PhD M.F. Bijlsma publications

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Publications PhD M.F. Bijlsma

Position
Research Associate
Main activities
Research
Specialisation
The biology of upper GI cancers
Focus of research

My lab studies the biology that underlies the growth and therapy resistance of pancreatic and esophageael cancer. Models in my lab range from cell culture systems, mouse experiments, biobanking and the analysis of predictive and prognostic markers and profiles in large cohorts. Most of these have been generated through our live biobanking. 


One of the most typical features of upper GI cancers is the abundance of non-cancerous cells and material – the stroma. The stroma exerts both tumor-promoting as well as -limiting properties. We aim to identify which signals mediate critical tumor-stroma crosstalk, and whether we can use this to target tumor growth and drug resistance. In addition, we develop blood-borne markers to stratify patients for stroma-targeting treatments.


Many events that shape the developing embryo are regulated by the Hedgehog proteins. In the adult body, activity of these proteins is limited, but reactivation of the pathway is thought to contribute to pancreatic cancer. Several lines of research in my lab deal with the production and transport, but also the reception and interpretation of this ligand.


To construct the relevant experimental models needed to study cancer, I have founded the AMC biobank pancreatic carcinoma – BioPAN and co-coordinate the esophageal BiOES biobank. For these biobanks we accrue and store blood samples, tissue, and clinical data. Analyses on these materials include expression profiling and measurements of serum markers. BioPAN closely collaborates with the nation-wide PancreasParel biobank of which I am the coordinator, and the AMC-VUmc Liquid Biopsy Center that I co-head. Our expression profiling efforts have enabled us to identify subgroups of patients that differ in their clinical outcome and other clinically important parameters. 


The lethality of pancreatic cancer relies on the presence of so called cancer stem cells. Current tools to identify these cells have serious shortcomings. We have adapted tracing methods to trace the offspring of a single cell in tumors grown from these cells. These allow us to study the population of cancer stem cells that are thought to contribute to pancreatic cancer growth.
 

2020

  • le Large Tessa Y. S., Meijer Laura L., Paleckyte Rosita, Boyd Lenka N. C., Kok Bart, Wurdinger Thomas, Schelfhorst Tim, Piersma Sander R., Pham Thang V., van Grieken Nicole C. T., Zonderhuis Barbara M., Daams Freek, van Laarhoven Hanneke W. M., Bijlsma Maarten F., Jimenez Connie R., Giovannetti Elisa, Kazemier Geert Combined Expression of Plasma Thrombospondin-2 and CA19-9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach oncologist 2020 [PubMed]
  • Steins Anne, van Mackelenbergh Madelaine G., van der Zalm Amber P., Klaassen Remy, Serrels Bryan, Goris Sandrine G., Kocher Hemant M., Waasdorp Cynthia, de Jong Joan H., Tekin Cansu, Besselink Marc G., Busch Olivier R., van de Vijver Marc J., Verheij Joanne, Dijk Frederike, van Tienhoven Geertjan, Wilmink Johanna W., Medema Jan Paul, van Laarhoven Hanneke W. M., Bijlsma Maarten F. High-grade mesenchymal pancreatic ductal adenocarcinoma drives stromal deactivation through CSF-1 EMBO reports 2020 [PubMed]
  • Stroes Charlotte I., Schokker Sandor, Creemers Aafke, Molenaar Remco J., Hulshof Maarten C. C. M., van der Woude Stephanie O., Bennink Roel J., Mathôt Ron A. A., Krishnadath Kausilia K., Punt Cornelis J. A., Verhoeven Rob H. A., van Oijen Martijn G. H., Creemers Geert-Jan, Nieuwenhuijzen Grard A. P., van der Sangen Maurice J. C., Beerepoot Laurens V., Heisterkamp Joos, Los Maartje, Slingerland Marije, Cats Annemieke, Hospers Geke A. P., Bijlsma Maarten F., van Berge Henegouwen Mark I., Meijer Sybren L., van Laarhoven Hanneke W. M. Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab and Pertuzumab With Chemoradiotherapy for Resectable Human Epidermal Growth Factor Receptor 2-Positive Esophageal Adenocarcinoma: TRAP Study Journal of clinical oncology 2020;38 (5):462-471 [PubMed]
  • Dijk Frederike, Veenstra Veronique L., Soer Eline C., Dings Mark P. G., Zhao Lan, Halfwerk Johannes B., Hooijer Gerrit K., Damhofer Helene, Marzano Marco, Steins Anne, Waasdorp Cynthia, Busch Olivier R., Besselink Marc G., Tol Johanna A., Welling Lieke, van Rijssen Lennart B., Klompmaker Sjors, Wilmink Hanneke W., van Laarhoven Hanneke W., Medema Jan Paul, Vermeulen Louis, van Hooff Sander R., Koster Jan, Verheij Joanne, van de Vijver Marc J., Wang Xin, Bijlsma Maarten F. Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems Scientific reports 2020;10 (1):337 [PubMed]

2019

  • Lenos Kristiaan J., Lodestijn Sophie C., Lyons Scott K., Bijlsma Maarten F., Miedema Daniël M., Vermeulen Louis A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue Nature protocols 2019;14 (9):2648-2671 [PubMed]
  • Lodestijn Sophie C., Lenos Kristiaan J., Miedema Daniël M., Bijlsma Maarten F., Vermeulen Louis Cancer stem cells: here, there, and everywhere Molecular & cellular oncology 2019;6 (1):e1540235.1-e1540235.3 [PubMed]
  • Steins Anne, Ebbing Eva A., Creemers Aafke, van der Zalm Amber P., Jibodh Rajni A., Waasdorp Cynthia, Meijer Sybren L., van Delden Otto M., Krishnadath Kausilia K., Hulshof Maarten C. C. M., Bennink Roelof J., Punt Cornelis J. A., Medema Jan Paul, Bijlsma Maarten F., van Laarhoven Hanneke W. M. Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma International journal of cancer. Journal international du cancer 2019;145 (10):2792-2803 [PubMed]
  • Strijker Marin, Soer Eline C., de Pastena Matteo, Creemers Aafke, Balduzzi Alberto, Beagan Jamie J., Busch Olivier R., van Delden Otto M., Halfwerk Hans, van Hooft Jeanin E., van Lienden Krijn P., Marchegiani Giovanni, Meijer Sybren L., van Noesel Carel J., Reinten Roy J., Roos Eva, Schokker Sandor, Verheij Joanne, van de Vijver Marc J., Waasdorp Cynthia, Wilmink Johanna W., Ylstra Bauke, Besselink Marc G., Bijlsma Maarten F., Dijk Frederike, van Laarhoven Hanneke W. Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma International journal of cancer. Journal international du cancer 2019 [PubMed]
  • van Mackelenbergh Madelaine G., Stroes Charlotte I., Spijker René, van Eijck Casper H. J., Wilmink Johanna W., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Clinical trials targeting the stroma in pancreatic cancer: A systematic review and meta-analysis Cancers 2019;11 (5) [PubMed]
  • Campa Daniele, Matarazzi Martina, Greenhalf William, Bijlsma Maarten, Saum Kai-Uwe, Pasquali Claudio, van Laarhoven Hanneke, Szentesi Andrea, Federici Francesca, Vodicka Pavel, Funel Niccola, Pezzilli Raffaele, Bueno-de-Mesquita H. Bas, Vodickova Ludmila, Basso Daniela, Obazee Ofure, Hackert Thilo, Soucek Pavel, Cuk Katarina, Kaiser J. rg, Sperti Cosimo, Lovecek Martin, Capurso Gabriele, Mohelnikova-Duchonova Beatrice, Khaw Kay-Tee, König Anna-Katharina, Kupcinskas Juozas, Kaaks Rudolf, Bambi Franco, Archibugi Livia, Mambrini Andrea, Cavestro Giulia Martina, Landi Stefano, Hegyi P. ter, Izbicki Jakob R., Gioffreda Domenica, Zambon Carlo Federico, Tavano Francesca, Talar-Wojnarowska Renata, Jamroziak Krzysztof, Key Timothy J., Fave Gianfranco Delle, Strobel Oliver, Jonaitis Laimas, Andriulli Angelo, Lawlor Rita T., Pirozzi Felice, Katzke Verena, Valsuani Chiara, Vashist Yogesh K., Brenner Hermann, Canzian Federico Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study International journal of cancer. Journal international du cancer 2019;144 (6):1275-1283 [PubMed]
  • Kuninty Praneeth R., Bansal Ruchi, de Geus Susanna W. L., Mardhian Deby F., Schnittert Jonas, van Baarlen Joop, Storm Gert, Bijlsma Maarten F., van Laarhoven Hanneke W., Metselaar Josbert M., Kuppen Peter J. K., Vahrmeijer Alexander L., Östman Arne, Sier Cornelis F. M., Prakash Jai ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer Science advances 2019;5 (9) [PubMed]
  • van Hilst Jony, de Rooij Thijs, Bosscha Koop, Brinkman David J., van Dieren Susan, Dijkgraaf Marcel G., Gerhards Michael F., de Hingh Ignace H., Karsten Tom M., Lips Daniel J., Luyer Misha D., Busch Olivier R., Festen Sebastiaan, Besselink Marc G., Marsman Hendrik A., van Gulik Thomas M., Wicherts Dennis A., Eshuis Wietse J., Stibbe Luna A., Nieveen van Dijkum Els J. M., van Hooft Janine E., Fockens Paul, van Laarhoven Hanneke W., Wilmink Johanna W., van de Vijver Marcel J., Bijlsma Maarten F., Verheij Joanne, Nio C. Yung, van Lienden Krijn P., van Tienhoven Geertjan, Schoorlemmer Annuska, Creemers Geert-Jan, van Eijck Casper H. J., Groot Koerkamp Bas, Bruno Marco J., Eskens Ferry, Nuyttens Joost J., Pek Chulja, van der Schelling George P., Swijnenburg Rutger J., Brosens Lodewijk A., Roos Daphne, van Santvoort Hjalmar C., Haj Mohammad Nadia, Daams Freek, van Rijssen L. Bengt, van Veldhuisen Eran, Scholten Lianne, Strijker Marin, Korrel Maarten Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial lancet. Gastroenterology & hepatology 2019;4 (3):199-207 [PubMed]
  • Zhao Lan, Lee Victor H. F., Ng Michael K., Yan Hong, Bijlsma Maarten F. Molecular subtyping of cancer: current status and moving toward clinical applications Briefings in bioinformatics 2019;20 (2):572-584 [PubMed]
  • Schokker Sandor, van der Woude Stephanie O., van Kleef Jessy Joy, van Zoen Daan J., van Oijen Martijn G. H., Mearadji Banafsche, Beenen Ludo F. M., Stroes Charlotte I., Waasdorp Cynthia, Jibodh R. Aarti, Creemers Aafke, Meijer Sybren L., Hooijer Gerrit K. J., Punt Cornelis J. A., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Phase I Dose escalation study with expansion cohort of the addition of nab-paclitaxel to capecitabine and oxaliplatin (CapOx) as first-line treatment of metastatic esophagogastric adenocarcinoma (ACTION study) Cancers 2019;11 (6) [PubMed]
  • Spek C. A., Tekin C., Bijlsma M. F. Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice: comment Journal of thrombosis and haemostasis 2019;17 (1):235-238 [PubMed]
  • le Large Tessa Ya Sung, el Hassouni Btissame, Funel Niccola, Kok Bart, Piersma Sander R., Pham Thang V., Olive Kenneth P., Kazemier Geert, van Laarhoven Hanneke W. M., Jimenez Connie R., Bijlsma Maarten F., Giovannetti Elisa Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment Therapeutic advances in medical oncology 2019;11 [PubMed]
  • Steins Anne, Klaassen Remy, Jacobs Igor, Schabel Matthias C., van Lier Monique G. J. T. B., Ebbing Eva A., Hectors Stefanie J., Tas Sander W., Maracle Chrissta X., Punt Cornelis J. A., Siebes Maria, Bergman Jacques J. G. H. M., Medema Jan Paul, Wilmink Johanna W., Mathot Ron A. A., Strijkers Gustav J., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Rapid stromal remodeling by short-term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma Molecular oncology 2019 [PubMed]
  • Faria Alessandra V. De S., Akyala Adamu Ishaku, Parikh Kaushal, Brüggemann Lois W., Spek C. Arnold, Cao Wanlu, Bruno Marco J., Bijlsma Maarten F., Fuhler Gwenny M., Peppelenbosch Maikel P. Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling Journal of biological chemistry 2019;294 (25):9787-9798 [PubMed]
  • van der Heijden Maartje, Miedema Daniël M., Waclaw Bartlomiej, Veenstra Veronique L., Lecca Maria C., Nijman Lisanne E., van Dijk Erik, van Neerven Sanne M., Lodestijn Sophie C., Lenos Kristiaan J., de Groot Nina E., Prasetyanti Pramudita R., Varea Andrea Arricibita, Winton Douglas J., Medema Jan Paul, Morrissey Edward, Ylstra Bauke, Nowak Martin A., Bijlsma Maarten F., Vermeulen Louis Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts Proceedings of the National Academy of Sciences of the United States of America 2019;116 (13):6140-6145 [PubMed]
  • Ebbing Eva A., van der Zalm Amber P., Steins Anne, Creemers Aafke, Hermsen Simone, Rentenaar Rosa, Klein Michelle, Waasdorp Cynthia, Hooijer Gerrit K. J., Meijer Sybren L., Krishnadath Kausilia K., Punt Cornelis J. A., van Berge Henegouwen Mark I., Gisbertz Suzanne S., van Delden Otto M., Hulshof Maarten C. C. M., Medema Jan Paul, van Laarhoven Hanneke W. M., Bijlsma Maarten F. Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma Proceedings of the National Academy of Sciences of the United States of America 2019;116 (6):2237-2242 [PubMed]

2018

  • Veenstra V. L., Damhofer H., Waasdorp C., van Rijssen L. B., van de Vijver M. J., Dijk F., Wilmink H. W., Besselink M. G., Busch O. R., Chang D. K., Bailey P. J., Biankin A. V., Kocher H. M., Medema J. P., Li J. S., Jiang R., Pierce D. W., van Laarhoven H. W. M., Bijlsma M. F. ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy Oncogenesis 2018;7 (11) [PubMed]
  • Creemers Aafke, Ebbing Eva A., Pelgrim Thomas C., Lagarde Sjoerd M., van Etten-Jamaludin Faridi S., van Berge Henegouwen Mark I., Hulshof Maarten C. C. M., Krishnadath Kausilia K., Meijer Sybren L., Bijlsma Maarten F., van Oijen Martijn G. H., van Laarhoven Hanneke W. M. A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas Scientific reports 2018;8 (1) [PubMed]
  • Wils Leon J., Bijlsma Maarten F. Epigenetic regulation of the Hedgehog and Wnt pathways in cancer Critical reviews in oncology/hematology 2018;121:23-44 [PubMed]
  • Veenstra Veronique L., Garcia-Garijo Andrea, van Laarhoven Hanneke W., Bijlsma Maarten F. Extracellular Influences: Molecular Subclasses and the Microenvironment in Pancreatic Cancer Cancers 2018;10 (2):E34 [PubMed]
  • Veenstra Veronique L. Molecular understanding of Hedgehog-dependent cancers: From pathways to patients 2018. 245p. ISBN 9789463800686. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Laarhoven H. W. M. , Medema J. P.; Co-supervisor: Bijlsma M. F.)
  • le Large Tessa Ya Sung, el Hassouni Btissame, Kazemier Geert, Piersma Sander R., van Laarhoven Hanneke W. M., Bijlsma Maarten F., Jimenez Cornelia R., Giovannetti Elisa Multidrug-resistant transporter expression does not always result in drug resistance Cancer science 2018;109 (10):3360-3362 [PubMed]
  • Tekin Cansu, Shi Kun, Daalhuisen Joost B., Brink Marieke S. Ten, Bijlsma Maarten F., Spek C. Arnold PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer Oncotarget 2018;9 (62):32010-32023 [PubMed]
  • Veenstra Veronique L., Dingjan Ilse, Waasdorp Cynthia, Damhofer Helene, van der Wal Allard C., van Laarhoven Hanneke W., Medema Jan Paul, Bijlsma Maarten F. Patched-2 functions to limit Patched-1 deficient skin cancer growth Cellular oncology 2018;41 (4):427-437 [PubMed]
  • Lenos Kristiaan J., Miedema Daniël M., Lodestijn Sophie C., Nijman Lisanne E., van den Bosch Tom, Romero Ros Xavier, Lourenço Filipe C., Lecca Maria C., van der Heijden Maartje, van Neerven Sanne M., van Oort Anita, Leveille Nicolas, Adam Ronja S., de Sousa e Melo Felipe, Otten Joy, Veerman Patrick, Hypolite Guillaume, Koens Lianne, Lyons Scott K., Stassi Giorgio, Winton Douglas J., Medema Jan Paul, Morrissey Edward, Bijlsma Maarten F., Vermeulen Louis Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer Nature cell biology 2018;20 (10):1193-1202 [PubMed]
  • van der Horst Astrid, Versteijne Eva, Besselink Marc G. H., Daams Joost G., Bulle Esther B., Bijlsma Maarten F., Wilmink Johanna W., van Delden Otto M., van Hooft Jeanin E., Franken Nicolaas A. P., van Laarhoven Hanneke W. M., Crezee Johannes, van Tienhoven Geertjan The clinical benefit of hyperthermia in pancreatic cancer: a systematic review International journal of hyperthermia 2018;34 (7):969-979 [PubMed]
  • Strijker Marin, Gerritsen Arja, van Hilst Jony, Bijlsma Maarten F., Bonsing Bert A., Brosens Lodewijk A., Bruno Marco J., van Dam Ronald M., Dijk Frederike, van Eijck Casper H., Farina Sarasqueta Arantza, Fockens Paul, Gerhards Michael F., Groot Koerkamp Bas, van der Harst Erwin, de Hingh Ignace H., van Hooft Jeanin E., Huysentruyt Clément J., Kazemier Geert, Klaase Joost M., van Laarhoven Cornelis J., van Laarhoven Hanneke W., Liem Mike S., de Meijer Vincent E., van Rijssen L. Bengt, van Santvoort Hjalmar C., Suker Mustafa, Verhagen Judith H., Verheij Joanne, Verspaget Hein W., Wennink Roos A., Wilmink Johanna W., Molenaar I. Quintus, Boermeester Marja A., Busch Olivier R., Besselink Marc G. The Dutch Pancreas Biobank within the Parelsnoer Institute: A nationwide Biobank of pancreatic and periampullary diseases Pancreas 2018;47 (4):495-501 [PubMed]
  • Creemers Aafke, Ebbing Eva A., Hooijer Gerrit K. J., Stap Lisanne, Jibodh-Mulder Rajni A., Gisbertz Susanne S., Henegouwen Mark I. van Berge, van Montfoort Maurits L., Hulshof Maarten C. C. M., Krishnadath Kausilia K., van Oijen Martijn G. H., Bijlsma Maarten F., Meijer Sybren L., van Laarhoven Hanneke W. M. The dynamics of HER2 status in esophageal adenocarcinoma Oncotarget 2018;9 (42):26787-26799 [PubMed]
  • Houg Demi S., Bijlsma Maarten F. The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma Molecular cancer 2018;17 (1) [PubMed]
  • Ebbing Eva A. What tumor cells cannot resist: Mechanisms of therapy resistance in esophageal adenocarcinoma 2018. ISBN 9789462958739. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Laarhoven H. W. M., Medema J. P.; Co-supervisors: Bijlsma M. F., Punt C. J. A.)

2017

  • Creemers A., Krausz S., Strijker M., van der Wel M. J., Soer E. C., Reinten R. J., Besselink M. G., Wilmink J. W., van de Vijver M. J., van Noesel C. J. M., Verheij J., Meijer S. L., Dijk F., Bijlsma M. F., van Oijen M. G. H., van Laarhoven H. W. M. Clinical value of ctDNA in upper-GI cancers: A systematic review and meta-analysis BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 2017;1868 (2):394-403 [PubMed]
  • Creemers A., ter Veer E., de Waal L., Lodder P., Hooijer G. K. J., van Grieken N. C. T., Bijlsma M. F., Meijer S. L., van Oijen M. G. H., van Laarhoven H. W. M. Discordance in HER2 Status in Gastro-esophageal Adenocarcinomas: A Systematic Review and Meta-analysis Scientific reports 2017;7 (1):3135 [PubMed]
  • Ebbing Eva A., Steins Anne, Fessler Evelyn, Stathi Phylicia, Lesterhuis Willem Joost, Krishnadath Kausilia K., Vermeulen Louis, Medema Jan Paul, Bijlsma Maarten F., van Laarhoven Hanneke W. M. Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition Gastroenterology 2017;153 (1):63-76.e14 [PubMed]
  • Le Large T. Y. S., Bijlsma M. F., Kazemier G., van Laarhoven H. W. M., Giovannetti E., Jimenez C. R. Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies Seminars in cancer biology 2017;44:153-169 [PubMed]
  • Bijlsma Maarten F., Sadanandam Anguraj, Tan Patrick, Vermeulen Louis Molecular subtypes in cancers of the gastrointestinal tract Nature reviews. Gastroenterology & hepatology 2017;14 (6):333-342 [PubMed]
  • Bijlsma Maarten F., Roelink Henk Skin-Derived Vitamin D-3 Protects against Basal Cell Carcinoma Journal of investigative dermatology 2017;137 (12):2469-2471 [PubMed]
  • Veenstra Veronique L., Damhofer Helene, Waasdorp Cynthia, Steins Anne, Kocher Hemant M., Medema Jan P., van Laarhoven Hanneke W., Bijlsma Maarten F. Stromal SPOCK1 supports invasive pancreatic cancer growth Molecular oncology 2017;11 (8):1050-1064 [PubMed]
  • Steins Anne, Ebbing Eva A., Pistorius Marcel C. M., Waasdorp Cynthia, Krishnadath Kausilia K., Medema Jan Paul, Wilmink Johanna W., Mathôt Ron A. A., Bijlsma Maarten F., van Laarhoven Hanneke W. M. Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel Drug delivery 2017;24 (1):1801-1810 [PubMed]

2016

  • Ebbing Eva A., Medema Jan Paul, Damhofer Helene, Meijer Sybren L., Krishnadath Kausilia K., van Berge Henegouwen Mark I., Bijlsma Maarten F., van Laarhoven Hanneke W. M. ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3 Oncotarget 2016;7 (9):10243-10254 [PubMed]
  • Mariani Laura E., Bijlsma Maarten F., Ivanova Anna I., Suciu Sarah K., Kahn Richard A., Caspary Tamara Arl13b regulates Shh signaling from both inside and outside the cilium Molecular biology of the cell 2016;27 (23):3780-3790 [PubMed]
  • van Neerven Sanne M., Tieken Mathijs, Vermeulen Louis, Bijlsma Maarten F. Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity Molecular & cellular oncology 2016;3 (2):UNSP e1098791 [PubMed]
  • Le Large Tessa Y. S., Mato Prado Mireia, Krell Jonathan, Bijlsma Maarten F., Meijer Laura L., Kazemier Geert, Frampton Adam E., Giovannetti Elisa Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment Expert review of molecular diagnostics 2016;16 (7):733-736 [PubMed]
  • Creemers A., Ebbing E. A., Hooijer G. K. J., Jibodh-Mulder A. R. A., Gisbertz S. S., van Oijen M. G. H., Henegouwen M. Ivan Berge, Bijlsma M. F., Meijer S. L., van Laarhoven H. W. M. Dynamics of the HER2 receptor in esophageal adenocarcinoma: New opportunities for targeted therapy Annals of oncology 2016;27:vi227
  • Zhang Mingfeng, Wang Zhaoming, Obazee Ofure, Jia Jinping, Childs Erica J., Hoskins Jason, Figlioli Gisella, Mocci Evelina, Collins Irene, Chung Charles C., Hautman Christopher, Arslan Alan A., Beane-Freeman Laura, Bracci Paige M., Buring Julie, Duell Eric J., Gallinger Steven, Giles Graham G., Goodman Gary E., Goodman Phyllis J., Kamineni Aruna, Kolonel Laurence N., Kulke Matthew H., Malats Núria, Olson Sara H., Sesso Howard D., Visvanathan Kala, White Emily, Zheng Wei, Abnet Christian C., Albanes Demetrius, Andreotti Gabriella, Brais Lauren, Bueno-de-Mesquita H. Bas, Basso Daniela, Berndt Sonja I., Boutron-Ruault Marie-Christine, Bijlsma Maarten F., Brenner Hermann, Burdette Laurie, Campa Daniele, Caporaso Neil E., Capurso Gabriele, Cavestro Giulia Martina, Cotterchio Michelle, Costello Eithne, Elena Joanne, Boggi Ugo, Gaziano J. Michael, Gazouli Maria, Giovannucci Edward L., Goggins Michael, Gross Myron, Haiman Christopher A., Hassan Manal, Helzlsouer Kathy J., Hu Nan, Hunter David J., Iskierka-Jazdzewska Elzbieta, Jenab Mazda, Kaaks Rudolf, Key Timothy J., Khaw Kay-Tee, Klein Eric A., Kogevinas Manolis, Krogh Vittorio, Kupcinskas Juozas, Kurtz Robert C., Landi Maria T., Landi Stefano, Le Marchand Loic, Mambrini Andrea, Mannisto Satu, Milne Roger L., Neale Rachel E., Oberg Ann L., Panico Salvatore, Patel Alpa V., Peeters Petra H. M., Peters Ulrike, Pezzilli Raffaele, Porta Miquel, Purdue Mark, Quiros J. Ramón, Riboli Elio, Rothman Nathaniel, Scarpa Aldo, Scelo Ghislaine, Shu Xiao-Ou, Silverman Debra T., Soucek Pavel, Strobel Oliver, Sund Malin, Małecka-Panas Ewa, Taylor Philip R., Tavano Francesca, Travis Ruth C., Thornquist Mark, Tjønneland Anne, Tobias Geoffrey S., Trichopoulos Dimitrios, Vashist Yogesh, Vodicka Pavel, Wactawski-Wende Jean, Wentzensen Nicolas, Yu Herbert, Yu Kai, Zeleniuch-Jacquotte Anne, Kooperberg Charles, Risch Harvey A., Jacobs Eric J., Li Donghui, Fuchs Charles, Hoover Robert, Hartge Patricia, Chanock Stephen J., Petersen Gloria M., Stolzenberg-Solomon Rachael S., Wolpin Brian M., Kraft Peter, Klein Alison P., Canzian Federico, Amundadottir Laufey T. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21 Oncotarget 2016;7 (41):66328-66343 [PubMed]

2015

  • Rosati Alessandra, Basile Anna, D'Auria Raffaella, d'Avenia Morena, de Marco Margot, Falco Antonia, Festa Michelina, Guerriero Luana, Iorio Vittoria, Parente Roberto, Pascale Maria, Marzullo Liberato, Franco Renato, Arra Claudio, Barbieri Antonio, Rea Domenica, Menichini Giulio, Hahne Michael, Bijlsma Maarten, Barcaroli Daniela, Sala Gianluca, di Mola Fabio Francesco, di Sebastiano Pierluigi, Todoric Jelena, Antonucci Laura, Corvest Vincent, Jawhari Anass, Firpo Matthew A., Tuveson David A., Capunzo Mario, Karin Michael, de Laurenzi Vincenzo, Turco Maria Caterina BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages Nature communications 2015;6:8695 [PubMed]
  • Damhofer Helene, Veenstra Veronique L., Tol Johanna A. M. G., van Laarhoven Hanneke W. M., Medema Jan Paul, Bijlsma Maarten F. Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency Journal of cell science 2015;128 (1):129-139 [PubMed]
  • Childs Erica J., Mocci Evelina, Campa Daniele, Bracci Paige M., Gallinger Steven, Goggins Michael, Li Donghui, Neale Rachel E., Olson Sara H., Scelo Ghislaine, Amundadottir Laufey T., Bamlet William R., Bijlsma Maarten F., Blackford Amanda, Borges Michael, Brennan Paul, Brenner Hermann, Bueno-de-Mesquita H. Bas, Canzian Federico, Capurso Gabriele, Cavestro Giulia M., Chaffee Kari G., Chanock Stephen J., Cleary Sean P., Cotterchio Michelle, Foretova Lenka, Fuchs Charles, Funel Niccola, Gazouli Maria, Hassan Manal, Herman Joseph M., Holcatova Ivana, Holly Elizabeth A., Hoover Robert N., Hung Rayjean J., Janout Vladimir, Key Timothy J., Kupcinskas Juozas, Kurtz Robert C., Landi Stefano, Lu Lingeng, Malecka-Panas Ewa, Mambrini Andrea, Mohelnikova-Duchonova Beatrice, Neoptolemos John P., Oberg Ann L., Orlow Irene, Pasquali Claudio, Pezzilli Raffaele, Rizzato Cosmeri, Saldia Amethyst, Scarpa Aldo, Stolzenberg-Solomon Rachael Z., Strobel Oliver, Tavano Francesca, Vashist Yogesh K., Vodicka Pavel, Wolpin Brian M., Yu Herbert, Petersen Gloria M., Risch Harvey A., Klein Alison P. Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer Nature genetics 2015;47 (8):911-916 [PubMed]
  • Damhofer Helene, Ebbing Eva A., Steins Anne, Welling Lieke, Tol Johanna A., Krishnadath Kausilia K., van Leusden Tom, van de Vijver Marc J., Besselink Marc G., Busch Olivier R., van Berge Henegouwen Mark I., van Delden Otto, Meijer Sybren L., Dijk Frederike, Medema Jan Paul, van Laarhoven Hanneke W., Bijlsma Maarten F. Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract Journal of translational medicine 2015;13 (1):115 [PubMed]
  • Klaassen Remy, Bennink Roelof J., van Tienhoven Geertjan, Bijlsma Maarten F., Besselink Marc G. H., van Berge Henegouwen Mark I., Wilmink Johanna W., Nederveen Aart J., Windhorst Albert D., Hulshof Maarten C. C. M., van Laarhoven Hanneke W. M. Feasibility and repeatability of PET with the hypoxia tracer [(18)F]HX4 in oesophageal and pancreatic cancer Radiotherapy and oncology 2015;116 (1):94-99 [PubMed]
  • Damhofer Helene Opening new doors: Hedgehog signaling and the pancreatic cancer stroma 2015. 191p. ISBN 9789461825452. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Medema J. P.; Co-supervisor: Bijlsma M. F.)
  • Bijlsma Maarten F., van Laarhoven Hanneke W. M. The conflicting roles of tumor stroma in pancreatic cancer and their contribution to the failure of clinical trials: a systematic review and critical appraisal Cancer metastasis reviews 2015;34 (1):97-114 [PubMed]

2014

  • Alfaro Astrid C., Roberts Brock, Kwong Lina, Bijlsma Maarten F., Roelink Henk Ptch2 mediates the Shh response in Ptch1(-/-) cells Development (Cambridge, England) 2014;141 (17):3331-3339 [PubMed]
  • Kwong Lina, Bijlsma Maarten F., Roelink Henk Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling Nature communications 2014;5:4849 [PubMed]

2013

  • Damhofer Helene, Medema Jan Paul, Veenstra Veronique L., Badea Liviu, Popescu Irinel, Roelink Henk, Bijlsma Maarten F. Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma Molecular oncology 2013;7 (6):1031-1042 [PubMed]
  • de Sousa E Melo Felipe, Wang Xin, Jansen Marnix, Fessler Evelyn, Trinh Anne, de Rooij Laura P. M. H., de Jong Joan H., de Boer Onno J., van Leersum Ronald, Bijlsma Maarten F., Rodermond Hans, van der Heijden Maartje, van Noesel Carel J. M., Tuynman Jurriaan B., Dekker Evelien, Markowetz Florian, Medema Jan Paul, Vermeulen Louis Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions Nature medicine 2013;19 (5):614-618 [PubMed]

2012

  • Hindriksen Sanne, Bijlsma Maarten F. Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors Cancers 2012;4 (4):989-1035 [PubMed]
  • Queiroz Karla C. S., Bijlsma Maarten F., Tio René A., Zeebregts Clark J., Dunaeva Marina, Ferreira Carmen V., Fuhler Gwenny M., Kuipers Ernst J., Alves Maria M., Rezaee Farhad, Spek C. Arnold, Peppelenbosch Maikel P. Dichotomy in Hedgehog Signaling between Human Healthy Vessel and Atherosclerotic Plaques Molecular medicine (Cambridge, Mass.) 2012;18 (7):1122-1127 [PubMed]
  • Bijlsma Maarten F., Damhofer Helene, Roelink Henk Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium Science signaling 2012;5 (238):ra60 [PubMed]

2010

  • Brüggemann Lois W., Queiroz Karla C. S., Zamani Khatera, van Straaten Amber, Spek C. Arnold, Bijlsma Maarten F. Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer Cancer biology & therapy 2010;10 (1):79-88 [PubMed]
  • Spek C. Arnold, Bijlsma Maarten F., Queiroz Karla C. S. Canonical Hedgehog signaling drives proangiogenic responses in endothelial cells Cell cycle (Georgetown, Tex.) 2010;9 (9):1683 [PubMed]
  • Queiroz Karla C. S., Tio René, Zeebregts Clark, Bijlsma Maarten F., Zijlstra Felix, Badlou Bahram, de Vries Marcel, Ferreira Carmen V., Spek C. Arnold, Peppelenbosch Maikel P., Rezaee Farhad Human Plasma Very Low Density Lipoprotein Carries Indian Hedgehog Journal of proteome research 2010;9 (11):6052-6059 [PubMed]
  • Bijlsma Maarten F., Roelink Henk Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets Expert opinion on therapeutic targets 2010;14 (7):693-702 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold The Hedgehog morphogen in myocardial ischemia-reperfusion injury Experimental biology and medicine (Maywood, N.J.) 2010;235 (4):447-454 [PubMed]

2009

  • Borensztajn Keren, Bijlsma Maarten F., Reitsma Pieter H., Peppelenbosch Maikel P., Spek C. Arnold Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation Thrombosis research 2009;124 (2):219-225 [PubMed]
  • Bijlsma Maarten F., Groot Angelique P., Oduro Jeremiah P., Franken Rutger J., Schoenmakers Saskia H. H. F., Peppelenbosch Maikel P., Spek C. Arnold Hypoxia induces a hedgehog response mediated by HIF-1alpha Journal of cellular and molecular medicine 2009;13 (8B):2053-2060 [PubMed]
  • Hovius Joppe W. R., Bijlsma Maarten F., van der Windt Gerritje J. W., Wiersinga W. Joost, Boukens Bastiaan J. D., Coumou Jeroen, Oei Anneke, de Beer Regina, de Vos Alex F., van 't Veer Cornelis, van Dam Alje P., Wang Penghua, Fikrig Erol, Levi Marcel M., Roelofs Joris J. T. H., van der Poll Tom The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi PLoS pathogens 2009;5 (5):e1000447 [PubMed]

2008

  • Bijlsma Maarten F., Leenders Peter J. A., Janssen Ben J. A., Peppelenbosch Maikel P., ten Cate Hugo, Spek C. Arnold Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury Experimental biology and medicine (Maywood, N.J.) 2008;233 (8):989-996 [PubMed]
  • Lipinski Robert J., Bijlsma Maarten F., Gipp Jerry J., Podhaizer David J., Bushman Wade Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines BMC cell biology 2008;9:49 [PubMed]
  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold, Roelink Henk Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation Stem cells (Dayton, Ohio) 2008;26 (5):1138-1145 [PubMed]
  • Bijlsma Maarten Fokke Novel mechanism and functions for hedgehog signaling in development and disease 2008. 107p. ISBN 9789064642821. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Peppelenbosch M. P.; Co-supervisor: Spek C. A.)
  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold (Pro-)vitamin D as treatment option for hedgehog-related malignancies Medical hypotheses 2008;70 (1):202-203 [PubMed]

2007

  • Borensztajn Keren S., Bijlsma Maarten F., Groot Angelique P., Bruggemann Lois W., Versteeg Henri H., Reitsma Pieter H., Peppelenbosch Maikel P., Spek C. Arnold Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation Experimental cell research 2007;313 (12):2622-2633 [PubMed]
  • Slofstra Sjoukje H., Bijlsma Maarten F., Groot Angelique P., Reitsma Pieter H., Lindhout Theo, ten Cate Hugo, Spek C. Arnold Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation Blood 2007;110 (9):3176-3182 [PubMed]
  • Bijlsma Maarten F., Borensztajn Keren S., Roelink Henk, Peppelenbosch Maikel P., Spek C. Arnold Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites Cellular signalling 2007;19 (12):2596-2604 [PubMed]

2006

  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling? Development (Cambridge, England) 2006;133 (20):3951; author reply 3952-3951; author reply 3953 [PubMed]
  • Bijlsma Maarten F., Peppelenbosch Maikel P., Spek C. Arnold Hedgehog morphogen in cardiovascular disease Circulation 2006;114 (18):1985-1991 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold, Peppelenbosch Maikel P. Hedgehog turns lipoproteins into Janus-faced particles Trends in cardiovascular medicine 2006;16 (7):217-220 [PubMed]
  • Bijlsma Maarten F., Spek C. Arnold, Zivkovic Danica, van de Water Sandra, Rezaee Farhad, Peppelenbosch Maikel P. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion PLoS biology 2006;4 (8):e232-1410 [PubMed]

2005

  • de Jonge Wouter J., van der Zanden Esmerij P., The Frans O., Bijlsma Maarten F., van Westerloo David J., Bennink Roelof J., Berthoud Hans-Rudolf, Uematsu Satoshi, Akira Shizuo, van den Wijngaard Rene M., Boeckxstaens Guy E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway Nature immunology 2005;6 (8):844-851 [PubMed]
  • de Jonge W. J., van der Zanden E. P., O The F., Bijlsma M. F., van Westerloo D. J., Bennink R. J., Berthoud H. R., Uematsu S., Akira S., van den Wijngaard R. M., Boeckxstaens G. E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway (vol 6, pg 844, 2005) Nature immunology 2005;6 (9):954

2004

  • Bijlsma Maarten F., Spek C. Arnold, Peppelenbosch Maikel P. Hedgehog: an unusual signal transducer BioEssays 2004;26 (4):387-394 [PubMed]