Publications L. ten Bloemendaal
- Position
- Support Staff
- Main activities
- Research
- Specialisation
- Gene therapy
- Focus of research
Gene Therapy.
The focus of the research is to develop Adeno Associated liver directed gene therapy to treat inherited unconjugated hyperbilirubinemia. This research is partly funded by the Dutch Najjar foundation. Succeslfull application of AAV in this patients will also enable us to use this strategy to treat other inherited liver diseases.
Amsterdam UMC Research Institutes
AMC departments
All publications
2021
- Shi Xiaoxia, Aronson Sem J., ten Bloemendaal Lysbeth, Duijst Suzanne, Bakker Robert S., de Waart Dirk R., Bortolussi Giulia, Collaud Fanny, Oude Elferink Ronald P., Muro Andrés F., Mingozzi Federico, Ronzitti Giuseppe, Bosma Piter J. Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients Molecular therapy. Methods & clinical development 2021;20:287-297
2020
- Aronson Sem J., Bakker Robert S., Moenis Sascha, van Dijk Remco, Bortolussi Giulia, Collaud Fanny, Shi Xiaoxia, Duijst Suzanne, ten Bloemendaal Lysbeth, Ronzitti Giuseppe, Muro Andrés F., Mingozzi Federico, Beuers Ulrich, Bosma Piter J. A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene Molecular therapy. Methods & clinical development 2020;18:250-258 [PubMed]
2019
- Aronson Sem J., Bakker Robert S., Shi Xiaoxia, Duijst Suzanne, ten Bloemendaal Lysbeth, de Waart Dirk R., Verheij Joanne, Ronzitti Giuseppe, Oude Elferink Ronald P., Beuers Ulrich, Paulusma Coen C., Bosma Piter J. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice Journal of hepatology 2019;71 (1):153-162 [PubMed]
2018
- Shi Xiaoxia, Ykema Matthew Ryan, Hazenoot Jaco, ten Bloemendaal Lysbeth, Mancini Irene, Odijk Machteld, de Haan Peter, Bosma Piter J. Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40 Molecular therapy. Methods & clinical development 2018;9:225-233 [PubMed]
2014
- Montenegro-Miranda P. S., Pichard V., Aubert D., ten Bloemendaal L., Duijst S., de Waart D. R., Ferry N., Bosma P. J. In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV Gene therapy 2014;21 (2):168-174 [PubMed]
2013
- Montenegro-Miranda Paula S., Pañeda Astrid, ten Bloemendaal Lysbeth, Duijst Suzanne, de Waart Dirk R., Aseguinolaza Gloria Gonzalez, Bosma Piter J. Adeno-associated viral vector serotype 5 poorly transduces liver in rat models PLoS ONE 2013;8 (12):e82597 [PubMed]
- Sokolović Aleksandar, Rodriguez-Ortigosa Carlos M., Bloemendaal Lysbeth Ten, Oude Elferink Ronald P. J., Prieto Jesús, Bosma Piter J. Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2013;1832 (6):697-704 [PubMed]
- van Dijk Remco, Montenegro-Miranda Paula S., Riviere Christel, Schilderink Ronald, ten Bloemendaal Lysbeth, van Gorp Jacqueline, Duijst Suzanne, de Waart Dirk R., Beuers Ulrich, Haisma Hidde J., Bosma Piter J. Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo Human gene therapy 2013;24 (9):807-813 [PubMed]
2012
- Montenegro-Miranda Paula S., Sneitz Nina, de Waart D. Rudi, ten Bloemendaal Lysbeth, Duijst Suzanne, de Knegt Robert J., Beuers Ulrich, Finel Moshe, Bosma Piter J. Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (8):1223-1229 [PubMed]
2011
- Montenegro-Miranda Paula, ten Bloemendaal Lysbeth, Kunne Cindy, de Waart Dirk R., Bosma Piter J. Mycophenolate Mofetil Impairs Transduction of Single-Stranded Adeno-Associated Viral Vectors Human gene therapy 2011;22 (5):605-612 [PubMed]
2009
- Deurholt Tanja, van Til Niek P., Chhatta Aniska A., ten Bloemendaal Lysbeth, Schwartlander Ruth, Payne Catherine, Plevris John N., Sauer Igor M., Chamuleau Robert A. F. M., Oude Elferink Ronald P. J., Seppen Jurgen, Hoekstra Ruurdtje Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes BMC biotechnology 2009;9 (1):89 [PubMed]
2007
- Poyck Paul P. C., Hoekstra Ruurdtje, Chhatta Aniska, ten Bloemendaal Lysbeth, van Wijk Albert C. W. A., Galavotti Daniele, van Gulik Thomas M., Chamuleau Robert A. F. M. Time-related analysis of metabolic liver functions, cellular morphology, and gene expression of hepatocytes cultured in the bioartificial liver of the Academic Medical Center in Amsterdam (AMC-BAL) Tissue engineering 2007;13 (6):1235-1246 [PubMed]
2006
- Hoekstra Ruurdtje, Deurholt Tanja, ten Bloemendaal Lysbeth, Desille Mireille, van Wijk Albert C. W. A., Clement Bruno, Oude Elferink Ronald P. J., van Gulik Thomas M., Chamuleaut Robert A. F. M. Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives Cell transplantation 2006;15 (5):423-433 [PubMed]
- Deurholt Tanja, ten Bloemendaal Lysbeth, Chhatta Aniska A., van Wijk Albert C. W. A., Weijer Kees, Seppen Jurgen, Elferink Ronald P. J. Oude, Chamuleau Robert A. F. M., Hoekstra Ruurdtje In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions Cell transplantation 2006;15 (8-9):811-822 [PubMed]
2005
- Hoekstra Ruurdtje, Deurholt Tanja, Poyck Paul P. C., ten Bloemendaal Lysbeth, Chhatta Aniska A. Increased reproducibility of quantitative reverse transcriptase-PCR Analytical biochemistry 2005;340 (2):376-379 [PubMed]
- Poyck Paul P. C., Hoekstra Ruurdtje, van Wijk Albert C. W. A., ten Bloemendaal Lysbeth, Chamuleau Robert A. F. M., van Gulik Thomas M. Mild hypothermic preservation for transport purposes of the AMC bioartificial liver charged with porcine hepatocytes Transplantation 2005;80 (9):1153-1160 [PubMed]