C.C. Paulusma PhD publications

2020

• Roscam Abbing Reinout L. P., Slijepcevic Davor, Donkers Joanne M., Havinga Rick, Duijst Suzanne, Paulusma Coen C., Kuiper Johan, Kuipers Folkert, Groen Albert K., Oude Elferink Ronald P. J., van de Graaf Stan F. J. Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice Hepatology (Baltimore, Md.) 2020;71 (1):247-258 [PubMed]
• Smith-Cortinez Natalia, Fagundes Raphael R., Gomez Valentina, Kong Defu, de Waart Dirk R., Heegsma Janette, Sydor Svenja, Olinga Peter, de Meijer Vincent E., Taylor Cormac T., Bank Ruud, Paulusma Coen C., Faber Klaas Nico Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition FASEB journal 2020 [PubMed]
• Roscam Abbing Reinout L. P., Kuipers Folkert, Paulusma Coen C., Verkade Henkjan J., Groen Albert K., Oude Elferink Ronald P. J., van de Graaf Stan F. J. REPLY: Hepatology (Baltimore, Md.) 2020;72 (5):1885-1886 [PubMed]

2019

• Saeed Ali, Yang Jing, Heegsma Janette, Groen Albert K., van Mil Saskia W. C., Paulusma Coen C., Zhou Lu, Wang Bangmao, Faber Klaas Nico Farnesoid X receptor and bile acids regulate vitamin A storage Scientific reports 2019;9 (1) [PubMed]
• Aronson Sem J., Bakker Robert S., Shi Xiaoxia, Duijst Suzanne, ten Bloemendaal Lysbeth, de Waart Dirk R., Verheij Joanne, Ronzitti Giuseppe, Oude Elferink Ronald P., Beuers Ulrich, Paulusma Coen C., Bosma Piter J. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice Journal of hepatology 2019;71 (1):153-162 [PubMed]
• Naik Jyoti, Hau Chi M., Bloemendaal Lysbeth ten, Mok Kam S., Hajji Najat, Wehman Ann M., Meisner Sander, Muncan Vanesa, Paauw Nanne J., de Vries H. E., Nieuwland Rienk, Paulusma Coen C., Bosma Piter J. The P4-ATPase ATP9A is a novel determinant of exosome release PLoS ONE 2019;14 (4) [PubMed]

2018

• Chang Jung-Chin Soluble adenylyl cyclase: A regulator of intrinsic cellular functions 2018. 259p. ISBN 9789402812961. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J., Verhoeven A. J.; Co-supervisor: Paulusma C. C.)

2017

• van der Mark Vincent A. ATP8B1 and cellular trafficking 2017. 175p. ISBN 9789491602986. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Paulusma C. C.)
• Vaz Frédéric M., Huidekoper Hidde H., Paulusma Coen C. Extended Abstract: Deficiency of Sodium Taurocholate Cotransporting Polypeptide (SLC10A1): A New Inborn Error of Metabolism with an Attenuated Phenotype Digestive diseases (Basel, Switzerland) 2017;35 (3):259-260 [PubMed]
• van der Mark Vincent A., Ghiboub Mohammed, Marsman Casper, Zhao Jing, van Dijk Remco, Hiralall Johan K., Ho-Mok Kam S., Castricum Zoë, de Jonge Wouter J., Oude Elferink Ronald P. J., Paulusma Coen C. Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 Cellular and molecular life sciences 2017;74 (4):715-730 [PubMed]
• van der Mark Vincent A., Ghiboub Mohammed, Marsman Casper, Zhao Jing, van Dijk Remco, Hiralall Johan K., Ho-Mok Kam S., Castricum Zoë, de Jonge Wouter J., Elferink Ronald P. J. Oude, Paulusma Coen C. Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 (vol 74, pg 715, 2017) Cellular and molecular life sciences 2017;74 (7):1365 [PubMed]
• Hanley Joanna, Dhar Dipok Kumar, Mazzacuva Francesca, Fiadeiro Rebeca, Burden Jemima J., Lyne Anne-Marie, Smith Holly, Straatman-Iwanowska Anna, Banushi Blerida, Virasami Alex, Mills Kevin, Lemaigre Frederic P., Knisely A. S., Howe Steven, Sebire Neil, Waddington Simon N., Paulusma Coen C., Clayton Peter, Gissen Paul Vps33b is crucial for structural and functional hepatocyte polarity Journal of hepatology 2017;66 (5):1001-1011 [PubMed]

2016

• de Waart Dirk R., Naik Jyoti, Utsunomiya Karina S., Duijst Suzanne, Ho-Mok Kam, Bolier A. Ruth, Hiralall Johan, Bull Laura N., Bosma Piter J., Oude Elferink Ronald P. J., Paulusma Coen C. ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes Hepatology (Baltimore, Md.) 2016;64 (1):161-174 [PubMed]
• van der Woerd Wendy L., Wichers Catharina G. K., Vestergaard Anna L., Andersen Jens Peter, Paulusma Coen C., Houwen Roderick H. J., van de Graaf Stan F. J. Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis Journal of hepatology 2016;64 (6):1339-1347 [PubMed]
• Lionarons Daniël A., Heger Michal, van Golen Rowan F., Alles Lindy K., van der Mark Vincent A., Kloek Jaap J., de Waart Dirk R., Marsman Hendrik A., Rusch Henny, Verheij Joanne, Beuers Ulrich, Paulusma Coen C., van Gulik Thomas M. Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport Scientific reports 2016;6:31829 [PubMed]
• Chang Jung-Chin, Go Simei, de Waart Dirk R., Munoz-Garrido Patricia, Beuers Ulrich, Paulusma Coen C., Oude Elferink Ronald Soluble Adenylyl Cyclase Regulates Bile Salt-Induced Apoptosis in Human Cholangiocytes Hepatology (Baltimore, Md.) 2016;64 (2):522-534 [PubMed]
• van der Mark Vincent A., de Jonge Hugo R., Chang Jung-Chin, Ho-Mok Kam S., Duijst Suzanne, Vidović Dragana, Carlon Marianne S., Oude Elferink Ronald P. J., Paulusma Coen C. The phospholipid flippase ATP8B1 mediates apical localization of the cystic fibrosis transmembrane regulator BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2016;1863 (9):2280-2288 [PubMed]

2015

• Naik Jyoti, de Waart Dirk R., Utsunomiya Karina, Duijst Suzanne, Mok Kam Ho, Oude Elferink Ronald P. J., Bosma Piter J., Paulusma Coen C. ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function Digestive diseases (Basel, Switzerland) 2015;33 (3):314-318 [PubMed]
• Bruurs Lucas J. M., Donker Lisa, Zwakenberg Susan, Zwartkruis Fried J., Begthel Harry, Knisely A. S., Posthuma George, van de Graaf Stan F. J., Paulusma Coen C., Bos Johannes L. ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization Journal of cell biology 2015;210 (7):1055-1063 [PubMed]
• Ansari Israr-Ul H., Longacre Melissa J., Paulusma Coen C., Stoker Scott W., Kendrick Mindy A., MacDonald Michael J. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION Journal of biological chemistry 2015;290 (38):23110-23123 [PubMed]
• Elferink Ronald P. J. Oude, Paulusma Coen C. MRP2 in cholestasis: Putting down the anchor Journal of hepatology 2015;63 (6):1309-1310 [PubMed]
• Vaz Frédéric M., Paulusma Coen C., Huidekoper Hidde, de Ru Minke, Lim Cynthia, Koster Janet, Ho-Mok Kam, Bootsma Albert H., Groen Albert K., Schaap Frank G., Oude Elferink Ronald P. J., Waterham Hans R., Wanders Ronald J. A. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype Hepatology (Baltimore, Md.) 2015;61 (1):260-267 [PubMed]

2014

• Kunne Cindy, Acco Alexandra, Duijst Suzanne, de Waart Dirk R., Paulusma Coen C., Gaemers Ingrid, Oude Elferink Ronald P. J. FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (5):739-746 [PubMed]
• Kunne Cindy, de Graaff Marijke, Duijst Suzanne, de Waart Dirk R., Oude Elferink Ronald P. J., Paulusma Coen C. Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis Laboratory investigation; a journal of technical methods and pathology 2014;94 (10):1103-1113 [PubMed]
• van der Mark Vincent A., de Waart D. Rudi, Ho-Mok Kam S., Tabbers Merit M., Voogt Heleen W., Oude Elferink Ronald P. J., Knisely A. S., Paulusma Coen C. The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2014;1842 (12 Part A):2378-2386 [PubMed]

2013

• Kunne Cindy Mouse models of cholestatic liver disease. pfic reviisited 2013. 153p. ISBN 9789461823489. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Paulusma C. C.)
• van der Mark Vincent A., Oude Elferink Ronald P. J., Paulusma Coen C. P4 ATPases: Flippases in Health and Disease International journal of molecular sciences 2013;14 (4):7897-7922 [PubMed]

2012

• Hohenester Simon, Wenniger Lucas Maillette de Buy, Paulusma Coen C., van Vliet Sandra J., Jefferson Douglas M., Elferink Ronald P. Oude, Beuers Ulrich A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes Hepatology (Baltimore, Md.) 2012;55 (1):173-183 [PubMed]
• Folmer Dineke E., Mok Kam S., de Wee Sebastiaan W., Duijst Suzanne, Hiralall Johan K., Seppen Jurgen, Oude Elferink Ronald P. J., Paulusma Coen C. Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated beta-subunit for P4 ATPases journal of histochemistry and cytochemistry 2012;60 (3):205-218 [PubMed]
• de Waart Dirk R., van de Wetering Koen, Kunne Cindy, Duijst Suzanne, Paulusma Coen C., Oude Elferink Ronald P. J. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4 Drug metabolism and disposition: the biological fate of chemicals 2012;40 (3):515-521 [PubMed]

2011

• Oude Elferink Ronald P. J., Paulusma C. C. ABCG5/8 and its Role in Sterol Homeostasisin: Kenneth J. Linton, B. Holland, editors. The ABC Transportersof Human Physiology and Disease. Singapore: World Scientific; 2011. p. 375-397, ISBN 3978981428006
• de Waart Dirk Rudi Basolateral and apical ABC transporters in liver and intestineAmsterdam: Ipskamp; 2011. 200p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink Ronald P. J.; Co-supervisor: Paulusma C. C.)
• Groen Annemiek, Romero Marta Rodriguez, Kunne Cindy, Hoosdally Sarah J., Dixon Peter H., Wooding Carol, Williamson Catherine, Seppen Jurgen, van den Oever Karin, Mok Kam S., Paulusma Coen C., Linton Kenneth J., Oude Elferink Ronald P. J. Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity Gastroenterology 2011;141 (5):1927-37.e1-4 [PubMed]
• Paulusma Coen C., Houwen Roderick H. J., Williamson Patrick L. The flip side of cardiolipin import Nature medicine 2011;17 (4):413 [PubMed]

2010

• Paulusma Coen C., Oude Elferink Ronald P. J. P4 ATPases - The physiological relevance of lipid flipping transporters FEBS letters 2010;584 (13):2708-2716 [PubMed]
• Paulusma Coen C., Oude Elferink Ronald P. J., Jansen Peter L. M. Progressive Familial Intrahepatic Cholestasis Type 1 Seminars in liver disease 2010;30 (2):117-124 [PubMed]
• Shah Sohela, Sanford Ukina R., Vargas Julie C., Xu Hongmei, Groen Annamiek, Paulusma Coen C., Grenert James P., Pawlikowska Ludmila, Sen Saunak, Elferink Ronald P. J. Oude, Bull Laura N. Strain background modifies phenotypes in the ATP8B1-deficient mouse PLoS ONE 2010;5 (2):e8984 [PubMed]

2009

• Paulusma Coen C., Dewaart D. Rudi, Kunne Cindy, Mok Kam S., Oude Elferink Ronald P. J. Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content Journal of biological chemistry 2009;284 (15):9947-9954 [PubMed]
• Folmer Dineke E., van der Mark Vincent A., Ho-Mok Kam S., Oude Elferink Ronald P. J., Paulusma Coen C. Differential Effects of Progressive Familial Intrahepatic Cholestasis Type 1 and Benign Recurrent Intrahepatic Cholestasis Type 1 Mutations on Canalicular Localization of ATP8B1 Hepatology (Baltimore, Md.) 2009;50 (5):1597-1605 [PubMed]
• Folmer Dineke E., Elferink Ronald P. J. Oude, Paulusma Coen C. P4 ATPases - lipid flippases and their role in disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2009;1791 (7):628-635 [PubMed]
• Elferink Ronald P.J.Oude, Paulusma Coen C. The Function of the Canalicular Membrane in Bile Formation and Secretionin: The Liver. John Wiley & Sons, Ltd.; 2009. p. 339-348, ISBN 9780470723135
• Groen Annemiek The molecular mechanis of Atp8b1 - deficiency 2009. 158p. ISBN 9789090239651. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Oude Elferink R. P. J.; Co-supervisor: Paulusma C. C.)
• Elferink R. O., De Waart R., Kunne C., Paulusma C. The role of ABC transporters in drug absorption and enterohepatic circulation Journal of Veterinary Pharmacology and Therapeutics 2009;32 (SUPPL. 1):56

2008

• Groen Annemiek, Kunne Cindy, Jongsma Geartsje, van den Oever Karin, Mok Kam S., Petruzzelli Michele, Vrins Carlos L. J., Bull Laura, Paulusma Coen C., Oude Elferink Ronald P. J. Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice Gastroenterology 2008;134 (7):2091-2100 [PubMed]
• van Til Niek P., Heutinck Kirstin M., van der Rijt Roos, Paulusma Coen C., van Wijland Michel, Markusic David M., Elferink Ronald P. J. Oude, Seppen Jurgen Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity Retrovirology 2008;5:14 [PubMed]
• Paulusma Coen C., Folmer Dineke E., Ho-Mok Kam S., de Waart D. Rudi, Hilarius Petra M., Verhoeven Arthur J., Oude Elferink Ronald P. J. ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity Hepatology (Baltimore, Md.) 2008;47 (1):268-278 [PubMed]

2007

• Oude Elferink Ronald P. J., Paulusma Coen C. Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein) Pflugers Archiv 2007;453 (5):601-610 [PubMed]
• Groen Annemiek, Kunne Cindy, Paulusma Coen C., Kramer Werner, Agellon Luis B., Bull Laura N., Elferink Ronald P. J. Oude Intestinal bile salt absorption in Atp8b1 deficient mice Journal of hepatology 2007;47 (1):114-122 [PubMed]

2006

• Paulusma Coen C., Groen Annemiek, Kunne Cindy, Ho-Mok Kam S., Spijkerboer Astrid L., Rudi de Waart D., Hoek Frans J., Vreeling Heleen, Hoeben Kees A., van Marle Jan, Pawlikowska Ludmila, Bull Laura N., Hofmann Alan F., Knisely A. S., Oude Elferink Ronald P. J. Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport Hepatology (Baltimore, Md.) 2006;44 (1):195-204 [PubMed]
• Paulusma Coen C., Oude Elferink Ronald P. J. Diseases of intramembranous lipid transport FEBS letters 2006;580 (23):5500-5509 [PubMed]
• Oude Elferink Ronald P. J., Paulusma Coen C., Groen Albert K. Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases Gastroenterology 2006;130 (3):908-925 [PubMed]
• de Waart Dirk R., Paulusma Coen C., Kunne Cindy, Oude Elferink Ronald P. J. Multidrug resistance associated protein 2 mediates transport of prostaglandin E2 Liver international 2006;26 (3):362-368 [PubMed]

2005

• van Veelen Lieneke R., Essers Jeroen, van de Rakt Mandy W. M. M., Odijk Hanny, Pastink Albert, Zdzienicka Małgorzata Z., Paulusma Coen C., Kanaar Roland Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52 Mutation research 2005;574 (1-2):34-49 [PubMed]
• Paulusma C. C., Oude Elferink R. P. J. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2005;1741 (1-2):11-24 [PubMed]

2003

• Paulusma C. C. Linking architecture to infrastructure Journal of hepatology 2003;38 (4):551-553

2002

• Essers Jeroen, Houtsmuller Adriaan B., van Veelen Lieneke, Paulusma Coen, Nigg Alex L., Pastink Albert, Vermeulen Wim, Hoeijmakers Jan H. J., Kanaar Roland Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage EMBO journal 2002;21 (8):2030-2037 [PubMed]

2001

• Ristic D., Wyman C., Paulusma C., Kanaar R. The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA Proceedings of the National Academy of Sciences of the United States of America 2001;98 (15):8454-8460 [PubMed]

2000

• Bernard P. H., Blanc J. F., Paulusma C., Le Bail B., Carles J., Balabaud C., Bioulac-Sage P. Multiple black hepatocellular adenomas in a male patient European journal of gastroenterology & hepatology 2000;12 (11):1253-1257 [PubMed]
• Paulusma C. C., Kothe M. J., Bakker C. T., Bosma P. J., van Bokhoven I., van Marle J., Bolder U., Tytgat G. N., Oude Elferink R. P. Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver Hepatology (Baltimore, Md.) 2000;31 (3):684-693 [PubMed]

1999

• Paulusma C. C., van Geer M. A., Evers R., Heijn M., Ottenhoff R., Borst P., Oude Elferink R. P. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione Biochemical journal 1999;338 ( Pt 2):393-401 [PubMed]

1998

• Evers R., Kool M., van Deemter L., Janssen H., Calafat J., Oomen L. C., Paulusma C. C., Oude Elferink R. P., Baas F., Schinkel A. H., Borst P. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA Journal of clinical investigation 1998;101 (7):1310-1319 [PubMed]

1997

• Paulusma C. C., Kool M., Bosma P. J., Scheffer G. L., ter Borg F., Scheper R. J., Tytgat G. N., Borst P., Baas F., Oude Elferink R. P. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome Hepatology (Baltimore, Md.) 1997;25 (6):1539-1542 [PubMed]
• Paulusma C. C., Oude Elferink R. P. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man Journal of molecular medicine (Berlin, Germany) 1997;75 (6):420-428 [PubMed]

1996

• Paulusma C. C., Bosma P. J., Zaman G. J., Bakker C. T., Otter M., Scheffer G. L., Scheper R. J., Borst P., Oude Elferink R. P. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene Science 1996;271 (5252):1126-1128 [PubMed]
• Oude Elferink R. P., Frijters C. M., Paulusma C., Groen A. K. Regulation of canalicular transport activities Journal of hepatology 1996;24 (Suppl. 1):94-99 [PubMed]

1995

• Zaman G. J., Lankelma J., van Tellingen O., Beijnen J., Dekker H., Paulusma C., Oude Elferink R. P., Baas F., Borst P. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein Proceedings of the National Academy of Sciences of the United States of America 1995;92 (17):7690-7694 [PubMed]

1994

• Paulusma C. C., van der Kruijssen C. M., van den Eijnden-van Raaij A. J. Localization of activin subunits in early murine development determined by subunit-specific antibodies Journal of immunological methods 1994;169 (2):143-152 [PubMed]