S. Mastenbroek PhD publications

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Publications PhD S. Mastenbroek

Positions
Research Associate, MD-PhD
Main activities
Patient care, Research
Specialisation
Clinical Embryologist
Focus of research

Dr. Sebastiaan Mastenbroek is an Assistant Professor and one of the Clinical Embryologists of the Center for Reproductive Medicine of the Amsterdam UMC.

An important focus of his research has been Preimplantation Genetic Screening (PGS). Publication of his RCT on PGS in the New England Journal of Medicine started a fiercely debated controversy on the use of PGS as it showed that the technique actually lowered pregnancy rates after IVF instead of increasing them. He actively participated in this debate and published research that provided technical as well as biological reasons for the inefficacy of PGS.

In recent years his research focusses on early human development, improvement of human preimplantation embryo quality, assisted reproductive techniques, and evidence based laboratory practice. He supervised multiple randomized clinical trials. One of these trials demonstrated one embryo culture medium to be superior to another in terms of live birth rate after IVF, but it also demonstrated, for the first time by means of a large RCT, that there was a difference in birth weight of the children born after using these two media. He aims to find biological plausibility for the clinical outcomes of the trials. Like the transcriptome analysis of single embryos that demonstrated increased apoptosis pathways in the medium that resulted in less pregnancies. Furthermore, he aims to increase the basic understanding of human embryo development and implantation. His group demonstrated that high-quality human preimplantation embryos actively stimulate decidualized human endometrial stromal cell migration to increase their chances of successful implantation. They then identified the factor responsible for this newly discovered communication between embryo and endometrium.

He is a board member of the SAF foundation (stichting-saf.nl), chair of the LSFD laboratory working group, board member of the special interest group ART of the Dutch Society of Obstetrics and Gynaecology, board member of the Amsterdam Reproduction and Development Research Institute, associate editor of Human Reproduction Open, editor of the Cochrane Gynaecology and Fertility Group, and chair of the Science Committee of the Dutch Society for Clinical Embryology.

 

ORCID: orcid.org/0000-0002-7550-2924

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Cornelisse Simone, Ramos Liliana, Arends Brigitte, Brink-van der Vlugt Janneke J., de Bruin Jan Peter, Curfs Max H. J. N., Derhaag Josien, van Dongen Angelique, van Echten-Arends Jannie, Groenewoud Eva R., Maas Jacques W. M., Pieterse Quirine, van Santbrink Evert J. P., Slappendel Els, Traas Maaike A. F., Visser Jantien, Vergouw Carlijn G., Verhoeve Harold R., van der Westerlaken Lucette A. J., Wurth Yvonne, van der Zanden Moniek, Braat Didi D. M., van Wely Madelon, Mastenbroek Sebastiaan, Fleischer Kathrin Comparing the cumulative live birth rate of cleavage-stage versus blastocyst-stage embryo transfers between IVF cycles: A study protocol for a multicentre randomised controlled superiority trial (the ToF trial) BMJ open 2021;11 (1) [PubMed]

2020

  • Tarahomi Majid A comparison of the in vivo and in vitro environment of the human preimplantation embryo 2020. 139p. ISBN 9789648237467. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Repping Sjoerd; Co-supervisor: Mastenbroek Sebastiaan)
  • Mulder Callista L., Wattimury Tess M., Jongejan Aldo, de Winter-Korver Cindy M., van Daalen Saskia K. M., Struijk Robert B., Borgman Susanne C. M., Wurth Yvonne, Consten Dimitri, van Echten-Arends Jannie, Mastenbroek Sebastiaan, Dumoulin John C. M., Repping Sjoerd, van Pelt Ans M. M., van Montfoort Aafke P. A. Comparison of DNA methylation patterns of parentally imprinted genes in placenta derived from IVF conceptions in two different culture media Human reproduction (Oxford, England) 2020;35 (3):516-528 [PubMed]
  • Smits Myrthe A. J., van Maarle Merel, Hamer Geert, Mastenbroek Sebastiaan, Goddijn Mariëtte, van Wely Madelon Cytogenetic testing of pregnancy loss tissue: a meta-analysis Reproductive biomedicine online 2020;40 (6):867-879 [PubMed]
  • Berkhout Robbert P., Keijser Remco, Repping Sjoerd, Lambalk Cornelis B., Afink Gijs B., Mastenbroek Sebastiaan, Hamer Geert High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a Human reproduction (Oxford, England) 2020;35 (8):1797-1807 [PubMed]
  • Cornelisse Simone, Zagers Miriam, Kostova Elena, Fleischer Kathrin, van Wely Madelon, Mastenbroek Sebastiaan Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation Cochrane database of systematic reviews (Online) 2020;2020 (9) [PubMed]
  • Berkhout Robbert P, Lambalk Cornelis B, Repping Sjoerd, Hamer Geert, Mastenbroek Sebastiaan Premature expression of the decidualization marker prolactin is associated with repeated implantation failure Gynecological endocrinology 2020;36 (4):360-364 [PubMed]

2019

  • Wilkinson J., Brison D. R., Duffy J. M. N., Farquhar C. M., Lensen S., Mastenbroek S., van Wely M., Vail A. Don't abandon RCTs in IVF. We don't even understand them Human reproduction (Oxford, England) 2019;34 (11):2093-2098
  • Farquhar Cynthia M., Bhattacharya Siladitya, Repping Sjoerd, Mastenbroek Sebastiaan, Kamath Mohan S., Marjoribanks Jane, Boivin Jacky Female subfertility Nature reviews. Disease primers 2019;5 (1) [PubMed]
  • Zaat Tjitske, Mol Femke, van Wely Madelon, Wilkinson Jack, Mastenbroek Sebastiaan Fresh versus frozen blastocyst transfer Lancet 2019;394 (10205):1227 [PubMed]
  • Berkhout Robbert P. Insights into embryo implantation in humans 2019. 155p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Repping S. , Lambalk C. B.; Co-supervisors: Mastenbroek S. , Hamer G.)
  • Tarahomi M, Vaz F M, Straalen J P van, Schrauwen F A P, Wely M van, Hamer G, Repping S, Mastenbroek S The composition of human preimplantation embryo culture media and their stability during storage and culture Human reproduction (Oxford, England) 2019;34 (8):1450-1461 [PubMed]

2018

  • Smits M. A. J., Wong K. M., Mantikou E., Korver C. M., Jongejan A., Breit T. M., Goddijn M., Mastenbroek S., Repping S. Age-related gene expression profiles of immature human oocytes Molecular human reproduction 2018;24 (10):469-477 [PubMed]
  • Cornelisse Simone, Fleischer Kathrin, Repping Sjoerd, Mastenbroek Sebastiaan An informed decision between cleavage-stage and blastocyststage transfer in IVF requires data on the transfers of frozen-thawed embryos Human reproduction (Oxford, England) 2018;33 (7):1370-1371 [PubMed]
  • Kuiper Derk, Bennema Anne, La Bastide-van Gemert Sacha, Seggers Jorien, Schendelaar Pamela, Mastenbroek Sebastiaan, Hoek Annemieke, Heineman Maas Jan, Roseboom Tessa J., Kok Joke H., Hadders-Algra Mijna Developmental outcome of 9-year-old children born after PGS: follow-up of a randomized trial Human reproduction (Oxford, England) 2018;33 (1):147-155 [PubMed]
  • Berkhout R. P., Lambalk C. B., Huirne J., Mijatovic V., Repping S., Hamer G., Mastenbroek S. High-quality human preimplantation embryos actively influence endometrial stromal cell migration Journal of assisted reproduction and genetics 2018;35 (4):659–667 [PubMed]
  • Tarahomi Majid, de Melker Annemieke A., van Wely Madelon, Hamer Geert, Repping Sjoerd, Mastenbroek Sebastiaan pH stability of human preimplantation embryo culture media: effects of culture and batches Reproductive biomedicine online 2018;37 (4):409-414 [PubMed]
  • Zheng Yi, Lei Qijing, Jongejan Aldo, Mulder Callista L., van Daalen Saskia K. M., Mastenbroek Sebastiaan, Hwang Grace, Jordan Philip W., Repping Sjoerd, Hamer Geert The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells DNA repair 2018;70:55-66 [PubMed]

2017

  • Braakhekke M., Mol F., Mastenbroek S., Mol B. Willem J., van der Veen F. Equipoise and the RCT Human reproduction (Oxford, England) 2017;32 (2):257-260 [PubMed]
  • Wong Kai Mee, van Wely Madelon, Mol Femke, Repping Sjoerd, Mastenbroek Sebastiaan Fresh versus frozen embryo transfers in assisted reproduction Cochrane database of systematic reviews (Online) 2017;2017 (3):CD011184 [PubMed]
  • Kleijkers Sander H. M., Mantikou Eleni, Slappendel Els, Consten Dimitri, van Echten-Arends Jannie, Wetzels Alex M., van Wely Madelon, Smits Luc J. M., van Montfoort Aafke P. A., Repping Sjoerd, Dumoulin John C. M., Mastenbroek Sebastiaan Reply II: Embryo culture media effects Human reproduction (Oxford, England) 2017;32 (3):717-718 [PubMed]
  • Berkhout R P, Vergouw C G, van Wely M, de Melker A A, Schats R, Repping S, Hamer G, Mastenbroek S, Lambalk C B The addition of a low-quality embryo as part of a fresh day 3 double embryo transfer does not improve ongoing pregnancy rates Human reproduction open 2017;2017 (3):hox020 [PubMed]
  • Zheng Yi, Jongejan Aldo, Mulder Callista L., Mastenbroek Sebastiaan, Repping Sjoerd, Wang Yinghua, Li Jinsong, Hamer Geert Trivial role for NSMCE2 during in vitro proliferation and differentiation of male germline stem cells Reproduction (Cambridge, England) 2017;154 (3):181-195 [PubMed]

2016

  • Mantikou Eleni, Bruning Oskar, Mastenbroek Sebastiaan, Repping Sjoerd, Breit Timo Markus, de Jong Mark Evaluation of ribonucleic acid amplification protocols for human oocyte transcriptome analysis Fertility and sterility 2016;105 (2):511-9.e4 [PubMed]
  • Franz Cordula, Böing Anita N., Montag Markus, Strowitzki Thomas, Markert Udo R., Mastenbroek Sebastiaan, Nieuwland Rienk, Toth Bettina Extracellular vesicles in human follicular fluid do not promote coagulation Reproductive biomedicine online 2016;33 (5):652-655 [PubMed]
  • Mantikou E., Jonker M. J., Wong K. M., van Montfoort A. P. A., de Jong M., Breit T. M., Repping S., Mastenbroek S. Factors affecting the gene expression of in vitro cultured human preimplantation embryos Human reproduction (Oxford, England) 2016;31 (2):298-311 [PubMed]
  • Kleijkers Sander H. M., Mantikou Eleni, Slappendel Els, Consten Dimitri, van Echten-Arends Jannie, Wetzels Alex M., van Wely Madelon, Smits Luc J. M., van Montfoort Aafke P. A., Repping Sjoerd, Dumoulin John C. M., Mastenbroek Sebastiaan Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT Human reproduction (Oxford, England) 2016;31 (10):2219-2230 [PubMed]
  • Sermon Karen, Capalbo Antonio, Cohen Jacques, Coonen Edith, de Rycke Martine, de Vos Anick, Delhanty Joy, Fiorentino Francesco, Gleicher Norbert, Griesinger Georg, Grifo Jamie, Handyside Alan, Harper Joyce, Kokkali Georgia, Mastenbroek Sebastiaan, Meldrum David, Meseguer Marcos, Montag Markus, Munné Santiago, Rienzi Laura, Rubio Carmen, Scott Katherine, Scott Richard, Simon Carlos, Swain Jason, Treff Nathan, Ubaldi Filippo, Vassena Rita, Vermeesch Joris Robert, Verpoest Willem, Wells Dagan, Geraedts Joep The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists Molecular human reproduction 2016;22 (8):845-857 [PubMed]

2015

  • Youssef Mohamed M. A., Mantikou Eleni, van Wely Madelon, van der Veen Fulco, Al-Inany Hesham G., Repping Sjoerd, Mastenbroek Sebastiaan Culture media for human pre-implantation embryos in assisted reproductive technology cycles Cochrane database of systematic reviews (Online) 2015;2015 (11):CD007876 [PubMed]
  • Kleijkers Sander H. M., Eijssen Lars M. T., Coonen Edith, Derhaag Josien G., Mantikou Eleni, Jonker Martijs J., Mastenbroek Sebastiaan, Repping Sjoerd, Evers Johannes L. H., Dumoulin John C. M., van Montfoort Aafke P. A. Differences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media Human reproduction (Oxford, England) 2015;30 (10):2303-2311 [PubMed]
  • Vissenberg R., Manders V. D., Mastenbroek S., Fliers E., Afink G. B., Ris-Stalpers C., Goddijn M., Bisschop P. H. Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction Human reproduction update 2015;21 (3):378-387 [PubMed]
  • Armstrong Sarah, Vail Andy, Mastenbroek Sebastiaan, Jordan Vanessa, Farquhar Cindy Reply: time-lapse in the IVF lab: how should we assess potential benefit? Human reproduction (Oxford, England) 2015;30 (5):1277 [PubMed]
  • Armstrong S., Vail A., Mastenbroek S., Jordan V., Farquhar C. Time-lapse in the IVF-lab: how should we assess potential benefit? Human reproduction (Oxford, England) 2015;30 (1):3-8 [PubMed]

2014

  • Wong Kai Mee, Mastenbroek Sebastiaan, Repping Sjoerd Cryopreservation of human embryos and its contribution to in vitro fertilization success rates Fertility and sterility 2014;102 (1):19-26 [PubMed]
  • Wong Kai Mee, Repping Sjoerd, Mastenbroek Sebastiaan Limitations of embryo selection methods Seminars in reproductive medicine 2014;32 (2):127-133 [PubMed]
  • Mastenbroek Sebastiaan, Repping Sjoerd Preimplantation genetic screening: back to the future Human reproduction (Oxford, England) 2014;29 (9):1846-1850 [PubMed]

2013

  • Mantikou E., Youssef M. A. F. M., van Wely M., van der Veen F., Al-Inany H. G., Repping S., Mastenbroek S. Embryo culture media and IVF/ICSI success rates: a systematic review Human reproduction update 2013;19 (3):210-220 [PubMed]
  • Mantikou Eleni Improving embryo quality in assisted reproduction 2013. 181p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Repping S.; Co-supervisor: Mastenbroek S.)
  • Mantikou E., Bontekoe S., van Wely M., Seshadri S., Repping S., Mastenbroek S. Low oxygen concentrations for embryo culture in assisted reproductive technologies Human reproduction update 2013;19 (3):209 [PubMed]
  • Beukers Fenny, van der Heide Maaike, Middelburg Karin J., Cobben Jan Maarten, Mastenbroek Sebastiaan, Breur Rinske, van der Lee Johanna H., Hadders-Algra Mijna, Bos Arend F., Kok Joke H., Houtzager Bregje A., Repping Sjoerd, Twisk Moniek, van der Veen Fulco, Haadsma Maaike, Heineman Maas Jan, van Hoften Jacorina, Jongbloed-Pereboom Marjolein, Keating Paul, Seggers Jorien Morphologic abnormalities in 2-year-old children born after in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening: follow-up of a randomized controlled trial Fertility and sterility 2013;99 (2):408-413 [PubMed]
  • Mastenbroek Sebastiaan One swallow does not make a summer Fertility and sterility 2013;99 (5):1205-1206 [PubMed]
  • Mastenbroek S., Twisk M., van der Veen F., Repping S. Preimplantation genetic screening: a systematic review and meta-analysis of RCTs : Erratum Human reproduction update 2013;19 (2):206
  • Mantikou Eleni, van Echten-Arends Jannie, Sikkema-Raddatz Birgit, van der Veen Fulco, Repping Sjoerd, Mastenbroek Sebastiaan Temporal and developmental-stage variation in the occurrence of mitotic errors in tripronuclear human preimplantation embryos Biology of reproduction 2013;89 (2):42 [PubMed]

2012

  • Bontekoe Stephan, Mantikou Eleni, van Wely Madelon, Seshadri Srividya, Repping Sjoerd, Mastenbroek Sebastiaan Low oxygen concentrations for embryo culture in assisted reproductive technologies Cochrane database of systematic reviews (Online) 2012;2012 (7):CD008950 [PubMed]
  • Mantikou Eleni, Wong Kai Mee, Repping Sjoerd, Mastenbroek Sebastiaan Molecular origin of mitotic aneuploidies in preimplantation embryos BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (12):1921-1930 [PubMed]
  • Beukers F., Houtzager B. A., Paap M. C. S., Middelburg K. J., Hadders-Algra M., Bos A. F., Kok J. H., Cobben Jan Maarten, van der Heide Maaike, Koomen Alice, Repping Sjoerd, Silberbusch Lobke, Twisk Moniek, Mastenbroek Sebastiaan, van der Veen Fulco, Bos Arend F., Haadsma Maaike, Hadders-Algra Mijna, Heineman Maas Jan, van Hoften Jacorina, Jongbloed-Pereboom Marjolein, Keating Paul, Seggers Jorien Parental psychological distress and anxiety after a successful IVF/ICSI procedure with and without preimplantation genetic screening: Follow-up of a randomised controlled trial Early human development 2012;88 (9):725-730 [PubMed]
  • Musters A. M., van Wely M., Mastenbroek S., Kaaijk E. M., Repping S., van der Veen F., Mochtar M. H. The effect of recombinant LH on embryo quality: a randomized controlled trial in women with poor ovarian reserve Human reproduction (Oxford, England) 2012;27 (1):244-250 [PubMed]

2011

  • van Echten-Arends Jannie, Mastenbroek Sebastiaan, Sikkema-Raddatz Birgit, Korevaar Johanna C., Heineman Maas Jan, van der Veen Fulco, Repping Sjoerd Chromosomal mosaicism in human preimplantation embryos: a systematic review Human reproduction update 2011;17 (5):620-627 [PubMed]
  • Mastenbroek Sebastiaan, van der Veen Fulco, Aflatoonian Abbas, Shapiro Bruce, Bossuyt Patrick, Repping Sjoerd Embryo selection in IVF Human reproduction (Oxford, England) 2011;26 (5):964-966 [PubMed]
  • Musters Anna M., Repping Sjoerd, Korevaar Johanna C., Mastenbroek Sebastiaan, Limpens Jacqueline, van der Veen Fulco, Goddijn Mariëtte Pregnancy outcome after preimplantation genetic screening or natural conception in couples with unexplained recurrent miscarriage: a systematic review of the best available evidence Fertility and sterility 2011;95 (6):2153-2157 [PubMed]
  • Mastenbroek Sebastiaan Preimplantation genetic screening. A reappraisal 2011. 127p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van der Veen F., Repping S.; Co-supervisors: Heineman M. J., Bossuyt P. M.)
  • Mastenbroek S., Twisk M., van der Veen F., Repping S. Preimplantation genetic screening: a systematic review and meta-analysis of RCTs Human reproduction update 2011;17 (4):454-466 [PubMed]

2008

  • Musters Anna M., Goddijn Mariette, Korevaar Johanna C., van der Veen Fulco, Mastenbroek Sebastiaan, Repping Sjoerd Benefits of PGD in patients with recurrent miscarriages? Fertility and sterility 2008;90 (1):240-241 [PubMed]
  • Twisk Moniek, Mastenbroek Sebastiaan, Hoek Annemieke, Heineman Maas-Jan, van der Veen Fulco, Bossuyt Patrick M., Repping Sjoerd, Korevaar Johanna C. No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy Human reproduction (Oxford, England) 2008;23 (12):2813-2817 [PubMed]
  • Mastenbroek S., Twisk M., van der Veen F., Repping S. Preimplantation genetic screening Reproductive biomedicine online 2008;17 (2):293; author reply 294-293; author reply 295 [PubMed]
  • Mastenbroek S., Scriven P., Twisk M., Viville S., van der Veen F., Repping S. What next for preimplantation genetic screening? More randomized controlled trials needed? Human reproduction (Oxford, England) 2008;23 (12):2626-2628 [PubMed]

2007

  • Mastenbroek Sebastiaan, Twisk Moniek, van Echten-Arends Jannie, Sikkema-Raddatz Birgit, Korevaar Johanna C., Verhoeve Harold R., Vogel Niels E. A., Arts Eus G. J. M., de Vries Jan W. A., Bossuyt Patrick M., Buys Charles H. C. M., Heineman Maas Jan, Repping Sjoerd, van der Veen Fulco In vitro fertilization with preimplantation genetic screening New England journal of medicine 2007;357 (1):9-17 [PubMed]
  • Mastenbroek Sebastiaan, van der Veen Fulco, Repping Sjoerd In vitro fertilization with preimplantation genetic screening - Reply New England journal of medicine 2007;357 (17):1770-1771
  • Twisk Moniek, Haadsma Maaike L., van der Veen Fulco, Repping Sjoerd, Mastenbroek Sebastiaan, Heineman Maas-Jan, Bossuyt Patrick M. M., Korevaar Johanna C. Preimplantation genetic screening as an alternative to prenatal testing for Down syndrome: preferences of women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment Fertility and sterility 2007;88 (4):804-810 [PubMed]

2006

  • Mastenbroek Sebastiaan, Goddijn Mariette, van der Veen Fulco, Repping Sjoerd, Bossuyt Patrick M. M., Korevaar Johanna C., Twisk Moniek, Heineman Maas Jan PGD--a model to evaluate efficacy? Fertility and sterility 2006;85 (2):534-5; author reply 535-6 [PubMed]
  • Twisk M., Mastenbroek S., van Wely M., Heineman M. J., van der Veen F., Repping S. Preimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in vitro fertilisation or intracytoplasmic sperm injection Cochrane database of systematic reviews (Online) 2006;2006 (1):CD005291 [PubMed]

2005

  • Mastenbroek Sebastiaan, M M Bossuyt Patrick, Heineman Maas Jan, Repping Sjoerd, van der Veen Fulco Comment 1 on Staessen et al. (2004). Design and analysis of a randomized controlled trial studying preimplantation genetic screening Human reproduction (Oxford, England) 2005;20 (8):2362-2363 [PubMed]
  • Twisk Moniek, Mastenbroek Sebastiaan, Bossuyt Patrick M. M., Korevaar Johanna C., Heineman Maas-Jan, Repping Sjoerd, van der Veen Fulco The effectiveness of preimplantation genetic screening Reproductive biomedicine online 2005;11 (4):519-520 [PubMed]

2004

  • Mastenbroek S., Engel C., van Echten-Arends J., Sikkema-Raddatz B., van Wassenaer A. G., de Vries J. W. A., Heineman M. J., Repping S., van der Veen F. Preimplantatiegenetische screening op numerieke chromosoomafwijkingen bij embryo's van vrouwen van 35 jaar en ouder; de eerste resultaten in Nederland Nederlands tijdschrift voor geneeskunde 2004;148 (50):2486-2490 [PubMed]

2000

  • Feenstra M. G., Botterblom M. H., Mastenbroek S. Dopamine and noradrenaline efflux in the prefrontal cortex in the light and dark period: Effects of novelty and handling and comparison to the nucleus accumbens Neuroscience 2000;100 (4):741-748 [PubMed]
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