A. Lok MD PhD publications


Publications MD PhD A. Lok

Medical Specialist
Main activities
Patient care, Research
Biological psychiatry
Focus of research

Biological psychiatry. Mood disorders. Young adults/adolescents with depression. PTSD.

Microbiome. Inflammation.



  • Hagen Julia M., Sutterland Arjen L., Liefers Tessa, Schirmbeck Frederike, Cohn Danny M., Lok Anja, Tan Hanno L., Zwinderman Aeilko H., de Haan Lieuwe Skin autofluorescence of advanced glycation end products and mortality in affective disorders in the lifelines cohort study: A mediation analysis Journal of affective disorders 2021;282:1082-1089


  • van Amsterdam Jan G. C., Benschop Annemieke, van Binnendijk Simone, Snijder Marieke B., Lok Anja, Schene Aart H., Derks Eske M., van den Brink Wim A Comparison of Excessive Drinking, Binge Drinking and Alcohol Dependence in Ethnic Minority Groups in the Netherlands: The HELIUS Study European addiction research 2020;26 (2):66-76 [PubMed]
  • Hagen Julia M., Sutterland Arjen L., da Fonseca Pereira de Sousa Paulo A. L., Schirmbeck Frederike, Cohn Danny M., Lok Anja, Tan Hanno L., Zwinderman Aeilko H., de Haan Lieuwe Association between skin autofluorescence of advanced glycation end products and affective disorders in the lifelines cohort study Journal of affective disorders 2020;275:230-237 [PubMed]
  • Nicolaou Mary, Colpo Marco, Vermeulen Esther, Elstgeest Liset E. M., Cabout Mieke, Gibson-Smith Deborah, Knuppel Anika, Sini Giovana, Schoenaker Danielle A. J. M., Mishra Gita D., Lok Anja, Penninx Brenda W. J. H., Bandinelli Stefania, Brunner Eric J., Zwinderman Aiko H., Brouwer Ingeborg A., Visser Marjolein Association of a priori dietary patterns with depressive symptoms: A harmonised meta-analysis of observational studies Psychological medicine 2020;50 (11):1872-1883 [PubMed]
  • Bakema Maryse J., van Zuiden Mirjam, Collard Didier, Zantvoord Jasper B., de Rooij Susanne R., Elsenburg Leonie K., Snijder Marieke B., Stronks Karien, van den Born Bert-Jan H., Lok Anja Associations Between Child Maltreatment, Autonomic Regulation, and Adverse Cardiovascular Outcome in an Urban Population: The HELIUS Study Frontiers in psychiatry 2020;11 [PubMed]
  • van der Meer Christianne A. I., Bakker Anne, van Zuiden Mirjam, Lok Anja, Olff Miranda Ayuda a la mano después de eventos traumáticos: un ensayo controlado randomizado en profesionales de la salud sobre la eficacia, usabilidad y satisfacción de una aplicación de autoayuda para reducir síntomas relacionados con el trauma European journal of psychotraumatology 2020;11 (1) [PubMed]
  • Sunley Angela K., Lok Anja, White Melanie J., Snijder Marieke B., van Zuiden Mirjam, Zantvoord Jasper B., Derks Eske M. Ethnic and sex differences in the association of child maltreatment and depressed mood. The HELIUS study Child abuse & neglect 2020;99 [PubMed]
  • Scheepstra K. W. F., van Lent E. M., Lok A., Olff M., van Pampus M. G. Exploring the impact of work-related potential traumatic events among Dutch psychiatrists Psychiatry research 2020;288 [PubMed]
  • Stronks Karien, Şekercan Aydın, Snijder Marieke, Lok Anja, Verhoeff Arnoud P., Kunst Anton E., Galenkamp Henrike Higher prevalence of depressed mood in immigrants' offspring reflects their social conditions in the host country: The HELIUS study PLoS ONE 2020;15 (6):e0234006 [PubMed]
  • van der Wal Junus M., Bergfeld Isidoor O., Lok Anja, Mantione Mariska, Figee Martijn, Notten Peter, Beute Guus, Horst Ferdinand, van den Munckhof Pepijn, Schuurman P. Rick, Denys Damiaan Long-term deep brain stimulation of the ventral anterior limb of the internal capsule for treatment-resistant depression Journal of neurology, neurosurgery, and psychiatry 2020;91 (2):189-195 [PubMed]
  • Nieman Dorien H., Chavez-Baldini UnYoung, Vulink Nienke C., Smit Dirk J. A., van Wingen Guido, de Koning Pelle, Sutterland Arjen L., Mocking Roel J. T., Bockting Claudi, Verweij Karin J. H., Lok Anja, Denys Damiaan Protocol Across study: longitudinal transdiagnostic cognitive functioning, psychiatric symptoms, and biological parameters in patients with a psychiatric disorder BMC psychiatry 2020;20 (1):212 [PubMed]
  • Hagen Julia M., Sutterland Arjen L., Schirmbeck Frederike, Cohn Danny M., Lok Anja, Tan Hanno L., Zwinderman Aeilko H., de Haan Lieuwe Skin autofluorescence of advanced glycation end products and course of affective disorders in the lifelines cohort study, a prospective investigation Journal of affective disorders 2020;276:424-432 [PubMed]
  • Scheepens Dominique S., van Waarde Jeroen A., Lok Anja, de Vries Glenn, Denys Damiaan A. J. P., van Wingen Guido A. The link between structural and functional brain abnormalities in depression: A systematic review of multimodal neuroimaging studies Frontiers in psychiatry 2020;11 [PubMed]


  • ter Horst D. M., Schene A. H., Figueroa C. A., Assies J., Lok A., Bockting C. L. H., Ruhé H. G., Mocking R. J. T. Cortisol, dehydroepiandrosterone sulfate, fatty acids, and their relation in recurrent depression Psychoneuroendocrinology 2019;100:203-212 [PubMed]
  • Scheepens D. S., Van Waarde J. A., Lok A., Zantvoord J. B., De Pont B. J.H.B., Ruhé H. G., Denys D. A.J.P., Van Wingen G. A. Elektroconvulsietherapie bij persisterende depressie in Nederland; zeer lage toepassingsgraad Tijdschrift voor psychiatrie 2019;61 (1):16-21 [PubMed]
  • Thesing C. S., Lok A., Milaneschi Y., Assies J., Bockting C. L. H., Figueroa C. A., Giltay E. J., Penninx B. W. J. H., Ruhé H. G., Schene A. H., Bot M., Mocking R. J. T. Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts Acta psychiatrica Scandinavica 2019 [PubMed]
  • Zantvoord Jasper B., Ensink Judith B. M., op den Kelder Rosanne, Wessel Aimy M. A., Lok Anja, Lindauer Ramon J. L. Pretreatment cortisol predicts trauma-focused psychotherapy response in youth with (partial) posttraumatic stress disorder Psychoneuroendocrinology 2019;109 [PubMed]
  • Scheepens Dominique, van Waarde Jeroen, Lok Anja, Zantvoord Jasper, de Pont Boudewijn, Ruhé Eric, Denys Damiaan, van Wingen Guido Reactie Op Tijdschrift voor psychiatrie 2019;61 (4):287


  • Lok Anja, Frijling Jessie L., van Zuiden Mirjam Posttraumatic stress disorder: Current insights in diagnostics, treatment and prevention Nederlands tijdschrift voor geneeskunde 2018;162 (3)
  • Lok A., Frijling J. L., van Zuiden M. Posttraumatische stressstoornis Nederlands tijdschrift voor geneeskunde 2018;161:D1905 [PubMed]
  • Bergfeld Isidoor O., Mantione Mariska, Figee Martijn, Schuurman P. Richard, Lok Anja, Denys Damiaan Treatment-resistant depression and suicidality Journal of affective disorders 2018;235:362-367 [PubMed]


  • Vermeulen Esther, Stronks Karien, Snijder Marieke B., Schene Aart H., Lok Anja, de Vries Jeanne H., Visser Marjolein, Brouwer Ingeborg A., Nicolaou Mary A combined high-sugar and high-saturated-fat dietary pattern is associated with more depressive symptoms in a multi-ethnic population: the HELIUS (Healthy Life in an Urban Setting) study Public health nutrition 2017;20 (13):2374-2382 [PubMed]
  • van Zuiden Mirjam, Haverkort Sanne Q., Tan Zhonglin, Daams Joost, Lok Anja, Olff Miranda DHEA and DHEA-S levels in posttraumatic stress disorder: A meta-analytic review Psychoneuroendocrinology 2017;84:76-82 [PubMed]


  • de Vries Giel-Jan, Mocking Roel, Lok Anja, Assies Johanna, Schene Aart, Olff Miranda Fatty acid concentrations in patients with posttraumatic stress disorder compared to healthy controls Journal of affective disorders 2016;205:351-359 [PubMed]


  • de Vries Giel-Jan, Lok Anja, Mocking Roel, Assies Johanna, Schene Aart, Olff Miranda Altered one-carbon metabolism in posttraumatic stress disorder Journal of affective disorders 2015;184:277-285 [PubMed]
  • Mocking R. J. T., Pellikaan C. M., Lok A., Assies J., Ruhé H. G., Koeter M. W., Visser I., Bockting C. L., Olff M., Schene A. H. DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence? Psychoneuroendocrinology 2015;59:91-101 [PubMed]
  • Assies Johanna, Mocking Roel J. T., Lok Anja, Koeter Maarten W. J., Bockting Claudi L. H., Visser Ieke, Pouwer François, Ruhé Henricus G., Schene Aart H. Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease Psychiatry research 2015;229 (3):992-998 [PubMed]


  • Assies J., Mocking R. J. T., Lok A., Ruhé H. G., Pouwer F., Schene A. H. Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity Acta psychiatrica Scandinavica 2014;130 (3):163-180 [PubMed]
  • Lok A., Mocking R. J. T., Assies J., Koeter M. W., Bockting C. L., de Vries G. J. [=Giel-Jan], Visser I., Derks E. M., Kayser M., Schene A. H. The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state? Journal of affective disorders 2014;166:115-123 [PubMed]


  • Mocking Roel J. T., Lok Anja, Assies Johanna, Koeter Maarten W. J., Visser Ieke, Ruhé Henricus G., Bockting Claudi L. H., Schene Aart H. Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference PLoS ONE 2013;8 (12):e82980 [PubMed]
  • Lok A., Bockting C. L. H., Koeter M. W. J., Snieder H., Assies J., Mocking R. J. T., Vinkers C. H., Kahn R. S., Boks M. P., Schene A. H. Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression Translational psychiatry 2013;3:e288 [PubMed]
  • Mocking Roel J. T., Ruhé Henricus G., Assies Johanna, Lok Anja, Koeter Maarten W. J., Visser Ieke, Bockting Claudi L. H., Schene Aart H. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression Psychoneuroendocrinology 2013;38 (9):1607-1617 [PubMed]
  • Bockting C. L. H., Mocking R. J., Lok A., Koeter M. W. J., Schene A. H. Therapygenetics: the 5HTTLPR as a biomarker for response to psychological therapy? Molecular psychiatry 2013;18 (7):744-745 [PubMed]
  • Lok Anja Time after Time; biological factors in the course of recurrent depression 2013. 271p. ISBN 9789088917455. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Schene A. H., Bockting C. L. H.; Co-supervisors: Koeter M. W. J., Assies J.)


  • Mocking Roel J. T., Assies Johanna, Koeter Maarten W. J., Ruhé Henricus G., Lok Anja, Schene Aart H. Bimodal Distribution of Fatty Acids in Recurrent Major Depressive Disorder Biological psychiatry 2012;71 (1):E3-E5 [PubMed]
  • Lok Anja, Mocking Roel J. T., Ruhé Henricus G., Visser Ieke, Koeter Maarten W. J., Assies Johanna, Bockting Claudi L. H., Olff Miranda, Schene Aart H. Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression Psychoneuroendocrinology 2012;37 (7):892-902 [PubMed]
  • Bockting Claudi L. H., Lok Anja, Visser Ieke, Assies Johanna, Koeter Maarten W., Schene Aart H. Lower cortisol levels predict recurrence in remitted patients with recurrent depression: A 5.5 year prospective study Psychiatry research 2012;200 (2-3):281-287 [PubMed]
  • Mocking Roel J. T., Assies Johanna, Lok Anja, Ruhé Henricus G., Koeter Maarten W. J., Visser Ieke, Bockting Claudi L. H., Schene Aart H. Statistical Methodological Issues in Handling of Fatty Acid Data: Percentage or Concentration, Imputation and Indices Lipids 2012;47 (5):541-547 [PubMed]
  • Lok Anja, Assies Johanna, Koeter Maarten W. J., Bockting Claudi L. H., Wouters Luuk F., Mocking Roel J. T., Schene Aart H. Sustained medically unexplained physical symptoms in euthymic patients with recurrent depression: Predictive value for recurrence and associations with omega 3- and 6 fatty acids and 5-HTTLPR? Journal of affective disorders 2012;136 (3):604-611 [PubMed]


  • de Boer Jacoba, Lok Anja, van 't Verlaat Ellen, Duivenvoorden Hugo J., Bakker Arnold B., Smit Bert J. Work-related critical incidents in hospital-based health care providers and the risk of post-traumatic stress symptoms, anxiety, and depression: a meta-analysis Social science & medicine (1982) 2011;73 (2):316-326 [PubMed]


  • Assies Johanna, Pouwer François, Lok Anja, Mocking Roel J. T., Bockting Claudi L. H., Visser Ieke, Abeling Nico G. G. M., Duran Marinus, Schene Aart H. Plasma and Erythrocyte Fatty Acid Patterns in Patients with Recurrent Depression: A Matched Case-Control Study PLoS ONE 2010;5 (5):e10635 [PubMed]
  • Lok A., Visscher T. L. S., Koeter M. W. J., Assies J., Bockting C. L. H., Verschuren W. M. M., Gill A., Schene A. H. The 'Weight' of Recurrent Depression: A Comparison between Individuals with Recurrent Depression and the General Population and the Influence of Antidepressants Psychotherapy and psychosomatics 2010;79 (6):386-388 [PubMed]


  • Bermond Bob, Surachno Sugianto, Lok Anja, ten Berge Ineke J. M., Plasmans Barbara, Kox Cornelis, Schuller Esther, Schellekens Peter T. A., Hamel Ronald Memory functions in prednisone-treated kidney transplant patients Clinical transplantation 2005;19 (4):512-517 [PubMed]


  • Assies J., Lok A., Bockting C. L., Weverling G. J., Lieverse R., Visser I., Abeling N. G. G. M., Duran M., Schene A. H. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study Prostaglandins, leukotrienes, and essential fatty acids 2004;70 (4):349-356 [PubMed]


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