K.H.E.W.J. Sliepen PhD publications

2020

• Derking Ronald, Allen Joel D., Cottrell Christopher A., Sliepen Kwinten, Seabright Gemma E., Lee Wen-Hsin, Rantalainen Kimmo, Antanasijevic Aleksandar, Copps Jeffrey, Yasmeen Anila, van der Woude Patricia, de Taeye Steven W., van den Kerkhof Tom L.G.M., Klasse P.J., Ozorowski Gabriel, van Gils Marit J., Moore John P., Ward Andrew B., Crispin Max, Sanders Rogier W. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike bioRxiv 2020
• Kalemera Mphatso D, Capella-Pujol Joan, Chumbe Ana, Underwood Alexander, Bull Rowena A, Schinkel Janke, Sliepen Kwinten, Grove Joe Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins Journal of general virology 2020 [PubMed]
• Marín María Q., Sliepen Kwinten, García-Arriaza Juan, Koekkoek Sylvie M., Pérez Patricia, Sorzano Carlos Óscar S., Gómez Carmen E., Sanders Rogier W., Esteban Mariano Optimized hepatitis C virus (HCV) e2 glycoproteins and their immunogenicity in combination with MVA-HCV Vaccines 2020;8 (3):1-25 [PubMed]
• Brouwer Philip J.M., Caniels Tom G., van der Straten Karlijn, Snitselaar Jonne L., Aldon Yoann, Bangaru Sandhya, Torres Jonathan L., Okba Nisreen M.A., Claireaux Mathieu, Kerster Gius, Bentlage Arthur E.H., van Haaren Marlies M., Guerra Denise, Burger Judith A., Schermer Edith E., Verheul Kirsten D., van der Velde Niels, van der Kooi Alex, van Schooten Jelle, van Breemen Mariëlle J., Bijl Tom P.L., Sliepen Kwinten, Aartse Aafke, Derking Ronald, Bontjer Ilja, Kootstra Neeltje A., Joost Wiersinga W., Vidarsson Gestur, Haagmans Bart L., Ward Andrew B., de Bree Godelieve J., Sanders Rogier W., van Gils Marit J. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Science 2020;369 (6504):643-650 [PubMed]
• Brouwer Philip J. M., Brinkkemper Mitch, Maisonnasse Pauline, Dereuddre-Bosquet Nathalie, Grobben Marloes, Claireaux Mathieu, de Gast Marlon, Marlin Romain, Chesnais Virginie, Diry Ségolène, Allen Joel D., Watanabe Yasunori, Giezen Julia M., Kerster Gius, Turner Hannah L., van der Straten Karlijn, van der Linden Cynthia A., Aldon Yoann, Naninck Thibaut, Bontjer Ilja, Burger Judith A., Poniman Meliawati, Mykytyn Anna Z., Okba Nisreen M. A., Schermer Edith E., van Breemen Marielle J., Ravichandran Rashmi, Caniels Tom G., van Schooten Jelle, Kahlaoui Nidhal, Contreras Vanessa, Lemaitre Julien, Chapon Catherine, Ho Tsong Fang Raphaël, Villaudy Julien, Sliepen Kwinten, van der Velden Yme U., Haagmans Bart L., de Bree Godelieve J., Ginoux Eric, Ward Andrew B., Crispin Max, King Neil P., van der Werf Sylvie, van Gils Marit J., Grand Roger Le, Sanders Rogier W. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection bioRxiv 2020

2019

• Brouwer Philip J. M., Antanasijevic Aleksandar, Berndsen Zachary, Yasmeen Anila, Fiala Brooke, Bijl Tom P. L., Bontjer Ilja, Bale Jacob B., Sheffler William, Allen Joel D., Schorcht Anna, Burger Judith A., Camacho Miguel, Ellis Daniel, Cottrell Christopher A., Behrens Anna-Janina, Catalano Marco, del Moral-Sánchez Iván, Ketas Thomas J., LaBranche Celia, van Gils Marit J., Sliepen Kwinten, Stewart Lance J., Crispin Max, Montefiori David C., Baker David, Moore John P., Klasse Per Johan, Ward Andrew B., King Neil P., Sanders Rogier W. Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle Nature communications 2019;10 (1):4272 [PubMed]
• Brinkkemper Mitch, Sliepen Kwinten Nanoparticle vaccines for inducing HIV-1 neutralizing antibodies Vaccines 2019;7 (3) [PubMed]
• de Taeye Steven W., Go Eden P., Sliepen Kwinten, de la Peña Alba Torrents, Badal Kimberly, Medina-Ramírez Max, Lee Wen-Hsin, Desaire Heather, Wilson Ian A., Moore John P., Ward Andrew B., Sanders Rogier W. Stabilization of the V2 loop improves the presentation of V2 loop associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers Journal of biological chemistry 2019;294 (14):5616-5631 [PubMed]
• del Moral-Sánchez Iván, Sliepen Kwinten Strategies for inducing effective neutralizing antibody responses against HIV-1 Expert review of vaccines 2019;18 (11):1127-1143 [PubMed]
• Sliepen Kwinten, Han Byung Woo, Bontjer Ilja, Mooij Petra, Garces Fernando, Behrens Anna-Janina, Rantalainen Kimmo, Kumar Sonu, Sarkar Anita, Brouwer Philip J. M., Hua Yuanzi, Tolazzi Monica, Schermer Edith, Torres Jonathan L., Ozorowski Gabriel, van der Woude Patricia, de la Peña Alba Torrents, van Breemen Mariëlle J., Camacho-Sánchez Juan Miguel, Burger Judith A., Medina-Ramírez Max, González Nuria, Alcami Jose, LaBranche Celia, Scarlatti Gabriella, van Gils Marit J., Crispin Max, Montefiori David C., Ward Andrew B., Koopman Gerrit, Moore John P., Shattock Robin J., Bogers Willy M., Wilson Ian A., Sanders Rogier W. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence Nature communications 2019;10 (1) [PubMed]

2018

• Torrents de la Peña Alba, de Taeye Steven W., Sliepen Kwinten, LaBranche Celia C., Burger Judith A., Schermer Edith E., Montefiori David C., Moore John P., Klasse Per Johan, Sanders Rogier W. Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations Journal of virology 2018;92 (8):e01957-17 [PubMed]
• de Taeye Steven W., Torrents de la Peña Alba, Vecchione Andrea, Scutigliani Enzo, Sliepen Kwinten, Burger Judith A., van der Woude Patricia, Schorcht Anna, Schermer Edith E., van Gils Marit J., LaBranche Celia C., Montefiori David C., Wilson Ian A., Moore John P., Ward Andrew B., Sanders Rogier W. Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers Journal of biological chemistry 2018;293 (5):1688-1701 [PubMed]

2017

• Medina-Ramírez Max, Garces Fernando, Escolano Amelia, Skog Patrick, de Taeye Steven W., del Moral-Sanchez Ivan, McGuire Andrew T., Yasmeen Anila, Behrens Anna-Janina, Ozorowski Gabriel, van den Kerkhof Tom L. G. M., Freund Natalia T., Dosenovic Pia, Hua Yuanzi, Gitlin Alexander D., Cupo Albert, van der Woude Patricia, Golabek Michael, Sliepen Kwinten, Blane Tanya, Kootstra Neeltje, van Breemen Mariëlle J., Pritchard Laura K., Stanfield Robyn L., Crispin Max, Ward Andrew B., Stamatatos Leonidas, Klasse Per Johan, Moore John P., Nemazee David, Nussenzweig Michel C., Wilson Ian A., Sanders Rogier W. Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo Journal of experimental medicine 2017;214 (9):2573-2590 [PubMed]
• Torrents de la Peña Alba, Julien Jean-Philippe, de Taeye Steven W., Garces Fernando, Guttman Miklos, Ozorowski Gabriel, Pritchard Laura K., Behrens Anna-Janina, Go Eden P., Burger Judith A., Schermer Edith E., Sliepen Kwinten, Ketas Thomas J., Pugach Pavel, Yasmeen Anila, Cottrell Christopher A., Torres Jonathan L., Vavourakis Charlotte D., van Gils Marit J., Labranche Celia, Montefiori David C., Desaire Heather, Crispin Max, Klasse Per Johan, Lee Kelly K., Moore John P., Ward Andrew B., Wilson Ian A., Sanders Rogier W. Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization Cell reports 2017;20 (8):1805-1817 [PubMed]

2016

• Sliepen Kwinten, Sanders Rogier W. HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies Expert review of vaccines 2016;15 (3):349-365 [PubMed]
• Sliepen Kwinten HIV-1 envelope trimer fusion proteins and their applications 2016. 183p. ISBN 9789462993594. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Berkhout B.; Co-supervisor: Sanders R. W.)

2015

• Lee Jeong Hyun, Leaman Daniel P., Kim Arthur S., Torrents de la Peña Alba, Sliepen Kwinten, Yasmeen Anila, Derking Ronald, Ramos Alejandra, de Taeye Steven W., Ozorowski Gabriel, Klein Florian, Burton Dennis R., Nussenzweig Michel C., Poignard Pascal, Moore John P., Klasse Per Johan, Sanders Rogier W., Zwick Michael B., Wilson Ian A., Ward Andrew B. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature communications 2015;6:8167 [PubMed]
• Sliepen Kwinten, Medina-Ramírez Max, Yasmeen Anila, Moore John P., Klasse Per Johan, Sanders Rogier W. Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers Virology 2015;486:116-120 [PubMed]
• Kong Leopold, Torrents de la Peña Alba, Deller Marc C., Garces Fernando, Sliepen Kwinten, Hua Yuanzi, Stanfield Robyn L., Sanders Rogier W., Wilson Ian A. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer Acta crystallographica. Section D, Biological crystallography 2015;71 (Part 10):2099-2108 [PubMed]
• Derking Ronald, Ozorowski Gabriel, Sliepen Kwinten, Yasmeen Anila, Cupo Albert, Torres Jonathan L., Julien Jean-Philippe, Lee Jeong Hyun, van Montfort Thijs, de Taeye Steven W., Connors Mark, Burton Dennis R., Wilson Ian A., Klasse Per-Johan, Ward Andrew B., Moore John P., Sanders Rogier W. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer PLoS pathogens 2015;11 (3):e1004767 [PubMed]
• Sliepen Kwinten, van Montfort Thijs, Ozorowski Gabriel, Pritchard Laura K., Crispin Max, Ward Andrew B., Sanders Rogier W. Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer Biomolecules 2015;5 (4):2919-2934 [PubMed]
• Sliepen Kwinten, van Montfort Thijs, Melchers Mark, Isik Gözde, Sanders Rogier W. Immunosilencing a highly immunogenic protein trimerization domain Journal of biological chemistry 2015;290 (12):7436-7442 [PubMed]
• Hu Joyce K., Crampton Jordan C., Cupo Albert, Ketas Thomas, van Gils Marit J., Sliepen Kwinten, de Taeye Steven W., Sok Devin, Ozorowski Gabriel, Deresa Isaiah, Stanfield Robyn, Ward Andrew B., Burton Dennis R., Klasse Per Johan, Sanders Rogier W., Moore John P., Crotty Shane Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity Journal of virology 2015;89 (20):10383-10398 [PubMed]
• Sliepen Kwinten, Ozorowski Gabriel, Burger Judith A., van Montfort Thijs, Stunnenberg Melissa, Labranche Celia, Montefiori David C., Moore John P., Ward Andrew B., Sanders Rogier W. Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity Retrovirology 2015;12 (1):82 [PubMed]

2014

• Huang Jinghe, Kang Byong H., Pancera Marie, Lee Jeong Hyun, Tong Tommy, Feng Yu, Imamichi Hiromi, Georgiev Ivelin S., Chuang Gwo-Yu, Druz Aliaksandr, Doria-Rose Nicole A., Laub Leo, Sliepen Kwinten, van Gils Marit J., de la Peña Alba Torrents, Derking Ronald, Klasse Per-Johan, Migueles Stephen A., Bailer Robert T., Alam Munir, Pugach Pavel, Haynes Barton F., Wyatt Richard T., Sanders Rogier W., Binley James M., Ward Andrew B., Mascola John R., Kwong Peter D., Connors Mark Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface Nature 2014;515 (7525):138-142 [PubMed]
• Isik Gözde, Sliepen Kwinten, van Montfort Thijs, Sanders Rogier W. Enhanced immunogenicity of HIV-1 envelope gp140 proteins fused to APRIL PLoS ONE 2014;9 (9):e107683 [PubMed]
• Blattner Claudia, Lee Jeong Hyun, Sliepen Kwinten, Derking Ronald, Falkowska Emilia, de la Peña Alba Torrents, Cupo Albert, Julien Jean-Philippe, van Gils Marit, Lee Peter S., Peng Wenjie, Paulson James C., Poignard Pascal, Burton Dennis R., Moore John P., Sanders Rogier W., Wilson Ian A., Ward Andrew B. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Immunity 2014;40 (5):669-680 [PubMed]