I. Willuhn MSc PhD publications

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Publications MSc PhD I. Willuhn

Position
Associate Professor
Main activities
Research
Specialisation
Behavioral Neuroscience
Focus of research

I am a behavioral neuroscientist with a background in functional neuroanatomy. I am interested in how our brain controls motivated behavior and why we sometimes lose that control. My scientific focus lies on how release of the neurotransmitter dopamine (and other neuromodulators such as serotonin) regulates cortico-basal ganglia networks under normal (e.g., reinforcement learning, decision making), as well as pathological conditions (e.g., OCD, drug addiction). My research group pursues these goals by collecting a range of neurobiological measurements in awake behaving rodents (voltammetry, electrophysiology, calcium imaging etc.) and by probing neural mechanisms with optogenetic, chemogenetic, and pharmacological interventions. 

We study how the brain produces automatic and habitual actions (behavior outside of conscious control), and how dysregulation of such actions may contribute to compulsive behavior, a common denominator to several neuro-psychiatric disorders such as OCD, addictions, and eating disorders. Compulsive behavior may occur due to dysregulation of several individual behavioral functions (components), such as cognitive flexibility and habit formation. We study compulsive behavior itself, a variety of its presumed components, and their brain mechanisms in rodents, but in the long run, our research is intended to lead to novel insights that improve psychiatric therapy in human patients.  

2020

  • Robke Rhiannon, Parthasarathy Aishwarya, Willuhn Ingo, Hashemi Parastoo Electrochemical detection of serotonin release in rodentsin: Handbook of Behavioral Neuroscience. Elsevier B.V.; 2020. p. 157-174
  • Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J. J. P., Blokland Arjan, Boddeke Erik H. W. G. M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C. J. J., van Dam Anne-Marie, Deen Peter M. T., van Dijk K. W., Eggen Bart J. L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J. A. G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A. B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W. A., Kooijman Sander, Koopman Werner J. H., Korosi Aniko, Krugers Harm J., Kuiken Thijs, Kushner Steven A., Langermans Jan A. M., Lesscher Heidi M. B., Lucassen Paul J., Lutgens Esther, Netea Mihai G., Noldus Lucas P. J. J., van der Meer Jos W. M., Meye Frank J., Mul Joram D., van Oers Kees, Olivier Jocelien D. A., Pasterkamp R. Jeroen, Philippens Ingrid H. C. H. M., Prickaerts Jos, Pollux B. J. A., Rensen Patrick C. N., van Rheenen Jacco, van Rij Ronald P., Ritsma Laila, Rockx Barry.H. G., Roozendaal Benno, van Schothorst Evert M., Stittelaar K., Stockhofe Norbert, Swaab Dick F., de Swart Rik L., Vanderschuren Louk J. M. J., de Vries Taco J., de Vrij Femke, van Wezel Richard, Wierenga Corette J., Wiesmann Maximilian, Willuhn Ingo, de Zeeuw Chris I., Homberg Judith R. Erratum: How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030)) Current biology 2020;30 (21):4328 [PubMed]
  • Ehmer I., Crown L., van Leeuwen W., Feenstra M., Willuhn I., Denys D. Evidence for distinct forms of compulsivity in the SAPAP3 mutant-mouse model for obsessive-compulsive disorder eNeuro 2020;7 (2) [PubMed]
  • Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen, Blokland Arjan, Boddeke Erik H. W. G. M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C. J. J., Dam Anne-Marie van, Deen Peter M. T., van Dijk K. W., Eggen Bart J. L., Elgersma Ype, Erdogan Izel, Englitz Bernard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes, Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A. B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer J., Kersten Sander, Kiliaan Amanda J., Kooij Taco W. A., Kooijman Sander, Koopman Werner J. H., Korosi Aniko, Krugers Harm J., Kuiken Thijs, Kushner Steven A., Langermans Jan A. M., Lesscher Heidi, Lucassen Paul J., Lutgens Esther, Netea Mihai G., Noldus Lucas P. J. J., van der Meer Jos W. M., Meye Frank J., Mul Joram D., van Oers Kees, Olivier Jocelien D. A., Pasterkamp R. Jeroen, Philippens Ingrid H. C. H. M., Prickaerts Jos, Pullox Bart J. A., Rensen Patrick C. N., van Rheenen Jacco, van Rij Ronald P., Ritsma Laila, Rockx Barry.H. G., Roozendaal Benno, van Schothorst Evert M., Stittelaar K., Stockhofe Norbert, Swaab Dick F., de Swart Rik L., Vanderschuren Louk J. M. J., de Vries Taco, de Vrij Femke, van Wezel Richard, Wierenga Corette J., Wiesmann Maximilian, Willuhn Ingo, de Zeeuw Chris I., Homberg Judith R. How the COVID-19 pandemic highlights the necessity of animal research Current biology 2020;30 (18):R1014-R1018 [PubMed]
  • Ehmer I., Feenstra M., Willuhn I., Denys D. Instrumental learning in a mouse model for obsessive-compulsive disorder: Impaired habit formation in Sapap3 mutants Neurobiology of learning and memory 2020;168 [PubMed]
  • de Groot Andres, van den Boom Bastijn Jg, van Genderen Romano M., Coppens Joris, van Veldhuijzen John, Bos Joop, Hoedemaker Hugo, Negrello Mario, Willuhn Ingo, de Zeeuw Chris I., Hoogland Tycho M. NINscope, a versatile miniscope for multi-region circuit investigations eLife 2020;9 [PubMed]
  • Derksen Maik, Feenstra Matthijs, Willuhn Ingo, Denys Damiaan The serotonergic system in obsessive-compulsive disorderin: Handbook of Behavioral Neuroscience. Elsevier B.V.; 2020. p. 865-891

2019

  • Figee Martijn, Luigjes Judy, Goudriaan Anna E., Willuhn Ingo, Denys Damiaan 7 - Neurocognitive Basis of Compulsivityin: Leonardo F. Fontenelle, Murat Yücel, editors. A Transdiagnostic Approach to Obsessions, Compulsions and Related Phenomena. Cambridge University Press; 2019. p. 61-73, ISBN 9781108164313
  • van den Boom Bastijn J. G., Mooij Adriana H., Misevičiūtė Ieva, Denys Damiaan, Willuhn Ingo Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants: Impaired Pavlovian reversal learning in SAPAP3 mutants Genes, brain, and behavior 2019;18 (4):e12557 [PubMed]
  • Bazzu G., Serra P. A., Hamelink R., Feenstra M. G. P., Willuhn I., Denys D. Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice Journal of neuroscience methods 2019;317:20-28 [PubMed]

2018

  • Verharen Jeroen P. H., de Jong Johannes W., Roelofs Theresia J. M., Huffels Christiaan F. M., van Zessen Ruud, Luijendijk Mieneke C. M., Hamelink Ralph, Willuhn Ingo, den Ouden Hanneke E. M., van der Plasse Geoffrey, Adan Roger A. H., Vanderschuren Louk J. M. J. A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states Nature communications 2018;9 (1):731 [PubMed]
  • Pinhal Cindy M., van den Boom Bastijn J. G., Santana-Kragelund Fabiana, Fellinger Lizz, Bech Pol, Hamelink Ralph, Feng Guoping, Willuhn Ingo, Feenstra Matthijs G. P., Denys Damiaan Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice Biological psychiatry 2018;84 (12):917-925 [PubMed]

2017

  • van den Boom Bastijn J. G., Pavlidi Pavlina, Wolf Casper M. H., Mooij Hanne A. H., Willuhn Ingo Automated classification of self-grooming in mice using open-source software Journal of neuroscience methods 2017;289:48-56 [PubMed]
  • Klanker Marianne, Feenstra Matthijs, Willuhn Ingo, Denys Damiaan DEEP BRAIN STIMULATION OF THE MEDIAL FOREBRAIN BUNDLE ELEVATES STRIATAL DOPAMINE CONCENTRATION WITHOUT AFFECTING SPONTANEOUS OR REWARD-INDUCED PHASIC RELEASE Neuroscience 2017;364:82-92 [PubMed]
  • Burgeno Lauren M. Diametric Changes in Ventral Striatal Dopamine Release Regulate Drug-Taking and Drug-Seeking Behavior 2017. 158p. [UvA Dissertations Online] University of Washington (Seattle, WA, USA): Department of Pharmacology. (Supervisor: Philips P. E. M.; Co-supervisor: Willuhn I.)
  • Vulink Nienke, Willuhn Ingo, van Elzelingen Wouter Influence of Sex Hormones on OCDin: Christopher Pittenger, editors. Obsessive-compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. Oxford University Press; 2017., ISBN 9780190228163
  • Klanker Marianne, Fellinger Lisanne, Feenstra Matthijs, Willuhn Ingo, Denys Damiaan Regionally distinct phasic dopamine release patterns in the striatum during reversal learning Neuroscience 2017;345:110-123 [PubMed]

2016

  • Figee Martijn, Pattij Tommy, Willuhn Ingo, Luigjes Judy, van den Brink Wim, Goudriaan Anneke, Potenza Marc N., Robbins Trevor W., Denys Damiaan Compulsivity in obsessive-compulsive disorder and addictions European neuropsychopharmacology 2016;26 (5):856-868 [PubMed]
  • Klanker Marianne Neuromodulation in corticostriatal circuits: On deep brain stimulation and dopamine 2016. 182p. ISBN 9789402801705. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Denys D. A. J. P.; Co-supervisors: Feenstra M. G. P., Willuhn I.)

2015

  • Klanker Marianne, Sandberg Tessa, Joosten Ruud, Willuhn Ingo, Feenstra Matthijs, Denys Damiaan Phasic dopamine release induced by positive feedback predicts individual differences in reversal learning Neurobiology of learning and memory 2015;125:135-145 [PubMed]
  • Groblewski Peter A., Zietz Chad, Willuhn Ingo, Phillips Paul E. M., Chavkin Charles Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats Addiction biology 2015;20 (2):297-301 [PubMed]

2014

  • Willuhn Ingo, Burgeno Lauren M., Groblewski Peter A., Phillips Paul E. M. Excessive cocaine use results from decreased phasic dopamine signaling in the striatum Nature neuroscience 2014;17 (5):704-709 [PubMed]
  • Willuhn Ingo, Tose Amanda, Wanat Matthew J., Hart Andrew S., Hollon Nick G., Phillips Paul E. M., Schwarting Rainer K. W., Wöhr Markus Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats Journal of neuroscience 2014;34 (32):10616-10623 [PubMed]

2012

  • Willuhn Ingo, Burgeno Lauren M., Everitt Barry J., Phillips Paul E. M. Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use Proceedings of the National Academy of Sciences of the United States of America 2012;109 (50):20703-20708 [PubMed]

2011

  • Flagel Shelly B., Clark Jeremy J., Robinson Terry E., Mayo Leah, Czuj Alayna, Willuhn Ingo, Akers Christina A., Clinton Sarah M., Phillips Paul E. M., Akil Huda A selective role for dopamine in stimulus-reward learning Nature 2011;469 (7328):53-57 [PubMed]

2010

  • Clark Jeremy J., Sandberg Stefan G., Wanat Matthew J., Gan Jerylin O., Horne Eric A., Hart Andrew S., Akers Christina A., Parker Jones G., Willuhn Ingo, Martinez Vicente, Evans Scott B., Stella Nephi, Phillips Paul E. M. Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals Nature methods 2010;7 (2):126-129 [PubMed]
  • Willuhn Ingo, Wanat Matthew J., Clark Jeremy J., Phillips Paul E. M. Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse Current topics in behavioral neurosciences 2010;3:29-71 [PubMed]
  • Ondracek Janie M., Willuhn Ingo, Steiner Heinz, West Anthony R. Interactions between Procedural Learning and Cocaine Exposure Alter Spontaneous and Cortically Evoked Spike Activity in the Dorsal Striatum Frontiers in neuroscience 2010;4:206 [PubMed]

2009

  • Unal Cagri T., Beverley Joel A., Willuhn Ingo, Steiner Heinz Long-lasting dysregulation of gene expression in corticostriatal circuits after repeated cocaine treatment in adult rats: effects on zif 268 and homer 1a European journal of neuroscience 2009;29 (8):1615-1626 [PubMed]
  • Wanat Matthew J., Willuhn Ingo, Clark Jeremy J., Phillips Paul E. M. Phasic dopamine release in appetitive behaviors and drug addiction Current drug abuse reviews 2009;2 (2):195-213 [PubMed]
  • Willuhn Ingo, Steiner Heinz Skill-memory consolidation in the striatum: critical for late but not early long-term memory and stabilized by cocaine Behavioural brain research 2009;199 (1):103-107 [PubMed]

2008

  • Tropea Thomas F., Guerriero Réjean M., Willuhn Ingo, Unterwald Ellen M., Ehrlich Michelle E., Steiner Heinz, Kosofsky Barry E. Augmented D1 dopamine receptor signaling and immediate-early gene induction in adult striatum after prenatal cocaine Biological psychiatry 2008;63 (11):1066-1074 [PubMed]
  • Willuhn I., Steiner H. Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatum Neuroscience 2008;153 (1):249-258 [PubMed]

2007

  • Topic B., Willuhn I., Palomero-Gallagher N., Zilles K., Huston J. P., Hasenöhrl R. U. Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus Hippocampus 2007;17 (1):68-77 [PubMed]

2006

  • Willuhn Ingo, Steiner Heinz Motor-skill learning-associated gene regulation in the striatum: effects of cocaine Neuropsychopharmacology 2006;31 (12):2669-2682 [PubMed]

2003

  • Willuhn Ingo, Sun Weiwen, Steiner Heinz Topography of cocaine-induced gene regulation in the rat striatum: relationship to cortical inputs and role of behavioural context European journal of neuroscience 2003;17 (5):1053-1066 [PubMed]

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