PhD G.B. Afink publications

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Publications PhD G.B. Afink

Position
Research Associate
Main activities
Research
Specialisation
Molecular Biology
Focus of research

About 25% of all pregnancies are complicated by gestational disease, of which severe hypertension (i.e. early preeclampsia and HELLP syndrome) and preterm labour are the leading cause of pregnancy-related maternal morbidity and mortality and poor neonatal outcome. Although there is consensus that the causal organ for these gestational diseases is the placenta the underlying multifactorial molecular causes and early and reliable clinical biomarkers that explain and predict development of obstetrical disease during the course of pregnancy are not available.

2020

  • Amraoui Fouad, Hassani Lahsinoui Hajar, Spijkers Leon J. A., Vogt Liffert, Peters Stephan L. M., Wijesinghe Dayanjan S., Warncke Urszula O., Chalfant Charles E., Ris-Stalpers Carrie, van den Born Bert-Jan H., Afink Gijs B. Plasma ceramide is increased and associated with proteinuria in women with pre-eclampsia and HELLP syndrome Pregnancy hypertension 2020;19:100-105 [PubMed]

2019

  • Georgiadou Danai, Boussata Souad, Ranzijn Willemijn H. M., Root Leah E. A., Hillenius Sanne, bij de Weg Jeske M., Abheiden Carolien N. H., de Boer Marjon A., de Vries Johanna I. P., Vrijkotte Tanja G. M., Lambalk Cornelis B., Kuijper Esther A. M., Afink Gijs B., van Dijk Marie Peptide hormone ELABELA enhances extravillous trophoblast differentiation, but placenta is not the major source of circulating ELABELA in pregnancy Scientific reports 2019;9 (1) [PubMed]
  • Lawera Aleksandra, Tong Zhen, Thorikay Midory, Redgrave Rachael E., Cai Jie, van Dinther Maarten, Morrell Nicholas W., Afink Gijs B., Charnock-Jones D. Stephen, Arthur Helen M., Dijke Peter Ten, Li Wei Role of soluble endoglin in BMP9 signaling Proceedings of the National Academy of Sciences of the United States of America 2019;116 (36):17800-17808 [PubMed]
  • Georgiadou Danai, Afink Gijs B., van Dijk Marie The apelinergic-axis in human preeclamptic pregnancies: A systematic review Pregnancy hypertension 2019;17:148-157 [PubMed]

2018

  • Petry Clive J., Ong Ken K., Burling Keith A., Barker Peter, Goodburn Sandra F., Perry John R. B., Acerini Carlo L., Hughes Ieuan A., Painter Rebecca C., Afink Gijs B., Dunger David B., O'rahilly Stephen Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study [version 1; referees: 3 approved] Wellcome Open Research 2018;3 [PubMed]
  • Fernando Febilla, Boussata Souad, Jongejan Aldo, van der Post Joris A., Afink Gijs, Ris-Stalpers Carrie In silico analysis of the Mus musculus uterine gene expression landscape during pregnancy identifies putative upstream regulators for labour PLoS ONE 2018;13 (9) [PubMed]

2017

  • Ho Lena, van Dijk Marie, Chye Sam Tan Jian, Messerschmidt Daniel M., Chng Serene C., Ong Sheena, Yi Ling Ka, Boussata Souad, Goh Grace Hui-Yi, Afink Gijs B., Lim Chin Yan, Dunn N. Ray, Solter Davor, Knowles Barbara B., Reversade Bruno ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice Science 2017;357 (6352):707-713 [PubMed]

2016

  • Prins J. R., van der Hoorn M. L. P., Keijser R., Ris-Stalpers C., van Beelen E., Afink G. B., Claas F. H. J., van der Post J. A. M., Scherjon S. A. Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia Human immunology 2016;77 (1):68-70 [PubMed]

2015

  • Jebbink J. M., Boot R. G., Keijser R., Moerland P. D., Aten J., Veenboer G. J. M., van Wely M., Buimer M., Ver Loren van Themaat E., Aerts J. M. F. G., van der Post J. A. M., Afink G. B., Ris-Stalpers C. Increased glucocerebrosidase expression and activity in preeclamptic placenta Placenta 2015;36 (2):160-169 [PubMed]
  • van Uitert Miranda, Moerland Perry D., Enquobahrie Daniel A., Laivuori Hannele, van der Post Joris A. M., Ris-Stalpers Carrie, Afink Gijs B. Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia PLoS ONE 2015;10 (7):e0132468 [PubMed]
  • Vissenberg R., Manders V. D., Mastenbroek S., Fliers E., Afink G. B., Ris-Stalpers C., Goddijn M., Bisschop P. H. Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction Human reproduction update 2015;21 (3):378-387 [PubMed]
  • Amraoui F., Hassani Lahsinoui H., Boussata S., Keijser R., Veenboer G. J. M., Middeldorp S., van der Post J. A. M., Ris-Stalpers C., Afink G. B., van den Born B. J. H. Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in normotensive and pre-eclamptic pregnancies Placenta 2015;36 (11):1218-1224 [PubMed]
  • Fernando Febilla, Keijser Remco, Henneman Peter, van der Kevie-Kersemaekers Anne-Marie F., Mannens Marcel Mam, van der Post Joris Am, Afink Gijs B., Ris-Stalpers Carrie The idiopathic preterm delivery methylation profile in umbilical cord blood DNA BMC genomics 2015;16 (1):736 [PubMed]
  • Jebbink Jiska, Veenboer Geertruda, Boussata Souad, Keijser Remco, Kremer Andreas E., Elferink Ronald Oude, van der Post Joris, Afink Gijs, Ris-Stalpers Carrie Total bile acids in the maternal and fetal compartment in relation to placental ABCG2 expression in preeclamptic pregnancies complicated by HELLP syndrome BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2015;1852 (1):131-136 [PubMed]

2014

  • Jebbink Jiska, Tabbers Merit, Afink Gijs, Beuers Ulrich, Oude Elferink Ronald, Ris-Stalpers Carrie, van der Post Joris HELLP syndrome preceded by intrahepatic cholestasis of pregnancy: one serious itch BMJ case reports 2014;2014:bcr2013203208 [PubMed]
  • Jebbink Jiska Maren Preeclamptic disorders of pregnancy; Novel molecular insights 2014. 159p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van der Post J. A. M.; Co-supervisors: Afink G. B., Ris-Stalpers C.)
  • Karamat Fares A., Oudman Inge, Ris-Stalpers Carrie, Afink Gijs B., Keijser Remco, Clark Joseph F., van Montfrans Gert A., Brewster Lizzy M. Resistance artery creatine kinase mRNA and blood pressure in humans Hypertension 2014;63 (1):68-73 [PubMed]
  • Amraoui Fouad, Spijkers Léon, Hassani Lahsinoui Hajar, Vogt Liffert, van der Post Joris, Peters Stephan, Afink Gijs, Ris-Stalpers Carrie, van den Born Bert-Jan SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice PLoS ONE 2014;9 (3):e91897 [PubMed]

2013

  • Böing A. N., Stap J., Hau C. M., Afink G. B., Ris-Stalpers C., Reits E. A., Sturk A., van Noorden C. J. F., Nieuwland R. Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2013;1833 (8):1844-1852 [PubMed]
  • Kleinrouweler C. Emily, van Uitert Miranda, Moerland Perry D., Ris-Stalpers Carrie, van der Post Joris A. M., Afink Gijs B. Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis PLoS ONE 2013;8 (7):e68991 [PubMed]
  • de Laat Monique W. M., Pieper Petronella G., Oudijk Martijn A., Mulder Barbara J. M., Christoffels Vincent M., Afink Gijs B., Postma Alex V., Ris-Stalpers Carrie The clinical and molecular relations between idiopathic preterm labor and maternal congenital heart defects Reproductive sciences (Thousand Oaks, Calif.) 2013;20 (2):190-201 [PubMed]

2012

  • Burniat Agnès, Pirson Isabelle, Vilain Catheline, Kulik Willem, Afink Gijs, Moreno-Reyes Rodrigo, Corvilain Bernard, Abramowicz Marc Iodotyrosine Deiodinase Defect Identified via Genome-Wide Approach Journal of clinical endocrinology and metabolism 2012;97 (7):E1276-E1283 [PubMed]
  • Jebbink Jiska, Wolters Astrid, Fernando Febilla, Afink Gijs, van der Post Joris, Ris-Stalpers Carrie Molecular genetics of preeclampsia and HELLP syndrome - A review BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2012;1822 (12):1960-1969 [PubMed]
  • Liu Zhen, Afink Gijs B., ten Dijke Peter Soluble fms-like tyrosine kinase 1 and soluble endoglin are elevated circulating anti-angiogenic factors in pre-eclampsia Pregnancy hypertension 2012;2 (4):358-367
  • van den Akker Jeroen, van Weert Angela, Afink Gijs, Bakker Erik N. T. P., van der Pol Edwin, Böing Anita N., Nieuwland Rienk, VanBavel Ed Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation Amino acids 2012;42 (2-3):961-973 [PubMed]

2011

  • Nazarenko Inga, Hedrén Anna, Sjödin Hanna, Orrego Abiel, Andrae Johanna, Afink Gijs B., Nistér Monica, Lindström Mikael S. Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells PLoS ONE 2011;6 (4):e18303 [PubMed]
  • Jebbink Jiska, Keijser Remco, Veenboer Geertruda, van der Post Joris, Ris-Stalpers Carrie, Afink Gijs Expression of Placental FLT1 Transcript Variants Relates to Both Gestational Hypertensive Disease and Fetal Growth Hypertension 2011;58 (1):70-U129 [PubMed]
  • Nazarenko Inga Modeling PDGF-driven gliomagenesis in the mouse 2011. ISBN 9789174574517. [UvA Dissertations Online] Karolinska Institute, Stockholm, Sweden: Oncology-Pathology. (Supervisor: Nistér M.; Co-supervisors: Lindström Mikael S., Afink Gijs B.)

2010

  • Afink Gijs B., Veenboer Geertruda, de Randamie Janine, Keijser Remco, Meischl Christof, Niessen Hans, Ris-Stalpers Carrie Initial Characterization of C16orf89, A Novel Thyroid-Specific Gene Thyroid 2010;20 (7):811-821 [PubMed]

2009

  • Hede Sanna-Maria, Hansson Inga, Afink Gijs B., Eriksson Anna, Nazarenko Inga, Andrae Johanna, Genove Guillem, Westermark Bengt, Nistér Monica GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background Glia 2009;57 (11):1143-1153 [PubMed]

2008

  • Toepoel Mascha, Joosten Paul H. L. J., Knobbe Christiane B., Afink Gijs B., Zotz Rainer B., Steegers-Theunissen Regine P. M., Reifenberger Guido, van Zoelen Everardus J. J. Haplotype-specific expression of the human PDGFRA gene correlates with the risk of glioblastomas International journal of cancer. Journal international du cancer 2008;123 (2):322-329 [PubMed]
  • Afink Gijs, Kulik Willem, Overmars Henk, de Randamie Janine, Veenboer Truus, van Cruchten Arno, Craen Margarita, Ris-Stalpers Carrie Molecular characterization of iodotyrosine dehalogenase deficiency in patients with hypothyroidism Journal of clinical endocrinology and metabolism 2008;93 (12):4894-4901 [PubMed]

2005

  • de Bustos C., Smits A., Strömberg B., Collins V. P., Nistér M., Afink G. A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas Journal of medical genetics 2005;42 (1):31-37 [PubMed]
  • Zhang Xiao-Qun, Afink Gijs B., Hu Xin-Rong, Forsberg-Nilsson Karin, Nistér Monica Gli1 is not required for Pdgfralpha expression during mouse embryonic development Differentiation; research in biological diversity 2005;73 (2-3):109-119 [PubMed]

2004

  • Afink Gijs, Westermark Ulrica K., Lammerts Ellen, Nistér Monica C/EBP is an essential component of PDGFRA transcription in MG-63 cells Biochemical and biophysical research communications 2004;315 (2):313-318 [PubMed]
  • Andrae Johanna, Afink Gijs, Zhang Xiao-Qun, Wurst Wolfgang, Nistér Monica Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia Molecular and cellular neurosciences 2004;26 (2):308-321 [PubMed]

2002

  • Joosten Paul H. L. J., Toepoel Mascha, van Oosterhout Dirk, Afink Gijs B., van Zoelen Everardus J. J. A regulating element essential for PDGFRA transcription is recognized by neural tube defect-associated PRX homeobox transcription factors BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2002;1588 (3):254-260 [PubMed]

2001

  • Hu X., Pang T., Guo Z., Pontén J., Nistér M., Afink G. Bernard Oncogene lineages of human papillomavirus type 16 E6, E7 and E5 in preinvasive and invasive cervical squamous cell carcinoma Journal of pathology 2001;195 (3):307-311 [PubMed]
  • Ling G., Ahmadian A., Persson A., Undén A. B., Afink G., Williams C., Uhlén M., Toftgård R., Lundeberg J., Pontén F. PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer Oncogene 2001;20 (53):7770-7778 [PubMed]
  • Andrae J., Hansson I., Afink G. B., Nistér M. Platelet-derived growth factor receptor-alpha in ventricular zone cells and in developing neurons Molecular and cellular neurosciences 2001;17 (6):1001-1013 [PubMed]

2000

  • A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth Development (Cambridge, England) 2000;127 (21):4519-4529 [PubMed]
  • Comparison of chromosome 3p deletions between cervical precancers synchronous with and without invasive cancer International journal of cancer. Journal international du cancer 2000;86 (4):518-523 [PubMed]
  • Immunohistochemical and DNA sequencing analysis on human mismatch repair gene MLH1 in cervical squamous cell carcinoma with LOH of this gene Anticancer research 2000;20 (1A):171-175 [PubMed]

1998

  • Altered regulation of platelet-derived growth factor receptor-alpha gene-transcription in vitro by spina bifida-associated mutant Pax1 proteins Proceedings of the National Academy of Sciences of the United States of America 1998;95 (24):14459-14463 [PubMed]
  • Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter/lacZ transgene Mechanisms of development 1998;70 (1-2):167-180 [PubMed]

1995

  • Molecular cloning and functional characterization of the human platelet-derived growth factor alpha receptor gene promoter Oncogene 1995;10 (8):1667-1672 [PubMed]

1994

  • Bradykinin-induced growth inhibition of normal rat kidney (NRK) cells is paralleled by a decrease in epidermal-growth-factor receptor expression Biochemical journal 1994;298 ( Pt 2):335-340 [PubMed]
  • Effect of bradykinin on loss of density-dependent growth inhibition of normal rat kidney cells Cellular and molecular biology (Noisy-le-Grand, France) 1994;40 (5):717-721 [PubMed]
  • Lysophosphatidic acid and bradykinin have opposite effects on phenotypic transformation of normal rat kidney cells Journal of cellular biochemistry 1994;56 (4):480-489 [PubMed]

1991

  • Colonic Cl channel blockade by three classes of compounds American journal of physiology 1991;261 (1 Part 1):C51-C63 [PubMed]