PhD J.E.J. Guikema publications

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Publications PhD J.E.J. Guikema

Position
Research Associate
Main activities
Research
Specialisation
Molecular biology of immunoglobulin gene recombinations
Focus of research

Our research is focused on the role of DNA mutagenic processes in the adaptive immune system and in B-cell malignancies. I have a background in molecular biology and immunology, and my research includes DNA repair, immunoglobulin gene diversification mechanisms and signaling in B cells and B-cell malignancies. My laboratory addresses fundamental questions on DNA damage and repair in B cells and lymphomas, and performs translational research on novel drugs and therapeutic targets for (childhood) leukemia and multiple myeloma. My laboratory is part of the Lymphoma and Myeloma Center Amsterdam (LYMMCARE) consortium.

2019

  • Slot L. M., Wormhoudt T. A. M., Kwakkenbos M. J., Wagner K., Ballering A., Jongejan A., van Kampen A. C. M., Guikema J. E. J., Bende R. J., van Noesel C. J. M. De novo gene mutations in normal human memory B cells Leukemia 2019;33 (5):1219-1230 [PubMed]
  • Leeksma Alexander Ch. Making sense of genomic complexity and nonsense-RNA in hematologic malignancies 2019. 194p. ISBN 9789463753432. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Eldering E. E. , Kater A. P.; Co-supervisor: Guikema J. E. J.)
  • Bahjat Mahnoush The delicate balance between DNA damage and repair in B cells 2019. 178p. ISBN 9789463753296. [UvA Dissertations Online] University of Amsterdam. (Supervisor: van Noesel C. J. M.; Co-supervisor: Guikema J. E. J.)
  • Bahjat Mahnoush, de Wilde Guus, van Dam Tijmen, Maas Chiel, Bloedjes Timon, Bende Richard J, van Noesel Carel J M, Luijks Dieuwertje M, Eldering Eric, Kersten Marie José, Guikema Jeroen E J The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors Cell cycle (Georgetown, Tex.) 2019;18 (18):2307-2322 [PubMed]

2017

  • van Andel Harmen, Ren Zemin, Koopmans Iris, Joosten Sander P. J., Kocemba Kinga A., de Lau Wim, Kersten Marie José, de Bruin Alexander M., Guikema Jeroen E. J., Clevers Hans, Spaargaren Marcel, Pals Steven T. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins Proceedings of the National Academy of Sciences of the United States of America 2017;114 (2):376-381 [PubMed]
  • Reshetova Polina, van Schaik Barbera D. C., Klarenbeek Paul L., Doorenspleet Marieke E., Esveldt Rebecca E. E., Tak Paul-Peter, Guikema Jeroen E. J., de Vries Niek, van Kampen Antoine H. C. Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing Frontiers in immunology 2017;8:221 [PubMed]
  • Bahjat Mahnoush, Bloedjes Timon A., van der Veen Amélie, de Wilde Guus, Maas Chiel, Guikema Jeroen E. J. Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay Journal of visualized experiments 2017;2017 (124):e55703 [PubMed]
  • Guikema Jeroen E., Amiot Martine, Eldering Eric Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer Expert opinion on therapeutic targets 2017;21 (8):767-779 [PubMed]
  • Bahjat Mahnoush, Guikema Jeroen E. J. The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes International journal of molecular sciences 2017;18 (9):1876 [PubMed]
  • Dzikiewicz-Krawczyk A., Kok K., Slezak-Prochazka I., Robertus J.-L., Bruining J., Tayari M. M., Rutgers B., de Jong D., Koerts J., Seitz A., Li J., Tillema B., Guikema J. E., Nolte I. M., Diepstra A., Visser L., Kluiver J., van den Berg A. ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma Leukemia 2017;31 (6):1470-1473 [PubMed]

2016

  • Slot Linda M., Hoogeboom Robbert, Smit Laura A., Wormhoudt Thera A. M., Biemond Bart J., Oud Monique E. C. M., Schilder-Tol Esther J. M., Mulder André B., Jongejan Aldo, van Kampen Antoine H. C., Kluin Philip M., Guikema Jeroen E. J., Bende Richard J., van Noesel Carel J. M. B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains American journal of pathology 2016;186 (12):3273-3284 [PubMed]
  • Slinger Erik, Wensveen Felix M., Guikema Jeroen E., Kater Arnon P., Eldering Eric Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA Haematologica 2016;101 (9):e374-e377 [PubMed]
  • Bende Richard J., Janssen Jerry, Wormhoudt Thera A. M., Wagner Koen, Guikema Jeroen E. J., van Noesel Carel J. M. Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity Haematologica 2016;101 (5):e200-e203 [PubMed]
  • Ochodnicka-Mackovicova Katarina, Bahjat Mahnoush, Maas Chiel, van der Veen Amélie, Bloedjes Timon A., de Bruin Alexander M., van Andel Harmen, Schrader Carol E., Hendriks Rudi W., Verhoeyen Els, Bende Richard J., van Noesel Carel J. M., Guikema Jeroen E. J. The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling Journal of immunology (Baltimore, Md. 2016;197 (7):2918-2929 [PubMed]

2015

  • Hoogeboom R., Reinten R. J. A., Schot J.-J., Guikema J. E. J., Bende R. J., van Noesel C. J. M. In vitro induction of antibody secretion of primary B-cell chronic lymphocytic leukaemia cells Leukemia 2015;29 (1):244-247 [PubMed]
  • Kersten Marie José, Guikema Jeroen E. J. MYC in diffuse large B-cell lymphoma: always the bad guy? Leukemia & lymphoma 2015;56 (11):3003-3004 [PubMed]
  • Ochodnicka-Mackovicova Katarina, Bahjat Mahnoush, Bloedjes Timon A., Maas Chiel, de Bruin Alexander M., Bende Richard J., van Noesel Carel J. M., Guikema Jeroen E. J. NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity Blood 2015;126 (11):1324-1335 [PubMed]
  • Bende Richard J., Slot Linda M., Hoogeboom Robbert, Wormhoudt Thera A. M., Adeoye Akanbi O., Guikema Jeroen E. J., van Noesel Carel J. M. Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome Arthritis & rheumatology (Hoboken, N.J.) 2015;67 (4):1074-1083 [PubMed]

2014

  • Guikema Jeroen E. J., Linehan Erin K., Esa Nada, Tsuchimoto Daisuke, Nakabeppu Yusaku, Woodland Robert T., Schrader Carol E. Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells Journal of immunology (Baltimore, Md. 2014;193 (2):931-939 [PubMed]
  • Khair Lyne, Guikema Jeroen E. J., Linehan Erin K., Ucher Anna J., Leus Niek G. J., Ogilvie Colin, Lou Zhenkun, Schrader Carol E., Stavnezer Janet ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination Journal of immunology (Baltimore, Md. 2014;192 (10):4887-4896 [PubMed]

2013

  • Hoogeboom Robbert, van Kessel Kok P. M., Hochstenbach Frans, Wormhoudt Thera A., Reinten Roy J. A., Wagner Koen, Kater Arnon P., Guikema Jeroen E. J., Bende Richard J., van Noesel Carel J. M. A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi Journal of experimental medicine 2013;210 (1):59-70 [PubMed]
  • Hoogeboom R., Wormhoudt T. A., Schipperus M. R., Langerak A. W., Dunn-Walters D. K., Guikema J. E. J., Bende R. J., van Noesel C. J. M. A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient Leukemia 2013;27 (3):738-740 [PubMed]
  • Lascano Valeria, Guadagnoli Marco, Schot Jan G., Luijks Dieuwertje M., Guikema Jeroen E. J., Cameron Katherine, Hahne Michael, Pals Steven, Slinger Erik, Kipps Thomas J., van Oers Marinus H. J., Eldering Eric, Medema Jan Paul, Kater Arnon P. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model Blood 2013;122 (24):3960-3963 [PubMed]

2011

  • Staszewski Ori, Baker Richard E., Ucher Anna J., Martier Raygene, Stavnezer Janet, Guikema Jeroen E. J. Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells Molecular cell 2011;41 (2):232-242 [PubMed]
  • Pei De-Sheng, Yang Xiao-Jie, Liu Wei, Guikema Jeroen E. J., Schrader Carol E., Strauss Phyllis R. A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta Nucleic acids research 2011;39 (8):3156-3165 [PubMed]
  • Guikema Jeroen E. J., Gerstein Rachel M., Linehan Erin K., Cloherty Erin K., Evan-Browning Eric, Tsuchimoto Daisuke, Nakabeppu Yusaku, Schrader Carol E. Apurinic/Apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge Journal of immunology (Baltimore, Md. 2011;186 (4):1943-1950 [PubMed]

2010

  • Guikema Jeroen E. J., Schrader Carol E., Brodsky Michael H., Linehan Erin K., Richards Adam, El Falaky Nahla, Li Daniel H., Sluss Hayla K., Szomolanyi-Tsuda Eva, Stavnezer Janet p53 represses class switch recombination to IgG2a through its antioxidant function Journal of immunology (Baltimore, Md. 2010;184 (11):6177-6187 [PubMed]
  • Guikema Jeroen E. J., Stavnezer Janet, Schrader Carol E. The role of Apex2 in class-switch recombination of immunoglobulin genes International immunology 2010;22 (3):213; author reply 213-213; author reply 214 [PubMed]

2009

  • Schrader Carol E., Guikema Jeroen E. J., Wu Xiaoming, Stavnezer Janet The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364 (1517):645-652 [PubMed]

2008

  • Stavnezer Janet, Guikema Jeroen E. J., Schrader Carol E. Mechanism and regulation of class switch recombination Annual review of immunology 2008;26:261-292 [PubMed]
  • Guikema Jeroen E. J., Schrader Carol E., Leus Niek G. J., Ucher Anna, Linehan Erin K., Werling Uwe, Edelmann Winfried, Stavnezer Janet Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching Journal of immunology (Baltimore, Md. 2008;181 (12):8450-8459 [PubMed]
  • Guikema Jeroen E. J., Schuuring Ed, Kluin Philip M. Structure and consequences of IGH switch breakpoints in Burkitt lymphoma Journal of the National Cancer Institute. Monographs 2008;39 (39):32-36 [PubMed]

2007

  • Schrader Carol E., Guikema Jeroen E. J., Linehan Erin K., Selsing Erik, Stavnezer Janet Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair Journal of immunology (Baltimore, Md. 2007;179 (9):6064-6071 [PubMed]
  • Guikema Jeroen E. J., Linehan Erin K., Tsuchimoto Daisuke, Nakabeppu Yusaku, Strauss Phyllis R., Stavnezer Janet, Schrader Carol E. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination Journal of experimental medicine 2007;204 (12):3017-3026 [PubMed]

2006

  • Guikema Jeroen E. J., de Boer-Bergsma Rinny W., Akkermans Karine, Schuuring Ed, Kluin Philip M. H2AX is not affected in mantle cell lymphoma with 11q23 deletion Genes, chromosomes & cancer 2006;45 (4):426-427 [PubMed]
  • Guikema Jeroen E. J., de Boer Conny, Haralambieva Eugenia, Smit Laura A., van Noesel Carel J. M., Schuuring Ed, Kluin Philip M. IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination Genes, chromosomes & cancer 2006;45 (9):808-819 [PubMed]

2005

  • Guikema Jeroen E. J., Fenton James A. L., de Boer Conny, Kleiverda Karin, Brink Antoinette A. T. P., Raap Anton K., Estrov Zeev, Schuuring Ed, Kluin Philip M. Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination Genes, chromosomes & cancer 2005;42 (2):164-169 [PubMed]
  • Guikema Jeroen E. J., Rosati Stefano, Akkermans Karine, Bende Richard J., van Noesel Carel J. M., van Krieken Johan H., Hansmann Martin L., Schuuring Ed, Kluin Philip M. Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients Blood 2005;105 (7):2997-2998 [PubMed]

2004

  • Guikema Jeroen E. J., Vellenga Edo, Abdulahad Wayel H., Hovenga Sjoerd, Bos Nicolaas A. CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases British journal of haematology 2004;124 (3):299-308 [PubMed]
  • Guikema Jeroen E. J., Hovenga Sjoerd, Vellenga Edo, Bos Nicolaas A. Heterogeneity in the multiple myeloma tumor clone Leukemia & lymphoma 2004;45 (5):857-871 [PubMed]
  • Haralambieva Eugenia, Schuuring Ed, Rosati Stefano, van Noesel Carel, Jansen Patty, Appel Inge, Guikema Jeroen, Wabinga Henry, Bleggi-Torres Luiz Fernando, Lam King, van den Berg Eva, Mellink Clemens, van Zelderen-Bhola Shama, Kluin Philip Interphase fluorescence in situ hybridization for detection of 8q24/MYC breakpoints on routine histologic sections: validation in Burkitt lymphomas from three geographic regions Genes, chromosomes & cancer 2004;40 (1):10-18 [PubMed]

2003

  • Guikema Jeroen E. J., Hovenga Sjoerd, Vellenga Edo, Conradie Jelle J., Abdulahad Wayel H., Bekkema Roelof, Smit Jan W., Zhan Fenghuang, Shaughnessy John, Bos Nicolaas A. CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease British journal of haematology 2003;121 (1):36-43 [PubMed]
  • Smit Laura A., Bende Richard J., Aten Jan, Guikema Jeroen E. J., Aarts Wilhelmina M., van Noesel Carel J. M. Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype Cancer research 2003;63 (14):3894-3898 [PubMed]

2002

  • Guikema Jeroen E. J., Vellenga Edo, Bakkus Marleen H. C., Bos Nicolaas A. Myeloma clonotypic B cells are hampered in their ability to undergo B-cell differentiation in vitro British journal of haematology 2002;119 (1):54-61 [PubMed]

2001

  • de Bont E. S., Guikema J. E., Scherpen F., Meeuwsen T., Kamps W. A., Vellenga E., Bos N. A. Mobilized human CD34+ hematopoietic stem cells enhance tumor growth in a nonobese diabetic/severe combined immunodeficient mouse model of human non-Hodgkin's lymphoma Cancer research 2001;61 (20):7654-7659 [PubMed]

2000

  • Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation Bone marrow transplantation 2000;25 (7):723-728 [PubMed]
  • Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study. Belgium-Dutch Hematology-Oncology Group Blood 2000;96 (1):63-70 [PubMed]

1999

  • Multiple myeloma related cells in patients undergoing autologous peripheral blood stem cell transplantation British journal of haematology 1999;104 (4):748-754 [PubMed]