MEng PhD C.J. Zuurbier publications


Publications MEng PhD C.J. Zuurbier

Research Associate
Main activities
Education, Research
Research into cardiovascular physiology
Focus of research

Cardiovascular disease remains the number one cause of death, not only in the chronic human condition (cardiac infarction, heart failure, diabetes), but also in many acute traumatic hospital conditions (cardiac by-pass surgery, PTCI and acute myocardial infarction, cardiogenic shock, sepsis). Our research is directed at the understanding of the 1) mechanisms through which current novel succesfull diabetes medicine (SGLT2 inhibitors) reduce cardiovascular events (heart failure, diastolic dysfunction, cardiac infarction) and 2) crucial cellular mechanisms underlying death/survival programs of the heart cell in these acute traumatic hospital conditions conditions and at the development of treatments to push the cell death/survival programs into the direction of survival.

In our current models, with emphasis on its translation to the clinic and human condition (taking into account co-morbidities, drugs commonly used in human treatment and clinical relevant anesthetic regimens), we primarily focus on 1) unraveling of the working mechanisms of SGLT2 inhibitors, and 2) the decisive role that mitochondria play in the setting of cardiac death induced by periods of ischemia (lack of oxygen, blood flow). Attention is especially given to 1) empagliflozin, and 2) the glycolytic enzyme hexokinase II, of which its binding to mitochondria is highly regulated and is of paramount importance to protect mitochondria and thereby combat cardiac cell death in almost all of the above conditions.












  • Penna Claudia, Andreadou Ioanna, Aragno Manuela, Beauloye Christophe, Bertrand Luc, Lazou Antigone, Falcão-Pires Ines, Bell Robert, Zuurbier Coert J., Pagliaro Pasquale, Hausenloy Derek J. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols British journal of pharmacology 2020 [PubMed]


  • Uthman Laween, Nederlof Rianne, Eerbeek Otto, Baartscheer Antonius, Schumacher Cees, Buchholtz Ninée, Hollmann Markus W, Coronel Ruben, Weber Nina C, Zuurbier Coert J Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts Cardiovascular research 2019;115 (10):1533-1545 [PubMed]
  • de Lucia Claudio, Sardu Celestino, Metzinger Laurent, Zuurbier Coert J. Editorial: Diabetes and heart failure: Pathogenesis and novel therapeutic approaches Frontiers in physiology 2019;10:253 [PubMed]
  • Uthman Laween, Homayr Anna, Juni Rio P., Spin Eva L., Kerindongo Raphaela, Boomsma Marleen, Hollmann Markus W., Preckel Benedikt, Koolwijk Pieter, van Hinsbergh Victor W. M., Zuurbier Coert J., Albrecht Martin, Weber Nina C. Empagliflozin and Dapagliflozin Reduce ROS Generation and Restore NO Bioavailability in Tumor Necrosis Factor α-Stimulated Human Coronary Arterial Endothelial Cells Cellular physiology and biochemistry 2019;53 (5):865-886 [PubMed]
  • Zuurbier Coert J. Ketamine-(Dex)Medetomidine, Hyperglycemia, Glycocalyx, and Vascular Permeability Anesthesia and analgesia 2019;129 (3):e102 [PubMed]
  • Zuurbier Coert J. NLRP3 Inflammasome in Cardioprotective Signaling Journal of cardiovascular pharmacology 2019;74 (4):271-275 [PubMed]
  • Klanderman Robert B., Bosboom Joachim J., Maas Adrie A. W., Roelofs Joris J. T. H., de Korte Dirk, van Bruggen Robin, van Buul Jaap D., Zuurbier Coert J., Veelo Denise P., Hollmann Markus W., Vroom Margreeth B., Juffermans Nicole P., Geerts Bart F., Vlaar Alexander P. J. Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model Transfusion 2019;59 (12):3617-3627 [PubMed]
  • Wirtz Mathijs R., Jurgens Jordy, Zuurbier Coert J., Roelofs Joris J. T. H., Spinella Philip C., Muszynski Jennifer A., Carel Goslings J., Juffermans Nicole P. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion Transfusion 2019;59 (1):134-145 [PubMed]


  • Uthman Laween, Baartscheer Antonius, Bleijlevens Boris, Schumacher Cees A., Fiolet Jan W. T., Koeman Anneke, Jancev Milena, Hollmann Markus W., Weber Nina C., Coronel Ruben, Zuurbier Coert J. Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation Diabetologia 2018;61 (3):722-726 [PubMed]
  • Kors Lotte, Rampanelli Elena, Stokman Geurt, Butter Loes M., Held Ntsiki M., Claessen Nike, Larsen Per W. B., Verheij Joanne, Zuurbier Coert J., Liebisch Gerhard, Schmitz Gerd, Girardin Stephen E., Florquin Sandrine, Houtkooper Riekelt H., Leemans Jaklien C. Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (5):1883-1895 [PubMed]
  • Uthman Laween, Baartscheer Antonius, Schumacher Cees A, Fiolet Jan W T, Kuschma Marius C, Hollmann Markus W, Coronel Ruben, Weber Nina C, Zuurbier Coert J Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients Frontiers in physiology 2018;9:1575 [PubMed]
  • Ergin Bulent, Zuurbier Coert J., Kapucu Aysegul, Ince Can Divergent Effects of Hypertonic Fluid Resuscitation on Renal Pathophysiological and Structural Parameters in Rat Model of Lower Body Ischemia/Reperfusion-Induced Sterile Inflammation Shock (Augusta, Ga.) 2018;50 (6):655-663 [PubMed]
  • Aehling C., Weber N. C., Zuurbier C. J., Preckel B., Galmbacher R., Stefan K., Hollmann M. W., Popp E., Knapp J. Effects of combined helium pre/post-conditioning on the brain and heart in a rat resuscitation model Acta anaesthesiologica Scandinavica 2018;62 (1):63-74 [PubMed]
  • Smit Kirsten F., Konkel Moritz, Kerindongo Raphaela, Landau Maximilian A., Zuurbier Coert J., Hollmann Markus W., Preckel Benedikt, Nieuwland Rienk, Albrecht Martin, Weber Nina C. Helium alters the cytoskeleton and decreases permeability in endothelial cells cultured in vitro through a pathway involving Caveolin-1 Scientific reports 2018;8 (1) [PubMed]
  • van Weeghel Michel, Abdurrachim Desiree, Nederlof Rianne, Argmann Carmen A., Houtkooper Riekelt H., Hagen Jacob, Nabben Miranda, Denis Simone, Ciapaite Jolita, Kolwicz Stephen C., Lopaschuk Gary D., Auwerx Johan, Nicolay Klaas, Des Rosiers Christine, Wanders Ronald J., Zuurbier Coert J., Prompers Jeanine J., Houten Sander M. Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B Cardiovascular research 2018;114 (10):1324-1334 [PubMed]
  • Weber Nina C., Zuurbier Coert J., Hollmann Markus W. Remote ischaemic preconditioning of the lung: From bench to bedside - Are we there yet? Journal of thoracic disease 2018;10 (1):98-101 [PubMed]
  • Ergin Bulent The renal microcirculation as a target for the treatment of acute kidney injury in models of critical illness 2018. ISBN 9789463800518. [UvA Dissertations Online] Erasmus University Rotterdam: ErasmusMC. (Supervisors: Gommers D. A. M. P. J., Ince Can, Zuurbier C. J.)


  • Nederlof Rianne, Denis Simone, Lauzier Benjamin, Rosiers Christine Des, Laakso Markku, Hagen Jacob, Argmann Carmen, Wanders Ronald, Houtkooper Riekelt H., Hollmann Markus W., Houten Sander M., Zuurbier Coert J. Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart Metabolism: clinical and experimental 2017;72:66-74 [PubMed]
  • Nederlof Rianne, Weber Nina C., Juffermans Nicole P., de Mol Bas A. M. J., Hollmann Markus W., Preckel Benedikt, Zuurbier Coert J. A randomized trial of remote ischemic preconditioning and control treatment for cardioprotection in sevoflurane-anesthetized CABG patients BMC anesthesiology 2017;17 (1):51 [PubMed]
  • Nederlof Rianne, van den Elshout Mark A. M., Koeman Anneke, Uthman Laween, Koning Iris, Eerbeek Otto, Weber Nina C., Hollmann Markus W., Zuurbier Coert J. Cyclophilin D ablation is associated with increased end-ischemic mitochondrial hexokinase activity Scientific reports 2017;7 (1):12749 [PubMed]
  • Baartscheer Antonius, Schumacher Cees A., Wüst Rob C. I., Fiolet Jan W. T., Stienen Ger J. M., Coronel Ruben, Zuurbier Coert J. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits Diabetologia 2017;60 (3):568-573 [PubMed]
  • Jong Willeke M. C. Inflammation and acute myocardial ischemia-reperfusion injury using a closed-chest mouse model 2017. 181p. ISBN 9789462958104. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., de Winter R. J.; Co-supervisors: ten Cate H., Zuurbier C. J.)
  • Nederlof Rianne Mitochondrial hexokinase and ischemic sensitivity and metabolism of the heart 2017. 259p. ISBN 9789492801098. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Hollmann M. W., Preckel B.; Co-supervisors: Zuurbier C. J., Hauck-Weber N. C.)
  • Stokman Geurt, Kors Lotte, Bakker Pieter J., Rampanelli Elena, Claessen Nike, Teske Gwendoline J. D., Butter Loes, van Andel Harmen, van den Bergh Weerman Marius A., Larsen Per W. B., Dessing Mark C., Zuurbier Coert J., Girardin Stephen E., Florquin Sandrine, Leemans Jaklien C. NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity Journal of experimental medicine 2017;214 (8):2405-2420 [PubMed]
  • Smit Kirsten F. Organ protection by the noble gas helium 2017. 237p. ISBN 9789492683212. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Preckel B., Hollmann M. W.; Co-supervisors: Hauck-Weber N. C., Zuurbier C. J.)


  • Flick Moritz, Albrecht Martin, Oei Gezina T. M. L., Steenstra Renske, Kerindongo Raphaela P., Zuurbier Coert J., Patel Hemal H., Hollmann Markus W., Preckel Benedikt, Weber Nina C. Helium postconditioning regulates expression of caveolin-1 and -3 and induces RISK pathway activation after ischaemia/reperfusion in cardiac tissue of rats European journal of pharmacology 2016;791:718-725 [PubMed]
  • Mariotti E., Orton M. R., Eerbeek O., Ashruf J. F., Zuurbier C. J., Southworth R., Eykyn T. R. Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart NMR in biomedicine 2016;29 (4):377-386 [PubMed]
  • Jong Willeke M. C., ten Cate Hugo, Linnenbank André C., de Boer Onno J., Reitsma Pieter H., de Winter Robbert J., Zuurbier Coert J. Reduced acute myocardial ischemia-reperfusion injury in IL-6-deficient mice employing a closed-chest model Inflammation research 2016;65 (6):489-499 [PubMed]
  • Nederlof Rianne, Gürel-Gurevin Ebru, Eerbeek Otto, Xie Chaoqin, Deijs G. Sjoerd, Konkel Moritz, Hu Jun, Weber Nina C., Schumacher Cees A., Baartscheer Antonius, Mik Egbert G., Hollmann Markus W., Akar Fadi G., Zuurbier Coert J. Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart Journal of physiology and biochemistry 2016;73 (3):323-333 [PubMed]
  • Yndestad Arne, Sandanger Øystein, Jong Willeke M. C., Aukrust Pål, Zuurbier Coert J. Response to letter from Toldo et al. on "NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective" Biochemical and biophysical research communications 2016;474 (2):328-329 [PubMed]


  • El Messaoudi Saloua, Nederlof Rianne, Zuurbier Coert J., van Swieten Henry A., Pickkers Peter, Noyez Luc, Dieker Hendrik-Jan, Coenen Marieke J., Donders A. Rogier T., Vos Annemieke, Rongen Gerard A., Riksen Niels P. Effect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial Lancet. Diabetes and endocrinology 2015;3 (8):615-623 [PubMed]
  • Balestra Gianmarco M., Mik Egbert G., Eerbeek Otto, Specht Patricia A. C., van der Laarse Willem J., Zuurbier Coert J. Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure? Respiratory research 2015;16 (1):6 [PubMed]
  • Bakermans Adrianus J., Abdurrachim Desiree, van Nierop Bastiaan J., Koeman Anneke, van der Kroon Inge, Baartscheer Antonius, Schumacher Cees A., Strijkers Gustav J., Houten Sander M., Zuurbier Coert J., Nicolay Klaas, Prompers Jeanine J. In vivo mouse myocardial P-31 MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations NMR in biomedicine 2015;28 (10):1218-1227 [PubMed]
  • Zuurbier Coert J., Koeman Anneke, Janssen Ben J. Letter to the editor: Ketamine-only versus isoflurane effects on murine cardiac function: comparison at similar depths of anesthesia? American journal of physiology. Heart and circulatory physiology 2015;309 (12):H2160 [PubMed]
  • Ashruf Jesse Feisal Myocardial microcirculation and mitochondrial energetics in the isolated rat heart 2015. 152p. ISBN 9789491715075. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Ince C.; Co-supervisors: Zuurbier C. J., Milstein D. M. J.)
  • Weber Nina C., Riedemann Isabelle, Smit Kirsten F., Zitta Karina, van de Vondervoort Djai, Zuurbier Coert J., Hollmann Markus W., Preckel Benedikt, Albrecht Martin Plasma from human volunteers subjected to remote ischemic preconditioning protects human endothelial cells from hypoxia-induced cell damage Basic research in cardiology 2015;110 (2):17 [PubMed]


  • Zuurbier Coert J., Heinen Andre, Koeman Anneke, Stuifbergen Roy, Hakvoort Theodorus B. M., Weber Nina C., Hollmann Markus W. Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: a case study with folic acid Journal of translational medicine 2014;12 (1):325 [PubMed]
  • Jong Willeke M. C., Leemans Jaklien C., Weber Nina C., Juffermans Nicole P., Schultz Marcus J., Hollmann Markus W., Zuurbier Coert J. Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression International journal of cardiology 2014;177 (1):41-43 [PubMed]
  • Zuurbier Coert J., Koeman Anneke, Houten Sander M., Hollmann Markus W., Florijn Wouter J. Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, metabolic, and inflammatory perturbations Experimental biology and medicine (Maywood, N.J.) 2014;239 (6):737-746 [PubMed]
  • Nederlof Rianne, Eerbeek Otto, Hollmann Markus W., Southworth Richard, Zuurbier Coert J. Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart British journal of pharmacology 2014;171 (8):2067-2079 [PubMed]
  • van Golen Rowan F., Reiniers Megan J., Vrisekoop Nienke, Zuurbier Coert J., Olthof Pim B., van Rheenen Jacco, van Gulik Thomas M., Parsons Barry J., Heger Michal The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury Antioxidants & redox signaling 2014;21 (7):1098-1118 [PubMed]


  • Jong Willeke M. C., Zuurbier Coert J. A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury? Cardiovascular research 2013;99 (1):226 [PubMed]
  • Eskens Bart J. M., Zuurbier Coert J., van Haare Judith, Vink Hans, van Teeffelen Jurgen W. G. E. Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice Cardiovascular diabetology 2013;12 (1):175 [PubMed]
  • Gurel Ebru, Ustunova Savas, Kapucu Aysegul, Yilmazer Nadim, Eerbeek Otto, Nederlof Rianne, Hollmann Markus W., Demirci-Tansel Cihan, Zuurbier Coert J. Hexokinase cellular trafficking in ischemia-reperfusion and ischemic preconditioning is altered in type I diabetic heart Molecular biology reports 2013;40 (7):4153-4160 [PubMed]
  • Nederlof Rianne, Xie Chaoqin, Eerbeek Otto, Koeman Anneke, Milstein Dan M. J., Hollmann Markus W., Mik Egbert G., Warley Alice, Southworth Richard, Akar Fadi G., Zuurbier Coert J. Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia Circulation research 2013;112 (2):e8-13 [PubMed]


  • Sachs Norman, Claessen Nike, Aten Jan, Kreft Maaike, Teske Gwendoline J. D., Koeman Anneke, Zuurbier Coert J., Janssen Hans, Sonnenberg Arnoud Blood pressure influences end-stage renal disease of Cd151 knockout mice Journal of clinical investigation 2012;122 (1):348-358 [PubMed]
  • Zuurbier Coert J., Jong Willeke M. C., Eerbeek Otto, Koeman Anneke, Pulskens Wilco P., Butter Loes M., Leemans Jaklien C., Hollmann Markus W. Deletion of the Innate Immune NLRP3 Receptor Abolishes Cardiac Ischemic Preconditioning and Is Associated with Decreased Il-6/STAT3 Signaling PLoS ONE 2012;7 (7):e40643 [PubMed]
  • Snoek S. A., Dhawan S., van Bree S. H., Cailotto C., van Diest S. A., Duarte J. M., Stanisor O. I., Hilbers F. W., Nijhuis L., Koeman A., van den Wijngaard R. M., Zuurbier C. J., Boeckxstaens G. E., de Jonge W. J. Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model Neurogastroenterology and motility 2012;24 (2):172-E91 [PubMed]
  • Smeele Kirsten M., Eerbeek Otto, Schaart Gert, Koeman Anneke, Bezemer Rick, Nelson Jessica K., Ince Can, Nederlof Rianne, Boek Maxim, Laakso Markku, de Haan Arnold, Drost Maarten R., Hollmann Markus W., Zuurbier Coert J. Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis Journal of applied physiology (Bethesda, Md. 2012;113 (4):608-618 [PubMed]
  • Smeele Kirsten M. A. The role of mitochondral Hexokinase II in ischemia-reperfusion damage 2012. 195p. ISBN 9789088914355. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Hollmann M. W.; Co-supervisors: Zuurbier C. J., Eerbeek O.)


  • Smeele Kirsten M. A., Southworth Richard, Wu Rongxue, Xie Chaoqin, Nederlof Rianne, Warley Alice, Nelson Jessica K., van Horssen Pepijn, van den Wijngaard Jeroen P., Heikkinen Sami, Laakso Markku, Koeman Anneke, Siebes Maria, Eerbeek Otto, Akar Fadi G., Ardehali Hossein, Hollmann Markus W., Zuurbier Coert J. Disruption of Hexokinase II-Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis Circulation research 2011;108 (10):1165-9 [PubMed]
  • Mik Egbert G. Measuring microvascular and mitochondrial oxygen tension. Novel techniques for studying tissue oxygeneration 2011. 157p. ISBN 9789461081360. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Ince C.; Co-supervisor: Zuurbier C. J.)
  • Wu Rongxue, Smeele Kirsten M., Wyatt Eugene, Ichikawa Yoshihiko, Eerbeek Otto, Sun Lin, Chawla Kusum, Hollmann Markus W., Nagpal Varun, Heikkinen Sami, Laakso Markku, Jujo Kentaro, Wasserstrom J. Andrew, Zuurbier Coert J., Ardehali Hossein Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury Circulation research 2011;108 (1):60-U128 [PubMed]
  • Smeele Kirsten M., ter Horst Leontien H., Koeman Anneke, Heikkinen Sami, Laakso Markku, Weber Nina C., Hollmann Markus W., Zuurbier Coert J. The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury Laboratory animals 2011;45 (3):160-166 [PubMed]


  • Smeele Kirsten M., Eerbeek Otto, Koeman Anneke, Bezemer Rick, Ince Can, Heikkinen Sami, Laakso Markku, de Haan Arnold, Schaart Gert, Drost Maarten R., Hollmann Markus W., Zuurbier Coert J. Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice Pflugers Archiv 2010;459 (5):705-712 [PubMed]
  • Aslami Hamid, Heinen André, Roelofs Joris J. T. H., Zuurbier Coert J., Schultz Marcus J., Juffermans Nicole P. Suspended animation inducer hydrogen sulfide is protective in an in vivo model of ventilator-induced lung injury Intensive care medicine 2010;36 (11):1946-1952 [PubMed]


  • Zuurbier Coert J., Bos Albert P., van Wezel Harry B. Glycaemic control in paediatric critical care Lancet 2009;373 (9673):1423 [PubMed]
  • Zuurbier Coert J. Insulin as ischaemic preconditioning-mimetic Acta physiologica (Oxford, England) 2009;195 (2):203 [PubMed]
  • Gurel Ebru, Smeele Kirsten M., Eerbeek Otto, Koeman Anneke, Demirci Cihan, Hollmann Markus W., Zuurbier Coert J. Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion Journal of applied physiology (Bethesda, Md. 2009;106 (6):1909-1916 [PubMed]
  • Zuurbier C. J., Smeele K. M. A., Eerbeek O. Mitochondrial hexokinase and cardioprotection of the intact heart Journal of bioenergetics and biomembranes 2009;41 (2):181-185 [PubMed]
  • Mik Egbert G., Ince Can, Eerbeek Otto, Heinen Andre, Stap Jan, Hooibrink Berend, Schumacher Cees A., Balestra Gianmarco M., Johannes Tanja, Beek Johan F., Nieuwenhuis Ab F., van Horssen Pepijn, Spaan Jos A., Zuurbier Coert J. Mitochondrial oxygen tension within the heart Journal of molecular and cellular cardiology 2009;46 (6):943-951 [PubMed]
  • Gurel Ebru Role of mitochondrial hexokinase in ischemia-reperfusion injury of the diabetic hearts.l: 2009. [UvA Dissertations Online] Universiteit van Istanbul: -. (Supervisor: Demirci C.; Co-supervisor: Zuurbier C. J.)


  • Zuurbier Coert J., Keijzers Peter J. M., Koeman Anneke, van Wezel Harry B., Hollmann Markus W. Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats Anesthesia and analgesia 2008;106 (1):135-142 [PubMed]
  • Zuurbier C. J., van Wezel H. B. Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2008;22 (2):125-131 [PubMed]
  • Heinen Andre, Huhn Ragnar, Smeele Kirsten M. A., Zuurbier Coert J., Schlack Wolfgang, Preckel Benedikt, Weber Nina C., Hollmann Markus W. Helium-induced preconditioning in young and old rat heart: impact of mitochondrial Ca(2+) -sensitive potassium channel activation Anesthesiology 2008;109 (5):830-836 [PubMed]
  • Mik Egbert G., Johannes Tanja, Zuurbier Coert J., Heinen Andre, Houben-Weerts Judith H. P. M., Balestra Gianmarco M., Stap Jan, Beek Johan F., Ince Can In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique Biophysical journal 2008;95 (8):3977-3990 [PubMed]
  • Zuurbier C. J., Hoek F. J., van Dijk J., Abeling N. G., Meijers J. C. M., Levels J. H. M., de Jonge E., de Mol B. A., van Wezel H. B. Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery British journal of anaesthesia 2008;100 (4):442-450 [PubMed]
  • Heinen André, Huhn Ragnar, Hollmann Markus W., Preckel Benedikt, Zuurbier Coert J., Schlack Wolfgang, Frässdorf Jan, Weber Nina C. Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart European journal of pharmacology 2008;595 (1-3):58-64 [PubMed]


  • van Wezel H. B., Zuurbier C. J., de Jonge E., van Dam E. W. C. M., van Dijk J., Endert E., de Mol B. A., Fliers E. Differential effects of a perioperative hyperinsulinemic normoglycemic clamp on the neurohumoral stress response during coronary artery surgery Journal of clinical endocrinology and metabolism 2006;91 (10):4144-4153 [PubMed]
  • van Wezel H. B., Zuurbier C. J., van Dijk J., Hoek F. J., de Jonge E., de Mol B. A. Hyperinsulinaemic normoglycaemic clamp in coronary artery surgery British journal of anaesthesia 2006;96 (1):140-141 [PubMed]


  • Visser L., Zuurbier C. J., Hoek F. J., Opmeer B. C., de Jonge E., de Mol B. A. J. M., van Wezel H. B. Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: effects on inflammatory response during coronary artery surgery British journal of anaesthesia 2005;95 (4):448-457 [PubMed]
  • Zuurbier Coert J., Eerbeek Otto, Meijer Alfred J. Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution American journal of physiology. Heart and circulatory physiology 2005;289 (1):H496-H499 [PubMed]
  • Zuurbier Coert J., Demirci Cihan, Koeman Anneke, Vink Hans, Ince Can Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells Journal of applied physiology (Bethesda, Md. 2005;99 (4):1471-1476 [PubMed]


  • Zuurbier C. J., Eerbeek O., Goedhart P. T., Struys E. A., Verhoeven N. M., Jakobs C., Ince C. Inhibition of the pentose phosphate pathway decreases ischemia-reperfusion-induced creatine kinase release in the heart Cardiovascular research 2004;62 (1):145-153 [PubMed]
  • Zuurbier C. J., Emons V. M., Koeman A., Ince C. Mouse anesthesia in relation to optimal hemodynamicsin: C. Ince, editors. The physiological genomics of the critically ill mouse. Boston: Kluwer Academic Publishers; 2004. p. 23-34, ISBN 9781402076411
  • Visser Liesbeth, Zuurbier Coert J., van Wezel Harry B., van der Vusse Ger J., Hoek Frans J. Overestimation of plasma nonesterified fatty acid concentrations in heparinized blood Circulation 2004;110 (13):e328 [PubMed]
  • Eerbeek Otto, Mik Egbert G., Zuurbier Coert J., van 't Loo Martijn, Donkersloot Cees, Ince Can Ratiometric intracellular calcium imaging in the isolated beating rat heart using indo-1 fluorescence Journal of applied physiology (Bethesda, Md. 2004;97 (6):2042-2050 [PubMed]


  • Zuurbier Coert Jozef, Kruyver Bart, Eerbeek Otto, Mik Egbert Gezinus, Ince Can Commonly used numbers of microspheres affect cardiac vascular resistance Journal of cardiovascular pharmacology 2003;41 (2):223-232 [PubMed]


  • Jong Willeke M. C., Zuurbier Coert J., de Winter Robbert J., van den Heuvel Danyel A. F., Reitsma Pieter H., ten Cate Hugo, Ince Can Fentanyl-fluanisone-midazolam combination results in more stable hemodynamics than does urethane alpha-chloralose and 2,2,2-tribromoethanol in mice CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE 2002;41 (3):28-32 [PubMed]
  • Zuurbier Coert J., Emons Vanessa M., Ince Can Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain American journal of physiology. Heart and circulatory physiology 2002;282 (6):H2099-H2105 [PubMed]
  • Zuurbier C. J., Ince C. Post-ischaemic changes in the response time of oxygen consumption to demand in the isolated rat heart are mediated partly by calcium and glycolysis Pflugers Archiv 2002;443 (5-6):908-916 [PubMed]


  • Mechanical ventilation of mice Basic research in cardiology 2000;95 (6):510-520 [PubMed]


  • Dynamics of tissue oxygenation in isolated rabbit heart as measured with near-infrared spectroscopy American journal of physiology 1999;276 (5 Part 2):H1616-H1624 [PubMed]
  • Functional heterogeneity of oxygen supply-consumption ratio in the heart Cardiovascular research 1999;44 (3):488-497 [PubMed]
  • Increased hypoxic stress decreases AMP hydrolysis in rabbit heart Cardiovascular research 1999;44 (2):333-343 [PubMed]


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