- Wijnberge Marije, Geerts Bart F, Hol Liselotte, Lemmers Nikki, Mulder Marijn P, Berge Patrick, Schenk Jimmy, Terwindt Lotte E, Hollmann Markus W, Vlaar Alexander P, Veelo Denise P Effect of a Machine Learning-Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery: The HYPE Randomized Clinical Trial JAMA 2020;323 (11):1052-1060 [PubMed]
- Veelo Denise P., Gisbertz Suzanne S., Binnekade Jan M., Hannivoort Rebekka A., Bosman Johanneke A., Geerts Bart F., Blobner Manfred, van Berge Henegouwen Mark I., Hollmann Markus W. Perfusion continue versus bolus intermittent sur demande de rocuronium pour procurer une relaxation neuromusculaire profonde aux patients subissant une œsophagectomie par thoraco-laparoscopie : une étude clinique randomisée contrôlée (DEPTH) Canadian journal of anaesthesia = Journal canadien d'anesthésie 2019:1062–1074 [PubMed]
- Geerts B. F., Veelo D. P. Postoperative fluid therapy on the ward: another job for anaesthetists? British journal of anaesthesia 2018;120 (2):205-206 [PubMed]
- Vlaar Alexander P. J., Veelo Denise P. The First Steps in Understanding of Transfusion-Associated Circulatory Overload-We Are on a "Roll" Critical care medicine 2018;46 (4):650-651 [PubMed]
- Veelo Denise P., van Berge Henegouwen Mark I., Ouwehand Kirsten S., Geerts Bart F., Anderegg Maarten C. J., van Dieren Susan, Preckel Benedikt, Binnekade Jan M., Gisbertz Suzanne S., Hollmann Markus W. Effect of goal-directed therapy on outcome after esophageal surgery: A quality improvement study PLoS ONE 2017;12 (3):e0172806 [PubMed]
Current projects and research experience
2017- now Project leader (Co-chair with Bart Geerts and Alexander Vlaar) of a research group into hemodynamics in the perioperative and ICU setting. Topics: outcome optimization, basic physiological techniques and advanced (non-invasive) pulse wave analysis, hypotension, fluids, implementation and development of machine learning algorithms.
We lead:
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- Nine PhD students (1 Technical medicine)
- One post-doctoral fellow (Technical Medicine).
- Several scientific internships (> 20) to Medical and Technical Medicine (M2 and M3) students.
2013- 2017 Several research projects regarding implementing and applying strategies to assess and optimise perioperative outcome in high-risk (surgical) patients. Supervisor: Prof. Markus W. Hollmann, Department of Anaesthesiology, Academic Medical Center Amsterdam.
- Evaluating intraoperative changes in microcirculation in the neo-oesophagus and liver.
- Fluid and pain management in patients after pancreatic and liver surgery.
- Implementation of goal-directed hemodynamic therapy in high risk surgery patients.
- Fluid and haemodynamic optimization strategies.
- Innovative projects regarding novel haemodynamic monitoring devices and development of treatment and machine learning algorithms.
2005-2010 PhD project with thesis: “artificial airways and mechanical ventilation of critically ill patients” Promotor: Prof. Marcus J. Schultz. Department of Intensive Care Medicine, Academic Medical Center Amsterdam.
Awards
2015 Pearl award from the Netherlands Organisation for Health Research and Development (ZonMW): contribution to national healthcare innovation with our business case tools for implementation of goal-directed fluid therapy in the Netherlands.
Impact
More than 50 peer-reviewed publications
H-index 15
RG-score 35.35
Supervision Bachelor students: 2
Supervision Master students: 10
Co-promotor PhD students: 6
Supervision Postdoc: 1
Prof. MD PhD M.J. Schultz (Prevention and treatment of organ failure in intensive care medicine)
Prof. MD PhD M.W. Hollmann (Organprotection)
Prof. MA MD PhD B. Preckel (Patient safety, procedural sedation, cardiovascular protection, optimizing perioperative metabolism, cerebral perfusion, Wireless Monitoring)