A.L. Oei PhD publications

foto

Publications A.L. Oei PhD

Positions
Other Academic Staff, Research Associate
Main activities
Research
Specialisation
Hyperthermia and radiobiology
Focus of research

1)  Enhancing radiotherapy or chemotherapy with DNA repair inhibiting agents, such as hyperthermia and PARP1-inhibitors. In the laboratory these sensitization effects are investigated and potential new treatment combinations are tested, both in cell lines and animal experiments. Hyperthermia is a local treatment, in which the tumour is heated up to 41- 43 C for approximately one hour. As a cancer treatment, hyperthermia should always be combined with either radiotherapy of chemotherapy; as a single therapy, hyperthermia is not effective in treating cancer. This is due to the fact that both radiotherapy (ionizing radiation) and chemotherapy induce DNA lesions. The most severe lesions are DNA double strand breaks (DSB). These DSB are repaired by two major repair pathways, Non-Homologous end-joining (NHEJ) and Homologous Recombination repair (HR). Hyperthermia treatment of 1 h at 42 C can inhibit the HR repair via a transient degradation of the BRCA2 protein which one of the major proteins of this pathway. In the laboratory we investigate the biological effects of hyperthermia in in vitro cell cultures. One of the research topics is the study of the DNA damage repair pathway. DNA repair proteins that accumulate at the sites of the DSB are studied with fluorescently labelled antibodies and studied with the fluorescence microscope. 

2) In our laboratory we also study the effects of hyperthermia (in combination treatments) on tumours infected with the human papillomavirus (HPV). From clinical studies it is known that hyperthermia is very effective on cervical cancers, of which almost all tumours are infected with HPV. In our laboratory we found that hyperthermia can disrupt the interaction between the HPV-protein E6 and tumor suppressor protein p53, which causes activite p53 resulting in more cell kill. More recently, we investigated the effects of combination treatments of radiotherapy or chemotherapy with hyperthermia and immune checkpoint inhibitors on the effectiveness on the primary tumour growth and on distant metastases (in animal models).  

3) Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is used to treat peritoneal metastases of colon cancer. In our laboratory we are focussing on developming personalized HIPEC treatment. This involves thorough investigations of different hyperthermia temperatures and durations, and various chemotherapeutic agents on multiple cell lines and mouse models.

4) Development of tests to predict normal tissue damage after radiotherapy and/or hyperthermia. Normal tissue damage after radiotherapy is a major problem in the clinic. Therefore in the lab special markers are investigated that can predict late normal tissue damage.

2020

  • Löke Daan R., Helderman Roxan F. C. P. A., Sijbrands Jan, Rodermond Hans M., Tanis Pieter J., Franken Nicolaas A. P., Oei Arlene L., Kok H. Petra, Crezee Johannes A four-inflow construction to ensure thermal stability and uniformity during hyperthermic intraperitoneal chemotherapy (HIPEC) in rats Cancers 2020;12 (12):1-14 [PubMed]
  • Agnass Pierre, Rodermond Hans M., Zweije Remko, Sijbrands Jan, Vogel Jantien A., van Lienden Krijn P., van Gulik Thomas M., van Veldhuisen Eran, Franken Nicolaas A. P., Oei Arlene L., Kok H. Petra, Besselink Marc G., Crezee Johannes Hycheed system for maintaining stable temperature control during preclinical irreversible electroporation experiments at clinically relevant temperature and pulse settings Sensors (Basel, Switzerland) 2020;20 (21):1-24 [PubMed]
  • Oei A. L., Kok H. P., Oei S. B., Horsman M. R., Stalpers L. J. A., Franken N. A. P., Crezee J. Molecular and biological rationale of hyperthermia as radio- and chemosensitizer Advanced drug delivery reviews 2020;163-164:84-97 [PubMed]
  • Mei Xionge, Cate Rosemarie Ten, van Leeuwen Caspar M., Rodermond Hans M., de Leeuw Lidewij, Dimitrakopoulou Dionysia, Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Franken Nicolaas A. P., Oei Arlene L. Radiosensitization by hyperthermia: The effects of temperature, sequence, and time interval in cervical cell lines Cancers 2020;12 (3) [PubMed]
  • Crezee Johannes, Oei Arlene L., Franken Nicolaas A. P., Stalpers Lukas J. A., Kok H. Petra Response: Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer Frontiers in oncology 2020;10 [PubMed]
  • Helderman Roxan F. C. P. A., Löke Daan R., Verhoeff Jan, Rodermond Hans M., van Bochove Gregor G. W., Boon Menno, van Kesteren Sanne, Garcia Vallejo Juan J., Kok H. Petra, Tanis Pieter J., Franken Nicolaas A. P., Crezee Johannes, Oei Arlene L. The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines Cells 2020;9 (8) [PubMed]

2019

  • Oei Arlene L., Korangath Preethi, Mulka Kathleen, Helenius Mikko, Coulter Jonathan B., Stewart Jacqueline, Velarde Esteban, Crezee Johannes, Simons Brian, Stalpers Lukas J. A., Kok H. Petra, Gabrielson Kathleen, Franken Nicolaas A. P., Ivkov Robert Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer International journal of hyperthermia 2019;36:47-63 [PubMed]
  • Elming Pernille B., Sørensen Brita S., Oei Arlene L., Franken Nicolaas A.P., Crezee Johannes, Overgaard Jens, Horsman Michael R. Hyperthermia: The optimal treatment to overcome radiation resistant hypoxia Cancers 2019;11 (1) [PubMed]
  • Sharma Anirudh, Özayral Sanem, Caserto Julia S., ten Cate Rosemarie, Anders Nicole M., Barnett James D., Kandala Sri Kamal, Henderson Elizabeth, Stewart Jacqueline, Liapi Eleni, Rudek Michelle A., Franken Nicolaas A. P., Oei Arlene L., Korangath Preethi, Bunz Fred, Ivkov Robert Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia International journal of hyperthermia 2019;36 (1):712-720 [PubMed]
  • Crezee Hans, Kok H. P., Oei Arlene L., Franken Nicolaas A. P., Stalpers Lukas J. A. The impact of the time interval between radiation and hyperthermia on clinical outcome in patients with locally advanced cervical cancer Frontiers in oncology 2019;9 (MAY) [PubMed]
  • Helderman Roxan F.C.P.A., Löke Daan R., Kok H. Petra, Oei Arlene L., Tanis Pieter J., Franken Nicolaas A.P.Klaas, Crezee Johannes Variation in clinical application of hyperthermic intraperitoneal chemotherapy: A review Cancers 2019;11 (1) [PubMed]

2018

  • Ijff Marloes, van Oorschot Bregje, Oei Arlene L., Krawczyk Przemek M., Rodermond Hans M., Stalpers Lukas J. A., Kok H. Petra, Crezee Johannes, Franken Nicolaas A. P. Enhancement of radiation effectiveness in cervical cancer cells by combining ionizing radiation with hyperthermia and molecular targeting agents International journal of molecular sciences 2018;19 (8) [PubMed]
  • Oei Arlene L., Ahire Vidhula R., van Leeuwen C. M., ten Cate Rosemarie, Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Franken Nicolaas A. P. Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i International journal of hyperthermia 2018;34 (1):39-48 [PubMed]
  • van Leeuwen C. M., Oei A. L., ten Cate R., Franken N. A. P., Bel A., Stalpers L. J. A., Crezee J., Kok H. P. Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation International journal of hyperthermia 2018;34 (1):30-38 [PubMed]
  • van Leeuwen C. M., Oei A. L., Crezee J., Bel A., Franken N. A. P., Stalpers L. J. A., Kok H. P. The alfa and beta of tumours: A review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies Radiation oncology (London, England) 2018;13 (1) [PubMed]
  • van Leeuwen C. M., Crezee J., Oei A. L., Franken N. A. P., Stalpers L. J. A., Bel A., Kok H. P. The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose International journal of hyperthermia 2018;34 (7):901-909 [PubMed]

2017

  • van Leeuwen C. M., Crezee J., Oei A. L., Franken N. A. P., Stalpers L. J. A., Bel A., Kok H. P. 3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments International journal of hyperthermia 2017;33 (2):160-169 [PubMed]
  • van Leeuwen Caspar M., Oei Arlene L., Chin Kenneth W. T. K., Crezee Johannes, Bel Arjan, Westermann Anneke M., Buist Marrije R., Franken Nicolaas A. P., Stalpers Lukas J. A., Kok H. Petra A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer Radiation oncology (London, England) 2017;12 (1):75 [PubMed]
  • Vriend Lianne E. M., van den Tempel Nathalie, Oei Arlene L., L'Acosta Mike, Pieterson Frederique J., Franken Nicolaas A. P., Kanaar Roland, Krawczyk Przemek M. Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition Oncotarget 2017;8 (57):97490-97503 [PubMed]
  • Oei Arlene L., van Leeuwen Caspar M., Ahire Vidhula R., Rodermond Hans M., ten Cate Rosemarie, Westermann Anneke M., Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Krawczyk Przemek M., Kanaar Roland, Franken Nicolaas A. P. Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia Oncotarget 2017;8 (17):28116-28124 [PubMed]
  • Oei Arlene L., Vriend Lianne E. M., van Leeuwen Caspar M., Rodermond Hans M., ten Cate Rosemarie, Westermann Anneke M., Stalpers Lukas J. A., Crezee Johannes, Kanaar Roland, Kok H. Petra, Krawczyk Przemek M., Franken Nicolaas A. P. Sensitizing thermochemotherapy with a PARP1-inhibitor Oncotarget 2017;8 (10):16303-16312 [PubMed]
  • Oei A. L., Vriend L. E. M., Krawczyk P. M., Horsman M. R., Franken N. A. P., Crezee J. Targeting therapy-resistant cancer stem cells by hyperthermia International journal of hyperthermia 2017;33 (4):419-427 [PubMed]
  • Oei Arlene L. Tumor cells can’t stand the heat: Boosting the effectiveness of hyperthermia in cervical carcinoma 2017. 299p. ISBN 9789462955103. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Medema J. P., Stalpers L. J. A.; Co-supervisors: Franken N. A. P., Kok H. P.)

2016

  • Crezee J., van Leeuwen C. M., Oei A. L., van Heerden L. E., Bel A., Stalpers L. J. A., Ghadjar P., Franken N. A. P., Kok H. P. Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer Radiation oncology (London, England) 2016;11 (1):14 [PubMed]
  • Bergs Judith W. J., Oei Arlene L., ten Cate Rosemarie, Rodermond Hans M., Stalpers Lukas J., Barendsen Gerrit W., Franken Nicolaas A. P. Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia International journal of molecular medicine 2016;38 (1):243-250 [PubMed]
  • Crezee Hans, van Leeuwen Caspar M., Oei Arlene L., Stalpers Lukas J. A., Bel Arjan, Franken Nicolaas A., Kok H. Petra Thermoradiotherapy planning: Integration in routine clinical practice International journal of hyperthermia 2016;32 (1):41-49 [PubMed]

2015

  • Oei Arlene L., Vriend Lianne E. M., Crezee Johannes, Franken Nicolaas A. P., Krawczyk Przemek M. Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all Radiation oncology (London, England) 2015;10:165 [PubMed]
  • Oei Arlene L., van Leeuwen Caspar M., ten Cate Rosemarie, Rodermond Hans M., Buist Marrije R., Stalpers Lukas J. A., Crezee Johannes, Kok H. Petra, Medema Jan Paul, Franken Nicolaas A. P. Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis Cancer research 2015;75 (23):5120-5129 [PubMed]

2014

  • van Oorschot Bregje, Oei Arlene L., Nuijens Anna C., Rodermond Hans, Hoeben Ron, Stap Jan, Stalpers Lukas J., Franken Nicolaas A. P. Decay of γ-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells Cellular & molecular biology letters 2014;19 (1):37-51 [PubMed]

2013

  • Franken Nicolaas A. P., Oei Arlene L., Kok H. Petra, Rodermond Hans M., Sminia Peter, Crezee Johannes, Stalpers Lukas J. A., Barendsen Gerrit W. Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review) International journal of oncology 2013;42 (5):1501-1515 [PubMed]

Corona-maatregelen

We zetten ons in om ons ziekenhuis veilig te houden tijdens de coronacrisis.

Lees deze extra maatregelen goed door voordat u een van onze locaties bezoekt: