J.L. Treur publications

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Publications J.L. Treur

Position
Research Associate
Main activities
Research
Specialisation
Genetics and substance use
Focus of research

My main research interests are the genetics of substance use (smoking, alcohol, cannabis) and the link between substance use and psychiatric outcomes. In 2016 I obtained my PhD at VU University in Amsterdam. During my PhD project I collected and analyzed data of thousands of twins and their family members to disentangle genetic from environmental influences on substance use. After obtaining my PhD, I received a NWO Rubicon grant to work as a post-doc at the University of Bristol in the United Kingdom. In Bristol I have specialized in a novel method that is increasingly being applied for causal inference, called Mendelian randomization. Mendelian randomization uses genetic variants predictive of an ‘exposure’ variable as an instrument, or proxy, to test causal effects on an ‘outcome’ variable. Because genes are randomly transmitted from parents to offspring, and an outcome cannot alter a person’s genes, this method suffers much less from confounding and reverse causality than conventional observational research. In 2018, I obtained a NWO VENI grant which has allowed me to join the department of Psychiatry at Amsterdam UMC to investigate the link between smoking and psychiatric traits with genetic methods (Mendelian randomization, genetic correlations, polygenic risk scores) as well as experimental methods (i.e. cognitive training to help smokers quit; in collaboration with the department of Developmental Psychology of the University of Amsterdam). 

2019

  • Pasman Joëlle A., Verweij Karin J. H., Gerring Zachary, Stringer Sven, Sanchez-Roige Sandra, Treur Jorien L., Abdellaoui Abdel, Nivard Michel G., Baselmans Bart M. L., Ong Jue-Sheng, Ip Hill F., van der Zee Matthijs D., Bartels Meike, Day Felix R., Fontanillas Pierre, Elson Sarah L., de Wit Harriet, Davis Lea K., MacKillop James, Derringer Jaime L., Branje Susan J. T., Hartman Catharina A., Heath Andrew C., van Lier Pol A. C., Madden Pamela A. F., Mägi Reedik, Meeus Wim, Montgomery Grant W., Oldehinkel A. J., Pausova Zdenka, Ramos-Quiroga Josep A., Paus Tomas, Ribases Marta, Kaprio Jaakko, Boks Marco P. M., Bell Jordana T., Spector Tim D., Gelernter Joel, Boomsma Dorret I., Martin Nicholas G., MacGregor Stuart, Perry John R. B., Palmer Abraham A., Posthuma Danielle, Munafò Marcus R., Gillespie Nathan A., Derks Eske M., Vink Jacqueline M. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability (Nature Neuroscience, (2018), 21, 9, (1161-1170), 10.1038/s41593-018-0206-1) Nature neuroscience 2019;22 (7):1196 [PubMed]
  • Gibson Mark, Munafò Marcus R., Taylor Amy E., Treur Jorien L. Evidence for Genetic Correlations and Bidirectional, Causal Effects Between Smoking and Sleep Behaviors Nicotine & tobacco research 2019;21 (6):731-738 [PubMed]
  • Allegrini Andrea G., Verweij Karin J. H., Abdellaoui Abdel, Treur Jorien L., Hottenga Jouke-Jan, Willemsen Gonneke, Boomsma Dorret I., Vink Jacqueline M. Genetic Vulnerability for Smoking and Cannabis Use: Associations With E-Cigarette and Water Pipe Use Nicotine & tobacco research 2019;21 (6):723-730 [PubMed]
  • Gillespie Nathan A., Pasman Joelle A., Treur Jorien L., Derkes Eske M., Verweij Karin J. H., Vink Jacqueline M. High-potency cannabis and incident psychosis: correcting the causal assumption Lancet. Psychiatry 2019;6 (6):464
  • Treur Jorien L., Demontis Ditte, Smith George Davey, Sallis Hannah, Richardson Tom G., Wiers Reinout W., Børglum Anders D., Verweij Karin J. H., Munafò Marcus R. Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization Addiction biology 2019 [PubMed]
  • Abdellaoui Abdel, Sanchez-Roige Sandra, Sealock Julia, Treur Jorien L., Dennis Jessica, Fontanillas Pierre, Elson Sarah, Nivard Michel G., Ip Hill Fung, van der Zee Matthijs, Baselmans Bart M. L., Hottenga Jouke Jan, Willemsen Gonneke, Mosing Miriam, Lu Yi, Pedersen Nancy L., Denys Damiaan, Amin Najaf, M van Duijn Cornelia, Szilagyi Ingrid, Tiemeier Henning, Neumann Alexander, Verweij Karin J. H., Cacioppo Stephanie, Cacioppo John T., Davis Lea K., Palmer Abraham A., Boomsma Dorret I. Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness Human molecular genetics 2019;28 (22):3853-3865 [PubMed]

2018

  • van den Broek Nina, Treur Jorien L., Larsen Junilla K., Verhagen Maaike, Verweij Karin J. H., Vink Jacqueline M. Causal associations between body mass index and mental health: A Mendelian randomisation study Journal of epidemiology and community health 2018;72 (8):708-710 [PubMed]
  • Treur Jorien L., Munafò Marcus R. Commentary on Kristjansson et al. (2018): Caffeine use during early adolescence as a possible risk factor for initiation of smoking and alcohol use Addiction (Abingdon, England) 2018;113 (9):1714-1715 [PubMed]
  • Treur Jorien L., Vink Jacqueline M., Boomsma Dorret I., Middeldorp Christel M. Corrigendum to “Spousal resemblance for smoking: Underlying mechanisms and effects of cohort and age” [Drug Alcohol Depend. 153 (2015) 221–228] (S0376871615002549) (10.1016/j.drugalcdep.2015.05.018)) Drug and alcohol dependence 2018;182:123 [PubMed]
  • Treur Jorien L., Rozema Andrea D., Mathijssen Jolanda J. P., van Oers Hans, Vink Jacqueline M. E-cigarette and waterpipe use in two adolescent cohorts: cross-sectional and longitudinal associations with conventional cigarette smoking European journal of epidemiology 2018;33 (3):323-334 [PubMed]
  • Pasman Joëlle A., Verweij Karin J. H., Gerring Zachary, Stringer Sven, Sanchez-Roige Sandra, Treur Jorien L., Abdellaoui Abdel, Nivard Michel G., Baselmans Bart M. L., Ong Jue-Sheng, Ip Hill F., van der Zee Matthijs D., Bartels Meike, Day Felix R., Fontanillas Pierre, Elson Sarah L., de Wit Harriet, Davis Lea K., MacKillop James, Derringer Jaime L., Branje Susan J. T., Hartman Catharina A., Heath Andrew C., van Lier Pol A. C., Madden Pamela A. F., Mägi Reedik, Meeus Wim, Montgomery Grant W., Oldehinkel A. J., Pausova Zdenka, Ramos-Quiroga Josep A., Paus Tomas, Ribases Marta, Kaprio Jaakko, Boks Marco P. M., Bell Jordana T., Spector Tim D., Gelernter Joel, Boomsma Dorret I., Martin Nicholas G., MacGregor Stuart, Perry John R. B., Palmer Abraham A., Posthuma Danielle, Munafò Marcus R., Gillespie Nathan A., Derks Eske M., Vink Jacqueline M. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia Nature neuroscience 2018;21 (9):1161-1170 [PubMed]
  • Verweij Karin J. H., Treur Jorien L., Vink Jacqueline M. Investigating causal associations between use of nicotine, alcohol, caffeine and cannabis: a two-sample bidirectional Mendelian randomization study Addiction (Abingdon, England) 2018;113 (7):1333-1338 [PubMed]
  • Treur Jorien L., Gibson Mark, Taylor Amy E., Rogers Peter J., Munafò Marcus R. Investigating genetic correlations and causal effects between caffeine consumption and sleep behaviours Journal of sleep research 2018;27 (5) [PubMed]
  • Treur Jorien L., Verweij Karin J. H., Abdellaoui Abdel, Fedko Iryna O., de Zeeuw Eveline L., Ehli Erik A., Davies Gareth E., Hottenga Jouke-Jan, Willemsen Gonneke, Boomsma Dorret I., Vink Jacqueline M. Testing familial transmission of smoking with two different research designs Nicotine & tobacco research 2018;20 (7):836-842 [PubMed]

2017

  • Verweij Karin J. H., Treur Jorien L., Vreeker Annabel, Brunt Tibor M., Willemsen Gonneke, Boomsma Dorret I., Vink Jacqueline M. Heritability of lifetime ecstasy use Drug and alcohol dependence 2017;178:66-69 [PubMed]