MSc J.M. Donkers publications


Publications MSc J.M. Donkers

Other Academic Staff
Main activities
Targetting bile acid transport for metabolic diseases
Focus of research

I am a PhD student at the Tytgat Institute for liver and intestinal research. My research project targets the molecular consequences of bile acid signalling in metabolic diseases, mainly tyoe 2 diabetes and obesity.


  • Roscam Abbing Reinout L. P., Slijepcevic Davor, Donkers Joanne M., Havinga Rick, Duijst Suzanne, Paulusma Coen C., Kuiper Johan, Kuipers Folkert, Groen Albert K., Oude Elferink Ronald P. J., van de Graaf Stan F. J. Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice Hepatology (Baltimore, Md.) 2020;71 (1):247-258 [PubMed]


  • Donkers Joanne M., Roscam Abbing Reinout L.P., van de Graaf Konstantijn Developments in bile salt based therapies: A critical overview Biochemical pharmacology 2019;161:1-13 [PubMed]
  • Qu Changbo, Li Yang, Li Yunlong, Yu Peifa, Li Pengfei, Donkers Joanne M., van de Graaf Stan F. J., de Man Robert A., Peppelenbosch Maikel P., Pan Qiuwei FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis Antiviral research 2019;170 [PubMed]
  • Donkers Joanne, Appelman Monique, van de Graaf Konstantijn Mechanistic insights into the inhibition of NTCP by myrcludex B JHEP Reports 2019;1 (4):278-285
  • Donkers Joanne M., Kooijman Sander, Slijepcevic Davor, Kunst Roni F., Roscam Abbing Reinout L. P., Haazen Lizette, de Waart Dirk R., Levels Johannes H. M., Schoonjans Kristina, Rensen Patrick C. N., Oude Elferink Ronald P. J., van de Graaf Stan F. J. NTCP deficiency in mice protects against obesity and hepatosteatosis JCI insight 2019;4 (14) [PubMed]
  • Donkers Joanne M. Targeting hepatic bile salt uptake to treat obesity-related metabolic disorders 2019. 175p. ISBN 9789461829733. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van de Graaf K. F. J. , Oude Elferink R. P. J.)


  • Adam Aziza A. A., van der Mark Vincent A., Donkers Joanne M., Wildenberg Manon E., Oude Elferink Ronald P. J., Chamuleau Robert A. F. M., Hoekstra Ruurdtje A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines PLoS ONE 2018;13 (4) [PubMed]


  • Slijepcevic Davor, Roscam Abbing Reinout L. P., Katafuchi Takeshi, Blank Antje, Donkers Joanne M., van Hoppe Stéphanie, de Waart Dirk R., Tolenaars Dagmar, van der Meer Jonathan H. M., Wildenberg Manon, Beuers Ulrich, Oude Elferink Ronald P. J., Schinkel Alfred H., van de Graaf Stan F. J. Hepatic Uptake of Conjugated Bile Acids Is Mediated by Both Sodium Taurocholate Cotransporting Polypeptide and Organic Anion Transporting Polypeptides and Modulated by Intestinal Sensing of Plasma Bile Acid Levels in Mice Hepatology (Baltimore, Md.) 2017;66 (5):1631-1643 [PubMed]
  • Donkers Joanne M., Zehnder Benno, van Westen Gerard J. P., Kwakkenbos Mark J., IJzerman Adriaan P., Oude Elferink Ronald P. J., Beuers Ulrich, Urban Stephan, van de Graaf Stan F. J. Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP Scientific reports 2017;7 (1):15307 [PubMed]
  • Kersseboom Simone, van Gucht Anja L. M., van Mullem Alies, Brigante Giulia, Farina Stefania, Carlsson Bo, Donkers Joanne M., van de Graaf Stan F. J., Peeters Robin P., Visser Theo J. Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome Endocrinology 2017;158 (10):3307-3318 [PubMed]