S.M. Hermans MD MSc PhD publications

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Publications MD MSc PhD S.M. Hermans

Position
Assistant Professor
Main activities
Patient care, Research
Specialisation
Internal Medicine, Infectious Diseases; Epidemiology (MSc)
Focus of research

As an infectious diseases physician and epidemiologist with more than 10 years of experience living and working in various sub-Saharan African countries, I have a varied, complementary and unique skill-set. My research interests include HIV and tuberculosis (co-)infection, in particular recurrent tuberculosis, and optimal strategies of HIV and TB health care delivery in sub-Saharan Africa.

Within the realm of HIV and TB, I specialize in the analysis of large-scale routinely collected data using up-to-date techniques, and prospective studies of the impact of health care interventions. My expertise enables me to collaborate effectively with basic scientists as well as public health experts, mathematical modellers, clinicians and policy makers.

My work analyzing a decade of routinely collected TB data in Cape Town, South Africa, and Kampala, Uganda has led to my current research focus on recurrent TB. My aim is to determine the mechanisms underlying the increased risk of recurrent TB to identify better approaches for TB control, both in the area of TB vaccines and adapted screening or treatment approaches.

Other current work includes a prospective study of the most effective TB screening strategy in the context of Universal HIV Test and Treat (UTT) in rural Tanzania, operational research on the effectiveness of UTT in that setting, and an evaluation of a new stool-based PCR for diagnosis of TB in children and people living with HIV in Uganda, Mozambique and Eswatini (Stool4TB study).

Recently, I was awarded three grants for projects which are about to start: a prospective cohort study to implement and evaluate novel drug regimens for multi- and extensive drug resistant TB in South Africa, Nigeria, Ethiopia and Tanzania (T2RiAD study), and two studies into the transmission and impact of the COVID-19 pandemic in South Africa.

I am passionate about capacity development and am involved in teaching and mentorship of students at various levels including bachelor and master theses (BSc Medicine and MSc Health Sciences). I am the co-promotor of four PhD students undertaking research into HIV and TB epidemiology in Tanzania (2) and South Africa (2).

Amsterdam UMC Research Institutes
AMC departments
All publications

2020

  • Kerkhoff Andrew D., Longley Nicky, Kelly Nicola, Cross Anna, Vogt Monica, Wood Robin, Hermans Sabine, Lawn Stephen D., Harrison Thomas S. Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa BMC infectious diseases 2020;20 (1):555 [PubMed]
  • Okere Nwanneka Ebelechukwu, Urlings Lisa, Naniche Denise, de Wit Tobias F. Rinke, Gomez Gabriela B., Hermans Sabine Evaluating the sustainability of differentiated service delivery interventions for stable ART clients in sub-Saharan Africa: A systematic review protocol BMJ open 2020;10 (1) [PubMed]
  • Hermans Sabine M, Zinyakatira Nesbert, Caldwell Judy, Cobelens Frank G J, Boulle Andrew, Wood Robin High rates of recurrent TB disease: a population-level cohort study Clinical infectious diseases 2020 [PubMed]
  • Andrews J. R., Cobelens F., Horsburgh C. R., Hatherill M., Basu S., Hermans S., Wood R. Seasonal drivers of tuberculosis: evidence from over 100 years of notifications in Cape Town international journal of tuberculosis and lung disease 2020;24 (5):477-484 [PubMed]

2019

  • Peters Julian S., Andrews Jason R., Hatherill Mark, Hermans Sabine, Martinez Leonardo, Schurr Erwin, van der Heijden Yuri, Wood Robin, Rustomjee Roxana, Kana Bavesh D. Advances in the understanding of Mycobacterium tuberculosis transmission in HIV-endemic settings Lancet infectious diseases 2019;19 (3):e65-e76
  • Zawedde-Muyanja Stella, Manabe Yukari C., Musaazi Joseph, Mugabe Frank R., Ross Jennifer M., Hermans Sabine Anti-retroviral therapy scale-up and its impact on sex-stratified tuberculosis notification trends in Uganda Journal of the International AIDS Society 2019;22 (9):e25394 [PubMed]
  • Martinez Leonardo, Verma Renu, Croda Julio, Horsburgh C. Robert, Walter Katharine S., Degner Nicholas, Middelkoop Keren, Koch Anastasia, Hermans Sabine, Warner Digby F., Wood Robin, Cobelens Frank, Andrews Jason R. Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications European respiratory journal 2019;53 (6) [PubMed]
  • Mulongeni Pancho, Hermans Sabine, Caldwell Judy, Bekker Linda-Gail, Wood Robin, Kaplan Richard HIV prevalence and determinants of loss-to-follow-up in adolescents and young adults with tuberculosis in Cape Town PLoS ONE 2019;14 (2) [PubMed]
  • Cevaal Paula M., Bekker Linda-Gail, Hermans Sabine TB-IRIS pathogenesis and new strategies for intervention: Insights from related inflammatory disorders Tuberculosis (Edinburgh, Scotland) 2019;118 [PubMed]
  • Hermans Sabine, Cornell Morna, Middelkoop Keren, Wood Robin The differential impact of HIV and antiretroviral therapy on gender-specific tuberculosis rates Tropical medicine & international health 2019;24 (4):454-462 [PubMed]

2018

  • Tedijanto Christine, Hermans Sabine, Cobelens Frank, Wood Robin, Andrews Jason R. Drivers of Seasonal Variation in Tuberculosis Incidence: Insights from a Systematic Review and Mathematical Model Epidemiology (Cambridge, Mass.) 2018;29 (6):857-866 [PubMed]
  • Burnett Sarah M., Zawedde-Muyanja Stella, Hermans Sabine M., Weaver Marcia R., Colebunders Robert, Manabe Yukari C. Effect of TB/HIV Integration on TB and HIV Indicators in Rural Ugandan Health Facilities JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 2018;79 (5):605-611 [PubMed]
  • Kaplan Richard, Hermans Sabine, Caldwell Judy, Jennings Karen, Bekker Linda-Gail, Wood Robin HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town BMC infectious diseases 2018;18 (1) [PubMed]
  • Verma Sheetal, du Peicheng, Nakanjako Damalie, Hermans Sabine, Briggs Jessica, Nakiyingi Lydia, Ellner Jerrold J., Manabe Yukari C., Salgame Padmini "Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets" BMC infectious diseases 2018;18 (1) [PubMed]

2017

  • Janssen S., Osbak K., Holman R., Hermans S., Moekotte A., Knap M., Rossatanga E., Massinga-Loembe M., Alabi A., Adegnika A., Meenken C., van Vugt M., Kremsner P. G., Meintjes G., van der Poll T., Grobusch M. P. Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study Infection 2017;45 (5):669-676 [PubMed]
  • Hermans Sabine M., Elbireer Sawsan, Tibakabikoba Harriet, Hoefman Bas J., Manabe Yukari C. Text messaging to decrease tuberculosis treatment attrition in TB-HIV coinfection in Uganda Patient preference and adherence 2017;11:1479-1487 [PubMed]
  • Hermans Sabine, Caldwell Judy, Kaplan Richard, Cobelens Frank, Wood Robin The impact of the roll-out of rapid molecular diagnostic testing for tuberculosis on empirical treatment in Cape Town, South Africa Bulletin of the World Health Organization 2017;95 (8):554-563 [PubMed]
  • Hermans Sabine M., Babirye Juliet A., Mbabazi Olive, Kakooza Francis, Colebunders Robert, Castelnuovo Barbara, Sekaggya-Wiltshire Christine, Parkes-Ratanshi Rosalind, Manabe Yukari C. Treatment decisions and mortality in HIV-positive presumptive smear-negative TB in the Xpert™ MTB/RIF era: a cohort study BMC infectious diseases 2017;17 (1):433 [PubMed]

2016

  • Kaplan R., Caldwell J., Hermans S., Adriaanse S., Mtwisha L., Bekker L.-G., Jennings K., Wood R. An integrated community TB-HIV adherence model provides an alternative to DOT for tuberculosis patients in Cape Town international journal of tuberculosis and lung disease 2016;20 (9):1185-1191 [PubMed]
  • Ford Nathan, Matteelli Alberto, Shubber Zara, Hermans Sabine, Meintjes Graeme, Grinsztejn Beatriz, Waldrop Greer, Kranzer Katharina, Doherty Meg, Getahun Haileyesus TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis Journal of the International AIDS Society 2016;19 (1):20714 [PubMed]
  • Hermans S. M., Andrews J. R., Bekker L.-G., Wood R. The mass miniature chest radiography programme in Cape Town, South Africa, 1948-1994: The impact of active tuberculosis case finding South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2016;106 (12):60-1269 [PubMed]
  • Hermans Sabine M., Grant Alison D., Chihota Violet, Lewis James J., Vynnycky Emilia, Churchyard Gavin J., Fielding Katherine L. The timing of tuberculosis after isoniazid preventive therapy among gold miners in South Africa: a prospective cohort study BMC medicine 2016;14 (1):45 [PubMed]
  • Blaser Nello, Zahnd Cindy, Hermans Sabine, Salazar-Vizcaya Luisa, Estill Janne, Morrow Carl, Egger Matthias, Keiser Olivia, Wood Robin Tuberculosis in Cape Town: An age-structured transmission model Epidemics 2016;14:54-61 [PubMed]

2015

  • Hermans Sabine, Horsburgh C. Robert, Wood Robin A Century of Tuberculosis Epidemiology in the Northern and Southern Hemisphere: The Differential Impact of Control Interventions PLoS ONE 2015;10 (8):e0135179 [PubMed]
  • Janssen Saskia, Hermans Sabine, Knap Martijn, Moekotte Alma, Rossatanga Elie G., Adegnika Akim A., Bélard Sabine, Hänscheid Thomas, Grobusch Martin P. Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon PLoS neglected tropical diseases 2015;9 (5):e0003769 [PubMed]
  • Hermans Sabine, Manabe Yukari Population-level tuberculosis incidence in the ART era Lancet infectious diseases 2015;15 (9):997-998 [PubMed]
  • Hermans Sabine, Middelkoop Keren, Wood Robin Shared locations of TB cases: places of acquisition or transmission of infection? Tropical medicine & international health 2015;20 (7):965 [PubMed]
  • Hermans Sabine, Boulle Andrew, Caldwell Judy, Pienaar David, Wood Robin Temporal trends in TB notification rates during ART scale-up in Cape Town: an ecological analysis Journal of the International AIDS Society 2015;18 (1):20240 [PubMed]

2014

  • van Leth Frank, Wit Ferdinand W. N. M., Hermans Sabine M. Antiretroviral therapy and tuberculosis: does the regimen matter? Expert review of anti-infective therapy 2014;12 (1):5-7 [PubMed]

2013

  • Hermans Sabine M., Manabe Yukari C., Kiragga Agnes N., Hoepelman Andy I. M., Lange Joep M. A., van Leth Frank Risk of tuberculosis after antiretroviral treatment initiation: a comparison between efavirenz and nevirapine using inverse probability weighting Antiviral therapy 2013;18 (4):615-622 [PubMed]

2012

  • Hermans S. M., Sempa J., Castelnuovo B., Manabe Y. C., van Leth F. Comment on: Predictors of immune recovery and the association with late mortality while on antiretroviral treatment in Cambodia Transactions of the Royal Society of Tropical Medicine and Hygiene 2012;106 (5):328-329 [PubMed]
  • Sempa Joseph, Ssennono Mark, Kuznik Andreas, Lamorde Mohammed, Sowinski Stefanie, Semeere Aggrey, Hermans Sabine, Castelnuovo Barbara, Manabe Yukari C. Cost-effectiveness of early initiation of first-line combination antiretroviral therapy in Uganda BMC public health 2012;12:736 [PubMed]
  • Hermans S. M., van Leth F., Manabe Y. C., Hoepelman A. I. M., Lange J. M. A., Kambugu A. Earlier initiation of antiretroviral therapy, increased tuberculosis case finding and reduced mortality in a setting of improved HIV care: a retrospective cohort study HIV medicine 2012;13 (6):337-344 [PubMed]
  • Kuznik Andreas, Lamorde Mohammed, Hermans Sabine, Castelnuovo Barbara, Auerbach Brandon, Semeere Aggrey, Sempa Joseph, Ssennono Mark, Ssewankambo Fred, Manabe Yukari C. Evaluating the cost-effectiveness of combination antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Uganda Bulletin of the World Health Organization 2012;90 (8):595-603 [PubMed]
  • Hermans Sabine M. HIV and tuberculosis co-infection in Uganda. Clinical management, immune reconstitution and health service deliveryUtrecht: Optima Grafische Communicatie, Rotterdam; 2012. 120p. ISBN 9789461692580. [UvA Dissertations Online] Universiteit Utrecht: Interne Geneeskunde i.h.b. de infectieziekten. (Supervisors: Hoepelman A. I. M., Lange J. M. A.; Co-supervisors: Manabe Y. C., van Leth F. C. M.)
  • Hermans Sabine, Nasuuna Esther, van Leth Frank, Byhoff Elena, Schwarz Miriam, Hoepelman Andy, Lange Joep, Manabe Yukari C. Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort study BMC public health 2012;12:674 [PubMed]
  • Hermans Sabine M., Castelnuovo Barbara, Katabira Catherine, Mbidde Peter, Lange Joep M. A., Hoepelman Andy I. M., Coutinho Alex, Manabe Yukari C. Integration of HIV and TB Services Results in Improved TB Treatment Outcomes and Earlier Prioritized ART Initiation in a Large Urban HIV Clinic in Uganda JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 2012;60 (2):E29-E35 [PubMed]
  • Manabe Yukari C., Hermans Sabine M., Lamorde Mohammed, Castelnuovo Barbara, Mullins C. Daniel, Kuznik Andreas Rifampicin for Continuation Phase Tuberculosis Treatment in Uganda: A Cost-Effectiveness Analysis PLoS ONE 2012;7 (6):e39187 [PubMed]
  • Hermans Sabine M., van Leth Frank, Kiragga Agnes N., Hoepelman Andy I. M., Lange Joep M. A., Manabe Yukari C. Unrecognised tuberculosis at antiretroviral therapy initiation is associated with lower CD4+ T cell recovery Tropical medicine & international health 2012;17 (12):1527-1533 [PubMed]

2010

  • Hermans S. M., Buys E. M. Cardiogenic shock Netherlands heart journal 2010;18 (7-8):384 [PubMed]
  • Hermans Sabine M., Kiragga Agnes N., Schaefer Petra, Kambugu Andrew, Hoepelman Andy I. M., Manabe Yukari C. Incident Tuberculosis during Antiretroviral Therapy Contributes to Suboptimal Immune Reconstitution in a Large Urban HIV Clinic in Sub-Saharan Africa PLoS ONE 2010;5 (5):e10527 [PubMed]

2004

  • Hermans S. M., Schouten W. E. M., Faber T. E., Hoepelman I. M., Andriesse G. I. Een subcutane zwelling met een maligne presentatie, maar met een infectieuze oorzaak Nederlands tijdschrift voor geneeskunde 2004;148 (33):1636-1641 [PubMed]

2001

  • Busari O. J., Vervoort M., Hermans S. M., Blom J. R. Medical education in the new millennium--a Caribbean perspective Medical education 2001;35 (7):703-706 [PubMed]
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