PhD M.A. Brehm publications

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Publications PhD M.A. Brehm

Position
Research Associate
Main activities
Research, Other
Specialisation
gait studies in neurmuscular disorders and cerebral palsy
Focus of research

Research focuses on functioning of patients with neuromuscular diseases (postpoliomyelitis syndrome (PPS)) and children with cerebral palsy (CP), including intervention studies on lower limb orthoses. Other areas of focus include reliability research on walking energy expenditure measures and on aerobic and anaerobic fitness testing.

2020

  • Meyns P., Kerkum Y. L., Brehm M. A., Becher J. G., Buizer A. I., Harlaar J. Ankle foot orthoses in cerebral palsy: Effects of ankle stiffness on trunk kinematics, gait stability and energy cost of walking European journal of paediatric neurology : EJPN 2020 [PubMed]
  • Nyalwidhe Julius O., Jurczyk Agata, Satish Basanthi, Redick Sambra, Qaisar Natasha, Trombly Melanie I., Vangala Pranitha, Racicot Riccardo, Bortell Rita, Harlan David M., Greiner Dale L., Brehm Michael A., Nadler Jerry L., Wang Jennifer P. Proteomic and transcriptional profiles of human stem cell-derived β cells following enteroviral challenge Microorganisms 2020;8 (2) [PubMed]

2019

  • Voorn Eric L., Koopman Fieke, Nollet Frans, Brehm Merel A. Aerobic exercise in adult neuromuscular rehabilitation: A survey of healthcare professionals Journal of rehabilitation medicine 2019;51 (7):518-524 [PubMed]
  • Youngblood Bradford A., Brock Emily C., Leung John, Falahati Rustom, Bryce Paul J., Bright Jessica, Williams Jason, Shultz Leonard D., Greiner Dale L., Brehm Michael A., Bebbington Christopher, Tomasevic Nenad AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice International archives of allergy and immunology 2019;180 (2):91-102 [PubMed]
  • Waterval Niels F. J., Nollet Frans, Harlaar Jaap, Brehm Merel-Anne Modifying ankle foot orthosis stiffness in patients with calf muscle weakness: gait responses on group and individual level Journal of NeuroEngineering and Rehabilitation 2019;16 (1):120 [PubMed]
  • Ploeger Hilde E., Waterval Niels F. J., Nollet Frans, Bus Sicco A., Brehm Merel-Anne Stiffness modification of two ankle-foot orthosis types to optimize gait in individuals with non-spastic calf muscle weakness - a proof-of-concept study JOURNAL OF FOOT AND ANKLE RESEARCH 2019;12:41 [PubMed]

2018

  • Waterval Niels F. J., Brehm Merel-Anne, Ploeger Hilde E., Nollet Frans, Harlaar Jaap Compensations in lower limb joint work during walking in response to unilateral calf muscle weakness Gait & posture 2018;66:38-44 [PubMed]
  • Voorn Eric L., Koopman Fieke S., Brehm Merel A., Beelen Anita, de Haan Arnold, Gerrits Karin H. L., Nollet Frans Correction: Aerobic Exercise Training in Post-Polio Syndrome: Process Evaluation of a Randomized Controlled Trial PLoS ONE 2018;13 (1):e0192338 [PubMed]
  • Kerkum Yvette L., Houdijk Han, Buizer Annemieke I., Brehm Merel A., Harlaar Jaap O 016 - Investigating the roll-over shape in children with cerebral palsy walking with and without ankle foot orthoses Gait & posture 2018;65:29-30
  • Visser-Meily J.M.A., Geurts A. C. H., Horemans A. M. C., van Groenestijn A. C., Koopman F. S., Voet N., Voorn E. L., Bakker M., Brehm M. A., Nollet F. Samen sterker: FACTS-2-NMD, het gezamenlijke onderzoeksprogramma naar revalidatie bij spierziekten Nederlands Tijdschrift voor Revalidatiegeneeskunde 2018;05 (december):221

2017

  • Kooreman Nigel G., de Almeida Patricia E., Stack Jonathan P., Nelakanti Raman V., Diecke Sebastian, Shao Ning-Yi, Swijnenburg Rutger-Jan, Sanchez-Freire Veronica, Matsa Elena, Liu Chun, Connolly Andrew J., Hamming Jaap F., Quax Paul H. A., Brehm Michael A., Greiner Dale L., Shultz Leonard D., Wu Joseph C. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics Cell reports 2017;20 (8):1978-1990 [PubMed]
  • Koopman Fieke S., Brehm Merel A., Beelen Anita, Voet Nicole, Bleijenberg Gijs, Geurts Alexander, Nollet Frans Cognitive behavioural therapy for reducing fatigue in post-polio syndrome and in facioscapulohumeral dystrophy: A comparison Journal of rehabilitation medicine 2017;49 (7):585-590 [PubMed]
  • Brehm Merel-Anne, Verduijn Suzan, Bon Jurgen, Bredt Nicoline, Nollet Frans COMPARISON OF TWO 6-MINUTE WALK TESTS TO ASSESS WALKING CAPACITY IN POLIO SURVIVORS Journal of rehabilitation medicine 2017;49 (9):732-737 [PubMed]
  • Bolster Eline A. M., Balemans Astrid C. J., Brehm Merel-Anne, Buizer Annemieke I., Dallmeijer Annet J. Energy cost during walking in association with age and body height in children and young adults with cerebral palsy Gait & posture 2017;54:119-126 [PubMed]
  • Ploeger Hilde E., Bus Sicco A., Nollet Frans, Brehm Merel-Anne Gait patterns in association with underlying impairments in polio survivors with calf muscle weakness Gait & posture 2017;58:146-153 [PubMed]
  • Balemans Astrid C., Bolster Eline A., Brehm Merel-Anne, Dallmeijer Annet J. Physical Strain: A New Perspective on Walking in Cerebral Palsy Archives of physical medicine and rehabilitation 2017;98 (12):2507-2513 [PubMed]
  • Waterval Niels F. J., Nollet Frans, Harlaar Jaap, Brehm Merel-Anne Precision orthotics: optimising ankle foot orthoses to improve gait in patients with neuromuscular diseases; protocol of the PROOF-AFO study, a prospective intervention study BMJ open 2017;7 (2):e013342 [PubMed]

2016

  • Voorn Eric L., Koopman Fieke S., Brehm Merel A., Beelen Anita, de Haan Arnold, Gerrits Karin H. L., Nollet Frans Aerobic Exercise Training in Post-Polio Syndrome: Process Evaluation of a Randomized Controlled Trial PLoS ONE 2016;11 (7):e0159280 [PubMed]
  • Kerkum Yvette L., Harlaar Jaap, Buizer Annemieke I., van den Noort Josien C., Becher Jules G., Brehm Merel-Anne An individual approach for optimizing ankle-foot orthoses to improve mobility in children with spastic cerebral palsy walking with excessive knee flexion Gait & posture 2016;46:104-111 [PubMed]
  • Kerkum Yvette L. Maximizing the efficacy of ankle-foot orthoses in children with cerebral palsy 2016. 200p. ISBN 9789064649639. [UvA Dissertations Online] Vrije Universiteit Amsterdam: VUmc. (Supervisors: Harlaar Jaap, Becher J. G.; Co-supervisors: Brehm M. A., Buizer A. I.)
  • Koopman Fieke S., Voorn Eric L., Beelen Anita, Bleijenberg Gijs, de Visser Marianne, Brehm Merel A., Nollet Frans No Reduction of Severe Fatigue in Patients With Postpolio Syndrome by Exercise Therapy or Cognitive Behavioral Therapy: Results of an RCT Neurorehabilitation and neural repair 2016;30 (5):402-410 [PubMed]
  • Brehm M.A., Waterval N.F.J., Harlaar J., Nollet F. Op zoek naar de juiste enkelvoetorthese voor de juiste patiënt Nederlands Tijdschrift voor Revalidatiegeneeskunde 2016 (september):176-177
  • Koopman Fieke S. Treating fatigue in post-polio syndrome 2016. 268p. ISBN 9789462333574. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Nollet F., de Visser M.; Co-supervisors: Beelen J. A. J. M., Brehm M. A.)

2015

  • Kerkum Yvette L., Brehm Merel-Anne, van Hutten Kim, van den Noort Josien C., Harlaar Jaap, Becher Jules G., Buizer Annemieke I. Acclimatization of the gait pattern to wearing an ankle-foot orthosis in children with spastic cerebral palsy Clinical biomechanics (Bristol, Avon) 2015;30 (6):617-622 [PubMed]
  • Ploeger Hilde, Bus Sicco, Nollet Frans, Brehm Merel Het variëren van de enkel-voetorthesestijfheid. Effecten op het lopen bij mensen met kuitspierzwakte. Een pilotstudie Orthopedische Techniek 2015;2015 (juni):14-16
  • Kerkum Yvette L., Buizer Annemieke I., van den Noort Josien C., Becher Jules G., Harlaar Jaap, Brehm Merel-Anne The Effects of Varying Ankle Foot Orthosis Stiffness on Gait in Children with Spastic Cerebral Palsy Who Walk with Excessive Knee Flexion PLoS ONE 2015;10 (11):e0142878 [PubMed]
  • Kerkum Yvette L., Houdijk Han, Brehm Merel-Anne, Buizer Annemieke I., Kessels Manon L. C., Sterk Arjan, van den Noort Josien C., Harlaar Jaap The Shank-to-Vertical-Angle as a parameter to evaluate tuning of Ankle-Foot Orthoses Gait & posture 2015;42 (3):269-274 [PubMed]

2014

  • Brehm Merel-Anne, Kempen Jiska C. E., van der Kooi Anneke J., de Groot Imelda J. M., van den Bergen Janneke C., Verschuuren Jan J. G. M., Niks Erik H., Harlaar Jaap Age-related longitudinal changes in metabolic energy expenditure during walking in boys with Duchenne muscular dystrophy PLoS ONE 2014;9 (12):e115200 [PubMed]
  • Ploeger Hilde E., Bus Sicco A., Brehm Merel-Anne, Nollet Frans Ankle-foot orthoses that restrict dorsiflexion improve walking in polio survivors with calf muscle weakness Gait & posture 2014;40 (3):391-398 [PubMed]
  • Brehm Merel, Nollet Frans Beenorthesen bij neuromusculaire aandoeningenAmsterdam: Reed Business Education; 2014. ISBN 9789035238145
  • Brehm Merel-Anne, Nollet Frans Beenorthesen bij neuromusculaire aandoeningen Orthopedische Techniek 2014;2014 (november):25-25
  • Kerkum Yvette L., Brehm Merel-Anne, Buizer Annemieke I., van den Noort Josien C., Becher Jules G., Harlaar Jaap Defining the mechanical properties of a spring-hinged ankle foot orthosis to assess its potential use in children with spastic cerebral palsy Journal of applied biomechanics 2014;30 (6):728-731 [PubMed]
  • Brehm M. A., Dallmeijer A. De generaliseerbaarheidstheorie voor het schatten van de betrouwbaarheid, een methodische beschouwing FysioPraxis 2014;2014 (februari):36-37
  • Dallmeijer A. J., Bolster E., Balemans A.C.J., Brehm M. A., Buizer A.I., Doorenbosch C. A. M., Becher J. G. Klinische inspanningsanalyse bij kinderen met beperkingen in de loopvaardigheid Nederlands Tijdschrift voor Revalidatiegeneeskunde 2014;2014 (1):31-34
  • Koopman Fieke S., Brehm Merel A., Heerkens Yvonne F., Nollet Frans, Beelen Anita Measuring fatigue in polio survivors: content comparison and reliability of the Fatigue Severity Scale and the Checklist Individual Strength Journal of rehabilitation medicine 2014;46 (8):761-767 [PubMed]
  • Brehm Merel-Anne, Balemans Astrid C. J., Becher Jules G., Dallmeijer Annet J. Reliability of a progressive maximal cycle ergometer test to assess peak oxygen uptake in children with mild to moderate cerebral palsy Physical therapy 2014;94 (1):121-128 [PubMed]
  • Voorn Eric L., Brehm Merel A., Beelen Anita, de Haan Arnold, Nollet Frans, Gerrits Karin H. L. Reliability of contractile properties of the knee extensor muscles in individuals with post-polio syndrome PLoS ONE 2014;9 (7):e101660 [PubMed]
  • Kempen J. C. E., Harlaar J., van der Kooi A. J., de Groot I. J. M., van den Bergen J. C., Niks E. H., Verschuuren J. J. G. M., Brehm M. A. Reliability of the walking energy cost test and the six-minute walk test in boys with Duchenne muscular dystrophy Neuromuscular disorders 2014;24 (3):216-221 [PubMed]

2013

  • Kerkum Yvette L., Harlaar Jaap, Buizer Annemieke I., van den Noort Josien C., Becher Jules G., Brehm Merel-Anne Optimising Ankle Foot Orthoses for children with cerebral palsy walking with excessive knee flexion to improve their mobility and participation; protocol of the AFO-CP study BMC pediatrics 2013;13:17 [PubMed]
  • Willemse Lydia, Brehm Merel A., Scholtes Vanessa A., Jansen Laura, Woudenberg-Vos Hester, Dallmeijer Annet J. Reliability of isometric lower-extremity muscle strength measurements in children with cerebral palsy: implications for measurement design Physical therapy 2013;93 (7):935-941 [PubMed]
  • Dallmeijer Annet J., Scholtes Vanessa A. B., Brehm Merel-Anne, Becher Jules G. Test-Retest Reliability of the 20-sec Wingate Test to Assess Anaerobic Power in Children with Cerebral Palsy American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2013;92 (9):762-767 [PubMed]

2012

  • Brehm Merel-Anne, Scholtes Vanessa A., Dallmeijer Annet J., Twisk Jos W., Harlaar Jaap The importance of addressing heteroscedasticity in the reliability analysis of ratio-scaled variables: an example based on walking energy-cost measurements Developmental medicine and child neurology 2012;54 (3):267-273 [PubMed]

2011

  • Brehm Merel, Bus Sicco A., Harlaar Jaap, Nollet Frans A candidate core set of outcome measures based on the International Classification of Functioning, Disability and Health for clinical studies on lower limb orthoses Prosthetics and orthotics international 2011;35 (3):269-277 [PubMed]
  • Brehm Merel, Nollet Frans Beenorthesen naar maat bij neuromusculaire aandoeningen Orthopedische Techniek 2011;2011 (dec):7-9

2010

  • Grunt Sebastian, van Kampen Petra J., van der Krogt Marjolein M., Brehm Merel-Anne, Doorenbosch Caroline A. M., Becher Jules G. Reproducibility and validity of video screen measurements of gait in children with spastic cerebral palsy Gait & posture 2010;31 (4):489-494 [PubMed]
  • Harlaar Jaap, Brehm Merel, Becher Jules G., Bregman Daan J. J., Buurke Jaap, Holtkamp Fred, de Groot Vincent, Nollet Frans Studies examining the efficacy of Ankle Foot Orthoses should report activity level and mechanical evidence Prosthetics and orthotics international 2010;34 (3):327-335 [PubMed]

2008

  • Brehm Merel-Anne, Harlaar Jaap, Schwartz Michael Effect of ankle-foot orthoses on walking efficiency and gait in children with cerebral palsy Journal of rehabilitation medicine 2008;40 (7):529-534 [PubMed]
  • Brehm Merel-Anne, Knol Dirk L., Harlaar Jaap Methodological considerations for improving the reproducibility of walking efficiency outcomes in clinical gait studies Gait & posture 2008;27 (2):196-201 [PubMed]

2007

  • Brehm Merel-Anne, Beelen Anita, Doorenbosch Caroline A. M., Harlaar Jaap, Nollet Frans Effect of carbon-composite knee-ankle-foot orthoses on walking efficiency and gait in former polio patients Journal of rehabilitation medicine 2007;39 (8):651-657 [PubMed]
  • Brehm Merel-Anne, Becher Jules, Harlaar Jaap Reproducibility evaluation of gross and net walking efficiency in children with cerebral palsy Developmental medicine and child neurology 2007;49 (1):45-48 [PubMed]
  • Brehm Merel-Anne The clinical assessment of energy expenditure in pathological gaitWageningen: Pons; 2007. 181p. ISBN 9789064641398. [UvA Dissertations Online] VUmc: Rehabilitation Medicine. (Supervisors: Nollet F., Lankhorst G. J.; Co-supervisor: Harlaar J.)

2006

  • Brehm Merel-Anne, Nollet Frans, Harlaar Jaap Energy demands of walking in persons with postpoliomyelitis syndrome: relationship with muscle strength and reproducibility Archives of physical medicine and rehabilitation 2006;87 (1):136-140 [PubMed]

2004

  • Brehm M.-A., Harlaar J., Groepenhof H. Validation of the portable VmaxST system for oxygen-uptake measurement Gait & posture 2004;20 (1):67-73 [PubMed]