Prof. J.J.P. Kastelein MD PhD publications

2021

• Landmesser Ulf, Haghikia Arash, Leiter Lawrence A., Wright R. Scott, Kallend David, Wijngaard Peter, Stoekenbroek Robert, Kastelein John Jp, Ray Kausik K. Effect of inclisiran, the small-interfering RNA against proprotein convertase subtilisin/kexin type 9, on platelets, immune cells, and immunological biomarkers: a pre-specified analysis from ORION-1 Cardiovascular research 2021;117 (1):284-291 [PubMed]
• Vallejo-Vaz Antonio J., Packard Chris J., Ference Brian A., Santos Raul D., Kastelein John J. P., Stein Evan A., Catapano Alberico L., Pedersen Terje R., Watts Gerald F., Ray Kausik K. LDL-cholesterol lowering and clinical outcomes in hypercholesterolemic subjects with and without a familial hypercholesterolemia phenotype: Analysis from the secondary prevention 4S trial Atherosclerosis 2021;320:1-9 [PubMed]
• Gibson C. Michael, Kastelein John J. P., Phillips Adam T., Aylward Philip E., Yee Megan K., Tendera Michal, Nicholls Stephen J., Pocock Stuart, Goodman Shaun G., Alexander John H., Lincoff A. Michael, Bode Christoph, Duffy Danielle, Heise Mark, Berman Gail, Mears Sojaita Jenny, Tricoci Pierluigi, Deckelbaum Lawrence I., Steg P. Gabriel, Ridker Paul, Mehran Roxana Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction American heart journal 2021;231:121-127 [PubMed]
• Ference Brian A., Kastelein John J. P., Catapano Alberico L. Update on Lipids and Lipoproteins - Reply JAMA 2021;325 (4):400-401 [PubMed]

2020

• Willeit Peter, Tschiderer Lena, Allara Elias, Reuber Kathrin, Seekircher Lisa, Gao Lu, Liao Ximing, Lonn Eva, Gerstein Hertzel C., Yusuf Salim, Brouwers Frank P., Asselbergs Folkert W., van Gilst Wiek, Anderssen Sigmund A., Grobbee Diederick E., Kastelein John J. P., Visseren Frank L. J., Ntaios George, Hatzitolios Apostolos I., Savopoulos Christos, Nieuwkerk Pythia T., Stroes Erik, Walters Matthew, Higgins Peter, Dawson Jesse, Gresele Paolo, Guglielmini Giuseppe, Migliacci Rino, Ezhov Marat, Safarova Maya, Balakhonova Tatyana, Sato Eiichi, Amaha Mayuko, Nakamura Tsukasa, Kapellas Kostas, Jamieson Lisa M., Skilton Michael, Blumenthal James A., Hinderliter Alan, Sherwood Andrew, Smith Patrick J., van Agtmael Michiel A., Reiss Peter, van Vonderen Marit G. A., Kiechl Stefan, Klingenschmid Gerhard, Sitzer Matthias, Stehouwer Coen D. A., de Groot Eric, Grooteman Muriel P. C. Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients Circulation 2020;142 (7):621-642 [PubMed]
• Defesche Joep C., Stefanutti Claudia, Langslet Gisle, Hopkins Paul N., Seiz Werner, Baccara-Dinet Marie T., Hamon Sara C., Banerjee Poulabi, Kastelein John J. P. Corrigendum to “Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia” J Clin Lipidol 11 (2017) 1338-1346 (Journal of Clinical Lipidology (2017) 11(6) (1338–1346.e7), (S1933287417304415), (10.1016/j.jacl.2017.08.016)) Journal of clinical lipidology 2020;14 (5):742 [PubMed]
• Luirink Ilse K. Diagnosis of familial hypercholesterolemia in children: Cascade screening from theory to practice 2020. 160p. ISBN 9789463614337. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Groothoff Jaap W., Kastelein John J. P.)
• Stokman Geurt, van den Hoek Anita M., Denker Thorbekk Ditte, Pieterman Elsbet J., Skovgård Veidal Sanne, Basta Brittany, Iruarrizaga-Lejarreta Marta, van der Hoorn José W., Verschuren Lars, Berbée Jimmy F. P., Rensen Patrick C. N., Skjæret Tore, Alonso Cristina, Feigh Michael, Kastelein John J. P., Friedman Scott L., Princen Hans M. G., Fraser David A. Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative Liver international 2020;40 (11):2860-2876 [PubMed]
• Nicholls Stephen J., Lincoff A. Michael, Garcia Michelle, Bash Dianna, Ballantyne Christie M., Barter Philip J., Davidson Michael H., Kastelein John J. P., Koenig Wolfgang, McGuire Darren K., Mozaffarian Dariush, Ridker Paul M., Ray Kausik K., Katona Brian G., Himmelmann Anders, Loss Larrye E., Rensfeldt Martin, Lundström Torbjörn, Agrawal Rahul, Menon Venu, Wolski Kathy, Nissen Steven E. Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial JAMA 2020;324 (22):2268-2280 [PubMed]
• Wright R. Scott, Collins Michael G., Stoekenbroek Robert M., Robson Richard, Wijngaard Peter L. J., Landmesser Ulf, Leiter Lawrence A., Kastelein John J. P., Ray Kausik K., Kallend David Effects of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Inclisiran: An Analysis of the ORION-7 and ORION-1 Studies Mayo Clinic proceedings. Mayo Clinic 2020;95 (1):77-89 [PubMed]
• Blom Dirk J., Harada-Shiba Mariko, Rubba Paolo, Gaudet Daniel, Kastelein John J. P., Charng Min-Ji, Pordy Robert, Donahue Stephen, Ali Shazia, Dong Yuping, Khilla Nagwa, Banerjee Poulabi, Baccara-Dinet Marie, Rosenson Robert S. Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial Journal of the American College of Cardiology 2020;76 (2):131-142 [PubMed]
• Raal Frederick J., Rosenson Robert S., Reeskamp Laurens F., Hovingh G. Kees, Kastelein John J. P., Rubba Paolo, Ali Shazia, Banerjee Poulabi, Chan Kuo-Chen, Gipe Daniel A., Khilla Nagwa, Pordy Robert, Weinreich David M., Yancopoulos George D., Zhang Yi, Gaudet Daniel Evinacumab for Homozygous Familial Hypercholesterolemia New England journal of medicine 2020;383 (8):711-720 [PubMed]
• Santos Raul D., Ruzza Andrea, Hovingh G. Kees, Wiegman Albert, Mach François, Kurtz Christopher E., Hamer Andrew, Bridges Ian, Bartuli Andrea, Bergeron Jean, Szamosi Tamás, Santra Saikat, Stefanutti Claudia, Descamps Olivier S., Greber-Platzer Susanne, Luirink Ilse, Kastelein John J. P., Gaudet Daniel Evolocumab in pediatric heterozygous familial hypercholesterolemia New England journal of medicine 2020;383 (14):1317-1327 [PubMed]
• Kastelein John J. P., Reeskamp Laurens F., Hovingh G. Kees Familial Hypercholesterolemia: The Most Common Monogenic Disorder in Humans Journal of the American College of Cardiology 2020;75 (20):2567-2569 [PubMed]
• Raal Frederick J., Kallend David, Ray Kausik K., Turner Traci, Koenig Wolfgang, Wright R. Scott, Wijngaard Peter L. J., Curcio Danielle, Jaros Mark J., Leiter Lawrence A., Kastelein John J. P. Inclisiran for the treatment of heterozygous familial hypercholesterolemia New England journal of medicine 2020;382 (16):1520-1530 [PubMed]
• Cupido Arjen J., Kastelein John J. P. Inclisiran for the treatment of hypercholesterolaemia: implications and unanswered questions from the ORION trials Cardiovascular research 2020;116 (11):e136-e139 [PubMed]
• Ference Brian A., Kastelein John J. P., Catapano Alberico L. Lipids and Lipoproteins in 2020 JAMA 2020;324 (6):595-596 [PubMed]
• Moriarty Patrick M., Gorby Lauryn K., Stroes Erik S., Kastelein John P., Davidson Michael, Tsimikas Sotirios Lipoprotein(a) and Its Potential Association with Thrombosis and Inflammation in COVID-19: a Testable Hypothesis Current atherosclerosis reports 2020;22 (9) [PubMed]
• Roth Eli M., Kastelein John J. P., Cannon Christopher P., Farnier Michel, McKenney James M., DiCioccio A. Thomas, Brunet Aurélie, Manvelian Garen, Sasiela William J., Baccara-Dinet Marie T., Zhao Jian, Robinson Jennifer G. Pharmacodynamic relationship between PCSK9, alirocumab, and LDL-C lowering in the ODYSSEY CHOICE I trial Journal of clinical lipidology 2020;14 (5):707-719 [PubMed]
• Ray Kausik K., Wright R. Scott, Kallend David, Koenig Wolfgang, Leiter Lawrence A., Raal Frederick J., Bisch Jenna A., Richardson Tara, Jaros Mark, Wijngaard Peter L. J., Kastelein John J. P. Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol New England journal of medicine 2020;382 (16):1507-1519 [PubMed]

2019

• Luirink Ilse K., Wiegman Albert, Kusters D. Meeike, Hof Michel H., Groothoff Jaap W., de Groot Eric, Kastelein John J. P., Hutten Barbara A. 20-Year follow-up of statins in children with familial hypercholesterolemia New England journal of medicine 2019;381 (16):1547-1556 [PubMed]
• Mani Preethi, Puri Rishi, Schwartz Gregory G., Nissen Steven E., Shao Mingyuan, Kastelein John J. P., Menon Venu, Lincoff A. Michael, Nicholls Stephen J. Association of Initial and Serial C-Reactive Protein Levels with Adverse Cardiovascular Events and Death after Acute Coronary Syndrome: A Secondary Analysis of the VISTA-16 Trial JAMA cardiology 2019;4 (4):314-320 [PubMed]
• Ference Brian A., Kastelein John J. P., Ray Kausik K., Ginsberg Henry N., Chapman M. John, Packard Chris J., Laufs Ulrich, Oliver-Williams Clare, Wood Angela M., Butterworth Adam S., di Angelantonio Emanuele, Danesh John, Nicholls Stephen J., Bhatt Deepak L., Sabatine Marc S., Catapano Alberico L. Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants with Risk of Coronary Heart Disease JAMA 2019;321 (4):364-373 [PubMed]
• O'Dea Louis St L., Macdougall James, Alexander Veronica J., Digenio Andres, Hubbard Brant, Arca Marcello, Moriarty Patrick M., Kastelein John J. P., Bruckert Eric, Soran Handrean, Witztum Joseph L., Hegele Robert A., Gaudet Daniel Differentiating Familial Chylomicronemia Syndrome from Multifactorial Severe Hypertriglyceridemia by Clinical Profiles Journal of the Endocrine Society 2019;3 (12):2397-2410 [PubMed]
• Ray Kausik K., Stoekenbroek Robert M., Kallend David, Nishikido Toshiyuki, Leiter Lawrence A., Landmesser Ulf, Wright R. Scott, Wijngaard Peter L. J., Kastelein John J. P. Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial JAMA cardiology 2019;4 (11):1067-1075 [PubMed]
• Kastelein John J. P., Stroes Erik S. G. FISHing for the miracle of eicosapentaenoic acid New England journal of medicine 2019;380 (1):89-90 [PubMed]
• Leiter Lawrence A., Teoh Hwee, Kallend David, Scott Wright R., Landmesser Ulf, Wijngaard Peter L. J., Kastelein John J. P., Ray Kausik K. Inclisiran lowers LDL-C and PCSK9 irrespective of diabetes status: The ORION-1 randomized clinical trial Diabetes care 2019;42 (1):173-176 [PubMed]
• Kastelein John J. P. Loket Gentherapie Nederlands tijdschrift voor geneeskunde 2019;163 (50) [PubMed]
• Ference Brian A., Ray Kausik K., Catapano Alberico L., Ference Thatcher B., Burgess Stephen, Neff David R., Oliver-Williams Clare, Wood Angela M., Butterworth Adam S., di Angelantonio Emanuele, Danesh John, Kastelein John J. P., Nicholls Stephen J. Mendelian randomization study of ACLY and cardiovascular disease New England journal of medicine 2019;380 (11):1033-1042 [PubMed]
• Larsen Lars E., Stoekenbroek Robert M., Kastelein John J. P., Holleboom Adriaan G. Moving Targets: Recent Advances in Lipid-Lowering Therapies Arteriosclerosis, thrombosis, and vascular biology 2019;39 (3):349-359 [PubMed]
• Robinson Jennifer G., Farnier Michel, Kastelein John J. P., Roth Eli M., Taskinen Marja-Riitta, Colhoun Helen M., Brunet Aurelie, DiCioccio A. Thomas, Lecorps Guillaume, Pordy Robert, Baccara-Dinet Marie T., Cannon Christopher P. Relationship between alirocumab, PCSK9, and LDL-C levels in four phase 3 ODYSSEY trials using 75 and 150 mg doses Journal of clinical lipidology 2019;13 (6):979–988.e10 [PubMed]
• Reeskamp Laurens F., Kastelein John J. P., Moriarty Patrick M., Duell P. Barton, Catapano Alberico L., Santos Raul D., Ballantyne Christie M. Safety and efficacy of mipomersen in patients with heterozygous familial hypercholesterolemia Atherosclerosis 2019;280:109-117 [PubMed]
• Gibson C. Michael, Kerneis Mathieu, Yee Megan K., Daaboul Yazan, Korjian Serge, Mehr Ali Poyan, Tricoci Pierluigi, Alexander John H., Kastelein John J. P., Mehran Roxana, Bode Christoph, Lewis Basil S., Mehta Ravindra, Duffy Danielle, Feaster John, Halabi Majdi, Angiolillo Dominick J., Duerschmied Daniel, Ophuis Ton Oude, Merkely Bela The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction American heart journal 2019;208:81-90 [PubMed]
• Gaudet Daniel, Durst Ronen, Lepor Norman, Bakker-Arkema Rebecca, Bisgaier Charles, Masson Liz, Golden Lee, Kastelein John J., Hegele Robert A., Stein Evan Usefulness of Gemcabene in Homozygous Familial Hypercholesterolemia (from COBALT-1) American journal of cardiology 2019;124 (12):1876-1880 [PubMed]

2018

• Hartgers Merel L., Besseling Joost, Stroes Erik S., Wittekoek Janneke, Rutten Joost H. W., de Graaf Jacqueline, Visseren Frank L. J., Imholz Ben P. M., Roeters van Lennep Jeanine E., Huijgen Roeland, Kastelein John J. P., Hovingh G. Kees Achieved LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia: A model that explores the efficacy of conventional and novel lipid-lowering therapy Journal of clinical lipidology 2018;12 (4):972-980.e1 [PubMed]
• Hartgers Merel L., Defesche Joep C., Langslet Gisle, Hopkins Paul N., Kastelein John J. P., Baccara-Dinet Marie T., Seiz Werner, Hamon Sara, Banerjee Poulabi, Stefanutti Claudia Alirocumab efficacy in patients with double heterozygous, compound heterozygous, or homozygous familial hypercholesterolemia Journal of clinical lipidology 2018;12 (2):390-396.e8 [PubMed]
• Nicholls Stephen J., Lincoff A. Michael, Bash Dianna, Ballantyne Christie M., Barter Philip J., Davidson Michael H., Kastelein John J. P., Koenig Wolfgang, McGuire Darren K., Mozaffarian Dariush, Pedersen Terje R., Ridker Paul M., Ray Kausik, Karlson Björn W., Lundström Torbjörn, Wolski Kathy, Nissen Steven E. Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial Clinical cardiology 2018;41 (10):1281-1288 [PubMed]
• Ridker Paul M., Rose Lynda M., Kastelein John J. P., Santos Raul D., Wei Caimiao, Revkin James, Yunis Carla, Tardif Jean-Claude, Shear Charles L. Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab Journal of clinical lipidology 2018;12 (4):958-965 [PubMed]
• Sturm Amy C., Knowles Joshua W., Gidding Samuel S., Ahmad Zahid S., Ahmed Catherine D., Ballantyne Christie M., Baum Seth J., Bourbon Mafalda, Carrié Alain, Cuchel Marina, de Ferranti Sarah D., Defesche Joep C., Freiberger Tomas, Hershberger Ray E., Hovingh G. Kees, Karayan Lala, Kastelein Johannes Jacob Pieter, Kindt Iris, Lane Stacey R., Leigh Sarah E., Linton MacRae F., Mata Pedro, Neal William A., Nordestgaard B. rge G., Santos Raul D., Harada-Shiba Mariko, Sijbrands Eric J., Stitziel Nathan O., Yamashita Shizuya, Wilemon Katherine A., Ledbetter David H., Rader Daniel J. Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel Journal of the American College of Cardiology 2018;72 (6):662-680 [PubMed]
• Ray Kausik K., Stoekenbroek Robert M., Kallend David, Leiter Lawrence A., Landmesser Ulf, Wright R. Scott, Wijngaard Peter, Kastelein John J. P. Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins Circulation 2018;138 (13):1304-1316 [PubMed]
• Arsenault Benoit J., Petrides Francine, Tabet Fatiha, Bao Weihang, Hovingh G. Kees, Boekholdt S. Matthijs, Ramin-Mangata Stéphane, Meilhac Olivier, DeMicco David, Rye Kerry-Anne, Waters David D., Kastelein John J. P., Barter Philip, Lambert Gilles Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk Journal of clinical lipidology 2018;12 (1):130-136 [PubMed]
• Nicholls Stephen J., Puri Rishi, Anderson Todd, Ballantyne Christie M., Cho Leslie, Kastelein John J. P., Koenig Wolfgang, Somaratne Ransi, Kassahun Helina, Yang Jingyuan, Wasserman Scott M., Honda Satoshi, Shishikura Daisuke, Scherer Daniel J., Borgman Marilyn, Brennan Danielle M., Wolski Kathy, Nissen Steven E. Effect of Evolocumab on Coronary Plaque Composition Journal of the American College of Cardiology 2018;72 (17):2012-2021 [PubMed]
• Nicholls Stephen J., Puri Rishi, Ballantyne Christie M., Jukema J. Wouter, Kastelein John J. P., Koenig Wolfgang, Wright R. Scott, Kallend David, Wijngaard Peter, Borgman Marilyn, Wolski Kathy, Nissen Steven E. Effect of infusion of high-density lipoprotein mimetic containing recombinant apolipoprotein A-I Milano on coronary disease in patients with an acute coronary syndrome in the MILANO-PILOT trial: A randomized clinical trial JAMA cardiology 2018;3 (9):806-814 [PubMed]
• Nicholls Stephen J., Andrews Jordan, Kastelein John J. P., Merkely Bela, Nissen Steven E., Ray Kausik K., Schwartz Gregory G., Worthley Stephen G., Keyserling Connie, Dasseux Jean-Louis, Griffith Liddy, Kim Susan W., Janssan Alex, di Giovanni Giuseppe, Pisaniello Anthony D., Scherer Daniel J., Psaltis Peter J., Butters Julie Effect of serial infusions of CER-001, a pre-β High-density lipoprotein mimetic, on coronary atherosclerosis in patients following acute coronary syndromes in the CER-001 atherosclerosis regression acute coronary syndrome trial: A randomized clinical trial JAMA cardiology 2018;3 (9):815-822 [PubMed]
• Harada-Shiba Mariko, Kastelein John J. P., Hovingh G. Kees, Ray Kausik K., Ohtake Akira, Arisaka Osamu, Ohta Takao, Okada Tomoo, Suganami Hideki, Wiegman Albert Efficacy and Safety of Pitavastatin in Children and Adolescents with Familial Hypercholesterolemia in Japan and Europe Journal of atherosclerosis and thrombosis 2018;25 (5):422-429 [PubMed]
• Kaasenbrood Lotte, Ray Kausik K., Boekholdt S. Matthijs, Smulders Yvo M., LaRosa John C., Kastelein John J. P., van der Graaf Yolanda, Dorresteijn Johannes A. N., Visseren Frank L. J. Estimated individual lifetime benefit from PCSK9 inhibition in statin-treated patients with coronary artery disease Heart (British Cardiac Society) 2018;104 (20):1699-1705 [PubMed]
• Stoekenbroek Robert M., Kallend David, Wijngaard Peter Lj, Kastelein John Jp Inclisiran for the treatment of cardiovascular disease: The ORION clinical development program Future cardiology 2018;14 (6):433-442 [PubMed]
• Vallejo-Vaz Antonio J., Marco Martina De, Stevens Christophe A. T., Akram Asif, Freiberger Tomas, Hovingh G. Kees, Kastelein John J. P., Mata Pedro, Raal Frederick J., Santos Raul D., Soran Handrean, Watts Gerald F., Abifadel Marianne, Aguilar-Salinas Carlos A., Al-Khnifsawi Mutaz, Alkindi Fahad A., Alnouri Fahad, Alonso Rodrigo, Al-Rasadi Khalid, Al-Sarraf Ahmad, Ashavaid Tester F., Binder Christoph J., Bogsrud Martin P., Bourbon Mafalda, Bruckert Eric, Chlebus Krzysztof, Corral Pablo, Descamps Olivier, Durst Ronen, Ezhov Marat, Fras Zlatko, Genest Jacques, Groselj Urh, Harada-Shiba Mariko, Kayikcioglu Meral, Lalic Katarina, Lam Carolyn S. P., Latkovskis Gustavs, Laufs Ulrich, Liberopoulos Evangelos, Lin Jie, Maher Vincent, Majano Nelson, Marais A. David, März Winfried, Mirrakhimov Erkin, Miserez André R., Mitchenko Olena, Nawawi Hapizah M., Nordestgaard B. rge G., Paragh György, Petrulioniene Zaneta, Pojskic Belma, Postadzhiyan Arman, Reda Ashraf, Reiner Željko, Sadoh Wilson E., Sahebkar Amirhossein, Shehab Abdullah, Shek Aleksander B., Stoll Mario, Su Ta-Chen, Subramaniam Tavintharan, Susekov Andrey V., Symeonides Phivos, Tilney Myra, Tomlinson Brian, Truong Thanh-Huong, Tselepis Alexandros D., Tybjærg-Hansen Anne, Vázquez-Cárdenas Alejandra, Viigimaa Margus, Vohnout Branislav, Widén Elisabeth, Yamashita Shizuya, Banach Maciej, Gaita Dan, Jiang Lixin, Nilsson Lennart, Santos Lourdes E., Schunkert Heribert, Tokgözoğlu Lale, Car Josip, Catapano Alberico L., Ray Kausik K., Akram Asif, Car Josip, Marco Martina De, Ray Kausik K., Stevens Christophe A. T., Vallejo-Vaz Antonio J., Corral Pablo, Schreier Laura, Watts Gerald F., Pang Jing, Binder Christoph J., Dieplinger Hans, Hanauer-Mader Gabriele, Descamps Olivier, Desutter Johan, Langlois Michel, Mertens Ann, Rietzschel Ernst, Wallemacq Caroline, Pojskic Belma, Isakovic Dzenana, Dzankovic Amra M., Obralija Jasna, Pojskic Lamija, Sisic Ibrahim, Stimjanin Ena, Torlak Vildana A., Santos Raul D., Jannes Cinthia E., Krieger Jose E., Pereira Alexandre C., Postadzhiyan Arman, Genest Jacques, Ruel Isabelle, Alonso Rodrigo, Asenjo Sylvia, Cuevas Ada, Lin Jie, Jiang Lixin, Reiner Željko, Pećin Ivan, Symeonides Phivos, Miltiadous George, Panayiotou Andrie G., Freiberger Tomas, Vrablik Michal, Nordestgaard B. rge G., Tybjærg-Hansen Anne, Benn Marianne, Reda Ashraf, Viigimaa Margus, Heinsar Silver, Widén Elisabeth, Bruckert Eric, Béliard S., Laufs Ulrich, März Winfried, Schunkert Heribert, Gouni-Berthold Ioanna, Hengstenberg Wibke, Julius Ulrich, Kassner Ursula, Klose Gerald, König Christel, König Wolfgang, Otte Britta, Parhofer Klaus, Schatz Ulrike, Schmidt Nina, Steinhagen-Thiessen Elisabeth, Vogt Anja, Liberopoulos Evangelos, Tselepis Alexandros D., Antza Christina, Athyros Vasilios, Bilianou Eleni, Boufidou Amalia, Chrousos George, Elisaf Moses, Garoufi Anastasia, Katsiki Niki, Kolovou Genovefa, Kotsis Vasilios, Rallidis Loukianos, Rizos Christos, Skalidis Emmanouel, Skoumas Ioannis, Tziomalos Kostantinos, Tomlinson Brian, Paragh György, Ashavaid Tester F., Shawney J. P. S., Sahebkar Amirhossein, Abbaszadegan Mohammad R., Aminzadeh Majid, Hosseini Sousan, Mobini Moein, Vakili Rahim, Zaeri Hossein, Al-Khnifsawi Mutaz, Maher Vincent, Agar Ruth, Boran Gerard, Colwell Nial, Crowley Vivion, Durkin Maeve, Griffin Damian, Kelly Michael, Rakovac-Tisdall Ana, Durst Ronen, Bitzur Rafael, Cohen Hofit, Eliav Osnat, Ellis Avishay, Gavish Dov, Harats Dror, Henkin Yaacov, Knobler Hila, Leavit Leah, Leitersdorf Eran, Rubinstein Ardon, Schurr Daniel, Shpitzen Shoshi, Szalat Auryan, Catapano Alberico L., Arca Marcello, Averna Maurizio, Bertolini Stefano, Calandra Sebastiano, Tarugi Patrizia, Harada-Shiba Mariko, Yamashita Shizuya, Al-Sarraf Ahmad, Mirrakhimov Erkin, Latkovskis Gustavs, Erglis Andrejs, Gilis Dainus, Nesterovics Georgijs, Saripo Vita, Upena-Roze Arta, Abifadel Marianne, Elbitar Sandy, Jambart S. lim, Khoury Petra El, Petrulioniene Zaneta, Gargalskaite Urte, Kutkiene Sandra, Nawawi Hapizah M., Al-Khateeb Alyaa, An Chua Y., Ismail Zaliha, Kasim Sazzli, Ibrahim Khairul S., Radzi Ahmad B. M., Kasim Noor A., Nor Noor S. M., Ramli Anis S., Razak Suraya A., Muid Suhaila, Rosman Azhari, Sanusi Abd R., Razman Aimi Z., Nazli Sukma A., Kek Teh L., Tilney Myra, Azzopardi Conrad, Aguilar Salinas Carlos A., Vázquez-Cárdenas N. Alejandra, Galán Gabriela, Magaña-Torres M. T., Martagon Alexandro, Mehta Roopa, Hovingh G. Kees, Kastelein John J. P., Wittekoek M. E., Sadoh Wilson E., Isara Alphonsus R., Obaseki Darlington E., Ohenhen Oluwatoyin A., Bogsrud Martin P., Holven Kirsten B., Al-Rasadi Khalid, Santos Lourdes E., Banach Maciej, Chlebus Krzysztof, Gruchała Marcin, Baranowska Marlena, Borowiec-Wolny Justyna, Gilis-Malinowska Natasza, Michalska-Grzonkowska Aleksandra, Pajkowski Marcin, Parczewska Aleksandra, Romanowska-Kocejko Marzena, Stróżyk Aneta, Żarczyńska-Buchowiecka Marta, Kleinschmidt Mariola, Bourbon Mafalda, Alves Ana C., Medeiros Ana M., Alkindi Fahad A., Gaita Dan, Ezhov Marat, Susekov Andrey V., Ershova Alexandra, Korneva Victoria, Kuznetsova Tatiana, Malyshev Pavel, Meshkov Alexey, Rozhkova Tatiana, Alnouri Fahad, Lalic Katarina, Rajkovic Natasa, Popovic Ljiljana, Lukac Sandra S., Stosic Ljubica, Rasulic Iva, Lalic Nebojsa M., Subramaniam Tavintharan, Lam Carolyn S. P., Chua Terrance S. J., Ting Sharon P. L., Vohnout Branislav, Raslova Katarina, Fras Zlatko, Groselj Urh, Battelino Tadej, Cevc Matija, Jug Borut, Kovac Jernej, Podkrajsek Katarina T., Sustar Ursa, Trontelj Katja J., Marais David, Raal Frederick J., Mata Pedro, Isla Leopoldo Perez de, Nilsson Lennart, Miserez André R., Martin François J., Su Ta-Chen, Charng Ming-Ji, Chen Pei-Lung, Kayikçioglu Meral, Tokgözoğlu Lale, Mitchenko Olena, Shehab Abdullah, Soran Handrean, Stoll Mario, Dell’oca Nicolás, Fernández Graciela, Ressia Andrés, Reyes Ximena, Zelarayan Mario, Shek Aleksander B., Alieva Rano B., Hoshimov Shavkat U., Kurbanov Ravshanbek D., Nizamov Ulugbek I., Majano Nelson, Lima-Martínez Marcos M., Truong Thanh-Huong, Nguyen Mai-Ngoc Thi, Do Doan-Loi, Kim Ngoc-Thanh, le Hong-An, le Thanh-Tung Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) Atherosclerosis 2018;277:234-255 [PubMed]
• Stoekenbroek Robert M., Kastelein John J. P. Proprotein convertase subtilisin/kexin type 9: From genetics to clinical trials Current opinion in cardiology 2018;33 (3):269-275 [PubMed]
• Ridker Paul M., MacFadyen Jean G., Everett Brendan M., Libby Peter, Thuren Tom, Glynn Robert J., Ridker Paul M., MacFadyen Jean G., Everett Brendan M., Libby Peter, Thuren Tom, Glynn Robert J., Kastelein John, Koenig Wolfgang, Genest Jacques, Lorenzatti Alberto, Varigos John, Siostrzonek Peter, Sinnaeve Peter, Fonseca Francisco, Nicolau Jose, Gotcheva Nina, Yong Huo, Urina-Triana Miguel, Milicic Davor, Cifkova Renata, Vettus Riina, Anker Stephan D., Manolis Athanasios J., Wyss Fernando, Forster Tamas, Sigurdsson Axel, Pais Prem, Fucili Alessandro, Ogawa Hisao, Shimokawa Hiroaki, Veze Irina, Petrauskiene Birute, Salvador Leon, Cornel Jan Hein, Klemsdal Tor Ole, Medina Felix, Budaj Andrzej, Vida-Simiti Luminita, Kobalava Zhanna, Otasevic Petar, Pella Daniel, Lainscak Mitja, Seung Ki-Bae, Commerford Patrick Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial Lancet 2018;391 (10118):319-328 [PubMed]
• van Capelleveen Julian C., Lee Sang-Rok, Verbeek Rutger, Kastelein John J. P., Wareham Nicholas J., Stroes Erik S. G., Hovingh G. Kees, Khaw Kay-Tee, Boekholdt S. Matthijs, Witztum Joseph L., Tsimikas Sotirios Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study Journal of clinical lipidology 2018;12 (6):1493-1501.e11 [PubMed]
• Kusters D. Meeike, Braamskamp Marjet J. A. M., Langslet Gisle, McCrindle Brian W., Cassiman David, Francis Gordon A., Gagne Claude, Gaudet Daniel, Morrison Katherine M., Wiegman Albert, Turner Traci, Miller Elinor, Raichlen Joel, Martin Paul D., Stein Evan A., Kastelein John J. P., Hutten Barbara A. Response by Kusters et al to Letter Regarding Article, "Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label)" Circulation 2018;137 (6):641-642 [PubMed]
• Vallejo-Vaz Antonio J., Fayyad Rana, Boekholdt S. Matthijs, Hovingh G. Kees, Kastelein John J., Melamed Shari, Barter Philip, Waters David D., Ray Kausik K. Triglyceride-Rich Lipoprotein Cholesterol and Risk of Cardiovascular Events Among Patients Receiving Statin Therapy in the TNT Trial Circulation 2018;138 (8):770-781 [PubMed]

2017

• Ridker Paul M., Everett Brendan M., Thuren Tom, Macfadyen Jean G., Chang William H., Ballantyne Christie, Fonseca Francisco, Nicolau Jose, Koenig Wolfgang, Anker Stefan D., Kastelein John J. P., Cornel Jan H., Pais Prem, Pella Daniel, Genest Jacques, Cifkova Renata, Lorenzatti Alberto, Forster Tamas, Kobalava Zhanna, Vida-Simiti Luminita, Flather Marcus, Shimokawa Hiroaki, Ogawa Hisao, Dellborg Mikael, Rossi Paulo R. F., Troquay Roland P. T., Libby Peter, Glynn Robert J., Krum Henry, Varigos John, Siostrzonek Peter, Sinnaeve Peter, Gotcheva Nina, Yong Huo, Urina-Triana Miguel, Milicic Davor, Vettus Riina, Manolis Athanasios J., Wyss Fernando, Sigurdsson Axel, Fucili Alessandro, Veze Irina, Petrauskiene Birute, Salvador Leon, Klemsdal Tor Ole, Medina Felix, Budaj Andrzej, Otasevic Petar, Lainscak Mitja, Seung Ki-Bae Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease New England journal of medicine 2017;377 (12):1119-1131 [PubMed]
• van Capelleveen Julian C., Bernelot Moens Sophie J., Yang Xiaohong, Kastelein John J. P., Wareham Nicholas J., Zwinderman Aeilko H., Stroes Erik S. G., Witztum Joseph L., Hovingh G. Kees, Khaw Kay-Tee, Boekholdt S. Matthijs, Tsimikas Sotirios Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study Arteriosclerosis, thrombosis, and vascular biology 2017;37 (6):1206-1212 [PubMed]
• Ference Brian A., Kastelein John J. P., Ginsberg Henry N., Chapman M. John, Nicholls Stephen J., Ray Kausik K., Packard Chris J., Laufs Ulrich, Brook Robert D., Oliver-Williams Clare, Butterworth Adam S., Danesh John, Smith George Davey, Catapano Alberico L., Sabatine Marc S. Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk JAMA 2017;318 (10):947-956 [PubMed]
• van Capelleveen Julian C., Bochem Andrea E., Boekholdt S. Matthijs, Mora Samia, Hoogeveen Ron C., Ballantyne Christie M., Ridker Paul M., Sun Wensheng, Barter Philip J., Tall Alan R., Zwinderman Aeilko H., Kastelein John J. P., Wareham Nick J., Khaw Kay-Tee, Hovingh G. Kees Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study, and the Women's Health Study Journal of the American Heart Association 2017;6 (8) [PubMed]
• Stoekenbroek Robert M., Kastelein John J. P., Hovingh G. Kees Can we afford not to screen for FH? European heart journal 2017;38 (23):1840-1842 [PubMed]
• Ridker Paul M., Revkin James, Amarenco Pierre, Brunell Robert, Curto Madelyn, Civeira Fernando, Flather Marcus, Glynn Robert J., Gregoire Jean, Jukema J. Wouter, Karpov Yuri, Kastelein John J. P., Koenig Wolfgang, Lorenzatti Alberto, Manga Pravin, Masiukiewicz Urszula, Miller Michael, Mosterd Arend, Murin Jan, Nicolau Jose C., Nissen Steven, Ponikowski Piotr, Santos Raul D., Schwartz Pamela F., Soran Handrean, White Harvey, Wright R. Scott, Vrablik Michal, Yunis Carla, Shear Charles L., Tardif Jean-Claude Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients New England journal of medicine 2017;376 (16):1527-1539 [PubMed]
• Verbeek Rutger, Boyer Marjorie, Boekholdt S. Matthijs, Hovingh G. Kees, Kastelein John J. P., Wareham Nicholas, Khaw Kay-Tee, Arsenault Benoit J. Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report Arteriosclerosis, thrombosis, and vascular biology 2017;37 (1):43-48 [PubMed]
• Stoekenbroek Robert M., Kastelein John J. P. Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind? Nature reviews. Cardiology 2017;14 (8):445-446 [PubMed]
• Kastelein John J. P., Kereiakes Dean J., Cannon Christopher P., Bays Harold E., Minini Pascal, Lee L. Veronica, Maroni Jaman, Farnier Michel Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia Coronary artery disease 2017;28 (3):190-197 [PubMed]
• Braamskamp Marjet J. A. M., Langslet Gisle, McCrindle Brian W., Cassiman David, Francis Gordon A., Gagne Claude, Gaudet Daniel, Morrison Katherine M., Wiegman Albert, Turner Traci, Miller Elinor, Kusters D. Meeike, Raichlen Joel S., Martin Paul D., Stein Evan A., Kastelein John J. P., Hutten Barbara A. Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label) Circulation 2017;136 (4):359-366 [PubMed]
• Andrews Jordan, Janssan Alex, Nguyen Tracy, Pisaniello Anthony D., Scherer Daniel J., Kastelein John J. P., Merkely Bela, Nissen Steven E., Ray Kausik, Schwartz Gregory G., Worthley Stephen G., Keyserling Connie, Dasseux Jean-Louis, Butters Julie, Girardi Jacinta, Miller Rosemary, Nicholls Stephen J. Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study Cardiovascular diagnosis and therapy 2017;7 (1):45-51 [PubMed]
• Sjouke Barbara, Elbers Laura P. B., van Zaane Bregje, Kastelein John J. P., Hovingh G. Kees, Gerdes Victor E. A. Effects of Supra-Physiological Levothyroxine Dosages on Liver Parameters, Lipids and Lipoproteins in Healthy Volunteers: A Randomized Controlled Crossover Study Scientific reports 2017;7 (1) [PubMed]
• Kastelein John J. P., Hovingh G. Kees, Langslet Gisle, Baccara-Dinet Marie T., Gipe Daniel A., Chaudhari Umesh, Zhao Jian, Minini Pascal, Farnier Michel Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial hypercholesterolemia Journal of clinical lipidology 2017;11 (1):195-203 [PubMed]
• Defesche Joep C., Stefanutti Claudia, Langslet Gisle, Hopkins Paul N., Seiz Werner, Baccara-Dinet Marie T., Hamon Sara C., Banerjee Poulabi, Kastelein John J. P. Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia Journal of clinical lipidology 2017;11 (6):1338-1346 [PubMed]
• Stein Evan A., Dann Eldad J., Wiegman Albert, Skovby Flemming, Gaudet Daniel, Sokal Etienne, Charng Min-Ji, Mohamed Mafauzy, Luirink Ilse, Raichlen Joel S., Sundén Mattias, Carlsson Stefan C., Raal Frederick J., Kastelein John J. P. Efficacy of Rosuvastatin in Children With Homozygous Familial Hypercholesterolemia and Association With Underlying Genetic Mutations Journal of the American College of Cardiology 2017;70 (9):1162-1170 [PubMed]
• Sjouke Barbara Extreme phenotypes in hypercholesterolemia : From genotype to therapy 2017. 367p. ISBN 9789402804867. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Hovingh G. K.)
• Stoekenbroek Robert M., Kees Hovingh G., Kastelein John J. P. Homozygous familial hypercholesterolaemia: light at the end of the tunnel European heart journal 2017;39 (14):1169-1171 [PubMed]
• Ray Kausik K., Landmesser Ulf, Leiter Lawrence A., Kallend David, Dufour Robert, Karakas Mahir, Hall Tim, Troquay Roland P. T., Turner Traci, Visseren Frank L. J., Wijngaard Peter, Wright R. Scott, Kastelein John J. P. Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol New England journal of medicine 2017;376 (15):1430-1440 [PubMed]
• Ridker Paul M., Tardif Jean-Claude, Amarenco Pierre, Duggan William, Glynn Robert J., Jukema J. Wouter, Kastelein John J. P., Kim Albert M., Koenig Wolfgang, Nissen Steven, Revkin James, Rose Lynda M., Santos Raul D., Schwartz Pamela F., Shear Charles L., Yunis Carla Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab New England journal of medicine 2017;376 (16):1517-1526 [PubMed]
• Verbeek Rutger, Sandhu Manjinder S., Hovingh G. Kees, Sjouke Barbara, Wareham Nicholas J., Zwinderman Aeilko H., Kastelein John J. P., Khaw Kay-Tee, Tsimikas Sotirios, Boekholdt S. Matthijs Lipoprotein(a) Improves Cardiovascular Risk Prediction Based on Established Risk Algorithms Journal of the American College of Cardiology 2017;69 (11):1513-1515 [PubMed]
• Vallejo-Vaz Antonio J., Robertson Michele, Catapano Alberico L., Watts Gerald F., Kastelein John J., Packard Chris J., Ford Ian, Ray Kausik K. Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational Follow-Up Circulation 2017;136 (20):1878-1891 [PubMed]
• Bruikman Caroline S., Hovingh Gerard K., Kastelein John J. P. Molecular basis of familial hypercholesterolemia Current opinion in cardiology 2017;32 (3):262-266 [PubMed]
• Bruikman Caroline S., Stoekenbroek Robert M., Hovingh G. Kees, Kastelein John P. New Drugs for Atherosclerosis Canadian journal of cardiology 2017;33 (3):350-357 [PubMed]
• Cupido Arjen J., Reeskamp Laurens F., Kastelein John J. P. Novel lipid modifying drugs to lower LDL cholesterol Current opinion in lipidology 2017;28 (4):367-373 [PubMed]
• Sjouke Barbara, Yahya Reyhana, Tanck Michael W. T., Defesche Joep C., de Graaf Jacqueline, Wiegman Albert, Kastelein John J. P., Mulder Monique T., Hovingh G. Kees, Roeters van Lennep Jeanine E. Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia Journal of clinical lipidology 2017;11 (2):507-514 [PubMed]
• Bangalore Sripal, Fayyad Rana, Messerli Franz H., Laskey Rachel, Demicco David A., Kastelein John J. P., Waters David D. Relation of Variability of Low-Density Lipoprotein Cholesterol and Blood Pressure to Events in Patients With Previous Myocardial Infarction from the IDEAL Trial American journal of cardiology 2017;119 (3):379-387 [PubMed]
• Robinson Jennifer G., Rosenson Robert S., Farnier Michel, Chaudhari Umesh, Sasiela William J., Merlet Laurence, Miller Kathryn, Kastelein John J. P. Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab: Pooled Data From Randomized Trials Journal of the American College of Cardiology 2017;69 (5):471-482 [PubMed]
• Besseling Joost, Reitsma Johannes B., Gaudet Daniel, Brisson Diane, Kastelein John J. P., Hovingh G. Kees, Hutten Barbara A. Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia European heart journal 2017;38 (8):565-573 [PubMed]
• Ursoniu Sorin, Mikhailidis Dimitri P., Serban Maria-Corina, Penson Peter, Toth Peter P., Ridker Paul M., Ray Kausik K., Kees Hovingh G., Kastelein John J., Hernandez Adrian V., Manson JoAnn E., Rysz Jacek, Banach Maciej The effect of statins on cardiovascular outcomes by smoking status: A systematic review and meta-analysis of randomized controlled trials Pharmacological research 2017;122:105-117 [PubMed]
• Ray Kausik K., Kastelein John J. P. Time to change the SCORE? European heart journal 2017;38 (8):595-597 [PubMed]

2016

• Bangalore Sripal, Fayyad Rana, Kastelein John J., Laskey Rachel, Amarenco Pierre, Demicco David A., Waters David D. 2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis? American journal of medicine 2016;129 (4):384-391 [PubMed]
• Maiwald Stephanie, Motazacker Mahdi M., van Capelleveen Julian C., Sivapalaratnam Suthesh, van der Wal Allard C., van der Loos Chris, Kastelein John J. P., Ouwehand Willem H., Hovingh G. Kees, Trip Mieke D., van Buul Jaap D., Dallinga-Thie Geesje M. A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis European journal of human genetics 2016;24 (1):86-91 [PubMed]
• Sjouke Barbara, Tanck Michael W. T., Fouchier Sigrid W., Defesche Joep C., Hutten Barbara A., Wiegman Albert, Kastelein John J. P., Hovingh G. Kees Children with hypercholesterolemia of unknown cause: Value of genetic risk scores Journal of clinical lipidology 2016;10 (4):851-859 [PubMed]
• Besseling Joost, Huijgen Roeland, Martin Seth S., Hutten Barbara A., Kastelein John J. P., Hovingh G. Kees Clinical phenotype in relation to the distance-to-index-patient in familial hypercholesterolemia Atherosclerosis 2016;246:1-6 [PubMed]
• Gitt Anselm K., Lautsch Dominik, Ferrieres Jean, Kastelein John, Drexel Heinz, Horack Martin, Brudi Philippe, Vanneste Brecht, Bramlage Peter, Chazelle Francois, Sazonov Vasilisa, Ambegaonkar Baishali Contemporary data on low-density lipoprotein cholesterol target value attainment and distance to target in a cohort of 57,885 statin-treated patients by country and region across the world Data in brief 2016;9:616-620 [PubMed]
• Robinson Jennifer G., Huijgen Roeland, Ray Kausik, Persons Jane, Kastelein John J. P., Pencina Michael J. Determining When to Add Nonstatin Therapy: A Quantitative Approach Journal of the American College of Cardiology 2016;68 (22):2412-2421 [PubMed]
• Hovingh G. Kees, Kastelein John J. P. Diagnosis and Management of Individuals With Heterozygous Familial Hypercholesterolemia: Too Late and Too Little Circulation 2016;134 (10):710-712 [PubMed]
• Kaasenbrood Lotte, Boekholdt S. Matthijs, van der Graaf Yolanda, Ray Kausik K., Peters Ron J. G., Kastelein John J. P., Amarenco Pierre, LaRosa John C., Cramer Maarten J. M., Westerink Jan, Kappelle L. Jaap, de Borst Gert J., Visseren Frank L. J. Distribution of Estimated 10-Year Risk of Recurrent Vascular Events and Residual Risk in a Secondary Prevention Population Circulation 2016;134 (19):1419-1429 [PubMed]
• Sjouke Barbara, Defesche Joep C., Hartgers Merel L., Wiegman Albert, Roeters van Lennep Jeanine E., Kastelein John J., Hovingh G. Kees Double-heterozygous autosomal dominant hypercholesterolemia: Clinical characterization of an underreported disease Journal of clinical lipidology 2016;10 (6):1462-1469 [PubMed]
• Nicholls Stephen J., Puri Rishi, Anderson Todd, Ballantyne Christie M., Cho Leslie, Kastelein John J. P., Koenig Wolfgang, Somaratne Ransi, Kassahun Helina, Yang Jingyuan, Wasserman Scott M., Scott Robert, Ungi Imre, Podolec Jakub, Ophuis Antonius Oude, Cornel Jan H., Borgman Marilyn, Brennan Danielle M., Nissen Steven E. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial JAMA 2016;316 (22):2373-2384 [PubMed]
• Nicholls Stephen J., Puri Rishi, Wolski Kathy, Ballantyne Christie M., Barter Philip J., Brewer H. Bryan, Kastelein John J. P., Hu Bo, Uno Kiyoko, Kataoka Yu, Herrman Jean-Paul R., Merkely Bela, Borgman Marilyn, Nissen Steven E. Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial American journal of cardiovascular drugs 2016;16 (1):55-65 [PubMed]
• van Capelleveen Julian C., Kastelein John J. P., Zwinderman Aeilko H., van Deventer Sander J. H., Collins Heidi L., Adelman Steven J., Round Patrick, Ford John, Rader Daniel J., Hovingh G. Kees Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses Journal of clinical lipidology 2016;10 (5):1137-1144.e3 [PubMed]
• Stroes Erik, Guyton John R., Lepor Norman, Civeira Fernando, Gaudet Daniel, Watts Gerald F., Baccara-Dinet Marie T., Lecorps Guillaume, Manvelian Garen, Farnier Michel, Kostner K., Lehman S., Descamps O., Gheyle L., Mathieu C., Bergeron J., Elliott T., Girard G., Gupta A., Hoag G., Hove J., Jeppesen J., Kjærulf J. H., Klarlund K., Thomsen K. K., Basart D. C. G., Kooy A., Liem A., Swart H., Troquay R., van Het Hof-Wiersma J., Viergever P., Visseren F., Doughty R. N., Scott R., Calvo C., Díaz-Díaz J. L., Fuentes F., Gil-Extremera B., Jericó C., Matas Pericas L., Mediavilla Garcia J. D., Bolster D. E., Koren M., El Shahawy M., Vardi G., Weinstein D., Zuzarte K., Ginsberg Henry, Kastelein John J. P. Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study Journal of the American Heart Association 2016;5 (9):e003421 [PubMed]
• Arsenault Benoit J., Kohli Payal, Lambert Gilles, Demicco David A., Laskey Rachel, Messig Michael M., Kastelein John J. P., Waters David D. Emerging Cardiovascular Disease Biomarkers and Incident Diabetes Mellitus Risk in Statin-Treated Patients With Coronary Artery Disease (from the Treating to New Targets [TNT] Study) American journal of cardiology 2016;118 (4):494-498 [PubMed]
• Ridker Paul M., Amarenco Pierre, Brunell Robert, Glynn Robert J., Jukema J. Wouter, Kastelein John J. P., Koenig Wolfgang, Nissen Steven, Revkin James, Santos Raul D., Schwartz Pamela F., Yunis Carla, Tardif Jean-Claude Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) Lipid Lowering and SPIRE Cardiovascular Outcomes Trials American heart journal 2016;178:135-144 [PubMed]
• Kusters Meeke Familial hypercholesterolemia: Screening, treatment and follow-up from pregnancy into young adulthood 2016. 423p. ISBN 9789462332225. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Wijburg F. A.; Co-supervisors: Hutten B. A., Wiegman A.)
• Kastelein John J. P., Hallén Jonas, Vige Runar, Fraser David A., Zhou Rong, Hustvedt Svein Olaf, Orloff David G., Bays Harold E. Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia Cardiology 2016;135 (1):3-12 [PubMed]
• Bays Harold E., Hallén Jonas, Vige Runar, Fraser David, Zhou Rong, Hustvedt Svein Olaf, Orloff David G., Kastelein John J. P. Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial Journal of clinical lipidology 2016;10 (1):181-91.e1-2 [PubMed]
• Puri Rishi, Nissen Steven E., Somaratne Ransi, Cho Leslie, Kastelein John J. P., Ballantyne Christie M., Koenig Wolfgang, Anderson Todd J., Yang Jingyuan, Kassahun Helina, Wasserman Scott M., Scott Robert, Borgman Marilyn, Nicholls Stephen J. Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV) American heart journal 2016;176:83-92 [PubMed]
• Duell P. Barton, Santos Raul D., Kirwan Bridget-Anne, Witztum Joseph L., Tsimikas Sotirios, Kastelein John J. P. Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia Journal of clinical lipidology 2016;10 (4):1011-1021 [PubMed]
• Gitt Anselm K., Lautsch Dominik, Ferrieres Jean, Kastelein John, Drexel Heinz, Horack Martin, Brudi Philippe, Vanneste Brecht, Bramlage Peter, Chazelle Francois, Sazonov Vasilisa, Ambegaonkar Baishali Low-density lipoprotein cholesterol in a global cohort of 57,885 statin-treated patients Atherosclerosis 2016;255:200-209 [PubMed]
• Blom Dirk J., Fayad Zahi A., Kastelein John J. P., Larrey Dominique, Makris Lukas, Schwamlein Charles, Bloeden LeAnne, Underberg James LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design Journal of clinical lipidology 2016;10 (2):273-282 [PubMed]
• Postmus Iris, Warren Helen R., Trompet Stella, Arsenault Benoit J., Avery Christy L., Bis Joshua C., Chasman Daniel I., de Keyser Catherine E., Deshmukh Harshal A., Evans Daniel S., Feng QiPing, Li Xiaohui, Smit Roelof A. J., Smith Albert V., Sun Fangui, Taylor Kent D., Arnold Alice M., Barnes Michael R., Barratt Bryan J., Betteridge John, Boekholdt S. Matthijs, Boerwinkle Eric, Buckley Brendan M., Chen Y.-D. Ida, de Craen Anton J. M., Cummings Steven R., Denny Joshua C., Dubé Marie Pierre, Durrington Paul N., Eiriksdottir Gudny, Ford Ian, Guo Xiuqing, Harris Tamara B., Heckbert Susan R., Hofman Albert, Hovingh G. Kees, Kastelein John J. P., Launer Leonore J., Liu Ching-Ti, Liu Yongmei, Lumley Thomas, McKeigue Paul M., Munroe Patricia B., Neil Andrew, Nickerson Deborah A., Nyberg Fredrik, O'Brien Eoin, O'Donnell Christopher J., Post Wendy, Poulter Neil, Vasan Ramachandran S., Rice Kenneth, Rich Stephen S., Rivadeneira Fernando, Sattar Naveed, Sever Peter, Shaw-Hawkins Sue, Shields Denis C., Slagboom P. Eline, Smith Nicholas L., Smith Joshua D., Sotoodehnia Nona, Stanton Alice, Stott David J., Stricker Bruno H., Stürmer Til, Uitterlinden André G., Wei Wei-Qi, Westendorp Rudi G. J., Whitsel Eric A., Wiggins Kerri L., Wilke Russell A., Ballantyne Christie M., Colhoun Helen M., Cupples L. Adrienne, Franco Oscar H., Gudnason Vilmundur, Hitman Graham, Palmer Colin N. A., Psaty Bruce M., Ridker Paul M., Stafford Jeanette M., Stein Charles M., Tardif Jean-Claude, Caulfield Mark J., Jukema J. Wouter, Rotter Jerome I., Krauss Ronald M. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins Journal of medical genetics 2016;53 (12):835-845 [PubMed]
• Raal Frederick J., Braamskamp Marjet J., Selvey Sheryl L., Sensinger Charlotte H., Kastelein John J. Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia Journal of clinical lipidology 2016;10 (4):860-869 [PubMed]
• Vallejo-Vaz Antonio J., Akram Asif, Kondapally Seshasai Sreenivasa Rao, Cole Della, Watts Gerald F., Hovingh G. Kees, Kastelein John J. P., Mata Pedro, Raal Frederick J., Santos Raul D., Soran Handrean, Freiberger Tomas, Abifadel Marianne, Aguilar-Salinas Carlos A., Alnouri Fahad, Alonso Rodrigo, Al-Rasadi Khalid, Banach Maciej, Bogsrud Martin P., Bourbon Mafalda, Bruckert Eric, Car Josip, Ceska Richard, Corral Pablo, Descamps Olivier, Dieplinger Hans, Do Can T., Durst Ronen, Ezhov Marat V., Fras Zlatko, Gaita Dan, Gaspar Isabel M., Genest Jaques, Harada-Shiba Mariko, Jiang Lixin, Kayikcioglu Meral, Lam Carolyn S. P., Latkovskis Gustavs, Laufs Ulrich, Liberopoulos Evangelos, Lin Jie, Lin Nan, Maher Vincent, Majano Nelson, Marais A. David, März Winfried, Mirrakhimov Erkin, Miserez André R., Mitchenko Olena, Nawawi Hapizah, Nilsson Lennart, Nordestgaard Børge G., Paragh György, Petrulioniene Zaneta, Pojskic Belma, Reiner Željko, Sahebkar Amirhossein, Santos Lourdes E., Schunkert Heribert, Shehab Abdullah, Slimane M. Naceur, Stoll Mario, Su Ta-Chen, Susekov Andrey, Tilney Myra, Tomlinson Brian, Tselepis Alexandros D., Vohnout Branislav, Widén Elisabeth, Yamashita Shizuya, Catapano Alberico L., Ray Kausik K. Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration Atherosclerosis. Supplements 2016;22:1-32 [PubMed]
• Macpherson Merran, Hamrén Bengt, Braamskamp Marjet J. A. M., Kastelein John J. P., Lundström Torbjörn, Martin Paul D. Population pharmacokinetics of rosuvastatin in pediatric patients with heterozygous familial hypercholesterolemia European journal of clinical pharmacology 2016;72 (1):19-27 [PubMed]
• Zanoni Paolo, Khetarpal Sumeet A., Larach Daniel B., Hancock-Cerutti William F., Millar John S., Cuchel Marina, DerOhannessian Stephanie, Kontush Anatol, Surendran Praveen, Saleheen Danish, Trompet Stella, Jukema J. Wouter, de Craen Anton, Deloukas Panos, Sattar Naveed, Ford Ian, Packard Chris, Majumder Abdullah al Shafi, Alam Dewan S., Di Angelantonio Emanuele, Abecasis Goncalo, Chowdhury Rajiv, Erdmann Jeanette, Nordestgaard Børge G., Nielsen Sune F., Tybjærg-Hansen Anne, Schmidt Ruth Frikke, Kuulasmaa Kari, Liu Dajiang J., Perola Markus, Blankenberg Stefan, Salomaa Veikko, Männistö Satu, Amouyel Philippe, Arveiler Dominique, Ferrieres Jean, Müller-Nurasyid Martina, Ferrario Marco, Kee Frank, Willer Cristen J., Samani Nilesh, Schunkert Heribert, Butterworth Adam S., Howson Joanna M. M., Peloso Gina M., Stitziel Nathan O., Danesh John, Kathiresan Sekar, Kastelein John J. P., Hovingh G. Kees Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease Science 2016;351 (6278):1166-1171 [PubMed]
• Gibson C. Michael, Korjian Serge, Tricoci Pierluigi, Daaboul Yazan, Alexander John H., Steg Philippe G., Lincoff A. Michael, Kastelein John J. P., Mehran Roxana, D'Andrea Denise, Merkely Bela, Zarebinski Maciej, Ophius Ton Oude, Harrington Robert A. Rationale and design of Apo-I Event Reduction in Ischemic Syndromes I (AEGIS-I): A phase 2b, randomized, placebo-controlled, dose-ranging trial to investigate the safety and tolerability of CSL112, a reconstituted, infusible, human apoA-I, after acute myocardial infarction American heart journal 2016;180:22-28 [PubMed]
• Kastelein John J. P., Nissen Steven E., Rader Daniel J., Hovingh G. Kees, Wang Ming-Dauh, Shen Tong, Krueger Kathryn A. Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study European heart journal 2016;37 (17):1360-1369 [PubMed]
• Michael Gibson C., Korjian Serge, Tricoci Pierluigi, Daaboul Yazan, Yee Megan, Jain Purva, Alexander John H., Steg P. Gabriel, Lincoff A. Michael, Kastelein John J. P., Mehran Roxana, D'Andrea Denise M., Deckelbaum Lawrence I., Merkely Bela, Zarebinski Maciej, Ophuis Ton Oude, Harrington Robert A. Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I) Circulation 2016;134 (24):1918-1930 [PubMed]
• Patel Manesh R., Armstrong Paul W., Bhatt Deepak L., Braunwald Eugene, Camm A. John, Fox Keith A. A., Harrington Robert A., Hiatt William R., James Stefan K., Kirtane Ajay J., Leon Martin B., Lincoff A. Michael, Mahaffey Kenneth W., Mauri Laura, Mehran Roxana, Mehta Shamir R., Montalescot Gilles, Nicholls Stephen J., Perkovic Vlado, Peterson Eric D., Pocock Stuart J., Roe Matthew T., Sabatine Marc S., Sekeres Mikkael, Solomon Scott D., Steg Gabriel, Stone Gregg W., van de Werf Frans, Wallentin Lars, White Harvey D., Gibson Michael, Gibson C. Michael, Achaval-Giraud Alberto, Aguilar Salinas Carlos A., Alexander John H., Almeida Eduardo Dytz, Ambrosio Giuseppe, Ann Robin, Annichino-Bizzacchi Joyce M., Antman Elliott, Antonescu Adrian, Antorrena-Miranda Isabel, Apartsin Konstantin, Arce Migdalia, Arellano-Rodrigo Eduardo, Assadourian Assadour, Astrahanceva Anastasija, Badings Erik, Hovingh G. K., Kastelein John Sharing Data from Cardiovascular Clinical Trials - A Proposal New England journal of medicine 2016;375 (5):407-409 [PubMed]
• Braamskamp Marjet J. A. M., Kastelein John J. P., Kusters D. Meeike, Hutten Barbara A., Wiegman Albert Statin Initiation During Childhood in Patients With Familial Hypercholesterolemia: Consequences for Cardiovascular Risk Journal of the American College of Cardiology 2016;67 (4):455-456 [PubMed]
• Besseling Joost, Hovingh G. Kees, Huijgen Roeland, Kastelein John J. P., Hutten Barbara A. Statins in Familial Hypercholesterolemia: Consequences for Coronary Artery Disease and All-Cause Mortality Journal of the American College of Cardiology 2016;68 (3):252-260 [PubMed]
• Patel Aniruddh P., Peloso Gina M., Pirruccello James P., Johansen Christopher T., Dubé Joseph B., Larach Daniel B., Ban Matthew R., Dallinge-Thie Geesje M., Gupta Namrata, Boehnke Michael, Abecasis Gonçalo R., Kastelein John J. P., Hovingh G. Kees, Hegele Robert A., Rader Daniel J., Kathiresan Sekar Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution Atherosclerosis 2016;250:63-68 [PubMed]
• Besseling Joost The extended phenotype of familial hypercholesterolemia 2016. 283p. ISBN 9789462333888. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Hovingh G. K., Hutten B. A.)
• Sahebkar Amirhossein, Serban Corina, Ursoniu Sorin, Mikhailidis Dimitri P., Undas Anetta, Lip Gregory Y. H., Bittner Vera, Ray Kausik, Watts Gerald F., Hovingh G. Kees, Rysz Jacek, Kastelein John J. P., Banach Maciej The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials Thrombosis and haemostasis 2016;115 (3):520-532 [PubMed]
• Elbers L. P. B., Kastelein J. J. P., Sjouke B. Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges Current atherosclerosis reports 2016;18 (3):14 [PubMed]

2015

• Kastelein John J. P., Besseling Joost, Shah Sukrut, Bergeron Jean, Langslet Gisle, Hovingh G. Kees, Al-Saady Naab, Koeijvoets Michiel, Hunter John, Johnson-Levonas Amy O., Fable Jennifer, Sapre Aditi, Mitchel Yale Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study Lancet 2015;385 (9983):2153-2161 [PubMed]
• Gaudet Daniel, Alexander Veronica J., Baker Brenda F., Brisson Diane, Tremblay Karine, Singleton Walter, Geary Richard S., Hughes Steven G., Viney Nicholas J., Graham Mark J., Crooke Rosanne M., Witztum Joseph L., Brunzell John D., Kastelein John J. P. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia New England journal of medicine 2015;373 (5):438-447 [PubMed]
• Besseling Joost, Kastelein John J. P., Defesche Joep C., Hutten Barbara A., Hovingh G. Kees Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus JAMA 2015;313 (10):1029-1036 [PubMed]
• Sahebkar Amirhossein, Serban Corina, Mikhailidis Dimitri P., Undas Anetta, Lip Gregory Y. H., Muntner Paul, Bittner Vera, Ray Kausik K., Watts Gerald F., Hovingh G. Kees, Rysz Jacek, Kastelein John J. P., Banach Maciej Association between statin use and plasma D-dimer levels. A systematic review and meta-analysis of randomised controlled trials Thrombosis and haemostasis 2015;114 (3):546-557 [PubMed]
• Saleheen Danish, Scott Robert, Javad Sundas, Zhao Wei, Rodrigues Amrith, Picataggi Antonino, Lukmanova Daniya, Mucksavage Megan L., Luben Robert, Billheimer Jeffery, Kastelein John J. P., Boekholdt S. Matthijs, Khaw Kay-Tee, Wareham Nick, Rader Daniel J. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study Lancet. Diabetes and endocrinology 2015;3 (7):507-513 [PubMed]
• Serban Corina, Sahebkar Amirhossein, Ursoniu Sorin, Mikhailidis Dimitri P., Rizzo Manfredi, Lip Gregory Y. H., Kees Hovingh G., Kastelein John J. P., Kalinowski Leszek, Rysz Jacek, Banach Maciej A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations Scientific reports 2015;5:9902 [PubMed]
• Pers Tune H., Karjalainen Juha M., Chan Yingleong, Westra Harm-Jan, Wood Andrew R., Yang Jian, Lui Julian C., Vedantam Sailaja, Gustafsson Stefan, Esko Tonu, Frayling Tim, Speliotes Elizabeth K., Boehnke Michael, Raychaudhuri Soumya, Fehrmann Rudolf S. N., Hirschhorn Joel N., Franke Lude, Chu Audrey Y., Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L., Croteau-Chonka Damien C., Day Felix R., Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U., Karjalainen Juha, Lo Ken Sin, Locke Adam E., Mägi Reedik, Mihailov Evelin, Porcu Eleonora, Randall Joshua C., Scherag André, Vinkhuyzen Anna A. E., Winkler Thomas W., Workalemahu Tsegaselassie, Zhao Jing Hua, Absher Devin, Albrecht Eva, Anderson Denise, Baron Jeffrey, Beekman Marian, van der Velde Nathalie, Hovingh G. Kees, Kastelein John J. P. Biological interpretation of genome-wide association studies using predicted gene functions Nature communications 2015;6:5890 [PubMed]
• Hovingh G. Kees, Kastelein John J. P., van Deventer Sander J. H., Round Patrick, Ford John, Saleheen Danish, Rader Daniel J., Brewer H. Bryan, Barter Philip J. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial Lancet 2015;386 (9992):452-460 [PubMed]
• Marx Nikolaus, Rosenstock Julio, Kahn Steven E., Zinman Bernard, Kastelein John J., Lachin John M., Espeland Mark A., Bluhmki Erich, Mattheus Michaela, Ryckaert Bart, Patel Sanjay, Johansen Odd Erik, Woerle Hans-Juergen Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA (R)) Diabetes & vascular disease research 2015;12 (3):164-174 [PubMed]
• Kootte Ruud S., Smits Loek P., van der Valk Fleur M., Dasseux Jean-Louis, Keyserling Constance H., Barbaras Ronald, Paolini John F., Santos Raul D., van Dijk Theo H., Dallinga-van Thie Geesje M., Nederveen Aart J., Mulder Willem J. M., Hovingh G. Kees, Kastelein John J. P., Groen Albert K., Stroes Erik S. Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA Journal of lipid research 2015;56 (3):703-712 [PubMed]
• Puri Rishi, Nissen Steven E., Menon Venu, Shao Mingyuan, Hsu Amy, Bakris George L., Kastelein John J. P., Williams Bryan, Armbrecht Juergen, Brunel Patrick, Kataoka Yu, Nicholls Stephen J. Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS Atherosclerosis 2015;243 (2):553-559 [PubMed]
• Ballantyne Christie M., Braeckman Rene A., Bays Harold E., Kastelein John J., Otvos James D., Stirtan William G., Doyle Ralph T., Soni Paresh N., Juliano Rebecca A. Effects of icosapent ethyl on lipoprotein particle concentration and size in statin-treated patients with persistent high triglycerides (the ANCHOR Study) Journal of clinical lipidology 2015;9 (3):377-383 [PubMed]
• Robinson Jennifer G., Farnier Michel, Krempf Michel, Bergeron Jean, Luc Gérald, Averna Maurizio, Stroes Erik S., Langslet Gisle, Raal Frederick J., El Shahawy Mahfouz, Koren Michael J., Lepor Norman E., Lorenzato Christelle, Pordy Robert, Chaudhari Umesh, Kastelein John J. P., Caccavo Alberto, Codutti Oscar, Gelersztein Elisabeth, Vico Marisa, Zaidman Cesar, Majul Claudio, Balthazar Yohan, Capiau Luc, Vrolix Mathias, Vermeersch Paul, Gotchev Dobromir, Todorov Georgi, Tumbev Haralin, Tzekova Maria, Gronkova Naydenka, Dimov Bojidar, Nikolaeva Antonoaneta, Devedzhiev Tsvetan, Mincheva Valentina, D'Ignazio Giuseppe, Dzongowski Peter, Elliott Thomas, Hart Randy, Hoag Gordon, Martinho Valdemar, O'Mahony Michael, Tellier Guy, Pandey Shekhar, Heaton Kenneth, Constance Christian, Phaneuf Denis-Carl, Shu Daniel, Narvaez Nancy Cardenas, Cañon Claudia Olivares Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events New England journal of medicine 2015;372 (16):1489-1499 [PubMed]
• Moriarty Patrick M., Thompson Paul D., Cannon Christopher P., Guyton John R., Bergeron Jean, Zieve Franklin J., Bruckert Eric, Jacobson Terry A., Kopecky Stephen L., Baccara-Dinet Marie T., Du Yunling, Pordy Robert, Gipe Daniel A., Drexel Heinz, Kaser Susanne, Toplak Hermann, Baass Alexis, Gaudet Daniel, Farnier Michel, Krempf Michel, Moulin Philippe, Serusclat Pierre, Cohen Hofit, Gavish Dov, Hussein Osama, Maislos Maximo, Schurr Daniel, Arca Marcello, Averna Maurizio, Pozzi Claudio, Balsamo Cinisello, Heggen Eli, Langslet Gisle, Al-Bahrani Ali, Blagden Mark, O'Kane Maurice, Reynolds Tim, Viljoen Adie, Andersen James, Awasty Vivek, Bayron Carlos, Bestermann William, Bolster Eric, deGoma Emil, Dunn Fredrick, Duprez Daniel, Elam Marshall, El Shahawy Mahfouz, Faillace Robert, Kastelein John J. P. Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial Journal of clinical lipidology 2015;9 (6):758-769 [PubMed]
• Kusters D. Meeike, Caceres Maria, Coll Mauricio, Cuffie Cynthia, Gagné Claude, Jacobson Marc S., Kwiterovich Peter O., Lee Raymond, Lowe Robert S., Massaad Rachid, McCrindle Brian W., Musliner Thomas A., Triscari Joseph, Kastelein John J. P. Efficacy and safety of ezetimibe monotherapy in children with heterozygous familial or nonfamilial hypercholesterolemia Journal of pediatrics 2015;166 (6):1377-84.e1-3 [PubMed]
• Braamskamp Marjet J. A. M., Stefanutti Claudia, Langslet Gisle, Drogari Euridiki, Wiegman Albert, Hounslow Neil, Kastelein John J. P., Kolovou Genovefa, Elisaf Moses, Middeldorp Saskia, García Jiménez Ma Concepción, Ponce Esperanza Castejón, Di Giacomo Serafina, Morozzi Claudia, Pozzi Claudia, Peretti Noel, Thompson Gilbert, McCrindle Brian, Guardamagna Ornella Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk Journal of pediatrics 2015;167 (2):338-+ [PubMed]
• Braamskamp Marjet J. A. M., Langslet Gisle, McCrindle Brian W., Cassiman David, Francis Gordon A., Gagné Claude, Gaudet Daniel, Morrison Katherine M., Wiegman Albert, Turner Traci, Kusters D. Meeike, Miller Elinor, Raichlen Joel S., Wissmar Jenny, Martin Paul D., Stein Evan A., Kastelein John J. P. Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study Journal of clinical lipidology 2015;9 (6):741-750 [PubMed]
• Do Ron, Stitziel Nathan O., Won Hong-Hee, Jørgensen Anders Berg, Duga Stefano, Angelica Merlini Pier, Kiezun Adam, Farrall Martin, Goel Anuj, Zuk Or, Guella Illaria, Asselta Rosanna, Lange Leslie A., Peloso Gina M., Auer Paul L., Girelli Domenico, Martinelli Nicola, Farlow Deborah N., DePristo Mark A., Roberts Robert, Stewart Alexander F. R., Saleheen Danish, Danesh John, Epstein Stephen E., Sivapalaratnam Suthesh, Hovingh G. Kees, Kastelein John J., Samani Nilesh J., Schunkert Heribert, Erdmann Jeanette, Shah Svati H., Kraus William E., Davies Robert, Nikpay Majid, Johansen Christopher T., Wang Jian, Hegele Robert A., Hechter Eliana, Marz Winfried, Kleber Marcus E., Huang Jie, Johnson Andrew D., Li Mingyao, Burke Greg L., Gross Myron, Liu Yongmei, Assimes Themistocles L., Heiss Gerardo, Lange Ethan M., Folsom Aaron R. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction Nature 2015;518 (7537):102-+ [PubMed]
• Stitziel Nathan O., Peloso Gina M., Abifadel Marianne, Cefalu Angelo B., Fouchier Sigrid, Motazacker M. Mahdi, Tada Hayato, Larach Daniel B., Awan Zuhier, Haller Jorge F., Pullinger Clive R., Varret Mathilde, Rabès Jean-Pierre, Noto Davide, Tarugi Patrizia, Kawashiri Masa-Aki, Nohara Atsushi, Yamagishi Masakazu, Risman Marjorie, deo Rahul, Ruel Isabelle, Shendure Jay, Nickerson Deborah A., Wilson James G., Rich Stephen S., Gupta Namrata, Farlow Deborah N., Neale Benjamin M., Daly Mark J., Kane John P., Freeman Mason W., Genest Jacques, Rader Daniel J., Mabuchi Hiroshi, Kastelein John J. P., Hovingh G. Kees, Averna Maurizio R., Gabriel Stacey, Boileau Catherine, Kathiresan Sekar Exome sequencing in suspected monogenic dyslipidemias Circulation. Cardiovascular genetics 2015;8 (2):343-350 [PubMed]
• Mooij Hans L., Bernelot Moens Sophie J., Gordts Philip L. S. M., Stanford Kristin I., Foley Erin M., van den Boogert Marjolein A. W., Witjes Julia J., Hassing H. Carlijne, Tanck Michael W., van de Sande Michiel A. J., Levels J. Han, Kastelein John J. P., Stroes Erik S. G., Dallinga-Thie Geesje M., Esko Jeff D., Nieuwdorp Max Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans Journal of lipid research 2015;56 (3):665-673 [PubMed]
• Vallejo-Vaz Antonio J., Kondapally Seshasai Sreenivasa Rao, Cole Della, Hovingh G. Kees, Kastelein John J. P., Mata Pedro, Raal Frederick J., Santos Raul D., Soran Handrean, Watts Gerald F., Abifadel Marianne, Aguilar-Salinas Carlos A., Akram Asif, Alnouri Fahad, Alonso Rodrigo, Al-Rasadi Khalid, Banach Maciej, Bogsrud Martin P., Bourbon Mafalda, Bruckert Eric, Car Josip, Corral Pablo, Descamps Olivier, Dieplinger Hans, Durst Ronen, Freiberger Tomas, Gaspar Isabel M., Genest Jaques, Harada-Shiba Mariko, Jiang Lixin, Kayikcioglu Meral, Lam Carolyn S. P., Latkovskis Gustavs, Laufs Ulrich, Liberopoulos Evangelos, Nilsson Lennart, Nordestgaard Børge G., O'Donoghue John M., Sahebkar Amirhossein, Schunkert Heribert, Shehab Abdulla, Stoll Mario, Su Ta-Chen, Susekov Andrey, Widén Elisabeth, Catapano Alberico L., Ray Kausik K. Familial hypercholesterolaemia: A global call to arms Atherosclerosis 2015;243 (1):257-259 [PubMed]
• Locke Adam E., Kahali Bratati, Berndt Sonja I., Justice Anne E., Pers Tune H., Day Felix R., Powell Corey, Vedantam Sailaja, Buchkovich Martin L., Yang Jian, Croteau-Chonka Damien C., Esko Tonu, Fall Tove, Ferreira Teresa, Gustafsson Stefan, Kutalik Zoltán, Luan Jian'an, Mägi Reedik, Randall Joshua C., Winkler Thomas W., Wood Andrew R., Workalemahu Tsegaselassie, Faul Jessica D., Smith Jennifer A., Hua Zhao Jing, Zhao Wei, Chen Jin, Fehrmann Rudolf, Hedman Åsa K., Karjalainen Juha, Schmidt Ellen M., Absher Devin, Amin Najaf, Anderson Denise, Beekman Marian, Bolton Jennifer L., Bragg-Gresham Jennifer L., Buyske Steven, Demirkan Ayse, Deng Guohong, Ehret Georg B., Feenstra Bjarke, Feitosa Mary F., Fischer Krista, Goel Anuj, Gong Jian, Jackson Anne U., Hovingh G. Kees, Kastelein John J. P., Chen Wei Genetic studies of body mass index yield new insights for obesity biology Nature 2015;518 (7538):197-U401 [PubMed]
• Braamskamp Marjet J. A. M., Kusters D. Meeike, Wiegman Albert, Avis Hans J., Wijburg Frits A., Kastelein John J. P., van Trotsenburg A. S. Paul, Hutten Barbara A. Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood Atherosclerosis 2015;241 (2):427-432 [PubMed]
• Sjouke Barbara, Kusters D. Meeike, Kindt Iris, Besseling Joost, Defesche Joep C., Sijbrands Eric J. G., Roeters van Lennep Jeanine E., Stalenhoef Anton F. H., Wiegman Albert, de Graaf Jacqueline, Fouchier Sigrid W., Kastelein John J. P., Hovingh G. Kees Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome European heart journal 2015;36 (9):560-565 [PubMed]
• Sjouke Barbara, Hovingh G. Kees, Kastelein John J. P., Stefanutti Claudia Homozygous autosomal dominant hypercholesterolaemia: prevalence, diagnosis, and current and future treatment perspectives Current opinion in lipidology 2015;26 (3):200-209 [PubMed]
• Versmissen Jorie, Oosterveer Daniëlla M., Yazdanpanah Mojgan, Dehghan Abbas, Hólm Hilma, Erdman Jeanette, Aulchenko Yurii S., Thorleifsson Gudmar, Schunkert Heribert, Huijgen Roeland, Vongpromek Ranitha, Uitterlinden André G., Defesche Joep C., van Duijn Cornelia M., Mulder Monique, Dadd Tony, Karlsson Hróbjartur D., Ordovas Jose, Kindt Iris, Jarman Amelia, Hofman Albert, van Vark-van der Zee Leonie, Blommesteijn-Touw Adriana C., Kwekkeboom Jaap, Liem Anho H., van der Ouderaa Frans J., Calandra Sebastiano, Bertolini Stefano, Averna Maurizio, Langslet Gisle, Ose Leiv, Ros Emilio, Almagro Fátima, de Leeuw Peter W., Civeira Fernando, Masana Luis, Pintó Xavier, Simoons Maarten L., Schinkel Arend F. L., Green Martin R., Zwinderman Aeilko H., Johnson Keith J., Schaefer Arne, Neil Andrew, Witteman Jacqueline C. M., Humphries Steve E., Kastelein John J. P., Sijbrands Eric J. G. Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach European journal of human genetics 2015;23 (3):381-387 [PubMed]
• Banach Maciej, Serban Corina, Sahebkar Amirhossein, Mikhailidis Dimitri P., Ursoniu Sorin, Ray Kausik K., Rysz Jacek, Toth Peter P., Muntner Paul, Mosteoru Svetlana, García-García Hector M., Hovingh G. Kees, Kastelein John J. P., Serruys Patrick W. Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies BMC medicine 2015;13 (1):229 [PubMed]
• van Wijk Diederik F., Strang Aart C., Duivenvoorden Raphael, Enklaar Dirk-Jan F., Zwinderman Aeilko H., van der Geest Rob J., Kastelein John J. P., de Groot Eric, Stroes Erik S. G., Nederveen Aart J. Increasing the Spatial Resolution of 3T Carotid MRI Has No Beneficial Effect for Plaque Component Measurement Reproducibility PLoS ONE 2015;10 (7):e0130878 [PubMed]
• Watts Gerald F., Gidding Samuel, Wierzbicki Anthony S., Toth Peter P., Alonso Rodrigo, Brown W. Virgil, Bruckert Eric, Defesche Joep, Lin Khoo Kah, Livingston Michael, Mata Pedro, Parhofer Klaus G., Raal Frederick J., Santos Raul D., Sijbrands Eric J. G., Simpson William G., Sullivan David R., Susekov Andrey V., Tomlinson Brian, Wiegman Albert, Yamashita Shizuya, Kastelein John J. P. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation European journal of preventive cardiology 2015;22 (7):849-854 [PubMed]
• Barter Philip J., Nicholls Stephen J., Kastelein John J. P., Rye Kerry-Anne Is Cholesteryl Ester Transfer Protein Inhibition an Effective Strategy to Reduce Cardiovascular Risk? CETP Inhibition as a Strategy to Reduce Cardiovascular Risk: The Pro Case Circulation 2015;132 (5):423-432 [PubMed]
• Ljunggren Stefan A., Levels Johannes H. M., Hovingh Kees, Holleboom Adriaan G., Vergeer Menno, Argyri Letta, Gkolfinopoulou Christina, Chroni Angeliki, Sierts Jeroen A., Kastelein John J., Kuivenhoven Jan Albert, Lindahl Mats, Karlsson Helen Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2015;1851 (12):1587-1595 [PubMed]
• Braamskamp Marjet J. A. M., Kusters D. Meeike, Avis Hans J., Smets Ellen M. A., Wijburg Frits A., Kastelein John J. P., Wiegman Albert, Hutten Barbara A. Long-term statin treatment in children with familial hypercholesterolemia: more insight into tolerability and adherence Paediatric drugs 2015;17 (2):159-166 [PubMed]
• Braamskamp Marjet Management of pediatric familial hypercholesterolemia; growing older, getting wiser 2015. 237p. ISBN 9789462331501. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Wijburg F. A.; Co-supervisors: Hutten B. A., Wiegman A.)
• Shungin Dmitry, Winkler Thomas W., Croteau-Chonka Damien C., Ferreira Teresa, Locke Adam E., Mägi Reedik, Strawbridge Rona J., Pers Tune H., Fischer Krista, Justice Anne E., Workalemahu Tsegaselassie, Wu Joseph M. W., Buchkovich Martin L., Heard-Costa Nancy L., Roman Tamara S., Drong Alexander W., Song Ci, Gustafsson Stefan, Day Felix R., Esko Tonu, Fall Tove, Kutalik Zoltán, Luan Jian'an, Randall Joshua C., Scherag André, Vedantam Sailaja, Wood Andrew R., Chen Jin, Fehrmann Rudolf, Karjalainen Juha, Kahali Bratati, Liu Ching-Ti, Schmidt Ellen M., Absher Devin, Amin Najaf, Anderson Denise, Beekman Marian, Bragg-Gresham Jennifer L., Buyske Steven, Demirkan Ayse, Ehret Georg B., Feitosa Mary F., Goel Anuj, Jackson Anne U., Johnson Toby, Kleber Marcus E., Henneman Peter, Hovingh G. Kees, Kastelein John J. P., Chen Wei New genetic loci link adipose and insulin biology to body fat distribution Nature 2015;518 (7538):187-U378 [PubMed]
• Kastelein John J. P., Ginsberg Henry N., Langslet Gisle, Hovingh G. Kees, Ceska Richard, Dufour Robert, Blom Dirk, Civeira Fernando, Krempf Michel, Lorenzato Christelle, Zhao Jian, Pordy Robert, Baccara-Dinet Marie T., Gipe Daniel A., Geiger Mary Jane, Farnier Michel ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia European heart journal 2015;36 (43):2996-3003 [PubMed]
• Stoekenbroek Robert M., Kastelein John J. P., Huijgen Roeland PCSK9 inhibition: the way forward in the treatment of dyslipidemia BMC medicine 2015;13 (1):258 [PubMed]
• Robinson Jennifer G., Kastelein John J. P. PCSK9 Inhibitors and Cardiovascular Events Reply New England journal of medicine 2015;373 (8):774 [PubMed]
• de Backer Guy, Besseling Joost, Chapman John, Hovingh G. Kees, Kastelein John J. P., Kotseva Kornelia, Ray Kausik, Reiner Željko, Wood David, de Bacquer Dirk Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology Atherosclerosis 2015;241 (1):169-175 [PubMed]
• Maiwald Stephanie Rare genetic variants associated with early onset CVD 2015. 208p. ISBN 9789462037502. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Ouwehand W. H.; Co-supervisors: Trip M. D., Dallinga-Thie G., Hovingh G. K.)
• Boekholdt S. Matthijs, Hovingh G. Kees, Waters David D., Grundy Scott M., Kastelein John J. P. Reply: statin-induced low low-density lipoprotein cholesterol level: is lower better? Journal of the American College of Cardiology 2015;65 (1):109 [PubMed]
• Kohli Payal, Waters David D., Nemr Rita, Arsenault Benoit J., Messig Michael, Demicco David A., Laskey Rachel, Kastelein John J. P. Risk of New-Onset Diabetes and Cardiovascular Risk Reduction From High-Dose Statin Therapy in Pre-Diabetics and Non-Pre-Diabetics Journal of the American College of Cardiology 2015;65 (4):402-404 [PubMed]
• Besseling Joost, Sjouke Barbara, Kastelein John J. P. Screening and treatment of familial hypercholesterolemia - Lessons from the past and opportunities for the future (based on the Anitschkow Lecture 2014) Atherosclerosis 2015;241 (2):597-606 [PubMed]
• Hovingh G. Kees, Smits Loek P., Stefanutti Claudia, Soran Handrean, Kwok See, de Graaf Jacqueline, Gaudet Daniel, Keyserling Constance H., Klepp Heather, Frick Jennifer, Paolini John F., Dasseux Jean-Louis, Kastelein John J. P., Stroes Erik S. The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study American heart journal 2015;169 (5):736-742.e1 [PubMed]
• de Backer G., Kastelein J. J. P., Landmesser U. The year in cardiology 2014: prevention European heart journal 2015;36 (4):214-218 [PubMed]
• Arsenault Benoit J., Boyer Marjorie, Kastelein John J. P. What does the future hold for cholesteryl ester transfer protein inhibition? Current opinion in lipidology 2015;26 (6):526-535 [PubMed]

2014

• Kusters Dorothé M., Wiegman A., Kastelein John J. P., Hutten Barbara A. Carotid Intima-Media Thickness in Children With Familial Hypercholesterolemia Circulation research 2014;114 (2):307-310 [PubMed]
• Flaim Joann D., Grundy John S., Baker Brenda F., McGowan Mary P., Kastelein John J. P. Changes in mipomersen dosing regimen provide similar exposure with improved tolerability in randomized placebo-controlled study of healthy volunteers Journal of the American Heart Association 2014;3 (2):e000560 [PubMed]
• van Iperen Erik P. A., Sivapalaratnam Suthesh, Boekholdt S. Matthijs, Hovingh G. Kees, Maiwald Stephanie, Tanck Michael W., Soranzo Nicole, Stephens Jonathan C., Sambrook Jennifer G., Levi Marcel, Ouwehand Willem H., Kastelein John Jp, Trip Mieke D., Zwinderman Aeilko H. Common genetic variants do not associate with CAD in familial hypercholesterolemia European journal of human genetics 2014;22 (6):809-813 [PubMed]
• Kastelein John J. P. Decade in review--dyslipidaemia: Resurgence of targets and compounds to treat dyslipidaemia Nature reviews. Cardiology 2014;11 (11):629-631 [PubMed]
• Wood Andrew R., Esko Tonu, Yang Jian, Vedantam Sailaja, Pers Tune H., Gustafsson Stefan, Chu Audrey Y., Estrada Karol, Luan Jian'an, Kutalik Zoltán, Amin Najaf, Buchkovich Martin L., Croteau-Chonka Damien C., Day Felix R., Duan Yanan, Fall Tove, Fehrmann Rudolf, Ferreira Teresa, Jackson Anne U., Karjalainen Juha, Lo Ken Sin, Locke Adam E., Mägi Reedik, Mihailov Evelin, Porcu Eleonora, Randall Joshua C., Scherag André, Vinkhuyzen Anna A. E., Westra Harm-Jan, Winkler Thomas W., Workalemahu Tsegaselassie, Zhao Jing Hua, Absher Devin, Albrecht Eva, Anderson Denise, Baron Jeffrey, Beekman Marian, Demirkan Ayse, Ehret Georg B., Feenstra Bjarke, Feitosa Mary F., Fischer Krista, Fraser Ross M., Goel Anuj, Gong Jian, Justice Anne E., Kanoni Stavroula, van der Velde Nathalie, Hovingh G. Kees, Kastelein John J. P. Defining the role of common variation in the genomic and biological architecture of adult human height Nature genetics 2014;46 (11):1173-1186 [PubMed]
• Kastelein John J. P. Dyslipidaemia in perspective Lancet 2014;384 (9943):566-568 [PubMed]
• Tardif Jean-Claude, Ballantyne Christie M., Barter Philip, Dasseux Jean-Louis, Fayad Zahi A., Guertin Marie-Claude, Kastelein John J. P., Keyserling Constance, Klepp Heather, Koenig Wolfgang, L'allier Philippe L., Lespérance Jacques, Lüscher Thomas F., Paolini John F., Tawakol Ahmed, Waters David D., Pfeffer M., Brown V., Rouleau J., Watkins P., Wei L. J., Gosselin G., Chayer C., Lanthier S., Pelletier G. B., Racine N., Agarwal H., Brilakis E., Cannon L., Carrié D., Corbelli J., Coste P., de Winter R., Diaz A., Eisenberg S., Ennis B., Fajadet J., Fam N., Fortuin D., Gessler C., Grines C., Guerra D., Gum H., Haldis T., Heestermans T., Herrman J. P., Huynh T., Kedhi E., Koren M., Kouz S. Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial European heart journal 2014;35 (46):3277-3286 [PubMed]
• Kastelein John J. P., Robinson Jennifer G., Farnier Michel, Krempf Michel, Langslet Gisle, Lorenzato Christelle, Gipe Daniel A., Baccara-Dinet Marie T. Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2014;28 (3):281-289 [PubMed]
• Sjouke Barbara, Langslet Gisle, Ceska Richard, Nicholls Stephen J., Nissen Steven E., Öhlander Maria, Ladenson Paul W., Olsson Anders G., Hovingh G. Kees, Kastelein John J. P. Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study Lancet. Diabetes and endocrinology 2014;2 (6):455-463 [PubMed]
• Tragante Vinicius, Barnes Michael R., Ganesh Santhi K., Lanktree Matthew B., Guo Wei, Franceschini Nora, Smith Erin N., Johnson Toby, Holmes Michael V., Padmanabhan Sandosh, Karczewski Konrad J., Almoguera Berta, Barnard John, Baumert Jens, Chang Yen-Pei Christy, Elbers Clara C., Farrall Martin, Fischer Mary E., Gaunt Tom R., Gho Johannes M. I. H., Gieger Christian, Goel Anuj, Gong Yan, Isaacs Aaron, Kleber Marcus E., Mateo Leach Irene, McDonough Caitrin W., Meijs Matthijs F. L., Melander Olle, Nelson Christopher P., Nolte Ilja M., Pankratz Nathan, Price Tom S., Shaffer Jonathan, Shah Sonia, Tomaszewski Maciej, van der Most Peter J., van Iperen Erik P. A., Vonk Judith M., Witkowska Kate, Wong Caroline O. L., Zhang Li, Beitelshees Amber L., Berenson Gerald S., Bhatt Deepak L., Brown Morris, Burt Amber, Cooper-DeHoff Rhonda M., Connell John M., Cruickshanks Karen J., Curtis Sean P., Davey-Smith George, Delles Christian, Gansevoort Ron T., Guo Xiuqing, Haiqing Shen, Hastie Claire E., Hofker Marten H., Hovingh G. Kees, Kim Daniel S., Kirkland Susan A., Klein Barbara E., Klein Ronald, Li Yun R., Maiwald Steffi, Newton-Cheh Christopher, O'Brien Eoin T., Onland-Moret N. Charlotte, Palmas Walter, Parsa Afshin, Penninx Brenda W., Pettinger Mary, Vasan Ramachandran S., Ranchalis Jane E., M Ridker Paul, Rose Lynda M., Sever Peter, Shimbo Daichi, Steele Laura, Stolk Ronald P., Thorand Barbara, Trip Mieke D., van Duijn Cornelia M., Verschuren W. Monique, Wijmenga Cisca, Wyatt Sharon, Young J. Hunter, Zwinderman Aeilko H., Bezzina Connie R., Boerwinkle Eric, Casas Juan P., Caulfield Mark J., Chakravarti Aravinda, Chasman Daniel I., Davidson Karina W., Doevendans Pieter A., Dominiczak Anna F., FitzGerald Garret A., Gums John G., Fornage Myriam, Hakonarson Hakon, Halder Indrani, Hillege Hans L., Illig Thomas, Jarvik Gail P., Johnson Julie A., Kastelein John J. P., Koenig Wolfgang, Kumari Meena, März Winfried, Murray Sarah S., O'Connell Jeffery R., Oldehinkel Albertine J., Pankow James S., Rader Daniel J., Redline Susan, Reilly Muredach P., Schadt Eric E., Kottke-Marchant Kandice, Snieder Harold, Snyder Michael, Stanton Alice V., Tobin Martin D., Uitterlinden André G., van der Harst Pim, van der Schouw Yvonne T., Samani Nilesh J., Watkins Hugh, Johnson Andrew D., Reiner Alex P., Zhu Xiaofeng, de Bakker Paul I. W., Levy Daniel, Asselbergs Folkert W., Munroe Patricia B., Keating Brendan J. Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci American journal of human genetics 2014;94 (3):349-360 [PubMed]
• Singaraja Roshni R., Tietjen Ian, Hovingh G. Kees, Franchini Patrick L., Radomski Chris, Wong Kenny, vanHeek Margaret, Stylianou Ioannis M., Lin Linus, Wang Liangsu, Mitnaul Lyndon, Hubbard Brian, Winther Michael, Mattice Maryanne, Legendre Annick, Sherrington Robin, Kastelein John J., Akinsanya Karen, Plump Andrew, Hayden Michael R. Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans Journal of lipid research 2014;55 (8):1693-1701 [PubMed]
• van Wijk Diederik F., Strang Aart C., Duivenvoorden Raphael, Enklaar Dirk-Jan F., van der Geest Rob J., Kastelein John J. P., de Groot Eric, Stroes Erik S. G., Nederveen Aart J. Increasing spatial resolution of 3T MRI scanning improves reproducibility of carotid arterial wall dimension measurements Magma (New York, N.Y.) 2014;27 (3):219-226 [PubMed]
• Watts Gerald F., Gidding Samuel, Wierzbicki Anthony S., Toth Peter P., Alonso Rodrigo, Brown W. Virgil, Bruckert Eric, Defesche Joep, Lin Khoo Kah, Livingston Michael, Mata Pedro, Parhofer Klaus G., Raal Frederick J., Santos Raul D., Sijbrands Eric J. G., Simpson William G., Sullivan David R., Susekov Andrey V., Tomlinson Brian, Wiegman Albert, Yamashita Shizuya, Kastelein John J. P. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation International journal of cardiology 2014;171 (3):309-325 [PubMed]
• Watts Gerald F., Gidding Samuel, Wierzbicki Anthony S., Toth Peter P., Alonso Rodrigo, Brown W. Virgil, Bruckert Eric, Defesche Joep, Lin Khoo Kah, Livingston Michael, Mata Pedro, Parhofer Klaus G., Raal Frederick J., Santos Raul D., Sijbrands Eric J. G., Simpson William G., Sullivan David R., Susekov Andrey V., Tomlinson Brian, Wiegman Albert, Yamashita Shizuya, Kastelein John J. P. Integrated Guidance on the Care of Familial Hypercholesterolaemia from the International FH Foundation: Executive Summary Journal of atherosclerosis and thrombosis 2014;21 (4):368-374 [PubMed]
• Watts Gerald F., Gidding Samuel, Wierzbicki Anthony S., Toth Peter P., Alonso Rodrigo, Brown W. Virgil, Bruckert Eric, Defesche Joep, Lin Khoo Kah, Livingston Michael, Mata Pedro, Parhofer Klaus G., Raal Frederick J., Santos Raul D., Sijbrands Eric J. G., Simpson William G., Sullivan David R., Susekov Andrey V., Tomlinson Brian, Wiegman Albert, Yamashita Shizuya, Kastelein John J. P. Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation Journal of clinical lipidology 2014;8 (2):148-172 [PubMed]
• Rader Daniel J., Kastelein John J. P. Lomitapide and Mipomersen Two First-in-Class Drugs for Reducing Low-Density Lipoprotein Cholesterol in Patients With Homozygous Familial Hypercholesterolemia Circulation 2014;129 (9):1022-1032 [PubMed]
• Mooij H. L., Cabrales P., Bernelot Moens S. J., Xu D., Udayappan S. D., Tsai A. G., van der Sande M. A. J., de Groot E., Intaglietta M., Kastelein J. J. P., Dallinga-Thie G. M., Esko J. D., Stroes E. S., Nieuwdorp M. Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function Journal of the American Heart Association 2014;3 (6):e001274 [PubMed]
• Braamskamp Marjet J. A. M., Hutten Barbara A., Wiegman Albert, Kastelein John J. P. Management of hypercholesterolemia in children Paediatric drugs 2014;16 (2):105-114 [PubMed]
• Roth Eli M., Taskinen Marja-Riitta, Ginsberg Henry N., Kastelein John J. P., Colhoun Helen M., Robinson Jennifer G., Merlet Laurence, Pordy Robert, Baccara-Dinet Marie T. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized Phase 3 trial International journal of cardiology 2014;176 (1):55-61 [PubMed]
• Maiwald Stephanie, Sivapalaratnam Suthesh, Motazacker Mahdi M., van Capelleveen Julian C., Bot Ilze, de Jager Saskia C., van Eck Miranda, Jolley Jennifer, Kuiper Johan, Stephens Jonathon, Albers Cornelius A., Vosmeer C. Ruben, Kruize Heleen, Geerke Daan P., van der Wal Allard C., van der Loos Chris M., Kastelein John J. P., Trip Mieke D., Ouwehand Willem H., Dallinga-Thie Geesje M., Hovingh G. Kees Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis PLoS ONE 2014;9 (5):e98289 [PubMed]
• Fouchier Sigrid W., Dallinga-Thie Geesje M., Meijers Joost C. M., Zelcer Noam, Kastelein John J. P., Defesche Joep C., Hovingh G. Kees Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia Circulation research 2014;115 (6):552-555 [PubMed]
• van Wijk Diederik F., Sjouke Barbara, Figueroa Amparo, Emami Hamed, van der Valk Fleur M., MacNabb Megan H., Hemphill Linda C., Schulte Dominik M., Koopman Marion G., Lobatto Mark E., Verberne Hein J., Fayad Zahi A., Kastelein John J. P., Mulder Willem J. M., Hovingh G. Kees, Tawakol Ahmed, Stroes Erik S. G. Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia Journal of the American College of Cardiology 2014;64 (14):1418-1426 [PubMed]
• van Capelleveen Julian C., Brewer H. Bryan, Kastelein John J. P., Hovingh G. Kees Novel Therapies Focused on the High-Density Lipoprotein Particle Circulation research 2014;114 (1):193-204 [PubMed]
• Kastelein John J. P., Maki Kevin C., Susekov Andrey, Ezhov Marat, Nordestgaard Borge G., Machielse Ben N., Kling Douglas, Davidson Michael H. Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial Journal of clinical lipidology 2014;8 (1):94-106 [PubMed]
• Postmus Iris, Trompet Stella, Deshmukh Harshal A., Barnes Michael R., Li Xiaohui, Warren Helen R., Chasman Daniel I., Zhou Kaixin, Arsenault Benoit J., Donnelly Louise A., Wiggins Kerri L., Avery Christy L., Griffin Paula, Feng QiPing, Taylor Kent D., Li Guo, Evans Daniel S., Smith Albert V., de Keyser Catherine E., Johnson Andrew D., de Craen Anton J. M., Stott David J., Buckley Brendan M., Ford Ian, Westendorp Rudi G. J., Slagboom P. Eline, Sattar Naveed, Munroe Patricia B., Sever Peter, Poulter Neil, Stanton Alice, Shields Denis C., O'Brien Eoin, Shaw-Hawkins Sue, Chen Y.-D. Ida, Nickerson Deborah A., Smith Joshua D., Dubé Marie Pierre, Boekholdt S. Matthijs, Hovingh G. Kees, Kastelein John J. P., McKeigue Paul M., Betteridge John, Neil Andrew, Durrington Paul N., Doney Alex, Carr Fiona, Morris Andrew, McCarthy Mark I., Groop Leif Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins Nature communications 2014;5:5068 [PubMed]
• Arsenault Benoit J., Barter Philip, Demicco David A., Bao Weihang, Preston Gregory M., LaRosa John C., Grundy Scott M., Deedwania Prakash, Greten Heiner, Wenger Nanette K., Shepherd James, Waters David D., Kastelein John J. P. Prediction of cardiovascular events in statin-treated stable coronary patients of the treating to new targets randomized controlled trial by lipid and non-lipid biomarkers PLoS ONE 2014;9 (12):e114519 [PubMed]
• Koopal Charlotte, Visseren Frank L. J., Kastelein John J. P., Westerink Jan Premature atherosclerosis, extremely low HDL-cholesterol and concurrent defects in APOA1 and ABCA1 genes: a family case report International journal of cardiology 2014;177 (1):e19-e21 [PubMed]
• Besseling Joost, Kindt Iris, Hof Michel, Kastelein John J. P., Hutten Barbara A., Hovingh G. Kees Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers Atherosclerosis 2014;233 (1):219-223 [PubMed]
• Kusters D. Meeike, Avis Hans J., de Groot Eric, Wijburg Frits A., Kastelein John J. P., Wiegman Albert, Hutten Barbara A. Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia JAMA 2014;312 (10):1055-1057 [PubMed]
• Ray Kausik K., Kastelein John J. P., Boekholdt S. Matthijs, Nicholls Stephen J., Khaw Kay-Tee, Ballantyne Christie M., Catapano Alberico L., Reiner Željko, Lüscher Thomas F. The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011 European heart journal 2014;35 (15):960-968 [PubMed]
• Friedrich S., Kastelein J. J. P., James D., Waterhouse T., Nissen S. E., Nicholls S. J., Krueger K. A. The pharmacokinetics and pharmacokinetic/pharmacodynamic relationships of evacetrapib administered as monotherapy or in combination with statins CPT: pharmacometrics & systems pharmacology 2014;3:e94 [PubMed]
• Braamskamp Marjet J. A. M., Roelants Roosje J., Hutten Barbara A., Kastelein John J. P. The role of rosuvastatin in the treatment of pediatric homozygous familial hypercholesterolemia Expert opinion on orphan drugs 2014;2 (12):1325-1330
• Sattar Naveed A., Ginsberg Henry, Ray Kausik, Chapman M. John, Arca Marcello, Averna Maurizio, Betteridge D. John, Bhatnagar Deepak, Bilianou Elena, Carmena Rafael, Ceška Richard, Corsini Alberto, Erbel Raimund, Flynn Paul D., Garcia-Moll Xavier, Gumprecht Janusz, Ishibashi Shun, Jambart Selim, Kastelein John J. P., Maher Vincent, da Silva Pedro Marques, Masana Luis, Odawara Masato, Pedersen Terje R., Rotella Carlo Maria, Salti Ibrahim, Teramoto Tamio, Tokgozoglu Lale, Toth Peter P., Valensi Paul, Vergès Bruno The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice Atherosclerosis. Supplements 2014;15 (1):1-15 [PubMed]
• Ford John, Lawson Matt, Fowler David, Maruyama Nobuko, Mito Seiji, Tomiyasu Koichi, Kinoshita Shuji, Suzuki Chisa, Kawaguchi Atsuhiro, Round Patrick, Boyce Malcolm, Warrington Steve, Weber Werner, van Deventer Sander, Kastelein John J. P. Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects British journal of clinical pharmacology 2014;78 (3):498-508 [PubMed]
• Niesor Eric J., Kallend David, Bentley Darren, Kastelein John J. P., Kees Hovingh G., Stroes Erik S. G. Treatment of low HDL-C subjects with the CETP modulator dalcetrapib increases plasma campesterol only in those without ABCA1 and/or ApoA1 mutations Lipids 2014;49 (12):1245-1249 [PubMed]
• Teeuw Wijnand J., Slot Dagmar E., Susanto Hendri, Gerdes Victor E. A., Abbas Frank, D'Aiuto Francesco, Kastelein John J. P., Loos Bruno G. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis Journal of clinical periodontology 2014;41 (1):70-79 [PubMed]
• Bochem A. E., van Capelleveen J. C., Dallinga-Thie G. M., Schimmel A. W. M., Motazacker M. M., Tietjen I., Singaraja R. R., Hayden M. R., Kastelein J. J. P., Stroes E. S. G., Hovingh G. K. Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families Clinical genetics 2014;85 (5):433-440 [PubMed]
• Nicholls Stephen J., Kastelein John J. P., Schwartz Gregory G., Bash Dianna, Rosenson Robert S., Cavender Matthew A., Brennan Danielle M., Koenig Wolfgang, Jukema J. Wouter, Nambi Vijay, Wright R. Scott, Menon Venu, Lincoff A. Michael, Nissen Steven E., Hennekens Charles, Brown W. Virgil, DeMets David, Pfeffer Marc, Roleau John, Abraham JoEllyn, Gebel James, Huff Christopher, Katzan Irene, Shishehbor Medhi, Rassi Andrew, Uchino Ken, Vest Amanda, Zishiri Edwin, Heckman Mary Jo, Balog Craig, Dart Anthony, Amerena John, Prasad Challa, Farshid Ahmad, Gunalingam Brendan, Thompson Peter, Collins Nicholas, Arstall Margaret, van Gaal William, Aroney Con, Mahar Leo, Youssef George, Horowitz John, Anand Dharmesh, Rodes-Cabau Josep, Polasek Petr, Lai Christopher, Huynh Thao, Hubacek Jaroslav, Trip Mieke D. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial JAMA 2014;311 (3):252-262 [PubMed]
• Boekholdt S. Matthijs, Hovingh G. Kees, Mora Samia, Arsenault Benoit J., Amarenco Pierre, Pedersen Terje R., LaRosa John C., Waters David D., Demicco David A., Simes R. John, Keech Antony C., Colquhoun David, Hitman Graham A., Betteridge D. John, Clearfield Michael B., Downs John R., Colhoun Helen M., Gotto Antonio M., Ridker Paul M., Grundy Scott M., Kastelein John J. P. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials Journal of the American College of Cardiology 2014;64 (5):485-494 [PubMed]

2013

• Bochem Andrea E., van Wijk Diederik F., Holleboom Adriaan G., Duivenvoorden Raphaël, Motazacker Mahdi M., Dallinga-Thie Geesje M., de Groot Eric, Kastelein John J. P., Nederveen Aart J., Hovingh G. Kees, Stroes Erik S. G. ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden European heart journal 2013;34 (4):286-291 [PubMed]
• Waters David D., Ho Jennifer E., Boekholdt S. Matthijs, Demicco David A., Kastelein John J. P., Messig Michael, Breazna Andrei, Pedersen Terje R. Cardiovascular event reduction versus new-onset diabetes during atorvastatin therapy: effect of baseline risk factors for diabetes Journal of the American College of Cardiology 2013;61 (2):148-152 [PubMed]
• Rosenstock Julio, Marx Nikolaus, Kahn Steven E., Zinman Bernard, Kastelein John J., Lachin John M., Bluhmki Erich, Patel Sanjay, Johansen Odd-Erik, Woerle Hans-Jürgen Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA trial Diabetes & vascular disease research 2013;10 (4):289-301 [PubMed]
• Avis Hans J. Childhood initiated statin therapy in familial hypercholesterolemia 2013. 256p. ISBN 9789090277724. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Wijburg F. A.; Co-supervisors: Hutten B. A., Vissers M. N., Wiegman A.)
• Sondermeijer Brigitte M., Boekholdt S. Matthijs, Rana Jamal S., Kastelein John J. P., Wareham Nicholas J., Khaw Kay-Tee Clinical implications of JUPITER in a contemporary European population: the EPIC-Norfolk prospective population study European heart journal 2013;34 (18):1350-1357 [PubMed]
• Do Ron, Willer Cristen J., Schmidt Ellen M., Sengupta Sebanti, Gao Chi, Peloso Gina M., Gustafsson Stefan, Kanoni Stavroula, Ganna Andrea, Chen Jin, Buchkovich Martin L., Mora Samia, Beckmann Jacques S., Bragg-Gresham Jennifer L., Chang Hsing-Yi, Demirkan Ayşe, den Hertog Heleen M., Donnelly Louise A., Ehret Georg B., Esko Tõnu, Feitosa Mary F., Ferreira Teresa, Fischer Krista, Fontanillas Pierre, Fraser Ross M., Freitag Daniel F., Gurdasani Deepti, Heikkilä Kauko, Hyppönen Elina, Isaacs Aaron, Jackson Anne U., Johansson Asa, Johnson Toby, Kaakinen Marika, Kettunen Johannes, Kleber Marcus E., Li Xiaohui, Luan Jian'an, Lyytikäinen Leo-Pekka, Magnusson Patrik K. E., Mangino Massimo, Mihailov Evelin, Montasser May E., Müller-Nurasyid Martina, Nolte Ilja M., O'Connell Jeffrey R., Palmer Cameron D., Perola Markus, Petersen Ann-Kristin, Sanna Serena, Saxena Richa, Service Susan K., Shah Sonia, Shungin Dmitry, Sidore Carlo, Song Ci, Strawbridge Rona J., Surakka Ida, Tanaka Toshiko, Teslovich Tanya M., Thorleifsson Gudmar, van den Herik Evita G., Voight Benjamin F., Volcik Kelly A., Waite Lindsay L., Wong Andrew, Wu Ying, Zhang Weihua, Absher Devin, Asiki Gershim, Barroso Inês, Been Latonya F., Bolton Jennifer L., Bonnycastle Lori L., Brambilla Paolo, Burnett Mary S., Cesana Giancarlo, Dimitriou Maria, Doney Alex S. F., Döring Angela, Elliott Paul, Epstein Stephen E., Eyjolfsson Gudmundur Ingi, Gigante Bruna, Goodarzi Mark O., Grallert Harald, Gravito Martha L., Groves Christopher J., Hallmans Göran, Hartikainen Anna-Liisa, Hayward Caroline, Hernandez Dena, Hicks Andrew A., Holm Hilma, Hung Yi-Jen, Illig Thomas, Jones Michelle R., Kaleebu Pontiano, Kastelein John J. P., Khaw Kay-Tee, Kim Eric, Klopp Norman, Komulainen Pirjo, Kumari Meena, Langenberg Claudia, Lehtimäki Terho, Lin Shih-Yi, Lindström Jaana, Loos Ruth J. F., Mach François, McArdle Wendy L., Meisinger Christa, Mitchell Braxton D., Müller Gabrielle, Nagaraja Ramaiah, Narisu Narisu, Nieminen Tuomo V. M., Nsubuga Rebecca N., Olafsson Isleifur, Ong Ken K., Palotie Aarno, Papamarkou Theodore, Pomilla Cristina, Pouta Anneli, Rader Daniel J., Reilly Muredach P., Ridker Paul M., Rivadeneira Fernando, Rudan Igor, Ruokonen Aimo, Samani Nilesh, Scharnagl Hubert, Seeley Janet, Silander Kaisa, Stančáková Alena, Stirrups Kathleen, Swift Amy J., Tiret Laurence, Uitterlinden Andre G., van Pelt L. Joost, Vedantam Sailaja, Wainwright Nicholas, Wijmenga Cisca, Wild Sarah H., Willemsen Gonneke, Wilsgaard Tom, Wilson James F., Young Elizabeth H., Zhao Jing Hua, Adair Linda S., Arveiler Dominique, Assimes Themistocles L., Bandinelli Stefania, Bennett Franklyn, Bochud Murielle, Boehm Bernhard O., Boomsma Dorret I., Borecki Ingrid B., Bornstein Stefan R., Bovet Pascal, Burnier Michel, Campbell Harry, Chakravarti Aravinda, Chambers John C., Chen Yii-Der Ida, Collins Francis S., Cooper Richard S., Danesh John, Dedoussis George, de Faire Ulf, Feranil Alan B., Ferrières Jean, Ferrucci Luigi, Freimer Nelson B., Gieger Christian, Groop Leif C., Gudnason Vilmundur, Gyllensten Ulf, Hamsten Anders, Harris Tamara B., Hingorani Aroon, Hirschhorn Joel N., Hofman Albert, Hovingh G. Kees, Hsiung Chao Agnes, Humphries Steve E., Hunt Steven C., Hveem Kristian, Iribarren Carlos, Järvelin Marjo-Riitta, Jula Antti, Kähönen Mika, Kaprio Jaakko, Kesäniemi Antero, Kivimaki Mika, Kooner Jaspal S., Koudstaal Peter J., Krauss Ronald M., Kuh Diana, Kuusisto Johanna, Kyvik Kirsten O., Laakso Markku, Lakka Timo A., Lind Lars, Lindgren Cecilia M., Martin Nicholas G., März Winfried, McCarthy Mark I., McKenzie Colin A., Meneton Pierre, Metspalu Andres, Moilanen Leena, Morris Andrew D., Munroe Patricia B., Njølstad Inger, Pedersen Nancy L., Power Chris, Pramstaller Peter P., Price Jackie F., Psaty Bruce M., Quertermous Thomas, Rauramaa Rainer, Saleheen Danish, Salomaa Veikko, Sanghera Dharambir K., Saramies Jouko, Schwarz Peter E. H., Sheu Wayne H.-H., Shuldiner Alan R., Siegbahn Agneta, Spector Tim D., Stefansson Kari, Strachan David P., Tayo Bamidele O., Tremoli Elena, Tuomilehto Jaakko, Uusitupa Matti, van Duijn Cornelia M., Vollenweider Peter, Wallentin Lars, Wareham Nicholas J., Whitfield John B., Wolffenbuttel Bruce H. R., Altshuler David, Ordovas Jose M., Boerwinkle Eric, Palmer Colin N. A., Thorsteinsdottir Unnur, Chasman Daniel I., Rotter Jerome I., Franks Paul W., Ripatti Samuli, Cupples L. Adrienne, Sandhu Manjinder S., Rich Stephen S., Boehnke Michael, Deloukas Panos, Mohlke Karen L., Ingelsson Erik, Abecasis Goncalo R., Daly Mark J., Neale Benjamin M., Kathiresan Sekar Common variants associated with plasma triglycerides and risk for coronary artery disease Nature genetics 2013;45 (11):1345-1352 [PubMed]
• Ridker Paul M., Kastelein John J. P., Genest Jacques, Koenig Wolfgang C-reactive protein and cholesterol are equally strong predictors of cardiovascular risk and both are important for quality clinical care European heart journal 2013;34 (17):1258-1261 [PubMed]
• van Wijk Diederik F., Boekholdt S. Matthijs, Wareham Nicholas J., Ahmadi-Abhari Sara, Kastelein John J. P., Stroes Erik S. G., Khaw Kay-Tee C-Reactive Protein, Fatal and Nonfatal Coronary Artery Disease, Stroke, and Peripheral Artery Disease in the Prospective EPIC-Norfolk Cohort Study Arteriosclerosis, thrombosis, and vascular biology 2013;33 (12):2888-2894 [PubMed]
• Kusters D. Meeike, Hutten Barbarba A., McCrindle Brian W., Cassiman David, Francis Gordon A., Gagné Claude, Gaudet Daniel, Morrison Katherine M., Langslet Gisle, Kastelein John J., Wiegman Albert Design and baseline data of a pediatric study with rosuvastatin in familial hypercholesterolemia Journal of clinical lipidology 2013;7 (5):408-413 [PubMed]
• Duivenvoorden Raphaël, van Wijk Diederik, Klimas Michael, Kastelein John J. P., Stroes Erik S. G., Nederveen Aart J. Detection of liquid phase cholesteryl ester in carotid atherosclerosis by 1H-MR spectroscopy in humans JACC. Cardiovascular imaging 2013;6 (12):1277-1284 [PubMed]
• Hovingh G. Kees, Davidson Michael H., Kastelein John J. P., O'Connor Anne M. Diagnosis and treatment of familial hypercholesterolaemia European heart journal 2013;34 (13):962-971 [PubMed]
• Willer Cristen J., Schmidt Ellen M., Sengupta Sebanti, Peloso Gina M., Gustafsson Stefan, Kanoni Stavroula, Ganna Andrea, Chen Jin, Buchkovich Martin L., Mora Samia, Beckmann Jacques S., Bragg-Gresham Jennifer L., Chang Hsing-Yi, Demirkan Ayşe, den Hertog Heleen M., Do Ron, Donnelly Louise A., Ehret Georg B., Esko Tõnu, Feitosa Mary F., Ferreira Teresa, Fischer Krista, Fontanillas Pierre, Fraser Ross M., Freitag Daniel F., Gurdasani Deepti, Heikkilä Kauko, Hyppönen Elina, Isaacs Aaron, Jackson Anne U., Johansson Asa, Johnson Toby, Kaakinen Marika, Kettunen Johannes, Kleber Marcus E., Li Xiaohui, Luan Jian'an, Lyytikäinen Leo-Pekka, Magnusson Patrik K. E., Mangino Massimo, Mihailov Evelin, Montasser May E., Müller-Nurasyid Martina, Nolte Ilja M., O'Connell Jeffrey R., Palmer Cameron D., Perola Markus, Petersen Ann-Kristin, Sanna Serena, Saxena Richa, Service Susan K., Shah Sonia, Shungin Dmitry, Sidore Carlo, Song Ci, Strawbridge Rona J., Surakka Ida, Tanaka Toshiko, Teslovich Tanya M., Thorleifsson Gudmar, van den Herik Evita G., Voight Benjamin F., Volcik Kelly A., Waite Lindsay L., Wong Andrew, Wu Ying, Zhang Weihua, Absher Devin, Asiki Gershim, Barroso Inês, Been Latonya F., Bolton Jennifer L., Bonnycastle Lori L., Brambilla Paolo, Burnett Mary S., Cesana Giancarlo, Dimitriou Maria, Doney Alex S. F., Döring Angela, Elliott Paul, Epstein Stephen E., Eyjolfsson Gudmundur Ingi, Gigante Bruna, Goodarzi Mark O., Grallert Harald, Gravito Martha L., Groves Christopher J., Hallmans Göran, Hartikainen Anna-Liisa, Hayward Caroline, Hernandez Dena, Hicks Andrew A., Holm Hilma, Hung Yi-Jen, Illig Thomas, Jones Michelle R., Kaleebu Pontiano, Kastelein John J. P., Khaw Kay-Tee, Kim Eric, Klopp Norman, Komulainen Pirjo, Kumari Meena, Langenberg Claudia, Lehtimäki Terho, Lin Shih-Yi, Lindström Jaana, Loos Ruth J. F., Mach François, McArdle Wendy L., Meisinger Christa, Mitchell Braxton D., Müller Gabrielle, Nagaraja Ramaiah, Narisu Narisu, Nieminen Tuomo V. M., Nsubuga Rebecca N., Olafsson Isleifur, Ong Ken K., Palotie Aarno, Papamarkou Theodore, Pomilla Cristina, Pouta Anneli, Rader Daniel J., Reilly Muredach P., Ridker Paul M., Rivadeneira Fernando, Rudan Igor, Ruokonen Aimo, Samani Nilesh, Scharnagl Hubert, Seeley Janet, Silander Kaisa, Stancáková Alena, Stirrups Kathleen, Swift Amy J., Tiret Laurence, Uitterlinden Andre G., van Pelt L. Joost, Vedantam Sailaja, Wainwright Nicholas, Wijmenga Cisca, Wild Sarah H., Willemsen Gonneke, Wilsgaard Tom, Wilson James F., Young Elizabeth H., Zhao Jing Hua, Adair Linda S., Arveiler Dominique, Assimes Themistocles L., Bandinelli Stefania, Bennett Franklyn, Bochud Murielle, Boehm Bernhard O., Boomsma Dorret I., Borecki Ingrid B., Bornstein Stefan R., Bovet Pascal, Burnier Michel, Campbell Harry, Chakravarti Aravinda, Chambers John C., Chen Yii-Der Ida, Collins Francis S., Cooper Richard S., Danesh John, Dedoussis George, de Faire Ulf, Feranil Alan B., Ferrières Jean, Ferrucci Luigi, Freimer Nelson B., Gieger Christian, Groop Leif C., Gudnason Vilmundur, Gyllensten Ulf, Hamsten Anders, Harris Tamara B., Hingorani Aroon, Hirschhorn Joel N., Hofman Albert, Hovingh G. Kees, Hsiung Chao Agnes, Humphries Steve E., Hunt Steven C., Hveem Kristian, Iribarren Carlos, Järvelin Marjo-Riitta, Jula Antti, Kähönen Mika, Kaprio Jaakko, Kesäniemi Antero, Kivimaki Mika, Kooner Jaspal S., Koudstaal Peter J., Krauss Ronald M., Kuh Diana, Kuusisto Johanna, Kyvik Kirsten O., Laakso Markku, Lakka Timo A., Lind Lars, Lindgren Cecilia M., Martin Nicholas G., März Winfried, McCarthy Mark I., McKenzie Colin A., Meneton Pierre, Metspalu Andres, Moilanen Leena, Morris Andrew D., Munroe Patricia B., Njølstad Inger, Pedersen Nancy L., Power Chris, Pramstaller Peter P., Price Jackie F., Psaty Bruce M., Quertermous Thomas, Rauramaa Rainer, Saleheen Danish, Salomaa Veikko, Sanghera Dharambir K., Saramies Jouko, Schwarz Peter E. H., Sheu Wayne H.-H., Shuldiner Alan R., Siegbahn Agneta, Spector Tim D., Stefansson Kari, Strachan David P., Tayo Bamidele O., Tremoli Elena, Tuomilehto Jaakko, Uusitupa Matti, van Duijn Cornelia M., Vollenweider Peter, Wallentin Lars, Wareham Nicholas J., Whitfield John B., Wolffenbuttel Bruce H. R., Ordovas Jose M., Boerwinkle Eric, Palmer Colin N. A., Thorsteinsdottir Unnur, Chasman Daniel I., Rotter Jerome I., Franks Paul W., Ripatti Samuli, Cupples L. Adrienne, Sandhu Manjinder S., Rich Stephen S., Boehnke Michael, Deloukas Panos, Kathiresan Sekar, Mohlke Karen L., Ingelsson Erik, Abecasis Gonçalo R. Discovery and refinement of loci associated with lipid levels Nature genetics 2013;45 (11):1274-1283 [PubMed]
• Nicholls Stephen J., Bakris George L., Kastelein John J. P., Menon Venu, Williams Bryan, Armbrecht Juergen, Brunel Patrick, Nicolaides Maria, Hsu Amy, Hu Bo, Fang Hui, Puri Rishi, Uno Kiyoko, Kataoka Yu, Bash Dianna, Nissen Steven E. Effect of Aliskiren on Progression of Coronary Disease in Patients With Prehypertension The AQUARIUS Randomized Clinical Trial JAMA 2013;310 (11):1135-1144 [PubMed]
• Tikkanen Matti J., Fayyad Rana, Faergeman Ole, Olsson Anders G., Wun Chuan-Chuan, Laskey Rachel, Kastelein John J., Holme Ingar, Pedersen Terje R. Effect of intensive lipid lowering with atorvastatin on cardiovascular outcomes in coronary heart disease patients with mild-to-moderate baseline elevations in alanine aminotransferase levels International journal of cardiology 2013;168 (4):3846-3852 [PubMed]
• Brinton Eliot A., Ballantyne Christie M., Bays Harold E., Kastelein John J., Braeckman Rene A., Soni Paresh N. Effects of icosapent ethyl on lipid and inflammatory parameters in patients with diabetes mellitus-2, residual elevated triglycerides (200-500 mg/dL), and on statin therapy at LDL-C goal: the ANCHOR study Cardiovascular diabetology 2013;12 (1):100 [PubMed]
• Hovingh Kees, Besseling Joost, Kastelein John Efficacy and safety of mipomersen sodium (Kynamro) Expert opinion on drug safety 2013;12 (4):569-579 [PubMed]
• Stitziel Nathan O., Fouchier Sigrid W., Sjouke Barbara, Peloso Gina M., Moscoso Alessa M., Auer Paul L., Goel Anuj, Gigante Bruna, Barnes Timothy A., Melander Olle, Orho-Melander Marju, Duga Stefano, Sivapalaratnam Suthesh, Nikpay Majid, Martinelli Nicola, Girelli Domenico, Jackson Rebecca D., Kooperberg Charles, Lange Leslie A., Ardissino Diego, McPherson Ruth, Farrall Martin, Watkins Hugh, Reilly Muredach P., Rader Daniel J., de Faire Ulf, Schunkert Heribert, Erdmann Jeanette, Samani Nilesh J., Charnas Lawrence, Altshuler David, Gabriel Stacey, Kastelein John J. P., Defesche Joep C., Nederveen Aart J., Kathiresan Sekar, Hovingh G. Kees Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia Arteriosclerosis, thrombosis, and vascular biology 2013;33 (12):2909-2914 [PubMed]
• Kastelein John J. P., Ross Colin J. D., Hayden Michael R. From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world Human gene therapy 2013;24 (5):472-478 [PubMed]
• Guo Yiran, Lanktree Matthew B., Taylor Kira C., Hakonarson Hakon, Lange Leslie A., Keating Brendan J., Fairfax Benjamin P., Elbers Clara C., Barnard John, Farrall Martin, Padmanabhan Sandosh, Baumert Jens, Castillo Berta A., Gaunt Tom R., Gong Yan, Rajagopalan Ramakrishnan, Romaine Simon P. R., Kumari Meena, Rafelt Suzanne, Smith Erin N., Li Yun R., Sivapalaratnam Suthesh, van Iperen Erik P. A., Speliotes Elizabeth K., Toskala Elina, Zhang Li, Ochs-Balcom Heather M., Bhangale Tushar R., Chandrupatla Hareesh R., Drenos Fotios, Gieger Christian, Gupta Jayanta, Johnson Toby, Kleber Marcus E., Makino Seiko, Mangino Massimo, Meng Yan, Nelson Christopher P., Pankow James S., Pankratz Nathan, Price Tom S., Shaffer Jonathan, Bezzina Connie R., Chen Wei, de Jong Jonas S., Zafarmand Mohammad H., Zwinderman Aeilko H., Hovingh Kees G., Kastelein John J. P., Trip Mieke D. Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals Human molecular genetics 2013;22 (1):184-201 [PubMed]
• van Capelleveen Julian C., Bochem Andrea E., Motazacker M. Mahdi, Hovingh G. Kees, Kastelein John J. P. Genetics of HDL-C: a causal link to atherosclerosis? Current atherosclerosis reports 2013;15 (6):326 [PubMed]
• Westerink Jan, Deanfield John E., Imholz Ben P., Spiering Wilko, Basart Dick C., Coll Blai, Kastelein John J. P., Visseren Frank L. J. High-dose statin monotherapy versus low-dose statin/ezetimibe combination on fasting and postprandial lipids and endothelial function in obese patients with the metabolic syndrome: The PANACEA study Atherosclerosis 2013;227 (1):118-124 [PubMed]
• Dorresteijn Johannes A. N., Boekholdt S. Matthijs, van der Graaf Yolanda, Kastelein John J. P., LaRosa John C., Pedersen Terje R., Demicco David A., Ridker Paul M., Cook Nancy R., Visseren Frank L. J. High-dose statin therapy in patients with stable coronary artery disease: treating the right patients based on individualized prediction of treatment effect Circulation 2013;127 (25):2485-2493 [PubMed]
• Sorrentino Vincenzo, Fouchier Sigrid W., Motazacker Mohammad M., Nelson Jessica K., Defesche Joep C., Dallinga-Thie Geesje M., Kastelein John J. P., Kees Hovingh G., Zelcer Noam Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein European heart journal 2013;34 (17):1292-1297 [PubMed]
• Kusters D. Meeike, Avis Hans J., Braamskamp Marjet J., Huijgen Roeland, Wijburg Frits A., Kastelein John J., Wiegman Albert, Hutten Barbara A. Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk Journal of lipid research 2013;54 (9):2543-2549 [PubMed]
• Duivenvoorden Raphaël Innovative imaging techniques for improved characterization of atherosclerosis and the assessment of novel therapies 2013. 301p. ISBN 9789090277722. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Stroes E. S. G.; Co-supervisors: Nederveen A. J., de Groot E., Mulder W. J. M.)
• Stalenhoef Anton F., Kastelein John J. P. introduction Current opinion in lipidology 2013;24 (6):534-535
• Holleboom Adriaan G., Jakulj Lily, Franssen Remco, Decaris Julie, Vergeer Menno, Koetsveld Joris, Luchoomun Jayraz, Glass Alexander, Hellerstein Marc K., Kastelein John J. P., Hovingh G. Kees, Kuivenhoven Jan Albert, Groen Albert K., Turner Scott M., Stroes Erik S. G. In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1 Journal of lipid research 2013;54 (7):1964-1971 [PubMed]
• Besseling Joost, van Capelleveen Julian, Kastelein John J. P., Hovingh G. Kees LDL cholesterol goals in high-risk patients: how low do we go and how do we get there? Drugs 2013;73 (4):293-301 [PubMed]
• Boekholdt S. Matthijs, Arsenault Benoit J., Hovingh G. Kees, Mora Samia, Pedersen Terje R., LaRosa John C., Welch K. M. A., Amarenco Pierre, Demicco David A., Tonkin Andrew M., Sullivan David R., Kirby Adrienne, Colhoun Helen M., Hitman Graham A., Betteridge D. John, Durrington Paul N., Clearfield Michael B., Downs John R., Gotto Antonio M., Ridker Paul M., Kastelein John J. P. Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis Circulation 2013;128 (14):1504-1512 [PubMed]
• Ganesh Santhi K., Tragante Vinicius, Guo Wei, Guo Yiran, Lanktree Matthew B., Smith Erin N., Johnson Toby, Castillo Berta Almoguera, Barnard John, Baumert Jens, Chang Yen-Pei Christy, Elbers Clara C., Farrall Martin, Fischer Mary E., Franceschini Nora, Gaunt Tom R., Gho Johannes M. I. H., Gieger Christian, Gong Yan, Isaacs Aaron, Kleber Marcus E., Mateo Leach Irene, McDonough Caitrin W., Meijs Matthijs F. L., Mellander Olle, Molony Cliona M., Nolte Ilja M., Padmanabhan Sandosh, Price Tom S., Rajagopalan Ramakrishnan, Shaffer Jonathan, Shah Sonia, Shen Haiqing, Soranzo Nicole, van der Most Peter J., van Iperen Erik P. A., van Setten Jessic A., Vonk Judith M., Zhang Li, Beitelshees Amber L., Berenson Gerald S., Bhatt Deepak L., Boer Jolanda M. A., Boerwinkle Eric, Burkley Ben, Burt Amber, Chakravarti Aravinda, Chen Wei, Cooper-DeHoff Rhonda M., Curtis Sean P., Dreisbach Albert, Duggan David, Ehret Georg B., Fabsitz Richard R., Fornage Myriam, Fox Ervin, Furlong Clement E., Gansevoort Ron T., Hofker Marten H., Hovingh G. Kees, Kirkland Susan A., Kottke-Marchant Kandice, Kutlar Abdullah, LaCroix Andrea Z., Langaee Taimour Y., Li Yun R., Lin Honghuang, Liu Kiang, Maiwald Steffi, Malik Rainer, Murugesan Gurunathan, Newton-Cheh Christopher, O'Connell Jeffery R., Onland-Moret N. Charlotte, Ouwehand Willem H., Palmas Walter, Penninx Brenda W., Pepine Carl J., Pettinger Mary, Polak Joseph F., Ramachandran Vasan S., Ranchalis Jane, Redline Susan, Ridker Paul M., Rose Lynda M., Scharnag Hubert, Schork Nicholas J., Shimbo Daichi, Shuldiner Alan R., Srinivasan Sathanur R., Stolk Ronald P., Taylor Herman A., Thorand Barbara, Trip Mieke D., van Duijn Cornelia M., Verschuren W. Monique, Wijmenga Cisca, Winkelmann Bernhard R., Wyatt Sharon, Young J. Hunter, Boehm Bernhard O., Caulfield Mark J., Chasman Daniel I., Davidson Karina W., Doevendans Pieter A., FitzGerald Garret A., Gums John G., Hakonarson Hakon, Hillege Hans L., Illig Thomas, Jarvik Gail P., Johnson Julie A., Kastelein John J. P., Koenig Wolfgang, März Winfried, Mitchell Braxton D., Murray Sarah S., Oldehinkel Albertine J., Rader Daniel J., Reilly Muredach P., Reiner Alex P., Schadt Eric E., Silverstein Roy L., Snieder Harold, Stanton Alice V., Uitterlinden André G., van der Harst Pim, van der Schouw Yvonne T., Samani Nilesh J., Johnson Andrew D., Munroe Patricia B., de Bakker Paul I. W., Zhu Xiaofeng, Levy Daniel, Keating Brendan J., Asselbergs Folkert W. Loci influencing blood pressure identified using a cardiovascular gene-centric array Human molecular genetics 2013;22 (8):1663-1678 [PubMed]
• Oosterveer Daniëlla M., Versmissen Jorie, Defesche Joep C., Sivapalaratnam Suthesh, Yazdanpanah Mojgan, Mulder Monique, van der Zee Leonie, Uitterlinden André G., van Duijn Cornelia M., Hofman Albert, Kastelein John J. P., Aulchenko Yurii S., Sijbrands Eric J. G. Low-density lipoprotein receptor mutations generate synthetic genome-wide associations European journal of human genetics 2013;21 (5):563-566 [PubMed]
• Sondermeijer Brigitte M., Rana Jamal S., Arsenault Benoit J., Shah Prediman K., Kastelein John J. P., Wareham Nicholas J., Boekholdt S. Matthijs, Khaw Kay-Tee Non-HDL cholesterol vs. apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study European journal of clinical investigation 2013;43 (10):1009-1015 [PubMed]
• Rashid Shirya, Kastelein John J. P. PCSK9 and resistin at the crossroads of the atherogenic dyslipidemia Expert review of cardiovascular therapy 2013;11 (11):1567-1577 [PubMed]
• Huijgen Roeland, Boekholdt S. Matthijs, Arsenault Benoit J., Bao Weihang, Davaine Jean-Michel, Tabet Fatiha, Petrides Francine, Rye Kerry-Anne, Demicco David A., Barter Philip J., Kastelein John J. P., Lambert Gilles Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) Trial (Retraction of vol 59, pg 1778, 2012) Journal of the American College of Cardiology 2013;61 (16):1751
• Arsenault Benoit J., Barter Philip, Demicco David A., Bao Weihang, Preston Gregory M., LaRosa John C., Grundy Scott M., Deedwania Prakash, Greten Heiner, Wenger Nanette K., Shepherd James, Waters David D., Kastelein John J. P. Prediction of cardiovascular events in statin-treated patients by lipid and non-lipid biomarkers (Retraction of vol 57, pg 63, 2011) Journal of the American College of Cardiology 2013;61 (16):1750
• Stoekenbroek Robert M., Kastelein John J. P., Hovingh G. Kees Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs Current opinion in lipidology 2013;24 (6):459-466 [PubMed]
• Scirica Benjamin M., Bhatt Deepak L., Braunwald Eugene, Steg P. Gabriel, Davidson Jaime, Hirshberg Boaz, Ohman Peter, Frederich Robert, Wiviott Stephen D., Hoffman Elaine B., Cavender Matthew A., Udell Jacob A., Desai Nihar R., Mosenzon Ofri, McGuire Darren K., Ray Kausik K., Leiter Lawrence A., Raz Itamar, Desai Nihar, Abrahamsen Timothy, Grossman Michelle, Morin Suzanne, Im KyungAh, Hoffman Elaine, Gabovitch Daniel, Pricken Alexandra, Buskila Alona, Stahre Christina, Price Deborah, Billing-Clason Solveig, Sabel Karin, Monyak John, Sjöstrand Mikalea, Wei Cheryl, Lu Jane, Miller Elinor, Raichlen Joel, Fitt Sandy, Iqbal Nayyar, Donovan Mark, Davidson Jaime A., Steg Ph Gabriel, Aguilar-Salinas Carlos, Alvarsson Michael, Amerena John, Ardissino Diego, Hoekstra Joost, Kastelein John, Wang J., Nieuwdorp M. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus New England journal of medicine 2013;369 (14):1317-1326 [PubMed]
• Braamskamp Marjet J. A. M., Tsimikas Sotirios, Wiegman Albert, Kastelein John J. P., Hutten Barbara A. Statin therapy and secretory phospholipase A₂ in children with heterozygous familial hypercholesterolemia Atherosclerosis 2013;229 (2):404-407 [PubMed]
• Singaraja Roshni R., Sivapalaratnam Suthesh, Hovingh Kees, Dubé Marie-Pierre, Castro-Perez José, Collins Heidi L., Adelman Steven J., Riwanto Meliana, Manz Jasmin, Hubbard Brian, Tietjen Ian, Wong Kenny, Mitnaul Lyndon J., van Heek Margaret, Lin Linus, Roddy Thomas A., McEwen Jason, Dallinge-Thie Geesje, van Vark-van der Zee Leonie, Verwoert Germaine, Winther Michael, van Duijn Cornelia, Hofman Albert, Trip Mieke D., Marais A. David, Asztalos Bela, Landmesser Ulf, Sijbrands Eric, Kastelein John J., Hayden Michael R. The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans Circulation. Cardiovascular genetics 2013;6 (1):54-62 [PubMed]
• Charakida Marietta, de Groot Eric, Loukogeorgakis Stavros P., Khan Tauseef, Lüscher Thomas, Kastelein John J., Gasser Theo, Deanfield John E. Variability and reproducibility of flow-mediated dilatation in a multicentre clinical trial European heart journal 2013;34 (45):3501-3507 [PubMed]

2012

• Motazacker Mohammad Mahdi, Pirruccello James, Huijgen Roeland, Do Ron, Gabriel Stacey, Peter Jorge, Kuivenhoven Jan Albert, Defesche Joep C., Kastelein John J. P., Hovingh G. Kees, Zelcer Noam, Kathiresan Sekar, Fouchier Sigrid W. Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia European heart journal 2012;33 (11):1360-1366 [PubMed]
• Visser Maartje E., Witztum Joseph L., Stroes Erik S. G., Kastelein John J. P. Antisense oligonucleotides for the treatment of dyslipidaemia European heart journal 2012;33 (12):1451-1458 [PubMed]
• Nicholls Stephen J., Gordon Allan, Johannson Jan, Ballantyne Christie M., Barter Philip J., Brewer H. Bryan, Kastelein John J. P., Wong Norman C., Borgman Marilyn R. N., Nissen Steven E. ApoA-I Induction as a Potential Cardioprotective Strategy: Rationale for the SUSTAIN and ASSURE Studies Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2012;26 (2):181-187 [PubMed]
• Boekholdt S. Matthijs, Arsenault Benoit J., Mora Samia, Pedersen Terje R., LaRosa John C., Nestel Paul J., Simes R. John, Durrington Paul, Hitman Graham A., Welch K. M. A., Demicco David A., Zwinderman Aeilko H., Clearfield Michael B., Downs John R., Tonkin Andrew M., Colhoun Helen M., Gotto Antonio M., Ridker Paul M., Kastelein John J. P. Association of LDL Cholesterol, Non-HDL Cholesterol, and Apolipoprotein B Levels With Risk of Cardiovascular Events Among Patients Treated With Statins A Meta-analysis JAMA 2012;307 (12):1302-1309 [PubMed]
• Tajik Parvin, Meijer Rudy, Duivenvoorden Raphaël, Peters Sanne A. E., Kastelein John J., Visseren Frank J., Crouse John R., Palmer Mike K., Raichlen Joel S., Grobbee Diederick E., Bots Michiel L. Asymmetrical distribution of atherosclerosis in the carotid artery: identical patterns across age, race, and gender European journal of preventive cardiology 2012;19 (4):687-697 [PubMed]
• Mulders Ties A., Sivapalaratnam Suthesh, Stroes Erik S. G., Kastelein John J. P., Guerci Alan D., Pinto-Sietsma Sara-Joan Asymptomatic Individuals With a Positive Family History for Premature Coronary Artery Disease and Elevated Coronary Calcium Scores Benefit From Statin Treatment A Post Hoc Analysis From the St. Francis Heart Study JACC. Cardiovascular imaging 2012;5 (3):252-260 [PubMed]
• Sondermeijer Brigitte M. Cardiovascular metabolism 2012. 201p. ISBN 9789088914782. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Stroes E. S. G.; Co-supervisor: Serlie M. J. M.)
• Huijgen Roeland, Kindt Iris, Defesche Joep C., Kastelein John J. P. Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29 365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants European heart journal 2012;33 (18):2325-2330 [PubMed]
• Arsenault Benoit J., Boekholdt S. Matthijs, Tardif Jean-Claude, Kastelein John J. P. De-risking the clinical development of cholesteryl ester transfer protein inhibitors: how much is good enough? European heart journal 2012;33 (13):1548-1550 [PubMed]
• Mora Samia, Wenger Nanette K., Demicco David A., Breazna Andrei, Boekholdt S. Matthijs, Arsenault Benoit J., Deedwania Prakash, Kastelein John J. P., Waters David D. Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) study Circulation 2012;125 (16):1979-1987 [PubMed]
• Brunham L. R., Lansberg P. J., Zhang L., Miao F., Carter C., Hovingh G. K., Visscher H., Jukema J. W., Stalenhoef A. F., Ross C. J. D., Carleton B. C., Kastelein J. J. P., Hayden M. R. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin pharmacogenomics journal 2012;12 (3):233-237 [PubMed]
• Huijgen Roeland, Hutten Barbara A., Kindt Iris, Vissers Maud N., Kastelein John J. P. Discriminative Ability of LDL-Cholesterol to Identify Patients With Familial Hypercholesterolemia Circulation. Cardiovascular genetics 2012;5 (3):354-359 [PubMed]
• Ballantyne Christie M., Bays Harold E., Kastelein John J., Stein Evan, Isaacsohn Jonathan L., Braeckman Rene A., Soni Paresh N. Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study) American journal of cardiology 2012;110 (7):984-992 [PubMed]
• Huijgen R., Stork A. D. M., Defesche J. C., Peter J., Alonso R., Cuevas A., Kastelein J. J. P., Duran M., Stroes E. S. G. Extreme xanthomatosis in patients with both familial hypercholesterolemia and cerebrotendinous xanthomatosis Clinical genetics 2012;81 (1):24-28 [PubMed]
• Huijgen Roeland Familial hypercholesterolemia: the Dutch approach 2012. 405p. ISBN 9789461083722. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., van Rijckevorsel J. L. A.; Co-supervisors: Hutten B. A., Vissers M. N.)
• Avis Hans J., Kusters D. Meeike, Vissers Maud N., Huijgen Roeland, Janssen Thomas H., Wiegman Albert, Kindt Iris, Kastelein John J. P., Wijburg Frits A., Hutten Barbara A. Follow-Up of Children Diagnosed with Familial Hypercholesterolemia in a National Genetic Screening Program Journal of pediatrics 2012;161 (1):99-103 [PubMed]
• Gaudet Daniel, Méthot Julie, Kastelein John Gene therapy for lipoprotein lipase deficiency Current opinion in lipidology 2012;23 (4):310-320 [PubMed]
• Huijgen Roeland, Sjouke Barbara, Vis Kelly, de Randamie Janine S. E., Defesche Joep C., Kastelein John J. P., Hovingh G. Kees, Fouchier Sigrid W. Genetic Variation in APOB, PCSK9, and ANGPTL3 in Carriers of Pathogenic Autosomal Dominant Hypercholesterolemic Mutations with Unexpected Low LDL-C Levels Human mutation 2012;33 (2):448-455 [PubMed]
• Clarke Robert, Bennett Derrick A., Parish Sarah, Verhoef Petra, Dötsch-Klerk Mariska, Lathrop Mark, Xu Peng, Nordestgaard Børge G., Holm Hilma, Hopewell Jemma C., Saleheen Danish, Tanaka Toshihiro, Anand Sonia S., Chambers John C., Kleber Marcus E., Ouwehand Willem H., Yamada Yoshiji, Elbers Clara, Peters Bas, Stewart Alexandre F. R., Reilly Muredach M., Thorand Barbara, Yusuf Salim, Engert James C., Assimes Themistocles L., Kooner Jaspal, Danesh John, Watkins Hugh, Samani Nilesh J., Collins Rory, Peto Richard, Holm H., Thorsteinsdottir U., Gretarsdottir S., Gulcher J. R., Thorgeirsson G., Andersen K., Stefansson K., Parish S., Bennett D. A., Clarke R., Peto R., Sleight P., Collins R., Hopewell J. C., Watkins H., Kastelein J. J., Trip M. D., Bezzina C. R., Maitland-van der Zee A. H. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias PLoS medicine 2012;9 (2):e1001177 [PubMed]
• Olivier Maryline, Tanck Michael W., Out Ruud, Villard Elise F., Lammers Bart, Bouchareychas Laura, Frisdal Eric, Superville Alexandre, van Berkel Theo, Kastelein John J., Eck Miranda Van, Jukema J. Wouter, Chapman M. John, Dallinga-Thie Geesje M., Guerin Maryse, Goff Wilfried Le Human ATP-Binding Cassette G1 Controls Macrophage Lipoprotein Lipase Bioavailability and Promotes Foam Cell Formation Arteriosclerosis, thrombosis, and vascular biology 2012;32 (9):2223-+ [PubMed]
• Bays Harold E., Braeckman Rene A., Ballantyne Christie M., Kastelein John J., Otvos James D., Stirtan William G., Soni Paresh N. Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study) Journal of clinical lipidology 2012;6 (6):565-572 [PubMed]
• Huijgen Roeland, Homsma Sietske J. M., Hutten Barbara A., Kindt Iris, Vissers Maud N., Kastelein John J. P., van Rijckevorsel Jan L. A. Improved access to life insurance after genetic diagnosis of familial hypercholesterolaemia: cross-sectional postal questionnaire study European journal of human genetics 2012;20 (7):722-728 [PubMed]
• Tietjen Ian, Hovingh G. Kees, Singaraja Roshni, Radomski Chris, McEwen Jason, Chan Elden, Mattice Maryanne, Legendre Annick, Kastelein John J. P., Hayden Michael R. Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2012;1821 (3):416-424 [PubMed]
• Landmesser Ulf, von Eckardstein Arnold, Kastelein John, Deanfield John, Lüscher Thomas F. Increasing high-density lipoprotein cholesterol by cholesteryl ester transfer protein-inhibition: a rocky road and lessons learned? The early demise of the dal-HEART programme European heart journal 2012;33 (14):1712-1715 [PubMed]
• Sondermeijer Brigitte M., Klein Twennaar Christian F., Kastelein John J. P., Franssen Eric J. F., Hutten Barbara A., Dallinga-Thie Geesje M., Stroes Erik S. G., Fliers Eric, Twickler Marcel T. B., Serlie Mireille J. Infusion of a Lipid Emulsion in Healthy Men Decreases the Serotonergic Response Neuroendocrinology 2012;95 (4):325-331 [PubMed]
• Nicholls Stephen J., Cavender Matthew A., Kastelein John J. P., Schwartz Gregory, Waters David D., Rosenson Robert S., Bash Dianna, Hislop Colin Inhibition of Secretory Phospholipase A(2) in Patients with Acute Coronary Syndromes: Rationale and Design of the Vascular Inflammation Suppression to Treat Acute Coronary Syndrome for 16 Weeks (VISTA-16) Trial Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2012;26 (1):71-75 [PubMed]
• Sarwar Nadeem, Butterworth Adam S., Freitag Daniel F., Gregson John, Willeit Peter, Gorman Donal N., Gao Pei, Saleheen Danish, Rendon Augusto, Nelson Christopher P., Braund Peter S., Hall Alistair S., Chasman Daniel I., Tybjærg-Hansen Anne, Chambers John C., Benjamin Emelia J., Franks Paul W., Clarke Robert, Wilde Arthur A. M., Trip Mieke D., Steri Maristella, Witteman Jacqueline C. M., Qi Lu, van der Schoot C. Ellen, de Faire Ulf, Erdmann Jeanette, Stringham Heather M., Koenig Wolfgang, Rader Daniel J., Melzer David, Reich David, Psaty Bruce M., Kleber Marcus E., Panagiotakos Demosthenes B., Willeit Johann, Wennberg Patrik, Woodward Mark, Adamovic Svetlana, Rimm Eric B., Meade Tom W., Gillum Richard F., Shaffer Jonathan A., Hofman Albert, Onat Altan, Kastelein John J. P., Motazacker Mahdi, de Jong Jonas S. S. G., Dekker Lucas R. C., Tanck Michael, Bezzina Connie R. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies Lancet 2012;379 (9822):1205-1213 [PubMed]
• Nieuwkerk Pythia T., Nierman Melchior C., Vissers Maud N., Locadia Mirjam, Greggers-Peusch Phillip, Knape Léon P. M., Kastelein John J. P., Sprangers Mirjam A. G., de Haes Hanneke C., Stroes Erik S. G. Intervention to Improve Adherence to Lipid-Lowering Medication and Lipid-Levels in Patients With an Increased Cardiovascular Risk American journal of cardiology 2012;110 (5):666-672 [PubMed]
• Asselbergs Folkert W., Guo Yiran, van Iperen Erik P. A., Sivapalaratnam Suthesh, Tragante Vinicius, Lanktree Matthew B., Lange Leslie A., Almoguera Berta, Appelman Yolande E., Barnard John, Baumert Jens, Beitelshees Amber L., Bhangale Tushar R., Chen Yii-Der Ida, Gaunt Tom R., Gong Yan, Hopewell Jemma C., Johnson Toby, Kleber Marcus E., Langaee Taimour Y., Li Mingyao, Li Yun R., Liu Kiang, McDonough Caitrin W., Meijs Matthijs F. L., Middelberg Rita P. S., Musunuru Kiran, Nelson Christopher P., O'Connell Jeffery R., Padmanabhan Sandosh, Pankow James S., Pankratz Nathan, Rafelt Suzanne, Rajagopalan Ramakrishnan, Romaine Simon P. R., Schork Nicholas J., Shaffer Jonathan, Shen Haiqing, Smith Erin N., Tischfield Sam E., van der Most Peter J., van Vliet-Ostaptchouk Jana V., Verweij Niek, Chen Wei, Zwinderman A. H., Bezzina Connie R., Trip Mieke D., Wilde Arthur A. M., Hovingh G. Kees, Kastelein John J. P. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci American journal of human genetics 2012;91 (5):823-838 [PubMed]
• Holleboom Adriaan G., Daniil Georgios, Fu Xiaoming, Zhang Renliang, Hovingh G. Kees, Schimmel Alinda W., Kastelein John J. P., Stroes Erik S. G., Witztum Joseph L., Hutten Barbara A., Tsimikas Sotirios, Hazen Stanley L., Chroni Angeliki, Kuivenhoven Jan Albert Lipid Oxidation in Carriers of Lecithin: Cholesterol Acyltransferase Gene Mutations Arteriosclerosis, thrombosis, and vascular biology 2012;32 (12):3066-+ [PubMed]
• Boekholdt S. Matthijs, Kastelein John J. P. Lipid Parameters and Cardiovascular Events in Patients Taking Statins Reply JAMA 2012;308 (2):132-133
• Visser Maartje E., Wagener Gilbert, Baker Brenda F., Geary Richard S., Donovan Joanne M., Beuers Ulrich H. W., Nederveen Aart J., Verheij Joanne, Trip Mieke D., Basart Dick C. G., Kastelein John J. P., Stroes Erik S. G. Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial European heart journal 2012;33 (9):1142-1149 [PubMed]
• Sivapalaratnam Suthesh, Basart Hanneke, Watkins Nicholas A., Maiwald Stepanie, Rendon Augusto, Krishnan Unni, Sondermeijer Brigitte M., Creemers Esther E., Pinto-Sietsma Sara J., Hovingh Kees, Ouwehand Willem H., Kastelein John J. P., Goodall Alison H., Trip Mieke D. Monocyte Gene Expression Signature of Patients with Early Onset Coronary Artery Disease PLoS ONE 2012;7 (2):e32166 [PubMed]
• Surendran R. P., Visser M. E., Heemelaar S., Wang J., Peter J., Defesche J. C., Kuivenhoven J. A., Hosseini M., Péterfy M., Kastelein J. J. P., Johansen C. T., Hegele R. A., Stroes E. S. G., Dallinga-Thie G. M. Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia Journal of internal medicine 2012;272 (2):185-196 [PubMed]
• van Leuven Sander I., Mendez-Fernandez Yanice V., Wilhelm Ashley J., Wade Nekeithia S., Gabriel Curtis L., Kastelein John J., Stroes Erik S., Tak Paul P., Major Amy S. Mycophenolate mofetil but not atorvastatin attenuates atherosclerosis in lupus-prone LDLr-/- mice Annals of the rheumatic diseases 2012;71 (3):408-414 [PubMed]
• Dastani Zari, Hivert Marie-France, Timpson Nicholas, Perry John R. B., Yuan Xin, Scott Robert A., Henneman Peter, Heid Iris M., Kizer Jorge R., Lyytikäinen Leo-Pekka, Fuchsberger Christian, Tanaka Toshiko, Morris Andrew P., Small Kerrin, Isaacs Aaron, Beekman Marian, Coassin Stefan, Lohman Kurt, Qi Lu, Kanoni Stavroula, Pankow James S., Uh Hae-Won, Wu Ying, Bidulescu Aurelian, Rasmussen-Torvik Laura J., Greenwood Celia M. T., Ladouceur Martin, Grimsby Jonna, Manning Alisa K., Liu Ching-Ti, Kooner Jaspal, Mooser Vincent E., Vollenweider Peter, Kapur Karen A., Chambers John, Wareham Nicholas J., Langenberg Claudia, Frants Rune, Willems-Vandijk Ko, Oostra Ben A., Willems Sara M., Lamina Claudia, Winkler Thomas W., Psaty Bruce M., Tracy Russell P., Brody Jennifer, Fouchier Sigrid W., Hovingh G. Kees, Boekholdt S. Matthijs, Kastelein John J. P. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals PLoS genetics 2012;8 (3):e1002607 [PubMed]
• Mora Samia, Glynn Robert J., Boekholdt S. Matthijs, Nordestgaard Børge G., Kastelein John J. P., Ridker Paul M. On-Treatment Non-High-Density Lipoprotein Cholesterol, Apolipoprotein B, Triglycerides, and Lipid Ratios in Relation to Residual Vascular Risk After Treatment With Potent Statin Therapy JUPITER (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin) Journal of the American College of Cardiology 2012;59 (17):1521-1528 [PubMed]
• van den Bogaard Bas, Holleboom Adriaan G., Duivenvoorden Raphaël, Hutten Barbara A., Kastelein John J. P., Hovingh G. Kees, Kuivenhoven Jan Albert, Stroes Erik S. G., van den Born Bert-Jan H. Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness Atherosclerosis 2012;225 (2):481-485 [PubMed]
• Gitt Anselm K., Drexel Heinz, Feely John, Ferrières Jean, Gonzalez-Juanatey José R., Thomsen Kristian K., Leiter Lawrence A., Lundman Pia, da Silva Pedro M., Pedersen Terje, Wood David, Jünger Claus, Dellea Pam S., Sazonov Vasilisa, Chazelle François, Kastelein John J. P. Persistent lipid abnormalities in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada European journal of preventive cardiology 2012;19 (2):221-230 [PubMed]
• Chapman M. John, Kastelein John J. P. Pitavastatin: a new option for the reduction of cardiovascular risk factors Clinical lipidology 2012;7 (3 1):1
• Kastelein John J. P., Braamskamp Marjet Pitavastatin: an overview of the LIVES study Clinical lipidology 2012;7 (3 1):25-31
• Huijgen R., Fouchier S. W., Denoun M., Hutten B. A., Vissers M. N., Lambert G., Kastelein J. J. P. Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia Journal of lipid research 2012;53 (5):979-983 [PubMed]
• Huijgen Roeland, Boekholdt S. Matthijs, Arsenault Benoit J., Bao Weihang, Davaine Jean-Michel, Tabet Fatiha, Petrides Francine, Rye Kerry-Anne, Demicco David A., Barter Philip J., Kastelein John J. P., Lambert Gilles Plasma PCSK9 Levels and Clinical Outcomes in the TNT (Treating to New Targets) Trial (Retracted article. See vol. 61, pg. 1751, 2013) Journal of the American College of Cardiology 2012;59 (20):1778-1784 [PubMed]
• Bots Michiel L., Taylor Allen J., Kastelein John J. P., Peters Sanne A. E., den Ruijter Hester M., Tegeler Charles H., Baldassarre Damiano, Stein James H., O'Leary Daniel H., Revkin James H., Grobbee Diederick E. Rate of change in carotid intima-media thickness and vascular events: meta-analyses can not solve all the issues. A point of view Journal of hypertension 2012;30 (9):1690-1696 [PubMed]
• Barter Philip J., Rye Kerry-Anne, Beltangady Mohan S., Ports William C., Duggan William T., Boekholdt S. Matthijs, Demicco David A., Kastelein John J. P., Shear Charles L. Relationship between atorvastatin dose and the harm caused by torcetrapib Journal of lipid research 2012;53 (11):2436-2442 [PubMed]
• Versmissen Jorie, Oosterveer Daniëlla M., Blommesteijn-Touw Adriana C., van Vark-van der Zee Leonie, Vongpromek Ranitha, Mulder Monique, Sijbrands Eric J. G., Hoekstra Menno, Out Ruud, Berbée Jimmy F. P., Vanmierlo Tim, Defesche Joep C., Kastelein John J. P. Response to the Letter by Singh et al Regarding "Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations" Circulation. Cardiovascular genetics 2012;5 (2):E14 [PubMed]
• Tietjen Ian, Hovingh G. Kees, Singaraja Roshni R., Radomski Chris, Barhdadi Amina, McEwen Jason, Chan Elden, Mattice Maryanne, Legendre Annick, Franchini Patrick L., Dubé Marie-Pierre, Kastelein John J. P., Hayden Michael R. Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol PLoS ONE 2012;7 (8):e37437 [PubMed]
• Kusters D. Meeike, Lahsinoui Hajar Hassani, van de Post Joris A. M., Wiegman Albert, Wijburg Frits A., Kastelein John J. P., Hutten Barbara A. Statin use during pregnancy: a systematic review and meta-analysis Expert review of cardiovascular therapy 2012;10 (3):363-378 [PubMed]
• Arsenault Benoit J., Boekholdt S. Matthijs, Hovingh G. Kees, Hyde Craig L., Demicco David A., Chatterjee Aurobindo, Barter Philip, Deedwania Prakash, Waters David D., LaRosa John C., Pedersen Terje R., Kastelein John J. P. The 719Arg Variant of KIF6 and Cardiovascular Outcomes in Statin-Treated, Stable Coronary Patients of the Treating to New Targets and Incremental Decrease in End Points Through Aggressive Lipid-Lowering Prospective Studies Circulation. Cardiovascular genetics 2012;5 (1):51-57 [PubMed]
• Sivapalaratnam Suthesh The molecular basis of early onset cardiovascular disease 2012. 276p. ISBN 9789461083326. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Levi M. M., Kastelein J. J. P.; Co-supervisors: Trip M. D., Ouwehand W. H., Hovingh G. K.)
• Lambert Gilles, Sjouke Barbara, Choque Benjamin, Kastelein John J. P., Hovingh G. Kees The PCSK9 decade Journal of lipid research 2012;53 (12):2515-2524 [PubMed]
• Rana Jamal S., Boekholdt S. Matthijs, Kastelein John J. P., Shah Prediman K. The Role of Non-HDL Cholesterol in Risk Stratification for Coronary Artery Disease Current atherosclerosis reports 2012;14 (2):130-134 [PubMed]
• Lüscher Thomas F., Taddei Stefano, Kaski Juan-Carlos, Jukema J. Wouter, Kallend David, Münzel Thomas, Kastelein John J. P., Deanfield John E., Noll Georg, Mocetti Tiziano, Fichtlscherer Stephan, Drexel Heinz, Simon Alain, Trip Mieke D., Basart Dick C. G., Visseren Frank L. J., Liem A. H., van Kempen Wouter, Jonker Jan, Kose Vicdan, Lokhorst Bianca, Agous Irma, Tiebesl Jeroen, Hoogendijk Jacqueline, de Schipper Lenie Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial European heart journal 2012;33 (7):857-+ [PubMed]

2011

• Regieli Jakub J., Doevendans Pieter A., Grobbee Diederick E., Zwinderman Aeilko H., van der Graaf Yolanda, Kastelein John J. P., Jukema J. Wouter ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting Atherosclerosis 2011;218 (2):457-463 [PubMed]
• Côté Mélanie, Cartier Amélie, Reuwer Anne Q., Arsenault Benoit J., Lemieux Isabelle, Després Jean-Pierre, Wareham Nicholas J., Kastelein John J. P., Boekholdt S. Matthijs, Khaw Kay-Tee Adiponectin and risk of coronary heart disease in apparently healthy men and women (from the EPIC-Norfolk Prospective Population Study) American journal of cardiology 2011;108 (3):367-373 [PubMed]
• Versmissen Jorie, Oosterveer Daniëlla M., Yazdanpanah Mojgan, Mulder Monique, Dehghan Abbas, Defesche Joep C., Kastelein John J. P., Sijbrands Eric J. G. A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients European heart journal 2011;32 (4):469-475 [PubMed]
• Peden John F., Hopewell Jemma C., Saleheen Danish, Chambers John C., Hager Jorg, Soranzo Nicole, Collins Rory, Danesh John, Elliott Paul, Farrall Martin, Stirrups Kathy, Zhang Weihua, Hamsten Anders, Parish Sarah, Lathrop Mark, Watkins Hugh, Clarke Robert, Deloukas Panos, Kooner Jaspal S., Goel Anuj, Ongen Halit, Strawbridge Rona J., Heath Simon, Mälarstig Anders, Helgadottir Anna, Öhrvik John, Murtaza Muhammed, Potter Simon, Hunt Sarah E., Delepine Marc, Jalilzadeh Shapour, Axelsson Tomas, Syvanen Ann-Christine, Gwilliam Rhian, Bumpstead Suzannah, Gray Emma, Edkins Sarah, Folkersen Lasse, Kyriakou Theodosios, Franco-Cereceda Anders, Gabrielsen Anders, Seedorf Udo, Eriksson Per, Offer Alison, Bowman Louise, Sleight Peter, Armitage Jane, Peto Richard, Kastelein John J. P., Trip Mieke D. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease Nature genetics 2011;43 (4):339-344 [PubMed]
• Versmissen Jorie, Oosterveer Daniëlla M., Hoekstra Menno, Out Ruud, Berbée Jimmy F. P., Blommesteijn-Touw Adriana C., van Vark-van der Zee Leonie, Vongpromek Ranitha, Vanmierlo Tim, Defesche Joep C., Mulder Monique, Kastelein John J. P., Sijbrands Eric J. G. Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations Circulation. Cardiovascular genetics 2011;4 (6):655-660 [PubMed]
• Huijgen Roeland, Vissers Maud N., Kindt Iris, Trip Mieke D., de Groot Eric, Kastelein John J. P., Hutten Barbara A. Assessment of carotid atherosclerosis in normocholesterolemic individuals with proven mutations in the low-density lipoprotein receptor or apolipoprotein B genes Circulation. Cardiovascular genetics 2011;4 (4):413-417 [PubMed]
• Duivenvoorden Raphaël, Holleboom Adriaan G., van den Bogaard Bas, Nederveen Aart J., de Groot Eric, Hutten Barbara A., Schimmel Alinda W., Hovingh G. Kees, Kastelein John J. P., Kuivenhoven Jan Albert, Stroes Erik S. G. Cholesterol Acyltransferase Gene Mutations Have Accelerated Atherogenesis as Assessed by Carotid 3.0-T Magnetic Resonance Imaging Carriers of Lecithin Journal of the American College of Cardiology 2011;58 (24):2481-2487 [PubMed]
• Ridker Paul M., Koenig Wolfgang, Kastelein John J. P. C-reactive protein in the Heart Protection Study Lancet 2011;377 (9781):1918-1918; author reply 1919 [PubMed]
• O'Leary Daniel H., Reuwer Anne Q., Nissen Steven E., Després Jean-Pierre, Deanfield John E., Brown Michael W., Zhou Rong, Zabbatino Salvatore M., Job Bernard, Kastelein John J. P., Visseren Frank L. J., O'Leary Daniel, Nissen Steven, Cannon Christopher, Deanfield John, Akhras Ronald, Breger Laurie, Dufour Robert, Frohlich Jiri, Garrel Dominique, Habib Rafik, Leiter Lawrence, Pliamm Lew, Sohal Parmjit, Whitsitt Paul, Cottin Yves, Bonnet Jacques, Farnier Michel, Simon Alain, Trip Mieke, Kose Vicdan, Tiebesl Jeroen, Agous Irma, Wiersma-Maximova Antoaneta, de Schipper Lena, Timmerman Rob, Visseren Frank, Bak Annette, Basart Dick, Ros Emili, Salas Jordi, Civeira Fernando, Formiguera Xavier, Mesa Jordi, Pintó Xavier, McCollum Charles, Durrington Paul, Betteridge John, Chowdhury Tahseen, Kopelman Peter Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial Heart (British Cardiac Society) 2011;97 (14):1143-1150 [PubMed]
• Barter Philip J., Rye Kerry-Anne, Tardif Jean-Claude, Waters David D., Boekholdt S. Matthijs, Breazna Andrei, Kastelein John J. P. Effect of torcetrapib on glucose, insulin, and hemoglobin A1c in subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial Circulation 2011;124 (5):555-562 [PubMed]
• Nicholls Stephen J., Brewer H. Bryan, Kastelein John J. P., Krueger Kathryn A., Wang Ming-Dauh, Shao Mingyuan, Hu Bo, McErlean Ellen, Nissen Steven E. Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial JAMA 2011;306 (19):2099-2109 [PubMed]
• Nicholls Stephen J., Gordon Allan, Johansson Jan, Wolski Kathy, Ballantyne Christie M., Kastelein John J. P., Taylor Allen, Borgman Marilyn, Nissen Steven E. Efficacy and Safety of a Novel Oral Inducer of Apolipoprotein A-I Synthesis in Statin-Treated Patients With Stable Coronary Artery Disease A Randomized Controlled Trial Journal of the American College of Cardiology 2011;57 (9):1111-1119 [PubMed]
• Akdim Fatima, Tribble Diane L., Flaim Joann D., Yu Rosie, Su John, Geary Richard S., Baker Brenda F., Fuhr Rainard, Wedel Mark K., Kastelein John J. P. Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia European heart journal 2011;32 (21):2650-2659 [PubMed]
• Bays Harold E., Ballantyne Christie M., Kastelein John J., Isaacsohn Jonathan L., Braeckman Rene A., Soni Paresh N. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial) American journal of cardiology 2011;108 (5):682-690 [PubMed]
• Sjouke B., Kusters D. M., Kastelein J. J. P., Hovingh G. K. Familial hypercholesterolemia: present and future management Current cardiology reports 2011;13 (6):527-536 [PubMed]
• Kusters D. M., Huijgen R., Defesche J. C., Vissers M. N., Kindt I., Hutten B. A., Kastelein J. J. P. Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genes Netherlands heart journal 2011;19 (4):175-182 [PubMed]
• Holleboom Adriaan G. Genetic disorders of HDL metabolism: from model to mechanism 2011. 422p. ISBN 9789461081735. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Stroes E. S. G., Kastelein J. J. P.; Co-supervisors: Kuivenhoven J. A., Hovingh G. K.)
• Vergeer Menno, Korporaal Suzanne J. A., Franssen Remco, Meurs Illiana, Out Ruud, Hovingh G. Kees, Hoekstra Menno, Sierts Jeroen A., Dallinga-Thie Geesje M., Motazacker Mohammad Mahdi, Holleboom Adriaan G., van Berkel Theo J. C., Kastelein John J. P., van Eck Miranda, Kuivenhoven Jan Albert Genetic Variant of the Scavenger Receptor BI in Humans New England journal of medicine 2011;364 (2):136-145 [PubMed]
• Strawbridge Rona J., Dupuis Josée, Prokopenko Inga, Barker Adam, Ahlqvist Emma, Rybin Denis, Petrie John R., Travers Mary E., Bouatia-Naji Nabila, Dimas Antigone S., Nica Alexandra, Wheeler Eleanor, Chen Han, Voight Benjamin F., Taneera Jalal, Kanoni Stavroula, Peden John F., Turrini Fabiola, Gustafsson Stefan, Zabena Carina, Almgren Peter, Barker David J. P., Barnes Daniel, Dennison Elaine M., Eriksson Johan G., Eriksson Per, Eury Elodie, Folkersen Lasse, Fox Caroline S., Frayling Timothy M., Goel Anuj, Gu Harvest F., Horikoshi Momoko, Isomaa Bo, Jackson Anne U., Jameson Karen A., Kajantie Eero, Kerr-Conte Julie, Kuulasmaa Teemu, Kuusisto Johanna, Loos Ruth J. F., Luan Jian'an, Makrilakis Konstantinos, Manning Alisa K., Martínez-Larrad María Teresa, Narisu Narisu, Nastase Mannila Maria, Boekholdt S. Matthijs, Kastelein John J. P., Rosendaal Frits R. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes Diabetes 2011;60 (10):2624-2634 [PubMed]
• Sivapalaratnam S., Motazacker M. M., Maiwald S., Hovingh G. K., Kastelein J. J. P., Levi M. [=Marcel M.], Trip M. D., Dallinga-Thie G. M. Genome-wide association studies in atherosclerosis Current atherosclerosis reports 2011;13 (3):225-232 [PubMed]
• Chambers John C., Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N., van der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E., Coin Lachlan J., Deng Guohong, Gieger Christian, Heard-Costa Nancy L., Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an, Vidal Pedro Marques, Mateo Leach Irene, O'Reilly Paul F., Peden John F., Rahmioglu Nilufer, Soininen Pasi, Speliotes Elizabeth K., Yuan Xin, Thorleifsson Gudmar, Alizadeh Behrooz Z., Atwood Larry D., Borecki Ingrid B., Brown Morris J., Charoen Pimphen, Cucca Francesco, Das Debashish, de Geus Eco J. C., Dixon Anna L., Döring Angela, Ehret Georg, Eyjolfsson Gudmundur I., Farrall Martin, Forouhi Nita G., Friedrich Nele, Yang J., Fouchier S. W., Hovingh G. Kees, Boekholdt S. M., Kastelein J. J., Henneman P. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma Nature genetics 2011;43 (11):1131-U129 [PubMed]
• Broekhuizen Lysette N. Glycocalyx, cardiometabolic disease and inflammation 2011. 183p. ISBN 9789461082008. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Vink H.; Co-supervisors: Stroes E. S. G., Nieuwdorp M.)
• Vergeer A. M. H. HDL genes & HDL drugs 2011. 303p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Kuivenhoven J. A., Stroes E. S. G.)
• Holleboom Adriaan G., Karlsson Helen, Lin Ruei-Shiuan, Beres Thomas M., Sierts Jeroen A., Herman Daniel S., Stroes Erik S. G., Aerts Johannes M., Kastelein John J. P., Motazacker Mohammad M., Dallinga-Thie Geesje M., Levels Johannes H. M., Zwinderman Aeilko H., Seidman Jonathan G., Seidman Christine E., Ljunggren Stefan, Lefeber Dirk J., Morava Eva, Wevers Ron A., Fritz Timothy A., Tabak Lawrence A., Lindahl Mats, Hovingh G. Kees, Kuivenhoven Jan Albert Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man Cell metabolism 2011;14 (6):811-818 [PubMed]
• Holleboom Adriaan G., Kuivenhoven Jan A., Peelman Frank, Schimmel Alinda W., Peter Jorge, Defesche Joep C., Kastelein John J. P., Hovingh G. Kees, Stroes Erik S., Motazacker Mohammad Mahdi High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in The Netherlands: identification and characterization of eight novel mutations Human mutation 2011;32 (11):1290-1298 [PubMed]
• Huijgen Roeland, Kastelein John J. P., Meijers Joost C. M. Increased coagulation factor VIII activity in patients with familial hypercholesterolemia Blood 2011;118 (26):6990-6991 [PubMed]
• Rana Jamal S., Arsenault Benoit J., Després Jean-Pierre, Côté Mélanie, Talmud Philippa J., Ninio Ewa, Wouter Jukema J., Wareham Nicholas J., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women European heart journal 2011;32 (3):336-344 [PubMed]
• Schunkert Heribert, König Inke R., Kathiresan Sekar, Reilly Muredach P., Assimes Themistocles L., Holm Hilma, Preuss Michael, Stewart Alexandre F. R., Barbalic Maja, Gieger Christian, Absher Devin, Aherrahrou Zouhair, Allayee Hooman, Altshuler David, Anand Sonia S., Andersen Karl, Anderson Jeffrey L., Ardissino Diego, Ball Stephen G., Balmforth Anthony J., Barnes Timothy A., Becker Diane M., Becker Lewis C., Berger Klaus, Bis Joshua C., Boekholdt S. Matthijs, Boerwinkle Eric, Braund Peter S., Brown Morris J., Burnett Mary Susan, Buysschaert Ian, Carlquist John F., Chen Li, Cichon Sven, Codd Veryan, Davies Robert W., Dedoussis George, Dehghan Abbas, Demissie Serkalem, Devaney Joseph M., Diemert Patrick, Do Ron, Doering Angela, Eifert Sandra, Mokhtari Nour Eddine El, Ellis Stephen G., Elosua Roberto, Engert James C., Epstein Stephen E., de Faire Ulf, Fischer Marcus, Folsom Aaron R., Freyer Jennifer, Gigante Bruna, Girelli Domenico, Gretarsdottir Solveig, Gudnason Vilmundur, Gulcher Jeffrey R., Halperin Eran, Hammond Naomi, Hazen Stanley L., Hofman Albert, Horne Benjamin D., Illig Thomas, Iribarren Carlos, Jones Gregory T., Jukema J. Wouter, Kaiser Michael A., Kaplan Lee M., Kastelein John J. P., Khaw Kay-Tee, Knowles Joshua W., Kolovou Genovefa, Kong Augustine, Laaksonen Reijo, Lambrechts Diether, Leander Karin, Lettre Guillaume, Li Mingyao, Lieb Wolfgang, Loley Christina, Lotery Andrew J., Mannucci Pier M., Maouche Seraya, Martinelli Nicola, McKeown Pascal P., Meisinger Christa, Meitinger Thomas, Melander Olle, Merlini Pier Angelica, Mooser Vincent, Morgan Thomas, Mühleisen Thomas W., Muhlestein Joseph B., Münzel Thomas, Musunuru Kiran, Nahrstaedt Janja, Nelson Christopher P., Nöthen Markus M., Olivieri Oliviero, Patel Riyaz S., Patterson Chris C., Peters Annette, Peyvandi Flora, Qu Liming, Quyyumi Arshed A., Rader Daniel J., Rallidis Loukianos S., Rice Catherine, Rosendaal Frits R., Rubin Diana, Salomaa Veikko, Sampietro M. Lourdes, Sandhu Manj S., Schadt Eric, Schäfer Arne, Schillert Arne, Schreiber Stefan, Schrezenmeir Jürgen, Schwartz Stephen M., Siscovick David S., Sivananthan Mohan, Sivapalaratnam Suthesh, Smith Albert, Smith Tamara B., Snoep Jaapjan D., Soranzo Nicole, Spertus John A., Stark Klaus, Stirrups Kathy, Stoll Monika, Tang W. H. Wilson, Tennstedt Stephanie, Thorgeirsson Gudmundur, Thorleifsson Gudmar, Tomaszewski Maciej, Uitterlinden Andre G., van Rij Andre M., Voight Benjamin F., Wareham Nick J., Wells George A., Wichmann H.-Erich, Wild Philipp S., Willenborg Christina, Witteman Jaqueline C. M., Wright Benjamin J., Ye Shu, Zeller Tanja, Ziegler Andreas, Cambien Francois, Goodall Alison H., Cupples L. Adrienne, Quertermous Thomas, März Winfried, Hengstenberg Christian, Blankenberg Stefan, Ouwehand Willem H., Hall Alistair S., Deloukas Panos, Thompson John R., Stefansson Kari, Roberts Robert, Thorsteinsdottir Unnur, O'Donnell Christopher J., McPherson Ruth, Erdmann Jeanette, Samani Nilesh J. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Nature genetics 2011;43 (4):333-U153 [PubMed]
• Butterworth Adam S., Braund Peter S., Farrall Martin, Hardwick Robert J., Saleheen Danish, Peden John F., Soranzo Nicole, Chambers John C., Sivapalaratnam Suthesh, Kleber Marcus E., Keating Brendan, Qasim Atif, Klopp Norman, Erdmann Jeanette, Assimes Themistocles L., Ball Stephen G., Balmforth Anthony J., Barnes Timothy A., Basart Hanneke, Baumert Jens, Bezzina Connie R., Boerwinkle Eric, Boehm Bernhard O., Brocheton Jessy, Bugert Peter, Cambien Francois, Clarke Robert, Codd Veryan, Collins Rory, Couper David, Cupples L. Adrienne, de Jong Jonas S., Diemert Patrick, Ejebe Kenechi, Elbers Clara C., Elliott Paul, Fornage Myriam, Franzosi Maria-Grazia, Frossard Philippe, Garner Stephen, Goel Anuj, Kastelein John J. P., Wilde Arthur A. M., Trip Mieke D., Dekker Lukas R., Henriques José P., Koch Karel T., de Winter Robbert J., Boekholdt S. Matthijs, Maitland-van der Zee Anke-Hilse Large-scale gene-centric analysis identifies novel variants for coronary artery disease PLoS genetics 2011;7 (9):e1002260 [PubMed]
• Olsson Anders G., Lindahl Christina, Holme Ingar, Fayyad Rana, Faergeman Ole, Kastelein John J. P., Tikkanen Matti J., Larsen Mogens Lytken, Pedersen Terje R. LDL cholesterol goals and cardiovascular risk during statin treatment: the IDEAL study European journal of cardiovascular prevention and rehabilitation 2011;18 (2):262-269 [PubMed]
• Arsenault Benoit J., Boekholdt S. Matthijs, Kastelein John J. P. Lipid parameters for measuring risk of cardiovascular disease Nature reviews. Cardiology 2011;8 (4):197-206 [PubMed]
• Ryu Sung Kee, Hutten Barbara A., Vissers Maud N., Wiegman Albert, Kastelein John J. P., Tsimikas Sotirios Lipoprotein-associated phospholipase A(2) mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: Effect of pravastatin Journal of clinical lipidology 2011;5 (1):50-56 [PubMed]
• Versmissen Jorie, Botden Ilse P. G., Huijgen Roeland, Oosterveer Daniëlla M., Defesche Joep C., Heil Thea C., Muntz Anouk, Langendonk Janneke G., Schinkel Arend F. L., Kastelein John J. P., Sijbrands Eric J. G. Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality Atherosclerosis 2011;219 (2):690-693 [PubMed]
• Dogan Soner, Kastelein Johannes Jacob Pieter, Grobbee Diederick Egbertus, Bots Michiel Leonardus Mean common or mean maximum carotid intima-media thickness as primary outcome in lipid-modifying intervention studies Journal of atherosclerosis and thrombosis 2011;18 (11):946-957 [PubMed]
• van der Graaf Anouk, Avis Hans J., Kusters D. Meeike, Vissers Maud N., Hutten Barbara A., Defesche Joep C., Huijgen Roeland, Fouchier Sigrid W., Wijburg Frits A., Kastelein John J. P., Wiegman Albert Molecular Basis of Autosomal Dominant Hypercholesterolemia Assessment in a Large Cohort of Hypercholesterolemic Children Circulation 2011;123 (11):1167-1173 [PubMed]
• Brunham Liam R., Tietjen Ian, Bochem Andrea E., Singaraja Roshni R., Franchini Patrick L., Radomski Chris, Mattice Maryanne, Legendre Annick, Hovingh G. Kees, Kastelein John J. P., Hayden Michael R. Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans Clinical genetics 2011;79 (6):575-581 [PubMed]
• Franssen Remco, Monajemi Houshang, Stroes Erik S. G., Kastelein John J. P. Obesity and dyslipidemia Medical clinics of North America 2011;95 (5):893-902 [PubMed]
• van den Bogaard Bas, van den Born Bert-Jan H., Fayyad Rana, Waters David D., Demicco David A., LaRosa John C., Kastelein John J. P., Holme Ingar On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study European journal of clinical investigation 2011;41 (2):134-142 [PubMed]
• Broekhuizen Lysette N., Boekholdt S. Matthijs, Arsenault Benoit J., Despres Jean-Pierre, Stroes Erik S. G., Kastelein John J. P., Khaw Kay-Tee, Wareham Nicholas J. Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study European journal of cardiovascular prevention and rehabilitation 2011;18 (2):209-217 [PubMed]
• Waters David D., Ho Jennifer E., Demicco David A., Breazna Andrei, Arsenault Benoit J., Wun Chuan-Chuan, Kastelein John J., Colhoun Helen, Barter Philip Predictors of New-Onset Diabetes in Patients Treated With Atorvastatin Results From 3 Large Randomized Clinical Trials Journal of the American College of Cardiology 2011;57 (14):1535-1545 [PubMed]
• Reuwer Anne Q. Prolactin and vascular diseas; a first cautious assessment 2011. 223p. ISBN 9789088913136. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Twickler Th. B., Goffin V.)
• Holleboom A. G., Kuivenhoven J. A., van Olden C. C., Peter J., Schimmel A. W., Levels J. H., Valentijn R. M., Vos P., Defesche J. C., Kastelein J. J. P., Hovingh G. K., Stroes E. S. G., Hollak C. E. M. Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase Atherosclerosis 2011;216 (1):161-165 [PubMed]
• Kastelein John J. P., Duivenvoorden Raphaël, Deanfield John, de Groot Eric, Jukema J. Wouter, Kaski Juan-Carlos, Münzel Thomas, Taddei Stefano, Lehnert Valerie, Burgess Tracy, Kallend David, Lüscher Thomas F. Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation Current medical research and opinion 2011;27 (1):141-150 [PubMed]
• Rensing K. L., Reuwer A. Q., Arsenault B. J., von der Thüsen J. H., Hoekstra J. B. L., Kastelein J. J. P., Twickler Th B. Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing? Diabetes, obesity & metabolism 2011;13 (12):1073-1087 [PubMed]
• Broekhuizen Lysette N., van Wijk Diederik F., Vink Hans, Stalmach A., Crozier A., Hutten B. A., Kastelein John J. P., Hugenholtz Paul G., Koenig Wolfgang, Stroes Erik S. G. Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors British journal of nutrition 2011;106 (9):1416-1422 [PubMed]
• Ravandi Amir, Boekholdt S. Matthijs, Mallat Ziad, Talmud Philippa J., Kastelein John J. P., Wareham Nicholas J., Miller Elizabeth R., Benessiano Joelle, Tedgui Alain, Witztum Joseph L., Khaw Kay-Tee, Tsimikas Sotirios Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study Journal of lipid research 2011;52 (10):1829-1836 [PubMed]
• Preiss David, Seshasai Sreenivasa Rao Kondapally, Welsh Paul, Murphy Sabina A., Ho Jennifer E., Waters David D., Demicco David A., Barter Philip, Cannon Christopher P., Sabatine Marc S., Braunwald Eugene, Kastelein John J. P., de Lemos James A., Blazing Michael A., Pedersen Terje R., Tikkanen Matti J., Sattar Naveed, Ray Kausik K. Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy A Meta-analysis JAMA 2011;305 (24):2556-2564 [PubMed]
• Nolting Pernette R. W. de Sauvage, Kusters D. Meeike, Hutten Barbara A., Kastelein John J. P. Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease? Journal of lipid research 2011;52 (9):1755-1759 [PubMed]
• Reuwer Anne, van Eijk Marco, Houttuijn-Bloemendaal Felicia, van der Loos Chris, Claessen Nike, Teeling Peter, Kastelein J. J., Hamann Jörg, Goffin Vincent, von der Thüsen Jan, Twickler Marcel, Aten Jan The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis? Journal of endocrinology 2011;208 (2):107-117 [PubMed]
• Arsenault Benoit J., Boekholdt S. Matthijs, Kastelein John J. P. Varespladib: targeting the inflammatory face of atherosclerosis European heart journal 2011;32 (8):923-926 [PubMed]
• Taylor Allen J., Bots Michiel L., Kastelein John J. P. Vascular disease: Meta-regression of CIMT trials-data in, garbage out Nature reviews. Cardiology 2011;8 (3):128-130 [PubMed]

2010

• Jakulj Lily, Vissers Maud N., Tanck Michael W. T., Hutten Barbara A., Stellaard Frans, Kastelein John J. P., Dallinga-Thie Geesje M. ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis Journal of lipid research 2010;51 (10):3016-3023 [PubMed]
• Franssen Remco Abormalities in lipoprotein metabolism: from dysfunctionla HHDL to abnormal processing of triglyceride-rich lipoproteins 2010. 272p. ISBN 9789461080929. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Stroes E. S. G., Dallinga-Thie G. M.)
• Hovingh G. K., Bochem Andrea E., Kastelein John J. P. Apolipoprotein A-I mimetic peptides Current opinion in lipidology 2010;21 (6):481-486 [PubMed]
• Visser Maartje E., Kastelein John Jp, Stroes Erik Sg Apolipoprotein B synthesis inhibition: results from clinical trials Current opinion in lipidology 2010;21 (4):319-323 [PubMed]
• Motazacker Mohammad Mahdi, Kastelein John J., Kuivenhoven Jan Albert Are high-density lipoprotein genes and their products targets for therapy? Current opinion in lipidology 2010;21 (2):157-158 [PubMed]
• Charakida Marietta, Masi Stefano, Lüscher Thomas F., Kastelein John J. P., Deanfield John E. Assessment of atherosclerosis: the role of flow-mediated dilatation European heart journal 2010;31 (23):2854-U24 [PubMed]
• Jakulj Lily, Vissers Maud N., Groen Albert K., Hutten Barbara A., Lutjohann Dieter, Veltri Enrico P., Kastelein John J. P. Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial Journal of lipid research 2010;51 (4):755-762 [PubMed]
• Teslovich Tanya M., Musunuru Kiran, Smith Albert V., Edmondson Andrew C., Stylianou Ioannis M., Koseki Masahiro, Pirruccello James P., Ripatti Samuli, Chasman Daniel I., Willer Cristen J., Johansen Christopher T., Fouchier Sigrid W., Isaacs Aaron, Peloso Gina M., Barbalic Maja, Ricketts Sally L., Bis Joshua C., Aulchenko Yurii S., Thorleifsson Gudmar, Feitosa Mary F., Chambers John, Orho-Melander Marju, Melander Olle, Johnson Toby, Li Xiaohui, Guo Xiuqing, Li Mingyao, Shin Cho Yoon, Jin Go Min, Jin Kim Young, Lee Jong-Young, Park Taesung, Kim Kyunga, Sim Xueling, Twee-Hee Ong Rick, Croteau-Chonka Damien C., Lange Leslie A., Smith Joshua D., Song Kijoung, Hua Zhao Jing, Yuan Xin, Luan Jian'an, Lamina Claudia, Ziegler Andreas, Zhang Weihua, Zee Robert Y. L., Wright Alan F., Witteman Jacqueline C. M., Wilson James F., Willemsen Gonneke, Wichmann H.-Erich, Whitfield John B., Waterworth Dawn M., Wareham Nicholas J., Waeber Gérard, Vollenweider Peter, Voight Benjamin F., Vitart Veronique, Uitterlinden Andre G., Uda Manuela, Tuomilehto Jaakko, Thompson John R., Tanaka Toshiko, Surakka Ida, Stringham Heather M., Spector Tim D., Soranzo Nicole, Smit Johannes H., Sinisalo Juha, Silander Kaisa, Sijbrands Eric J. G., Scuteri Angelo, Scott James, Schlessinger David, Sanna Serena, Salomaa Veikko, Saharinen Juha, Sabatti Chiara, Ruokonen Aimo, Rudan Igor, Rose Lynda M., Roberts Robert, Rieder Mark, Psaty Bruce M., Pramstaller Peter P., Pichler Irene, Perola Markus, Penninx Brenda W. J. H., Pedersen Nancy L., Pattaro Cristian, Parker Alex N., Pare Guillaume, Oostra Ben A., O'Donnell Christopher J., Nieminen Markku S., Nickerson Deborah A., Montgomery Grant W., Meitinger Thomas, McPherson Ruth, McCarthy Mark I., McArdle Wendy, Masson David, Martin Nicholas G., Marroni Fabio, Mangino Massimo, Magnusson Patrik K. E., Lucas Gavin, Luben Robert, Loos Ruth J. F., Lokki Marja-Liisa, Lettre Guillaume, Langenberg Claudia, Launer Lenore J., Lakatta Edward G., Laaksonen Reijo, Kyvik Kirsten O., Kronenberg Florian, König Inke R., Khaw Kay-Tee, Kaprio Jaakko, Kaplan Lee M., Johansson Asa, Jarvelin Marjo-Riitta, Janssens A. Cecile J. W., Ingelsson Erik, Igl Wilmar, Hovingh G. Kees, Hottenga Jouke-Jan, Hofman Albert, Hicks Andrew A., Hengstenberg Christian, Heid Iris M., Hayward Caroline, Havulinna Aki S., Hastie Nicholas D., Harris Tamara B., Haritunians Talin, Hall Alistair S., Gyllensten Ulf, Guiducci Candace, Groop Leif C., Gonzalez Elena, Gieger Christian, Freimer Nelson B., Ferrucci Luigi, Erdmann Jeanette, Elliott Paul, Ejebe Kenechi G., Döring Angela, Dominiczak Anna F., Demissie Serkalem, Deloukas Panagiotis, de Geus Eco J. C., de Faire Ulf, Crawford Gabriel, Collins Francis S., Chen Yii-der I., Caulfield Mark J., Campbell Harry, Burtt Noel P., Bonnycastle Lori L., Boomsma Dorret I., Boekholdt S. Matthijs, Bergman Richard N., Barroso Inês, Bandinelli Stefania, Ballantyne Christie M., Assimes Themistocles L., Quertermous Thomas, Altshuler David, Seielstad Mark, Wong Tien Y., Tai E.-Shyong, Feranil Alan B., Kuzawa Christopher W., Adair Linda S., Taylor Herman A., Borecki Ingrid B., Gabriel Stacey B., Wilson James G., Holm Hilma, Thorsteinsdottir Unnur, Gudnason Vilmundur, Krauss Ronald M., Mohlke Karen L., Ordovas Jose M., Munroe Patricia B., Kooner Jaspal S., Tall Alan R., Hegele Robert A., Kastelein John J. P., Schadt Eric E., Rotter Jerome I., Boerwinkle Eric, Strachan David P., Mooser Vincent, Stefansson Kari, Reilly Muredach P., Samani Nilesh J., Schunkert Heribert, Cupples L. Adrienne, Sandhu Manjinder S., Ridker Paul M., Rader Daniel J., van Duijn Cornelia M., Peltonen Leena, Abecasis Gonçalo R., Boehnke Michael, Kathiresan Sekar Biological, clinical and population relevance of 95 loci for blood lipids Nature 2010;466 (7307):707-713 [PubMed]
• Holme I., Fayyad R., Faergeman O., Kastelein J. J. P., Olsson A. G., Tikkanen M. J., Larsen M. L., Lindahl C., Holdaas H., Pedersen T. R. Cardiovascular outcomes and their relationships to lipoprotein components in patients with and without chronic kidney disease: results from the IDEAL trial Journal of internal medicine 2010;267 (6):567-575 [PubMed]
• Vergeer Menno, Zhou Rong, Bots Michiel L., Duivenvoorden Raphaël, Koglin Joerg, Akdim Fatima, Mitchel Yale B., Huijgen Roeland, Sapre Aditi, de Groot Eric, Sijbrands Eric J. G., Pasternak Richard C., Gagné Claude, Marais A. David, Ballantyne Christie M., Isaacsohn Jonathan L., Stalenhoef Anton F. H., Kastelein John J. P. Carotid Atherosclerosis Progression in Familial Hypercholesterolemia Patients A Pooled Analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE Studies Circulation. Cardiovascular imaging 2010;3 (4):398-U70 [PubMed]
• Vergeer Menno, Brunham Liam R., Koetsveld Joris, Kruit Janine K., Verchere C. Bruce, Kastelein John J. P., Hayden Michael R., Stroes Erik S. G. Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction Diabetes care 2010;33 (4):869-874 [PubMed]
• van Wijk Diederik F., van Leuven Sander I., Sandhu Manjinder S., Tanck Michael W., Hutten Barbara A., Wareham Nicholas J., Kastelein John J. P., Stroes Erik S. G., Khaw Kay-Tee, Boekholdt S. Matthijs Chemokine Ligand 2 Genetic Variants, Serum Monocyte Chemoattractant Protein-1 Levels, and the Risk of Coronary Artery Disease Arteriosclerosis, thrombosis, and vascular biology 2010;30 (7):1460-U466 [PubMed]
• Franssen Remco, Young Stephen G., Peelman Frank, Hertecant Jozef, Sierts Jeroen A., Schimmel Alinda W. M., Bensadoun André, Kastelein John J. P., Fong Loren, Dallinga-Thie Geesje M., Beigneux Anne P. Chylomicronemia With Low Postheparin Lipoprotein Lipase Levels in the Setting of GPIHBP1 Defects Circulation. Cardiovascular genetics 2010;3 (2):169-178 [PubMed]
• Huijgen Roeland, Abbink Evertine J., Bruckert Eric, Stalenhoef Anton F. H., Imholz Ben P. M., Durrington Paul N., Trip M. D., Eriksson Mats, Visseren Frank L. J., Schaefer Juergen R., Kastelein John J. P. Colesevelam Added to Combination Therapy With a Statin and Ezetimibe in Patients With Familial Hypercholesterolemia: A 12-Week, Multicenter, Randomized, Double-Blind, Controlled Trial Clinical therapeutics 2010;32 (4):615-625 [PubMed]
• Arsenault Benoit J., Lemieux Isabelle, Després Jean-Pierre, Wareham Nicholas J., Stroes Erik S. G., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Comparison between Gradient Gel Electrophoresis and Nuclear Magnetic Resonance Spectroscopy in Estimating Coronary Heart Disease Risk Associated with LDL and HDL Particle Size Clinical chemistry 2010;56 (5):789-798 [PubMed]
• Pedersen Terje R., Cater Nilo B., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Tikkanen Matti J., Holme Ingar, Larsen Mogens Lytken, Lindahl Christina, Szarek Michael Comparison of atorvastatin 80 mg/day versus simvastatin 20 to 40 mg/day on frequency of cardiovascular events late (five years) after acute myocardial infarction (from the Incremental Decrease in End Points through Aggressive Lipid Lowering [IDEAL] trial) American journal of cardiology 2010;106 (3):354-359 [PubMed]
• Dogan Soner, Duivenvoorden Raphaël, Grobbee E. Diederick, Kastelein John J. P., Shear Charles L., Evans Gregory W., Visseren Frank L., Bots Michiel L. Completeness of Carotid Intima Media Thickness Measurements Depends on Body Composition: The RADIANCE 1 and 2 trials Journal of atherosclerosis and thrombosis 2010;17 (5):526-535 [PubMed]
• Boekholdt S. Matthijs, Kastelein John J. P. C-reactive protein and cardiovascular risk: more fuel to the fire Lancet 2010;375 (9709):95-96 [PubMed]
• Bisoendial Radjesh J., Boekholdt S. Matthijs, Vergeer Menno, Stroes Erik S. G., Kastelein John J. P. C-reactive protein is a mediator of cardiovascular disease European heart journal 2010;31 (17):2087-U1505 [PubMed]
• Boekholdt S. Matthijs, Kastelein John J. C-reactive protein measurement and cardiovascular disease Reply Lancet 2010;375 (9720):1077-1078
• van der Graaf Anouk, Vissers Maud N., Gaudet Daniel, Brisson Diane, Sivapalaratnam Suthesh, Roseboom Tessa J., Jansen Angelique C. M., Kastelein John J. P., Hutten Barbara A. Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring Arteriosclerosis, thrombosis, and vascular biology 2010;30 (12):2673-U623 [PubMed]
• Visser Maartje E., Akdim Fatima, Tribble Diane L., Nederveen Aart J., Kwoh T. Jesse, Kastelein John J. P., Trip Mieke D., Stroes Erik S. G. Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia Journal of lipid research 2010;51 (5):1057-1062 [PubMed]
• Akdim Fatima, Visser Maartje E., Tribble Diane L., Baker Brenda F., Stroes Erik S. G., Yu Rosie, Flaim Joann D., Su John, Stein Evan A., Kastelein John J. P. Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia American journal of cardiology 2010;105 (10):1413-1419 [PubMed]
• Akdim Fatima, Stroes Erik S. G., Sijbrands Eric J. G., Tribble Diane L., Trip Mieke D., Jukema J. Wouter, Flaim Joann D., Su John, Yu Rosie, Baker Brenda F., Wedel Mark K., Kastelein John J. P. Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy Journal of the American College of Cardiology 2010;55 (15):1611-1618 [PubMed]
• Avis Hans J., Hutten Barbara A., Gagné Claude, Langslet Gisle, McCrindle Brian W., Wiegman Albert, Hsia Judith, Kastelein John J. P., Stein Evan A. Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia Journal of the American College of Cardiology 2010;55 (11):1121-1126 [PubMed]
• Duivenvoorden Raphaël, VanBavel Ed, de Groot Eric, Stroes Erik S. G., Disselhorst Jonathan A., Hutten Barbara A., Laméris Johan S., Kastelein John J. P., Nederveen Aart J. Endothelial shear stress: a critical determinant of arterial remodeling and arterial stiffness in humans--a carotid 3.0-T MRI study Circulation. Cardiovascular imaging 2010;3 (5):578-585 [PubMed]
• Pijlman A. H., Huijgen R., Verhagen S. N., Imholz B. P. M., Liem A. H., Kastelein J. J. P., Abbink E. J., Stalenhoef A. F. H., Visseren F. L. J. Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: A large cross-sectional study in The Netherlands Atherosclerosis 2010;209 (1):189-194 [PubMed]
• Jakulj Lily, Vissers Maud N., van Roomen Cindy P., van der Veen Jelske N., Vrins Carlos L. J., Kunne Cindy, Stellaard Frans, Kastelein John J. P., Groen Albert K. Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice FEBS letters 2010;584 (16):3625-3628 [PubMed]
• van der Graaf Anouk Familial hypercholesterolemia. Cardiovascular disease prevention from childhood into adolescence 2010. 164p. ISBN 9789090255767. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Wijburg F. A.; Co-supervisors: Vissers M. N., Hutten B. A.)
• Sivapalaratnam Suthesh, Boekholdt S. Matthijs, Trip Mieke D., Sandhu Manjinder S., Luben Robert, Kastelein John J. P., Wareham Nicholas J., Khaw Kay-Tee Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study Heart (British Cardiac Society) 2010;96 (24):1985-1989 [PubMed]
• Huijgen Roeland, Kindt Iris, Fouchier Sigrid W., Defesche Joep C., Hutten Barbara A., Kastelein John J. P., Vissers Maud N. Functionality of Sequence Variants in the Genes Coding for the Low-Density Lipoprotein Receptor and Apolipoprotein B in Individuals with Inherited Hypercholesterolemia Human mutation 2010;31 (6):752-760 [PubMed]
• Vergeer Menno, Boekholdt S. Matthijs, Sandhu Manjinder S., Ricketts Sally L., Wareham Nicholas J., Brown Morris J., de Faire Ulf, Leander Karin, Gigante Bruna, Kavousi Maryam, Hofman Albert, Uitterlinden Andre G., van Duijn Cornelia M., Witteman Jacqueline C. M., Jukema J. Wouter, Schadt Eric E., van der Schoot Ellen, Kastelein John J. P., Khaw Kay-Tee, Dullaart Robin P. F., van Tol Arie, Trip Mieke D., Dallinga-Thie Geesje M. Genetic Variation at the Phospholipid Transfer Protein Locus Affects Its Activity and High-Density Lipoprotein Size and Is a Novel Marker of Cardiovascular Disease Susceptibility Circulation 2010;122 (5):470-U66 [PubMed]
• Ridker Paul M., Genest Jacques, Boekholdt S. Matthijs, Libby Peter, Gotto Antonio M., Nordestgaard Børge G., Mora Samia, Macfadyen Jean G., Glynn Robert J., Kastelein John Jp HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial Lancet 2010;376 (9738):333-339 [PubMed]
• Ridker Paul M., Genest Jacques, Kastelein John J. P. HDL cholesterol and residual risk of first cardiovascular events - Authors' reply Lancet 2010;376 (9754):1738-1739 [PubMed]
• Geenen M. M., Bakker P. J. M., Kremer L. C. M., Kastelein J. J. P., van Leeuwen F. E. Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy Pediatric blood & cancer 2010;55 (4):690-697 [PubMed]
• Vergeer Menno, Cohn Danny M., Boekholdt S. Matthijs, Sandhu Manjinder S., Prins Hester M., Ricketts Sally L., Wareham Nicholas J., Kastelein John J. P., Khaw Kay-Tee, Kamphuisen Pieter W., Dallinga-Thie Geesje M. Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT Atherosclerosis 2010;211 (2):558-564 [PubMed]
• Akdim Fatima LDL cholesterol lowering beyond statins 2010. 166p. ISBN 9789085599555. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Stroes E. S. G.)
• Arsenault Benoit J., Després Jean-Pierre, Stroes Erik S. G., Wareham Nicholas J., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Lipid assessment, metabolic syndrome and coronary heart disease risk European journal of clinical investigation 2010;40 (12):1081-1093 [PubMed]
• Sivapalaratnam S., van Loendersloot L. L., Hutten B. A., Kastelein J. J. P., Trip M. D., de Groot E. Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness Atherosclerosis 2010;212 (2):571-574 [PubMed]
• Rana Jamal S., Visser Maartje E., Arsenault Benoit J., Després Jean-Pierre, Stroes Erik S. G., Kastelein John J. P., Wareham Nicholas J., Boekholdt S. Matthijs, Khaw Kay-Tee Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study International journal of cardiology 2010;143 (3):399-404 [PubMed]
• van Leuven Sander I., van Wijk Diederik F., Volger Oscar L., de Vries Jean-Paul P. M., van der Loos Chris M., de Kleijn Dominique V. P., Horrevoets Anton J. G., Tak Paul P., van der Wal Allard C., de Boer Onno J., Pasterkamp Gerard, Hayden Michael R., Kastelein John J. P., Stroes Erik S. Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis Atherosclerosis 2010;211 (1):231-236 [PubMed]
• Duivenvoorden Raphaël, Vergeer Menno, Kastelein John J. P. Niacin Compared with Ezetimibe New England journal of medicine 2010;362 (11):1046-1047 [PubMed]
• Tsimikas Sotirios, Mallat Ziad, Talmud Philippa J., Kastelein John J. P., Wareham Nicholas J., Sandhu Manjinder S., Miller Elizabeth R., Benessiano Joelle, Tedgui Alain, Witztum Joseph L., Khaw Kay-Tee, Boekholdt S. Matthijs Oxidation-Specific Biomarkers, Lipoprotein(a), and Risk of Fatal and Nonfatal Coronary Events Journal of the American College of Cardiology 2010;56 (12):946-955 [PubMed]
• Arsenault Benoit J., Rana Jamal S., Lemieux Isabelle, Després Jean-Pierre, Wareham Nicholas J., Kastelein John J. P., Boekholdt S. Matthijs, Khaw Kay-Tee Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study Atherosclerosis 2010;209 (1):261-265 [PubMed]
• Arsenault B. J., Rana J. S., Lemieux I., Després J.-P., Kastelein J. J. P., Boekholdt S. M., Wareham N. J., Khaw K.-T. Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women International journal of obesity (2005) 2010;34 (2):340-347 [PubMed]
• Avis H. J., Scheffer H. J., Kastelein J. J. P., Dallinga-Thie G. M., Wijburg F. A. Pink-creamy whole blood in a 3-month-old infant with a homozygous deletion in the lipoprotein lipase gene Clinical genetics 2010;77 (5):430-433 [PubMed]
• Holleboom A. G., Kuivenhoven J. A., Vergeer M., Hovingh G. K., van Miert J. N., Wareham N. J., Kastelein J. J. P., Khaw K.-T., Boekholdt S. M. Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study Journal of lipid research 2010;51 (2):416-421 [PubMed]
• Arsenault Benoit J., Barter Philip, Demicco David A., Bao Weihang, Preston Gregory M., LaRosa John C., Grundy Scott M., Deedwania Prakash, Greten Heiner, Wenger Nanette K., Shepherd James, Waters David D., Kastelein John J. P. Prediction of Cardiovascular Events in Statin-Treated Stable Coronary Patients by Lipid and Nonlipid Biomarkers Journal of the American College of Cardiology 2010;57 (1):63-69 [PubMed]
• Reuwer Anne Q., Reuwer Paul J. H. M., van der Post Joris A., Cramer Maarten J., Kastelein John J. P., Twickler Marcel Th B. Prolactin fragmentation by trophoblastic matrix metalloproteinases as a possible contributor to peripartum cardiomyopathy and pre-eclampsia Medical hypotheses 2010;74 (2):348-352 [PubMed]
• Ridker Paul M., Macfadyen Jean G., Nordestgaard Børge G., Koenig Wolfgang, Kastelein John J. P., Genest Jacques, Glynn Robert J. Rosuvastatin for Primary Prevention Among Individuals With Elevated High-Sensitivity C-Reactive Protein and 5% to 10% and 10% to 20% 10-Year Risk Implications of the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial for "Intermediate Risk" Circulation. Cardiovascular quality and outcomes 2010;3 (5):447-452 [PubMed]
• Sofat Reecha, Hingorani Aroon D., Smeeth Liam, Humphries Steve E., Talmud Philippa J., Cooper Jackie, Shah Tina, Sandhu Manjinder S., Ricketts Sally L., Boekholdt S. Matthijs, Wareham Nicholas, Khaw Kay Tee, Kumari Meena, Kivimaki Mika, Marmot Michael, Asselbergs Folkert W., van der Harst Pim, Dullaart Robin P. F., Navis Gerjan, van Veldhuisen Dirk J., van Gilst Wiek H., Thompson John F., McCaskie Pamela, Palmer Lyle J., Arca Marcello, Quagliarini Fabiana, Gaudio Carlo, Cambien François, Nicaud Viviane, Poirer Odette, Gudnason Vilmundur, Isaacs Aaron, Witteman Jacqueline C. M., van Duijn Cornelia M., Pencina Michael, Vasan Ramachandran S., D'Agostino Ralph B., Ordovas Jose, Li Tricia Y., Kakko Sakari, Kauma Heikki, Savolainen Markku J., Kesäniemi Y. Antero, Sandhofer Anton, Paulweber Bernhard, Sorli Jose V., Goto Akimoto, Yokoyama Shinji, Okumura Kenji, Horne Benjamin D., Packard Chris, Freeman Dilys, Ford Ian, Sattar Naveed, McCormack Valerie, Lawlor Debbie A., Ebrahim Shah, Smith George Davey, Kastelein John J. P., Deanfield John, Casas Juan P. Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms Circulation 2010;121 (1):52-62 [PubMed]
• Bisoendial Radjesh J., Stroes Erik S. G., Kastelein John J. P., Tak Paul Peter Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins Nature reviews. Rheumatology 2010;6 (3):157-164 [PubMed]
• Vergeer Menno, Holleboom Adriaan G., Kastelein John J. P., Kuivenhoven Jan Albert The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis? Journal of lipid research 2010;51 (8):2058-2073 [PubMed]
• Arsenault Benoit J., Lemieux Isabelle, Després Jean-Pierre, Wareham Nicholas J., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk Prospective Population Study CMAJ 2010;182 (13):1427-1432 [PubMed]
• Dallinga-Thie Geesje M., Franssen Remco, Mooij Hans L., Visser Maartje E., Hassing H. Carlijne, Peelman Frank, Kastelein John J. P., Péterfy Miklós, Nieuwdorp Max The metabolism of triglyceride-rich lipoproteins revisited: New players, new insight Atherosclerosis 2010;211 (1):1-8 [PubMed]
• Oosterveer Daniëlla M., Versmissen Jorie, Yazdanpanah Mojgan, Defesche Joep C., Kastelein John J. P., Sijbrands Eric J. G. The risk of tendon xanthomas in familial hypercholesterolaemia is influenced by variation in genes of the reverse cholesterol transport pathway and the low-density lipoprotein oxidation pathway European heart journal 2010;31 (8):1007-1012 [PubMed]
• Kusters D. Meeike, Vissers Maud N., Wiegman Albert, Kastelein John Jp, Hutten Barbara A. Treatment of dyslipidaemia in childhood Expert opinion on pharmacotherapy 2010;11 (5):739-753 [PubMed]
• Sarwar Nadeem, Sandhu Manjinder S., Ricketts Sally L., Butterworth Adam S., Di Angelantonio Emanuele, Boekholdt S. Matthijs, Ouwehand Willem, Watkins Hugh, Samani Nilesh J., Saleheen Danish, Lawlor Debbie, Reilly Muredach P., Hingorani Aroon D., Talmud Philippa J., Danesh John, Braund P. S., Hall A. S., Samani N. J., Thompson J., März W., Ouwehand W., Sivapalaratnam S., Soranzo N., Trip M., Lawlor D. A., Casas J. P., Ebrahim S., Arsenault B. J., Khaw K. T., Ricketts S. L., Sandhu M. S., Wareham N. J., Grallert H., Illig T., Humphries S. E., Talmud Talmud, Rader D. J., He J., Reilly M. P., Clarke R., Hamsten A., Hopewell J. C., Watkins H., Saleheen D., Frossard P., Deloukas P., Danesh J., Ye S., Simpson I. A., Kastelein J. J. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies Lancet 2010;375 (9726):1634-1639 [PubMed]
• Huijgen Roeland, Kindt Iris, Verhoeven Sjoerd B. J., Sijbrands Eric J. G., Vissers Maud N., Kastelein John J. P., Hutten Barbara A. Two Years after Molecular Diagnosis of Familial Hypercholesterolemia: Majority on Cholesterol-Lowering Treatment but a Minority Reaches Treatment Goal PLoS ONE 2010;5 (2):e9220 [PubMed]
• Dogan Soner, Duivenvoorden Raphaël, Grobbee Diederick E., Kastelein John J. P., Shear Charles L., Evans Greg W., Visseren Frank L., Bots Michiel L. Ultrasound protocols to measure carotid intima-media thickness in trials; comparison of reproducibility, rate of progression, and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia Annals of medicine 2010;42 (6):447-464 [PubMed]

2009

• Oosterveer Daniëlla M., Versmissen Jorie, Yazdanpanah Mojgan, van der Net Jeroen B., Defesche Joep C., Kastelein John J. P., Sijbrands Eric J. G. 5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia Atherosclerosis 2009;206 (1):223-227 [PubMed]
• Mingozzi Federico, Meulenberg Janneke J., Hui Daniel J., Basner-Tschakarjan Etiena, Hasbrouck Nicole C., Edmonson Shyrie A., Hutnick Natalie A., Betts Michael R., Kastelein John J., Stroes Erik S., High Katherine A. AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells Blood 2009;114 (10):2077-2086 [PubMed]
• Koeijvoets Kristel C. M. C., van der Net Jeroen B., Dallinga-Thie Geesje M., Steyerberg Ewout W., Mensink Ronald P., Kastelein John J. P., Sijbrands Eric J. G., Plat Jogchum ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia Atherosclerosis 2009;204 (2):453-458 [PubMed]
• Meuwese Marijn C., de Groot Eric, Duivenvoorden Raphaël, Trip Mieke D., Ose Leiv, Maritz Frans J., Basart Dick C. G., Kastelein John J. P., Habib Rafik, Davidson Michael H., Zwinderman Aeilko H., Schwocho Lee R., Stein Evan A. ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia The CAPTIVATE Randomized Trial JAMA 2009;301 (11):1131-1139 [PubMed]
• Holme Ingar, Szarek Michael, Cater Nilo B., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Tikkanen Matti J., Larsen Mogens Lytken, Lindahl Christina, Pedersen Terje R. Adherence-adjusted efficacy with intensive versus standard statin therapy in patients with acute myocardial infarction in the IDEAL study European journal of cardiovascular prevention and rehabilitation 2009;16 (3):315-320 [PubMed]
• Hassing H. C., Twickler Th B., Kastelein J. J. P., Cramer M. J. M., Cassee F. R. Air pollution as noxious environmental factor in the development of cardiovascular disease Netherlands journal of medicine 2009;67 (4):116-121 [PubMed]
• van Leuven S. I., Birjmohun R. S., Franssen R., Bisoendial R. J., de Kort H., Levels J. H. M., Basser R. L., Meijers J. C. M., Kuivenhoven J. A., Kastelein J. J., Stroes E. S. ApoAI-phosphatidylcholine infusion neutralizes the atherothrombotic effects of C-reactive protein in humans Journal of thrombosis and haemostasis 2009;7 (2):347-354 [PubMed]
• Vaessen Stefan F. C. Apolipoproteins A-I and A-V as gene therapeutic targets to intervene in lipid metabolism 2009. 188p. ISBN 9789090245222. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Kuivenhoven J. A., Schaap F. G.)
• van der Net Jeroen B., Versmissen Jorie, Oosterveer Daniëlla M., Defesche Joep C., Yazdanpanah Mojgan, Aouizerat Bradley E., Steyerberg Ewout W., Malloy Mary J., Pullinger Clive R., Kane John P., Kastelein John J. P., Sijbrands Eric J. G. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia Atherosclerosis 2009;203 (2):472-478 [PubMed]
• Glynn Robert J., Danielson Eleanor, Fonseca Francisco A. H., Genest Jacques, Gotto Antonio M., Kastelein John J. P., Koenig Wolfgang, Libby Peter, Lorenzatti Alberto J., Macfadyen Jean G., Nordestgaard Børge G., Shepherd James, Willerson James T., Ridker Paul M. A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism New England journal of medicine 2009;360 (18):1851-1861 [PubMed]
• Arsenault Benoit J., Rana Jamal S., Stroes Erik S. G., Després Jean-Pierre, Shah Prediman K., Kastelein John J. P., Wareham Nicholas J., Boekholdt S. Matthijs, Khaw Kay-Tee Beyond Low-Density Lipoprotein Cholesterol Respective Contributions of Non-High-Density Lipoprotein Cholesterol Levels, Triglycerides, and the Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio to Coronary Heart Disease Risk in Apparently Healthy Men and Women Journal of the American College of Cardiology 2009;55 (1):35-41 [PubMed]
• Birjmohun Rakesh S., Vergeer Menno, Stroes Erik S. G., Sandhu Manjinder S., Ricketts Sally L., Tanck Michael W., Wareham Nicholas J., Jukema J. Wouter, Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Both Paraoxonase-1 Genotype and Activity Do Not Predict the Risk of Future Coronary Artery Disease; the EPIC-Norfolk Prospective Population Study PLoS ONE 2009;4 (8):e6809 [PubMed]
• Duivenvoorden Raphael, de Groot Eric, Kastelein John J. P. Carotid Atherosclerosis Progression and ACAT Inhibition Reply JAMA 2009;302 (3):256-257
• Beigneux Anne P., Franssen Remco, Bensadoun André, Gin Peter, Melford Kristan, Peter Jorge, Walzem Rosemary L., Weinstein Michael M., Davies Brandon S. J., Kuivenhoven Jan A., Kastelein John J. P., Fong Loren G., Dallinga-Thie Geesje M., Young Stephen G. Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase Arteriosclerosis, thrombosis, and vascular biology 2009;29 (6):956-U447 [PubMed]
• Franssen R., Vergeer M., Stroes E. S. G., Kastelein J. J. P. Combination statin-fibrate therapy: safety aspects Diabetes, obesity & metabolism 2009;11 (2):89-94 [PubMed]
• Strandberg Timo E., Holme Ingar, Faergeman Ole, Kastelein John J. P., Lindahl Christina, Larsen Mogens Lytken, Olsson Anders G., Pedersen Terje R., Tikkanen Matti J. Comparative Effect of Atorvastatin (80 mg) Versus Simvastatin (20 to 40 mg) in Preventing Hospitalizations for Heart Failure in Patients With Previous Myocardial Infarction American journal of cardiology 2009;103 (10):1381-1385 [PubMed]
• Tikkanen Matti J., Holme Ingar, Cater Nilo B., Szarek Michael, Faergeman Ole, Kastelein John J. P., Olsson Anders G., Larsen Mogens Lytken, Lindahl Christina, Pedersen Terje R., Bhatia Sonal Comparison of efficacy and safety of atorvastatin (80 mg) to simvastatin (20 to 40 mg) in patients aged <65 versus >or=65 years with coronary heart disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] study) American journal of cardiology 2009;103 (5):577-582 [PubMed]
• Duivenvoorden Raphaël, de Groot Eric, Afzali Hamid, Vanbavel Ed T., de Boer Onno J., Laméris Johan S., Fayad Zahi A., Stroes Erik S. G., Kastelein John J. P., Nederveen Aart J. Comparison of In Vivo Carotid 3.0-T Magnetic Resonance to B-Mode Ultrasound Imaging and Histology in a Porcine Model JACC. Cardiovascular imaging 2009;2 (6):744-750 [PubMed]
• Koeijvoets Kristel C. M. C., Mooijaart Simon P., Dallinga-Thie Geesje M., Defesche Joep C., Steyerberg Ewout W., Westendorp Rudi G. J., Kastelein John J. P., van Hagen P. Martin, Sijbrands Eric J. G. Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia European heart journal 2009;30 (5):618-623 [PubMed]
• Arsenault Benoit J., Boekholdt S. Matthijs, Kastelein John J. P., Després Jean-Pierre Comprehensive lipid profiling beyond LDLin: Morteza Naghavi, editors. Asymptomatic atherosclerosis; pathophysiology, detection & treatment. New York: Humana Press; 2009. p. 210-221
• Thompson John F., Hyde Craig L., Wood Linda S., Paciga Sara A., Hinds David A., Cox David R., Hovingh G. Kees, Kastelein John J. P. Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort Circulation. Cardiovascular genetics 2009;2 (2):173-U240 [PubMed]
• Holme Ingar, Strandberg Timo E., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Tikkanen Matti J., Larsen Mogens Lytken, Lindahl Christina, Pedersen Terje R. Congestive heart failure is associated with lipoprotein components in statin-treated patients with coronary heart disease Insights from the Incremental Decrease in End points Through Aggressive Lipid Lowering Trial (IDEAL) Atherosclerosis 2009;205 (2):522-527 [PubMed]
• Bisoendial Radjesh J., Birjmohun Rakesh S., Akdim Fatima, van 't Veer Cornelis, Spek C. Arnold, Hartman Daniel, de Groot Els R., Bankaitis-Davis Danute M., Kastelein John J. P., Stroes Erik S. G. C-Reactive Protein Elicits White Blood Cell Activation in Humans American journal of medicine 2009;122 (6):582.e1-582.e9 [PubMed]
• Stroes E. S. G., Kastelein J. J. P., Bénardeau A., Kuhlmann O., Blum D., Campos L. A., Clerc R. G., Niesor E. J. Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats British journal of pharmacology 2009;158 (7):1763-1770 [PubMed]
• Broekhuizen Lysette N., Mooij Hans L., Kastelein John J. P., Stroes Eric S. G., Vink Hans, Nieuwdorp Max Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease Current opinion in lipidology 2009;20 (1):57-62 [PubMed]
• Arsenault Benoit J., Lemieux Isabelle, Després Jean-Pierre, Gagnon Pascale, Wareham Nicholas J., Stroes Erik S. G., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study Atherosclerosis 2009;206 (1):276-281 [PubMed]
• van der Graaf A., Kastelein J. J. P., Wiegman A. Heterozygous familial hypercholesterolaemia in childhood: Cardiovascular risk prevention Journal of inherited metabolic disease 2009;32 (6):699-705 [PubMed]
• El Harchaoui Karim, Arsenault Benoit J., Franssen Remco, Després Jean-Pierre, Hovingh G. Kees, Stroes Erik S. G., Otvos James D., Wareham Nicholas J., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs High-Density Lipoprotein Particle Size and Concentration and Coronary Risk Annals of internal medicine 2009;150 (2):84-U43 [PubMed]
• van Zaane Bregje, Reuwer Anne Q., Büller Harry R., Kastelein John J. P., Gerdes Victor E. A., Twickler Marcel Th B. Hormones and Cardiovascular Disease: A Shift in Paradigm with Clinical Consequences? Seminars in thrombosis and hemostasis 2009;35 (5):478-487 [PubMed]
• van der Steeg Willem A. Improving cardiovascular disease prevention: from risk assessment to novel therapy 2009. 166p. ISBN 9789071382840. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. . J. . P.; Co-supervisors: Kuivenhoven J. A., Stroes E. S. G.)
• Sankatsing Raaj R., Wit Ferdinand W., Vogel Martin, de Groot Eric, Brinkman Kees, Rockstroh Juergen K., Kastelein John J. P., Stroes Erik S. G., Reiss Peter Increased carotid intima-media thickness in HIV patients treated with protease inhibitors as compared to non-nucleoside reverse transcriptase inhibitors Atherosclerosis 2009;202 (2):589-595 [PubMed]
• van Leuven Sander I. Inflammation and its echo in atherosclerosis 2009. 339p. ISBN 9789490122386. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Stroes E. S. G.)
• Rana J. S., Cote M., Després J.-P., Sandhu M. S., Talmud P. J., Ninio E., Wareham N. J., Kastelein J. J. P., Zwinderman A. H., Khaw K.-T., Boekholdt S. M. Inflammatory biomarkers and the prediction of coronary events among people at intermediate risk: the EPIC-Norfolk prospective population study Heart (British Cardiac Society) 2009;95 (20):1682-1687 [PubMed]
• Duivenvoorden R., de Groot E., Elsen B. M., Laméris J. S., van der Geest R. J., Stroes E. S., Kastelein J. J. P., Nederveen A. J. In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging Circulation. Cardiovascular imaging 2009;2 (3):235-242 [PubMed]
• Rensing Katrijn L., Kastelein John J. P., Twickler Marcel Is Insulin the Preferred Compound in Lowering Glucose Levels in Patients After a Myocardial Infarction? Archives of internal medicine 2009;169 (17):1636-1637 [PubMed]
• van Wijk Diederik F., Stroes Erik S. G., Kastelein John J. P. Lipid measures and cardiovascular disease prediction Disease markers 2009;26 (5-6):209-216 [PubMed]
• de Fost M., Langeveld M., Franssen R., Hutten B. A., Groener J. E. M., de Groot E., Mannens M. M., Bikker H., Aerts J. M. F. G., Kastelein J. J. P., Hollak C. E. M. Low HDL cholesterol levels in type I Gaucher disease do not lead to an increased risk of cardiovascular disease Atherosclerosis 2009;204 (1):267-272 [PubMed]
• Franssen Remco, Sankatsing Raaj R., Hassink Elly, Hutten Barbara, Ackermans Mariette T., Brinkman Kees, Oesterholt René, Arenas-Pinto Alejandro, Storfer Stephen P., Kastelein John J., Sauerwein Hans P., Reiss Peter, Stroes Erik S. Nevirapine Increases High-Density Lipoprotein Cholesterol Concentration by Stimulation of Apolipoprotein A-I Production Arteriosclerosis, thrombosis, and vascular biology 2009;29 (9):1336-1341 [PubMed]
• Ridker Paul M., Macfadyen Jean G., Fonseca Francisco A. H., Genest Jacques, Gotto Antonio M., Kastelein John J. P., Koenig Wolfgang, Libby Peter, Lorenzatti Alberto J., Nordestgaard Børge G., Shepherd James, Willerson James T., Glynn Robert J. Number Needed to Treat With Rosuvastatin to Prevent First Cardiovascular Events and Death Among Men and Women With Low Low-Density Lipoprotein Cholesterol and Elevated High-Sensitivity C-Reactive Protein Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) Circulation. Cardiovascular quality and outcomes 2009;2 (6):616-623 [PubMed]
• Semb Anne G., Ueland Thor, Aukrust Pål, Wareham Nicholas J., Luben Robert, Gullestad Lars, Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003 Arteriosclerosis, thrombosis, and vascular biology 2009;29 (6):975-980 [PubMed]
• Regieli Jakub J., Jukema J. Wouter, Doevendans Pieter A., Zwinderman Aeilko H., Kastelein John J., Grobbee Diederick E., van der Graaf Yolanda Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention Journal of the American College of Cardiology 2009;54 (14):1238-1245 [PubMed]
• Meuwese Marijn C., Mooij Hans L., Nieuwdorp Max, van Lith Bart, Marck Roos, Vink Hans, Kastelein John J. P., Stroes Erik S. G. Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia Journal of lipid research 2009;50 (1):148-153 [PubMed]
• Hassing Carlijne, Twickler Marcel, Brunekreef Bert, Cassee Flemming, Doevendans Pieter, Kastelein John, Cramer Maarten Jan Particulate air pollution, coronary heart disease and individual risk assessment: a general overview European journal of cardiovascular prevention and rehabilitation 2009;16 (1):10-15 [PubMed]
• Faergeman Ole, Holme Ingar, Fayyad Rana, Bhatia Sonal, Grundy Scott M., Kastelein John J. P., LaRosa John C., Larsen Mogens Lytken, Lindahl Christina, Olsson Anders G., Tikkanen Matti J., Waters David D., Pedersen Terje R. Plasma Triglycerides and Cardiovascular Events in the Treating to New Targets and Incremental Decrease in End-Points Through Aggressive Lipid Lowering Trials of Statins in Patients With Coronary Artery Disease American journal of cardiology 2009;104 (4):459-463 [PubMed]
• Regieli Jakub J., Jukema J. Wouter, Doevendans Pieter A., Zwinderman Aeilko H., van der Graaf Yolanda, Kastelein John J., Grobbee Diederick E. PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients Diabetes care 2009;32 (5):839-844 [PubMed]
• Avis Hans J., Hutten Barbara A., Twickler Marcel Th B., Kastelein John J. P., van der Post Joris A. M., Stalenhoef Anton F., Vissers Maud N. Pregnancy in women suffering from familial hypercholesterolemia: a harmful period for both mother and newborn? Current opinion in lipidology 2009;20 (6):484-490 [PubMed]
• Reuwer Anne Q., Nieuwland Rienk, Fernandez Isabelle, Goffin Vincent, van Tiel Claudia M., Schaap Marianne C. L., Berckmans René J., Kastelein John J. P., Twickler Marcel Th B. Prolactin does not affect human platelet aggregation or secretion Thrombosis and haemostasis 2009;101 (6):1119-1127 [PubMed]
• Reuwer Anne Q., Twickler Marcel Th B., Hutten Barbara A., Molema Frederique W., Wareham Nicholas J., Dallinga-Thie Geesje M., Bogorad Roman L., Goffin Vincent, Smink-Bol Mijke, Kastelein John J. P., Boekholdt S. Matthijs, Khaw Kay-Tee Prolactin Levels and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation. Cardiovascular genetics 2009;2 (4):389-U239 [PubMed]
• Harchaoui Karim El, Franssen Remco, Hovingh G. Kees, Bisoendial Radjesh J., Stellaard Frans, Kuipers Folkert, Kastelein John J. P., Kuivenhoven Jan Albert, Stroes Erik S. G., Groen Albert K. Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia Atherosclerosis 2009;207 (2):614-616 [PubMed]
• Ridker Paul M., Danielson Eleanor, Fonseca Francisco Ah, Genest Jacques, Gotto Antonio M., Kastelein John Jp, Koenig Wolfgang, Libby Peter, Lorenzatti Alberto J., Macfadyen Jean G., Nordestgaard Børge G., Shepherd James, Willerson James T., Glynn Robert J. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial Lancet 2009;373 (9670):1175-1182 [PubMed]
• Ridker Paul M., Danielson Eleanor, Fonseca Francisco A. H., Genest Jacques, Gotto Antonio M., Kastelein John J. P., Koenig Wolfgang, Libby Peter, Lorenzatti Alberto J., Macfadyen Jean G., Nordestgaard Borge G., Shepherd James, Willerson James T., Glynn Robert J. Reduction in C-Reactive Protein and Low-Density Lipoprotein Cholesterol and Cardiovascular Event Rates After Initiation of Rosuvastatin: A Prospective Study of the justification for the Use of Statins in Prevention: An Intervention, Trial Evaluating Rosuvastatin Trial Obstetrical & gynecological survey 2009;64 (9):596-597
• van Hoek M., van Tol A., van Vark-van der Zee L. C., Jansen H., Kastelein J. J. P., Sijbrands E. J. G., Dallinga-Thie G. M. Role of plasma adiponectin on the HDL-cholesterol raising effect of atorvastatin in patients with type 2 diabetes Current medical research and opinion 2009;25 (1):93-101 [PubMed]
• Stein Evan A., Stroes Erik S. G., Steiner George, Buckley Brendan M., Capponi Alessandro M., Burgess Tracy, Niesor Eric J., Kallend David, Kastelein John J. P. Safety and tolerability of dalcetrapib American journal of cardiology 2009;104 (1):82-91 [PubMed]
• Kastelein John J. P., Bots Michiel L. Statin therapy with ezetimibe or niacin in high-risk patients New England journal of medicine 2009;361 (22):2180-2183 [PubMed]
• Duivenvoorden Raphaël, de Groot Eric, Stroes Erik S. G., Kastelein John J. P. Surrogate markers in clinical trials-Challenges and opportunities Atherosclerosis 2009;206 (1):8-16 [PubMed]
• Wijbrandts C. A., van Leuven S. I., Boom H. D., Gerlag D. M., Stroes E. G. S., Kastelein J. J. P., Tak P. P. Sustained changes in lipid profile and macrophage migration inhibitory factor levels after anti-tumour necrosis factor therapy in rheumatoid arthritis Annals of the rheumatic diseases 2009;68 (8):1316-1321 [PubMed]
• Henneman Peter, van der Sman-de Beer Femke, Moghaddam Payman Hanifi, Huijts Petra, Stalenhoef Anton F. H., Kastelein John J. P., van Duijn Cornelia M., Havekes Louis M., Frants Rune R., van Dijk Ko Willems, Smelt Augustinus H. M. The expression of type III hyperlipoproteinemia: involvement of lipolysis genes European journal of human genetics 2009;17 (5):620-628 [PubMed]
• Strang Aart C., Hovingh G. Kees, Stroes Erik S. G., Kastelein John J. P. The genetics of high-density lipoprotein metabolism: clinical relevance for therapeutic approaches American journal of cardiology 2009;104 (10 Suppl):22E-31E [PubMed]
• El-Harchaoui Karim The puzzle of high-density lipoprotein in cardiovascular prevention 2009. 173p. ISBN 9789085596042. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Stroes E. S. G., Kuivenhoven J. A.)
• Avis Hans J., Vissers Maud N., Wijburg Frits A., Kastelein John J. P., Hutten Barbara A. The use of lipid-lowering drug therapy in children and adolescents CURRENT OPINION IN INVESTIGATIONAL DRUGS 2009;10 (3):224-231 [PubMed]
• Taylor Jennifer, Kastelein John J. P. "This Will Be About Making the Databases Large Enough so we Find the Few Diamonds That We Need" Circulation 2009;119 (14):F82-F84
• Tikkanen Matti J., Szarek Michael, Fayyad Rana, Holme Ingar, Cater Nilo B., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Larsen Mogens Lytken, Lindahl Christina, Pedersen Terje R. Total Cardiovascular Disease Burden: Comparing Intensive With Moderate Statin Therapy Insights From the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) Trial Journal of the American College of Cardiology 2009;54 (25):2353-2357 [PubMed]
• Harchaoui K. E. L., Visser M. E., Kastelein J. J. P., Stroes E. S., Dallinga-Thie G. M. Triglycerides and cardiovascular risk Current cardiology reviews 2009;5 (3):216-222 [PubMed]
• Nieuwdorp M., Meuwese M. C., Mooij H. L., van Lieshout M. H. P., Hayden A., Levi M. [=Marcel M.], Meijers J. C. M., Ince C., Kastelein J. J. P., Vink H., Stroes E. S. G. Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation Atherosclerosis 2009;202 (1):296-303 [PubMed]
• van der Net Jeroen B., Janssens A. Cecile J. W., Defesche Joep C., Kastelein John J. P., Sijbrands Eric J. G., Steyerberg Ewout W. Usefulness of Genetic Polymorphisms and Conventional Risk Factors to Predict Coronary Heart Disease in Patients With Familial Hypercholesterolemia American journal of cardiology 2009;103 (3):375-380 [PubMed]

2008

• Brunham Liam R., Kastelein John J. P., Hayden Michael R. ABCA1 Gene Mutations, HDL Cholesterol Levels, and Risk of Ischemic Heart Disease JAMA 2008;300 (17):1997-1998 [PubMed]
• Vergeer Menno, Kastelein John J. P. Anacetrapib: new hope for cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia Nature clinical practice. Cardiovascular medicine 2008;5 (6):302-303 [PubMed]
• Wright C. I., Scholten H. J., Schilder J. C. M., Elsen B. M., Hanselaar W., Kroner C. I., Draijer R., Kastelein J. J. P., Stok W., Karemaker J., de Groot E. Arterial stiffness, endothelial function and microcirculatory reactivity in healthy young males Clinical physiology and functional imaging 2008;28 (5):299-306 [PubMed]
• van der Graaf Anouk, Rodenburg Jessica, Vissers Maud N., Hutten Barbara A., Wiegman Albert, Trip Mieke D., Stroes Erik S. G., Wijburg Frits A., Otvos James D., Kastelein John J. P. Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia Journal of pediatrics 2008;152 (6):873-878 [PubMed]
• Sankatsing Raaj R. Atherosclerosis in the HIV and Non-HIV setting: detecting and modifying cardiovascular risk 2008. 191p. ISBN 9789071382673. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Reiss P.; Co-supervisor: Stroes E. S. G.)
• Regieli Jakub J., Jukema J. Wouter, Grobbee Diederick E., Kastelein John J. P., Kuivenhoven Jan Albert, Zwinderman Aeilko H., van der Graaf Yolanda, Bots Michiel L., Doevendans Pieter A. CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction European heart journal 2008;29 (22):2792-2799 [PubMed]
• Vergeer Menno, Bots Michiel L., van Leuven Sander I., Basart Dick C., Sijbrands Eric J., Evans Gregory W., Grobbee Diederick E., Visseren Frank L., Stalenhoef Anton F., Stroes Erik S., Kastelein John J. P. Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib and Off-Target Toxicity A Pooled Analysis of the Rating Atherosclerotic Disease Change by Imaging With a New CETP Inhibitor (RADIANCE) Trials Circulation 2008;118 (24):2515-2522 [PubMed]
• van der Net Jeroen B., Janssens A. Cecile J. W., Eijkemans Marinus J. C., Kastelein John J. P., Sijbrands Eric J. G., Steyerberg Ewout W. Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies European journal of human genetics 2008;16 (9):1111-1116 [PubMed]
• El Harchaoui Karim, Akdim Fatima, Stroes Erik S. G., Trip Mieke D., Kastelein John J. P. Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins American journal of cardiovascular drugs 2008;8 (4):233-242 [PubMed]
• Nissen Steven E., Nicholls Stephen J., Wolski Kathy, Rodes-Cabau Josep, Cannon Christopher P., Deanfield John E., Despres Jean-Pierre, Kastelein John J. P., Steinhubl Steven R., Kapadia Samir, Yasin Muhammad, Ruzyllo Witold, Gaudin Christophe, Job Bernard, Hu Bo, Bhatt Deepak L., Lincoff A. Michael, Tuzcu E. Murat Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease - The STRADIVARIUS randomized controlled trial JAMA 2008;299 (13):1547-1560 [PubMed]
• Birjmohun Rakesh S., Hovingh G. Kees, Stroes Erik S. G., Hofstra Jorit J., Dallinga-Thie Geesje M., Meijers Joost C. M., Kastelein John J. P., Levi Marcel Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema Clinical therapeutics 2008;30 (12):2314-2323 [PubMed]
• Dorfmeister B., Zeng W. W., Dichlberger A., Nilsson S. K., Schaap F. G., Hubacek J. A., Merkel M., Cooper J. A., Lookene A., Putt W., Whittall R., Lee P. J., Lins L., Delsaux N., Nierman M., Kuivenhoven J. A., Kastelein J. J. P., Vrablik M., Olivecrona G., Schneider W. J., Heeren J., Humphries S. E., Talmud P. J. Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding Arteriosclerosis, thrombosis, and vascular biology 2008;28 (10):1866-1871 [PubMed]
• van der Graaf Anouk, Cuffie-Jackson Cynthia, Vissers Maud N., Trip Mieke D., Gagné Claude, Shi Genming, Veltri Enrico, Avis Hans J., Kastelein John J. P. Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia Journal of the American College of Cardiology 2008;52 (17):1421-1429 [PubMed]
• Vissers Maud N., Trip Mieke D., Pritchard P. Haydn, Tam Patrick, Lukic Tatjana, de Sain-van der Velden Monique G., de Barse Martina, Kastelein John J. P. Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia European journal of clinical pharmacology 2008;64 (7):651-661 [PubMed]
• Versmissen Jorie, Oosterveer Daniëlla M., Yazdanpanah Mojgan, Defesche Joep C., Basart Dick C. G., Liem Anho H., Heeringa Jan, Witteman Jacqueline C., Lansberg Peter J., Kastelein John J. P., Sijbrands Eric J. G. Efficacy of statins in familial hypercholesterolaemia: a long term cohort study BMJ (Clinical research ed.) 2008;337:a2423 [PubMed]
• van der Graaf Anouk, Touchier Sigrid W., Vissers Maud N., Defesche Joep C., Wiegman Albert, Sankatsing Raaj R., Hutten Barbara A., Trip Mieke D., Kastelein John J. P. Familial defective apolipoprotein B and familial hypobetalipoproteinemia in one family: Two neutralizing mutations Annals of internal medicine 2008;148 (9):712-714 [PubMed]
• Huijgen Roeland, Vissers Maud N., Defesche Joep C., Lansberg Peter J., Kastelein John J. P., Hutten Barbara A. Familial hypercholesterolemia: current treatment and advances in management Expert review of cardiovascular therapy 2008;6 (4):567-581 [PubMed]
• van der Net Jeroen B., van Etten Jeroen, Yazdanpanah Mojgan, Dallinga-Thie Geesje M., Kastelein John J. P., Defesche Joep C., Koopmans Richard P., Steyerberg Ewout W., Sijbrands Eric J. G. Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia European heart journal 2008;29 (11):1370-1376 [PubMed]
• van der Net Jeroen B., Isaacs Aaron, Dallinga-Thie Geesje M., Kastelein John J. P., Defesche Joep C., Steyerberg Ewout W., Sijbrands Eric J. G. Haplotype of the angiotensinogen gene is associated with coronary heart disease in familial hypercholesterolemia Journal of hypertension 2008;26 (3):462-467 [PubMed]
• Birjmohun R. S. HDL on the crossroads of inflammation, coagulation and atherosclerosis 2008. 284p. ISBN 9789090902307. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Stroes E. S. G.)
• van Leuven Sander I., Stroes Erik S., Kastelein John J. P. High-density lipoprotein: A fall from grace? Annals of medicine 2008;40 (8):584-593 [PubMed]
• van der Steeg Wim A., Holme Ingar, Boekholdt S. Matthijs, Larsen Mogens Lytken, Lindahl Christina, Stroes Erik S. G., Tikkanen Matti J., Wareham Nicholas J., Faergeman Ole, Olsson Anders G., Pedersen Terje R., Khaw Kay-Tee, Kastelein John J. P. High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: Significance for cardiovascular risk - The IDEAL and EPIC-Norfolk studies Journal of the American College of Cardiology 2008;51 (6):634-642 [PubMed]
• van Acker Bernadette A. C., Botma Gert-Jan, Zwinderman Aeilko H., Kuivenhoven Jan Albert, Dallinga-Thie Geesje M., Sijbrands Eric J. G., Boer Jolanda M. A., Seidell Jacob C., Jukema J. Wouter, Kastelein John J. P., Jansen Hans, Verhoeven Adrie J. M. High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants Atherosclerosis 2008;200 (1):161-167 [PubMed]
• Boekholdt S. Matthijs, de Winter Robbert J., Kastelein John J. P. Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier? Circulation 2008;118 (11):1120-1122 [PubMed]
• Shah Sanjiv J., Waters David D., Barter Philip, Kastelein John J. P., Shepherd James, Wenger Nanette K., Demicco David A., Breazna Andrei, LaRosa John C. Intensive lipid-lowering with atorvastatin for secondary prevention in patients after coronary artery bypass surgery Journal of the American College of Cardiology 2008;51 (20):1938-1943 [PubMed]
• Shepherd James, Kastelein John P., Bittner Vera A., Carmena Rafael, Deedwania Prakash C., Breazna Andrei, Dobson Stephen, Wilson Daniel J., Zuckerman Andrea L., Wenger Nannette K. Intensive lipid lowering with atorvastatin in patients with coronary artery disease, diabetes, and chronic kidney disease Mayo Clinic proceedings. Mayo Clinic 2008;83 (8):870-879 [PubMed]
• Shepherd James, Kastelein John J. P., Bittner Vera, Deedwania Prakash, Breazna Andrei, Dobson Stephen, Wilson Daniel J., Zuckerman Andrea, Wenger Nanette K. Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease Journal of the American College of Cardiology 2008;51 (15):1448-1454 [PubMed]
• Stroes Erik S., Nierman Melchior C., Meulenberg Janneke J., Franssen Remco, Twisk Jaap, Henny C. Pieter, Maas Mario M., Zwinderman Aeilko H., Ross Colin, Aronica Eleonora, High Katherine A., Levi Marcel M., Hayden Michael R., Kastelein John J., Kuivenhoven Jan Albert Intramuscular Administration of AAV1-Lipoprotein Lipase(S447X) Lowers Triglycerides in Lipoprotein Lipase-Deficient Patients Arteriosclerosis, thrombosis, and vascular biology 2008;28 (12):2303-U264 [PubMed]
• Visser Maartje E., Jakulj Lily, Kastelein John J. P., Stroes Erik S. G. LDL-C-lowering therapy: current and future therapeutic targets Current cardiology reports 2008;10 (6):512-520 [PubMed]
• Kastelein John J. P., van der Steeg Wim A., Holme Ingar, Gaffney Michael, Cater Nilo B., Barter Philip, Deedwania Prakash, Olsson Anders G., Boekholdt S. Matthijs, Demicco David A., Szarek Michael, LaRosa John C., Pedersen Terje R., Grundy Scott M. Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment Circulation 2008;117 (23):3002-3009 [PubMed]
• Holme Ingar, Cater Nilo B., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Tikkanen Matti J., Larsen Mogens Lytken, Lindahl Christina, Pedersen Terje R. Lipoprotein predictors of cardiovascular events in statin-treated patients with coronary heart disease. insights from the incremental decrease in end-points through aggressive lipid-lowering trial (IDEAL) Annals of medicine 2008;40 (6):456-464 [PubMed]
• Bouhali Tarek, Brisson Diane, St-Pierre Julie, Tremblay Gerald, Perron Patrice, Laprise Catherine, Vohl Marie-Claude, Vissers Maud N., Hutten Barbara A., Després Jean-Pierre, Kastelein John J. P., Gaudet Daniel Low plasma adiponectin exacerbates the risk of premature coronary artery disease in familial hypercholesterolemia Atherosclerosis 2008;196 (1):262-269 [PubMed]
• de Groot Eric, van Leuven Sander I., Duivenvoorden Raphaël, Meuwese Marijn C., Akdim Fatima, Bots Michiel L., Kastelein John Jp Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis Nature clinical practice. Cardiovascular medicine 2008;5 (5):280-288 [PubMed]
• Nieuwdorp Max, Meuwese Marijn C., Mooij Hans L., Ince Can, Broekhuizen Lysette N., Kastelein John J. P., Stroes Erik S. G., Vink Hans Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability Journal of applied physiology (Bethesda, Md. 2008;104 (3):845-852 [PubMed]
• Homsma Sietske J. M., Huijgen Roeland, Middeldorp Saskia, Sijbrands Eric J. G., Kastelein John J. P. Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance European journal of human genetics 2008;16 (1):14-17 [PubMed]
• Homsma Sietske J. M., Huijgen Roeland, Middeldorp Saskia, Sijbrands Eric J. G., Kastelein John J. P. Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance [Corrigendum] European journal of human genetics 2008;16 (2):275 [PubMed]
• Meuwese Marijn C., Trip Mieke D., van Wissen Sanne, van Miert Jorarn N. I., Kastelein John J. P., Stroes Erik S. G. Myeloperoxidase levels are not associated with carotid atherosclerosis progression in patients with familial hypercholesterolemia Atherosclerosis 2008;197 (2):916-921 [PubMed]
• Franssen Remco, Monajemi Houshang, Stroes Erik S. G., Kastelein John J. P. Obesity and Dyslipidemia Endocrinology and metabolism clinics of North America 2008;37 (3):623-+ [PubMed]
• Nieuwdorp M., Vergeer M., Bisoendial R. J., Op 't Roodt J., Levels H., Birjmohun R. S., Kuivenhoven J. A., Basser R., Rabelink T. J., Kastelein J. J. P., Stroes E. S. G. Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus Diabetologia 2008;51 (6):1081-1084 [PubMed]
• van der Net Jeroen B., Oosterveer Daniëlla M., Versmissen Jorie, Defesche Joep C., Yazdanpanah Mojgan, Aouizerat Bradley E., Steyerberg Ewout W., Malloy Mary J., Pullinger Clive R., Kastelein John J. P., Kane John P., Sijbrands Eric J. G. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia European heart journal 2008;29 (18):2195-2201 [PubMed]
• Franssen Remco, Visser Maartje E., Kuivenhoven Jan Albert, Kastelein John J. P., Dallinga-Thie Geesje M., Stroes Erik S. G. Role of lipoprotein lipase in triglyceride metabolism: potential therapeutic target FUTURE LIPIDOLOGY 2008;3 (4):385-397
• Ridker Paul M., Danielson Eleanor, Fonseca Francisco A. H., Genest Jacques, Gotto Antonio M., Kastelein John J. P., Koenig Wolfgang, Libby Peter, Lorenzatti Alberto J., Macfadyen Jean G., Nordestgaard Børge G., Shepherd James, Willerson James T., Glynn Robert J., Ridker P. M., Fonseca F. A. H., Genest J., Gotto A. M., Koenig W., Libby P., Lorenzatti A. J., Nordestgaard B. G., Shepherd J., Willerson J. T., Danielson E., Glynn R. J., MacFadyen J. G., Mora S., Collins R., Bailey K., Gersh B., Lamas G., Smith S., Vaughan D., Mahaffey K., Brown P., Montgomery D., Wilson M., Wood F., Altamirano J., Boskis P., Colombo H., Cuneo C., Diaz M., Esper R., Trip M., Hoekstra J., Koch S., Lucas M., van de Beek M. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein New England journal of medicine 2008;359 (21):2195-2207 [PubMed]
• Sagoo Gurdeep S., Tatt Iain, Salanti Georgia, Butterworth Adam S., Sarwar Nadeem, van Maarle Merel, Jukema J. Wouter, Wiman Björn, Kastelein John J. P., Bennet Anna M., de Faire Ulf, Danesh John, Higgins Julian P. T. Seven Lipoprotein Lipase Gene Polymorphisms, Lipid Fractions, and Coronary Disease: A HuGE Association Review and Meta-Analysis American journal of epidemiology 2008;168 (11):1233-1246 [PubMed]
• Kastelein John J. P., Akdim Fatima, Stroes Erik S. G., Zwinderman Aeilko H., Bots Michiel L., Stalenhoef Anton F. H., Visseren Frank L. J., Sijbrands Eric J. G., Trip Mieke D., Stein Evan A., Gaudet Daniel, Duivenvoorden Raphael, Veltri Enrico P., Marais A. David, de Groot Eric Simvastatin with or without ezetimibe in familial hypercholesterolemia New England journal of medicine 2008;358 (14):1431-1443 [PubMed]
• Akdim Fatima, de Groot Eric, Kastelein John J. P. Simvastatin with or without ezetimibe in familial hypercholesterolemia - Reply New England journal of medicine 2008;359 (5):532
• Kastelein J. J. P., Akdim F., Stroes E. S. G., Zwinderman A. H., Bots M. L., Stalenhoef A. F. H., Visseren F. L. J., Sijbrands E. J. G., Trip M. D., Stein E. A., Gaudet D., Duivenvoorden R., Veltri E. P., Marais A. D., de Groot E. Simvastatin with or without ezetimibe in familial hypercholesterolemia (vol 358, pg 1431, 2008) New England journal of medicine 2008;358 (18):1977
• van Leuven S. I., Franssen R., Kastelein J. J., Levi M. [=Marcel M.], Stroes E. S. G., Tak P. P. Systemic inflammation as a risk factor for atherothrombosis Rheumatology (Oxford, England) 2008;47 (1):3-7 [PubMed]
• Meuwese Marijn C. Targeting the vessel wall in cardiovascular prevention 2008. 262p. ISBN 9789085594024. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Stroes E. S. G., Vink H.)
• Akdim Fatima, Kastelein John J. P., Gaudet Daniel The ENHANCE study and marketing ezetimibe JAMA 2008;299 (23):2747-2747; author reply 2748 [PubMed]
• Holleboom Adriaan G., Vergeer Menno, Hovingh G. Kees, Kastelein John Jp, Kuivenhoven Jan Albert The value of HDL genetics Current opinion in lipidology 2008;19 (4):385-394 [PubMed]
• Koeijvoets Kristel C. M. C., van der Net Jeroen B., van Rossum Elisabeth F. C., Steyerberg Ewout W., Defesche Joep C., Kastelein John J. P., Lamberts Steven W. J., Sijbrands Eric J. G. Two Common Haplotypes of the Glucocorticoid Receptor Gene Are Associated with Increased Susceptibility to Cardiovascular Disease in Men with Familial Hypercholesterolemia Journal of clinical endocrinology and metabolism 2008;93 (12):4902-4908 [PubMed]
• Kastelein John J. P., de Groot Eric Ultrasound imaging techniques for the evaluation of cardiovascular therapies European heart journal 2008;29 (7):849-858 [PubMed]
• Bredie Sebastian J. H., Stroes E. S. G., Kastelein J. J. P., Jukema J. W. Van lipidenmetabolisme naar behandelingin: E. E. van der Wall, F. Van de Werf, F. Zijlstra, editors. Cardiologie. Houten: Bohn Stafleu Van Loghum; 2008. p. 23-32, ISBN 9789031348299

2007

• Rip Jaap, Sierts Jeroen A., Vaessen Stefan F. C., Kastelein John J. P., Twisk Jaap, Kuivenhoven Jan Albert Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice Atherosclerosis 2007;194 (1):55-61 [PubMed]
• Penning-van Beest Fernie J. A., Termorshuizen Fabian, Goettsch Wim G., Klungel Olaf H., Kastelein John J. P., Herings Ron M. C. Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study European heart journal 2007;28 (2):154-159 [PubMed]
• Akdim Fatima, El Harchaoui Karim, Stroes Erik S. G., Kastelein John J. P. Antisense apolipoprotein B-100 as novel treatment for hypercholesterolemia: focus on ISIS 301012 FUTURE LIPIDOLOGY 2007;2 (4):387-393
• Akdim Fatima, Stroes Erik S. G., Kastelein John J. P. Antisense apolipoprotein B therapy: where do we stand? Current opinion in lipidology 2007;18 (4):397-400 [PubMed]
• Birjmohun Rakesh S., Dallinga-Thie Geesje M., Kuivenhoven Jan Albert, Stroes Erik S. G., Otvos James D., Wareham Nicholas J., Luben Robert, Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Apolipoprotein A-II is inversely associated with risk of future coronary artery disease Circulation 2007;116 (18):2029-2035 [PubMed]
• Birjmohun Rakesh S., Bisoendial Radjesh J., van Leuven Sander I., Ackermans Marlette, Zwinderman Aelko, Kastelein John J. P., Stroes Erik S. G., Sauerwein Hans P. A single bolus infusion of C-reactive protein increases gluconeogenesis and plasma glucose concentration in humans Metabolism: clinical and experimental 2007;56 (11):1576-1582 [PubMed]
• Avis H. J., Vissers M. N., Stein E. A., Wijburg F. A., Trip M. D., Kastelein J. J. P., Hutten B. A. A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia Arteriosclerosis, thrombosis, and vascular biology 2007;27 (8):1803-1810 [PubMed]
• Duivenvoorden Raphael, Nederveen Aart J., de Groot Eric, Kastelein John J. P. Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs Current opinion in lipidology 2007;18 (6):613-621 [PubMed]
• Ridker Paul M., Fonseca Francisco A. H., Genest Jacques, Gotto Antonio M., Kastelein John J. P., Khurmi Nardev S., Koenig Wolfgang, Libby Peter, Lorenzatti Alberto J., Nordestgaard Borge G., Shepherd James, Willerson James T., Glynn Robert J. Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein American journal of cardiology 2007;100 (11):1659-1664 [PubMed]
• Rana J. S., Nieuwdorp M., Jukema J. W., Kastelein J. J. P. Cardiovascular metabolic syndrome - an interplay of, obesity, inflammation, diabetes and coronary heart disease Diabetes, obesity & metabolism 2007;9 (3):218-232 [PubMed]
• Bots Michiel L., Baldassarre Damiano, Simon Alain, de Groot Eric, O'Leary Daniel H., Riley Ward, Kastelein John J., Grobbee Diederick E. Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? European heart journal 2007;28 (4):398-406 [PubMed]
• Arsenault Benoit J., Lemieux Isabelle, Després Jean-Pierre, Wareham Nicholas J., Luben Robert, Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study European heart journal 2007;28 (22):2770-2777 [PubMed]
• van der Steeg Wim A., Hovingh G. Kees, Klerkx Anke H. E. M., Hutten Barbara A., Nootenboom Inge C., Levels Johannes H. M., van Tol Arie, Dallinga-Thie Gees M., Zwinderman Aeilko H., Kastelein John J. P., Kuivenhoven Jan Albert Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians Journal of lipid research 2007;48 (3):674-682 [PubMed]
• Bisoendial Radjesh J., Kastelein John J. P., Stroes Erik S. G. C-reactive protein and atherogenesis: from fatty streak to clinical event Atherosclerosis 2007;195 (2):e10-e18 [PubMed]
• Kastelein John J. P., van Leuven Sander I., Evans Gregory W., Riley Ward A., Revkin James H., Shear Charles L., Bots Michiel L. Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis Current medical research and opinion 2007;23 (4):885-894 [PubMed]
• Rana J. S., Boekholdt S. M., Ridker P. M., Jukema J. W., Luben R., Bingham S. A., Day N. E., Wareham N. J., Kastelein J. J. P., Khaw K.-T. Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study Journal of internal medicine 2007;262 (6):678-689 [PubMed]
• Ozsoy Riza C., van der Steeg Wim A., Kastelein John J. P., Arisz Lambertus, Koopman Marion G. Dyslipidaemia as predictor of progressive renal failure and the impact of treatment with atorvastatin Nephrology, dialysis, transplantation 2007;22 (6):1578-1586 [PubMed]
• van der Steeg W. A., Kastelein J. J. P. Dyslipidemiein: G. K. Hovingh, G. A. Somsen, editors. Probleemgeoriënteerd denken in de cardiologie en vasculaire geneeskunde; een praktijkboek voor de opleiding en de kliniek. Utrecht: De Tijdstroom; 2007. p. 223-230, ISBN 9789058981080
• Khush Kiran K., Waters David D., Bittner Vera, Deedwania Prakash C., Kastelein John J. P., Lewis Sandra J., Wenger Nanette K. Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) study Circulation 2007;115 (5):576-583 [PubMed]
• Shepherd James, Kastelein John J. P., Bittner Vera, Deedwania Prakash, Breazna Andrei, Dobson Stephen, Wilson Daniel J., Zuckerman Andrea, Wenger Nanette K. Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study Clinical journal of the American Society of Nephrology 2007;2 (6):1131-1139 [PubMed]
• Schouten Olaf, Hoeks Sanne E., Welten Gijs M. J. M., Davignon Jean, Kastelein John J. P., Vidakovic Radosav, Feringa Harm H. H., Dunkelgrun Martin, van Domburg Ron T., Bax Jeroen J., Poldermans Don Effect of statin withdrawal on frequency of cardiac events after vascular surgery American journal of cardiology 2007;100 (2):316-320 [PubMed]
• Kastelein John J. P., van Leuven Sander I., Burgess Leslie, Evans Greg W., Kuivenhoven Jan A., Barter Philip J., Revkin James H., Grobbee Diederick E., Riley Ward A., Shear Charles L., Duggan William T., Bots Michiel L. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia New England journal of medicine 2007;356 (16):1620-1630 [PubMed]
• Bisoendial Radjesh J., Kastelein John J. P., Peters Stephan L. M., Levels Johannes H. M., Birjmohun Rakesh, Rotmans Joris I., Hartman Daniel, Meijers Joost C. M., Levi Marcel, Stroes Erik S. G. Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects Journal of lipid research 2007;48 (4):952-960 [PubMed]
• Sankatsing Raaj R., Wit Ferdinand W., Pakker Nadine, Vyankandondera Joseph, Mmiro Francis, Okong Pius, Kastelein John J., Lange Joep M., Stroes Erik S., Reiss Peter Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy Journal of infectious diseases 2007;196 (1):15-22 [PubMed]
• Barter Philip J., Caulfield Mark, Eriksson Mats, Grundy Scott M., Kastelein John J. P., Komajda Michel, Lopez-Sendon Jose, Mosca Lori, Tardif Jean-Claude, Waters David D., Shear Charles L., Revkin James H., Buhr Kevin A., Fisher Marian R., Tall Alan R., Brewer Bryan Effects of torcetrapib in patients at high risk for coronary events New England journal of medicine 2007;357 (21):2109-2122 [PubMed]
• Nierman Melchior C., Rip Jaap, Kuivenhoven Jan Albert, Sakai Naohiko, Kastelein John J. P., de Sain-van der Velden Monique G. M., Stroes Erik S. G., Prinsen Berthil H. C. M. T. Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes Atherosclerosis 2007;194 (2):446-451 [PubMed]
• van Leuven Sander I., Hezemans Rachel, Levels Johannes H., Snoek Susan, Stokkers Pieter C., Hovingh G. Kees, Kastelein John J. P., Stroes Erik S., de Groot Eric, Hommes Daan W. Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease Journal of lipid research 2007;48 (12):2640-2646 [PubMed]
• Vaessen Stefan F. C., Twisk Jaap, Kastelein John J. P., Kuivenhoven Jan Albert Gene therapy in disorders of lipoprotein metabolism Current gene therapy 2007;7 (1):35-47 [PubMed]
• Barter Philip, Gotto Antonio M., LaRosa John C., Maroni Jaman, Szarek Michael, Grundy Scott M., Kastelein John J. P., Bittner Vera, Fruchart Jean-Charles HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events New England journal of medicine 2007;357 (13):1301-1310 [PubMed]
• Birjmohun Rakesh S., van Leuven Sander I., Levels Johannes H. M., van 't Veer Cornelis, Kuivenhoven Jan Albert, Meijers Joost C. M., Levi Marcel, Kastelein John J. P., van der Poll Tom, Stroes Erik S. G. High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans Arteriosclerosis, thrombosis, and vascular biology 2007;27 (5):1153-1158 [PubMed]
• Duivenvoorden Raphael, Kastelein J. J. P., de Groot E. Imaging modalities as tools for the investigation of atherosclerosis and atherosclerotic diseasein: G. Assmann, editors. International Cardiovascular Prevention Task Force. Münster, Duitsland: s.n.; 2007.
• Souverein Olga W., Defesche Joep C., Zwinderman Aeilko H., Kastelein John J. P., Tanck Michael W. T. Influence of LDL-receptor mutation type on age at first cardiovascular event in patients with familial hypercholesterolaemia European heart journal 2007;28 (3):299-304 [PubMed]
• Nieuwdorp M. Metabolic and vascular dysfunction during hyperglycemia induced inflammation. The role of the endothelial glycocalyx on vascular homeostasis in vivo 2007. 158p. ISBN 9789090221038. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hoekstra Joost B. L., Kastelein John J. P.; Co-supervisors: Stroes Erik S. G., Vink Hans)
• Nieuwdorp M., Stroes E. S. G., Kastelein J. J. P. Normalization of metabolic syndrome using fenofibrate, metformin or their combination Diabetes, obesity & metabolism 2007;9 (6):869-878 [PubMed]
• Nieuwdorp M., Holleman F., de Groot E., Vink H., Gort J., Kontush A., Chapman M. J., Hutten B. A., Brouwer C. B., Hoekstra J. B. L., Kastelein J. J. P., Stroes E. S. G. Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis Diabetologia 2007;50 (6):1288-1293 [PubMed]
• Pinedo Sabine, Vissers Maud N., von Bergmann Klaus, Elharchaoui Karim, Lütjohann Dieter, Luben Robert, Wareham Nicholas J., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study Journal of lipid research 2007;48 (1):139-144 [PubMed]
• Akdim Fatima, van Leuven Sander I., Kastelein John J. P., Stroes Erik S. G. Pleiotropic effects of statins: stabilization of the vulnerable atherosclerotic plaque? Current pharmaceutical design 2007;13 (10):1003-1012 [PubMed]
• Birjmohun Rakesh S., Stroes Erik S. G., Kastelein John J. P. Raising high-density lipoprotein cholesterol for better prevention of cardiovascular disease FUTURE LIPIDOLOGY 2007;1 (1):47-54
• Kastelein John J. P. Refocusing on use of cholesteryl ester transfer protein inhibitors American journal of cardiology 2007;100 (11 A):n47-n52 [PubMed]
• van der Steeg Wim A., Boekholdt S. Matthijs, Stein Evan A., El-Harchaoui Karim, Stroes Erik S. G., Sandhu Manjinder S., Wareham Nicholas J., Jukema J. Wouter, Luben Robert, Zwinderman Aeilko H., Kastelein John J. P., Khaw Kay-Tee Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk Annals of internal medicine 2007;146 (9):640-648 [PubMed]
• LaRosa John C., Grundy Scott M., Kastelein John J. P., Kostis John B., Greten Heiner Safety and efficacy of atorvastatin-induced very low-density lipoprotein cholesterol levels in patients with coronary heart disease (a post hoc analysis of the treating to new targets [TNT] study) American journal of cardiology 2007;100 (5):747-752 [PubMed]
• Birjmohun R. S., Kastelein J. J. P., Poldermans D., Stroes E. S. G., Hostalek U., Assmann G. Safety and tolerability of prolonged-release nicotinic acid in statin-treated patients Current medical research and opinion 2007;23 (7):1707-1713 [PubMed]
• Meuwese Marijn C., Stroes Erik S. G., Hazen Stanley L., van Miert Joram N., Kuivenhoven Jan Albert, Schaub Robert G., Wareham Nicholas J., Luben Robert, Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Serum Myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals - The EPIC-Norfolk prospective population study Journal of the American College of Cardiology 2007;50 (2):159-165 [PubMed]
• Rodenburg Jessica, Vissers Maud N., Wiegman Albert, van Trotsenburg A. S. Paul, van der Graaf Anouk, de Groot Eric, Wijburg Frits A., Kastelein John J. P., Hutten Barbara A. Statin treatment in children with familial hypercholesterolemia - The younger, the better Circulation 2007;116 (6):664-668 [PubMed]
• Ozsoy Riza C. The dyslipidemia of chronic renal failure and the effects of statin therapy 2007. 160p. ISBN 9789090217475. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Arisz Lambertus, Kastelein John J. P.; Co-supervisor: Koopman Marion G.)
• El Harchaoui Karim, van der Steeg Wim A., Stroes Erik S. G., Kastelein John J. P. The role of CETP inhibition in dyslipidemia Current atherosclerosis reports 2007;9 (2):125-133 [PubMed]
• Bots Michiel L., Visseren Frank L., Evans Gregory W., Riley Ward A., Revkin James H., Tegeler Charles H., Shear Charles L., Duggan William T., Vicari Ralph M., Grobbee Diederick E., Kastelein John J. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial Lancet 2007;370 (9582):153-160 [PubMed]
• El Harchaoui Karim, van der Steeg Wim A., Stroes Erik S. G., Kuivenhoven Jan Albert, Otvos James D., Wareham Nicholas J., Hutten Barbara A., Kastelein John J. P., Khaw Kay-Tee, Boekholdt S. Matthijs Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study Journal of the American College of Cardiology 2007;49 (5):547-553 [PubMed]
• Büller H. R., Kastelein J. J. P., Stroes E. S. G. Vasculaire Geneeskunde, 3e herziene drukAlphen aan de Rijn: Van Zuiden Communications; 2007. ISBN 9789085231516

2006

• Rip Jaap, van Dijk Ko Willems, Sierts Jeroen A., Kastelein John J. P., Twisk Jaap, Kuivenhoven Jan Albert AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2006;1761 (10):1163-1168 [PubMed]
• Koeijvoets Kristel C. M. C., van Rossum Elisabeth F. C., Dallinga-Thie Geesje M., Steyerberg Ewout W., Defesche Joep C., Kastelein John J. P., Lamberts Steven W. J., Sijbrands Eric J. G. A functional polymorphism in the glucocorticoid receptor gene and its relation to cardiovascular disease risk in familial hypercholesterolemia Journal of clinical endocrinology and metabolism 2006;91 (10):4131-4136 [PubMed]
• Meuwese Marijn C., Franssen Remco, Stroes Erik S. G., Kastelein John J. P. And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors Current opinion in lipidology 2006;17 (4):426-430 [PubMed]
• Vaessen Stefan F. C., Schaap Frank G., Kuivenhoven Jan-Albert, Groen Albert K., Hutten Barbara A., Boekholdt S. Matthijs, Hattori Hiroaki, Sandhu Manjinder S., Bingham Sheila A., Luben Robert, Palmen Jutta A., Wareham Nicholas J., Humphries Steve E., Kastelein John J. P., Talmud Philippa J., Khaw Kay-Tee Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study Journal of lipid research 2006;47 (9):2064-2070 [PubMed]
• Maitland-van der Zee Anke-Hilse, Jukema J. Wouter, Zwinderman Aeilko H., Hallman D. Michael, de Boer Anthonius, Kastelein John J. P., de Knijff Peter Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS) Acta cardiologica 2006;61 (3):327-331 [PubMed]
• van Leuven S. I., Kastelein J. J. P., D'Cruz D. P., Hughes G. R., Stroes E. S. Atherogenesis in rheumatology Lupus 2006;15 (3):117-121 [PubMed]
• Klerkx Anke H. E. M., El Harchaoui Karim, van der Steeg Wim A., Boekholdt S. Matthijs, Stroes Erik S. G., Kastelein John J. P., Kuivenhoven Jan Albert Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis Arteriosclerosis, thrombosis, and vascular biology 2006;26 (4):706-715 [PubMed]
• Boekholdt S. M., Souverein O. W., Tanck M. W. T., Hovingh G. K., Kuivenhoven J. A., Peters R. I. G., Jansen H., Schiffers P. M. H., van der Wall E. E., Doevendans P. A., Reitsma P. H., Zwinderman A. H., Kastelein J. J. P., Jukema J. W. Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels Clinical genetics 2006;69 (3):263-270 [PubMed]
• Ross Colin J. D., Twisk Jaap, Bakker Andrew C., Miao Fudan, Verbart Dennis, Rip Jaap, Godbey Tamara, Dijkhuizen Paul, Hermens Wim T. J. M. C., Kastelein John J. P., Kuivenhoven Jan Albert, Meulenberg Janneke M., Hayden Michael R. Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation Human gene therapy 2006;17 (5):487-499 [PubMed]
• Boekholdt S. Matthijs, Hack C. Erik, Sandhu Manjinder S., Luben Robert, Bingham Sheila A., Wareham Nicholas J., Peters Ron J. G., Jukema J. Wouter, Day Nicholas E., Kastelein John J. P., Khaw Kay-Tee C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003 Atherosclerosis 2006;187 (2):415-422 [PubMed]
• Birjmohun R. S., van der Steeg W. A., Stroes E. S. G., Kastelein J. J. P. De rol van het 'high-density'-lipoproteine (HDL)-partikel in de atherogenese en de mogelijkheden om de concentratie daarvan te verhogen Nederlands tijdschrift voor geneeskunde 2006;150 (41):2245-2250 [PubMed]
• van Aalst-Cohen Emily S., Jansen Angelique C. M., Tanck Michael W. T., Defesche Joep C., Trip Mieke D., Lansberg Peter J., Stalenhoef Anton F. H., Kastelein John J. P. Diagnosing familial hypercholesterolaemia: the relevance of genetic testing European heart journal 2006;27 (18):2240-2246 [PubMed]
• Waters David D., LaRosa John C., Barter Philip, Fruchart Jean-Charles, Gotto Antonio M., Carter Roddy, Breazna Andrei, Kastelein John J. P., Grundy Scott M. Effects of high-dose atorvastatin on cerebrovascular events in patients with stable coronary disease in the TNT (treating to new targets) study Journal of the American College of Cardiology 2006;48 (9):1793-1799 [PubMed]
• Nieuwdorp Max, Mooij Hans L., Kroon Jojanneke, Atasever Bektas, Spaan Jos A. E., Ince Can, Holleman Frits, Diamant Michaela, Heine Robert J., Hoekstra Joost B. L., Kastelein John J. P., Stroes Erik S. G., Vink Hans Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes Diabetes 2006;55 (4):1127-1132 [PubMed]
• Ross C. J. D., Twisk J., Kuivenhoven J. A., Rip J., Kastelein J. J., Hayden M. R. Gene therapy with lipoprotein lipase variant S447X - Response Arteriosclerosis, thrombosis, and vascular biology 2006;26 (3):E25-E28
• Bisoendial R. J. High-density lipoprotein and C-reactive protein, friend and foe in cardiovascular disease 2006. 174p. ISBN 9789090209784. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Stroes E. S. G.)
• Vriend Joris W. J., de Groot Eric, de Waal Tim T., Zijta Frank M., Kastelein John J. P., Mulder Barbara J. M. Increased carotid and femoral intima-media thickness in patients after repair of aortic coarctation: influence of early repair American heart journal 2006;151 (1):242-247 [PubMed]
• Ueland T., Vissers M. N., Wiegman A., Rodenburg J., Hutten B., Gullestad L., Ose L., Rifai N., Ridker P. M., Kastelein J. J. P., Aukrust P., Semb A. G. Increased inflammatory markers in children with familial hypercholesterolaemia European journal of clinical investigation 2006;36 (3):147-152 [PubMed]
• Rana J. S., Jansen A. C., Zwinderman A. H., van Aalst-Cohen E. S., Jukema J. W., Trip M. D., Kastelein J. J. P. Lipoprotein (a) and risk of cardiovascular disease in patients with metabolic syndrome in a population of familial hypercholesterolaemia Journal of internal medicine 2006;260 (2):183-185 [PubMed]
• Rip J. Lipoprotein lipase, hypertriglyceridemia and atherosclerosis 2006. 242p. ISBN 9789090209036. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Kuivenhoven J. A.)
• Rip Jaap, Nierman Melchior C., Ross Colin J., Jukema Jan Wouter, Hayden Michael R., Kastelein John J. P., Stroes Erik S. G., Kuivenhoven Jan Albert Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation Arteriosclerosis, thrombosis, and vascular biology 2006;26 (6):1236-1245 [PubMed]
• Nierman M. C. Lipoprotein lipase S477X. From beneficial gene variant to gene therapy 2006. 254p. ISBN 9789090213101. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Stroes E. S. G., Kuivenhoven J. A.)
• Nieuwdorp Max, van Haeften Timon W., Gouverneur Mirella C. L. G., Mooij Hans L., van Lieshout Miriam H. P., Levi Marcel, Meijers Joost C. M., Holleman Frits, Hoekstra Joost B. L., Vink Hans, Kastelein John J. P., Stroes Erik S. G. Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo Diabetes 2006;55 (2):480-486 [PubMed]
• Rana Jamal S., Jansen Angelique C., Zwinderman Aeilko H., Nieuwdorp Max, van Aalst-Cohen Emily S., Jukema J. Wouter, Trip Mieke D., Kastelein John J. P. Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia Diabetes care 2006;29 (5):1125-1127 [PubMed]
• van Leuven S. I., Kastelein J. J. P., Hayden M. R., Stroes E. S. Mycophenolate mofetil as an immunomodulatory silver bullet in atherogenesis? Lupus 2006;15 (11 Suppl. S):11-17
• van Leuven Sander I., Kastelein John J. P., Allison Anthony C., Hayden Michael R., Stroes Erik S. G. Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles? Cardiovascular research 2006;69 (2):341-347 [PubMed]
• Rodenburg Jessica, Vissers Maud N., Wiegman Albert, Miller Elizabeth R., Ridker Paul M., Witztum Joseph L., Kastelein John J. P., Tsimikas Sotirios Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin Journal of the American College of Cardiology 2006;47 (9):1803-1810 [PubMed]
• Roest Mark, Rodenburg Jessica, Wiegman Albert, Kastelein John J. P., Voorbij Hieronymus A. M. Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia European journal of cardiovascular prevention and rehabilitation 2006;13 (3):464-466 [PubMed]
• Jakulj Lily, Vissers Maud N., Rodenburg Jessica, Wiegman Albert, Trip Mieke D., Kastelein John J. P. Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels Journal of pediatrics 2006;148 (4):495-500 [PubMed]
• Kastelein John J. P., Wedel Mark K., Baker Brenda F., Su John, Bradley Joann D., Yu Rosie Z., Chuang Emil, Graham Mark J., Crooke Rosanne M. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B Circulation 2006;114 (16):1729-1735 [PubMed]
• van der Graaf Anouk, Hutten Barbara A., Kastelein John J. P., Vissers Maud N. Premature cardiovascular disease in young women with heterozygous familial hypercholesterolemia Expert review of cardiovascular therapy 2006;4 (3):345-351 [PubMed]
• Deedwania Prakash, Barter Philip, Carmena Rafael, Fruchart Jean-Charles, Grundy Scott M., Haffner Steven, Kastelein John J. P., LaRosa John C., Schachner Holly, Shepherd James, Waters David D. Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study Lancet 2006;368 (9539):919-928 [PubMed]
• Kramer Anneke, Jansen Angelique C. M., van Aalst-Cohen Emily S., Tanck Michael W. T., Kastelein John J. P., Zwinderman Aeilko H. Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia BMC public health 2006;6:262 [PubMed]
• Goettsch W. G., Heintjes E. M., Kastelein J. J. P., Rabelink T. J., Johansson Saga, Herings R. M. C. Results from a rosuvastatin historical cohort study in more than 45,000 Dutch statin users, a PHARMO study Pharmacoepidemiology and drug safety 2006;15 (7):435-443 [PubMed]
• Walma E. P., Visseren F. L. J., Jukema J. W., Kastelein J. J. P., Hoes A. W., Stalenhoef A. F. H. Richtlijn 'diagnostiek en behandeling van familiaire hypercholesterolemie' van het College voor zorgverzekeringen Nederlands tijdschrift voor geneeskunde 2006;150 (1):18-23 [PubMed]
• Rip Jaap, Nierman Melchior C., Wareham Nicholas J., Luben Robert, Bingham Sheila A., Day Nicholas E., van Miert Joram N. I., Hutten Barbara A., Kastelein John J. P., Kuivenhoven Jan Albert, Khaw Kay-Tee, Boekholdt S. Matthijs Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study Arteriosclerosis, thrombosis, and vascular biology 2006;26 (3):637-642 [PubMed]
• Barter Philip J., Kastelein John J. P. Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease Journal of the American College of Cardiology 2006;47 (3):492-499 [PubMed]
• Ozsoy Riza C., van Leuven Sander I., Kastelein John J. P., Arisz Lambertus, Koopman Marion G. The dyslipidemia of chronic renal disease: effects of statin therapy Current opinion in lipidology 2006;17 (6):659-666 [PubMed]
• Barter P., Kastelein J. Translating today's science into clinical practice Atherosclerosis. Supplements 2006;7 (1):1-2

2005

• Monraats Pascalle S., Rana Jamal S., Zwinderman Aeilko H., de Maat Moniek P. M., Kastelein John P., Agema Willem R. P., Doevendans Pieter A. F., de Winter Robbert J., Tio René A., Waltenberger Johannes, Frants Rune R., van der Laarse Arnoud, van der Wall Ernst E., Jukema J. Wouter -455G/A polymorphism and preprocedural plasma levels of fibrinogen show no association with the risk of clinical restenosis in patients with coronary stent placement Thrombosis and haemostasis 2005;93 (3):564-569 [PubMed]
• Bots A. F. E., Kastelein J. J. P. Achieving lipid goals in real life: the Dutch DISCOVERY Study International journal of clinical practice 2005;59 (12):1387-1394 [PubMed]
• Bisoendial Radjesh J., Kastelein John J. P., Levels Johannes H. M., Zwaginga Jaap J., van den Bogaard Bas, Reitsma Pieter H., Meijers Joost C. M., Hartman Daniel, Levi Marcel, Stroes Erik S. G. Activation of inflammation and coagulation after infusion of C-reactive protein in humans Circulation research 2005;96 (7):714-716 [PubMed]
• Vriend Joris W. J., Engelfriet Peter M., de Groot Eric, Elsen Bart M., Kastelein John J. P., Mulder Barbara J. M. Age at repair and left ventricular mass in patients after repair of aortic coarctation Journal of thoracic and cardiovascular surgery 2005;130 (3):896-897 [PubMed]
• Cobbe S. M., Kastelein J. J. P. A symposium: Statin Therapy: Setting New Standards in the Management of Dyslipidaemia - Foreword EUROPEAN HEART JOURNAL SUPPLEMENTS 2005;7 (Suppl A):A3-A4
• van Leuven Sander I., Kastelein John J. P. Atorvastatin Expert opinion on pharmacotherapy 2005;6 (7):1191-1203 [PubMed]
• van Leuven Sander I., Kastelein John J. P., Hayden Michael R., d'Cruz David, Hughes Graham R., Stroes Erik S. Cardiovascular disease in systemic lupus erythematosus: has the time for action come? Current opinion in lipidology 2005;16 (5):501-506 [PubMed]
• Vriend J. W. J., de Groot E., Bouma B. J., Hrudova J., Kastelein J. J. P., Tijssen J. G. P., Mulder B. J. M. Carotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension Heart (British Cardiac Society) 2005;91 (7):962-963 [PubMed]
• Nierman Melchior C., Rip Jaap, Kuivenhoven Jan-Albert, van Raalte Daniel H., Hutten Barbara A., Sakai Naohiko, Kastelein John J. P., Stroes Erik S. G. Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance Metabolism: clinical and experimental 2005;54 (11):1499-1503 [PubMed]
• Boekholdt S. M., Sacks F. M., Jukema J. W., Shepherd J., Freeman D. J., McMahon A. D., Cambien F., Nicaud V., de Grooth G. J., Talmud P. J., Humphries S. E., Miller G. J., Eiriksdottir G., Gudnason V., Kauma H., Kakko S., Savolainen M. J., Arca M., Montali A., Liu S., Lanz H. J., Zwinderman A. H., Kuivenhoven J. A., Kastelein J. J. P. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment - Individual patient meta-analysis of 13,677 subjects Circulation 2005;111 (3):278-287 [PubMed]
• Kastelein John J. P., Sager Philip T., de Groot Eric, Veltri Enrico Comparison of ezetimibe plus simvastatin versus simvastatin monotherapy on atherosclerosis progression in familial hypercholesterolemia: Design and rationale of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial American heart journal 2005;149 (2):234-239 [PubMed]
• Ross Colin J. D., Liu Guoqing, Kuivenhoven Jan Albert, Twisk Jaap, Rip Jaap, van Dop Willemijn, Excoffon Katherine J. D. Ashbourne, Lewis Suzanne M. E., Kastelein John J., Hayden Michael R. Complete rescue of lipoprotein lipase-deficient mice by somatic gene transfer of the naturally occurring LPLS447X beneficial mutation Arteriosclerosis, thrombosis, and vascular biology 2005;25 (10):2143-2150 [PubMed]
• Hovingh G. Kees, Hutten Barbara A., Holleboom Adriaan G., Petersen Wilma, Rol Patrick, Stalenhoef Anton, Zwinderman Aeilko H., de Groot Eric, Kastelein John J. P., Kuivenhoven Jan Albert Compromised LCAT function is associated with increased atherosclerosis Circulation 2005;112 (6):879-884 [PubMed]
• Bisoendial Radjesh J., Hovingh G. Kees, El Harchaoui Karim, Levels Johannes H. M., Tsimikas Sotirios, Pu Kewei, Zwinderman Aeilko E., Kuivenhoven Jan Albert, Kastelein John J. P., Stroes Erik S. G. Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia Arteriosclerosis, thrombosis, and vascular biology 2005;25 (9):E133-E134 [PubMed]
• de Groot E., Hovingh G. K., Zwinderman A. H., Wiegman A., Smit A. J., Kastelein J. J. P. Data density curves of B-mode ultrasound arterial wall thickness measurements in unaffected control and at-risk populations International angiology 2005;24 (4):359-365 [PubMed]
• Cohen E. S. Diagnostic criteria and risk factors for cardiovascular in familial hypercholesterolemia 2005. 191p. ISBN 9789090191027. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Trip M. D., Lansberg P. J.)
• Kuivenhoven Jan Albert, de Grooth Greetje J., Kawamura Hitoshi, Klerkx Anke H., Wilhelm Francois, Trip Mieke D., Kastelein John J. P. Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with Pravastatin in type II dyslipidemia American journal of cardiology 2005;95 (9):1085-1088 [PubMed]
• Koeijvoets Kristel C. M. C., Wiegman Albert, Rodenburg Jessica, Defesche Joep C., Kastelein John J. P., Sijbrands Eric J. G. Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study Atherosclerosis 2005;180 (1):93-99 [PubMed]
• Birjmohun Rakesh S., Hutten Barbara A., Kastelein John J. P., Stroes Erik S. G. Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds - A meta-analysis of randomized controlled trials Journal of the American College of Cardiology 2005;45 (2):185-197 [PubMed]
• Nierman Melchior C., Prinsen Berthil H. C. M. T., Rip Jaap, Veldman Robert Jan, Kuivenhoven Jan Albert, Kastelein John J. P., de Sain-van der Velden Monique G. M., Stroes Erik S. G. Enhanced conversion of triglyceride-rich lipoproteins and increased low-density lipoprotein removal in LPLS447X carriers Arteriosclerosis, thrombosis, and vascular biology 2005;25 (11):2410-2415 [PubMed]
• Kastelein J. J. P., Sankatsing R. R. Ezetimibe/simvastatin (INEGY) in the treatment of hyperlipidaemia International journal of clinical practice 2005;59 (12):1464-1471 [PubMed]
• Rodenburg J. Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification 2005. 239p. ISBN 9789090196732. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Wiegman A., Vissers M. N., Hutten B. A.)
• Frisdal Eric, Klerkx Anke H. E. M., Le Goff Wilfried, Tanck Michael W. T., Lagarde Jean-Pierre, Jukema J. Wouter, Kastelein John J. P., Chapman M. John, Guerin Maryse Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study Human molecular genetics 2005;14 (18):2607-2618 [PubMed]
• Birjmohun R. M., Stroes E. S. G., Kastelein J. J. P. Future strategies in the management of dyslipidemia Future cardiology 2005;1 (2):127-130
• Nierman M. C., Rip J., Twisk J., Meulenberg J. J. M., Kastelein J. J. P., Stroes E. S. G., Kuivenhoven J. A. Gene therapy for genetic lipoprotein lipase deficiency: from promise to practice Netherlands journal of medicine 2005;63 (1):14-19 [PubMed]
• Rip Jaap, Nierman Melchior C., Sierts Jeroen A., Petersen Wilma, van den Oever Karin, van Raalte Daniel, Ross Colin J. D., Hayden Michael R., Bakker Andrew C., Dijkhuizen Paul, Hermens Wim T., Twisk Jaap, Stroes Erik, Kastelein John J. P., Kuivenhoven Jan Albert, Meulenberg Janneke M. Gene therapy for lipoprotein lipase deficiency: Working toward clinical application Human gene therapy 2005;16 (11):1276-1286 [PubMed]
• Boekholdt S. M. Genetic and biochemical risk factors in coronary artery disease 2005. 280p. ISBN 9789090191744. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Peters R. J. G.; Co-supervisors: Jukema J. W., Reitsma P. H.)
• Jansen Angelique C. M., van Aalst-Cohen Emily S., Tanck Michael W. T., Cheng Suzanne, Fontecha Marcel R., Li Jia, Defesche Joep C., Kastelein John J. P. Genetic determinants of cardiovascular disease risk in familial hypercholesterolemia Arteriosclerosis, thrombosis, and vascular biology 2005;25 (7):1475-1481 [PubMed]
• Fouchier S. W. Genetic determinants of cholesterol homeostasis 2005. 149p. ISBN 9789090193199. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Defesche J. C.)
• van Aalst-Cohen Emily S., Jansen Angelique C. M., Boekholdt S. Matthijs, Tanck Michael W. T., Fontecha Marcel R., Cheng Suzanne, Li Jia, Defesche Joep C., Kuivenhoven Jan Albert, Kastelein John J. P. Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia European journal of human genetics 2005;13 (10):1137-1142 [PubMed]
• Jansen Angelique C. M., van Aalst-Cohen Emily S., Hutten Barbara A., Büller Harry R., Kastelein John J. P., Prins Martin H. Guidelines were developed for data collection from medical records for use in retrospective analyses Journal of clinical epidemiology 2005;58 (3):269-274 [PubMed]
• Sankatsing Raaj R., Fouchier Sigrid W., de Haan Stefan, Hutten Barbara A., de Groot Eric, Kastelein John J. P., Stroes Erik S. G. Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia Arteriosclerosis, thrombosis, and vascular biology 2005;25 (9):1979-1984 [PubMed]
• Pedersen Terje R., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Tikkanen Matti J., Holme Ingar, Larsen Mogens Lytken, Bendiksen Fredrik S., Lindahl Christina, Szarek Michael, Tsai John High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial JAMA 2005;294 (19):2437-2445 [PubMed]
• Fouchier S. W., Sankatsing R. R., Peter J., Castillo S., Pocovi M., Alonso R., Kastelein J. J. P., Defesche J. C. High frequency of APOB gene mutations causing familial hypobetalipoproteinaemia in patients of Dutch and Spanish descent Journal of medical genetics 2005;42 (4):e23 [PubMed]
• van der Steeg W. A., El-Harchaoui K., Kuivenhoven J. A., Kastelein J. J. P. Increasing high-density lipoprotein cholesterol through cholesteryl ester transfer protein inhibition: a next step in the fight against cardiovascular disease? Current drug targets. Cardiovascular & haematological disorders 2005;5 (6):481-488 [PubMed]
• van Himbergen Thomas M., Roest Mark, de Graaf Jacqueline, Jansen Eugène H. J. M., Hattori Hiroaki, Kastelein John J. P., Voorbij Hieronymus A. M., Stalenhoef Anton F. H., van Tits Lambertus J. H. Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia Journal of lipid research 2005;46 (3):445-451 [PubMed]
• Hovingh G. Kees, de Groot Eric, van der Steeg Wim, Boekholdt S. Matthijs, Hutten Barbara A., Kuivenhoven Jan Albert, Kastelein John J. P. Inherited disorders of HDL metabolism and atherosclerosis Current opinion in lipidology 2005;16 (2):139-145 [PubMed]
• Jakulj Lily, Trip Mieke D., Sudhop Thomas, von Bergmann Klaus, Kastelein John J. P., Vissers Maud N. Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels Journal of lipid research 2005;46 (12):2692-2698 [PubMed]
• Bisoendial Radjesh, Kastelein John, Stroes Erik In response to van den Berg et al: on the direct actions of CRP in humans Circulation research 2005;97 (7):e71 [PubMed]
• LaRosa John C., Grundy Scott M., Waters David D., Shear Charles, Barter Philip, Fruchart Jean-Charles, Gotto Antonio M., Greten Heiner, Kastelein John J. P., Shepherd James, Wenger Nanette K. Intensive lipid lowering with atorvastatin in patients with stable coronary disease New England journal of medicine 2005;352 (14):1425-1435 [PubMed]
• Bisoendial Radjesh, Birjmohun Rakesh, Keller Tymen, van Leuven Sander, Levels Han, Levi Marcel, Kastelein John, Stroes Erik In vivo effects of C-reactive protein (CRP)-infusion into humans Circulation research 2005;97 (12):e115-e116 [PubMed]
• Monraats Pascalle S., Rana Jamal S., Nierman Melchior C., Pires Nuno M. M., Zwinderman Aeilko H., Kastelein John J. P., Kuivenhoven Jan Albert, de Maat Moniek P. M., Rittersma Saskia Z. H., Schepers Abbey, Doevendans Pieter A. F., de Winter Robbert J., Tio René A., Frants Rune R., Quax Paul H. A., van der Laarse Arnoud, van der Wall Ernst E., Jukema J. Wouter Lipoprotein lipase gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention Journal of the American College of Cardiology 2005;46 (6):1093-1100 [PubMed]
• van Wissen Sanne, Smilde Tineke J., Trip Mieke D., Stalenhoef Anton F. H., Kastelein John J. P. Long-term safety and efficacy of high-dose Atorvastatin treatment in patients with familial hypercholesterolemia American journal of cardiology 2005;95 (2):264-266 [PubMed]
• Koeijvoets Kristel C. M. C., Rodenburg Jessica, Hutten Barbara A., Wiegman Albert, Kastelein John J. P., Sijbrands Eric J. G. Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia - Substudy of an intima-media thickness trial Circulation 2005;112 (20):3168-3173 [PubMed]
• Fouchier Sigrid W., Rodenburg Jessica, Defesche Joep C., Kastelein John J. P. Management of hereditary dyslipidaemia; the paradigm of autosomal dominant hypercholesterolaemia European journal of human genetics 2005;13 (12):1247-1253 [PubMed]
• Kastelein John Metabolic and cardiovascular disease: complications and consequences Atherosclerosis. Supplements 2005;6 (2):1-2 [PubMed]
• Rana Jamal S., Monraats Pascalle S., Zwinderman Aeilko H., de Maat Moniek P. M., Kastelein John J. P., Doevendans Pieter A. F., de Winter Robbert J., Tio René A., Frants Rune R., van der Laarse Arnoud, van der Wall Ernst E., Jukema J. Wouter Metabolic syndrome and risk of restenosis in patients undergoing percutaneous coronary intervention Diabetes care 2005;28 (4):873-877 [PubMed]
• Kastelein John J. P. Modifying plasma low-density lipoprotein and high-density lipoprotein cholesterol: what combinations are available in the future? American journal of cardiology 2005;96 (9A):20K-27K; discussion 34K-35K [PubMed]
• Hovingh G. K. Molecular defects in the metabolism of the HDL particle and the consequences for atherosclerosis progression 2005. 251p. ISBN 9789090192444. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Groen A. K., Kuivenhoven J. A.)
• Wegman Jurgen J., Hu Xiaofeng, Tan Hendra, Bergen Arthur A. B., Trip Mieke D., Kastelein John J. P., Smulders Yvo M. Patients with premature coronary artery disease who carry the ABCC6 R1141X mutation have no Pseudoxanthoma Elasticum phenotype International journal of cardiology 2005;100 (3):389-393 [PubMed]
• Vriend Joris W. J., Zwinderman Aeiko H., de Groot Eric, Kastelein John J. P., Bouma Berto J., Mulder Barbara J. M. Predictive value of mild, residual descending aortic narrowing for blood pressure and vascular damage in patients after repair of aortic coarctation European heart journal 2005;26 (1):84-90 [PubMed]
• Rana Jamal S., Monraats Pascalle S., Zwinderman Aeilko H., de Maat Moniek P. M., Kastelein John J. P., Agema Willem R. P., Doevendans Pieter A. F., de Winter Robbert J., Tio René A., Waltenberger Johannes, Frants Rune R., van der Laarse Arnoud, van der Wall Ernst E., Jukema J. Wouter Pre-procedural levels of erythrocyte sedimentation rate (ESR) and risk of clinical restenosis in patients with percutaneous coronary intervention and coronary stent placement Thrombosis and haemostasis 2005;94 (4):892-894 [PubMed]
• Boekholdt S. Matthijs, Keller Tymen T., Wareham Nicholas J., Luben Robert, Bingham Sheila A., Day Nicholas E., Sandhu Manjinder S., Jukema J. Wouter, Kastelein John J. P., Hack C. Erik, Khaw Kay-Tee Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women - The EPIC-Norfolk Prospective Population study Arteriosclerosis, thrombosis, and vascular biology 2005;25 (4):839-846 [PubMed]
• van der Harst P., Kastelein J. J. P., van Gilst W. H. Statinen: voorlopig niet als regel maximaal doseren Nederlands tijdschrift voor geneeskunde 2005;149 (46):2589-2589; author reply 2590 [PubMed]
• Sankatsing Raaj R., de Groot Eric, Jukema J. Wouter, de Feyter Pim J., Pennell Dudley J., Schoenhagen Paul, Nissen Steven E., Stroes Erik S. G., Kastelein John J. P. Surrogate markers for atherosclerotic disease Current opinion in lipidology 2005;16 (4):434-441 [PubMed]
• Ozsoy R. C., Koopman M. G., Kastelein J. J. P., Arisz L. The acute effect of atorvastatin on proteinuria in patients with chronic glomerulonephritis Clinical nephrology 2005;63 (4):245-249 [PubMed]
• Rana J. S. The cardiovascular metabolic syndrome 2005. 229p. ISBN 9789090198040. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisor: Jukema J. W.)
• Nieuwdorp Max, Meuwese Marijn C., Vink Hans, Hoekstra Joost B. L., Kastelein John J. P., Stroes Erik S. G. The endothelial glycocalyx: a potential barrier between health and vascular disease Current opinion in lipidology 2005;16 (5):507-511 [PubMed]
• Rotmans J. I. Therapeutic strategies to prevent stenosis in arteriovenous grafts for hemodialysis. Studies in a porcine arteriovenous graft model 2005. 160p. ISBN 9789090186344. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Stroes E. S. G., Pasterkamp G.)
• Kastelein J. J. P. The realities of dyslipidaemia: what do the studies tell us? EUROPEAN HEART JOURNAL SUPPLEMENTS 2005;7 (F):F27-F33
• Fouchier Sigrid W., Kastelein John J. P., Defesche Joep C. Update of the molecular basis of familial hypercholesterolemia in The Netherlands Human mutation 2005;26 (6):550-556 [PubMed]
• Roest Mark, Jansen Angelique C. M., Barendrecht Arjan, Leus Frank R., Kastelein John J. P., Voorbij Hieronymus A. M. Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia Clinical biochemistry 2005;38 (2):123-127 [PubMed]
• Kastelein John J. P., Fouchier Sigrid W., Defesche Joep C. What promise does PCSK9 hold? Journal of the American College of Cardiology 2005;45 (10):1620-1621 [PubMed]

2004

• Rodenburg J., Wiegman A., Vissers M. N., Kastelein J. J. P., Stalenhoef A. F. H. A boy with autosomal recessive hypercholesterolaemia Netherlands journal of medicine 2004;62 (3):89-93 [PubMed]
• Homsma S. J., Lansberg P. J., Kastelein J. J. Actieve opsporing van patiënten met familiaire hypercholesterolemie en verzekerbaarheid voor levens- en arbeidsongeschiktheidsverzekeringen Nederlands tijdschrift voor geneeskunde 2004;148 (10):493-496 [PubMed]
• Defesche Joep C., Lansberg Peter J., Umans-Eckenhausen Marina A. W., Kastelein John J. P. Advanced method for the identification of patients with inherited hypercholesterolemia Seminars in vascular medicine 2004;4 (1):59-65 [PubMed]
• Agema Willem R. P., de Maat Moniek P. M., Zwinderman Aeilko H., Kastelein John J. P., Rabelink Ton J., van Boven Ad J., Feskens Edith J. M., Boer Jolanda M. A., van der Wall Ernst E., Jukema J. Wouter An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men Clinical science (London, England 2004;107 (3):255-261 [PubMed]
• Hovingh G. Kees, Brownlie Alison, Bisoendial Radjesh J., Dube Marie Pierre, Levels Johannes H. M., Petersen Wilma, Dullaart Robin P. F., Stroes Erik S. G., Zwinderman Aeilko H., de Groot Eric, Hayden Michael R., Kuivenhoven Jan Albert, Kastelein John J. P. A novel ApoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease Journal of the American College of Cardiology 2004;44 (7):1429-1435 [PubMed]
• de Grooth Greetje J., Klerkx Anke H. E. M., Stroes Erik S. G., Stalenhoef Anton F. H., Kastelein John J. P., Kuivenhoven Jan Albert A review of CETP and its relation to atherosclerosis Journal of lipid research 2004;45 (11):1967-1974 [PubMed]
• Wiegman Albert, de Groot Eric, Hutten Barbara A., Rodenburg Jessica, Gort Johan, Bakker Henk D., Sijbrands Eric J. G., Kastelein John J. P. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia Lancet 2004;363 (9406):369-370 [PubMed]
• Kastelein John J. P., de Groot Eric, Sankatsing Raaj Atherosclerosis measured by B-mode ultrasonography: Effect of statin therapy on disease progression American journal of medicine 2004;116 (Suppl 6A):31S-36S [PubMed]
• Kastelein John Cardiovascular risk--through the ages Atherosclerosis. Supplements 2004;5 (2):1-2 [PubMed]
• Vriend J. J. W., de Groot E., Kastelein J. J. P., Mulder B. J. M. Carotid and femoral B-mode ultrasound intima-media thickness measurements in adult post-coarctectomy patients International angiology 2004;23 (1):41-46 [PubMed]
• Boekholdt S. Matthijs, Kuivenhoven Jan-Albert, Hovingh G. Kees, Jukema J. Wouter, Kastelein John J. P., van Tol Arie CETP gene variation: relation to lipid parameters and cardiovascular risk Current opinion in lipidology 2004;15 (4):393-398 [PubMed]
• Klerkx A. H. E. M., de Grooth G. J., Zwinderman A. H., Jukema J. W., Kuivenhoven J. A., Kastelein J. J. P. Cholesteryl ester transfer protein concentration is associated with progression of atherosclerosis and response to pravastatin in men with coronary artery disease (REGRESS) European journal of clinical investigation 2004;34 (1):21-28 [PubMed]
• van Aalst-Cohen Emily S., Jansen Angelique C. M., de Jongh Saskia, de Sauvage Nolting Pernette R. W., Kastelein John J. P. Clinical, diagnostic, and therapeutic aspects of familial hypercholesterolemia Seminars in vascular medicine 2004;4 (1):31-41 [PubMed]
• van Aalst-Cohen E. S., Trip M. D., Vissers M. N., Rodenburg J., Kastelein J. J. P. Clinical, diagnostic and therapeutic aspects of (inherited) hypercholesterolemia Drug discovery today 2004;1 (2):165-170
• Wonderling David, Umans-Eckenhausen Marina A. W., Marks Dalya, Defesche Joep C., Kastelein John J. P., Thorogood Margaret Cost-effectiveness analysis of the genetic screening program for familial hypercholesterolemia in the Netherlands Seminars in vascular medicine 2004;4 (1):97-104 [PubMed]
• Pedersen Terje R., Faergeman Ole, Kastelein John J. P., Olsson Anders G., Tikkanen Matti J., Holme Ingar, Larsen Mogens Lytken, Bendiksen Fredrik S., Lindahl Christina, Palmer Gary Design and baseline characteristics of the incremental decrease in end points through aggressive lipid lowering study American journal of cardiology 2004;94 (6):720-724 [PubMed]
• Maitland-van der Zee Anke-Hilse, Stricker Bruno H. Ch, Klungel Olaf H., Kastelein John J. P., Hofman Albert, Witteman Jacqueline C. M., Leufkens Hubertus G. M., van Duijn Cornelia M., de Boer Anthonius Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism Atherosclerosis 2004;175 (2):377-379 [PubMed]
• van Tits Lambertus J. H., Smilde Tineke J., van Wissen Sanne, de Graaf Jacqueline, Kastelein John J. P., Stalenhoef Anton F. H. Effects of atorvastatin and simvastatin on low-density lipoprotein subfraction profile, low-density lipoprotein oxidizability, and antibodies to oxidized low-density lipoprotein in relation to carotid intima media thickness in familial hypercholesterolemia Journal of investigative medicine 2004;52 (3):177-184 [PubMed]
• Wiegman Albert, Hutten Barbara A., de Groot Eric, Rodenburg Jessica, Bakker Henk D., Büller Harry R., Sijbrands Eric J. G., Kastelein John J. P. Efficacy and safety of statin therapy in children with familial hypercholesterolemia - A randomized controlled trial JAMA 2004;292 (3):331-337 [PubMed]
• Jukema J. W., Lenselink M., de Grooth G. J., Boekholdt S. M., Liem A. H., Kuivenhoven J. A., Kastelein J. J. P. Enhancing reverse cholesterol transport/raising HDL cholesterol: new options for prevention and treatment of cardiovascular disease Netherlands heart journal 2004;12 (11):491-508
• Fouchier Sigrid W., Defesche Joep C., Kastelein John J. P., Sijbrands Eric J. G. Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk Seminars in vascular medicine 2004;4 (3):259-264 [PubMed]
• van Bellen A., Defesche J. C., Kastelein J. J. P., Wiegman A. Familial hypercholesterolemiain: Y. Poortman, R. Steegers, C. Kluft, editors. The increasing role of nutrition and genomics in the prevention and management of disease. S.l.: s.n.; 2004. p. hfst 6
• Rodenburg J., Vissers M. N., Wiegman A., Trip M. D., Bakker H. D., Kastelein John J. P. Familial hypercholesterolemia in children Current opinion in lipidology 2004;15 (4):405-411 [PubMed]
• Hovingh G. K., Kuivenhoven J. A., Bisoendial R. J., Groen A. K., van Dam M., van Tol A., Wellington C., Hayden M. R., Smelt A. H. M., Kastelein J. J. P. HDL deficiency and atherosclerosis: lessons from Tangier disease Journal of internal medicine 2004;255 (2):299-301 [PubMed]
• Birjmohun R. S., Hutten B. A., Kastelein J. J. P., Stroes E. S. G. Increasing HDL cholesterol with extended-release nicotinic acid: from promise to practice Netherlands journal of medicine 2004;62 (7):229-234 [PubMed]
• Boekholdt S. Matthijs, Peters Ron J. G., de Maat Moniek P. M., Zwinderman Aeilko H., van der Wall Ernst E., Reitsma Pieter H., Jukema J. Wouter, Kastelein John J. P. Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events American heart journal 2004;147 (1):181-186 [PubMed]
• Rodenburg Jessica, Vissers Maud N., Daniels Stephen R., Wiegman Albert, Kastelein John J. P. Lipid-lowering medications Pediatric endocrinology reviews 2004;2 (Suppl. 1):171-180 [PubMed]
• Rotmans Joris I., Verhagen Hence J. M., Velema Evelyn, de kleijn Dominique P. V., van den Heuvel Mieke, Kastelein John J. P., Pasterkamp Gerard, Stroes Erik S. G. Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts Kidney international 2004;65 (5):1897-1905 [PubMed]
• Ross Colin J. D., Twisk Jaap, Meulenberg Janneke M., Liu Guoqing, van den Oever Karin, Moraal Ewoud, Hermens Wim T., Rip Jaap, Kastelein John J. P., Kuivenhoven Jan Albert, Hayden Michael R. Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPLS447X beneficial mutation Human gene therapy 2004;15 (9):906-919 [PubMed]
• de Groot Eric, Hovingh G. Kees, Wiegman Albert, Duriez Patrick, Smit Andries J., Fruchart Jean-Charles, Kastelein John J. P. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis Circulation 2004;109 (23 Suppl 1):III33-III38 [PubMed]
• van Leth Frank, Phanuphak Prahpan, Stroes Erik, Gazzard Brian, Cahn Pedro, Raffi François, Wood Robin, Bloch Mark, Katlama Christine, Kastelein John J. P., Schechter Mauro, Murphy Robert L., Horban Andrzej, Hall David B., Lange Joep M. A., Reiss Peter Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1 PLoS medicine 2004;1 (1):e19-74 [PubMed]
• Fruchart Jean-Charles, Nierman Melchior C., Stroes Erik S. G., Kastelein John J. P., Duriez Patrick New risk factors for atherosclerosis and patient risk assessment Circulation 2004;109 (23 Suppl 1):III15-III19 [PubMed]
• Maitland-van der Zee Anke Hilse, Klungel Olaf H., Stricker Bruno H. Ch, Veenstra David L., Kastelein John J. P., Hofman Albert, Witteman Jacqueline C. M., Leufkens Hubertus G. M., van Duijn Cornelia M., de Boer Anthonius Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men Pharmacogenetics 2004;14 (1):53-60 [PubMed]
• Agema Willem R. P., Jukema J. Wouter, de Maat Moniek P. M., Zwinderman Aeilko H., Kastelein John J. P., Rabelink Ton J., van der Wall Ernst E. Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis Thrombosis and haemostasis 2004;91 (5):986-990 [PubMed]
• Boekholdt S. Matthijs, Kuivenhoven Jan-Albert, Wareham Nicholas J., Peters Ron J. G., Jukema J. Wouter, Luben Robert, Bingham Sheila A., Day Nicholas E., Kastelein John J. P., Khaw Kay-Tee Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study Circulation 2004;110 (11):1418-1423 [PubMed]
• Kastelein J. Polymorphisms, practicalities and pleiotropism International journal of clinical practice 2004;58 (Suppl. 143):1-2
• Foucher Christelle, Rattier Stephanie, Flavell David M., Talmud Philippa J., Humphries Steve E., Kastelein John J. P., Ayyobi Amir, Pimstone Simon, Frohlich Jiri, Ansquer Jean-Claude, Steiner George Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes Pharmacogenetics 2004;14 (12):823-829 [PubMed]
• van der Steeg W. A., Kuivenhoven J. A., Klerkx A. H., Boekholdt S. M., Hovingh G. K., Kastelein J. J. P. Role of CETP inhibitors in the treatment of dyslipidemia Current opinion in lipidology 2004;15 (6):631-636 [PubMed]
• Shepherd James, Hunninghake Donald B., Stein Evan A., Kastelein John J. P., Harris Susan, Pears John, Hutchinson Howard G. Safety of rosuvastatin American journal of cardiology 2004;94 (7):882-888 [PubMed]
• Kastelein John J. P. Should rosuvastatin be withdrawn from the market? Lancet 2004;364 (9445):1577-8; author reply 1578-9 [PubMed]
• Wiersma Heleen E., Wiegman Albert, Koopmans Richard P., Bakker Henk D., Kastelein John J. P., van Boxtel Chris J. Steady-state pharmacokinetics of pravastatin in children with familial hypercholesterolaemia Clinical drug investigation 2004;24 (2):113-120 [PubMed]
• Kastelein John J. P., Stroes Erik S. G., de Groot Eric Subclinical atherosclerosis as a target of therapy: Potential role of statins American journal of cardiology 2004;93 (6):737-740 [PubMed]
• de Grooth Greetje J., Zerba Kim E., Huang Shu-Pang, Tsuchihashi Zenta, Kirchgessner Todd, Belder René, Vishnupad Priya, Hu Beihong, Klerkx Anke H. E. M., Zwinderman Aeilko H., Jukema J. Wouter, Sacks Frank M., Kastelein John J. P., Kuivenhoven Jan Albert The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: No interaction with the response to pravastatin therapy and no effects on cardiovascular outcome - A prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy Journal of the American College of Cardiology 2004;43 (5):854-857 [PubMed]
• Jansen A. C. M., van Aalst-Cohen E. S., Tanck M. W., Trip M. D., Lansberg P. J., Liem A. H., van Lennep H. W. O. Roeters, Sijbrands E. J. G., Kastelein J. J. P. The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients Journal of internal medicine 2004;256 (6):482-490 [PubMed]
• de Grooth Greetje J., Smilde Tineke J., van Wissen Sanne, Klerkx Anke H. E. M., Zwinderman Aeilko H., Fruchart Jean-Charles, Kastelein John J. P., Stalenhoef Anton F. H., Kuivenhoven Jan Albert The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia Atherosclerosis 2004;173 (2):261-267 [PubMed]
• Rodenburg J., Vissers M. N., Trip M. D., Wiegman A., Bakker H. D., Kastelein J. J. P. The spectrum of statin therapy in hyperlipidemic children Seminars in vascular medicine 2004;4 (4):313-320 [PubMed]
• Netea M. G., Hijmans A., van Wissen S., Smilde T. J., Trip M. D., Kullberg B. J., de Boo T., van der Meer J. W. M., Kastelein J. J. P., Stalenhoef A. F. H., Stalenhorf A. F. H. Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia European journal of clinical investigation 2004;34 (2):94-99 [PubMed]
• Büller H. R., Kastelein J. J. P., Stroes E. S. G. Vasculaire geneeskundeAlphen a/d Rijn: Van Zuiden; 2004.
• Büller H. R., Kastelein J. J. P., Stroes E. S. G. Vasculaire geneeskundeAlphen a/d Rijn: Van Zuiden; 2004.

2003

• Maitland-van der Zee Anke-Hilse, Stricker Bruno H. Ch, Klungel Olaf H., Mantel-Teeuwisse Aukje K., Kastelein John J. P., Hofman Albert, Leufkens Hubertus G. M., van Duijn Cornelia M., de Boer Anthonius Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes Pharmacogenetics 2003;13 (4):219-223 [PubMed]
• van Wissen S. Aggressive lipid lowering in patients with familial hypercholesterolaemia 2003. 150p. ISBN 9789051706901. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Stalenhoef A. F. H.; Co-supervisor: Büller H. R.)
• Hoogendijk C. F., Scholtz C. L., Pimstone S. M., Ehrenborg E., Kastelein J. J. P., Defesche J. C., Thiart R., du Plessis L., de Villiers J. N. P., Zaahl M. G., Delport R., Rubinsztein D. C., Raffel L. J., Grim C. E., Mediene-Benchekor S., Amouyel P., Brousseau T., Steyn K., Lombard C. J., Hayden M. R., Kotze M. J. Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element Molecular and cellular probes 2003;17 (4):175-181 [PubMed]
• Elrayess Mohamed A., Webb Karen E., Flavell David M., Syvänne Mikko, Taskinen Marja-Riitta, Frick M. Heikki, Nieminen Markku S., Kesäniemi Y. Antero, Pasternack Amos, Jukema J. Wouter, Kastelein John J. P., Zwinderman Aeilko H., Humphries Steve E. A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies Atherosclerosis 2003;168 (1):131-138 [PubMed]
• Nanjee M. Nazeem, Stocks Joseph, Cooke C. Justin, Molhuizen Henri O. F., Marcovina Santica, Crook David, Kastelein John P., Miller Norman E. A novel LCAT mutation (Phe382-->Val) in a kindred with familial LCAT deficiency and defective apolipoprotein B-100 Atherosclerosis 2003;170 (1):105-113 [PubMed]
• Ozsoy R. C., Kastelein J. J. P., Arisz L., Koopman M. G. Atorvastatin and the dyslipidemia of early renal failure Atherosclerosis 2003;166 (1):187-194 [PubMed]
• de Grooth G. J. Cholesteryl ester transfer protein. Its role in cardiovascular disease and drug development 2003. 166p. ISBN 9789074384032. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Stalenhoef A. F. H., Kuivenhoven J. A.)
• Trip Mieke D., van Wissen Sanne, Smilde Tineke J., Hutten Barbara A., Stalenhoef Anton F. H., Kastelein John J. P. Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia American journal of cardiology 2003;91 (5):604-606 [PubMed]
• Singaraja Roshni R., Brunham Liam R., Visscher Henk, Kastelein John J. P., Hayden Michael R. Efflux and atherosclerosis - The clinical and biochemical impact of variations in the ABCA1 gene Arteriosclerosis, thrombosis, and vascular biology 2003;23 (8):1322-1332 [PubMed]
• Tanck M. W. T., Klerkx A. H. E. M., Jukema J. W., de Knijff P., Kastelein J. J. P., Zwinderman A. H. Estimation of multilocus haplotype effects using weighted penalised log-likelihood: Analysis of five sequence variations at the cholesteryl ester transfer protein gene locus Annals of human genetics 2003;67 (Part 2):175-184 [PubMed]
• Jansen A. C. M. Familial hypercholesterolemia. The determination of phenotype 2003. 167p. ISBN 9789090175430. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Sijbrands E. J. G., Tanck M. W. T.)
• Wiegman Albert, Rodenburg Jessica, de Jongh Saskia, Defesche Joep C., Bakker Henk D., Kastelein John J. P., Sijbrands Eric J. G. Family history and cardiovascular risk in familial hypercholesterolemia - Data in more than 1000 children Circulation 2003;107 (11):1473-1478 [PubMed]
• Klerkx Anke H. E. M., Tanck Michael W. T., Kastelein John J. P., Molhuizen Henri O. F., Jukema J. Wouter, Zwinderman Aeilko H., Kuivenhoven Jan Albert Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration Human molecular genetics 2003;12 (2):111-123 [PubMed]
• Kuivenhoven J. A., Hovingh G. K., van Tol A., Jauhiainen M., Ehnholm C., Fruchart J. C., Brinton E. A., Otvos J. D., Smelt A. H. M., Brownlee A., Zwinderman A. H., Hayden M. R., Kastelein J. J. P. Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size Atherosclerosis 2003;171 (2):311-319 [PubMed]
• Barter Philip, Kastelein John, Nunn Alistair, Hobbs Richard High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions Atherosclerosis 2003;168 (2):195-211 [PubMed]
• van der Valk M., Sauerwein H. P., Kastelein J. J. P., Reiss P. Lipodystrophy associated with treatment of HIV-1 infection Adverse drug reaction bulletin 2003;218:835-838
• Umans-Eckenhausen Marina A. W., Defesche Joep C., van Dam Marjel J., Kastelein John J. P. Long-term compliance with lipid-lowering medication after genetic screening for familial hypercholesterolemia Archives of internal medicine 2003;163 (1):65-68 [PubMed]
• van Wissen S., Smilde T. J., Trip M. D., de Boo Th, Kastelein J. J. P., Stalenhoef A. F. H. Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia Heart (British Cardiac Society) 2003;89 (8):893-896 [PubMed]
• Boekholdt S. Matthijs, Peters Ron J. G., Fountoulaki Katerina, Kastelein John J. P., Sijbrands Eric J. G. Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis Human genetics 2003;113 (5):417-425 [PubMed]
• Wiegman A. Pediatric implications of heterozygous familial hypercholesterolemia 2003. 147p. ISBN 9789090170428. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Heymans H. S. A.; Co-supervisors: Bakker H. D., Sijbrands E. J. G.)
• de Jongh S., Vissers M. N., Rol P., Bakker H. D., Kastelein J. J. P., Stroes E. S. G. Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia Journal of inherited metabolic disease 2003;26 (4):343-351 [PubMed]
• de Sauvage Nolting P. R. W., Defesche J. C., Buirma R. J. A., Hutten B. A., Lansberg P. J., Kastelein J. J. P. Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia Journal of internal medicine 2003;253 (2):161-168 [PubMed]
• Semb Anne G., van Wissen Sanne, Ueland Thor, Smilde Tineke, Waehre Torgun, Tripp Mieke D., Frøland Stig S., Kastelein John J. P., Gullestad Lars, Pedersen Terje R., Aukrust Pål, Stalenhoef Anton F. H. Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: Downregulatory effect of statin therapy Journal of the American College of Cardiology 2003;41 (2):275-279 [PubMed]
• Rotmans J. I., Velema E., Verhagen H. J. M., Blankensteijn J. D., Kastelein J. J. P., de Kleijn D. P. V., Yo M., Pasterkamp G., Stroes E. S. G. Rapid, arteriovenous graft failure due to intimal hyperplasia: A porcine, bilateral, carotid arteriovenous graft model Journal of surgical research 2003;113 (1):161-171 [PubMed]
• Nolting Pernette R. W. de Sauvage, de Groot Eric, Zwinderman Aeilko H., Buirma Rudolf J. A., Trip Mieke D., Kastelein John J. P. Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: Treatment with simvastatin Archives of internal medicine 2003;163 (15):1837-1841 [PubMed]
• Bisoendial Radjesh J., Hovingh G. Kees, Levels Johannes H. M., Lerch Peter G., Andresen Irmgard, Hayden Michael R., Kastelein John J. P., Stroes Erik S. G. Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein Circulation 2003;107 (23):2944-2948 [PubMed]
• Descamps Olivier S., de Meester Antoine, Cheron Paul, Kastelein John J., Heller Francis R. Silent ischaemia in familial hypercholesterolemia Atherosclerosis. Supplements 2003;4 (3):7-8 [PubMed]
• Kastelein John J. P., Wiegman Albert, de Groot Eric Surrogate markers of atherosclerosis: impact of statins Atherosclerosis. Supplements 2003;4 (1):31-36 [PubMed]
• Wiegman Albert, Sijbrands Eric J. G., Rodenburg Jessica, Defesche Joep C., de Jongh Saskia, Bakker Henk D., Kastelein John J. P. The apolipoprotein epsilon4 allele confers additional risk in children with familial hypercholesterolemia Pediatric research 2003;53 (6):1008-1012 [PubMed]
• Kastelein J. J. P. The future of lipid-lowering therapy: the big picture Netherlands journal of medicine 2003;61 (5 Suppl):35-39 [PubMed]
• van Vugt R. M., Kater L., Dijkstra P. F., Schardijn G. H., Kastelein J. J., Bijlsma J. W. The outcome of angiography in patients with Raynaud's phenomenon: an unexpected role for atherosclerosis and hypercholesterolemia Clinical and experimental rheumatology 2003;21 (4):445-450 [PubMed]
• Singaraja R. R. The role of abca1 in athrosclerosis: lessons from in vitro and in vivo models 2003. 239p. ISBN 9789090172286. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Hayden M. R.)
• Hovingh G. Kees, van Wijland Michel J. A., Brownlie Alison, Bisoendial Radjesh J., Hayden Michael R., Kastelein John J. P., Groen Albert K. The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia Journal of lipid research 2003;44 (6):1251-1255 [PubMed]
• van Wissen Sanne, Smilde Tineke J., de Groot Eric, Hutten Barbara A., Kastelein John J. P., Stalenhoef Anton F. H. The significance of femoral intima-media thickness and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study Journal of cardiovascular risk 2003;10 (6):451-455 [PubMed]
• Boekholdt S. Matthijs, Agema Willem R. P., Peters Ron J. G., Zwinderman Aeilko H., van der Wall Ernst E., Reitsma Pieter H., Kastelein John J. P., Jukema J. Wouter Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events Circulation 2003;107 (19):2416-2421 [PubMed]
• Kastelein John What future for combination therapies? International journal of clinical practice 2003;134 (134):45-50 [PubMed]

2002

• Zwarts K. Y., Clee S. M., Zwinderman A. H., Engert J. C., Singaraja R., Loubser O., James E., Roomp K., Hudson T. J., Jukema J. W., Kastelein J. J. P., Hayden M. R. ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels Clinical genetics 2002;61 (2):115-125 [PubMed]
• Kastelein J., de Groot E., Zwinderman K. Arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux - Reply Lancet 2002;359 (9325):2279
• van Dam Marjel J., de Groot Eric, Clee Susanne M., Hovingh G. Kees, Roelants Roosje, Brooks-Wilson Angie, Zwinderman Aeilko H., Smit Andries J., Smelt August H. M., Groen Albert K., Hayden Michael R., Kastelein John J. P. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study Lancet 2002;359 (9300):37-41 [PubMed]
• de Sauvage Nolting Pernette R. W., Buirma Rudolf J. A., Hutten Barbara A., Kastelein John J. P. Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial hypercholesterolemia - The examination of probands and relatives in Statin studies with familial hypercholesterolemia (ExPRESS FH) Atherosclerosis 2002;164 (2):347-354 [PubMed]
• de Graaf Jacqueline, de Sauvage Nolting Pernette R. W., van Dam Marjel, Belsey Elizabeth M., Kastelein John J. P., Haydn Pritchard P., Stalenhoef Anton F. H. Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels British journal of nutrition 2002;88 (5):479-488 [PubMed]
• van Dam Marjel, van Wissen Sanne, Kastelein John J. P. Declaring war on undertreatment: rationale for an aggressive approach to lowering cholesterol Journal of cardiovascular risk 2002;9 (2):89-95 [PubMed]
• van Wissen Sanne, Trip Mieke D., Smilde Tineke J., de Graaf Jacqueline, Stalenhoef Anton F. H., Kastelein John J. P. Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy Atherosclerosis 2002;165 (2):361-366 [PubMed]
• de Jongh Saskia, Lilien Marc R., Op't Roodt Jos, Stroes Erik S. G., Bakker Henk D., Kastelein John J. P. Early statin therapy restores endothelial function in children with familial hypercholesterolemia Journal of the American College of Cardiology 2002;40 (12):2117-2121 [PubMed]
• de Grooth Greetje J., Kuivenhoven Jan Albert, Stalenhoef Anton F. H., de Graaf Jacqueline, Zwinderman Aeilko H., Posma Jan L., van Tol Arie, Kastelein John J. P. Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans - A randomized phase II dose-response study Circulation 2002;105 (18):2159-2165 [PubMed]
• de Jongh Saskia, Ose Leiv, Szamosi Tamás, Gagné Claude, Lambert M., Scott Russell, Perron P., Dobbelaere Dries, Saborio M., Tuohy Mary B., Stepanavage Michael, Sapre Aditi, Gumbiner Barry, Mercuri Michele, van Trotsenburg A. S. Paul, Bakker Henk D., Kastelein John J. P. Efficacy and safety of statin therapy in children with familial hypercholesterolemia - A randomized, double-blind, placebo-controlled trial with simvastatin Circulation 2002;106 (17):2231-2237 [PubMed]
• de Jongh S., Stalenhoef A. F. H., Tuohy M. B., Mercuri M., Bakker H. D., Kastelein J. J. P. Efficacy, safety and tolerability of simvastatin in children with familial hypercholesterolaemia - Rationale, design and baseline characteristics Clinical drug investigation 2002;22 (8):533-540
• de Sauvage Nolting Pernette R. W., Twickler Marcel B., Dallinga-Thie Geesje M., Buirma Rudolf J. A., Hutten Barbara A., Kastelein John J. P. Elevated remnant-like particles in heterozygous familial hypercholesterolemia and response to statin therapy Circulation 2002;106 (7):788-792 [PubMed]
• de Beer Femke, Stalenhoef Anton F. H., Hoogerbrugge Nicoline, Kastelein John J. P., Gevers Leuven Jan A., van Duijn Cornelia M., Havekes Louis M., Smelt Augustinus H. M. Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 -> Cys) homozygotes is associated with hyperinsulinemia Arteriosclerosis, thrombosis, and vascular biology 2002;22 (2):294-299 [PubMed]
• de Jongh S. Familial hypercholesterolemia in childhood 2002. 159p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Heymans H. S. A.; Co-supervisors: Bakker H. D., Büller H. R.)
• de Jongh Saskia, Lilien Marc R., Bakker Henk D., Hutten Barbara A., Kastelein John J. P., Stroes Erik S. G. Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia Atherosclerosis 2002;163 (1):193-197 [PubMed]
• Trip Mieke D., Smulders Yvo M., Wegman Jurgen J., Hu Xiaofeng, Boer Jolanda M. A., ten Brink Jacoline B., Zwinderman Aeilko H., Kastelein John J. P., Feskens Edith J. M., Bergen Arthur A. B. Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease Circulation 2002;106 (7):773-775 [PubMed]
• Umans-Eckenhausen M. A. W. Genetic insights, clinical efficacy and practical implications of genetic screening for familial hypercholesterolemia 2002. 165p. ISBN 9789051706574. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Büller H. R., Kastelein J. J. P.; Co-supervisor: Defesche J. C.)
• Maitland-van der Zee Anke Hilse, Klungel Olaf H., Stricker Bruno H. Ch, Verschuren W. M. Monique, Kastelein John J. P., Leufkens Hubertus G. M., de Boer Anthonius Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors Atherosclerosis 2002;163 (2):213-222 [PubMed]
• de Sauvage Nolting P. R. W. Genetics and therapy of familial hypercholesterolemia 2002. 173p. ISBN 9789064640858. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kastelein J. J. P., Büller H. R.)
• Attie Alan D., Hamon Yannick, Brooks-Wilson Angela R., Gray-Keller Mark P., MacDonald Marcia L. E., Rigot Veronique, Tebon Angie, Zhang Lin-Hua, Mulligan Jacob D., Singaraja Roshni R., Bitgood J. James, Cook Mark E., Kastelein John J. P., Chimini Giovanna, Hayden Michael R. Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken Journal of lipid research 2002;43 (10):1610-1617 [PubMed]
• Evans Valerie, Kastelein John J. P. Lipoprotein lipase deficiency - Rare or common? Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2002;16 (4):283-287 [PubMed]
• van Dam M., Zwart M., de Beer F., Smelt A. H. M., Prins M. H., Trip M. D., Havekes L. M., Lansberg P. J., Kastelein J. J. P. Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia Heart (British Cardiac Society) 2002;88 (3):234-238 [PubMed]
• Umans-Eckenhausen Marina A. W., Sijbrands Eric J. G., Kastelein John J. P., Defesche Joep C. Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population Circulation 2002;106 (24):3031-3036 [PubMed]
• Bisoendial Radjesh J., Hovingh G. Kees, de Groot Eric, Kastelein John J. P., Lansberg Peter J., Stroes Erik S. G. Measurement of subclinical atherosclerosis: beyond risk factor assessment Current opinion in lipidology 2002;13 (6):595-603 [PubMed]
• Umans-Eckenhausen M. A. W., Oort F. J., Ferenschild K. C. M. P., Defesche J. C., Kastelein J. J. P., de Haes J. C. J. M. Parental attitude towards genetic testing for familial hypercholesterolaemia in children Journal of medical genetics 2002;39 (9):e49 [PubMed]
• Jansen Angelique C. M., van Wissen Sanne, Defesche Joep C., Kastelein John J. P. Phenotypic variability in familial hypercholesterolaemia: an update Current opinion in lipidology 2002;13 (2):165-171 [PubMed]
• Attie Alan D., Krauss Ronald M., Gray-Keller Mark P., Brownlie Alison, Miyazaki Makoto, Kastelein John J., Lusis Aldons J., Stalenhoef Anton F. H., Stoehr Jonathan P., Hayden Michael R., Ntambi James M. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia Journal of lipid research 2002;43 (11):1899-1907 [PubMed]
• Maitland-van der Zee Anke-Hilse, Stricker Bruno H., Klungel Olaf H., Kastelein John J., Hofman Albert, Witteman Jacqueline C., Breteler Monique M., Leufkens Hubertus G., van Duijn Cornelia M., de Boer Anthonius The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype Pharmacogenetics 2002;12 (8):647-653 [PubMed]
• Trip M. D. The spectrum of premature atherosclerosis: from single gene to complex genetic disorder 2002. 248p. ISBN 9789090164601. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Kastelein J. J. P.; Co-supervisors: Büller H. R., Reitsma P. H.)
• Boekholdt S. Matthijs, Trip Mieke D., Peters Ron J. G., Engelen Marc, Boer Jolanda M. A., Feskens Edith J. M., Zwinderman Aeilko H., Kastelein John J. P., Reitsma Pieter H. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction Arteriosclerosis, thrombosis, and vascular biology 2002;22 (12):E24-E27 [PubMed]
• van Dam M. J., Kastelein J. J. P. Treatment of hyperlipidemia with the statins: redefining what the statins can do Cardiovascular reviews and reports 2002;23:77-81, 84
• Wellington Cheryl L., Yang Yu-Zhou, Zhou Stephen, Clee Susanne M., Tan Bing, Hirano Kenichi, Zwarts Karin, Kwok Anita, Gelfer Allison, Marcil Michel, Newman Scott, Roomp Kirsten, Singaraja Roshni, Collins Jennifer, Zhang Lin-Hua, Groen Albert K., Hovingh Kees, Brownlie Alison, Tafuri Sherrie, Genest Jacques, Kastelein John J. P., Hayden Michael R. Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol Journal of lipid research 2002;43 (11):1939-1949 [PubMed]
• de Sauvage Nolting Pernette R. W., Buirma Rudolf J. A., Hutten Barbara A., Kastelein John J. P. Two-year efficacy and safety of Simvastatin 80 mg in familial hypercholesterolemia (The examination of probands and relatives in statin studies with familial hypercholesterolemia [ExPRESS FH]) American journal of cardiology 2002;90 (2):181-+ [PubMed]
• Büller H. R., Kastelein J. J. P., Stroes E. S. G. Vasculaire geneeskundeAlphen a/d Rijn: Van Zuiden Communications; 2002. ISBN 9789076906348

2001

• van Dam M. J., Penn H. J., den Hartog F. R., Kragten H. A., Trip M. D., Buirma R. J., Kastelein J. J. A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: a randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease Clinical therapeutics 2001;23 (3):467-478 [PubMed]
• Clee S. M., Zwinderman A. H., Engert J. C., Zwarts K. Y., Molhuizen H. O., Roomp K., Jukema J. W., van Wijland M., van Dam M., Hudson T. J., Brooks-Wilson A., Genest J., Kastelein J. J., Hayden M. R. Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease Circulation 2001;103 (9):1198-1205 [PubMed]
• Smilde T. J., van Wissen S., Wollersheim H., Trip M. D., Kastelein J. J., Stalenhoef A. F. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial Lancet 2001;357 (9256):577-581 [PubMed]
• Smilde T. J., van Wissen S., Wollersheim H., Kastelein J. J., Stalenhoef A. F. Genetic and metabolic factors predicting risk of cardiovascular disease in familial hypercholesterolemia Netherlands journal of medicine 2001;59 (4):184-195 [PubMed]
• Agema W. R., Jukema J. W., Pimstone S. N., Kastelein J. J. Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy European heart journal 2001;22 (22):2058-2074 [PubMed]
• van Geel P. P., Pinto Y. M., Zwinderman A. H., Henning R. H., van Boven A. J., Jukema J. W., Bruschke A. V., Kastelein J. J., van Gilst W. H. Increased risk for ischaemic events is related to combined RAS polymorphism Heart (British Cardiac Society) 2001;85 (4):458-462 [PubMed]
• Defesche J. C., Kastelein J. J. P. Lipoproteins and atherosclerosisin: P. A. Doevendans, A. A. Wilde, editors. Cardiovascular genetics. Dordrecht: Kluwer Academic Publishers; 2001. p. 51-58
• Doevendans P. A., Jukema W., Spiering W., Defesche J. C., Kastelein J. J. Molecular genetics and gene expression in atherosclerosis International journal of cardiology 2001;80 (2-3):161-172 [PubMed]
• Sijbrands E. J., Westendorp R. G., Defesche J. C., de Meier P. H., Smelt A. H., Kastelein J. J. Mortality over two centuries in large pedigree with familial hypercholesterolaemia: family tree mortality study BMJ (Clinical research ed.) 2001;322 (7293):1019-1023 [PubMed]
• van der Valk M., Kastelein J. J., Murphy R. L., van Leth F., Katlama C., Horban A., Glesby M., Behrens G., Clotet B., Stellato R. K., Molhuizen H. O., Reiss P. Nevirapine-containing antiretroviral therapy in HIV-1 infected patients results in an anti-atherogenic lipid profile AIDS (London, England) 2001;15 (18):2407-2414 [PubMed]
• Boer J. M., Feskens E. J., Kuivenhoven J. A., Schouten E. G., Havekes L. M., Kastelein J. J., Seidell J. C., Kromhout D. Parental history of myocardial infarction: lipid traits, gene polymorphisms and lifestyle Atherosclerosis 2001;155 (1):149-156 [PubMed]
• Attie A. D., Kastelein J. P., Hayden M. R. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis Journal of lipid research 2001;42 (11):1717-1726 [PubMed]
• Leus F. R., Zwart M., Kastelein J. J., Voorbij H. A. PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients Atherosclerosis 2001;154 (3):641-649 [PubMed]
• ten Asbroek A. H., de Mheen P. J., Defesche J. C., Kastelein J. J., Gunning-Schepers L. J. Results from a family and DNA based active identification programme for familial hypercholesterolaemia Journal of epidemiology and community health 2001;55 (7):500-502 [PubMed]
• Umans-Eckenhausen M. A., Defesche J. C., Sijbrands E. J., Scheerder R. L., Kastelein J. J. Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands Lancet 2001;357 (9251):165-168 [PubMed]
• Clee S. M., Loubser O., Collins J., Kastelein J. J., Hayden M. R. The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease Clinical genetics 2001;60 (4):293-300 [PubMed]
• Fouchier S. W., Defesche J. C., Umans-Eckenhausen M. W., Kastelein J. P. The molecular basis of familial hypercholesterolemia in The Netherlands Human genetics 2001;109 (6):602-615 [PubMed]

2000

• Sijbrands E. J., Westendorp R. G., Paola Lombardi M., Havekes L. M., Frants R. R., Kastelein J. J., Smelt A. H. Additional risk factors influence excess mortality in heterozygous familial hypercholesterolaemia Atherosclerosis 2000;149 (2):421-425 [PubMed]
• Clee S. M., Kastelein J. J., van Dam M., Marcil M., Roomp K., Zwarts K. Y., Collins J. A., Roelants R., Tamasawa N., Stulc T., Suda T., Ceska R., Boucher B., Rondeau C., DeSouich C., Brooks-Wilson A., Molhuizen H. O., Frohlich J., Genest J., Hayden M. R. Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes Journal of clinical investigation 2000;106 (10):1263-1270 [PubMed]
• Hayden M. R., Clee S. M., Brooks-Wilson A., Genest J., Attie A., Kastelein J. J. Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency Current opinion in lipidology 2000;11 (2):117-122 [PubMed]
• Kastelein J. J., Isaacsohn J. L., Ose L., Hunninghake D. B., Frohlich J., Davidson M. H., Habib R., Dujovne C. A., Crouse J. R., Liu M., Melino M. R., O'Grady L., Mercuri M., Mitchel Y. B. Comparison of effects of simvastatin versus atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I levels American journal of cardiology 2000;86 (2):221-223 [PubMed]
• Trip M. D., Lansberg P. J., de Jongh S., Kastelein J. J. Familiaire hypercholesterolemie: cardiovasculaire complicaties op jonge leeftijd te verwachten en te voorkomen Nederlands tijdschrift voor geneeskunde 2000;144 (30):1425-1428 [PubMed]
• Ose L., Davidson M. H., Stein E. A., Kastelein J. J., Scott R. S., Hunninghake D. B., Campodonico S., Insull W., Escobar I. D., Schrott H. G., Stepanavage M. E., Wu M., Tate A. C., Melino M. R., Mercuri M., Mitchel Y. B. Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group Clinical cardiology 2000;23 (1):39-46 [PubMed]
• Davidson M. H., Stein E. A., Hunninghake D. B., Ose L., Dujovne C. A., Insull W., Bertolami M., Weiss S. R., Kastelein J. J., Scott R. S., Campodónico S., Escobar I. D., Schrott H. G., Bays H., Stepanavage M. E., Wu M., Tate A. C., Melino M. R., Kush D., Mercuri M., Mitchel Y. B. Lipid-altering efficacy and safety of simvastatin 80 mg/day: worldwide long-term experience in patients with hypercholesterolemia Nutrition, metabolism, and cardiovascular diseases 2000;10 (5):253-262 [PubMed]
• Kastelein J. J., Jukema J. W., Zwinderman A. H., Clee S., van Boven A. J., Jansen H., Rabelink T. J., Peters R. J., Lie K. I., Liu G., Bruschke A. V., Hayden M. R. Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group Circulation 2000;102 (14):1629-1633 [PubMed]
• Heikens J., Ubbink M. C., van der Pal H. P., Bakker P. J., Fliers E., Smilde T. J., Kastelein J. J., Trip M. D. Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease Cancer 2000;88 (9):2116-2121 [PubMed]
• Khoo K. L., van Acker P., Defesche J. C., Tan H., van de Kerkhof L., Heijnen-van Eijk S. J., Kastelein J. J., Deslypere J. P. Low-density lipoprotein receptor gene mutations in a Southeast Asian population with familial hypercholesterolemia Clinical genetics 2000;58 (2):98-105 [PubMed]
• Lombardi M. P., Redeker E. J., Defesche J. C., Kamerling S. W., Trip M. D., Mannens M. M., Havekes L. M., Kastelein J. J. Molecular genetic testing for familial hypercholesterolemia: spectrum of LDL receptor gene mutations in The Netherlands Clinical genetics 2000;57 (2):116-124 [PubMed]
• Leus F. R., Wittekoek M. E., Prins J., Kastelein J. J., Voorbij H. A. Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia Atherosclerosis 2000;149 (2):371-377 [PubMed]
• Clee S. M., Bissada N., Miao F., Miao L., Marais A. D., Henderson H. E., Steures P., McManus J., McManus B., LeBoeuf R. C., Kastelein J. J., Hayden M. R. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis Journal of lipid research 2000;41 (4):521-531 [PubMed]
• Lansberg P. J., Tuzgöl S., van de Ree M. A., Defesche J. C., Kastelein J. J. Prevalentie van familiaire hypercholesterolemie onder volwassenen in vier huisartsenpraktijken hoger dan werd aangenomen Nederlands tijdschrift voor geneeskunde 2000;144 (30):1437-1440 [PubMed]
• Smilde T. J., Trip M. D., Wollersheim H., van Wissen S., Kastelein J. J., Stalenhoef A. F. Rationale, Design and Baseline Characteristics of a Clinical Trial Comparing the Effects of Robust vs Conventional Cholesterol Lowering and Intima Media Thickness in Patients with Familial Hypercholesterolaemia : The Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) Study Clinical drug investigation 2000;20 (2):67-79 [PubMed]
• Kastelein J. J. Screening for familial hypercholesterolaemia. Effective, safe treatments and dna testing make screening attractive BMJ (Clinical research ed.) 2000;321 (7275):1483-1484 [PubMed]
• Jukema J. W., Kastelein J. J. Tailored therapy to fit individual profiles. Genetics and coronary artery disease Annals of the New York Academy of Sciences 2000;902:17-24; discussion 24-6 [PubMed]
• Smilde T. J., van den Berkmortel F. W., Wollersheim H., van Langen H., Kastelein J. J., Stalenhoef A. F. The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia European journal of clinical investigation 2000;30 (6):473-480 [PubMed]
• Stalenhoef A. F., de Graaf J., Wittekoek M. E., Bredie S. J., Demacker P. N., Kastelein J. J. The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertriglyceridemia Atherosclerosis 2000;153 (1):129-138 [PubMed]
• Hoffer M. J., Snieder H., Bredie S. J., Demacker P. N., Kastelein J. J., Frants R. R., Stalenhoef A. F. The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia Atherosclerosis 2000;151 (2):443-450 [PubMed]

1999

• Gagné S. E., Larson M. G., Pimstone S. N., Schaefer E. J., Kastelein J. J., Wilson P. W., Ordovas J. M., Hayden M. R. A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study Clinical genetics 1999;55 (6):450-454 [PubMed]
• Minnema M. C., Wittekoek M. E., Schoonenboom N., Kastelein J. J., Hack C. E., ten Cate H. Activation of the contact system of coagulation does not contribute to the hemostatic imbalance in hypertriglyceridemia Arteriosclerosis, thrombosis, and vascular biology 1999;19 (10):2548-2553 [PubMed]
• Wittekoek M. E., Moll E., Pimstone S. N., Trip M. D., Lansberg P. J., Defesche J. C., van Doormaal J. J., Hayden M. R., Kastelein J. J. A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia Arteriosclerosis, thrombosis, and vascular biology 1999;19 (11):2708-2713 [PubMed]
• Hallman D. M., Groenemeijer B. E., Jukema J. W., Boerwinkle E., Kastelein J. J. Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci Annals of human genetics 1999;63 (Part 6):499-510 [PubMed]
• Wittekoek M. E., de Groot E., Prins M. H., Trip M. D., Büller H. R., Kastelein J. J. Differences in intima-media thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease Atherosclerosis 1999;146 (2):271-279 [PubMed]
• de Maat M. P., Jukema J. W., Ye S., Zwinderman A. H., Moghaddam P. H., Beekman M., Kastelein J. J., van Boven A. J., Bruschke A. V., Humphries S. E., Kluft C., Henney A. M. Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis American journal of cardiology 1999;83 (6):852-856 [PubMed]
• Verhaar M. C., Wever R. M., Kastelein J. J., van Loon D., Milstien S., Koomans H. A., Rabelink T. J. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial Circulation 1999;100 (4):335-338 [PubMed]
• Yu L., Heere-Ress E., Boucher B., Defesche J. C., Kastelein J., Lavoie M. A., Genest J. Familial hypercholesterolemia. Acceptor splice site (G-->C) mutation in intron 7 of the LDL-R gene: alternate RNA editing causes exon 8 skipping or a premature stop codon in exon 8. LDL-R(Honduras-1) [LDL-R1061(-1) G-->C] Atherosclerosis 1999;146 (1):125-131 [PubMed]
• Brooks-Wilson A., Marcil M., Clee S. M., Zhang L. H., Roomp K., van Dam M., Yu L., Brewer C., Collins J. A., Molhuizen H. O., Loubser O., Ouelette B. F., Fichter K., Ashbourne-Excoffon K. J., Sensen C. W., Scherer S., Mott S., Denis M., Martindale D., Frohlich J., Morgan K., Koop B., Pimstone S., Kastelein J. J., Genest J., Hayden M. R. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Nature genetics 1999;22 (4):336-345 [PubMed]
• Marcil M., Brooks-Wilson A., Clee S. M., Roomp K., Zhang L. H., Yu L., Collins J. A., van Dam M., Molhuizen H. O., Loubster O., Ouellette B. F., Sensen C. W., Fichter K., Mott S., Denis M., Boucher B., Pimstone S., Genest J., Kastelein J. J., Hayden M. R. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux Lancet 1999;354 (9187):1341-1346 [PubMed]
• Verhaar M. C., Honing M. L., van Dam T., Zwart M., Koomans H. A., Kastelein J. J., Rabelink T. J. Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids Cardiovascular research 1999;42 (3):752-760 [PubMed]
• Umans-Eckenhausen M. A., Defesche J. C., Scheerder R. L., Cliné F., Kastelein J. J. Opsporing van patiënten met familiaire hypercholesterolemie in Nederland Nederlands tijdschrift voor geneeskunde 1999;143 (22):1157-1161 [PubMed]
• Boer J. M., Kuivenhoven J. A., Feskens E. J., Schouten E. G., Havekes L. M., Seidell J. C., Kastelein J. J., Kromhout D. Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins Clinical genetics 1999;56 (2):158-163 [PubMed]
• Franco R. F., Trip M. D., ten Cate H., van den Ende A., Prins M. H., Kastelein J. J., Reitsma P. H. The 20210 G-->A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease British journal of haematology 1999;104 (1):50-54 [PubMed]
• Kastelein J. J. The future of best practice Atherosclerosis 1999;143 (Suppl. 1):S17-S21 [PubMed]
• Kastelein J. J., Ordovas J. M., Wittekoek M. E., Pimstone S. N., Wilson W. F., Gagné S. E., Larson M. G., Schaefer E. J., Boer J. M., Gerdes C., Hayden M. R. Two common mutations (D9N, N291S) in lipoprotein lipase: a cumulative analysis of their influence on plasma lipids and lipoproteins in men and women Clinical genetics 1999;56 (4):297-305 [PubMed]

1998

• de Maat M. P., Kastelein J. J., Jukema J. W., Zwinderman A. H., Jansen H., Groenemeier B., Bruschke A. V., Kluft C. -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group Arteriosclerosis, thrombosis, and vascular biology 1998;18 (2):265-271 [PubMed]
• Verhaar M. C., Wever R. M., Kastelein J. J., van Dam T., Koomans H. A., Rabelink T. J. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia Circulation 1998;97 (3):237-241 [PubMed]
• Wittekoek M. E., Pimstone S. N., Reymer P. W., Feuth L., Botma G. J., Defesche J. C., Prins M. [=Martin H.], Hayden M. R., Kastelein J. J. A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascular disease in patients with familial hypercholesterolemia Circulation 1998;97 (8):729-735 [PubMed]
• Rust S., Walter M., Funke H., von Eckardstein A., Cullen P., Kroes H. Y., Hordijk R., Geisel J., Kastelein J., Molhuizen H. O., Schreiner M., Mischke A., Hahmann H. W., Assmann G. Assignment of Tangier disease to chromosome 9q31 by a graphical linkage exclusion strategy Nature genetics 1998;20 (1):96-98 [PubMed]
• Hoffer M. J., Bredie S. J., Snieder H., Reymer P. W., Demacker P. N., Havekes L. M., Boomsma D. I., Stalenhoef A. F., Frants R. R., Kastelein J. J. Gender-related association between the -93T-->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia Atherosclerosis 1998;138 (1):91-99 [PubMed]
• Henderson H. E., Bijvoet S. M., Mannens M. A., Bruin T., Erkelens D. W., Hayden M. R., Kastelein J. J. Ile225Thr loop mutation in the lipoprotein lipase (LPL) gene is a de novo event American journal of medical genetics 1998;78 (4):313-316 [PubMed]
• Diekman T., Demacker P. N., Kastelein J. J., Stalenhoef A. F., Wiersinga W. M. Increased oxidizability of low-density lipoproteins in hypothyroidism Journal of clinical endocrinology and metabolism 1998;83 (5):1752-1755 [PubMed]
• von Eckardstein A., Huang Y., Kastelein J. J., Geisel J., Real J. T., Kuivenhoven J. A., Miccoli R., Noseda G., Assmann G. Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients Atherosclerosis 1998;138 (1):25-34 [PubMed]
• Defesche J. C., Kastelein J. J. Molecular epidemiology of familial hypercholesterolaemia Lancet 1998;352 (9141):1643-1644 [PubMed]
• von Eckardstein A., Chirazi A., Schuler-Lüttmann S., Walter M., Kastelein J. J., Geisel J., Real J. T., Miccoli R., Noseda G., Höbbel G., Assmann G. Plasma and fibroblasts of Tangier disease patients are disturbed in transferring phospholipids onto apolipoprotein A-I Journal of lipid research 1998;39 (5):987-998 [PubMed]
• Franco R. F., Zago M. A., Trip M. D., ten Cate H., van den Ende A., Prins M. H., Kastelein J. J., Reitsma P. H. Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease British journal of haematology 1998;102 (5):1172-1175 [PubMed]
• Kastelein J. J., Groenemeyer B. E., Hallman D. M., Henderson H., Reymer P. W., Gagné S. E., Jansen H., Seidell J. C., Kromhout D., Jukema J. W., Bruschke A. V., Boerwinkle E., Hayden M. R. The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group Clinical genetics 1998;53 (1):27-33 [PubMed]
• Verhoeff B. J., Trip M. D., Prins M. H., Kastelein J. J., Reitsma P. H. The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis Atherosclerosis 1998;141 (1):161-166 [PubMed]
• Prins J., van der Hoek Y. Y., Biesheuvel T. H., Leus F. R., van Rijn H. J., Kastelein J. J. The functional and clinical significance of the Met-->Thr substitution in Kringle IV type 10 of apolipoprotein(a) Thrombosis research 1998;90 (3):125-130 [PubMed]
• Kuivenhoven J. A., Jukema J. W., Zwinderman A. H., de Knijff P., McPherson R., Bruschke A. V., Lie K. I., Kastelein J. J. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group New England journal of medicine 1998;338 (2):86-93 [PubMed]

1997

• Lombardi P., Defesche J. C., Kamerling S. W., Kastelein J. J., Havekes L. M. A novel mutation M-21V in exon 1 of the low density lipoprotein receptor gene causing familial hypercholesterolemia Clinical genetics 1997;51 (6):430-431 [PubMed]
• Lombardi P., Defesche J. C., Kamerling S. W., Kastelein J. J., Havekes L. M. A novel V415A mutation in exon 9 of the low density lipoprotein receptor gene causing familial hypercholesterolemia Clinical genetics 1997;51 (4):286-287 [PubMed]
• Foubert L., Bruin T., de Gennes J. L., Ehrenborg E., Furioli J., Kastelein J., Benlian P., Hayden M. A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry Human mutation 1997;10 (3):179-185 [PubMed]
• Jansen H., Verhoeven A. J., Weeks L., Kastelein J. J., Halley D. J., van den Ouweland A., Jukema J. W., Seidell J. C., Birkenhäger J. C. Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients Arteriosclerosis, thrombosis, and vascular biology 1997;17 (11):2837-2842 [PubMed]
• Pimstone S. N., Defesche J. C., Clee S. M., Bakker H. D., Hayden M. R., Kastelein J. J. Differences in the phenotype between children with familial defective apolipoprotein B-100 and familial hypercholesterolemia Arteriosclerosis, thrombosis, and vascular biology 1997;17 (5):826-833 [PubMed]
• Kockx M., de Maat M. P., Knipscheer H. C., Kastelein J. J., Kluft C., Princen H. M., Kooistra T. Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients Thrombosis and haemostasis 1997;78 (4):1167-1172 [PubMed]
• Ehrenborg E., Clee S. M., Pimstone S. N., Reymer P. W., Benlian P., Hoogendijk C. F., Davis H. J., Bissada N., Miao L., Gagné S. E., Greenberg L. J., Henry R., Henderson H., Ordovas J. M., Schaefer E. J., Kastelein J. J., Kotze M. J., Hayden M. R. Ethnic variation and in vivo effects of the -93t-->g promoter variant in the lipoprotein lipase gene Arteriosclerosis, thrombosis, and vascular biology 1997;17 (11):2672-2678 [PubMed]
• Groenemeijer B. E., Hallman M. D., Reymer P. W., Gagné E., Kuivenhoven J. A., Bruin T., Jansen H., Lie K. I., Bruschke A. V., Boerwinkle E., Hayden M. R., Kastelein J. J. Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. REGRESS Study Group Circulation 1997;95 (12):2628-2635 [PubMed]
• Kuivenhoven J. A., de Knijff P., Boer J. M., Smalheer H. A., Botma G. J., Seidell J. C., Kastelein J. J., Pritchard P. H. Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels Arteriosclerosis, thrombosis, and vascular biology 1997;17 (3):560-568 [PubMed]
• Bakker H. D., Wiegman A., Defesche J. C., Kastelein J. J. Is opsporing en behandeling van familiaire hypercholesterolemie geïndiceerd bij kinderen? Nederlands tijdschrift voor geneeskunde 1997;141 (52):2548-2551 [PubMed]
• van der Hoek Y. Y., Wanders R. J., van den Ende A. E., Kraft H. G., Gabel B. R., Kastelein J. J., Koschinsky M. L. Lipoprotein[a] is not present in the plasma of patients with some peroxisomal disorders Journal of lipid research 1997;38 (8):1612-1619 [PubMed]
• Knipscheer H. C., Kindt I., van den Ende A., Nurmohamed M. T., Smalbraak H., Mulder Wubbo J., Kastelein J. J. Magnesium pyridoxal-5'-phosphate glutamate, "A vitamin B6 derivative", does not affect lipoprotein levels in patients with familial hypercholesterolaemia European journal of clinical pharmacology 1997;51 (6):499-503 [PubMed]
• de Maat M. P., Knipscheer H. C., Kastelein J. J., Kluft C. Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia Thrombosis and haemostasis 1997;77 (1):75-79 [PubMed]
• Lookene A., Groot N. B., Kastelein J. J., Olivecrona G., Bruin T. Mutation of tryptophan residues in lipoprotein lipase. Effects on stability, immunoreactivity, and catalytic properties Journal of biological chemistry 1997;272 (2):766-772 [PubMed]
• Hansen P. S., Defesche J. C., Kastelein J. J., Gerdes L. U., Fraza L., Gerdes C., Tato F., Jensen H. K., Jensen L. G., Klausen I. C., Faergeman O., Schuster H. Phenotypic variation in patients heterozygous for familial defective apolipoprotein B (FDB) in three European countries Arteriosclerosis, thrombosis, and vascular biology 1997;17 (4):741-747 [PubMed]
• Kuivenhoven J. A., Groenemeyer B. E., Boer J. M., Reymer P. W., Berghuis R., Bruin T., Jansen H., Seidell J. C., Kastelein J. J. Ser447stop mutation in lipoprotein lipase is associated with elevated HDL cholesterol levels in normolipidemic males Arteriosclerosis, thrombosis, and vascular biology 1997;17 (3):595-599 [PubMed]
• van der Hoek Y. Y., Lingenhel A., Kraft H. G., Defesche J. C., Kastelein J. J., Utermann G. Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB Journal of clinical investigation 1997;99 (9):2269-2273 [PubMed]
• Stroes E., Kastelein J., Cosentino F., Erkelens W., Wever R., Koomans H., Lüscher T., Rabelink T. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia Journal of clinical investigation 1997;99 (1):41-46 [PubMed]
• Prins J., Leus F. R., van der Hoek Y. Y., Kastelein J. J., Bouma B. N., van Rijn H. J. The identification and significance of a Thr-->Pro polymorphism in kringle IV type 8 of apolipoprotein(a) Thrombosis and haemostasis 1997;77 (5):949-954 [PubMed]
• Kuivenhoven J. A., Pritchard H., Hill J., Frohlich J., Assmann G., Kastelein J. The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes Journal of lipid research 1997;38 (2):191-205 [PubMed]
• Kluijtmans L. A., Kastelein J. J., Lindemans J., Boers G. H., Heil S. G., Bruschke A. V., Jukema J. W., van den Heuvel L. P., Trijbels F. J., Boerma G. J., Verheugt F. W., Willems F., Blom H. J. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease Circulation 1997;96 (8):2573-2577 [PubMed]

1996

• Bijvoet S., Gagné S. E., Moorjani S., Gagné C., Henderson H. E., Fruchart J. C., Dallongeville J., Alaupovic P., Prins M. [=Martin H.], Kastelein J. J., Hayden M. R. Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency Journal of lipid research 1996;37 (3):640-650 [PubMed]
• Kuivenhoven J. A., Weibusch H., Pritchard P. H., Funke H., Benne R., Assmann G., Kastelein J. J. An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder (fish-eye disease) Journal of clinical investigation 1996;98 (2):358-364 [PubMed]
• Knipscheer H. C., de Valois J. C., van den Ende B., ten Cate J. Wouter, Kastelein J. J. Ciprofibrate versus gemfibrozil in the treatment of primary hyperlipidaemia Atherosclerosis 1996;124 (Suppl):S75-S81 [PubMed]
• Bijvoet S. M., Wiebusch H., Ma Y., Reymer P. W., Bruin T., Bakker H. D., Funke H., Assmann G., Hayden M. R., Kastelein J. J. Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency Netherlands journal of medicine 1996;49 (5):189-195 [PubMed]
• Wiebusch H., Funke H., Bruin T., Bucher H., von Eckardstein A., Kastelein J. J., Assmann G. Compound heterozygosity for a known (D250N) and a novel (E410K) missense mutation in the C-terminal domain of lipoprotein lipase causes familial chylomicronemia Human mutation 1996;8 (4):381-383 [PubMed]
• Bredie S. J., Westerveld H. T., Knipscheer H. C., de Bruin T. W., Kastelein J. J., Stalenhoef A. F. Effects of gemfibrozil or simvastatin on apolipoprotein-B-containing lipoproteins, apolipoprotein-CIII and lipoprotein(a) in familial combined hyperlipidaemia Netherlands journal of medicine 1996;49 (2):59-67 [PubMed]
• Lombardi P., Kamerling S. W., Defesche J. C., Kastelein J. J., Havekes L. M. Identification of a double mutation in the low-density lipoprotein receptor gene causing familial hypercholesterolemia Clinical genetics 1996;50 (6):525-526 [PubMed]
• van den Ende A., van der Hoek Y. Y., Kastelein J. J., Koschinsky M. L., Labeur C., Rosseneu M. Lipoprotein [a] Advances in clinical chemistry 1996;32:73-134 [PubMed]
• Defesche J. C., van Diermen D. E., Hayden M. R., Kastelein J. P. Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia Gene geography 1996;10 (1):1-10 [PubMed]
• Knipscheer H. C., Boelen C. C., Kastelein J. J., van Diermen D. E., Groenemeijer B. E., van den Ende A., Büller H. R., Bakker H. D. Short-term efficacy and safety of pravastatin in 72 children with familial hypercholesterolemia Pediatric research 1996;39 (5):867-871 [PubMed]
• Jukema J. W., van Boven A. J., Groenemeijer B., Zwinderman A. H., Reiber J. H., Bruschke A. V., Henneman J. A., Molhoek G. P., Bruin T., Jansen H., Gagné E., Hayden M. R., Kastelein J. J. The Asp9 Asn mutation in the lipoprotein lipase gene is associated with increased progression of coronary atherosclerosis. REGRESS Study Group, Interuniversity Cardiology Institute, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study Circulation 1996;94 (8):1913-1918 [PubMed]
• Hoffer M. J., Bredie S. J., Boomsma D. I., Reymer P. W., Kastelein J. J., de Knijff P., Demacker P. N., Stalenhoef A. F., Havekes L. M., Frants R. R. The lipoprotein lipase (Asn291-->Ser) mutation is associated with elevated lipid levels in families with familial combined hyperlipidaemia Atherosclerosis 1996;119 (2):159-167 [PubMed]
• Kuivenhoven J. A., Stalenhoef A. F., Hill J. S., Demacker P. N., Errami A., Kastelein J. J., Pritchard P. H. Two novel molecular defects in the LCAT gene are associated with fish eye disease Arteriosclerosis, thrombosis, and vascular biology 1996;16 (2):294-303 [PubMed]

1995

• Reymer P. W., Gagné E., Groenemeyer B. E., Zhang H., Forsyth I., Jansen H., Seidell J. C., Kromhout D., Lie K. E., Kastelein J. A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis Nature genetics 1995;10 (1):28-34 [PubMed]
• Reymer P. W., Groenemeyer B. E., van de Burg R., Kastelein J. J. Apolipoprotein E genotyping on agarose gels Clinical chemistry 1995;41 (7):1046-1047 [PubMed]
• Kuivenhoven J. A., van Voorst tot Voorst E. J., Wiebusch H., Marcovina S. M., Funke H., Assmann G., Pritchard P. H., Kastelein J. J. A unique genetic and biochemical presentation of fish-eye disease Journal of clinical investigation 1995;96 (6):2783-2791 [PubMed]
• Bredie S. J., de Bruin T. W., Demacker P. N., Kastelein J. J., Stalenhoef A. F. Comparison of gemfibrozil versus simvastatin in familial combined hyperlipidemia and effects on apolipoprotein-B-containing lipoproteins, low-density lipoprotein subfraction profile, and low-density lipoprotein oxidizability American journal of cardiology 1995;75 (5):348-353 [PubMed]
• Lansberg P. J., Mitchel Y. B., Shapiro D., Kastelein J. J., Altman R., Jerums G., Bolzano K., Giannini S., Davignon J., DeWailly P. Long-term efficacy and tolerability of simvastatin in a large cohort of elderly hypercholesterolemic patients Atherosclerosis 1995;116 (2):153-162 [PubMed]
• Pimstone S. N., Gagné S. E., Gagné C., Lupien P. J., Gaudet D., Williams R. R., Kotze M., Reymer P. W., Defesche J. C., Kastelein J. J. Mutations in the gene for lipoprotein lipase. A cause for low HDL cholesterol levels in individuals heterozygous for familial hypercholesterolemia Arteriosclerosis, thrombosis, and vascular biology 1995;15 (10):1704-1712 [PubMed]
• Lombardi P., Sijbrands E. J., van de Giessen K., Smelt A. H., Kastelein J. J., Frants R. R., Havekes L. M. Mutations in the low density lipoprotein receptor gene of familial hypercholesterolemic patients detected by denaturing gradient gel electrophoresis and direct sequencing Journal of lipid research 1995;36 (4):860-867 [PubMed]
• Zhang H., Reymer P. W., Liu M. S., Forsythe I. J., Groenemeyer B. E., Frohlich J., Brunzell J. D., Kastelein J. J., Hayden M. R., Ma Y. Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291-->Ser mutation in the human LPL gene Arteriosclerosis, thrombosis, and vascular biology 1995;15 (10):1695-1703 [PubMed]
• Diekman T., Lansberg P. J., Kastelein J. J., Wiersinga W. M. Prevalence and correction of hypothyroidism in a large cohort of patients referred for dyslipidemia Archives of internal medicine 1995;155 (14):1490-1495 [PubMed]

1994

• Bruin T., Tuzgöl S., Mulder W. J., van den Ende A. E., Jansen H., Hayden M. R., Kastelein J. J. A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression Journal of lipid research 1994;35 (3):438-445 [PubMed]
• van der Hoek Y. Y., Kastelein J. J., Koschinsky M. L. Analysis of structure--function relationships in human apolipoprotein(a) Canadian journal of physiology and pharmacology 1994;72 (3):304-310 [PubMed]
• Tuzgöl S., Bijvoet S. M., Bruin T., Kastelein J. J., Hayden M. R. Apolipoprotein CII-Padova (Tyr37-->stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana Journal of medical genetics 1994;31 (8):622-626 [PubMed]
• van der Hoek Y. Y., Sangrar W., Côté G. P., Kastelein J. J., Koschinsky M. L. Binding of recombinant apolipoprotein(a) to extracellular matrix proteins Arteriosclerosis and thrombosis 1994;14 (11):1792-1798 [PubMed]
• Stalenhoef A. F., Defesche J. C., Kleinveld H. A., Demacker P. N., Kastelein J. J. Decreased resistance against in vitro oxidation of LDL from patients with familial defective apolipoprotein B-100 Arteriosclerosis and thrombosis 1994;14 (3):489-493 [PubMed]
• Knipscheer H. C., Nurmohamed M. T., van den Ende A., Plaat B., Pruijs H. J., Mulder W. J., Kastelein J. J. Gemfibrozil treatment of the high triglyceride-low high-density lipoprotein cholesterol trait in men with established atherosclerosis Journal of internal medicine 1994;236 (4):377-384 [PubMed]
• Bijvoet S. M., Bruin T., Tuzgöl S., Bakker H. D., Hayden M. R., Kastelein J. J. Homozygosity for a mutation in the lipoprotein lipase gene (Gly139-->Ser) causes chylomicronaemia in a boy of Spanish descent Human genetics 1994;93 (3):339-343 [PubMed]
• van den Broek A. J., Hollaar L., Schaefer H. I., van der Laarse A., Schuster H., Defesche J. C., Kastelein J. J., van 't Hooft F. M. Screening for familial defective apolipoprotein B-100 with improved U937 monocyte proliferation assay Clinical chemistry 1994;40 (3):395-399 [PubMed]
• Bruin T., Groot N. B., Jansen J., Kastelein J. J. The C-terminus of lipoprotein lipase is essential for biological function but contains no domain for glycosylphosphatidylinositol anchoring European Journal of Biochemistry / FEBS 1994;221 (3):1019-1025 [PubMed]
• Lansberg P. J., Knipscheer H. C., Kastelein J. J., Prins M. H., van der Ende A. E. The effect of Fiberform, a low-phytate wheat fibre, on plasma lipids and blood pressure of women with familial hypercholesterolaemia Journal of internal medicine 1994;236 (4):477-478 [PubMed]
• de Knijff P., van den Maagdenberg A. M., Boomsma D. I., Stalenhoef A. F., Smelt A. H., Kastelein J. J., Marais A. D., Frants R. R., Havekes L. M. Variable expression of familial dysbetalipoproteinemia in apolipoprotein E*2 (Lys146-->Gln) Allele carriers Journal of clinical investigation 1994;94 (3):1252-1262 [PubMed]

1993

• Defesche J. C., Lansberg P. J., Reymer P. W., Lamping R. J., Kastelein J. J. Analysis of the Afrikaner mutation in exon 9 of the low-density lipoprotein receptor gene in a large Dutch kindred suffering from familial hypercholesterolaemia Netherlands journal of medicine 1993;42 (1-2):53-60 [PubMed]
• Defesche J. C., Pricker K. L., Hayden M. R., van der Ende B. E., Kastelein J. J. Familial defective apolipoprotein B-100 is clinically indistinguishable from familial hypercholesterolemia Archives of internal medicine 1993;153 (20):2349-2356 [PubMed]
• Hayden M. R., Kastelein J. J., Funke H., Brunzell J. D., Ma Y. Phenotypic variation of mutations in the human lipoprotein-lipase gene Biochemical Society transactions 1993;21 (2):506-509 [PubMed]
• Bruin T., Tuzgöl S., van Diermen D. E., Hoogerbrugge-van der Linden N., Brunzell J. D., Hayden M. R., Kastelein J. J. Recurrent pancreatitis and chylomicronemia in an extended Dutch kindred is caused by a Gly154-->Ser substitution in lipoprotein lipase Journal of lipid research 1993;34 (12):2109-2119 [PubMed]
• Defesche J. C., van Diermen D. E., Lansberg P. J., Lamping R. J., Reymer P. W., Hayden M. R., Kastelein J. J. South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population Human genetics 1993;92 (6):567-570 [PubMed]
• Henderson H. E., Ma Y., Liu M. S., Clark-Lewis I., Maeder D. L., Kastelein J. J., Brunzell J. D., Hayden M. R. Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region Journal of lipid research 1993;34 (9):1593-1602 [PubMed]
• van der Hoek Y. Y., Wittekoek M. E., Beisiegel U., Kastelein J. J., Koschinsky M. L. The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms Human molecular genetics 1993;2 (4):361-366 [PubMed]
• Bijvoet S. M., Bruin T., Kastelein J. J. The familial hyperchylomicronaemia syndrome Netherlands journal of medicine 1993;42 (1-2):36-44 [PubMed]
• Stalenhoef A. F., Lansberg P. J., Kroon A. A., Kortmann B., de Haan A. F., Stuyt P. M., Kastelein J. J. Treatment of primary hypercholesterolaemia. Short-term efficacy and safety of increasing doses of simvastatin and pravastatin: a double-blind comparative study Journal of internal medicine 1993;234 (1):77-82 [PubMed]

1992

• Top B., Uitterlinden A. G., van der Zee A., Kastelein J. J., Leuven J. A., Havekes L. M., Frants R. R. Absence of mutations in the promoter region of the low density lipoprotein receptor gene in a large number of familial hypercholesterolaemia patients as revealed by denaturing gradient gel electrophoresis Human genetics 1992;89 (5):561-565 [PubMed]
• Ma Y., Wilson B. I., Bijvoet S., Henderson H. E., Cramb E., Roederer G., Ven Murthy M. R., Julien P., Bakker H. D., Kastelein J. J. A missense mutation (Asp250----Asn) in exon 6 of the human lipoprotein lipase gene causes chylomicronemia in patients of different ancestries Genomics 1992;13 (3):649-653 [PubMed]
• Bruin T., Kastelein J. J., van Diermen D. E., Ma Y., Henderson H. E., Stuyt P. M., Stalenhoef A. F., Sturk A., Brunzell J. D., Hayden M. R. A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity European Journal of Biochemistry / FEBS 1992;208 (2):267-272 [PubMed]
• Lansberg P. J., Kastelein J. J., Defesche J. C., ten Cate J. W. De behandeling van familiaire hypercholesterolemie Nederlands tijdschrift voor geneeskunde 1992;136 (15):734-738 [PubMed]
• Defesche J. C., van de Ree M. A., Kastelein J. J., van Diermen D. E., Janssens N. W., van Doormaal J. J., Hayden M. R. Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada Clinical genetics 1992;42 (6):273-280 [PubMed]
• Kastelein J. J., Pritchard P. H., Erkelens D. W., Kuivenhoven J. A., Albers J. J., Frohlich J. J. Familial high-density-lipoprotein deficiency causing corneal opacities (fish eye disease) in a family of Dutch descent Journal of internal medicine 1992;231 (4):413-419 [PubMed]
• Dekker E., Büller H. R., Kastelein J. J. Postmenopauzale oestrogeensubstitutie en het risico van atherosclerotische hart- en vaatziekten Nederlands tijdschrift voor geneeskunde 1992;136 (25):1197-1200 [PubMed]
• Ma Y. H., Bruin T., Tuzgol S., Wilson B. I., Roederer G., Liu M. S., Davignon J., Kastelein J. J., Brunzell J. D., Hayden M. R. Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis Journal of biological chemistry 1992;267 (3):1918-1923 [PubMed]

1991

• Bruin T., Reymer P. W., Groenemeyer B. E., Talmud P. J., Kastelein J. J. HindIII-polymorphism in the LPL-gene detected by PCR Nucleic acids research 1991;19 (22):6346 [PubMed]
• Bakker H. D., Bruin T., Schaap M. C., Lansberg P. J., Kastelein J. J. The prediction of the therapeutic response to cholesterol lowering drugs in an 11-year-old boy with homozygous familial hypercholesterolaemia Journal of inherited metabolic disease 1991;14 (3):389-392 [PubMed]