloemendaal FM, Koelink PJ, van Schie KA, Rispens T, Peters CP, Buskens CJ, van der Bilt JD, Bemelman WA, Korf H, Sabino JG, Ponsioen CY, Te Velde AA, D'Haens GRAM, van den Brink GR, Wildenberg ME. TNF-anti-TNF Immune Complexes Inhibit    IL-12/IL-23 Secretion by Inflammatory Macrophages via an Fc-dependent Mechanism. J Crohns Colitis. 2018 May 30
  4. Koelink PJ, Wildenberg ME, Stitt LW,Feagan BG, Koldijk M, van ’t Wout AB, Atreya R, Vieth M, Brands JF, Duijst S, te Velde AA, D’Haens GRAM, Levesque BG, van den Brink GR. Development of reliable, valid and responsive scoring systems for endoscopy and histology in animal models for inflammatory bowel disease. J Crohns Colitis. 2018 Jun 28;12(7):794-803
  5. Bloemendaal FM, Levin AD, Wildenberg ME, Koelink PJ, McRae BL, Salfeld J, Lum J, van der Neut Kolfschoten M, Claassens JW, Visser R, Bentlage A, D’Haens GRAM, Verbeek JS, Vidarsson G, van den Brink GR. Anti-Tumor Necrosis Factor with a Glyco-engineered Fc Region Has Increased Efficacy in Mice with Colitis. Gastroenterology 2017 Nov;153(5):1351-1362.
  6. Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR.  Indian Hedgehog suppresses a stromal cell driven intestinal immune response. Cell Mol Gastroenterol Hepatol. 2017 Sep 5; 5(1): 67-82.
  7. Wildenberg ME, Levin AD, Ceroni A, Huo Z, Koelink PJ, Hakvoort TBM, Westera L, Bloemendaal FM, Brandse JF, Simmons A, D’Haens GRAM, Ebner D, van den Brink GR. Benzimidazoles promote anti-TNF mediated induction of regulatory macrophages and enhance therapeutic efficacy in a murine model. J Crohns Colitis. 2017 Dec 4;11(12):1480-1490.
  8. Wildenberg ME, Koelink PJ, Diederen K, Te Velde AA, Wolfkamp SC, Nuij VJ, Peppelenbosch MP, Nobis M, Sansom OJ, Anderson KI, van der Woude CJ, D'Haens GR, van den Brink GR.The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunol. 2017 Mar;10(2):352-360.
  9. Mcrae BL, Levin AD, Wildenberg ME, Koelink PJ, Bousquet P, Mikaelian I, Schwartz Sterman A, Bryant S, D'Haens G, Kamath R, Salfeld J, van den Brink GR. Fc receptor-mediated effector function contributes to the therapeutic response of anti-TNF monoclonal antibodies in a mouse model of Inflammatory bowel disease. J Crohns Colitis. 2016 Jan;10(1):69-76.
  10. Levin AD, Koelink PJ, Bloemendaal FM, Vos AC, D'Haens GR, van den Brink GR, Wildenberg ME. Autophagy Contributes to the Induction of Anti-TNF Induced Macrophages J Crohns Colitis. 2016 Mar;10(3):323-329. 
  11. Morgan ME, Koelink PJ, Zheng B, van den Brok MHGMH, van de Kant HJG, Verspaget HW, Folkerts G, Adema GJ, Kraneveld AD. TLR6 stimulation promotes Th17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis. Mucosal Immunol 2014 Sep;7(5):1266-77.
  12. Akbari P, Braber S, Gremmels H, Koelink PJ, Verheijden KA, Garssen J, Fink-Gremmels J. Deoxynivalenol: a trigger for intestinal integrity breakdown. FASEB J. 2014 Jun;28(6):2414-29
  13. de Theije CGM, Koelink PJ, Korte-Bouws GAH, Lopes da Silva S, Korte SM, Olivier B, Garssen J, Kraneveld AD. Intestinal inflammation in a murine model of autism spectrum disorders. Brain Behav Immun. 2014 Mar;37:240-7.
  14. de Theije CGM, Wu J, Koelink PJ, Korte-Bouws GAH, Borre Y, Kas MJ, Lopes da Silva S, Korte SM, Olivier B, Garssen J, Kraneveld AD. Autistic-like behavioural and neurochemical changes in a mouse model of food allergy.  Behav Brain Res. 2014 Mar 15;261:265-74.
  15. Borre Y, Panagaki T, Koelink PJ, Morgan ME, Hendriksen H. Garssen J, Kraneveld AD, Olivier B, Oosting RS. Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression. Neuropharmacology 2014 Apr;79:738-49.
  16. Morgan ME, Zheng B, Koelink PJ, van de Kant HJG, Haazen L, van Roest M,  Garssen J, Folkerts G, Kraneveld AD. New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation. PLoS One 2013 Jul 25;8(7):e69936.
  17. Koelink PJ, Overbeek SA, Braber S, Morgan ME, Henricks PAJ, Verspaget HW, Wolfkamp SC, te Velde AA,  Jones CW, Jackson PL, Blalock JE,  Garssen J, Folkerts G, Kraneveld AD. Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Gut 2014 Apr;63(4):578-87.
  18. Overbeek SA, Braber S, Koelink PJ, Henricks PAJ, Mortaz E, LoTam Loi AT, Jackson PL, Garssen J, Wagenaar GTM, Timens W, Koenderman L, Blalock JE, Kraneveld AD, Folkerts G. Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation? Plos one 2013;8(1):e55612.
  19. Hawinkels LJAC, Paauwe M, Verspaget HW, Wiercinska E,  van der Zon JM, van der Ploeg K, Koelink PJ, Lindeman JHN, Mesker W, ten Dijke P, Sier CFM. Interaction with colon cancer cell hyperactivates TGF-β signalling in cancer-asscociated fibroblasts. Oncogene 2014 Jan 2;33(1):97-107
  20. Braber S, Thio M, Blokhuis BR, Henricks PAJ, Koelink PJ, Groot Kormelink T, Bezemer GFG, Kerstjens HAM, Postma DS, Garssen J, Kraneveld AD, Redegeld FA and Folkerts G. An association between neutrophils and immunoglobulin free light chains in the pathogenesis of COPD. American Journal of Respiratory and Critical Care Medicine 2012 Apr 15;185(8):817-24.
  21. Baan B, Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, Wildenberg ME, Muncan V, Heijmans J, Verspaget HW, Richel DJ, Hardwick JCH, Hommes DW, Peppelenbosch MP, van den Brink GR. 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. Gut 2012 Dec;61(12):1708-15.
  22. Koelink PJ, Overbeek SA, Braber S, de Kruijf P, Folkerts G, Smit MJ, Kraneveld AD. Targeting chemokine receptors in chronic inflammatory diseases: An extensive review. Pharmacology & Therapeutics 2012 Jan;133(1):1-18
  23. Overbeek SA, Henricks PA, Srienc A, Koelink PJ, de Kruijff P, Lim H, Smit MJ, Zaman G, Garssen J, Nijkamp F, Kraneveld AD, Folkerts G. N-acetylated Proline-Glycine-Proline induced chemotaxis of neutrophils is independent of CXCL8 release.  Eur J Pharmacology 2011 Oct 15;668(3):443-9
  24. Braber S, Overbeek SA, Koelink PJ, Henricks PA, Garssen J, Nijkamp F, Kraneveld AD, Folkerts G. CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. Eur J Pharmacology 2011 Oct 15: 668(3):428-34
  25. Braber S, Koelink PJ, Henricks PA, Jackson P, Garssen J, Nijkamp F, Kraneveld AD, Blalock JE, Folkerts G. Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L255-65.
  26. Robanus-Maandag EC, Koelink PJ, Breukel C, Jagmohan-Changur S, van der Valk M, Verspaget HW, Fodde R, Smits R. A new conditional Apc mutant mouse model for colorectal cancer. Carcinogenesis 2010;31(5): 946-52
  27. Koelink PJ, Mieremet-Ooms MA, Corver WE, Wolanin K, Hommes DW, Lamers CB, Verspaget HW. 5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes. Inflammatory Bowel Diseases 2010; 16(3):379-89.
  28. Koelink PJ, Hawinkels LJ, Wiercinska E, Sier CF, Dijke PT, Lamers CB, Hommes DW, Verspaget HW. 5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells. Cancer Letters 2010; 287(1):82-90.
  29. Koelink PJ, Sier CF, Hommes DW, Lamers CB, Verspaget HW. Clinical significance of stromal apoptosis in colorectal cancer. Br J of Cancer 2009 1;101(5):765-73.
  30. Koelink PJ, Robanus-Maandag EC, Devilee P, Hommes DW, Lamers CB, Verspaget HW. 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional APC mouse model. Carcinogenesis 2009;20(7): 1217-24.
  31. Koelink PJ, Lamers CB, Hommes DW, Verspaget HW. Circulating cell death products predict clinical outcome of colorectal cancer patients. BMC Cancer 2009;9:88.
  32. Vischer HF, Granneman JC, Koelink PJ, Marques RB, Bogerd J. Identification of a luteinizing hormone selective determinant in the exodomain of a follicle-stimulating hormone receptor. Gen Comp Endocrinol. 2008;156(3):490-8.
  33. Koelink PJ, Verspaget HW. 5-ASA and colorectal cell-cycle progression. Gastroenterology 2007 132; (4):1635-6
  34. Kraneveld AD, Braber S, Overbeek SA, de Kruijf P, Koelink PJ, Smit MJ. “Chemokine receptors in inflammatory diseases” Chapter 6 (p107-150) in the book “Chemokine Receptors as drug targets” Wiley Press 2010 (ISBN: 978-3-527-32118-6).

 

Research programmes

Prof. MD PhD G.R. van den Brink (Intestinal mucosal homeostasis and it's deregulation in inflammatory bowel disease and during oncogenesis)

PhD M.E. Wildenberg (Inflammatory Bowel Disease - Mechanisms and therapies)