J.L. Frijling publications

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Publications J.L. Frijling

Position
Other Academic Staff
Main activities
Research
Specialisation
psychotrauma, PTSD, oxytocin, stress, neuroimaging, clinical research
Focus of research

Mainly involved in conducting a clinical and neuroimaging study on the effects of intranasal oxytocin administration in recently traumatized individuals at increased risk of developing post-traumatic stress disorder (PTSD).

The clinical study is a multicenter randomized double-blind placebo-controlled trial in patients who were recently exposed to a traumatic event and were treated at the Emergency Department of one of our participating hospitals. We assess the efficacy of intranasal oxytocin administration to prevent PTSD development in those individuals at increased risk of developing PTSD. The neuroimaging study is a cross-sectional study aimed to study the acute effects of intranasal oxytocin administration (vs. placebo) on traumatic stress reactivity in the brain in this population. In addition, both studies investigate the effects of intranasal oxytocin administration on a variety of neuroendocrine, physiological, and behavioral measures.

 

2020

  • Wang Xin, Xie Hong, Chen Tian, Cotton Andrew S., Salminen Lauren E., Logue Mark W., Clarke-Rubright Emily K., Wall John, Dennis Emily L., O’Leary Brian M., Abdallah Chadi G., Andrew Elpiniki, Baugh Lee A., Bomyea Jessica, Bruce Steven E., Bryant Richard, Choi Kyle, Daniels Judith K., Davenport Nicholas D., Davidson Richard J., DeBellis Michael, deRoon-Cassini Terri, Disner Seth G., Fani Negar, Fercho Kelene A., Fitzgerald Jacklynn, Forster Gina L., Frijling Jessie L., Geuze Elbert, Gomaa Hassaan, Gordon Evan M., Grupe Dan, Harpaz-Rotem Ilan, Haswell Courtney C., Herzog Julia I., Hofmann David, Hollifield Michael, Hosseini Bobak, Hudson Anna R., Ipser Jonathan, Jahanshad Neda, Jovanovic Tanja, Kaufman Milissa L., King Anthony P., Koch Saskia B. J., Koerte Inga K., Korgaonkar Mayuresh S., Krystal John H., Larson Christine, Lebois Lauren A. M., Levy Ifat, Li Gen, Magnotta Vincent A., Manthey Antje, May Geoffrey, McLaughlin Katie A., Mueller Sven C., Nawijn Laura, Nelson Steven M., Neria Yuval, Nitschke Jack B., Olff Miranda, Olson Elizabeth A., Peverill Matthew, Luan Phan K., Rashid Faisal M., Ressler Kerry, Rosso Isabelle M., Sambrook Kelly, Schmahl Christian, Shenton Martha E., Sierk Anika, Simons Jeffrey S., Simons Raluca M., Sponheim Scott R., Stein Murray B., Stein Dan J., Stevens Jennifer S., Straube Thomas, Suarez-Jimenez Benjamin, Tamburrino Marijo, Thomopoulos Sophia I., van der Wee Nic J. A., van der Werff Steven J. A., van Erp Theo G. M., van Rooij Sanne J. H., van Zuiden Mirjam, Varkevisser Tim, Veltman Dick J., Vermeiren Robert R. J. M., Walter Henrik, Wang Li, Zhu Ye, Zhu Xi, Thompson Paul M., Morey Rajendra A., Liberzon Israel Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis Molecular psychiatry 2020 [PubMed]
  • Engel Sinha, van Zuiden Mirjam, Frijling Jessie. L., Koch Saskia B. J., Nawijn Laura, Yildiz Rinde L. W., Schumacher Sarah, Knaevelsrud Christine, Bosch Jos A., Veltman Dick J., Olff Miranda Early posttraumatic autonomic and endocrine markers to predict posttraumatic stress symptoms after a preventive intervention with oxytocin European journal of psychotraumatology 2020;11 (1) [PubMed]

2019

  • Dennis Emily L., Disner Seth G., Fani Negar, Salminen Lauren E., Logue Mark, Clarke Emily K., Haswell Courtney C., Averill Christopher L., Baugh Lee A., Bomyea Jessica, Bruce Steven E., Cha Jiook, Choi Kyle, Davenport Nicholas D., Densmore Maria, du Plessis Stefan, Forster Gina L., Frijling Jessie L., Gonenc Atilla, Gruber Staci, Grupe Daniel W., Guenette Jeffrey P., Hayes Jasmeet, Hofmann David, Ipser Jonathan, Jovanovic Tanja, Kelly Sinead, Kennis Mitzy, Kinzel Philipp, Koch Saskia B. J., Koerte Inga, Koopowitz Sheri, Korgaonkar Mayuresh, Krystal John, Lebois Lauren A. M., Li Gen, Magnotta Vincent A., Manthey Antje, May Geoff J., Menefee Deleene S., Nawijn Laura, Nelson Steven M., Neufeld Richard W. J., Nitschke Jack B., O’Doherty Daniel, Peverill Matthew, Ressler Kerry J., Roos Annerine, Sheridan Margaret A., Sierk Anika, Simmons Alan, Simons Raluca M., Simons Jeffrey S., Stevens Jennifer, Suarez-Jimenez Benjamin, Sullivan Danielle R., Théberge Jean, Tran Jana K., van den Heuvel Leigh, van der Werff Steven J. A., van Rooij Sanne J. H., van Zuiden Mirjam, Velez Carmen, Verfaellie Mieke, Vermeiren Robert R. J. M., Wade Benjamin S. C., Wager Tor, Walter Henrik, Winternitz Sherry, Wolff Jonathan, York Gerald, Zhu Ye, Zhu Xi, Abdallah Chadi G., Bryant Richard, Daniels Judith K., Davidson Richard J., Fercho Kelene A., Franz Carol, Geuze Elbert, Gordon Evan M., Kaufman Milissa L., Kremen William S., Lagopoulos Jim, Lanius Ruth A., Lyons Michael J., McCauley Stephen R., McGlinchey Regina, McLaughlin Katie A., Milberg William, Neria Yuval, Olff Miranda, Seedat Soraya, Shenton Martha, Sponheim Scott R., Stein Dan J., Stein Murray B., Straube Thomas, Tate David F., van der Wee Nic J. A., Veltman Dick J., Wang Li., Wilde Elisabeth A., Thompson Paul M., Kochunov Peter, Jahanshad Neda, Morey Rajendra A. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium Molecular psychiatry 2019 [PubMed]
  • van Zuiden Mirjam, Savas Mesut, Koch Saskia B. J., Nawijn Laura, Staufenbiel Sabine M., Frijling Jessie L., Veltman Dick J., van Rossum Elisabeth F. C., Olff Miranda Associations Among Hair Cortisol Concentrations, Posttraumatic Stress Disorder Status, and Amygdala Reactivity to Negative Affective Stimuli in Female Police Officers Journal of traumatic stress 2019;32 (2):238-248 [PubMed]
  • Koch Saskia B. J., van Zuiden Mirjam, Nawijn Laura, Frijling Jessie L., Veltman Dick J., Olff Miranda Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder European neuropsychopharmacology 2019;29 (2):266-277 [PubMed]
  • Nawijn L., Krzyzewska I. M., van Zuiden M., Henneman P., Koch S. B. J., Mul A. N., Frijling J. L., Veltman D. J., Mannens M. M. A. M., Olff M. Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls European neuropsychopharmacology 2019;29 (1):147-155 [PubMed]
  • Engel Sinha, van Zuiden Mirjam, Frijling Jessie L., Koch Saskia B. J., Nawijn Laura, Schumacher Sarah, Knaevelsrud Christine, Veltman Dick J., Olff Miranda Patterns of Recovery From Early Posttraumatic Stress Symptoms After a Preventive Intervention With Oxytocin: Hormonal Contraception Use Is a Prognostic Factor Biological psychiatry 2019;85 (12):e71-e73 [PubMed]

2018

  • Krzyzewska Izabela M., Ensink Judith B. M., Nawijn Laura, Mul Adri N., Koch Saskia B., Venema Andrea, Shankar Vinod, Frijling Jessie L., Veltman Dirk J., Lindauer Ramon J. L., Olff Miranda, Mannens Marcel M. A. M., van Zuiden Mirjam, Henneman Peter Genetic variant in CACNA1C is associated with PTSD in traumatized police officers European journal of human genetics 2018;26 (2):247-257 [PubMed]
  • Lok Anja, Frijling Jessie L., van Zuiden Mirjam Posttraumatic stress disorder: Current insights in diagnostics, treatment and prevention Nederlands tijdschrift voor geneeskunde 2018;162 (3)
  • Lok A., Frijling J. L., van Zuiden M. Posttraumatische stressstoornis Nederlands tijdschrift voor geneeskunde 2018;161:D1905 [PubMed]
  • Logue Mark W., van Rooij Sanne J. H., Dennis Emily L., Davis Sarah L., Hayes Jasmeet P., Stevens Jennifer S., Densmore Maria, Haswell Courtney C., Ipser Jonathan, Koch Saskia B. J., Korgaonkar Mayuresh, Lebois Lauren A. M., Peverill Matthew, Baker Justin T., Boedhoe Premika S. W., Frijling Jessie L., Gruber Staci A., Harpaz-Rotem Ilan, Jahanshad Neda, Koopowitz Sheri, Levy Ifat, Nawijn Laura, O'Connor Lauren, Olff Miranda, Salat David H., Sheridan Margaret A., Spielberg Jeffrey M., van Zuiden Mirjam, Winternitz Sherry R., Wolff Jonathan D., Wolf Erika J., Wang Xin, Wrocklage Kristen, Abdallah Chadi G., Bryant Richard A., Geuze Elbert, Jovanovic Tanja, Kaufman Milissa L., King Anthony P., Krystal John H., Lagopoulos Jim, Bennett Maxwell, Lanius Ruth, Liberzon Israel, McGlinchey Regina E., McLaughlin Katie A., Milberg William P., Miller Mark W., Ressler Kerry J., Veltman Dick J., Stein Dan J., Thomaes Kathleen, Thompson Paul M., Morey Rajendra A. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia Biological psychiatry 2018;83 (3):244-253 [PubMed]

2017

  • Koch Saskia B. J., van Zuiden Mirjam, Nawijn Laura, Frijling Jessie L., Veltman Dick J., Olff Miranda Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study Journal of psychiatry & neuroscience 2017;42 (5):331-342 [PubMed]
  • Nawijn Laura, van Zuiden Mirjam, Koch Saskia B. J., Frijling Jessie L., Veltman Dick J., Olff Miranda Intranasal oxytocin increases neural responses to social reward in post-traumatic stress disorder Social cognitive and affective neuroscience 2017;12 (2):212-223 [PubMed]
  • van Zuiden Mirjam, Frijling Jessie L., Nawijn Laura, Koch Saskia B. J., Goslings J. Carel, Luitse Jan S., Biesheuvel Tessa H., Honig Adriaan, Veltman Dick J., Olff Miranda Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients Biological psychiatry 2017;81 (12):1030-1040 [PubMed]
  • Frijling Jessie L. Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals European journal of psychotraumatology 2017;8 (1):1302652 [PubMed]
  • Frijling Jessie L. Preventing PTSD with oxytoxin: Effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals 2017. 251p. ISBN 9789402805055. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Olff M., Veltman D. J.; Co-supervisor: van Zuiden M.)

2016

  • Koch Saskia B. J., van Zuiden Mirjam, Nawijn Laura, Frijling Jessie L., Veltman Dick J., Olff Miranda ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW Depression and anxiety 2016;33 (7):592-605 [PubMed]
  • Frijling Jessie L., van Zuiden Mirjam, Koch Saskia B. J., Nawijn Laura, Veltman Dick J., Olff Miranda Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals Social cognitive and affective neuroscience 2016;11 (2):327-336 [PubMed]
  • Koch Saskia Bj, van Zuiden Mirjam, Nawijn Laura, Frijling Jessie L., Veltman Dick J., Olff Miranda Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients Neuropsychopharmacology 2016;41 (6):1495-1504 [PubMed]
  • Frijling Jessie L., van Zuiden Mirjam, Koch Saskia B. J., Nawijn Laura, Veltman Dick J., Olff Miranda Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals Neuropsychopharmacology 2016;41 (5):1286-1296 [PubMed]
  • Nawijn Laura, van Zuiden Mirjam, Koch Saskia B. J., Frijling Jessie L., Veltman Dick J., Olff Miranda Intranasal oxytocin enhances neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls Psychoneuroendocrinology 2016;66:228-237 [PubMed]
  • Koch Saskia B. J., van Zuiden Mirjam, Nawijn Laura, Frijling Jessie L., Veltman Dick J., Olff Miranda Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder Neuropsychopharmacology 2016;41 (8):2041-2051 [PubMed]

2015

  • Olff Miranda, van Zuiden Mirjam, Koch Saskia B. J., Nawijn Laura, Frijling Jessie L., Veltman Dick J. Intranasal oxytocin: miracle cure after trauma? European journal of psychotraumatology 2015;6 (1):27631
  • Nawijn Laura, van Zuiden Mirjam, Frijling Jessie L., Koch Saskia B. J., Veltman Dick J., Olff Miranda Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia Neuroscience and biobehavioral reviews 2015;51:189-204 [PubMed]
  • Frijling J. L., van Zuiden M., Nawijn L., Koch S. B. J., Neumann I. D., Veltman D. J., Olff M. Salivary Oxytocin and Vasopressin Levels in Police Officers With and Without Post-Traumatic Stress Disorder Journal of neuroendocrinology 2015;27 (10):743-751 [PubMed]

2014

  • Frijling Jessie L., van Zuiden Mirjam, Koch Saskia B. J., Nawijn Laura, Goslings J. Carel, Luitse Jan S., Biesheuvel Tessa H., Honig Adriaan, Bakker Fred C., Denys Damiaan, Veltman Dick J., Olff Miranda Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial BMC psychiatry 2014;14 (1):92 [PubMed]
  • Koch Saskia B. J., van Zuiden Mirjam, Nawijn Laura, Frijling Jessie L., Veltman Dick J., Olff Miranda Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes Psychoneuroendocrinology 2014;40:242-256 [PubMed]
  • Olff Miranda, Koch Saskia B. J., Nawijn Laura, Frijling Jessie L., van Zuiden Mirjam, Veltman Dick J. Social support, oxytocin, and PTSD European journal of psychotraumatology 2014;5 (1):26513 [PubMed]

2013

  • Frijling Jessie L., van Zuiden Mirjam, Koch Saskia, Nawijn Laura, Veltman Dick, Olff Miranda Promoting resilience after trauma: clinical applications of intranasal oxytocin and affiliation development in preventing PTSDin: Martha Kent, Mary Davis, John Reich, editors. Handbook of Resilience: Approaches to Stress and Trauma. New York: Routledge; 2013. p. 299, ISBN 9780415818834
  • Frijling Jessie L., van Zuiden Mirjam, Koch Saskia B.J., Nawijn Laura, Veltman Dick J., Olff Miranda Promoting resilience after trauma clinical stimulation of the oxytocin systemin: The Resilience Handbook. Taylor and Francis AS; 2013. p. 299-308, ISBN 9780415699877
  • Olff Miranda, Frijling Jessie L., Kubzansky Laura D., Bradley Bekh, Ellenbogen Mark A., Cardoso Christopher, Bartz Jennifer A., Yee Jason R., van Zuiden Mirjam The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences Psychoneuroendocrinology 2013;38 (9):1883-1894 [PubMed]

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