J.J.B. Koster PhD publications

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Publications J.J.B. Koster PhD

Positions
Associate Professor, Research Associate
Main activities
Research
Specialisation
bioinformatics, genomics, high-throughput analyses
Focus of research

Overall goal

Development of a dedicated bioinformatics platform, loaded with tools and methods which allow wetlab biologists to interpret their own high-throughput experiments (mircoarray data,chip on chip, whole genome sequencing). 

Reaching this goal

R2 is our in house developed web-based bioinformatics analysis and visualization platform that enables analysis of probable targets in the context of (tumor) microarray data (url: http://r2.amc.nl). Specifically focusing at biologists, R2 aids in the analysis and visualization of microarray data (tumor series, experiments) and their annotated features (such as clinical information). R2 contains an expanding set of analyses which are heavily inter-connected, allowing users to quickly hop from one view (representation of the data) to another. Currently R2 supports all major chip designs for human, mouse and rat and harbors nearly 30.000 microarray samples (divided over more than 250 datasets). R2 is also being employed in the integration, analysis and visualization of aCGH / ChIP on chip / Whole genome sequence information.

Public use of the project results

The main research-objective of our group is the fast translation of probable drug targets for childhood tumors from the wet-lab to the clinic. The tools developed are used to determine these targets.

2020

  • Narayan Ravi S., Molenaar Piet, Teng Jian, Cornelissen Fleur M. G., Roelofs Irene, Menezes Renee, Dik Rogier, Lagerweij Tonny, Broersma Yoran, Petersen Naomi, Marin Soto Jhon Alexander, Brands Eelke, van Kuiken Philip, Lecca Maria C., Lenos Kristiaan J., in ‘t Veld Sjors G. J. G., van Wieringen Wessel, Lang Frederick F., Sulman Erik, Verhaak Roel, Baumert Brigitta G., Stalpers Lucas J. A., Vermeulen Louis, Watts Colin, Bailey David, Slotman Ben J., Versteeg Rogier, Noske David, Sminia Peter, Tannous Bakhos A., Wurdinger Tom, Koster Jan, Westerman Bart A. A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities Nature communications 2020;11 (1) [PubMed]
  • Montenegro-Miranda Paula S., van der Meer Jonathan H. M., Jones Christine, Meisner Sander, Vermeulen Jacqueline L. M., Koster Jan, Wildenberg Manon E., Heijmans Jarom, Boudreau Francois, Ribeiro Agnes, van den Brink Gijs R., Muncan Vanesa A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration Cellular and molecular gastroenterology and hepatology 2020;10 (2):209-223 [PubMed]
  • Bernink Jochem H., Ohne Yoichiro, Teunissen Marcel B. M., Wang Jingya, Wu Jincheng, Krabbendam Lisette, Guntermann Christine, Volckmann Richard, Koster Jan, van Tol Sophie, Ramirez Ivan, Shrestha Yashaswi, de Rie Menno A., Spits Hergen, Ros Xavier Romero, Humbles Alison A. Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies (Nature Immunology, (2019), 20, 8, (992-1003), 10.1038/s41590-019-0423-0) Nature immunology 2020;21 (1):101 [PubMed]
  • Meel Michaël H., de Gooijer Mark C., Metselaar Dennis S., Sewing A. Charlotte P., Zwaan Kenn, Waranecki Piotr, Breur Marjolein, Buil Levi C. M., Lagerweij Tonny, Wedekind Laurine E., Twisk Jos W. R., Koster Jan, Hashizume Rintaro, Raabe Eric H., Montero Carcaboso Ángel, Bugiani Marianna, Phoenix Timothy N., van Tellingen Olaf, van Vuurden Dannis G., Kaspers Gertjan J. L., Hulleman Esther Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma Clinical cancer research 2020;26 (13):3319-3332 [PubMed]
  • Kavazović Inga, Han Hongya, Balzaretti Giulia, Slinger Erik, Lemmermann Niels A. W., ten Brinke Anja, Merkler Doron, Koster Jan, Bryceson Yenan T., de Vries Niek, Jonjić Stipan, Klarenbeek Paul L., Polić Bojan, Eldering Eric, Wensveen Felix M. Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity PLoS biology 2020;18 (3):e3000648 [PubMed]
  • Meel Michaël H., Guillén Navarro Miriam, de Gooijer Mark C., Metselaar Dennis S., Waranecki Piotr, Breur Marjolein, Lagerweij Tonny, Wedekind Laurine E., Koster Jan, van de Wetering Marianne D., Schouten-van Meeteren Netteke, Aronica Eleonora, van Tellingen Olaf, Bugiani Marianna, Phoenix Timothy N., Kaspers Gertjan J. L., Hulleman Esther MEK/MELK inhibition and blood-brain barrier deficiencies in atypical teratoid/rhabdoid tumors Neuro-oncology 2020;22 (1):58-69 [PubMed]
  • Avitabile Marianna, Succoio Mariangela, Testori Alessandro, Cardinale Antonella, Vaksman Zalman, Lasorsa Vito Alessandro, Cantalupo Sueva, Esposito Matteo, Cimmino Flora, Montella Annalaura, Formicola Daniela, Koster Jan, Andreotti Virginia, Ghiorzo Paola, Romano Maria Fiammetta, Staibano Stefania, Scalvenzi Massimiliano, Ayala Fabrizio, Hakonarson Hakon, Corrias Maria Valeria, Devoto Marcella, Law Matthew H., Iles Mark M., Brown Kevin, Diskin Sharon, Zambrano Nicola, Iolascon Achille, Capasso Mario Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene Carcinogenesis 2020;41 (3):284-295 [PubMed]
  • Schubert Nil A., Lowery Caitlin D., Bergthold Guillaume, Koster Jan, Eleveld Thomas F., Rodríguez Ana, Jones David T. W., Vassal Gilles, Stancato Louis F., Pfister Stefan M., Caron Hubert N., Molenaar Jan J. Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers European journal of cancer (Oxford, England 2020;130:168-181 [PubMed]
  • Dijk Frederike, Veenstra Veronique L., Soer Eline C., Dings Mark P. G., Zhao Lan, Halfwerk Johannes B., Hooijer Gerrit K., Damhofer Helene, Marzano Marco, Steins Anne, Waasdorp Cynthia, Busch Olivier R., Besselink Marc G., Tol Johanna A., Welling Lieke, van Rijssen Lennart B., Klompmaker Sjors, Wilmink Hanneke W., van Laarhoven Hanneke W., Medema Jan Paul, Vermeulen Louis, van Hooff Sander R., Koster Jan, Verheij Joanne, van de Vijver Marc J., Wang Xin, Bijlsma Maarten F. Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems Scientific reports 2020;10 (1):337 [PubMed]

2019

  • Koster Jan, Plasterk Ronald H. A. A library of Neo Open Reading Frame peptides (NOPs) as a sustainable resource of common neoantigens in up to 50% of cancer patients Scientific reports 2019;9 (1) [PubMed]
  • van Groningen Tim, Akogul Nurdan, Westerhout Ellen M., Chan Alvin, Hasselt Nancy E., Zwijnenburg Danny A., Broekmans Marloes, Stroeken Peter, Haneveld Franciska, Hooijer Gerrit K. J., Savci-Heijink C. Dilara, Lakeman Arjan, Volckmann Richard, van Sluis Peter, Valentijn Linda J., Koster Jan, Versteeg Rogier, van Nes Johan A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma Nature communications 2019;10 (1):1530 [PubMed]
  • Savci-Heijink C. D., Halfwerk H., Koster J., Horlings H. M., van de Vijver M. J. A specific gene expression signature for visceral organ metastasis in breast cancer BMC cancer 2019;19 (1):333 [PubMed]
  • Georgescu Constantin, Corbin Joshua M., Thibivilliers Sandra, Webb Zachary D., Zhao Yan D., Koster Jan, Fung Kar-Ming, Asch Adam S., Wren Jonathan D., Ruiz-Echevarría Maria J. A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer BMC cancer 2019;19 (1):423 [PubMed]
  • Lange Ingo, Koster Jan, Koomoa Dana-Lynn T. Calcium signaling regulates fundamental processes involved in Neuroblastoma progression Cell Calcium 2019;82:102052 [PubMed]
  • Metselaar Dennis S., Meel Michaël H., Benedict Bente, Waranecki Piotr, Koster Jan, Kaspers Gertjan J. L., Hulleman Esther Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin EBioMedicine 2019;50:81-92 [PubMed]
  • Bernink Jochem H., Ohne Yoichiro, Teunissen Marcel B. M., Wang Jingya, Wu Jincheng, Krabbendam Lisette, Guntermann Christine, Volckmann Richard, Koster Jan, van Tol Sophie, Ramirez Ivan, Shrestha Yashaswi, de Rie Menno A., Spits Hergen, Romero Ros Xavier, Humbles Alison A. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nature immunology 2019;20 (8):992-1003 [PubMed]
  • Karpus Olga N, Westendorp B Florien, Vermeulen Jacqueline L M, Meisner Sander, Koster Jan, Muncan Vanesa, Wildenberg Manon E, van den Brink Gijs R Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth Cell reports 2019;26 (13):3698-3708.e5 [PubMed]
  • Nederlof Iris, de Bortoli Davide, Bareche Yacine, Nguyen Bastien, de Maaker Michiel, Hooijer Gerrit K. J., Buisseret Laurence, Kok Marleen, Smid Marcel, van den Eynden Gert G. G. M., Brinkman Arie B., Hudecek Jan, Koster Jan, Sotiriou Christos, Larsimont Denis, Martens John W. M., van de Vijver Marc J., Horlings Hugo M., Salgado Roberto, Biganzoli Elia, Desmedt Christine Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer Breast cancer research 2019;21 (1) [PubMed]
  • Savci-Heijink C. D., Halfwerk H., Hooijer G. K. J., Koster J., Horlings H. M., Meijer S. L., van de Vijver M. J. Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior Breast cancer research and treatment 2019;174 (3):649-659 [PubMed]
  • van Kuilenburg A. B. P., Tarailo-Graovac M., Richmond P. A., Drögemöller B. I., Pouladi M. A., Leen R., Brand-Arzamendi K., Dobritzsch D., Dolzhenko E., Eberle M. A., Hayward B., Jones M. J., Karbassi F., Kobor M. S., Koster J., Kumari D., Li M., MacIsaac J., McDonald C., Meijer J., Nguyen C., Rajan-Babu I. S., Scherer S. W., Sim B., Trost B., Tseng L. A., Turkenburg M., van Vugt J. J. F. A., Veldink J. H., Walia J. S., Wang Y., van Weeghel M., Wright G. E. B., Xu X., Yuen R. K. C., Zhang J., Ross C. J., Wasserman W. W., Geraghty M. T., Santra S., Wanders R. J. A., Wen X. Y., Waterham H. R., Usdin K., van Karnebeek C. D. M. Glutaminase deficiency caused by short tandem repeat expansion in GLS New England journal of medicine 2019;380 (15):1433-1441 [PubMed]
  • Ravi Abilash, Koster Jan, Dijkhuis Annemiek, Bal Suzanne M., Sabogal Piñeros Yanaika S., Bonta Peter I., Majoor Christof J., Sterk Peter J., Lutter René Interferon-induced epithelial response to rhinovirus 16 in asthma relates to inflammation and FEV1 Journal of allergy and clinical immunology 2019;143 (1):442-447.e10 [PubMed]
  • van Wezel Esther M. , van Zogchel Lieke M. J. , van Wijk Jalenka, Timmerman Ilse, Vo Ngoc-Kim, Zappeij-Kannegieter Lily, deCarolis Boris, Simon Thorsten, van Noesel Max, Molenaar Jan J. , van Groningen Tim, Versteeg Rogier, Caron Huib N. , van der Schoot C. Ellen, Koster Jan, van Nes Johan, Tytgat Godelieve Mesenchymal Neuroblastoma Cells Are Undetected by Current mRNA Marker Panels: The Development of a Specific Neuroblastoma Mesenchymal Minimal Residual Disease Panel JCO Precision Oncology 2019
  • Herold Steffi, Kalb Jacqueline, Büchel Gabriele, Ade Carsten P., Baluapuri Apoorva, Xu Jiajia, Koster Jan, Solvie Daniel, Carstensen Anne, Klotz Christina, Rodewald Sabrina, Schülein-Völk Christina, Dobbelstein Matthias, Wolf Elmar, Molenaar Jan, Versteeg Rogier, Walz Susanne, Eilers Martin Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase Nature 2019;567 (7749):545-549 [PubMed]
  • Lambo Sander, Gröbner Susanne N., Rausch Tobias, Waszak Sebastian M., Schmidt Christin, Gorthi Aparna, Romero July Carolina, Mauermann Monika, Brabetz Sebastian, Krausert Sonja, Buchhalter Ivo, Koster Jan, Zwijnenburg Danny A., Sill Martin, Hübner Jens-Martin, Mack Norman, Schwalm Benjamin, Ryzhova Marina, Hovestadt Volker, Papillon-Cavanagh Simon, Chan Jennifer A., Landgraf Pablo, Ho Ben, Milde Till, Witt Olaf, Ecker Jonas, Sahm Felix, Sumerauer David, Ellison David W., Orr Brent A., Darabi Anna, Haberler Christine, Figarella-Branger Dominique, Wesseling Pieter, Schittenhelm Jens, Remke Marc, Taylor Michael D., Gil-da-Costa Maria J., Łastowska Maria, Grajkowska Wiesława, Hasselblatt Martin, Hauser Peter, Pietsch Torsten, Uro-Coste Emmanuelle, Bourdeaut Franck, Masliah-Planchon Julien, Rigau Valérie, Alexandrescu Sanda, Wolf Stephan, Li Xiao-Nan, Schüller Ulrich, Snuderl Matija, Karajannis Matthias A., Giangaspero Felice, Jabado Nada, von Deimling Andreas, Jones David T. W., Korbel Jan O., von Hoff Katja, Lichter Peter, Huang Annie, Bishop Alexander J. R., Pfister Stefan M., Korshunov Andrey, Kool Marcel The molecular landscape of ETMR at diagnosis and relapse Nature 2019;576 (7786):274-280 [PubMed]

2018

  • Brabetz Sebastian, Leary Sarah E. S., Gröbner Susanne N., Nakamoto Madison W., Şeker-Cin Huriye, Girard Emily J., Cole Bonnie, Strand Andrew D., Bloom Karina L., Hovestadt Volker, Mack Norman L., Pakiam Fiona, Schwalm Benjamin, Korshunov Andrey, Balasubramanian Gnana Prakash, Northcott Paul A., Pedro Kyle D., Dey Joyoti, Hansen Stacey, Ditzler Sally, Lichter Peter, Chavez Lukas, Jones David T. W., Koster Jan, Pfister Stefan M., Kool Marcel, Olson James M. A biobank of patient-derived pediatric brain tumor models Nature medicine 2018;24 (11):1752-1761 [PubMed]
  • Agarwal Saurabh, Milazzo Giorgio, Rajapakshe Kimal, Bernardi Ronald, Chen Zaowen, Eveline Barbieri, Koster Jan, Perini Giovanni, Coarfa Cristian, Shohet Jason M. Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma [Oncotarget., 9, (2018) (20323-20338)] doi 10.18632/oncotarget.24859 Oncotarget 2018;9 (52):30024-30024 [PubMed]
  • Gröbner Susanne N., Worst Barbara C., Weischenfeldt Joachim, Buchhalter Ivo, Kleinheinz Kortine, Rudneva Vasilisa A., Johann Pascal D., Balasubramanian Gnana Prakash, Segura-Wang Maia, Brabetz Sebastian, Bender Sebastian, Hutter Barbara, Sturm Dominik, Pfaff Elke, Hübschmann Daniel, Zipprich Gideon, Heinold Michael, Eils J. rgen, Lawerenz Christian, Erkek Serap, Lambo Sander, Waszak Sebastian, Blattmann Claudia, Borkhardt Arndt, Kuhlen Michaela, Eggert Angelika, Fulda Simone, Gessler Manfred, Wegert Jenny, Kappler Roland, Baumhoer Daniel, Burdach Stefan, Kirschner-Schwabe Renate, Kontny Udo, Kulozik Andreas E., Lohmann Dietmar, Hettmer Simone, Eckert Cornelia, Bielack Stefan, Nathrath Michaela, Niemeyer Charlotte, Richter G. nther H., Schulte Johannes, Siebert Reiner, Westermann Frank, Molenaar Jan J., Vassal Gilles, Witt Hendrik, Burkhardt Birgit, Kratz Christian P., Witt Olaf, van Tilburg Cornelis M., Kramm Christof M., Fleischhack Gudrun, Dirksen Uta, Rutkowski Stefan, Frühwald Michael, von Hoff Katja, Wolf Stephan, Klingebiel Thomas, Koscielniak Ewa, Landgraf Pablo, Koster Jan, Resnick Adam C., Zhang Jinghui, Liu Yanling, Zhou Xin, Waanders Angela J., Zwijnenburg Danny A., Raman Pichai, Brors Benedikt, Weber Ursula D., Northcott Paul A., Pajtler Kristian W., Kool Marcel, Piro Rosario M., Korbel Jan O., Schlesner Matthias, Eils Roland, Jones David T. W., Lichter Peter, Chavez Lukas, Zapatka Marc, Pfister Stefan M. Correction: The landscape of genomic alterations across childhood cancers (Nature (2018) DOI: 10.1038/nature25480) Nature 2018;559 (7714):E10 [PubMed]
  • Rajbhandari Presha, Lopez Gonzalo, Capdevila Claudia, Salvatori Beatrice, Yu Jiyang, Rodriguez-Barrueco Ruth, Martinez Daniel, Yarmarkovich Mark, Weichert-Leahey Nina, Abraham Brian J., Alvarez Mariano J., Iyer Archana, Harenza Jo Lynne, Oldridge Derek, de Preter Katleen, Koster Jan, Asgharzadeh Shahab, Seeger Robert C., Wei Jun S., Khan Javed, Vandesompele Jo, Mestdagh Pieter, Versteeg Rogier, Look A. Thomas, Young Richard A., Iavarone Antonio, Lasorella Anna, Silva Jose M., Maris John M., Califano Andrea Cross-cohort analysis identifies a TEAD4–MYCN positive feedback loop as the core regulatory element of high-risk neuroblastoma Cancer discovery 2018;8 (5):582-599 [PubMed]
  • Cimmino Flora, Avitabile Marianna, Diskin Sharon J., Vaksman Zalman, Pignataro Piero, Formicola Daniela, Cardinale Antonella, Testori Alessandro, Koster Jan, de Torres Carmen, Devoto Marcella, Maris John M., Iolascon Achille, Capasso Mario Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor International journal of cancer. Journal international du cancer 2018;143 (11):2828-2837 [PubMed]
  • Depuydt Pauline, Boeva Valentina, Hocking Toby D., Cannoodt Robrecht, Ambros Inge M., Ambros Peter F., Asgharzadeh Shahab, Attiyeh Edward F., Combaret Valérie, Defferrari Raffaella, Fischer Matthias, Hero Barbara, Hogarty Michael D., Irwin Meredith S., Koster Jan, Kreissman Susan, Ladenstein Ruth, Lapouble Eve, Laureys Geneviève, London Wendy B., Mazzocco Katia, Nakagawara Akira, Noguera Rosa, Ohira Miki, Park Julie R., Pötschger Ulrike, Theissen Jessica, Tonini Gian Paolo, Valteau-Couanet Dominique, Varesio Luigi, Versteeg Rogier, Speleman Frank, Maris John M., Schleiermacher Gudrun, de Preter Katleen Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients Journal of the National Cancer Institute 2018;110 (10):1084-1093 [PubMed]
  • Ménard Marie, Costechareyre Clélia, Ichim Gabriel, Blachier Jonathan, Neves David, Jarrosson-Wuilleme Loraine, Depping Reinhard, Koster Jan, Saintigny Pierre, Mehlen Patrick, Tauszig-Delamasure Servane Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth PLoS biology 2018;16 (5) [PubMed]
  • Westendorp B. Florien, Büller Nikè V. J. A., Karpus Olga N., van Dop Willemijn A., Koster Jan, Versteeg Rogier, Koelink Pim J., Snel Clinton Y., Meisner Sander, Roelofs Joris J. T. H., Uhmann Anja, Ver Loren van Themaat Emiel, Heijmans Jarom, Hahn Heidi, Muncan Vanesa, Wildenberg Manon E., van den Brink Gijs R. Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response Cellular and molecular gastroenterology and hepatology 2018;5 (1):67-82.e1 [PubMed]
  • Trumpi Kari, Frenkel Nicola, Peters Timo, Korthagen Nicoline M., Jongen Jennifer M. J., Raats Daniëlle, van Grevenstein Helma, Backes Yara, Moons Leon M., Lacle Miangela M., Koster Jan, Zwijnenburg Danny, Rinkes Inne H. M. Borel, Kranenburg Onno Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions Oncotarget 2018;9 (28):19490-19507 [PubMed]
  • Bruggeman Jan Willem, Koster Jan, Lodder Paul, Repping Sjoerd, Hamer Geert Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development Oncogene 2018;37 (42):5694-5700 [PubMed]
  • Meel Michael H., de Gooijer Mark C., Navarro Miriam Guillen, Waranecki Piotr, Breur Marjolein, Buil Levi C. M., Wedekind Laurine E., Twisk Jos W. R., Koster Jan, Hashizume Rintaro, Raabe Eric H., Carcaboso Angel Montero, Bugiani Marianna, van Tellingen Olaf, van Vuurden Dannis G., Kaspers Gertjan J. L., Hulleman Esther MeLK inhibition in diffuse intrinsic pontine glioma Clinical cancer research 2018;24 (22):5645-5657 [PubMed]
  • Depuydt Pauline, Koster Jan, Boeva Valentina, Hocking Toby D., Speleman Frank, Schleiermacher Gudrun, de Preter Katleen Meta-mining of copy number profiles of high-risk neuroblastoma tumors Scientific data 2018;5 [PubMed]
  • Agarwal Saurabh, Milazzo Giorgio, Rajapakshe Kimal, Bernardi Ronald, Chen Zaowen, Barberi Eveline, Koster Jan, Perini Giovanni, Coarfa Cristian, Shohet Jason M. MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma Oncotarget 2018;9 (29):20323-20338 [PubMed]
  • Braekeveldt Noémie, von Stedingk Kristoffer, Fransson Susanne, Martinez-Monleon Angela, Lindgren David, Axelson H. kan, Levander Fredrik, Willforss Jakob, Hansson Karin, Øra Ingrid, Backman Torbjörn, Börjesson Anna, Beckman Siv, Esfandyari Javanshir, Berbegall Ana P., Noguera Rosa, Karlsson Jenny, Koster Jan, Martinsson Tommy, Gisselsson David, Påhlman Sven, Bexell Daniel Patient-derived xenograft models reveal intratumor heterogeneity and temporal stability in neuroblastoma Cancer research 2018;78 (20):5958-5969 [PubMed]
  • van den Eynden Jimmy, Umapathy Ganesh, Ashouri Arghavan, Cervantes-Madrid Diana, Szydzik Joanna, Ruuth Kristina, Koster Jan, Larsson Erik, Guan Jikui, Palmer Ruth H., Hallberg Bengt Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways Science signaling 2018;11 (557) [PubMed]
  • Eleveld Thomas F., Schild Linda, Koster Jan, Zwijnenburg Danny A., Alles Lindy K., Ebus Marli E., Volckmann Richard, Tijtgat Godelieve A., van Sluis Peter, Versteeg Rogier, Molenaar Jan J. RaS–MAPK pathway-driven tumor progression is associated with loss of CIC and other genomic aberrations in neuroblastoma Cancer research 2018;78 (21):6297-6307 [PubMed]
  • Schultz Chad R., Geerts Dirk, Mooney Marie, El-Khawaja Raid, Koster Jan, Bachmann André S. Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma Biochemical journal 2018;475 (2):531-545 [PubMed]
  • Gröbner Susanne N., Worst Barbara C., Weischenfeldt Joachim, Buchhalter Ivo, Kleinheinz Kortine, Rudneva Vasilisa A., Johann Pascal D., Balasubramanian Gnana Prakash, Segura-Wang Maia, Brabetz Sebastian, Bender Sebastian, Hutter Barbara, Sturm Dominik, Pfaff Elke, Hübschmann Daniel, Zipprich Gideon, Heinold Michael, Eils Jürgen, Lawerenz Christian, Erkek Serap, Lambo Sander, Waszak Sebastian, Blattmann Claudia, Borkhardt Arndt, Kuhlen Michaela, Eggert Angelika, Fulda Simone, Gessler Manfred, Wegert Jenny, Kappler Roland, Baumhoer Daniel, Burdach Stefan, Kirschner-Schwabe Renate, Kontny Udo, Kulozik Andreas E., Lohmann Dietmar, Hettmer Simone, Eckert Cornelia, Bielack Stefan, Nathrath Michaela, Niemeyer Charlotte, Richter Günther H., Schulte Johannes, Siebert Reiner, Westermann Frank, Molenaar Jan J., Vassal Gilles, Koster Jan, Zwijnenburg Danny A., Kool Marcel The landscape of genomic alterations across childhood cancers Nature 2018;555:321-327 [PubMed]
  • Groß Anja S., Schulz Catrine, Kolb Jasmine, Koster Jan, Wehner Sibylle, Czaplinski Sebastian, Khilan Abdulghani, Rohrer Hermann, Harter Patrick N., Klingebiel Thomas, Langer Julian D., Geerts Dirk, Schulte Dorothea Tumorigenic and anti-proliferative properties of the TALE-transcription factors MEIS2D and MEIS2A in neuroblastoma Cancer research 2018;78 (8):1935-1947 [PubMed]

2017

  • Moreno Lucas, Caron Hubert, Geoerger Birgit, Eggert Angelika, Schleiermacher Gudrun, Brock Penelope, Valteau-Couanet Dominique, Chesler Louis, Schulte Johannes H., de Preter Katleen, Molenaar Jan, Schramm Alexander, Eilers Martin, van Maerken Tom, Johnsen John Inge, Garrett Michelle, George Sally L., Tweddle Deborah A., Kogner Per, Berthold Frank, Koster Jan, Barone Giuseppe, Tucker Elizabeth R., Marshall Lynley, Herold Ralf, Sterba Jaroslav, Norga Koen, Vassal Gilles, Pearson Andrew D. J. Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project Expert opinion on drug discovery 2017;12 (8):801-811 [PubMed]
  • Savci-Heijink Cemile Dilara, Halfwerk Hans, Koster Jan, van de Vijver Marc Joan Association between gene expression profile of the primary tumor and chemotherapy response of metastatic breast cancer BMC cancer 2017;17 (1):755 [PubMed]
  • Meel Michaël H., Sewing A. Charlotte P., Waranecki Piotr, Metselaar Dennis S., Wedekind Laurine E., Koster Jan, van Vuurden Dannis G., Kaspers Gertjan J. L., Hulleman Esther Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies Experimental cell research 2017;360 (2):397-403 [PubMed]
  • Bate-Eya Laurel T., Gierman Hinco J., Ebus Marli E., Koster Jan, Caron Huib N., Versteeg Rogier, Dolman M. Emmy M., Molenaar Jan J. Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity European journal of cancer (Oxford, England 2017;75:63-72 [PubMed]
  • Panosyan Eduard H., Lin Henry J., Koster Jan, Lasky Joseph L. In search of druggable targets for GBM amino acid metabolism BMC cancer 2017;17 (1):162 [PubMed]
  • Russo Roberta, Cimmino Flora, Pezone Lucia, Manna Francesco, Avitabile Marianna, Langella Concetta, Koster Jan, Casale Fiorina, Raia Maddalena, Viola Giampietro, Fischer Matthias, Iolascon Achille, Capasso Mario Kinome expression profiling of human neuroblastoma tumors identifies potential drug targets for ultra high-risk patients Carcinogenesis 2017;38 (10):1011-1020 [PubMed]
  • Zhao Jing, Hakvoort Theodorus B. M., Ruijter Jan M., Jongejan Aldo, Koster Jan, Swagemakers Sigrid M. A., Sokolovic Aleksandar, Lamers Wouter H. Maternal diabetes causes developmental delay and death in early-somite mouse embryos Scientific reports 2017;7 (1):11714 [PubMed]
  • van Groningen Tim, Koster Jan, Valentijn Linda J., Zwijnenburg Danny A., Akogul Nurdan, Hasselt Nancy E., Broekmans Marloes, Haneveld Franciska, Nowakowska Natalia E., Bras Johannes, van Noesel Carel J. M., Jongejan Aldo, van Kampen Antoine H., Koster Linda, Baas Frank, van Dijk-Kerkhoven Lianne, Huizer-Smit Margriet, Lecca Maria C., Chan Alvin, Lakeman Arjan, Molenaar Piet, Volckmann Richard, Westerhout Ellen M., Hamdi Mohamed, van Sluis Peter G., Ebus Marli E., Molenaar Jan J., Tytgat Godelieve A., Westerman Bart A., van Nes Johan, Versteeg Rogier Neuroblastoma is composed of two super-enhancer-associated differentiation states Nature genetics 2017;49 (8):1261-1266 [PubMed]
  • Northcott Paul A., Buchhalter Ivo, Morrissy A. Sorana, Hovestadt Volker, Weischenfeldt Joachim, Ehrenberger Tobias, Gröbner Susanne, Segura-Wang Maia, Zichner Thomas, Rudneva Vasilisa A., Warnatz Hans-Jörg, Sidiropoulos Nikos, Phillips Aaron H., Schumacher Steven, Kleinheinz Kortine, Waszak Sebastian M., Erkek Serap, Jones David T. W., Worst Barbara C., Kool Marcel, Zapatka Marc, Jäger Natalie, Chavez Lukas, Hutter Barbara, Bieg Matthias, Paramasivam Nagarajan, Heinold Michael, Gu Zuguang, Ishaque Naveed, Jäger-Schmidt Christina, Imbusch Charles D., Jugold Alke, Hübschmann Daniel, Risch Thomas, Amstislavskiy Vyacheslav, Gonzalez Francisco German Rodriguez, Weber Ursula D., Wolf Stephan, Robinson Giles W., Zhou Xin, Wu Gang, Finkelstein David, Liu Yanling, Cavalli Florence M. G., Luu Betty, Ramaswamy Vijay, Wu Xiaochong, Koster Jan, Ryzhova Marina, Cho Yoon-Jae, Pomeroy Scott L., Herold-Mende Christel, Schuhmann Martin, Ebinger Martin, Liau Linda M., Mora Jaume, McLendon Roger E., Jabado Nada, Kumabe Toshihiro, Chuah Eric, Ma Yussanne, Moore Richard A., Mungall Andrew J., Mungall Karen L., Thiessen Nina, Tse Kane, Wong Tina, Jones Steven J. M., Witt Olaf, Milde Till, von Deimling Andreas, Capper David, Korshunov Andrey, Yaspo Marie-Laure, Kriwacki Richard, Gajjar Amar, Zhang Jinghui, Beroukhim Rameen, Fraenkel Ernest, Korbel Jan O., Brors Benedikt, Schlesner Matthias, Eils Roland, Marra Marco A., Pfister Stefan M., Taylor Michael D., Lichter Peter The whole-genome landscape of medulloblastoma subtypes Nature 2017;547 (7663):311-317 [PubMed]

2016

  • Savci-Heijink C. Dilara, Halfwerk Hans, Koster Jan, van de Vijver Marc J. A novel gene expression signature for bone metastasis in breast carcinomas Breast cancer research and treatment 2016;156 (2):249-259 [PubMed]
  • Johann Pascal D., Erkek Serap, Zapatka Marc, Kerl Kornelius, Buchhalter Ivo, Hovestadt Volker, Jones David T. W., Sturm Dominik, Hermann Carl, Segura Wang Maia, Korshunov Andrey, Rhyzova Marina, Gröbner Susanne, Brabetz Sebastian, Chavez Lukas, Bens Susanne, Gröschel Stefan, Kratochwil Fabian, Wittmann Andrea, Sieber Laura, Geörg Christina, Wolf Stefan, Beck Katja, Oyen Florian, Capper David, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, von Deimling Andreas, Milde Till, Witt Olaf, Kulozik Andreas E., Ebinger Martin, Shalaby Tarek, Grotzer Michael, Sumerauer David, Zamecnik Josef, Mora Jaume, Jabado Nada, Taylor Michael D., Huang Annie, Aronica Eleonora, Bertoni Anna, Radlwimmer Bernhard, Pietsch Torsten, Schüller Ulrich, Schneppenheim Reinhard, Northcott Paul A., Korbel Jan O., Siebert Reiner, Frühwald Michael C., Lichter Peter, Eils Roland, Gajjar Amar, Hasselblatt Martin, Pfister Stefan M., Kool Marcel Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes Cancer cell 2016;29 (3):379-393 [PubMed]
  • Vellinga T. T., den Uil S., Rinkes I. H. B., Marvin D., Ponsioen B., Alvarez-Varela A., Fatrai S., Scheele C., Zwijnenburg D. A., Snippert H., Vermeulen L., Medema J. P., Stockmann H. B., Koster J., Fijneman R. J. A., de Rooij J., Kranenburg O. Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion Oncogene 2016;35 (40):5263-5271 [PubMed]
  • Matas-Rico Elisa, van Veen Michiel, Leyton-Puig Daniela, van den Berg Jeroen, Koster Jan, Kedziora Katarzyna M., Molenaar Bas, Weerts Marjolein J. A., de Rink Iris, Medema René H., Giepmans Ben N. G., Perrakis Anastassis, Jalink Kees, Versteeg Rogier, Moolenaar Wouter H. Erratum: Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome Cancer cell 2016;30 (6):986 [PubMed]
  • Matas-Rico Elisa, van Veen Michiel, Leyton-Puig Daniela, van den Berg Jeroen, Koster Jan, Kedziora Katarzyna M., Molenaar Bas, Weerts Marjolein J. A., de Rink Iris, Medema René H., Giepmans Ben N. G., Perrakis Anastassis, Jalink Kees, Versteeg Rogier, Moolenaar Wouter H. Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome Cancer cell 2016;30 (4):548-562 [PubMed]
  • Bate-Eya Laurel T., den Hartog Ilona J. M., van der Ploeg Ida, Schild Linda, Koster Jan, Santo Evan E., Westerhout Ellen M., Versteeg Rogier, Caron Huib N., Molenaar Jan J., Dolman M. Emmy M. High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition Oncotarget 2016;7 (19):27946-27958 [PubMed]
  • Fabian Johannes, Opitz Desirée, Althoff Kristina, Lodrini Marco, Hero Barbara, Volland Ruth, Beckers Anneleen, de Preter Katleen, Decock Anneleen, Patil Nitin, Abba Mohammed, Kopp-Schneider Annette, Astrahantseff Kathy, Wünschel Jasmin, Pfeil Sebastian, Ercu Maria, Künkele Annette, Hu Jamie, Thole Theresa, Schweizer Leonille, Mechtersheimer Gunhild, Carter Daniel, Cheung Belamy B., Popanda Odilia, von Deimling Andreas, Koster Jan, Versteeg Rogier, Schwab Manfred, Marshall Glenn M., Speleman Frank, Erb Ulrike, Zoeller Margot, Allgayer Heike, Simon Thorsten, Fischer Matthias, Kulozik Andreas E., Eggert Angelika, Witt Olaf, Schulte Johannes H., Deubzer Hedwig E. MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma Oncotarget 2016;7 (41):66344-66359 [PubMed]
  • Sturm Dominik, Orr Brent A., Toprak Umut H., Hovestadt Volker, Jones David T. W., Capper David, Sill Martin, Buchhalter Ivo, Northcott Paul A., Leis Irina, Ryzhova Marina, Koelsche Christian, Pfaff Elke, Allen Sariah J., Balasubramanian Gnanaprakash, Worst Barbara C., Pajtler Kristian W., Brabetz Sebastian, Johann Pascal D., Sahm Felix, Reimand Jüri, Mackay Alan, Carvalho Diana M., Remke Marc, Phillips Joanna J., Perry Arie, Cowdrey Cynthia, Drissi Rachid, Fouladi Maryam, Giangaspero Felice, Łastowska Maria, Grajkowska Wiesława, Scheurlen Wolfram, Pietsch Torsten, Hagel Christian, Gojo Johannes, Lötsch Daniela, Berger Walter, Slavc Irene, Haberler Christine, Jouvet Anne, Holm Stefan, Hofer Silvia, Prinz Marco, Keohane Catherine, Fried Iris, Mawrin Christian, Scheie David, Mobley Bret C., Schniederjan Matthew J., Santi Mariarita, Buccoliero Anna M., Dahiya Sonika, Kramm Christof M., von Bueren André O., von Hoff Katja, Rutkowski Stefan, Herold-Mende Christel, Frühwald Michael C., Milde Till, Hasselblatt Martin, Wesseling Pieter, Rößler Jochen, Schüller Ulrich, Ebinger Martin, Schittenhelm Jens, Frank Stephan, Grobholz Rainer, Vajtai Istvan, Hans Volkmar, Schneppenheim Reinhard, Zitterbart Karel, Collins V. Peter, Aronica Eleonora, Varlet Pascale, Puget Stephanie, Dufour Christelle, Grill Jacques, Figarella-Branger Dominique, Wolter Marietta, Schuhmann Martin U., Shalaby Tarek, Grotzer Michael, van Meter Timothy, Monoranu Camelia-Maria, Felsberg Jörg, Reifenberger Guido, Snuderl Matija, Forrester Lynn Ann, Koster Jan, Versteeg Rogier, Volckmann Richard, van Sluis Peter, Wolf Stephan, Mikkelsen Tom, Gajjar Amar, Aldape Kenneth, Moore Andrew S., Taylor Michael D., Jones Chris, Jabado Nada, Karajannis Matthias A., Eils Roland, Schlesner Matthias, Lichter Peter, von Deimling Andreas, Pfister Stefan M., Ellison David W., Korshunov Andrey, Kool Marcel New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs Cell 2016;164 (5):1060-1072 [PubMed]
  • Eberhardt Allison, Hansen Jeanne N., Koster Jan, Lotta Louis T., Wang Simeng, Livingstone Emmett, Qian Kun, Valentijn Linda J., Zheng Yujun George, Schor Nina F., Li Xingguo Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma Oncotarget 2016;7 (39):63629-63639 [PubMed]
  • Murakami-Tonami Yuko, Ikeda Haruna, Yamagishi Ryota, Inayoshi Mao, Inagaki Shiho, Kishida Satoshi, Komata Yosuke, Koster Jan, Takeuchi Ichiro, Kondo Yutaka, Maeda Tohru, Sekido Yoshitaka, Murakami Hiroshi, Kadomatsu Kenji SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells Scientific reports 2016;6:31615 [PubMed]
  • Vella Serena, Tavanti Elisa, Hattinger Claudia Maria, Fanelli Marilù, Versteeg Rogier, Koster Jan, Picci Piero, Serra Massimo Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells PLoS ONE 2016;11 (11):e0166233 [PubMed]
  • Middelbeek Jeroen, Vrenken Kirsten, Visser Daan, Lasonder Edwin, Koster Jan, Jalink Kees, Clark Kristopher, van Leeuwen Frank N. The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression European journal of cell biology 2016;95 (11):465-474 [PubMed]

2015

  • Mandriota Stefano J., Valentijn Linda J., Lesne Laurence, Betts David R., Marino Denis, Boudal-Khoshbeen Mary, London Wendy B., Rougemont Anne-Laure, Attiyeh Edward F., Maris John M., Hogarty Michael D., Koster Jan, Molenaar Jan J., Versteeg Rogier, Ansari Marc, Gumy-Pause Fabienne Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism Oncotarget 2015;6 (21):18558-18576 [PubMed]
  • Dolman M. Emmy M., van der Ploeg Ida, Koster Jan, Bate-Eya Laurel Tabe, Versteeg Rogier, Caron Huib N., Molenaar Jan J. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells PLoS ONE 2015;10 (12):e0145744 [PubMed]
  • Yco Lisette P., Geerts Dirk, Mocz Gabor, Koster Jan, Bachmann André S. Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target BMC cancer 2015;15 (1):477 [PubMed]
  • von Stedingk Kristoffer, de Preter Katleen, Vandesompele Jo, Noguera Rosa, Øra Ingrid, Koster Jan, Versteeg Rogier, Påhlman Sven, Lindgren David, Axelson Håkan Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use International journal of cancer. Journal international du cancer 2015;137 (4):868-877 [PubMed]
  • Fatrai Szabolcs, van Schelven Susanne J., Ubink Inge, Govaert Klaas M., Raats Danielle, Koster Jan, Verheem Andre, Borel Rinkes Inne H. M., Kranenburg Onno Maintenance of Clonogenic KIT(+) Human Colon Tumor Cells Requires Secretion of Stem Cell Factor by Differentiated Tumor Cells Gastroenterology 2015;149 (3):692-704 [PubMed]
  • Pajtler Kristian W., Witt Hendrik, Sill Martin, Jones David T. W., Hovestadt Volker, Kratochwil Fabian, Wani Khalida, Tatevossian Ruth, Punchihewa Chandanamali, Johann Pascal, Reimand Jüri, Warnatz Hans-Jörg, Ryzhova Marina, Mack Steve, Ramaswamy Vijay, Capper David, Schweizer Leonille, Sieber Laura, Wittmann Andrea, Huang Zhiqin, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Fults Daniel, Toledano Helen, Avigad Smadar, Hoffman Lindsey M., Donson Andrew M., Foreman Nicholas, Hewer Ekkehard, Zitterbart Karel, Gilbert Mark, Armstrong Terri S., Gupta Nalin, Allen Jeffrey C., Karajannis Matthias A., Zagzag David, Hasselblatt Martin, Kulozik Andreas E., Witt Olaf, Collins V. Peter, von Hoff Katja, Rutkowski Stefan, Pietsch Torsten, Bader Gary, Yaspo Marie-Laure, von Deimling Andreas, Lichter Peter, Taylor Michael D., Gilbertson Richard, Ellison David W., Aldape Kenneth, Korshunov Andrey, Kool Marcel, Pfister Stefan M. Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups Cancer cell 2015;27 (5):728-743 [PubMed]
  • Wegert Jenny, Ishaque Naveed, Vardapour Romina, Geörg Christina, Gu Zuguang, Bieg Matthias, Ziegler Barbara, Bausenwein Sabrina, Nourkami Nasenien, Ludwig Nicole, Keller Andreas, Grimm Clemens, Kneitz Susanne, Williams Richard D., Chagtai Tas, Pritchard-Jones Kathy, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Acha Tomas, O'Sullivan Maureen J., Bode Peter K., Niggli Felix, Tytgat Godelieve A., van Tinteren Harm, van den Heuvel-Eibrink Marry M., Meese Eckart, Vokuhl Christian, Leuschner Ivo, Graf Norbert, Eils Roland, Pfister Stefan M., Kool Marcel, Gessler Manfred Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors Cancer cell 2015;27 (2):298-311 [PubMed]
  • van de Wetering Marc, Francies Hayley E., Francis Joshua M., Bounova Gergana, Iorio Francesco, Pronk Apollo, van Houdt Winan, van Gorp Joost, Taylor-Weiner Amaro, Kester Lennart, McLaren-Douglas Anne, Blokker Joyce, Jaksani Sridevi, Bartfeld Sina, Volckman Richard, van Sluis Peter, Li Vivian S. W., Seepo Sara, Sekhar Pedamallu Chandra, Cibulskis Kristian, Carter Scott L., McKenna Aaron, Lawrence Michael S., Lichtenstein Lee, Stewart Chip, Koster Jan, Versteeg Rogier, van Oudenaarden Alexander, Saez-Rodriguez Julio, Vries Robert G. J., Getz Gad, Wessels Lodewyk, Stratton Michael R., McDermott Ultan, Meyerson Matthew, Garnett Mathew J., Clevers Hans Prospective derivation of a living organoid biobank of colorectal cancer patients Cell 2015;161 (4):933-945 [PubMed]
  • Eleveld Thomas F., Oldridge Derek A., Bernard Virginie, Koster Jan, Daage Leo Colmet, Diskin Sharon J., Schild Linda, Bentahar Nadia Bessoltane, Bellini Angela, Chicard Mathieu, Lapouble Eve, Combaret Valérie, Legoix-Né Patricia, Michon Jean, Pugh Trevor J., Hart Lori S., Rader JulieAnn, Attiyeh Edward F., Wei Jun S., Zhang Shile, Naranjo Arlene, Gastier-Foster Julie M., Hogarty Michael D., Asgharzadeh Shahab, Smith Malcolm A., Guidry Auvil Jaime M., Watkins Thomas B. K., Zwijnenburg Danny A., Ebus Marli E., van Sluis Peter, Hakkert Anne, van Wezel Esther, van der Schoot C. Ellen, Westerhout Ellen M., Schulte Johannes H., Tytgat Godelieve A., Dolman M. Emmy M., Janoueix-Lerosey Isabelle, Gerhard Daniela S., Caron Huib N., Delattre Olivier, Khan Javed, Versteeg Rogier, Schleiermacher Gudrun, Molenaar Jan J., Maris John M. Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations Nature genetics 2015;47 (8):864-871 [PubMed]
  • Best Myron G., Sol Nik, Kooi Irsan, Tannous Jihane, Westerman Bart A., Rustenburg François, Schellen Pepijn, Verschueren Heleen, Post Edward, Koster Jan, Ylstra Bauke, Ameziane Najim, Dorsman Josephine, Smit Egbert F., Verheul Henk M., Noske David P., Reijneveld Jaap C., Nilsson R. Jonas A., Tannous Bakhos A., Wesseling Pieter, Wurdinger Thomas RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics Cancer cell 2015;28 (5):666-676 [PubMed]
  • Vellinga Thomas T., Borovski Tijana, de Boer Vincent C. J., Fatrai Szabolcs, van Schelven Susanne, Trumpi Kari, Verheem Andre, Snoeren Nikol, Emmink Benjamin L., Koster Jan, Rinkes Inne H. M. Borel, Kranenburg Onno SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer Clinical cancer research 2015;21 (12):2870-2879 [PubMed]
  • Valentijn Linda J., Koster Jan, Zwijnenburg Danny A., Hasselt Nancy E., van Sluis Peter, Volckmann Richard, van Noesel Max M., George Rani E., Tytgat Godelieve A. M., Molenaar Jan J., Versteeg Rogier TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors Nature genetics 2015;47 (12):1411-+ [PubMed]
  • Yang Jun, AlTahan Alaa M., Hu Dongli, Wang Yingdi, Cheng Pei-Hsin, Morton Christopher L., Qu Chunxu, Nathwani Amit C., Shohet Jason M., Fotsis Theodore, Koster Jan, Versteeg Rogier, Okada Hitoshi, Harris Adrian L., Davidoff Andrew M. The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma Journal of the National Cancer Institute 2015;107 (6):djv080 [PubMed]
  • van Wezel Esther M., Zwijnenburg Danny, Zappeij-Kannegieter Lily, Bus Erik, van Noesel Max M., Molenaar Jan J., Versteeg Rogier, Fiocco Marta, Caron Huib N., van der Schoot C. Ellen, Koster Jan, Tytgat Godelieve A. M. Whole-genome sequencing identifies patient-specific DNA minimal residual disease markers in neuroblastoma Journal of molecular diagnostics 2015;17 (1):43-52 [PubMed]

2014

  • Hovestadt Volker, Jones David T. W., Picelli Simone, Wang Wei, Kool Marcel, Northcott Paul A., Sultan Marc, Stachurski Katharina, Ryzhova Marina, Warnatz Hans-Jörg, Ralser Meryem, Brun Sonja, Bunt Jens, Jäger Natalie, Kleinheinz Kortine, Erkek Serap, Weber Ursula D., Bartholomae Cynthia C., von Kalle Christof, Lawerenz Chris, Eils Jürgen, Koster Jan, Versteeg Rogier, Milde Till, Witt Olaf, Schmidt Sabine, Wolf Stephan, Pietsch Torsten, Rutkowski Stefan, Scheurlen Wolfram, Taylor Michael D., Brors Benedikt, Felsberg Jörg, Reifenberger Guido, Borkhardt Arndt, Lehrach Hans, Wechsler-Reya Robert J., Eils Roland, Yaspo Marie-Laure, Landgraf Pablo, Korshunov Andrey, Zapatka Marc, Radlwimmer Bernhard, Pfister Stefan M., Lichter Peter Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing Nature 2014;510 (7506):537-541 [PubMed]
  • Bandino Andrea, Geerts Dirk, Koster Jan, Bachmann André S. Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients Cellular oncology 2014;37 (6):387-398 [PubMed]
  • Bryan Kenneth, Terrile Marta, Bray Isabella M., Domingo-Fernandéz Raquel, Watters Karen M., Koster Jan, Versteeg Rogier, Stallings Raymond L. Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis Nucleic acids research 2014;42 (3):e17 [PubMed]
  • Northcott Paul A., Lee Catherine, Zichner Thomas, Stütz Adrian M., Erkek Serap, Kawauchi Daisuke, Shih David J. H., Hovestadt Volker, Zapatka Marc, Sturm Dominik, Jones David T. W., Kool Marcel, Remke Marc, Cavalli Florence M. G., Zuyderduyn Scott, Bader Gary D., VandenBerg Scott, Esparza Lourdes Adriana, Ryzhova Marina, Wang Wei, Wittmann Andrea, Stark Sebastian, Sieber Laura, Seker-Cin Huriye, Linke Linda, Kratochwil Fabian, Jäger Natalie, Buchhalter Ivo, Imbusch Charles D., Zipprich Gideon, Raeder Benjamin, Schmidt Sabine, Diessl Nicolle, Wolf Stephan, Wiemann Stefan, Brors Benedikt, Lawerenz Chris, Eils Jürgen, Warnatz Hans-Jörg, Risch Thomas, Yaspo Marie-Laure, Weber Ursula D., Bartholomae Cynthia C., von Kalle Christof, Turányi Eszter, Hauser Peter, Sanden Emma, Darabi Anna, Siesjö Peter, Sterba Jaroslav, Zitterbart Karel, Sumerauer David, van Sluis Peter, Versteeg Rogier, Volckmann Richard, Koster Jan, Schuhmann Martin U., Ebinger Martin, Grimes H. Leighton, Robinson Giles W., Gajjar Amar, Mynarek Martin, von Hoff Katja, Rutkowski Stefan, Pietsch Torsten, Scheurlen Wolfram, Felsberg Jörg, Reifenberger Guido, Kulozik Andreas E., von Deimling Andreas, Witt Olaf, Eils Roland, Gilbertson Richard J., Korshunov Andrey, Taylor Michael D., Lichter Peter, Korbel Jan O., Wechsler-Reya Robert J., Pfister Stefan M. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma Nature 2014;511 (7510):428-434 [PubMed]
  • Mack S. C., Witt H., Piro R. M., Gu L., Zuyderduyn S., Stütz A. M., Wang X., Gallo M., Garzia L., Zayne K., Zhang X., Ramaswamy V., Jäger N., Jones D. T. W., Sill M., Pugh T. J., Ryzhova M., Wani K. M., Shih D. J. H., Head R., Remke M., Bailey S. D., Zichner T., Faria C. C., Barszczyk M., Stark S., Seker-Cin H., Hutter S., Johann P., Bender S., Hovestadt V., Tzaridis T., Dubuc A. M., Northcott P. A., Peacock J., Bertrand K. C., Agnihotri S., Cavalli F. M. G., Clarke I., Nethery-Brokx K., Creasy C. L., Verma S. K., Koster J., Wu X., Yao Y., Milde T., Sin-Chan P., Zuccaro J., Lau L., Pereira S., Castelo-Branco P., Hirst M., Marra M. A., Roberts S. S., Fults D., Massimi L., Cho Y. J., van Meter T., Grajkowska W., Lach B., Kulozik A. E., von Deimling A., Witt O., Scherer S. W., Fan X., Muraszko K. M., Kool M., Pomeroy S. L., Gupta N., Phillips J., Huang A., Tabori U., Hawkins C., Malkin D., Kongkham P. N., Weiss W. A., Jabado N., Rutka J. T., Bouffet E., Korbel J. O., Lupien M., Aldape K. D., Bader G. D., Eils R., Lichter P., Dirks P. B., Pfister S. M., Korshunov A., Taylor M. D. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy Nature 2014;506 (7489):445-+ [PubMed]
  • van Keimpema Martine, Grüneberg Leonie J., Mokry Michal, van Boxtel Ruben, Koster Jan, Coffer Paul J., Pals Steven T., Spaargaren Marcel FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells Blood 2014;124 (23):3431-3440 [PubMed]
  • Kool Marcel, Jones David T. W., Jäger Natalie, Northcott Paul A., Pugh Trevor J., Hovestadt Volker, Piro Rosario M., Esparza L. Adriana, Markant Shirley L., Remke Marc, Milde Till, Bourdeaut Franck, Ryzhova Marina, Sturm Dominik, Pfaff Elke, Stark Sebastian, Hutter Sonja, Seker-Cin Huriye, Johann Pascal, Bender Sebastian, Schmidt Christin, Rausch Tobias, Shih David, Reimand Jüri, Sieber Laura, Wittmann Andrea, Linke Linda, Witt Hendrik, Weber Ursula D., Zapatka Marc, König Rainer, Beroukhim Rameen, Bergthold Guillaume, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Schmidt Sabine, Wolf Stephan, Lawerenz Chris, Bartholomae Cynthia C., von Kalle Christof, Unterberg Andreas, Herold-Mende Christel, Hofer Silvia, Kulozik Andreas E., von Deimling Andreas, Scheurlen Wolfram, Felsberg Jörg, Reifenberger Guido, Hasselblatt Martin, Crawford John R., Grant Gerald A., Jabado Nada, Perry Arie, Cowdrey Cynthia, Croul Sydney, Zadeh Gelareh, Korbel Jan O., Doz Francois, Delattre Olivier, Bader Gary D., McCabe Martin G., Collins V. Peter, Kieran Mark W., Cho Yoon-Jae, Pomeroy Scott L., Witt Olaf, Brors Benedikt, Taylor Michael D., Schüller Ulrich, Korshunov Andrey, Eils Roland, Wechsler-Reya Robert J., Lichter Peter, Pfister Stefan M. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition Cancer cell 2014;25 (3):393-405 [PubMed]
  • Emmink Benjamin L., Laoukili Jamila, Kipp Anna P., Koster Jan, Govaert Klaas M., Fatrai Szabolcs, Verheem Andre, Steller Ernst J. A., Brigelius-Flohé Regina, Jimenez Connie R., Borel Rinkes Inne H. M., Kranenburg Onno GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer Cancer research 2014;74 (22):6717-6730 [PubMed]
  • Bate-Eya Laurel T., Ebus Marli E., Koster Jan, den Hartog Ilona J. M., Zwijnenburg Danny A., Schild Linda, van der Ploeg Ida, Dolman M. Emmy M., Caron Huib N., Versteeg Rogier, Molenaar Jan J. Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours European journal of cancer (Oxford, England 2014;50 (3):628-637 [PubMed]
  • Lange Ingo, Geerts Dirk, Feith David J., Mocz Gabor, Koster Jan, Bachmann André S. Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation Journal of molecular biology 2014;426 (2):332-346 [PubMed]
  • Kloosterman Wigard P., Koster Jan, Molenaar Jan J. Prevalence and clinical implications of chromothripsis in cancer genomes Current opinion in oncology 2014;26 (1):64-72 [PubMed]
  • Lee Sangkyun, Rahnenführer Jörg, Lang Michel, de Preter Katleen, Mestdagh Pieter, Koster Jan, Versteeg Rogier, Stallings Raymond L., Varesio Luigi, Asgharzadeh Shahab, Schulte Johannes H., Fielitz Kathrin, Schwermer Melanie, Morik Katharina, Schramm Alexander Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling PLoS ONE 2014;9 (10):e108818 [PubMed]

2013

  • van Nes Johan, Chan Alvin, van Groningen Tim, van Sluis Peter, Koster Jan, Versteeg Rogier A NOTCH3 transcriptional module induces cell motility in neuroblastoma Clinical cancer research 2013;19 (13):3485-3494 [PubMed]
  • Zeilstra Jurrit, Joosten Sander P. J., Vermeulen Louis, Koster Jan, Medema Jan Paul, Versteeg Rogier, Spaargaren Marcel, Pals Steven T. CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status PLoS ONE 2013;8 (8):e72849 [PubMed]
  • Koomoa Dana-Lynn T., Geerts Dirk, Lange Ingo, Koster Jan, Pegg Anthony E., Feith David J., Bachmann André S. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma International journal of oncology 2013;42 (4):1219-1228 [PubMed]
  • Stange Daniel E., Koo Bon-Kyoung, Huch Meritxell, Sibbel Greg, Basak Onur, Lyubimova Anna, Kujala Pekka, Bartfeld Sina, Koster Jan, Geahlen Jessica H., Peters Peter J., van Es Johan H., van de Wetering Marc, Mills Jason C., Clevers Hans Differentiated troy(+) chief cells act as reserve stem cells to generate all lineages of the stomach epithelium Cell 2013;155 (2):357-368 [PubMed]
  • Santo Evan E., Stroeken Peter, Sluis Peter V., Koster Jan, Versteeg Rogier, Westerhout Ellen M. FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma Cancer research 2013;73 (7):2189-2198 [PubMed]
  • Jäger Natalie, Schlesner Matthias, Jones David T. W., Raffel Simon, Mallm Jan-Philipp, Junge Kristin M., Weichenhan Dieter, Bauer Tobias, Ishaque Naveed, Kool Marcel, Northcott Paul A., Korshunov Andrey, Drews Ruben M., Koster Jan, Versteeg Rogier, Richter Julia, Hummel Michael, Mack Stephen C., Taylor Michael D., Witt Hendrik, Swartman Benedict, Schulte-Bockholt Dietrich, Sultan Marc, Yaspo Marie-Laure, Lehrach Hans, Hutter Barbara, Brors Benedikt, Wolf Stephan, Plass Christoph, Siebert Reiner, Trumpp Andreas, Rippe Karsten, Lehmann Irina, Lichter Peter, Pfister Stefan M., Eils Roland Hypermutation of the inactive X chromosome is a frequent event in cancer Cell 2013;155 (3):567-581 [PubMed]
  • Das S., Bryan K., Buckley P. G., Piskareva O., Bray I. M., Foley N., Ryan J., Lynch J., Creevey L., Fay J., Prenter S., Koster J., van Sluis P., Versteeg R., Eggert A., Schulte J. H., Schramm A., Mestdagh P., Vandesompele J., Speleman F., Stallings R. L. Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs Oncogene 2013;32 (24):2927-2936 [PubMed]
  • Bunt Jens, Hasselt Nancy A., Zwijnenburg Danny A., Koster Jan, Versteeg Rogier, Kool Marcel OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels Acta neuropathologica 2013;125 (3):385-394 [PubMed]
  • Steller Ernst J. A., Raats Danielle A., Koster Jan, Rutten Bert, Govaert Klaas M., Emmink Benjamin L., Snoeren Nikol, van Hooff Sander R., Holstege Frank C. P., Maas Coen, Borel Rinkes Inne H. M., Kranenburg Onno PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells Neoplasia (New York, N.Y.) 2013;15 (2):204-217 [PubMed]
  • Yco Lisette P., Geerts Dirk, Koster Jan, Bachmann André S. PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma International journal of oncology 2013;42 (4):1408-1416 [PubMed]
  • Jones David T. W., Hutter Barbara, Jäger Natalie, Korshunov Andrey, Kool Marcel, Warnatz Hans-Jörg, Zichner Thomas, Lambert Sally R., Ryzhova Marina, Quang Dong Anh Khuong, Fontebasso Adam M., Stütz Adrian M., Hutter Sonja, Zuckermann Marc, Sturm Dominik, Gronych Jan, Lasitschka Bärbel, Schmidt Sabine, Seker-Cin Huriye, Witt Hendrik, Sultan Marc, Ralser Meryem, Northcott Paul A., Hovestadt Volker, Bender Sebastian, Pfaff Elke, Stark Sebastian, Faury Damien, Schwartzentruber Jeremy, Majewski Jacek, Weber Ursula D., Zapatka Marc, Raeder Benjamin, Schlesner Matthias, Worth Catherine L., Bartholomae Cynthia C., von Kalle Christof, Imbusch Charles D., Radomski Sylwester, Lawerenz Chris, van Sluis Peter, Koster Jan, Volckmann Richard, Versteeg Rogier, Lehrach Hans, Monoranu Camelia, Winkler Beate, Unterberg Andreas, Herold-Mende Christel, Milde Till Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma Nature genetics 2013;45 (8):927-932 [PubMed]
  • von Stedingk Kristoffer, Koster Jan, Piqueras Marta, Noguera Rosa, Navarro Samuel, Påhlman Sven, Versteeg Rogier, Ora Ingrid, Gisselsson David, Lindgren David, Axelson Håkan snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis Translational oncology 2013;6 (4):447-U142 [PubMed]
  • Molenaar J. J., Koster J., Ebus M., Zwijnenburg D. A., van Sluis P., Lamers F., Schild L., van der Ploeg I., Caron H. N., Versteeg R. Targeted Drug Development in Pediatric Cancer Despite a Low Frequency of Tumor Driving Mutations Annals of oncology 2013;24:i7

2012

  • Wu Xiaochong, Northcott Paul A., Dubuc Adrian, Dupuy Adam J., Shih David J. H., Witt Hendrik, Croul Sidney, Bouffet Eric, Fults Daniel W., Eberhart Charles G., Garzia Livia, van Meter Timothy, Zagzag David, Jabado Nada, Schwartzentruber Jeremy, Majewski Jacek, Scheetz Todd E., Pfister Stefan M., Korshunov Andrey, Li Xiao-Nan, Scherer Stephen W., Cho Yoon-Jae, Akagi Keiko, MacDonald Tobey J., Koster Jan, McCabe Martin G., Sarver Aaron L., Collins V. Peter, Weiss William A., Largaespada David A., Collier Lara S., Taylor Michael D. Clonal selection drives genetic divergence of metastatic medulloblastoma Nature 2012;482 (7386):529-U254 [PubMed]
  • Molenaar Jan J., Koster Jan, Ebus Marli E., van Sluis Peter, Westerhout Ellen M., de Preter Katleen, Gisselsson David, Øra Ingrid, Speleman Frank, Caron Huib N., Versteeg Rogier Copy Number Defects of G1-Cell Cycle Genes in Neuroblastoma are Frequent and Correlate with High Expression of E2F Target Genes and a Poor Prognosis Genes, chromosomes & cancer 2012;51 (1):10-19 [PubMed]
  • Jones David T. W., Jäger Natalie, Kool Marcel, Zichner Thomas, Hutter Barbara, Sultan Marc, Cho Yoon-Jae, Pugh Trevor J., Hovestadt Volker, Stütz Adrian M., Rausch Tobias, Warnatz Hans-Jörg, Ryzhova Marina, Bender Sebastian, Sturm Dominik, Pleier Sabrina, Cin Huriye, Pfaff Elke, Sieber Laura, Wittmann Andrea, Remke Marc, Witt Hendrik, Hutter Sonja, Tzaridis Theophilos, Weischenfeldt Joachim, Raeder Benjamin, Avci Meryem, Amstislavskiy Vyacheslav, Zapatka Marc, Weber Ursula D., Wang Qi, Lasitschka Bärbel, Bartholomae Cynthia C., Schmidt Manfred, von Kalle Christof, Ast Volker, Lawerenz Chris, Eils Jürgen, Kabbe Rolf, Benes Vladimir, van Sluis Peter, Koster Jan, Volckmann Richard, Shih David, Betts Matthew J., Russell Robert B., Coco Simona, Tonini Gian Paolo, Schüller Ulrich, Hans Volkmar, Graf Norbert, Kim Yoo-Jin, Monoranu Camelia, Roggendorf Wolfgang, Unterberg Andreas, Herold-Mende Christel, Milde Till, Kulozik Andreas E., von Deimling Andreas, Witt Olaf, Maass Eberhard, Rössler Jochen, Ebinger Martin, Schuhmann Martin U., Frühwald Michael C., Hasselblatt Martin, Jabado Nada, Rutkowski Stefan, von Bueren André O., Williamson Dan, Clifford Steven C., McCabe Martin G., Collins V. Peter, Wolf Stephan, Wiemann Stefan, Lehrach Hans, Brors Benedikt, Scheurlen Wolfram, Felsberg Jörg, Reifenberger Guido, Northcott Paul A., Taylor Michael D., Meyerson Matthew, Pomeroy Scott L., Yaspo Marie-Laure, Korbel Jan O., Korshunov Andrey, Eils Roland, Pfister Stefan M., Lichter Peter Dissecting the genomic complexity underlying medulloblastoma Nature 2012;488 (7409):100-105 [PubMed]
  • Schramm A., Schowe B., Fielitz K., Heilmann M., Martin M., Marschall T., Köster J., Vandesompele J., Vermeulen J., de Preter K., Koster J., Versteeg R., Noguera R., Speleman F., Rahmann S., Eggert A., Morik K., Schulte J. H. Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome British journal of cancer 2012;107 (8):1409-1417 [PubMed]
  • Valentijn Linda J., Koster Jan, Haneveld Franciska, Aissa Rachida Ait, van Sluis Peter, Broekmans Marloes E. C., Molenaar Jan J., van Nes Johan, Versteeg Rogier Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification Proceedings of the National Academy of Sciences of the United States of America 2012;109 (47):19190-19195 [PubMed]
  • Rausch Tobias, Jones David T. W., Zapatka Marc, Stütz Adrian M., Zichner Thomas, Weischenfeldt Joachim, Jäger Natalie, Remke Marc, Shih David, Northcott Paul A., Pfaff Elke, Tica Jelena, Wang Qi, Massimi Luca, Witt Hendrik, Bender Sebastian, Pleier Sabrina, Cin Huriye, Hawkins Cynthia, Beck Christian, von Deimling Andreas, Hans Volkmar, Brors Benedikt, Eils Roland, Scheurlen Wolfram, Blake Jonathon, Benes Vladimir, Kulozik Andreas E., Witt Olaf, Martin Dianna, Zhang Cindy, Porat Rinnat, Merino Diana M., Wasserman Jonathan, Jabado Nada, Fontebasso Adam, Bullinger Lars, Rücker Frank G., Döhner Konstanze, Döhner Hartmut, Koster Jan, Molenaar Jan J., Versteeg Rogier, Kool Marcel, Tabori Uri, Malkin David, Korshunov Andrey, Taylor Michael D., Lichter Peter, Pfister Stefan M., Korbel Jan O. Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations Cell 2012;148 (1-2):59-71 [PubMed]
  • Sturm Dominik, Witt Hendrik, Hovestadt Volker, Khuong-Quang Dong-Anh, Jones David T. W., Konermann Carolin, Pfaff Elke, Tönjes Martje, Sill Martin, Bender Sebastian, Kool Marcel, Zapatka Marc, Becker Natalia, Zucknick Manuela, Hielscher Thomas, Liu Xiao-Yang, Fontebasso Adam M., Ryzhova Marina, Albrecht Steffen, Jacob Karine, Wolter Marietta, Ebinger Martin, Schuhmann Martin U., van Meter Timothy, Frühwald Michael C., Hauch Holger, Pekrun Arnulf, Radlwimmer Bernhard, Niehues Tim, von Komorowski Gregor, Dürken Matthias, Kulozik Andreas E., Madden Jenny, Donson Andrew, Foreman Nicholas K., Drissi Rachid, Fouladi Maryam, Scheurlen Wolfram, von Deimling Andreas, Monoranu Camelia, Roggendorf Wolfgang, Herold-Mende Christel, Unterberg Andreas, Kramm Christof M., Felsberg Jörg, Hartmann Christian, Wiestler Benedikt, Wick Wolfgang, Milde Till, Witt Olaf, Lindroth Anders M., Schwartzentruber Jeremy, Faury Damien, Fleming Adam, Zakrzewska Magdalena, Liberski Pawel P., Zakrzewski Krzysztof, Hauser Peter, Garami Miklos, Klekner Almos, Bognar Laszlo, Morrissy Sorana, Cavalli Florence, Taylor Michael D., van Sluis Peter, Koster Jan, Versteeg Rogier, Volckmann Richard, Mikkelsen Tom, Aldape Kenneth, Reifenberger Guido, Collins V. Peter, Majewski Jacek, Korshunov Andrey, Lichter Peter, Plass Christoph, Jabado Nada, Pfister Stefan M. Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma Cancer cell 2012;22 (4):425-437 [PubMed]
  • Lamers Fieke, Schild Linda, Koster Jan, Speleman Frank, Øra Ingrid, Westerhout Ellen M., van Sluis Peter, Versteeg Rogier, Caron Huib N., Molenaar Jan J. Identification of BIRC6 as a novel intervention target for neuroblastoma therapy BMC cancer 2012;12 (1):285 [PubMed]
  • Korshunov Andrey, Ryzhova Marina, Jones David T. W., Northcott Paul A., van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Cowdrey Cynthia, Perry Arie, Picard Daniel, Rosenblum Marc, Giangaspero Felice, Aronica Eleonora, Schüller Ulrich, Hasselblatt Martin, Collins V. Peter, von Deimling Andreas, Lichter Peter, Huang Annie, Pfister Stefan M., Kool Marcel LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR) Acta neuropathologica 2012;124 (6):875-881 [PubMed]
  • Molenaar Jan J., Domingo-Fernández Raquel, Ebus Marli E., Lindner Sven, Koster Jan, Drabek Ksenija, Mestdagh Pieter, van Sluis Peter, Valentijn Linda J., van Nes Johan, Broekmans Marloes, Haneveld Franciska, Volckmann Richard, Bray Isabella, Heukamp Lukas, Sprüssel Annika, Thor Theresa, Kieckbusch Kristina, Klein-Hitpass Ludger, Fischer Matthias, Vandesompele Jo, Schramm Alexander, van Noesel Max M., Varesio Luigi, Speleman Frank, Eggert Angelika, Stallings Raymond L., Caron Huib N., Versteeg Rogier, Schulte Johannes H. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression Nature genetics 2012;44 (11):1199-1206 [PubMed]
  • von Bueren A. O., Bacolod M. D., Hagel C., Heinimann K., Fedier A., Kordes U., Pietsch T., Koster J., Grotzer M. A., Friedman H. S., Marra G., Kool M., Rutkowski S. Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours British journal of cancer 2012;107 (8):1399-1408 [PubMed]
  • Kool Marcel, Korshunov Andrey, Remke Marc, Jones David T. W., Schlanstein Maria, Northcott Paul A., Cho Yoon-Jae, Koster Jan, Schouten-van Meeteren Antoinette, van Vuurden Dannis, Clifford Steven C., Pietsch Torsten, von Bueren Andre O., Rutkowski Stefan, McCabe Martin, Collins V. Peter, Bäcklund Magnus L., Haberler Christine, Bourdeaut Franck, Delattre Olivier, Doz Francois, Ellison David W., Gilbertson Richard J., Pomeroy Scott L., Taylor Michael D., Lichter Peter, Pfister Stefan M. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas Acta neuropathologica 2012;123 (4):473-484 [PubMed]
  • Kemper Kristel, Versloot Miranda, Cameron Katherine, Colak Selçuk, de Sousa E Melo Felipe, de Jong Joan H., Bleackley Joanne, Vermeulen Louis, Versteeg Rogier, Koster Jan, Medema Jan Paul Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer Clinical cancer research 2012;18 (11):3132-3141 [PubMed]
  • Santo E. E., Ebus M. E., Koster J., Schulte J. H., Lakeman A., van Sluis P., Vermeulen J., Gisselsson D., Øra I., Lindner S., Buckley P. G., Stallings R. L., Vandesompele J., Eggert A., Caron H. N., Versteeg R., Molenaar J. J. Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma Oncogene 2012;31 (12):1571-1581 [PubMed]
  • Bunt Jens, Hasselt Nancy E., Zwijnenburg Danny A., Hamdi Mohamed, Koster Jan, Versteeg Rogier, Kool Marcel OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells International journal of cancer. Journal international du cancer 2012;131 (2):E21-E32 [PubMed]
  • Gawecka Joanna E., Geerts Dirk, Koster Jan, Caliva Maisel J., Sulzmaier Florian J., Opoku-Ansah John, Wada Randal K., Bachmann André S., Ramos Joe W. PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma International journal of cancer. Journal international du cancer 2012;131 (7):1556-1568 [PubMed]
  • Molenaar Jan J., Koster Jan, Zwijnenburg Danny A., van Sluis Peter, Valentijn Linda J., van der Ploeg Ida, Hamdi Mohamed, van Nes Johan, Westerman Bart A., van Arkel Jennemiek, Ebus Marli E., Haneveld Franciska, Lakeman Arjan, Schild Linda, Molenaar Piet, Stroeken Peter, van Noesel Max M., Ora Ingrid, Santo Evan E., Caron Huib N., Westerhout Ellen M., Versteeg Rogier Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes Nature 2012;483 (7391):589-U107 [PubMed]
  • Lamers Fieke, Schild Linda, den Hartog Ilona J. M., Ebus Marli E., Westerhout Ellen M., Ora Ingrid, Koster Jan, Versteeg Rogier, Caron Huib N., Molenaar Jan J. Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth European journal of cancer (Oxford, England 2012;48 (16):3093-3103 [PubMed]
  • Lamers Fieke, Schild Linda, Koster Jan, Versteeg Rogier, Caron Huib N., Molenaar Jan J. Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression European journal of cancer (Oxford, England 2012;48 (5):763-771 [PubMed]
  • Muñoz Javier, Stange Daniel E., Schepers Arnout G., van de Wetering Marc, Koo Bon-Kyoung, Itzkovitz Shalev, Volckmann Richard, Kung Kevin S., Koster Jan, Radulescu Sorina, Myant Kevin, Versteeg Rogier, Sansom Owen J., van Es Johan H., Barker Nick, van Oudenaarden Alexander, Mohammed Shabaz, Heck Albert J. R., Clevers Hans The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers EMBO journal 2012;31 (14):3079-3091 [PubMed]

2011

  • Murphy Derek M., Buckley Patrick G., Bryan Kenneth, Watters Karen M., Koster Jan, van Sluis Peter, Molenaar Jan, Versteeg Rogier, Stallings Raymond L. Dissection of the Oncogenic MYCN Transcriptional Network Reveals a Large Set of Clinically Relevant Cell Cycle Genes as Drivers of Neuroblastoma Tumorigenesis Molecular carcinogenesis 2011;50 (6):403-411 [PubMed]
  • Buckley Patrick G., Das Sudipto, Bryan Kenneth, Watters Karen M., Alcock Leah, Koster Jan, Versteeg Rogier, Stallings Raymond L. Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions International journal of cancer. Journal international du cancer 2011;128 (10):2296-2305 [PubMed]
  • Bunt Jens, Hasselt Nancy E., Zwijnenburg Danny A., Koster Jan, Versteeg Rogier, Kool Marcel Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma PLoS ONE 2011;6 (10):e26058 [PubMed]
  • Lamers Fieke, van der Ploeg Ida, Schild Linda, Ebus Marli E., Koster Jan, Hansen Bo R., Koch Troels, Versteeg Rogier, Caron Huib N., Molenaar Jan J. Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe Endocrine-related cancer 2011;18 (6):657-668 [PubMed]
  • de Sousa E Melo Felipe, Colak Selcuk, Buikhuisen Joyce, Koster Jan, Cameron Kate, de Jong Joan H., Tuynman Jurriaan B., Prasetyanti Pramudita R., Fessler Evelyn, van den Bergh Saskia P., Rodermond Hans, Dekker Evelien, van der Loos Chris M., Pals Steven T., van de Vijver Marc J., Versteeg Rogier, Richel Dick J., Vermeulen Louis, Medema Jan Paul Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients Cell stem cell 2011;9 (5):476-485 [PubMed]

2010

  • Molenaar J. J., Ebus M. E., Koster J., Santo E., Geerts D., Versteeg R., Caron H. N. Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells Oncogene 2010;29 (18):2739-2745 [PubMed]
  • Mokry Michal, Hatzis Pantelis, de Bruijn Ewart, Koster Jan, Versteeg Rogier, Schuijers Jurian, van de Wetering Marc, Guryev Victor, Clevers Hans, Cuppen Edwin Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles PLoS ONE 2010;5 (11):e15092 [PubMed]
  • Revet Ingrid, Huizenga Gerda, Koster Jan, Volckmann Richard, van Sluis Peter, Versteeg Rogier, Geerts Dirk MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3 Cancer letters 2010;289 (2):195-207 [PubMed]
  • Hölzel Michael, Huang Sidong, Koster Jan, Ora Ingrid, Lakeman Arjan, Caron Huib, Nijkamp Wouter, Xie Jing, Callens Tom, Asgharzadeh Shahab, Seeger Robert C., Messiaen Ludwine, Versteeg Rogier, Bernards René NF1 Is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease Outcome Cell 2010;142 (2):218-229 [PubMed]
  • Bunt Jens, de Haas Talitha G., Hasselt Nancy E., Zwijnenburg Danny A., Koster Jan, Versteeg Rogier, Kool Marcel Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines Molecular cancer research 2010;8 (10):1344-1357 [PubMed]
  • Verissimo Carla S., Molenaar Jan J., Meerman John, Puigvert Jordi Carreras, Lamers Fieke, Koster Jan, Danen Erik, van de Water Bob, Versteeg Rogier, Fitzsimons Carlos P., Vreugdenhil Erno Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells Endocrine-related cancer 2010;17 (2):399-414 [PubMed]
  • Borsics Tamás, Lundberg Emma, Geerts Dirk, Koomoa Dana-Lynn T., Koster Jan, Wester Kenneth, Bachmann André S. Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration Cancer science 2010;101 (7):1624-1631 [PubMed]
  • Geerts Dirk, Koster Jan, Albert David, Koomoa Dana-Lynn T., Feith David J., Pegg Anthony E., Volckmann Richard, Caron Huib, Versteeg Rogier, Bachmann André S. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification International journal of cancer. Journal international du cancer 2010;126 (9):2012-2024 [PubMed]

2009

  • Cimmino F., Schulte J. H., Zollo M., Koster J., Versteeg R., Iolascon A., Eggert A., Schramm A. Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness Oncogene 2009;28 (19):2015-2023 [PubMed]
  • Missiaglia Edoardo, Selfe Joanna, Hamdi Mohamed, Williamson Daniel, Schaaf Gerben, Fang Cheng, Koster Jan, Summersgill Brenda, Messahel Boo, Versteeg Rogier, Pritchard-Jones Kathy, Kool Marcel, Shipley Janet Genomic Imbalances in Rhabdomyosarcoma Cell Lines Affect Expression of Genes Frequently Altered in Primary Tumors: An Approach to Identify Candidate Genes Involved in Tumor Development Genes, chromosomes & cancer 2009;48 (6):455-467 [PubMed]
  • Molenaar Jan J., Ebus Marli E., Geerts Dirk, Koster Jan, Lamers Fieke, Valentijn Linda J., Westerhout Ellen M., Versteeg Rogier, Caron Huib N. Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells Proceedings of the National Academy of Sciences of the United States of America 2009;106 (31):12968-12973 [PubMed]
  • Schulte Johannes H., Lim Soyoung, Schramm Alexander, Friedrichs Nicolaus, Koster Jan, Versteeg Rogier, Ora Ingrid, Pajtler Kristian, Klein-Hitpass Ludger, Kuhfittig-Kulle Steffi, Metzger Eric, Schüle Roland, Eggert Angelika, Buettner Reinhard, Kirfel Jutta Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy Cancer research 2009;69 (5):2065-2071 [PubMed]
  • van Hooff Sander R., Koster Jan, Hulsen Tim, van Schaik Barbera D. C., Roos Marco, van Batenburg Marcel F., Versteeg Rogier, van Kampen Antoine H. C. The Construction of Genome-Based Transcriptional Units Omics 2009;13 (2):105-114 [PubMed]
  • Schulte Johannes H., Pentek Falk, Hartmann Wolfgang, Schramm Alexander, Friedrichs Nicolaus, Ora Ingrid, Koster Jan, Versteeg Rogier, Kirfel Jutta, Buettner Reinhard, Eggert Angelika The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo International journal of cancer. Journal international du cancer 2009;124 (10):2488-2494 [PubMed]
  • Huang Sidong, Laoukili Jamila, Epping Mirjam T., Koster Jan, Hölzel Michael, Westerman Bart A., Nijkamp Wouter, Hata Akiko, Asgharzadeh Shahab, Seeger Robert C., Versteeg Rogier, Beijersbergen Roderick L., Bernards René ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome Cancer cell 2009;15 (4):328-340 [PubMed]

2008

  • Molenaar Jan J., Ebus Marli E., Koster Jan, van Sluis Peter, van Noesel Carel J. M., Versteeg Rogier, Caron Huib N. Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma Cancer research 2008;68 (8):2599-2609 [PubMed]
  • Koppen Arjen, Ait-Aissa Rachida, Koster Jan, Øra Ingrid, Bras Johannes, van Sluis Peter G., Caron Huib, Versteeg Rogier, Valentijn Linda J. Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN International journal of cancer. Journal international du cancer 2008;122 (7):1455-1464 [PubMed]
  • Hatzis Pantelis, van der Flier Laurens G., van Driel Marc A., Guryev Victor, Nielsen Fiona, Denissov Sergei, Nijman Isaäc J., Koster Jan, Santo Evan E., Welboren Willem, Versteeg Rogier, Cuppen Edwin, van de Wetering Marc, Clevers Hans, Stunnenberg Hendrik G. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells Molecular and cellular biology 2008;28 (8):2732-2744 [PubMed]
  • Kool Marcel, Koster Jan, Bunt Jens, Hasselt Nancy E., Lakeman Arjan, van Sluis Peter, Troost Dirk, Schouten-van Meeteren Netteke A. Y., Caron Huib N., Cloos Jacqueline, Mrsić Alan, Ylstra Bauke, Grajkowska Wieslawa, Hartmann Wolfgang, Pietsch Torsten, Ellison David, Clifford Steven C., Versteeg Rogier Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features PLoS ONE 2008;3 (8):e3088 [PubMed]
  • Merks Johannes H. M., Ozgen Heval M., Koster Jan, Zwinderman Aeilko H., Caron Huib N., Hennekam Raoul C. M. Prevalence and patterns of morphological abnormalities in patients with childhood cancer JAMA 2008;299 (1):61-69 [PubMed]
  • Revet Ingrid, Huizenga Gerda, Chan Alvin, Koster Jan, Volckmann Richard, van Sluis Peter, Øra Ingrid, Versteeg Rogier, Geerts Dirk The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma Experimental cell research 2008;314 (4):707-719 [PubMed]

2007

  • Koppen Arjen, Ait-Aissa Rachida, Hopman Saskia, Koster Jan, Haneveld Franciska, Versteeg Rogier, Valentijn Linda J. Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation Cancer letters 2007;256 (2):218-228 [PubMed]
  • Koppen Arjen, Ait-Aissa Rachida, Koster Jan, van Sluis Peter G., Ora Ingrid, Caron Huib N., Volckmann Richard, Versteeg Rogier, Valentijn Linda J. Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma European journal of cancer (Oxford, England 2007;43 (16):2413-2422 [PubMed]
  • Gierman Hinco J., Indemans Mireille H. G., Koster Jan, Goetze Sandra, Seppen Jurgen, Geerts Dirk, van Driel Roel, Versteeg Rogier Domain-wide regulation of gene expression in the human genome Genome research 2007;17 (9):1286-1295 [PubMed]
  • Geerts Dirk, Wallick Christopher J., Koomoa Dana-Lynn T., Koster Jan, Versteeg Rogier, Go Ramon Christopher V., Bachmann André S. Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation Clinical cancer research 2007;13 (21):6312-6319 [PubMed]
  • Mainguy Gaëll, Koster Jan, Woltering Joost, Jansen Hans, Durston Antony Extensive polycistronism and antisense transcription in the Mammalian Hox clusters PLoS ONE 2007;2 (4):e356 [PubMed]
  • Goetze Sandra, Mateos-Langerak Julio, Gierman Hinco J., de Leeuw Wim, Giromus Osdilly, Indemans Mireille H. G., Koster Jan, Ondrej Vladan, Versteeg Rogier, van Driel Roel The three-dimensional structure of human interphase chromosomes is related to the transcriptome map Molecular and cellular biology 2007;27 (12):4475-4487 [PubMed]

2006

  • Valentijn Linda J., Koster Jan, Versteeg Rogier Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV Genomics 2006;87 (4):483-489 [PubMed]

2004

  • Waterham H. R., Koster J., Romeijn G. J., Vreken P., Hennekam R. C. M., Andersson H. C., Fitzpatrick D. R., Kelley R. I., Wanders R. J. A. Moleculaire basis van desmosterolosis, een autosomaal recessief overervend defect in de cholesterol Nederlands tijdschrift voor geneeskunde 2004;148 (5):253

2003

  • Koster Jan, Geerts Dirk, Favre Bertrand, Borradori Luca, Sonnenberg Arnoud Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly Journal of cell science 2003;116 (2):387-399 [PubMed]
  • Koster J. J. B. Plakin interactions in the hemidesmosome 2003. 127p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Berns A. J. M.; Co-supervisor: Sonnenberg A.)

2002

  • El Mourabit Haquima, Poinat Patrice, Koster Jan, Sondermann Holger, Wixler Viktor, Wegener Elmar, Laplantine Emmanuel, Geerts Dirk, Georges-Labouesse Elisabeth, Sonnenberg Arnoud, Aumailley Monique The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits Matrix biology 2002;21 (2):207-214 [PubMed]

2001

  • Waterham H. R., Koster J., Romeijn G. J., Hennekam R. C., Vreken P., Andersson H. C., Fitzpatrick D. R., Kelley R. I., Wanders R. J. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis American journal of human genetics 2001;69 (4):685-694 [PubMed]
  • Houten S. M., Koster J., Romeijn G. J., Frenkel J., Di Rocco M., Caruso U., Landrieu P., Kelley R. I., Kuis W., Poll-The B. T., Gibson K. M., Wanders R. J., Waterham H. R. Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome European journal of human genetics 2001;9 (4):253-259 [PubMed]
  • Houten S. M., Koster J., Romeijn G. J., Frenkel J., Di Rocco M., Caruso U., Landrieu P., Kelley R. I., Kuis W., Poll-The B. T., Gibson K. M., Wanders R. J. A., Waterham H. R. Organization of the mevalonate kinase (MVK) gene and identification of novel mutations causing mevalonic aciduria and hyperimmunoglobulinaemia D and periodic fever syndrome (vol 9, pg 253, 2001) European journal of human genetics 2001;9 (8):651
  • Fontao L., Geerts D., Kuikman I., Koster J., Kramer D., Sonnenberg A. The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectin Journal of cell science 2001;114 (Part 11):2065-2076 [PubMed]

1999

  • Houten S. M., Romeijn G. J., Koster J., Gray R. G., Darbyshire P., Smit G. P., de Klerk J. B., Duran M., Gibson K. M., Wanders R. J., Waterham H. R. Identification and characterization of three novel missense mutations in mevalonate kinase cDNA causing mevalonic aciduria, a disorder of isoprene biosynthesis Human molecular genetics 1999;8 (8):1523-1528 [PubMed]

Corona-maatregelen

We zetten ons in om ons ziekenhuis veilig te houden tijdens de coronacrisis.

Lees deze extra maatregelen goed door voordat u een van onze locaties bezoekt: