PhD K.H.E.W.J. Sliepen publications

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Publications K.H.E.W.J. Sliepen PhD

Position
Research Associate
Main activities
Research
Specialisation
hepatitis C virus (HCV), HIV-1, envelope glycoproteins, vaccines, nanoparticles
Focus of research

Designing hepatitis C virus (HCV) E1E2 glycoproteins for structural studies and vaccine studies.

Producing and designing novel HIV-1 envelope glycoproteins.

2019

  • Brouwer Philip J. M., Antanasijevic Aleksandar, Berndsen Zachary, Yasmeen Anila, Fiala Brooke, Bijl Tom P. L., Bontjer Ilja, Bale Jacob B., Sheffler William, Allen Joel D., Schorcht Anna, Burger Judith A., Camacho Miguel, Ellis Daniel, Cottrell Christopher A., Behrens Anna-Janina, Catalano Marco, del Moral-Sánchez Iván, Ketas Thomas J., LaBranche Celia, van Gils Marit J., Sliepen Kwinten, Stewart Lance J., Crispin Max, Montefiori David C., Baker David, Moore John P., Klasse Per Johan, Ward Andrew B., King Neil P., Sanders Rogier W. Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle Nature communications 2019;10 (1):4272 [PubMed]
  • Brinkkemper Mitch, Sliepen Kwinten Nanoparticle vaccines for inducing HIV-1 neutralizing antibodies Vaccines 2019;7 (3) [PubMed]
  • de Taeye Steven W., Go Eden P., Sliepen Kwinten, de la Peña Alba Torrents, Badal Kimberly, Medina-Ramírez Max, Lee Wen-Hsin, Desaire Heather, Wilson Ian A., Moore John P., Ward Andrew B., Sanders Rogier W. Stabilization of the V2 loop improves the presentation of V2 loop associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers Journal of biological chemistry 2019;294 (14):5616-5631 [PubMed]
  • del Moral-Sánchez Iván, Sliepen Kwinten Strategies for inducing effective neutralizing antibody responses against HIV-1 Expert review of vaccines 2019;18 (11):1127-1143 [PubMed]
  • Sliepen Kwinten, Han Byung Woo, Bontjer Ilja, Mooij Petra, Garces Fernando, Behrens Anna-Janina, Rantalainen Kimmo, Kumar Sonu, Sarkar Anita, Brouwer Philip J. M., Hua Yuanzi, Tolazzi Monica, Schermer Edith, Torres Jonathan L., Ozorowski Gabriel, van der Woude Patricia, de la Peña Alba Torrents, van Breemen Mariëlle J., Camacho-Sánchez Juan Miguel, Burger Judith A., Medina-Ramírez Max, González Nuria, Alcami Jose, LaBranche Celia, Scarlatti Gabriella, van Gils Marit J., Crispin Max, Montefiori David C., Ward Andrew B., Koopman Gerrit, Moore John P., Shattock Robin J., Bogers Willy M., Wilson Ian A., Sanders Rogier W. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence Nature communications 2019;10 (1) [PubMed]

2018

  • Torrents de la Peña Alba, de Taeye Steven W., Sliepen Kwinten, LaBranche Celia C., Burger Judith A., Schermer Edith E., Montefiori David C., Moore John P., Klasse Per Johan, Sanders Rogier W. Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations Journal of virology 2018;92 (8):e01957-17 [PubMed]
  • de Taeye Steven W., Torrents de la Peña Alba, Vecchione Andrea, Scutigliani Enzo, Sliepen Kwinten, Burger Judith A., van der Woude Patricia, Schorcht Anna, Schermer Edith E., van Gils Marit J., LaBranche Celia C., Montefiori David C., Wilson Ian A., Moore John P., Ward Andrew B., Sanders Rogier W. Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers Journal of biological chemistry 2018;293 (5):1688-1701 [PubMed]

2017

  • Medina-Ramírez Max, Garces Fernando, Escolano Amelia, Skog Patrick, de Taeye Steven W., del Moral-Sanchez Ivan, McGuire Andrew T., Yasmeen Anila, Behrens Anna-Janina, Ozorowski Gabriel, van den Kerkhof Tom L. G. M., Freund Natalia T., Dosenovic Pia, Hua Yuanzi, Gitlin Alexander D., Cupo Albert, van der Woude Patricia, Golabek Michael, Sliepen Kwinten, Blane Tanya, Kootstra Neeltje, van Breemen Mariëlle J., Pritchard Laura K., Stanfield Robyn L., Crispin Max, Ward Andrew B., Stamatatos Leonidas, Klasse Per Johan, Moore John P., Nemazee David, Nussenzweig Michel C., Wilson Ian A., Sanders Rogier W. Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo Journal of experimental medicine 2017;214 (9):2573-2590 [PubMed]
  • Torrents de la Peña Alba, Julien Jean-Philippe, de Taeye Steven W., Garces Fernando, Guttman Miklos, Ozorowski Gabriel, Pritchard Laura K., Behrens Anna-Janina, Go Eden P., Burger Judith A., Schermer Edith E., Sliepen Kwinten, Ketas Thomas J., Pugach Pavel, Yasmeen Anila, Cottrell Christopher A., Torres Jonathan L., Vavourakis Charlotte D., van Gils Marit J., Labranche Celia, Montefiori David C., Desaire Heather, Crispin Max, Klasse Per Johan, Lee Kelly K., Moore John P., Ward Andrew B., Wilson Ian A., Sanders Rogier W. Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization Cell reports 2017;20 (8):1805-1817 [PubMed]

2016

  • Sliepen Kwinten, Sanders Rogier W. HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies Expert review of vaccines 2016;15 (3):349-365 [PubMed]
  • Sliepen Kwinten HIV-1 envelope trimer fusion proteins and their applications 2016. 183p. ISBN 9789462993594. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Berkhout B.; Co-supervisor: Sanders R. W.)

2015

  • Lee Jeong Hyun, Leaman Daniel P., Kim Arthur S., Torrents de la Peña Alba, Sliepen Kwinten, Yasmeen Anila, Derking Ronald, Ramos Alejandra, de Taeye Steven W., Ozorowski Gabriel, Klein Florian, Burton Dennis R., Nussenzweig Michel C., Poignard Pascal, Moore John P., Klasse Per Johan, Sanders Rogier W., Zwick Michael B., Wilson Ian A., Ward Andrew B. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature communications 2015;6:8167 [PubMed]
  • Sliepen Kwinten, Medina-Ramírez Max, Yasmeen Anila, Moore John P., Klasse Per Johan, Sanders Rogier W. Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers Virology 2015;486:116-120 [PubMed]
  • Kong Leopold, Torrents de la Peña Alba, Deller Marc C., Garces Fernando, Sliepen Kwinten, Hua Yuanzi, Stanfield Robyn L., Sanders Rogier W., Wilson Ian A. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer Acta crystallographica. Section D, Biological crystallography 2015;71 (Part 10):2099-2108 [PubMed]
  • Derking Ronald, Ozorowski Gabriel, Sliepen Kwinten, Yasmeen Anila, Cupo Albert, Torres Jonathan L., Julien Jean-Philippe, Lee Jeong Hyun, van Montfort Thijs, de Taeye Steven W., Connors Mark, Burton Dennis R., Wilson Ian A., Klasse Per-Johan, Ward Andrew B., Moore John P., Sanders Rogier W. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer PLoS pathogens 2015;11 (3):e1004767 [PubMed]
  • Sliepen Kwinten, van Montfort Thijs, Ozorowski Gabriel, Pritchard Laura K., Crispin Max, Ward Andrew B., Sanders Rogier W. Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer Biomolecules 2015;5 (4):2919-2934 [PubMed]
  • Sliepen Kwinten, van Montfort Thijs, Melchers Mark, Isik Gözde, Sanders Rogier W. Immunosilencing a highly immunogenic protein trimerization domain Journal of biological chemistry 2015;290 (12):7436-7442 [PubMed]
  • Hu Joyce K., Crampton Jordan C., Cupo Albert, Ketas Thomas, van Gils Marit J., Sliepen Kwinten, de Taeye Steven W., Sok Devin, Ozorowski Gabriel, Deresa Isaiah, Stanfield Robyn, Ward Andrew B., Burton Dennis R., Klasse Per Johan, Sanders Rogier W., Moore John P., Crotty Shane Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity Journal of virology 2015;89 (20):10383-10398 [PubMed]
  • Sliepen Kwinten, Ozorowski Gabriel, Burger Judith A., van Montfort Thijs, Stunnenberg Melissa, Labranche Celia, Montefiori David C., Moore John P., Ward Andrew B., Sanders Rogier W. Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity Retrovirology 2015;12 (1):82 [PubMed]

2014

  • Huang Jinghe, Kang Byong H., Pancera Marie, Lee Jeong Hyun, Tong Tommy, Feng Yu, Imamichi Hiromi, Georgiev Ivelin S., Chuang Gwo-Yu, Druz Aliaksandr, Doria-Rose Nicole A., Laub Leo, Sliepen Kwinten, van Gils Marit J., de la Peña Alba Torrents, Derking Ronald, Klasse Per-Johan, Migueles Stephen A., Bailer Robert T., Alam Munir, Pugach Pavel, Haynes Barton F., Wyatt Richard T., Sanders Rogier W., Binley James M., Ward Andrew B., Mascola John R., Kwong Peter D., Connors Mark Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface Nature 2014;515 (7525):138-142 [PubMed]
  • Isik Gözde, Sliepen Kwinten, van Montfort Thijs, Sanders Rogier W. Enhanced immunogenicity of HIV-1 envelope gp140 proteins fused to APRIL PLoS ONE 2014;9 (9):e107683 [PubMed]
  • Blattner Claudia, Lee Jeong Hyun, Sliepen Kwinten, Derking Ronald, Falkowska Emilia, de la Peña Alba Torrents, Cupo Albert, Julien Jean-Philippe, van Gils Marit, Lee Peter S., Peng Wenjie, Paulson James C., Poignard Pascal, Burton Dennis R., Moore John P., Sanders Rogier W., Wilson Ian A., Ward Andrew B. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Immunity 2014;40 (5):669-680 [PubMed]

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