Prof. H. Spits PhD publications

2021

• Golebski Korneliusz, Layhadi Janice A., Sahiner Umit, Steveling-Klein Esther H., Lenormand Madison M., Li Rachael C. Y., Bal Suzanne M., Heesters Balthasar A., Vilà-Nadal Gemma, Hunewald Oliver, Montamat Guillem, He Feng Q., Ollert Markus, Fedina Oleksandra, Lao-Araya Mongkol, Vijverberg Susanne J. H., Maitland-van der Zee Anke-Hilse, van Drunen Cornelis M., Fokkens Wytske J., Durham Stephen R., Spits Hergen, Shamji Mohamed H. Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response Immunity 2021;54 (2):291-307.e7 [PubMed]
• Krabbendam Lisette, Bernink Jochem H., Spits Hergen Innate lymphoid cells: from helper to killer Current opinion in immunology 2021;68:28-33 [PubMed]

2020

• van de Veen Willem, Globinska Anna, Jansen Kirstin, Straumann Alex, Kubo Terufumi, Verschoor Daniëlle, Wirz Oliver F., Castro-Giner Francesc, Tan Ge, Rückert Beate, Ochsner Urs, Herrmann Marietta, Stanić Barbara, van Splunter Marloes, Huntjens Daan, Wallimann Alexandra, Fonseca Guevara Rodney J., Spits Hergen, Ignatova Desislava, Chang Yun-Tsan, Fassnacht Christina, Guenova Emmanuella, Flatz Lukas, Akdis Cezmi A., Akdis M. beccel A novel proangiogenic B cell subset is increased in cancer and chronic inflammation Science advances 2020;6 (20) [PubMed]
• Bernink Jochem H., Ohne Yoichiro, Teunissen Marcel B. M., Wang Jingya, Wu Jincheng, Krabbendam Lisette, Guntermann Christine, Volckmann Richard, Koster Jan, van Tol Sophie, Ramirez Ivan, Shrestha Yashaswi, de Rie Menno A., Spits Hergen, Ros Xavier Romero, Humbles Alison A. Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies (Nature Immunology, (2019), 20, 8, (992-1003), 10.1038/s41590-019-0423-0) Nature immunology 2020;21 (1):101 [PubMed]
• Rao Anna, Strauss Otto, Kokkinou Efthymia, Bruchard M. lanie, Tripathi Kumar P., Schlums Heinrich, Carrasco Anna, Mazzurana Luca, Konya Viktoria, Villablanca Eduardo J., Björkström Niklas K., Lindforss Ulrik, Spits Hergen, Mjösberg Jenny Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs Nature communications 2020;11 (1) [PubMed]
• Merat Sabrina J., Bru Camille, van de Berg Dorien, Molenkamp Richard, Tarr Alexander W., Koekkoek Sylvie, Kootstra Neeltje A., Prins Maria, Ball Jonathan K., Bakker Arjen Q., de Jong Menno D., Spits Hergen, Beaumont Tim, Schinkel Janke Erratum to: ‘Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance’ (J Hepatol 2019; 71(1): 14-24) (Journal of Hepatology (2019) 71(1) (14–24), (S016882781930128X), (10.1016/j.jhep.2019.02.013)) Journal of hepatology 2020;73 (4):999-1000 [PubMed]
• Krabbendam Lisette, Heesters Balthasar A., Kradolfer Chantal M. A., Spits Hergen, Bernink Jochem H. Identification of human cytotoxic ILC3s European journal of immunology 2020 [PubMed]
• Ramirez-Moral Ivan, Blok Dana C., Bernink Jochem H., Garcia-Laorden M. Isabel, Florquin Sandrine, Boon Louis, van't Veer Cornelis, Mack Matthias, Saluzzo Simona, Knapp Sylvia, Spits Hergen, de Vos Alex F., van der Poll Tom Interleukin-33 improves local immunity during Gram-negative pneumonia by a combined effect on neutrophils and inflammatory monocytes Journal of pathology 2020 [PubMed]
• de Jong G., Bartels L., Kedde M., Verdegaal E. M. E., Gillissen M. A., Levie S. E., Cercel M. G., van Hal-van Veen S. E., Fatmawati C., van de Berg D., Yasuda E., Claassen Y. B., Bakker A. Q., van der Burg S. H., Schotte R., Villaudy J., Spits H., Hazenberg M. D., van Helden P. M., Wagner K. Melanoma cells can be eliminated by sialylated CD43 × CD3 bispecific T cell engager formats in vitro and in vivo Cancer immunology, immunotherapy 2020 [PubMed]
• Kristyanto Hendy, Blomberg Nienke J., Slot Linda M., van der Voort Ellen I. H., Kerkman Priscilla F., Bakker Aleida, Burgers Leonie E., ten Brinck Robin M., van der Helm-van Mil Annette H. M., Spits Hergen, Baeten Dominique L., Huizinga Tom W. J., Toes René E. M., Scherer Hans U. Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis Science translational medicine 2020;12 (570) [PubMed]
• Bal Suzanne M., Golebski Korneliusz, Spits Hergen Plasticity of innate lymphoid cell subsets Nature reviews. Immunology 2020;20 (9):552-565 [PubMed]
• Bartels Lina T-cell engaging antibodies against new tumor-associated targets 2020. 192p. ISBN 9789464162059. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits Hergen; Co-supervisors: Wagner Koen, van Helden P. M. W.)
• van den Berg Joost H., Heemskerk Bianca, van Rooij Nienke, Gomez-Eerland Raquel, Michels Samira, van Zon Maaike, de Boer Renate, Bakker Noor A. M., Jorritsma-Smit Annelies, van Buuren Marit M., Kvistborg Pia, Spits Hergen, Schotte Remko, Mallo Henk, Karger Matthias, van der Hage Joris A., Wouters Michel W. J. M., Pronk Loes M., Geukes Foppen Marnix H., Blank Christian U., Beijnen Jos H., Nuijen Bastiaan, Schumacher Ton N., Haanen John B. A. G. Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: Boosting of neoantigen-specific T cell reactivity and long-term follow-up Journal for immunotherapy of cancer 2020;8 (2) [PubMed]

2019

• Masse-Ranson Guillemette, Dusséaux Mathilde, Fiquet Oriane, Darche Sylvie, Boussand Maud, Li Yan, Lopez-Lastra Silvia, Legrand Nicolas, Corcuff Erwan, Toubert Antoine, Centlivre Mireille, Bruel Timothée, Spits Hergen, Schwartz Olivier, Lévy Yves, Strick-Marchand H. lène, di Santo James P. Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice European journal of immunology 2019;49 (6):954-965 [PubMed]
• Bartels Lina, de Jong Greta, Gillissen Marijn A., Yasuda Etsuko, Kattler Veronika, Bru Camille, Fatmawati Christien, van Hal-van Veen Susan E., Cercel Madalina G., Moiset Gemma, Bakker Arjen Q., van Helden Pauline M., Villaudy Julien, Hazenberg Mette D., Spits Hergen, Wagner Koen A chemo-enzymatically linked bispecific antibody retargets T cells to a sialylated epitope on CD43 in acute myeloid leukemia Cancer research 2019;79 (13):3372-3382 [PubMed]
• Fehres Cynthia M., van Uden Nathalie O., Yeremenko Nataliya G., Fernandez Leticia, Franco Salinas Gabriela, van Duivenvoorde Leonie M., Huard Bertrand, Morel Jacques, Spits Hergen, Hahne Michael, Baeten Dominique L. P. APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1 Frontiers in immunology 2019;10:1368 [PubMed]
• Levels Maartje J., Fehres Cynthia M., van Baarsen Lisa G. M., van Uden Nathalie O. P., Germar Kristine, O'Toole Tom G., Blijdorp Iris C. J., Semmelink Johanna F., Doorenspleet Marieke E., Bakker Arjen Q., Krasavin Mikhail, Tomilin Alexey, Brouard Sophie, Spits Hergen, Baeten Dominique L. P., Yeremenko Nataliya G. BOB.1 controls memory B-cell fate in the germinal center reaction Journal of autoimmunity 2019;101:131-144 [PubMed]
• Bernink Jochem H., Ohne Yoichiro, Teunissen Marcel B. M., Wang Jingya, Wu Jincheng, Krabbendam Lisette, Guntermann Christine, Volckmann Richard, Koster Jan, van Tol Sophie, Ramirez Ivan, Shrestha Yashaswi, de Rie Menno A., Spits Hergen, Romero Ros Xavier, Humbles Alison A. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nature immunology 2019;20 (8):992-1003 [PubMed]
• Merat Sabrina J., Bru Camille, van de Berg Dorien, Molenkamp Richard, Tarr Alexander W., Koekkoek Sylvie, Kootstra Neeltje A., Prins Maria, Ball Jonathan K., Bakker Arjen Q., de Jong Menno D., Spits Hergen, Beaumont Tim, Schinkel Janke Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance Journal of hepatology 2019;71 (1):14-24 [PubMed]
• Nagasawa Maho, Heesters Balthasar A., Kradolfer Chantal M. A., Krabbendam Lisette, Martinez-Gonzalez Itziar, de Bruijn Marjolein J. W., Golebski Korneliusz, Hendriks Rudi W., Stadhouders Ralph, Spits Hergen, Bal Suzanne M. Erratum: Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3 (The Journal of experimental medicine (2019) 216 8 (1762-1776)) Journal of experimental medicine 2019;216 (9):2221-2222 [PubMed]
• Blijdorp Iris C. J., Menegatti Silvia, van Mens Leonike J. J., van de Sande Marleen G. H., Chen Sijia, Hreggvidsdottir Hulda S., Noordenbos Troy, Latuhihin Talia E., Bernink Jochem H., Spits Hergen, Rogge Lars, Baeten Dominique L. P., Yeremenko Nataliya G. Expansion of Interleukin-22– and Granulocyte–Macrophage Colony-Stimulating Factor–Expressing, but Not Interleukin-17A–Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis Arthritis & rheumatology (Hoboken, N.J.) 2019;71 (3):392-402 [PubMed]
• Germar Kristine, Fehres Cynthia M., Scherer Hans U., van Uden Nathalie, Pollastro Sabrina, Yeremenko Nataliya, Hansson Monika, Kerkman Priscilla F., van der Voort Ellen I. H., Reed Evan, Maassen Hanna, Kwakkenbos Mark J., Bakker Arjen Q., Klareskog Lars, Malmström Vivianne, de Vries Niek, Toes René E. M., Lundberg Karin, Spits Hergen, Baeten Dominique L. Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients Arthritis & rheumatology (Hoboken, N.J.) 2019;71 (3):340-350 [PubMed]
• Hazenberg Mette D., Haverkate Nienke J. E., van Lier Yannouck F., Spits Hergen, Krabbendam Lisette, Bemelman Willem A., Buskens Christianne J., Blom Bianca, Shikhagaie Medya M. Human ectoenzyme-expressing ILC3: Immunosuppressive innate cells that are depleted in graft-versus-host disease Blood advances 2019;3 (22):3650-3660 [PubMed]
• Golebski Korneliusz, Ros Xavier R., Nagasawa Maho, van Tol Sophie, Heesters Balthasar A., Aglmous Hajar, Kradolfer Chantal M. A., Shikhagaie Medya M., Seys Sven, Hellings P. W., van Drunen Cornelis M., Fokkens Wytske J., Spits Hergen, Bal Suzanne M. IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation Nature communications 2019;10 (1) [PubMed]
• Nagasawa Maho, Heesters Balthasar A., Kradolfer Chantal M. A., Krabbendam Lisette, Martinez-Gonzalez Itziar, de Bruijn Marjolein J. W., Golebski Korneliusz, Hendriks Rudi W., Stadhouders Ralph, Spits Hergen, Bal Suzanne M. KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3 Journal of experimental medicine 2019;216 (8):1762-1776 [PubMed]
• Fergusson Joannah R., Morgan Michael D., Bruchard Melanie, Huitema Leonie, Heesters Balthasar A., van Unen Vincent, van Hamburg Jan Piet, van der Wel Nicole N., Picavet Daisy, Koning Frits, Tas Sander W., Anderson Mark S., Marioni John C., Holländer Georg A., Spits Hergen Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens Frontiers in immunology 2019;9:2902 [PubMed]
• Spits Hergen, Villaudy Julien Modeling human lung infections in mice Nature biotechnology 2019;37 (10):1129-1130 [PubMed]
• Bartels Lina, Ploegh Hidde L., Spits Hergen, Wagner Koen Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation Methods (San Diego, Calif.) 2019;154:93-101 [PubMed]
• Merat Sabrina Protective antibody responses against HCV E1E2 in high-risk populations 2019. 194p. ISBN 9789463238083. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H. , de Jong M. D.; Co-supervisors: Schinkel C. J., Beaumont T.)

2018

• Gillissen Marijn A. Allogeneic hematopoietic stem cell transplantation as immunotherapy: B lymphocytes versus leukemia 2018. 165p. ISBN 9789462338388. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.; Co-supervisor: Hazenberg M. D.)
• Gillissen Marijn A., Kedde Martijn, Jong Greta de, Moiset Gemma, Yasuda Etsuko, Levie Sophie E., Bakker Arjen Q., Claassen Yvonne B., Wagner Koen, Böhne Martino, Hensbergen Paul J., Speijer Dave, van Helden Pauline M., Beaumont Tim, Spits Hergen, Hazenberg Mette D. AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses Blood 2018;131 (1):131-143 [PubMed]
• Nagasawa Maho Development of human plasmacytoid dendritic cells and innate lymphoid cells 2018. 249p. ISBN 9789090312224. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H. , Blom B.)
• Vivier Eric, Artis David, Colonna Marco, Diefenbach Andreas, di Santo James P., Eberl G. rard, Koyasu Shigeo, Locksley Richard M., McKenzie Andrew N. J., Mebius Reina E., Powrie Fiona, Spits Hergen Innate Lymphoid Cells: 10 Years On Cell 2018;174 (5):1054-1066 [PubMed]
• Nagasawa Maho, Spits Hergen, Ros Xavier Romero Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis Cold Spring Harbor perspectives in biology 2018;10 [PubMed]
• Krabbendam Lisette, Nagasawa Maho, Spits Hergen, Bal Suzanne M Isolation of Human Innate Lymphoid Cells Current protocols in immunology / edited by John E. Coligan ... [et al.] 2018;122 (1) [PubMed]
• Merat Sabrina J., van de Berg Dorien, Bru Camille, Yasuda Etsuko, Breij Esther, Kootstra Neeltje, Prins Maria, Molenkamp Richard, Bakker Arjen Q., de Jong Menno D., Spits Hergen, Schinkel Janke, Beaumont Tim Multiplex flow cytometry-based assay to study the breadth of antibody responses against E1E2 glycoproteins of hepatitis C virus Journal of immunological methods 2018;454:15-26 [PubMed]
• Krabbendam Lisette, Bal Suzanne M., Spits Hergen, Golebski Korneliusz New insights into the function, development, and plasticity of type 2 innate lymphoid cells Immunological reviews 2018;286 (1):74-85 [PubMed]
• García-Peydró Marina, Fuentes Patricia, Mosquera Marta, García-León María J., Alcain Juan, Rodríguez Antonio, de Miguel Purificación García, Menéndez Pablo, Weijer Kees, Spits Hergen, Scadden David T., Cuesta-Mateos Carlos, Muñoz-Calleja Cecilia, Sánchez-Madrid Francisco, Toribio María L. The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model Journal of clinical investigation 2018;128 (7):2802-2818 [PubMed]

2017

• Nagasawa Maho, Germar Kristine, Blom Bianca, Spits Hergen Human CD5(+) Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34(+) Progenitor Cells Is Regulated by Id2 Frontiers in immunology 2017;8:1047 [PubMed]
• Bernink Jochem H., Mjösberg Jenny, Spits Hergen Human ILC1: To Be or Not to Be Immunity 2017;46 (5):756-757 [PubMed]
• Bruins Jorick J., Westphal Adrie H., Albada Bauke, Wagner Koen, Bartels Lina, Spits Hergen, van Berkel Willem J. H., van Delft Floris L. Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation-Strain-Promoted (4+2) Cycloaddition Bioconjugate chemistry 2017;28 (4):1189-1193 [PubMed]
• Shikhagaie Medya M., Germar Kristine, Bal Suzanne M., Ros Xavier Romero, Spits Hergen Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases Nature reviews. Rheumatology 2017;13 (3):164-173 [PubMed]
• Shikhagaie Medya Mara, Björklund Åsa K., Mjösberg Jenny, Erjefält Jonas S., Cornelissen Anne S., Ros Xavier Romero, Bal Suzanne M., Koning Jasper J., Mebius Reina E., Mori Michiko, Bruchard Melanie, Blom Bianca, Spits Hergen Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates Cell reports 2017;18 (7):1761-1773 [PubMed]
• Gillissen Marijn A., de Jong Greta, Kedde Martijn, Yasuda Etsuko, Levie Sophie E., Moiset Gemma, Hensbergen Paul J., Bakker Arjen Q., Wagner Koen, Villaudy Jullien, van Helden Pauline M., Spits Hergen, Hazenberg Mette D. Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice Blood advances 2017;1 (19):1551-1564 [PubMed]
• Levels Maria J., van Tok Melissa N., Cantaert Tineke, Cañete Juan D., Kroese Frans G. M., Germar Kristine, Spits Hergen, Baeten Dominique L. P., Yeremenko Nataliya G. The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation Arthritis & rheumatology (Hoboken, N.J.) 2017;69 (4):750-762 [PubMed]

2016

• Gillissen M. A., de Jong G., Levie S. E., Yasuda E., Bakker A. Q., Evers L. M., Pals S. T., Huisman C., van Helden P. M., Spits H., Hazenberg M. D. AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses Bone marrow transplantation 2016;51 (9):1245-1248 [PubMed]
• Bernink Jochem H., Spits Hergen, de Jonge Wouter J. A new edge to immune surveillance by the neural system Cell research 2016;26 (11):1178-1179 [PubMed]
• Li Yan, Mention Jean-Jacques, Court Nathalie, Masse-Ranson Guillemette, Toubert Antoine, Spits Hergen, Legrand Nicolas, Corcuff Erwan, Strick-Marchand Helene, Di Santo James P. A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development European journal of immunology 2016;46 (5):1291-1299 [PubMed]
• Vély Frédéric, Barlogis Vincent, Vallentin Blandine, Neven Bénédicte, Piperoglou Christelle, Perchet Thibaut, Petit Maxime, Yessaad Nadia, Touzot Fabien, Bruneau Julie, Mahlaoui Nizar, Zucchini Nicolas, Farnarier Catherine, Michel Gérard, Moshous Despina, Blanche Stéphane, Dujardin Arnaud, Spits Hergen, Distler Jörg H. W., Ramming Andreas, Picard Capucine, Golub Rachel, Fischer Alain, Vivier Eric Corrigendum: Evidence of innate lymphoid cell redundancy in humans Nature immunology 2016;17 (12):1479 [PubMed]
• Vély Frédéric, Barlogis Vincent, Vallentin Blandine, Neven Bénédicte, Piperoglou Christelle, Ebbo Mikael, Perchet Thibaut, Petit Maxime, Yessaad Nadia, Touzot Fabien, Bruneau Julie, Mahlaoui Nizar, Zucchini Nicolas, Farnarier Catherine, Michel Gérard, Moshous Despina, Blanche Stéphane, Dujardin Arnaud, Spits Hergen, Distler Jörg H. W., Ramming Andreas, Picard Capucine, Golub Rachel, Fischer Alain, Vivier Eric Evidence of innate lymphoid cell redundancy in humans Nature immunology 2016;17 (11):1291-1299 [PubMed]
• Kwakkenbos Mark J., Diehl Sean A., Yasuda Etsuko, Bakker Arjen Q., van Geelen Caroline M. M., Lukens Michaël V., van Bleek Grada M., Widjojoatmodjo Myra N., Bogers Willy M. J. M., Mei Henrik, Radbruch Andreas, Scheeren Ferenc A., Spits Hergen, Beaumont Tim Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming (vol 16, pg 123, 2010) Nature medicine 2016;22 (12):1502 [PubMed]
• Merat Sabrina J., Molenkamp Richard, Wagner Koen, Koekkoek Sylvie M., van de Berg Dorien, Yasuda Etsuko, Böhne Martino, Claassen Yvonne B., Grady Bart P., Prins Maria, Bakker Arjen Q., de Jong Menno D., Spits Hergen, Schinkel Janke, Beaumont Tim Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance PLoS ONE 2016;11 (10):e0165047 [PubMed]
• Linnemann Carsten, van Buuren Marit M., Bies Laura, Verdegaal Els M. E., Schotte Remko, Calis Jorg J. A., Behjati Sam, Velds Arno, Hilkmann Henk, El Atmioui Dris, Visser Marten, Stratton Michael R., Haanen John B. A. G., Spits Hergen, van der Burg Sjoerd H., Schumacher Ton N. M. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma (vol 21, pg 81, 2015) Nature medicine 2016;22 (10):1192 [PubMed]
• Mjösberg Jenny, Spits Hergen Human innate lymphoid cells Journal of allergy and clinical immunology 2016;138 (5):1265-1276 [PubMed]
• Kerkman Priscilla F., Fabre Emeline, van der Voort Ellen I. H., Zaldumbide Arnaud, Rombouts Yoann, Rispens Theo, Wolbink Gertjan, Hoeben Rob C., Spits Hergen, Baeten Dominique L. P., Huizinga Tom W. J., Toes René E. M., Scherer Hans U. Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis Annals of the rheumatic diseases 2016;75 (6):1170-1176 [PubMed]
• Bal Suzanne M., Bernink Jochem H., Nagasawa Maho, Groot Jelle, Shikhagaie Medya M., Golebski Kornel, van Drunen Cornelis M., Lutter Rene, Jonkers Rene E., Hombrink Pleun, Bruchard Melanie, Villaudy Julien, Munneke J. Marius, Fokkens Wytske, Erjefält Jonas S., Spits Hergen, Ros Xavier Romero IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs Nature immunology 2016;17 (6):636-645 [PubMed]
• Munneke J. Marius Innate lymphoid cells in inflammation and repair 2016. 184p. ISBN 9789402801880. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H., van Oers M. H. J.; Co-supervisor: Hazenberg M. D.)
• Peters C. P., Mjösberg J. M., Bernink J. H., Spits H. Innate lymphoid cells in inflammatory bowel diseases Immunology letters 2016;172:124-131 [PubMed]
• Verdegaal Els M. E., de Miranda Noel F. C. C., Visser Marten, Harryvan Tom, van Buuren Marit M., Andersen Rikke S., Hadrup Sine R., van der Minne Caroline E., Schotte Remko, Spits Hergen, Haanen John B. A. G., Kapiteijn Ellen H. W., Schumacher Ton N., van der Burg Sjoerd H. Neoantigen landscape dynamics during human melanoma-T cell interactions Nature 2016;536 (7614):91-+ [PubMed]
• Spits Hergen, Bernink Jochem H., Lanier Lewis NK cells and type 1 innate lymphoid cells: partners in host defense Nature immunology 2016;17 (7):758-764 [PubMed]
• Kwakkenbos Mark J., van Helden Pauline M., Beaumont Tim, Spits Hergen Stable long-term cultures of self-renewing B cells and their applications Immunological reviews 2016;270 (1):65-77 [PubMed]
• Bernink Jochem H. The biology of human innate lymphoid cells 2016. 173p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.; Co-supervisor: Blom B.)
• Gillissen M. A., Yasuda E., de Jong G., Levie S. E., Go D., Spits H., van Helden P. M., Hazenberg M. D. The modified FACS calcein AM retention assay: A high throughput flow cytometer based method to measure cytotoxicity Journal of immunological methods 2016;434:16-23 [PubMed]

2015

• Strick-Marchand Helene, Dusséaux Mathilde, Darche Sylvie, Huntington Nicholas D., Legrand Nicolas, Masse-Ranson Guillemette, Corcuff Erwan, Ahodantin James, Weijer Kees, Spits Hergen, Kremsdorf Dina, Di Santo James P. A novel mouse model for stable engraftment of a human immune system and human hepatocytes PLoS ONE 2015;10 (3):e0119820 [PubMed]
• Calpe Silvia, Wagner Koen, El Khattabi Mohamed, Rutten Lucy, Zimberlin Cheryl, Dolk Edward, Verrips C. Theo, Medema Jan Paul, Spits Hergen, Krishnadath Kausilia K. Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies Molecular cancer therapeutics 2015;14 (11):2527-2540 [PubMed]
• Linnemann Carsten, van Buuren Marit M., Bies Laura, Verdegaal Els M. E., Schotte Remko, Calis Jorg J. A., Behjati Sam, Velds Arno, Hilkmann Henk, Atmioui Dris El, Visser Marten, Stratton Michael R., Haanen John B. A. G., Spits Hergen, van der Burg Sjoerd H., Schumacher Ton N. M. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4(+) T cells in human melanoma Nature medicine 2015;21 (1):81-85 [PubMed]
• Bernink Jochem H., Krabbendam Lisette, Germar Kristine, de Jong Esther, Gronke Konrad, Kofoed-Nielsen Michael, Munneke J. Marius, Hazenberg Mette D., Villaudy Julien, Buskens Christianne J., Bemelman Willem A., Diefenbach Andreas, Blom Bianca, Spits Hergen Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria Immunity 2015;43 (1):146-160 [PubMed]
• Rosilio C., Nebout M., Imbert V., Griessinger E., Neffati Z., Benadiba J., Hagenbeek T., Spits H., Reverso J., Ambrosetti D., Michiels J.-F., Bailly-Maitre B., Endou H., Wempe M. F., Peyron J.-F. L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia Leukemia 2015;29 (6):1253-1266 [PubMed]
• Jachimowski Lucia Clara Maria Regulation of the multifaceted functions of human plasmacytoid dendritic cells: a polyphonic policy 2015. 184p. ISBN 9789461825384. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H., Uittenbogaart C. H.; Co-supervisor: Blom B.)
• Artis David, Spits Hergen The biology of innate lymphoid cells Nature 2015;517 (7534):293-301 [PubMed]
• Spits Hergen TOX sets the stage for innate lymphoid cells Nature immunology 2015;16 (6):594-595 [PubMed]

2014

• Friesen Robert H. E., Lee Peter S., Stoop Esther J. M., Hoffman Ryan M. B., Ekiert Damian C., Bhabha Gira, Yu Wenli, Juraszek Jarek, Koudstaal Wouter, Jongeneelen Mandy, Korse Hans J. W. M., Ophorst Carla, Brinkman-van der Linden Els C. M., Throsby Mark, Kwakkenbos Mark J., Bakker Arjen Q., Beaumont Tim, Spits Hergen, Kwaks Ted, Vogels Ronald, Ward Andrew B., Goudsmit Jaap, Wilson Ian A. A common solution to group 2 influenza virus neutralization Proceedings of the National Academy of Sciences of the United States of America 2014;111 (1):445-450 [PubMed]
• Munneke J. Marius, Björklund Andreas T., Mjösberg Jenny M., Garming-Legert Karin, Bernink Jochem H., Blom Bianca, Huisman Cynthia, van Oers Marinus H. J., Spits Hergen, Malmberg Karl-Johan, Hazenberg Mette D. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease Blood 2014;124 (5):812-821 [PubMed]
• Wagner Koen, Kwakkenbos Mark J., Claassen Yvonne B., Maijoor Kelly, Böhne Martino, van der Sluijs Koenraad F., Witte Martin D., van Zoelen Diana J., Cornelissen Lisette A., Beaumont Tim, Bakker Arjen Q., Ploegh Hidde L., Spits Hergen Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity Proceedings of the National Academy of Sciences of the United States of America 2014;111 (47):16820-16825 [PubMed]
• Teunissen Marcel B. M., Munneke J. Marius, Bernink Jochem H., Spuls Phyllis I., Res Pieter C. M., te Velde Anje, Cheuk Stanley, Brouwer Marijke W. D., Menting Stef P., Eidsmo Liv, Spits Hergen, Hazenberg Mette D., Mjösberg Jenny Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients Journal of investigative dermatology 2014;134 (9):2351-2360 [PubMed]
• Villaudy Julien, Schotte Remko, Legrand Nicolas, Spits Hergen Critical assessment of human antibody generation in humanized mouse models Journal of immunological methods 2014;410:18-27 [PubMed]
• Peters Charlotte P. Crohn's disease: mucosal immunology and immune modulating therapy 2014. 187p. ISBN 9789462590625. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H., Fockens P.; Co-supervisors: te Velde A. A., Ponsioen C. Y.)
• Kwakkenbos Mark J., Bakker Arjen Q., van Helden Pauline M., Wagner Koen, Yasuda Etsuko, Spits Hergen, Beaumont Tim Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire Methods (San Diego, Calif.) 2014;65 (1):38-43 [PubMed]
• Hazenberg Mette D., Spits Hergen Human innate lymphoid cells Blood 2014;124 (5):700-709 [PubMed]
• McKenzie Andrew N. J., Spits Hergen, Eberl Gerard Innate lymphoid cells in inflammation and immunity Immunity 2014;41 (3):366-374 [PubMed]
• Hagenbeek Thijs J., Wu Xiumin, Choy Lisa, Sanchez-Irizarry Cheryll, Seshagiri Somasekar, Stinson Jeremy, Siebel Christian W., Spits Hergen Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit Cancer letters 2014;346 (2):237-248 [PubMed]
• Spits Hergen New models of human immunity Nature biotechnology 2014;32 (4):335-336 [PubMed]
• Xue Luzheng, Salimi Maryam, Panse Isabel, Mjösberg Jenny M., McKenzie Andrew N. J., Spits Hergen, Klenerman Paul, Ogg Graham Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells Journal of allergy and clinical immunology 2014;133 (4):1184-1194 [PubMed]
• Bernink Jochem H., Germar Kristine, Spits Hergen The role of ILC2 in pathology of type 2 inflammatory diseases Current opinion in immunology 2014;31:115-120 [PubMed]

2013

• Spits Hergen Group 2 innate lymphoid cells show up in the skin Immunology and cell biology 2013;91 (6):390-392 [PubMed]
• Linnemann Carsten, Heemskerk Bianca, Kvistborg Pia, Kluin Roelof J. C., Bolotin Dmitriy A., Chen Xiaojing, Bresser Kaspar, Nieuwland Marja, Schotte Remko, Michels Samira, Gomez-Eerland Raquel, Jahn Lorenz, Hombrink Pleun, Legrand Nicolas, Shu Chengyi Jenny, Mamedov Ilgar Z., Velds Arno, Blank Christian U., Haanen John B. A. G., Turchaninova Maria A., Kerkhoven Ron M., Spits Hergen, Hadrup Sine Reker, Heemskerk Mirjam H. M., Blankenstein Thomas, Chudakov Dmitriy M., Bendle Gavin M., Schumacher Ton N. M. High-throughput identification of antigen-specific TCRs by TCR gene capture Nature medicine 2013;19 (11):1534-1541 [PubMed]
• Bernink Jochem H., Peters Charlotte P., Munneke Marius, te Velde Anje A., Meijer Sybren L., Weijer Kees, Hreggvidsdottir Hulda S., Heinsbroek Sigrid E., Legrand Nicolas, Buskens Christianne J., Bemelman Willem A., Mjösberg Jenny M., Spits Hergen Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues Nature immunology 2013;14 (3):221-229 [PubMed]
• Spits Hergen, Artis David, Colonna Marco, Diefenbach Andreas, Di Santo James P., Eberl Gerard, Koyasu Shigeo, Locksley Richard M., McKenzie Andrew N. J., Mebius Reina E., Powrie Fiona, Vivier Eric Innate lymphoid cells--a proposal for uniform nomenclature Nature reviews. Immunology 2013;13 (2):145-149 [PubMed]
• Kopf Manfred, Spits Hergen Lymphocyte development Current opinion in immunology 2013;25 (2):127-129 [PubMed]
• Gentek Rebecca Mechanisms of Notch signaling specifity in lymphocytes and their leukemic counterparts 2013. 230p. ISBN 9789461823908. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.; Co-supervisor: Amsen D.)
• Gentek Rebecca, Munneke J. Marius, Helbig Christina, Blom Bianca, Hazenberg Mette D., Spits Hergen, Amsen Derk Modulation of signal strength switches Notch from an inducer of T cells to an inducer of ILC2 Frontiers in immunology 2013;4:UNSP 334 [PubMed]
• Hazenbos Wouter L. W., Kajihara Kimberly K., Vandlen Richard, Morisaki J. Hiroshi, Lehar Sophie M., Kwakkenbos Mark J., Beaumont Tim, Bakker Arjen Q., Phung Qui, Swem Lee R., Ramakrishnan Satish, Kim Janice, Xu Min, Shah Ishita M., Diep Binh An, Sai Tao, Sebrell Andrew, Khalfin Yana, Oh Angela, Koth Chris, Lin S. Jack, Lee Byoung-Chul, Strandh Magnus, Koefoed Klaus, Andersen Peter S., Spits Hergen, Brown Eric J., Tan Man-Wah, Mariathasan Sanjeev Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins PLoS pathogens 2013;9 (10):e1003653 [PubMed]
• Lounnas Nadia, Rosilio Célia, Nebout Marielle, Mary Didier, Griessinger Emmanuel, Neffati Zouhour, Chiche Johanna, Spits Hergen, Hagenbeek Thijs J., Asnafi Vahid, Poulsen Sally-Ann, Supuran Claudiu T., Peyron Jean-François, Imbert Véronique Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas Cancer letters 2013;333 (1):76-88 [PubMed]
• Karrich Julien J. Plasmacytoid dendritic cells: how to control the good, the bad, the ugly at the molecular level 2013. 192p. ISBN 9789461822314. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.; Co-supervisor: Blom B.)
• Centlivre Mireille, Legrand Nicolas, Klamer Sofieke, Liu Ying Poi, Eije Karin Jasmijn von, Bohne Martino, Rijnstra Esther Siteur-van, Weijer Kees, Blom Bianca, Voermans Carlijn, Spits Hergen, Berkhout Ben Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1 Molecular therapy. Nucleic acids 2013;2:e120 [PubMed]
• Sonnenberg Gregory F., Mjösberg Jenny, Spits Hergen, Artis David SnapShot: innate lymphoid cells Immunity 2013;39 (3):622-622.e1 [PubMed]
• McLellan Jason S., Chen Man, Joyce M. Gordon, Sastry Mallika, Stewart-Jones Guillaume B. E., Yang Yongping, Zhang Baoshan, Chen Lei, Srivatsan Sanjay, Zheng Anqi, Zhou Tongqing, Graepel Kevin W., Kumar Azad, Moin Syed, Boyington Jeffrey C., Chuang Gwo-Yu, Soto Cinque, Baxa Ulrich, Bakker Arjen Q., Spits Hergen, Beaumont Tim, Zheng Zizheng, Xia Ningshao, Ko Sung-Youl, Todd John-Paul, Rao Srinivas, Graham Barney S., Kwong Peter D. Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus Science 2013;342 (6158):592-598 [PubMed]
• Bernink Jochem, Mjösberg Jenny, Spits Hergen Th1- and Th2-like subsets of innate lymphoid cells Immunological reviews 2013;252 (1):133-138 [PubMed]
• Rosilio Célia, Lounnas Nadia, Nebout Marielle, Imbert Véronique, Hagenbeek Thijs, Spits Hergen, Asnafi Vahid, Pontier-Bres Rodolphe, Reverso Julie, Michiels Jean-François, Sahra Issam Ben, Bost Fréderic, Peyron Jean-François The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells Cancer letters 2013;336 (1):114-126 [PubMed]

2012

• Hoorweg Kerim, Peters Charlotte P., Cornelissen Ferry, Aparicio-Domingo Patricia, Papazian Natalie, Kazemier Geert, Mjösberg Jenny M., Spits Hergen, Cupedo Tom Functional differences between human NKp44(-) and NKp44(+) RORC+ innate lymphoid cells Frontiers in immunology 2012;3:72 [PubMed]
• Diehl Sean A., Schmidlin Heike, Nagasawa Maho, Blom Bianca, Spits Hergen IL-6 Triggers IL-21 production by human CD4(+) T cells to drive STAT3-dependent plasma cell differentiation in B cells Immunology and cell biology 2012;90 (8):802-811 [PubMed]
• Spits Hergen, Cupedo Tom Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function Annual review of immunology 2012;30:647-675 [PubMed]
• Weder P., Schumacher T. N. M., Spits H., Luiten R. M. Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes. Results in immunology 2012;17:88-96
• Spits Hergen, Mjösberg Jenny The Aryl Hydrocarbon Receptor: A Sentinel Safeguarding the Survival of Immune Cells in the Gut Immunity 2012;36 (1):5-7 [PubMed]
• Mjösberg Jenny, Bernink Jochem, Golebski Korneliusz, Karrich Julien J., Peters Charlotte P., Blom Bianca, te Velde Anje A., Fokkens Wytske J., van Drunen Cornelis M., Spits Hergen The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells Immunity 2012;37 (4):649-659 [PubMed]
• Mjösberg Jenny, Bernink Jochem, Peters Charlotte, Spits Hergen Transcriptional control of innate lymphoid cells European journal of immunology 2012;42 (8):1916-1923 [PubMed]
• Mjösberg Jenny, Spits Hergen Type 2 innate lymphoid cells-new members of the "type 2 franchise" that mediate allergic airway inflammation European journal of immunology 2012;42 (5):1093-1096 [PubMed]

2011

• Spits H. Another Armament in Gut Immunity: Lymphotoxin-Mediated Crosstalk between Innate Lymphoid and Dendritic Cells Cell host & microbe 2011;10 (1):3-4 [PubMed]
• Scheeren Ferenc A., van Geelen Caroline M. M., Yasuda Etsuko, Spits Hergen, Beaumont Tim Antigen-Specific Monoclonal Antibodies Isolated from B Cells Expressing Constitutively Active STAT5 PLoS ONE 2011;6 (4):e17189 [PubMed]
• Huntington Nicholas D., Alves Nuno L., Legrand Nicolas, Lim Annick, Strick-Marchand Hélène, Plet Ariane, Weijer Kees, Jacques Yannick, Spits Hergen, Di Santo James P. Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice European journal of immunology 2011;41 (10):2883-2893 [PubMed]
• Elzinga G., van Doorn J., Wiersema A. M., Klicks R. J., Andriessen A., Alblas J. G., Spits H., Post A., van Gent M. Clinical evaluation of a PHMB-impregnated biocellulose dressing on paediatric lacerations Journal of wound care 2011;20 (6):280-284 [PubMed]
• Legrand Nicolas, Huntington Nicholas D., Nagasawa Maho, Bakker Arjen Q., Schotte Remko, Strick-Marchand Hélène, de Geus Sandra J., Pouw Stephan M., Böhne Martino, Voordouw Arie, Weijer Kees, Di Santo James P., Spits Hergen Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo Proceedings of the National Academy of Sciences of the United States of America 2011;108 (32):13224-13229 [PubMed]
• Pidasheva Svetlana, Trifari Sara, Phillips Anne, Hackney Jason A., Ma Yan, Smith Ashley, Sohn Sue J., Spits Hergen, Little Randall D., Behrens Timothy W., Honigberg Lee, Ghilardi Nico, Clark Hilary F. Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q PLoS ONE 2011;6 (10):e25038 [PubMed]
• Mjösberg Jenny M., Trifari Sara, Crellin Natasha K., Peters Charlotte P., van Drunen Cornelis M., Piet Berber, Fokkens Wytske J., Cupedo Tom, Spits Hergen Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 Nature immunology 2011;12 (11):1055-1062 [PubMed]
• Huntington Nicholas D., Alves Nuno L., Legrand Nicolas, Lim Annick, Strick-Marchand Helene, Mention Jean-Jacques, Plet Ariane, Weijer Kees, Jacques Yannick, Becker Pablo D., Guzman Carlos, Soussan Patrick, Kremsdorf Dina, Spits Hergen, Di Santo James P. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo Proceedings of the National Academy of Sciences of the United States of America 2011;108 (15):6217-6222 [PubMed]
• O'Garra Anne, Gabryšová Leona, Spits Hergen Quantitative events determine the differentiation and function of helper T cells Nature immunology 2011;12 (4):288-294 [PubMed]
• Wils Evert-Jan, Rombouts Elwin J. C., van Mourik Irene, Spits Hergen, Legrand Nicolas, Braakman Eric, Cornelissen Jan J. Stem cell factor consistently improves thymopoiesis after experimental transplantation of murine or human hematopoietic stem cells in immunodeficient mice Journal of immunology (Baltimore, Md. 2011;187 (6):2974-2981 [PubMed]
• Spits Hergen, Di Santo James P. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling Nature immunology 2011;12 (1):21-27 [PubMed]

2010

• Becker Pablo D., Legrand Nicolas, van Geelen Caroline M. M., Noerder Miriam, Huntington Nicholas D., Lim Annick, Yasuda Etsuko, Diehl Sean A., Scheeren Ferenc A., Ott Michael, Weijer Kees, Wedemeyer Heiner, Di Santo James P., Beaumont Tim, Guzman Carlos A., Spits Hergen Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice PLoS ONE 2010;5 (10):e13137 [PubMed]
• Kwakkenbos Mark J., Diehl Sean A., Yasuda Etsuko, Bakker Arjen Q., van Geelen Caroline M. M., Lukens Michaël V., van Bleek Grada M., Widjojoatmodjo Myra N., Bogers Willy M. J. M., Mei Henrik, Radbruch Andreas, Scheeren Ferenc A., Spits Hergen, Beaumont Tim Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming Nature medicine 2010;16 (1):123-U164 [PubMed]
• Crellin Natasha K., Trifari Sara, Kaplan Charles D., Cupedo Tom, Spits Hergen Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells Journal of experimental medicine 2010;207 (2):281-290 [PubMed]
• Kis Loránd L., Salamon Daniel, Persson Emma K., Nagy Noémi, Scheeren Ferenc A., Spits Hergen, Klein George, Klein Eva IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter Proceedings of the National Academy of Sciences of the United States of America 2010;107 (2):872-877 [PubMed]
• Trifari Sara, Spits Hergen IL-22-producing CD4(+) T cells: Middle-men between the immune system and its environment European journal of immunology 2010;40 (9):2369-2371 [PubMed]
• van Lent Anja U., Centlivre Mireille, Nagasawa Maho, Karrich Julien J., Pouw Stephan M., Weijer Kees, Spits Hergen, Blom Bianca, Legrand Nicolas In vivo modulation of gene expression by lentiviral transduction in "human immune system" Rag2-/- gamma c -/- mice Methods in molecular biology (Clifton, N.J.) 2010;595:87-115 [PubMed]
• Schotte Remko, Schmidlin Heike, Nagasawa Maho, Dontje Wendy, Karrich Julien J., Uittenbogaart Christel, Spits Hergen, Blom Bianca Isolation and in vitro generation of gene-manipulated human plasmacytoid and conventional dendritic cells Methods in molecular biology (Clifton, N.J.) 2010;595:67-85 [PubMed]
• Crellin Natasha K., Trifari Sara, Kaplan Charles D., Satoh-Takayama Naoko, Di Santo James P., Spits Hergen Regulation of Cytokine Secretion in Human CD127(+) LTi-like Innate Lymphoid Cells by Toll-like Receptor 2 Immunity 2010;33 (5):752-764 [PubMed]
• Schotte Remko, Dontje Wendy, Nagasawa Maho, Yasuda Yuko, Bakker Arjen Q., Spits Hergen, Blom Bianca Synergy between IL-15 and Id2 Promotes the Expansion of Human NK Progenitor Cells, Which Can Be Counteracted by the E Protein HEB Required To Drive T Cell Development Journal of immunology (Baltimore, Md. 2010;184 (12):6670-6679 [PubMed]
• Scheeren Ferenc A., van Lent Anja U., Nagasawa Maho, Weijer Kees, Spits Hergen, Legrand Nicolas, Blom Bianca Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation European journal of immunology 2010;40 (4):955-965 [PubMed]

2009

• ter Brake O., Legrand N., von Eije K. J., Centlivre M., Spits H., Weijer K., Blom B., Berkhout B. Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model Gene therapy 2009;16 (1):148-153 [PubMed]
• Cupedo Tom, Crellin Natasha K., Papazian Natalie, Rombouts Elwin J., Weijer Kees, Grogan Jane L., Fibbe Willem E., Cornelissen Jan J., Spits Hergen Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC(+) CD127(+) natural killer-like cells Nature immunology 2009;10 (1):66-74 [PubMed]
• Legrand Nicolas, Ploss Alexander, Balling Rudi, Becker Pablo D., Borsotti Chiara, Brezillon Nicolas, Debarry Jennifer, de Jong Ype, Deng Hongkui, Di Santo James P., Eisenbarth Stephanie, Eynon Elizabeth, Flavell Richard A., Guzman Carlos A., Huntington Nicholas D., Kremsdorf Dina, Manns Michael P., Manz Markus G., Mention Jean-Jacques, Ott Michael, Rathinam Chozhavendan, Rice Charles M., Rongvaux Anthony, Stevens Sean, Spits Hergen, Strick-Marchand Hélène, Takizawa Hitoshi, van Lent Anja U., Wang Chengyan, Weijer Kees, Willinger Tim, Ziegler Patrick Humanized mice for modeling human infectious disease: challenges, progress, and outlook Cell host & microbe 2009;6 (1):5-9 [PubMed]
• Trifari Sara, Kaplan Charles D., Tran Elise H., Crellin Natasha K., Spits Hergen Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells Nature immunology 2009;10 (8):864-871 [PubMed]
• Huntington Nicholas D., Legrand Nicolas, Alves Nuno L., Jaron Barbara, Weijer Kees, Plet Ariane, Corcuff Erwan, Mortier Erwan, Jacques Yannick, Spits Hergen, Di Santo James P. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo Journal of experimental medicine 2009;206 (1):25-34 [PubMed]
• van Lent Anja U., Dontje Wendy, Nagasawa Maho, Siamari Rachida, Bakker Arjen Q., Pouw Stephan M., Maijoor Kelly A., Weijer Kees, Cornelissen Jan J., Blom Bianca, Di Santo James P., Spits Hergen, Legrand Nicolas IL-7 Enhances Thymic Human T Cell Development in "Human Immune System" Rag2-/-IL-2R{gamma}c-/- Mice without Affecting Peripheral T Cell Homeostasis Journal of immunology (Baltimore, Md. 2009;183 (12):7645-7655 [PubMed]
• Vivier Eric, Spits Hergen, Cupedo Tom Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nature reviews. Immunology 2009;9 (4):229-234 [PubMed]
• van Lent Anja U. G., Centlivre Mireille, Nagasawa Maho, Karrich Julien, Pouw Stephan M., Weijer Kees, Spits Hergen, Blom Bianca In Vivo Modulation of gene expression by Lentiviral Transduction in "Human Immune System" Rag2-/-yc-/-Micein: S. H. Naik, editors. Dendritic Cell Protocols. S.l.: Humana Press; 2009. p. 87-115
• van Lent Anja U. G. Lymphoid development; a dynamic interplay of timing and dosing 2009. 285p. ISBN 9789090244952. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.; Co-supervisor: Legrand N.)
• Finlay David K., Sinclair Linda V., Feijoo Carmen, Waugh Caryll M., Hagenbeek Thijs J., Spits Hergen, Cantrell Doreen A. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes Journal of experimental medicine 2009;206 (11):2441-2454 [PubMed]
• Haridass Dhivya, Yuan Qinggong, Becker Pablo D., Cantz Tobias, Iken Marcus, Rothe Michael, Narain Nidhi, Bock Michael, Nörder Miriam, Legrand Nicolas, Wedemeyer Heiner, Weijer Kees, Spits Hergen, Manns Michael P., Cai Jun, Deng Hongkui, Di Santo James P., Guzman Carlos A., Ott Michael Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice American journal of pathology 2009;175 (4):1483-1492 [PubMed]

2008

• Sinclair Linda V., Finlay David, Feijoo Carmen, Cornish Georgina H., Gray Alex, Ager Ann, Okkenhaug Klaus, Hagenbeek Thijs J., Spits Hergen, Cantrell Doreen A. Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking Nature immunology 2008;9 (6):692 [PubMed]
• Legrand Nicolas, Weijer Kees, Spits Hergen Experimental model for the study of the human immune system: production and monitoring of "human immune system" Rag2-/-gamma c-/- mice Methods in molecular biology (Clifton, N.J.) 2008;415:65-82 [PubMed]
• Dontje Wendy From progenitor cell to immune cell: Cytokines and transcription factors in human hematopoietic development. 2008. 187p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H., Blom B.)
• Scheeren Ferenc A., Diehl Sean A., Smit Laura A., Beaumont Tim, Naspetti Marianne, Bende Richard J., Blom Bianca, Karube Kennosuke, Ohshima Koichi, van Noesel Carel J. M., Spits Hergen IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis Blood 2008;111 (9):4706-4715 [PubMed]
• Sinclair Linda V., Finlay David, Feijoo Carmen, Cornish Georgina H., Gray Alex, Ager Ann, Okkenhaug Klaus, Hagenbeek Thijs J., Spits Hergen, Cantrell Doreen A. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking Nature immunology 2008;9 (5):513-521 [PubMed]
• Schmidlin Heike, Diehl Sean A., Nagasawa Maho, Scheeren Ferenc A., Schotte Remko, Uittenbogaart Christel H., Spits Hergen, Blom Bianca Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression Blood 2008;112 (5):1804-1812 [PubMed]
• Diehl Sean A., Schmidlin Heike, Nagasawa Maho, van Haren Simon D., Kwakkenbos Mark J., Yasuda Etsuko, Beaumont Tim, Scheeren Ferenc A., Spits Hergen STAT3-mediated up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation Journal of immunology (Baltimore, Md. 2008;180 (7):4805-4815 [PubMed]
• Scheeren Ferenc A., Nagasawa Maho, Weijer Kees, Cupedo Tom, Kirberg Jörg, Legrand Nicolas, Spits Hergen T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells Journal of experimental medicine 2008;205 (9):2033-2042 [PubMed]
• Hagenbeek T. J., Spits H. T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus Leukemia 2008;22 (3):608-619 [PubMed]
• Hagenbeek Thijs J. The role of the phosphatase Pten in T cell development 2008. 178p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.)
• Schmidlin Heike Transcriptional control of human plasmacytoid dendritic cell and B cell differentiation. 2008. 189p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Spits H., Uittenbogaart Christel H.; Co-supervisor: Blom B.)

2007

• Schotte R. Control of early human lymphoid development 2007. 148p. ISBN 9789090212191. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits Hergen; Co-supervisor: Blom Bianca)
• Wils Evert-Jan, Braakman Eric, Verjans Georges M. G. M., Rombouts Elwin J. C., Broers Annoek E. C., Niesters Hubert G. M., Wagemaker Gerard, Staal Frank J. T., Lowenberg Bob, Spits Hergen, Cornelissen Jan J. Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation Journal of immunology (Baltimore, Md. 2007;178 (6):3551-3557 [PubMed]
• van Lent Anja U., Nagasawa Maho, van Loenen Marleen M., Schotte Remko, Schumacher Ton N. M., Heemskerk Mirjam H. M., Spits Hergen, Legrand Nicolas Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors Journal of immunology (Baltimore, Md. 2007;179 (8):4959-4968 [PubMed]
• Scheeren Ferenc Human B cell development and oncogenesis 2007. 177p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits Hergen)
• Legrand Nicolas, Dontje Wendy, van Lent Anja U., Spits Hergen, Blom Bianca Human thymus regeneration and T cell reconstitution Seminars in immunology 2007;19 (5):280-288 [PubMed]
• Broers Annoek E. C., Bruinsma Marieke, Posthumus-van Sluijs Sandra J., Wils Evert-Jan, Spits Hergen, Lowenberg Bob, Braakman Eric, Cornelissen Jan J. IL-7-mediated protection against minor-antigen-mismatched allograft rejection is associated with enhanced recovery of regulatory T cells Haematologica 2007;92 (8):1099-1106 [PubMed]
• Spits Hergen, Lanier Lewis L. Natural killer or dendritic: what's in a name? Immunity 2007;26 (1):11-16 [PubMed]
• An Dong Sung, Poon Betty, Tsong Fang Raphael Ho, Weijer Kees, Blom Bianca, Spits Hergen, Chen Irvin S. Y., Uittenbogaart Christel H. Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection Clinical and vaccine immunology 2007;14 (4):391-396 [PubMed]

2006

• Baba Yoshihiro, Yokota Takafumi, Spits Hergen, Garrett Karla P., Hayashi Shin-Ichi, Kincade Paul W. Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture Journal of immunology (Baltimore, Md. 2006;177 (4):2294-2303 [PubMed]
• Dontje Wendy, Schotte Remko, Cupedo Tom, Nagasawa Maho, Scheeren Ferenc, Gimeno Ramon, Spits Hergen, Blom Bianca Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B Blood 2006;107 (6):2446-2452 [PubMed]
• Blom Bianca, Spits Hergen Development of human lymphoid cells Annual review of immunology 2006;24:287-320 [PubMed]
• Legrand Nicolas, Weijer Kees, Spits Hergen Experimental models to study development and function of the human immune system in vivo Journal of immunology (Baltimore, Md. 2006;176 (4):2053-2058 [PubMed]
• Reits Eric A., Hodge James W., Herberts Carla A., Groothuis Tom A., Chakraborty Mala, Wansley Elizabeth K., Camphausen Kevin, Luiten Rosalie M., de Ru Arnold H., Neijssen Joost, Griekspoor Alexander, Mesman Elly, Verreck Frank A., Spits Hergen, Schlom Jeffrey, van Veelen Peter, Neefjes Jacques J. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy Journal of experimental medicine 2006;203 (5):1259-1271 [PubMed]
• Schmidlin Heike, Dontje Wendy, Groot Fedde, Ligthart Suzanne J., Colantonio Arnaud D., Oud Monique E., Schilder-Tol Esther J., Spaargaren Marcel, Spits Hergen, Uittenbogaart Christel H., Blom Bianca Stimulated plasmacytoid dendritic cells impair human T-cell development Blood 2006;108 (12):3792-3800 [PubMed]
• Legrand Nicolas, Cupedo Tom, van Lent Anja U., Ebeli Menno J., Weijer Kees, Hanke Thomas, Spits Hergen Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice Blood 2006;108 (1):238-245 [PubMed]

2005

• Cupedo Tom, Nagasawa Maho, Weijer Kees, Blom Bianca, Spits Hergen Development and activation of regulatory T cells in the human fetus European journal of immunology 2005;35 (2):383-390 [PubMed]
• Luiten Rosalie M., Kueter Esther W. M., Mooi Wolter, Gallee Maarten P. W., Rankin Elaine M., Gerritsen Winald R., Clift Shirley M., Nooijen Willem J., Weder Pauline, van de Kasteele Willeke F., Sein Johan, van den Berk Paul C. M., Nieweg Omgo E., Berns Anton M., Spits Hergen, de Gast Gijsbert C. Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients Journal of clinical oncology 2005;23 (35):8978-8991 [PubMed]
• Scheeren Ferenc A., Naspetti Marianne, Diehl Sean, Schotte Remko, Nagasawa Maho, Wijnands Erwin, Gimeno Ramon, Vyth-Dreese Florry A., Blom Bianca, Spits Hergen STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression Nature immunology 2005;6 (3):303-313 [PubMed]

2004

• Gurney Kevin B., Colantonio Arnaud D., Blom Bianca, Spits Hergen, Uittenbogaart Christel H. Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection Journal of immunology (Baltimore, Md. 2004;173 (12):7269-7276 [PubMed]
• Verra Natascha C. V., Jorritsma Annelies, Weijer Kees, Ruizendaal Janneke J., Voordouw Arie, Weder Pauline, Hooijberg Erik, Schumacher Ton N. M., Haanen John B. A. G., Spits Hergen, Luiten Rosalie M. Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice Cancer research 2004;64 (6):2153-2161 [PubMed]
• Gimeno Ramon, Weijer Kees, Voordouw Arie, Uittenbogaart Christel H., Legrand Nicolas, Alves Nuno L., Wijnands Erwin, Blom Bianca, Spits Hergen Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells Blood 2004;104 (13):3886-3893 [PubMed]
• Schotte Remko, Nagasawa Maho, Weijer Kees, Spits Hergen, Blom Bianca The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development Journal of experimental medicine 2004;200 (11):1503-1509 [PubMed]
• Hagenbeek Thijs J., Naspetti Marianne, Malergue Fabrice, Garçon Fabien, Nunès Jacques A., Cleutjens Kitty B. J. M., Trapman Jan, Krimpenfort Paul, Spits Hergen The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling Journal of experimental medicine 2004;200 (7):883-894 [PubMed]
• drs Morra M. The X-linked lymphoproliferative syndrome: molecualr and cellular basis of the disease 2004. 212p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.)

2003

• van Rijn Rozemarijn S., Simonetti Elles R., Hagenbeek Anton, Hogenes Marieke C. H., de Weger Roel A., Canninga-van Dijk Marijke R., Weijer Kees, Spits Hergen, Storm Gert, van Bloois Louis, Rijkers Ger, Martens Anton C. M., Ebeling Saskia B. A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice Blood 2003;102 (7):2522-2531 [PubMed]
• Wolkers M. C. Dissection of spontaneous and therapy-induced T cell immunity in mice 2003. 104p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Spits H.; Co-supervisor: Schumacher T. N. J.)
• Luiten Rosalie M., Péne Jérome, Yssel Hans, Spits Hergen Ectopic hTERT expression extends the life span of human CD4(+) helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis Blood 2003;101 (11):4512-4519 [PubMed]
• Broers Annoek E. C., Posthumus-van Sluijs Sandra J., Spits Hergen, van der Holt Bronno, Löwenberg Bob, Braakman Eric, Cornelissen Jan J. Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants Blood 2003;102 (4):1534-1540 [PubMed]
• Roth Alexander, Yssel Hans, Pene Jerome, Chavez Elizabeth A., Schertzer Mike, Lansdorp Peter M., Spits Hergen, Luiten Rosalie M. Telomerase levels control the lifespan of human T lymphocytes Blood 2003;102 (3):849-857 [PubMed]
• Schotte Remko, Rissoan Marie-Clotilde, Bendriss-Vermare Nathalie, Bridon Jean-Michel, Duhen Thomas, Weijer Kees, Brière Francine, Spits Hergen The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development Blood 2003;101 (3):1015-1023 [PubMed]

2002

• Shvarts Avi, Brummelkamp Thijn R., Scheeren Ferenc, Koh Eugene, Daley George Q., Spits Hergen, Bernards René A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling Genes & development 2002;16 (6):681-686 [PubMed]
• Blom Bianca, Ligthart Suzanne J. W. C., Schotte Remko, Spits Hergen Developmental origin of pre-DC2 Human immunology 2002;63 (12):1072-1080 [PubMed]
• Spits Hergen Development of alphabeta T cells in the human thymus Nature reviews. Immunology 2002;2 (10):760-772 [PubMed]
• Yssel Hans, Spits Hergen Generation and maintenance of cloned human T cell lines Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 7:Unit 7.19 [PubMed]
• van Montfrans Catherine, Hooijberg Erik, Rodriguez Pena Maria Sol, de Jong Esther C., Spits Hergen, te Velde Anje A., van Deventer Sander J. H. Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer Gastroenterology 2002;123 (6):1877-1888 [PubMed]
• Weijer Kees, Uittenbogaart Christel H., Voordouw Arie, Couwenberg Franka, Seppen Jurgen, Blom Bianca, Vyth-Dreese Florry A., Spits Hergen Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo Blood 2002;99 (8):2752-2759 [PubMed]

2001

• Reche P. A., Soumelis V., Gorman D. M., Clifford T., Liu N. N., Travis M., Zurawski S. M., Johnston J., Liu Y. J., Spits H., de Waal Malefyt R., Kastelein R. A., Bazan J. F. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells Journal of immunology (Baltimore, Md. 2001;167 (1):336-343 [PubMed]

2000

• van Oosterhout Y. V., van Emst L., Schattenberg A. V., Tax W. J., Ruiter D. J., Spits H., Nagengast F. M., Masereeuw R., Evers S., de Witte T., Preijers F. W. A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease Blood 2000;95 (12):3693-3701 [PubMed]
• Kessels H. W., van den Boom M. D., Spits H., Hooijberg E., Schumacher T. N. Changing T cell specificity by retroviral T cell receptor display Proceedings of the National Academy of Sciences of the United States of America 2000;97 (26):14578-14583 [PubMed]
• Galy A., Christopherson I., Ferlazzo G., Liu G., Spits H., Georgopoulos K. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells Blood 2000;95 (1):128-137 [PubMed]
• Dardalhon V., Jaleco S., Rebouissou C., Ferrand C., Skander N., Swainson L., Tiberghien P., Spits H., Noraz N., Taylor N. Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector Blood 2000;96 (3):885-893 [PubMed]
• Spits H., Couwenberg F., Bakker A. Q., Weijer K., Uittenbogaart C. H. Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2 Journal of experimental medicine 2000;192 (12):1775-1784 [PubMed]
• Hooijberg E., Ruizendaal J. J., Snijders P. J., Kueter E. W., Walboomers J. M., Spits H. Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase Journal of immunology (Baltimore, Md. 2000;165 (8):4239-4245 [PubMed]
• Hooijberg E., Bakker A. Q., Ruizendaal J. J., Spits H. NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells Blood 2000;96 (2):459-466 [PubMed]
• Bukowski J. F., Roncarolo M. G., Spits H., Krangel M. S., Morita C. T., Brenner M. B., Band H. T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity European journal of immunology 2000;30 (11):3199-3206 [PubMed]
• Spits H., Res P., Jaleco A. C. Techniques for studying development of human natural killer cells and T cells Methods in molecular biology (Clifton, N.J.) 2000;121:25-38 [PubMed]

1999

• Res P., Spits H. Developmental stages in the human thymus Seminars in immunology 1999;11 (1):39-46 [PubMed]
• Blom B., Heemskerk M. H., Verschuren M. C., van Dongen J. J., Stegmann A. P., Bakker A. Q., Couwenberg F., Res P. C., Spits H. Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors EMBO journal 1999;18 (10):2793-2802 [PubMed]
• Pallard C., Stegmann A. P., van Kleffens T., Smart F., Venkitaraman A., Spits H. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors Immunity 1999;10 (5):525-535 [PubMed]
• Heemskerk M. H., Hooijberg E., Ruizendaal J. J., van der Weide M. M., Kueter E., Bakker A. Q., Schumacher T. N., Spits H. Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells Cellular immunology 1999;195 (1):10-17 [PubMed]
• Res P. C., Couwenberg F., Vyth-Dreese F. A., Spits H. Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus Blood 1999;94 (8):2647-2657 [PubMed]
• Jaleco A. C., Stegmann A. P., Heemskerk M. H., Couwenberg F., Bakker A. Q., Weijer K., Spits H. Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3 Blood 1999;94 (8):2637-2646 [PubMed]
• Dardalhon V., Noraz N., Pollok K., Rebouissou C., Boyer M., Bakker A. Q., Spits H., Taylor N. Green fluorescent protein as a selectable marker of fibronectin-facilitated retroviral gene transfer in primary human T lymphocytes Human gene therapy 1999;10 (1):5-14 [PubMed]
• Jacobs H., Krimpenfort P., Haks M., Allen J., Blom B., Démollière C., Kruisbeek A., Spits H., Berns A. PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice Journal of experimental medicine 1999;190 (8):1059-1068 [PubMed]
• Blom B., Verschuren M. C., Heemskerk M. H., Bakker A. Q., van Gastel-Mol E. J., Wolvers-Tettero I. L., van Dongen J. J., Spits H. TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation Blood 1999;93 (9):3033-3043 [PubMed]

1998

• Di Santo J. P., Fehling H. J., Malissen B., Spits H., Borst J. Antigen receptors in lymphoid cell development and lymphocyte activation Research in immunology 1998;149 (9):868-871 [PubMed]
• Martínez-Cáceres E., Jaleco A. C., Res P., Noteboom E., Weijer K., Spits H. Characterization of CD34+ thymic stromal cells located in the subcapsular cortex of the human thymus Experimental hematology 1998;26 (7):588-596 [PubMed]
• Spits H., Blom B., Jaleco A. C., Weijer K., Verschuren M. C., van Dongen J. J., Heemskerk M. H., Res P. C. Early stages in the development of human T, natural killer and thymic dendritic cells Immunological reviews 1998;165:75-86 [PubMed]
• Verschuren M. C., Blom B., Bogers A. J., Spits H., van Dongen J. J. PJA-BP expression and TCR delta deletion during human T cell differentiation International immunology 1998;10 (12):1873-1880 [PubMed]
• Blom B., Res P. C., Spits H. T cell precursors in man and mice Critical reviews in immunology 1998;18 (4):371-388 [PubMed]

1997

• Carbone E., Ruggiero G., Terrazzano G., Palomba C., Manzo C., Fontana S., Spits H., Kärre K., Zappacosta S. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction Journal of experimental medicine 1997;185 (12):2053-2060 [PubMed]
• Res P., Blom B., Hori T., Weijer K., Spits H. Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development Journal of experimental medicine 1997;185 (1):141-151 [PubMed]
• Jaleco A. C., Blom B., Res P., Weijer K., Lanier L. L., Phillips J. H., Spits H. Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells Journal of immunology (Baltimore, Md. 1997;159 (2):694-702 [PubMed]
• Bruno L., Res P., Dessing M., Cella M., Spits H. Identification of a committed T cell precursor population in adult human peripheral blood Journal of experimental medicine 1997;185 (5):875-884 [PubMed]
• Heemskerk M. H., Blom B., Nolan G., Stegmann A. P., Bakker A. Q., Weijer K., Res P. C., Spits H. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3 Journal of experimental medicine 1997;186 (9):1597-1602 [PubMed]
• Schinkel A. H., Mayer U., Wagenaar E., Mol C. A., van Deemter L., Smit J. J., van der Valk M. A., Voordouw A. C., Spits H., van Tellingen O., Zijlmans J. M., Fibbe W. E., Borst P. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins Proceedings of the National Academy of Sciences of the United States of America 1997;94 (8):4028-4033 [PubMed]
• Blom B., Res P., Noteboom E., Weijer K., Spits H. Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage Journal of immunology (Baltimore, Md. 1997;158 (8):3571-3577 [PubMed]

1996

• Res P., Martínez-Cáceres E., Cristina Jaleco A., Staal F., Noteboom E., Weijer K., Spits H. CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells Blood 1996;87 (12):5196-5206 [PubMed]
• Ruggiero G., Cáceres E. M., Voordouw A., Noteboom E., Graf D., Kroczek R. A., Spits H. CD40 expressed on thymic epithelial cells provides costimulation for proliferation but not for apoptosis of human thymocytes Journal of immunology (Baltimore, Md. 1996;156 (10):3737-3746 [PubMed]
• Lebedeva M. I., Fields B. A., Spits H., Panchamoorthy G., Brenner M. B., Mariuzza R. A. Cloning, expression, and crystallization of the V delta domain of a human gamma delta T-cell receptor Protein science 1996;5 (12):2638-2642 [PubMed]
• Martinez-Cáceres E., Ruggiero G., Spits H., Juan M., Barceló J., Vives J., Martorell J., Viñas O. Stimulation through CD50 (ICAM-3) induces both activation and programmed cell death of human thymocytes Tissue antigens 1996;48 (6):626-635 [PubMed]
• Chu D. H., Spits H., Peyron J. F., Rowley R. B., Bolen J. B., Weiss A. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling EMBO journal 1996;15 (22):6251-6261 [PubMed]
• Staal F. J., Bakker A. Q., Verkuijlen M., van Oort E., Spits H. Use of bicistronic retroviral vectors encoding the LacZ gene together with a gene of interest: a method to select producer cells and follow transduced target cells Cancer gene therapy 1996;3 (5):345-351 [PubMed]

1995

• Spits H., Lanier L. L., Phillips J. H. Development of human T and natural killer cells Blood 1995;85 (10):2654-2670 [PubMed]
• Staal F. J., Res P. C., Weijer K., Spits H. Development of retrovirally marked human T progenitor cells into mature thymocytes International immunology 1995;7 (8):1301-1309 [PubMed]
• Bárcena A., Muench M. O., Roncarolo M. G., Spits H. Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus Leukemia & lymphoma 1995;17 (1-2):1-11 [PubMed]

1994

• Hintzen R. Q., Lens S. M., Koopman G., Pals S. T., Spits H., van Lier R. A. CD70 represents the human ligand for CD27 International immunology 1994;6 (3):477-480 [PubMed]
• Spits H., Bárcena A., Hori T., Sánchez M. J., Phillips J. H., Galy A. Early events in human intrathymic T-cell development Research in immunology 1994;145 (2):128-34; discussion 155-8 [PubMed]
• Spits H. Early stages in human and mouse T-cell development Current opinion in immunology 1994;6 (2):212-221 [PubMed]
• Bárcena A., Muench M. O., Roncarolo M. G., Spits H. In search of T-cell progenitors in the human foetal liver Research in immunology 1994;145 (2):120-3; discussion 155-8 [PubMed]
• Vandekerckhove B. A., Bárcena A., Schols D., Mohan-Peterson S., Spits H., Roncarolo M. G. In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells Journal of immunology (Baltimore, Md. 1994;152 (4):1738-1743 [PubMed]
• Bárcena A., Galy A. H., Punnonen J., Muench M. O., Schols D., Roncarolo M. G., de Vries J. E., Spits H. Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture Journal of experimental medicine 1994;180 (1):123-132 [PubMed]

1993

• Mutis T., Kraakman E. M., Cornelisse Y. E., Haanen J. B., Spits H., de Vries R. R., Ottenhoff T. H. Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients Journal of immunology (Baltimore, Md. 1993;150 (10):4641-4651 [PubMed]
• de Waal Malefyt R., Verma S., Bejarano M. T., Ranes-Goldberg M., Hill M., Spits H. CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes European journal of immunology 1993;23 (2):418-424 [PubMed]
• Bacchetta R., Vandekerckhove B. A., Touraine J. L., Bigler M., Martino S., Gebuhrer L., de Vries J. E., Spits H., Roncarolo M. G. Chimerism and tolerance to host and donor in severe combined immunodeficiencies transplanted with fetal liver stem cells Journal of clinical investigation 1993;91 (3):1067-1078 [PubMed]
• Azuma M., Yssel H., Phillips J. H., Spits H., Lanier L. L. Functional expression of B7/BB1 on activated T lymphocytes Journal of experimental medicine 1993;177 (3):845-850 [PubMed]
• Sánchez M. J., Spits H., Lanier L. L., Phillips J. H. Human natural killer cell committed thymocytes and their relation to the T cell lineage Journal of experimental medicine 1993;178 (6):1857-1866 [PubMed]
• Ranes-Goldberg M. G., Hori T., Mohan-Peterson S., Spits H. Identification of human pre-T/NK cell-associated genes Journal of immunology (Baltimore, Md. 1993;151 (10):5810-5821 [PubMed]
• Bárcena A., Muench M. O., Galy A. H., Cupp J., Roncarolo M. G., Phillips J. H., Spits H. Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development Blood 1993;82 (11):3401-3414 [PubMed]
• Galy A., Verma S., Bárcena A., Spits H. Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development Journal of experimental medicine 1993;178 (2):391-401 [PubMed]
• Yssel H., Schneider P., Spits H. Production of IL4 by human T cells and regulation of differentiation of T-cell subsets by IL4 Research in immunology 1993;144 (8):610-616 [PubMed]
• Galy A. H., Spits H., Hamilton J. A. Regulation of M-CSF production by cultured human thymic epithelial cells Lymphokine and cytokine research 1993;12 (5):265-270 [PubMed]
• Touraine J. L., Roncarolo M. G., Plotnicky H., Bachetta R., Spits H. T lymphocytes from human chimeras do recognize antigen in the context of allogeneic determinants of the major histocompatibility complex Immunology letters 1993;39 (1):9-12 [PubMed]
• Galy A. H., de Waal Malefyt R., Barcena A., Peterson S. M., Spits H. Untransfected and SV40-transfected fetal and postnatal human thymic stromal cells. Analysis of phenotype, cytokine gene expression and cytokine production Thymus 1993;22 (1):13-33 [PubMed]

1992

• Galy A. H., Spits H. CD40 is functionally expressed on human thymic epithelial cells Journal of immunology (Baltimore, Md. 1992;149 (3):775-782 [PubMed]
• Hsu D. H., Moore K. W., Spits H. Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity International immunology 1992;4 (5):563-569 [PubMed]
• Lanier L. L., Chang C., Spits H., Phillips J. H. Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes Journal of immunology (Baltimore, Md. 1992;149 (6):1876-1880 [PubMed]
• Spits H., de Waal Malefyt R. Functional characterization of human IL-10 International archives of allergy and immunology 1992;99 (1):8-15 [PubMed]
• Hori T., Phillips J. H., Duncan B., Lanier L. L., Spits H. Human fetal liver-derived CD7+CD2lowCD3-CD56- clones that express CD3 gamma, delta, and epsilon and proliferate in response to interleukin-2 (IL-2), IL-3, IL-4, or IL-7: implications for the relationship between T and natural killer cells Blood 1992;80 (5):1270-1278 [PubMed]
• Yssel H., de Waal Malefyt R., Roncarolo M. G., Abrams J. S., Lahesmaa R., Spits H., de Vries J. E. IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells Journal of immunology (Baltimore, Md. 1992;149 (7):2378-2384 [PubMed]
• de Waal Malefyt R., Yssel H., Roncarolo M. G., Spits H., de Vries J. E. Interleukin-10 Current opinion in immunology 1992;4 (3):314-320 [PubMed]
• Gascan H., Aversa G. G., Gauchat J. F., van Vlasselaer P., Roncarolo M. G., Yssel H., Kehry M., Spits H., de Vries J. E. Membranes of activated CD4+ T cells expressing T cell receptor (TcR) alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4 European journal of immunology 1992;22 (5):1133-1141 [PubMed]
• Phillips J. H., Hori T., Nagler A., Bhat N., Spits H., Lanier L. L. Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins Journal of experimental medicine 1992;175 (4):1055-1066 [PubMed]
• Momburg F., Ortiz-Navarrete V., Neefjes J., Goulmy E., van de Wal Y., Spits H., Powis S. J., Butcher G. W., Howard J. C., Walden P. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation Nature 1992;360 (6400):174-177 [PubMed]
• Lanier L. L., Spits H., Phillips J. H. The developmental relationship between NK cells and T cells Immunology today 1992;13 (10):392-395 [PubMed]

1991

• Phillips J. H., McKinney L., Azuma M., Spits H., Lanier L. L. A novel beta 4, alpha 6 integrin-associated epithelial cell antigen involved in natural killer cell and antigen-specific cytotoxic T lymphocyte cytotoxicity Journal of experimental medicine 1991;174 (6):1571-1581 [PubMed]
• Roncarolo M. G., Bacchetta R., Bigler M., Touraine J. L., de Vries J. E., Spits H. A SCID patient reconstituted with HLA-incompatible fetal stem cells as a model for studying transplantation tolerance Blood cells 1991;17 (2):391-402 [PubMed]
• Hori T., Spits H. Characterization of triple negative clones isolated from post-natal human thymus Advances in experimental medicine and biology 1991;292:97-104 [PubMed]
• O'Hehir R. E., Yssel H., Verma S., de Vries J. E., Spits H., Lamb J. R. Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy International immunology 1991;3 (8):819-826 [PubMed]
• Hori T., Spits H. Clonal analysis of human CD4-CD8-CD3- thymocytes highly purified from postnatal thymus Journal of immunology (Baltimore, Md. 1991;146 (7):2116-2121 [PubMed]
• Vandekerckhove B. A., Krowka J. F., McCune J. M., de Vries J. E., Spits H., Roncarolo M. G. Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse Journal of immunology (Baltimore, Md. 1991;146 (12):4173-4179 [PubMed]
• Hori T., de Waal Malefyt R., Duncan B. W., Harrison M. R., Roncarolo M. G., Spits H. Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3 International immunology 1991;3 (4):353-357 [PubMed]
• Hori T., Paliard X., de Waal Malefijt R., Ranes M., Spits H. Comparative analysis of CD8 expressed on mature CD4+ CD8+ T cell clones cultured with IL-4 and that on CD8+ T cell clones: implication for functional significance of CD8 beta International immunology 1991;3 (7):737-741 [PubMed]
• Paliard X., de Vries J. E., Spits H. Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2 Cellular immunology 1991;135 (2):383-393 [PubMed]
• de Vries J. E., de Waal Malefyt R., Yssel H., Roncarolo M. G., Spits H. Do human TH1 and TH2 CD4+ clones exist? Research in immunology 1991;142 (1):59-63 [PubMed]
• Spits H., Yssel H., Brockelhurst C., Krangel M. Evidence for controlled gene rearrangements and cytokine production during development of human TCR gamma delta+ lymphocytes Current topics in microbiology and immunology 1991;173:47-55 [PubMed]
• Spits H., Paliard X., Vandekerckhove Y., van Vlasselaer P., de Vries J. E. Functional and phenotypic differences between CD4+ and CD4- T cell receptor-gamma delta clones from peripheral blood Journal of immunology (Baltimore, Md. 1991;147 (4):1180-1188 [PubMed]
• Morita C. T., Verma S., Aparicio P., Martinez C., Spits H., Brenner M. B. Functionally distinct subsets of human gamma/delta T cells European journal of immunology 1991;21 (12):2999-3007 [PubMed]
• Gascan H., Gauchat J. F., Roncarolo M. G., Yssel H., Spits H., de Vries J. E. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones Journal of experimental medicine 1991;173 (3):747-750 [PubMed]
• Spits H. Human T cell receptor gamma delta + T cells Seminars in immunology 1991;3 (2):119-129 [PubMed]
• Hori T., Cupp J., Wrighton N., Lee F., Spits H. Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset Journal of immunology (Baltimore, Md. 1991;146 (12):4078-4084 [PubMed]
• Galy A. H., Spits H. IL-1, IL-4, and IFN-gamma differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells Journal of immunology (Baltimore, Md. 1991;147 (11):3823-3830 [PubMed]
• de Waal Malefyt R., Haanen J., Spits H., Roncarolo M. G., te Velde Anje, Figdor C., Johnson K., Kastelein R., Yssel H., de Vries J. E. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression Journal of experimental medicine 1991;174 (4):915-924 [PubMed]
• Roncarolo M. G., Bigler M., Haanen J. B., Yssel H., Bacchetta R., de Vries J. E., Spits H. Natural killer cell clones can efficiently process and present protein antigens Journal of immunology (Baltimore, Md. 1991;147 (3):781-787 [PubMed]
• Alexandre D., Chuchana P., Roncarolo M. G., Yssel H., Spits H., Lefranc G., Lefranc M. P. Reciprocal hybrid joints demonstrate successive V-J rearrangements on the same chromosome in the human TCR gamma locus International immunology 1991;3 (10):973-982 [PubMed]
• Haanen J. B., de Waal Malefijt R., Res P. C., Kraakman E. M., Ottenhoff T. H., de Vries R. R., Spits H. Selection of a human T helper type 1-like T cell subset by mycobacteria Journal of experimental medicine 1991;174 (3):583-592 [PubMed]
• Spertini F., Spits H., Geha R. S. Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules Proceedings of the National Academy of Sciences of the United States of America 1991;88 (17):7533-7537 [PubMed]
• Peyron J. F., Verma S., de Waal Malefyt R., Sancho J., Terhorst C., Spits H. The CD45 protein tyrosine phosphatase is required for the completion of the activation program leading to lymphokine production in the Jurkat human T cell line International immunology 1991;3 (12):1357-1366 [PubMed]

1990

• Krangel M. S., Yssel H., Brocklehurst C., Spits H. A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production Journal of experimental medicine 1990;172 (3):847-859 [PubMed]
• Spits H., Yssel H., de Vries J. E. Analysis of antigen specificity of human TCR gamma delta + T cells Research in immunology 1990;141 (7):636-640 [PubMed]
• Spits H., Paliard X., Engelhard V. H., de Vries J. E. Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156 Journal of immunology (Baltimore, Md. 1990;144 (11):4156-4162 [PubMed]
• Hsu D. H., de Waal Malefyt R., Fiorentino D. F., Dang M. N., Vieira P., de Vries J., Spits H., Mosmann T. R., Moore K. W. Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1 Science 1990;250 (4982):830-832 [PubMed]
• Bacchetta R., de Waal Malefijt R., Yssel H., Abrams J., de Vries J. E., Spits H., Roncarolo M. G. Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4 Journal of immunology (Baltimore, Md. 1990;144 (3):902-908 [PubMed]
• de Waal Malefyt R., Yssel H., Spits H., de Vries J. E., Sancho J., Terhorst C., Alarcon B. Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes Journal of immunology (Baltimore, Md. 1990;145 (7):2297-2303 [PubMed]
• Haanen J. B., Ottenhoff T. H., Lai A Fat R. F., Soebono H., Spits H., de Vries R. R. Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria Journal of immunology (Baltimore, Md. 1990;145 (11):3898-3904 [PubMed]
• Spits H., Touraine J. L., Yssel H., de Vries J. E., Roncarolo M. G. Presence of host-reactive and MHC-restricted T cells in a transplanted severe combined immunodeficient (SCID) patient suggest positive selection and absence of clonal deletion Immunological reviews 1990;116:101-116 [PubMed]
• Trounstine M. L., Peltz G. A., Yssel H., Huizinga T. W., von dem Borne A. E., Spits H., Moore K. W. Reactivity of cloned, expressed human Fc gamma RIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of Fc gamma RIII International immunology 1990;2 (4):303-310 [PubMed]

1989

• Paliard X., Yssel H., Blanchard D., Waitz J. A., deVries J. E., Spits H. Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta+ and gamma delta+ human T cell clones isolated in IL-4 Journal of immunology (Baltimore, Md. 1989;143 (2):452-457 [PubMed]
• Spits H., Paliard X., de Vries J. E. Antigen-specific, but not natural killer, activity of T cell receptor-gamma delta cytotoxic T lymphocyte clones involves secretion of N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and influx of Ca2+ ions Journal of immunology (Baltimore, Md. 1989;143 (5):1506-1511 [PubMed]
• Hata S., Clabby M., Devlin P., Spits H., de Vries J. E., Krangel M. S. Diversity and organization of human T cell receptor delta variable gene segments Journal of experimental medicine 1989;169 (1):41-57 [PubMed]
• Yssel H., de Waal Malefyt R., Duc Dodon M. D., Blanchard D., Gazzolo L., de Vries J. E., Spits H. Human T cell leukemia/lymphoma virus type I infection of a CD4+ proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells Journal of immunology (Baltimore, Md. 1989;142 (7):2279-2289 [PubMed]
• Rousset F., Billaud M., Blanchard D., Figdor C., Lenoir G. M., Spits H., de Vries J. E. IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions Journal of immunology (Baltimore, Md. 1989;143 (5):1490-1498 [PubMed]
• de Vries J. E., Yssel H., Spits H. Interplay between the TCR/CD3 complex and CD4 or CD8 in the activation of cytotoxic T lymphocytes Immunological reviews 1989;109:119-141 [PubMed]
• de Waal Malefyt R., Alarcon B., Yssel H., Sancho J., Miyajima A., Terhorst C. P., Spits H., de Vries J. E. Introduction of T cell receptor (TCR)-alpha cDNA has differential effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells Journal of immunology (Baltimore, Md. 1989;142 (10):3634-3642 [PubMed]
• Spits H., Yssel H., de Vries J. E. The induction of T cell-mediated cytolysis by monoclonal antibodies against the T cell receptor/CD3 complex International reviews of immunology 1989;4 (2):115-132 [PubMed]
• Blanchard D., Aubry J. P., de Vries J. E., Spits H. The role of Ca2+ and Mg2+ in the cytotoxic T lymphocyte reaction and in the secretion of N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester-serine esterase by human T cell clones Journal of immunology (Baltimore, Md. 1989;142 (7):2173-2180 [PubMed]

1988

• Roncarolo M. G., Yssel H., Touraine J. L., Bacchetta R., Gebuhrer L., de Vries J. E., Spits H. Antigen recognition by MHC-incompatible cells of a human mismatched chimera Journal of experimental medicine 1988;168 (6):2139-2152 [PubMed]
• Roncarolo M. G., Yssel H., Touraine J. L., Betuel H., de Vries J. E., Spits H. Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera Journal of experimental medicine 1988;167 (5):1523-1534 [PubMed]
• Blanchard D., van Els C., Aubry J. P., de Vries J. E., Spits H. CD4 is involved in a post-binding event in the cytolytic reaction mediated by human CD4+ cytotoxic T lymphocyte clones Journal of immunology (Baltimore, Md. 1988;140 (6):1745-1752 [PubMed]
• Hochstenbach F., Parker C., McLean J., Gieselmann V., Band H., Bank I., Chess L., Spits H., Strominger J. L., Seidman J. G. Characterization of a third form of the human T cell receptor gamma/delta Journal of experimental medicine 1988;168 (2):761-776 [PubMed]
• Baer R., Boehm T., Yssel H., Spits H., Rabbitts T. H. Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments EMBO journal 1988;7 (6):1661-1668 [PubMed]
• van Seventer G. A., Spits H., Yssel H., Melief C. J., Ivanyi P. Differential recognition by human cytotoxic T cell clones of human M1 fibroblasts transfected with an HLA-B7 gene (JY150) suggests the existence of two different HLA-B7 alleles in the cell line JY (HLA-A2,2;B7,7;Cw-,-;DR4,w6) Journal of immunology (Baltimore, Md. 1988;141 (2):417-422 [PubMed]
• Satyanarayana K., Hata S., Devlin P., Roncarolo M. G., de Vries J. E., Spits H., Strominger J. L., Krangel M. S. Genomic organization of the human T-cell antigen-receptor alpha/delta locus Proceedings of the National Academy of Sciences of the United States of America 1988;85 (21):8166-8170 [PubMed]
• Pène J., Rousset F., Brière F., Chrétien I., Paliard X., Banchereau J., Spits H., de Vries J. E. IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma Journal of immunology (Baltimore, Md. 1988;141 (4):1218-1224 [PubMed]
• Pène J., Rousset F., Brière F., Chrétien I., Bonnefoy J. Y., Spits H., Yokota T., Arai N., Arai K., Banchereau J. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2 Proceedings of the National Academy of Sciences of the United States of America 1988;85 (18):6880-6884 [PubMed]
• Spits H., Yssel H., Paliard X., Kastelein R., Figdor C., de Vries J. E. IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures Journal of immunology (Baltimore, Md. 1988;141 (1):29-36 [PubMed]
• Paliard X., Malefijt R. W., de Vries J. E., Spits H. Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones Nature 1988;335 (6191):642-644 [PubMed]
• Yokota T., Arai N., de Vries J., Spits H., Banchereau J., Zlotnik A., Rennick D., Howard M., Takebe Y., Miyatake S. Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells Immunological reviews 1988;102:137-187 [PubMed]
• van Seventer G. A., van Lier R. A., Kuijpers K. C., Spits H., Melief C. J. Regulatory role of the CD8 antigen in both CD3 and CD2 monoclonal antibody-induced nonspecific cytotoxicity of class I- and class II-allospecific cytotoxic T cell clones European journal of immunology 1988;18 (12):1973-1978 [PubMed]
• Paliard X., de Waal Malefijt R., Yssel H., Blanchard D., Chrétien I., Abrams J., de Vries J., Spits H. Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones Journal of immunology (Baltimore, Md. 1988;141 (3):849-855 [PubMed]
• Bonnefoy J. Y., Guillot O., Spits H., Blanchard D., Ishizaka K., Banchereau J. The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens Journal of experimental medicine 1988;167 (1):57-72 [PubMed]
• Fleischer B., Sturm E., de Vries J. E., Spits H. Triggering of cytotoxic T lymphocytes and NK cells via the Tp103 pathway is dependent on the expression of the T cell receptor/CD3 complex Journal of immunology (Baltimore, Md. 1988;141 (4):1103-1107 [PubMed]

1987

• Borst J., de Vries E., Spits H., de Vries J. E., Boylston A. W., Matthews E. A. Complexity of T cell receptor recognition sites for defined alloantigens Journal of immunology (Baltimore, Md. 1987;139 (6):1952-1959 [PubMed]
• Yssel H., de Vries J. E., Borst J., Spits H. Distribution and functional analysis of a 120- to 130-kDa T-cell surface antigen Cellular immunology 1987;105 (1):161-173 [PubMed]
• Spits H., Yssel H., Takebe Y., Arai N., Yokota T., Lee F., Arai K., Banchereau J., de Vries J. E. Recombinant interleukin 4 promotes the growth of human T cells Journal of immunology (Baltimore, Md. 1987;139 (4):1142-1147 [PubMed]
• Yssel H., Aubry J. P., de Waal Malefijt R., de Vries J. E., Spits H. Regulation by anti-CD2 monoclonal antibody of the activation of a human T cell clone induced by anti-CD3 or anti-T cell receptor antibodies Journal of immunology (Baltimore, Md. 1987;139 (9):2850-2855 [PubMed]
• Blanchard D., van Els C., Borst J., Carrel S., Boylston A., de Vries J. E., Spits H. The role of the T cell receptor, CD8, and LFA-1 in different stages of the cytolytic reaction mediated by alloreactive T lymphocyte clones Journal of immunology (Baltimore, Md. 1987;138 (8):2417-2421 [PubMed]
• Alarcon B., de Vries J., Pettey C., Boylston A., Yssel H., Terhorst C., Spits H. The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone Proceedings of the National Academy of Sciences of the United States of America 1987;84 (11):3861-3865 [PubMed]

1986

• Borst J., Spits H., Voordouw A., de Vries E., Boylston A., de Vries J. E. A family of T-cell receptor molecules expressed on T-cell clones with different specificities for allomajor histocompatibility antigens Human immunology 1986;17 (4):426-442 [PubMed]
• Spits H., van Schooten W., Keizer H., van Seventer G., van de Rijn M., Terhorst C., de Vries J. E. Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells Science 1986;232 (4748):403-405 [PubMed]
• de Vries J. E., Keizer G. D., te Velde A. A., Voordouw A., Ruiter D., Rümke P., Spits H., Figdor C. G. Characterization of melanoma-associated surface antigens involved in the adhesion and motility of human melanoma cells International journal of cancer. Journal international du cancer 1986;38 (4):465-473 [PubMed]
• van Seventer G. A., van Lier R. A., Spits H., Ivanyi P., Melief C. J. Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones European journal of immunology 1986;16 (11):1363-1371 [PubMed]
• Haanen J. B., Ottenhoff T. H., Voordouw A., Elferink B. G., Klatser P. R., Spits H., de Vries R. R. HLA class-II-restricted Mycobacterium leprae-reactive T-cell clones from leprosy patients established with a minimal requirement for autologous mononuclear cells Scandinavian journal of immunology 1986;23 (1):101-108 [PubMed]
• Borst J., Boylston A. W., de Vries J. E., Spits H. Human T cell lines differing in phenotype and specificity are reactive with the same anti-idiotypic antibody Journal of immunology (Baltimore, Md. 1986;136 (2):601-608 [PubMed]
• Stam N. J., Spits H., Ploegh H. L. Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products Journal of immunology (Baltimore, Md. 1986;137 (7):2299-2306 [PubMed]
• Boylston A. W., Borst J., Yssel H., Blanchard D., Spits H., de Vries J. E. Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes Journal of immunology (Baltimore, Md. 1986;137 (2):741-744 [PubMed]
• Yssel H., Blanchard D., Boylston A., de Vries J. E., Spits H. T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity European journal of immunology 1986;16 (10):1187-1193 [PubMed]
• Terhorst C., de Vries J., Georgopoulos K., Gold D., Oettgen H., Pettey C., Spits H., Ucker D., van den Elsen P., Wileman T. The T cell receptor/T3 complex Year in immunology 1986;2:245-253 [PubMed]

1985

• Spits H., Yssel H., Leeuwenberg J., de Vries J. E. Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3 European journal of immunology 1985;15 (1):88-91 [PubMed]
• Keizer G. D., Borst J., Figdor C. G., Spits H., Miedema F., Terhorst C., de Vries J. E. Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95 European journal of immunology 1985;15 (11):1142-1148 [PubMed]
• Spits H., Borst J., Tax W., Capel P. J., Terhorst C., de Vries J. E. Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen Journal of immunology (Baltimore, Md. 1985;135 (3):1922-1928 [PubMed]
• Leeuwenberg J. F., Spits H., Tax W. J., Capel P. J. Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies Journal of immunology (Baltimore, Md. 1985;134 (6):3770-3775 [PubMed]
• Bosch M. L., Schreuder G. M., Spits H., Termijtelen A., Tilanus M. G., Giphart M. J. Polymorphisms within the HLA-DRw6 haplotype. I. Restriction fragment length variation and its correlation with serology Journal of immunology (Baltimore, Md. 1985;134 (5):3212-3217 [PubMed]
• Spits H., Yssel H., Voordouw A., de Vries J. E. The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens Journal of immunology (Baltimore, Md. 1985;134 (4):2294-2298 [PubMed]

1984

• Breuning M. H., Spits H., de Vries J. E., Iványi P. A cloned cytotoxic T-lymphocyte (CTL) line recognizing a subtype of HLA B27 Human immunology 1984;9 (4):231-242 [PubMed]
• Yssel H., Spits H., de Vries J. E. A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells Journal of experimental medicine 1984;160 (1):239-254 [PubMed]
• Miedema F., Tetteroo P. A., Hesselink W. G., Werner G., Spits H., Melief C. J. Both Fc receptors and lymphocyte-function-associated antigen 1 on human T gamma lymphocytes are required for antibody-dependent cellular cytotoxicity (killer cell activity) European journal of immunology 1984;14 (6):518-523 [PubMed]
• de Vries J. E., Spits H. Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity Journal of immunology (Baltimore, Md. 1984;132 (1):510-519 [PubMed]
• Bernabeu C., Maziarz R., Spits H., de Vries J., Burakoff S. J., Terhorst C. Coexpression of the human HLA-A2 or HLA-B7 heavy chain gene and human beta 2-microglobulin gene in L cells Journal of immunology (Baltimore, Md. 1984;133 (6):3188-3194 [PubMed]
• Arnaout M. A., Spits H., Terhorst C., Pitt J., Todd R. F. Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes Journal of clinical investigation 1984;74 (4):1291-1300 [PubMed]
• Spits H., Borst J., Giphart M., Coligan J., Terhorst C., de Vries J. E. HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes European journal of immunology 1984;14 (4):299-304 [PubMed]
• van de Rijn M., Bernabeu C., Royer-Pokora B., Weiss J., Seidman J. G., de Vries J., Spits H., Terhorst C. Recognition of HLA-A2 by cytotoxic T lymphocytes after DNA transfer into human and murine cells Science 1984;226 (4678):1083-1085 [PubMed]
• Yssel H., de Vries J. E., Koken M., van Blitterswijk W., Spits H. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones Journal of immunological methods 1984;72 (1):219-227 [PubMed]
• Taketani S., Krangel M. S., Spits H., de Vries J., Strominger J. L. Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes Journal of immunology (Baltimore, Md. 1984;133 (2):816-821 [PubMed]

1983

• Spits H., Keizer G., Borst J., Terhorst C., Hekman A., de Vries J. E. Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines Hybridoma (2005) 1983;2 (4):423-437 [PubMed]
• Snow P., Spits H., de Vries J., Terhorst C. Comparison of target antigens of monoclonal reagents OKT5, OKT8, and Leu2A, which inhibit effector function of human cytotoxic T lymphocytes Hybridoma (2005) 1983;2 (2):187-199 [PubMed]
• Bernabeu C., Finlay D., van de Rijn M., Maziarz R. T., Biro P. A., Spits H., de Vries J., Terhorst C. P. Expression of the major histocompatibility antigens HLA-A2 and HLA-B7 by DNA-mediated gene transfer Journal of immunology (Baltimore, Md. 1983;131 (4):2032-2037 [PubMed]
• Spits H., Ijssel H., Thompson A., de Vries J. E. Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci Journal of immunology (Baltimore, Md. 1983;131 (2):678-683 [PubMed]
• de Vries J. E., Vyth-Dreese F. A., Figdor C. G., Spits H., Leemans J. M., Bont W. S. Induction of phenotypic differentiation, interleukin 2 production, and PHA responsiveness of "immature" human thymocytes by interleukin 1 and phorbol ester Journal of immunology (Baltimore, Md. 1983;131 (1):201-206 [PubMed]
• Terhorst C., Borst J., Lerch P., van de Rijn M., Snow P., Spits H., de Vries J. Structural and functional aspects of the T-cell differentiation antigens T3, T6, and T8 Haematology and blood transfusion 1983;28:440-446 [PubMed]
• Borst J., Spits H., de Vries J., Pessano S., Rovera G., Terhorst C. Target antigen of monoclonal reagent S5.7: comparison with T3 antigen Hybridoma (2005) 1983;2 (3):265-274 [PubMed]

1982

• Spits H., Ijssel H., Terhorst C., de Vries J. E. Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity Journal of immunology (Baltimore, Md. 1982;128 (1):95-99 [PubMed]
• Spits H., Breuning M., Ivanyi P., Russo C., de Vries J. E. In vitro-isolated human cytotoxic T-lymphocyte clones detect variations in serologically defined HLA antigens Immunogenetics 1982;16 (6):503-512 [PubMed]
• Figdor C. G., Vyth-Dreese F. A., Bont W. S., Spits H., de Vries J. E. Isolation of human thymocytes differing in maturation state and function by centrifugal elutriation Thymus 1982;4 (4):243-256 [PubMed]
• de Vries J. E., Vyth-Dreese F. A., van der Hulst R., Sminia P., Figdor C. G., Bont W. S., Spits H. The replacement of monocytes and interleukin-1 by phorbol ester in lectin-induced proliferation of human thymocytes and T cells Immunobiology 1982;162 (2):103-115 [PubMed]
• Spits H., Borst J., Terhorst C., de Vries J. E. The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens Journal of immunology (Baltimore, Md. 1982;129 (4):1563-1569 [PubMed]

1981

• Spits H., de Vries J. E., Terhorst C. A permanent human cytotoxic T-cell line with high killing capacity against a lymphoblastoid B-cell line shows preference for HLA A, B target antigens and lacks spontaneous cytotoxic activity Cellular immunology 1981;59 (2):435-447 [PubMed]
• Spits H., de Vries J. E., Terhorst C. The cell-mediated lympholysis-inducing capacity of highly purified human monocytes and T lymphocytes in primary and secondary mixed leukocyte cultures Journal of immunology (Baltimore, Md. 1981;126 (6):2275-2278 [PubMed]

1977

• Opperdoes F. R., Borst P., Spits H. Particle-bound enzymes in the bloodstream form of Trypanosoma brucei European Journal of Biochemistry / FEBS 1977;76 (1):21-28 [PubMed]

1975

• Temmink J. H., Collard J. G., Spits H., Roos E. A comparative study of four cytochemical detection methods of concanavalin A binding sites on the cell membrane Experimental cell research 1975;92 (2):307-322 [PubMed]