R.J. van Holst PhD publications

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Publications PhD R.J. van Holst

Position
Associate Professor
Main activities
Research
Specialisation
pathological gambling, alcohol dependence, functional MRI, neuropsychology
Focus of research

Throughout my career, I pursued a clear line of research that focused on understanding why people make unfortunate decisions and display harmful behaviours, and importantly, why don’t they stop?! My Ph.D. elucidated specific neurobiological characteristics of pathological gambling and its similarities and differences with alcohol dependence. Directly after obtaining my Ph.D. I received an ECNP Research Grant, enabling me to focus on the neural correlates of risky decision-making at the University of Cambridge. With my NWO Rubicon fellowship grant, I focused on elucidating the role of dopamine in pathological gambling using PET scans at the Donders Institute.

Since dysfunctional decision-making and dopamine functioning underlie more psychiatric disorders than pathological gambling alone, I am intrigued to find the common denominator across psychiatric disorders. Therefore, I expanded my research to also include game addiction, obsessive-compulsive disorder, and obesity, for which I collaborated with different international research groups. To better understand food-related motivational processes I currently collaborate on a translational study using optogenetics in mice.

With a personal ABC-talent grant in 2014, I moved to the AMC to study the neural fundaments of confidence estimation in compulsive behaviour and be co-promotor of two Ph.D. students investigating habitual behaviour and the effect of non-invasive brain stimulation in addiction. In the coming years, I will use a variety of neuroimaging techniques (fMRI/PET), brain-activity modulators (rTMS/pharmaca) and approaches (network/DSM/transdiagnostic) to psychiatry with the aim to contribute to the understanding of the neural fundamentals of psychiatric disorders, especially of disorders in which people display faulty decision-making.

Amsterdam UMC Research Institutes
AMC departments
All publications

2021

  • Cao Zhipeng, Ottino-Gonzalez Jonatan, Cupertino Renata B., Schwab Nathan, Hoke Colin, Catherine Orr, Cousijn Janna, Dagher Alain, Foxe John J., Goudriaan Anna E., Hester Robert, Hutchison Kent, Li Chiang-Shan R., London Edythe D., Lorenzetti Valentina, Luijten Maartje, Martin-Santos Rocio, Momenan Reza, Paulus Martin P., Schmaal Lianne, Sinha Rajita, Sjoerds Zsuzsika, Solowij Nadia, Stein Dan J., Stein Elliot A., Uhlmann Anne, van Holst Ruth J., Veltman Dick J., Wiers Reinout W., Yücel Murat, Zhang Sheng, Jahanshad Neda, Thompson Paul M., Conrod Patricia, Mackey Scott, Garavan Hugh Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group Addiction biology 2021 [PubMed]

2020

  • Navarri Xavier, Afzali Mohammad H., Lavoie Jacob, Sinha Rajita, Stein Dan J., Momenan Reza, Veltman Dick J., Korucuoglu Ozlem, Sjoerds Zsuzsika, van Holst Ruth J., Hester Rob, Orr Catherine, Cousijn Janna, Yucel Murat, Lorenzetti Valentina, Wiers Reinout, Jahanshad Neda, Glahn David C., Thompson Paul M., Mackey Scott, Conrod Patricia J. How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings Human brain mapping 2020 [PubMed]
  • van Timmeren Tim, Quail Stephanie L., Balleine Bernard W., Geurts Dirk E. M., Goudriaan Anna E., van Holst Ruth J. Intact corticostriatal control of goal-directed action in Alcohol Use Disorder: a Pavlovian-to-instrumental transfer and outcome-devaluation study Scientific reports 2020;10 (1) [PubMed]
  • Perales José C., King Daniel L., Navas Juan F., Schimmenti Adriano, Sescousse Guillaume, Starcevic Vladan, van Holst Ruth J., Billieux Joël Learning to lose control: A process-based account of behavioral addiction Neuroscience and biobehavioral reviews 2020;108:771-780 [PubMed]
  • Hahn Sage, Mackey Scott, Cousijn Janna, Foxe John J., Heinz Andreas, Hester Robert, Hutchinson Kent, Kiefer Falk, Korucuoglu Ozlem, Lett Tristram, Li Chiang-Shan R., London Edythe, Lorenzetti Valentina, Maartje Luijten, Momenan Reza, Orr Catherine, Paulus Martin, Schmaal Lianne, Sinha Rajita, Sjoerds Zsuzsika, Stein Dan J., Stein Elliot, van Holst Ruth J., Veltman Dick, Walter Henrik, Wiers Reinout W., Yucel Murat, Thompson Paul M., Conrod Patricia, Allgaier Nicholas, Garavan Hugh Predicting alcohol dependence from multi-site brain structural measures Human brain mapping 2020 [PubMed]
  • Schluter Renee S. Stimulation of the addicted brain: Magnetic stimulation as add-on treatment for alcohol use disorder 2020. 295p. ISBN 9789402820256. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Goudriaan Anna E.; Co-supervisor: van Holst Ruth J.)
  • Chye Yann, Mackey Scott, Gutman Boris A., Ching Christopher R. K., Batalla Albert, Blaine Sara, Brooks Samantha, Caparelli Elisabeth C., Cousijn Janna, Dagher Alain, Foxe John J., Goudriaan Anna E., Hester Robert, Hutchison Kent, Jahanshad Neda, Kaag Anne M., Korucuoglu Ozlem, Li Chiang-Shan R., London Edythe D., Lorenzetti Valentina, Luijten Maartje, Martin-Santos Rocio, Meda Shashwath A., Momenan Reza, Morales Angelica, Orr Catherine, Paulus Martin P., Pearlson Godfrey, Reneman Liesbeth, Schmaal Lianne, Sinha Rajita, Solowij Nadia, Stein Dan J., Stein Elliot A., Tang Deborah, Uhlmann Anne, van Holst Ruth, Veltman Dick J., Verdejo-Garcia Antonio, Wiers Reinout W., Yücel Murat, Thompson Paul M., Conrod Patricia, Garavan Hugh Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study Addiction biology 2020;25 (6) [PubMed]

2019

  • Hoven Monja, Lebreton Maël, Engelmann Jan B., Denys Damiaan, Luigjes Judy, van Holst Ruth J. Abnormalities of confidence in psychiatry: an overview and future perspectives Translational psychiatry 2019;9 (1):268 [PubMed]
  • van Timmeren Tim Addiction: A striatal roller-coaster: On the neural and associative-learning mechanisms underlying gambling and alcohol use disorder 2019. 220p. ISBN 9789463754033. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Goudriaan A. E.; Co-supervisor: van Holst R. J.)
  • Li Yansong, Wang Zixiang, Boileau Isabelle, Dreher Jean-Claude, Gelskov Sofie, Genauck Alexander, Joutsa Juho, Kaasinen Valtteri, Perales José C., Romanczuk-Seiferth Nina, Ruiz de Lara Cristian M., Siebner Hartwig R., van Holst Ruth J., van Timmeren Tim, Sescousse Guillaume Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study Translational psychiatry 2019;9 (1) [PubMed]
  • Yücel Murat, Oldenhof Erin, Ahmed Serge H., Belin David, Billieux Joel, Bowden-Jones Henrietta, Carter Adrian, Chamberlain Samuel R., Clark Luke, Connor Jason, Daglish Mark, Dom Geert, Dannon Pinhas, Duka Theodora, Fernandez-Serrano Maria Jose, Field Matt, Franken Ingmar, Goldstein Rita Z., Gonzalez Raul, Goudriaan Anna E., Grant Jon E., Gullo Matthew J., Hester Robert, Hodgins David C., le Foll Bernard, Lee Rico S. C., Lingford-Hughes Anne, Lorenzetti Valentina, Moeller Scott J., Munafò Marcus R., Odlaug Brian, Potenza Marc N., Segrave Rebecca, Sjoerds Zsuzsika, Solowij Nadia, van den Brink Wim, van Holst Ruth J., Voon Valerie, Wiers Reinout, Fontenelle Leonardo F., Verdejo-Garcia Antonio A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study Addiction (Abingdon, England) 2019;114 (6):1095-1109 [PubMed]
  • Schluter Renée S., van Holst Ruth J., Goudriaan Anna E. Effects of Ten Sessions of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) Add-on Treatment on Impulsivity in Alcohol Use Disorder Frontiers in neuroscience 2019;13 [PubMed]
  • Goudriaan Anna E., van den Brink Wim, van Holst Ruth J. Gambling disorder and substance-related disorders: Similarities and differencesin: Gambling Disorder. Springer International Publishing; 2019. p. 247-269, ISBN 9783030030582
  • Liu Yang, van den Wildenberg Wery P. M., de Graaf Ysanne, Ames Susan L., Baldacchino Alexander, Bø Ragnhild, Cadaveira Fernando, Campanella Salvatore, Christiansen Paul, Claus Eric D., Colzato Lorenza S., Filbey Francesca M., Foxe John J., Garavan Hugh, Hendershot Christian S., Hester Robert, Jester Jennifer M., Karoly Hollis C., Kräplin Anja, Kreusch Fanny, Landrø Nils Inge, Littel Marianne, Loeber Sabine, London Edythe D., López-Caneda Eduardo, Lubman Dan I., Luijten Maartje, Marczinski Cecile A., Metrik Jane, Montgomery Catharine, Papachristou Harilaos, Mi Park Su, Paz Andres L., Petit G. raldine, Prisciandaro James J., Quednow Boris B., Ray Lara A., Roberts Carl A., Roberts Gloria M. P., de Ruiter Michiel B., Rupp Claudia I., Steele Vaughn R., Sun Delin, Takagi Michael, Tapert Susan F., van Holst Ruth J., Verdejo-Garcia Antonio, Vonmoos Matthias, Wojnar Marcin, Yao Yuanwei, Yücel Murat, Zack Martin, Zucker Robert A., Huizenga Hilde M., Wiers Reinout W. Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders Neuroscience and biobehavioral reviews 2019;105:288-304 [PubMed]
  • Mackey Scott, Allgaier Nicholas, Chaarani Bader, Spechler Philip, Orr Catherine, Bunn Janice, Allen Nicholas B, Alia-Klein Nelly, Batalla Albert, Blaine Sara, Brooks Samantha, Caparelli Elisabeth, Chye Yann Ying, Cousijn Janna, Dagher Alain, Desrivieres Sylvane, Feldstein-Ewing Sarah, Foxe John J, Goldstein Rita Z, Goudriaan Anna E, Heitzeg Mary M, Hester Robert, Hutchison Kent, Korucuoglu Ozlem, Li Chiang-Shan R, London Edythe, Lorenzetti Valentina, Luijten Maartje, Martin-Santos Rocio, May April, Momenan Reza, Morales Angelica, Paulus Martin P, Pearlson Godfrey, Rousseau Marc-Etienne, Salmeron Betty Jo, Schluter Renée, Schmaal Lianne, Schumann Gunter, Sjoerds Zsuzsika, Stein Dan J, Stein Elliot A, Sinha Rajita, Solowij Nadia, Tapert Susan, Uhlmann Anne, Veltman Dick, van Holst Ruth, Whittle Sarah, Wright Margaret J, Glahn David C., Conrod Patricia, Garavan Hugh Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects American journal of psychiatry 2019;176 (2):119-128 [PubMed]
  • van Holst Ruth Janke, Janssen Lieneke K., van Mierlo Petra, Lammers Gert Jan, Cools Roshan, Overeem Sebastiaan, Aarts Esther Publisher Correction: Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1 (Scientific Reports, (2018), 8, 1, (16391), 10.1038/s41598-018-34647-6) Scientific reports 2019;9 (1):8766 [PubMed]

2018

  • van Timmeren Tim, Daams Joost G., van Holst Ruth J., Goudriaan Anna E. Compulsivity-related neurocognitive performance deficits in gambling disorder: A systematic review and meta-analysis Neuroscience and biobehavioral reviews 2018;84:204-217 [PubMed]
  • van Timmeren Tim, Zhutovsky Paul, van Holst Ruth J., Goudriaan Anna E. Connectivity networks in gambling disorder: a resting-state fMRI study International gambling studies 2018;18 (2):242-258
  • Schluter Renee S., Jansen Jochem M., van Holst Ruth J., van den Brink Wim, Goudriaan Anna E. Differential effects of left and right prefrontal high frequency rTMS on resting state fMRI in healthy individuals Brain connectivity 2018;8 (2):60-67 [PubMed]
  • Schluter Renée S., Daams Joost G., van Holst Ruth J., Goudriaan Anna E. Effects of non-invasive neuromodulation on executive and other cognitive functions in addictive disorders: A systematic review Frontiers in neuroscience 2018;12 (SEP) [PubMed]
  • van Holst Ruth Janke, Janssen Lieneke K., van Mierlo Petra, Jan Lammers Gert, Cools Roshan, Overeem Sebastiaan, Aarts Esther Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1 Scientific reports 2018;8 (1) [PubMed]
  • Yücel Murat, Carter Adrian, Harrigan Kevin, van Holst Ruth J., Livingstone Charles Hooked on gambling: a problem of human or machine design? Lancet. Psychiatry 2018;5 (1):20-21 [PubMed]
  • Maniaci G., Goudriaan A. E., Cannizzaro C., van Holst R. J. Impulsivity and Stress Response in Pathological Gamblers During the Trier Social Stress Test Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming 2018;34 (1):147-160 [PubMed]
  • van Holst Ruth J., Sescousse Guillaume, Janssen Lieneke K., Janssen Marcel, Berry Anne S., Jagust William J., Cools Roshan Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction Biological psychiatry 2018;83 (12):1036-1043 [PubMed]
  • Kong Xiang-Zhen, Mathias Samuel R., Guadalupe Tulio, Abé Christoph, Agartz Ingrid, Akudjedu Theophilus N., Aleman Andre, Alhusaini Saud, Allen Nicholas B., Ames David, Andreassen Ole A., Vasquez Alejandro Arias, Armstrong Nicola J., Bergo Felipe, Bastin Mark E., Batalla Albert, Bauer Jochen, Baune Bernhard T., Baur-Streubel Ramona, Biederman Joseph, Blaine Sara K., Boedhoe Premika, Bøen Erlend, Bose Anushree, Bralten Janita, Brandeis Daniel, Brem Silvia, Brodaty Henry, Yüksel Dilara, Brooks Samantha J., Buitelaar Jan, Bürger Christian, Bülow Robin, Calhoun Vince, Calvo Anna, Canales-Rodríguez Erick Jorge, Canive Jose M., Cannon Dara M., Goudriaan Anna E., van Holst Ruth J., Liu Jia, Oosterlaan Jaap, Schmaal Lianne, Sjoerds Zsuzsika, Goudriaan Anna E., van Holst Ruth J., Liu Jia, Oosterlaan Jaap, Schmaal Lianne, Sjoerds Zsuzsika Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium Proceedings of the National Academy of Sciences of the United States of America 2018;115 (22):E5154-E5163 [PubMed]
  • Schluter Renée S., van Holst Ruth J., Goudriaan Anna E. Repetitive transcranial magnetic stimulation (rTMS) in alcohol dependence: Study protocol of a randomized controlled clinical trial of efficacy and working mechanisms BMC psychiatry 2018;18 (1) [PubMed]
  • Sescousse Guillaume, Ligneul Romain, van Holst Ruth J., Janssen Lieneke K., de Boer Femke, Janssen Marcel, Berry Anne S., Jagust William J., Cools Roshan Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation European journal of neuroscience 2018;47 (9):1081-1086 [PubMed]
  • Lebreton Maël, Langdon Shari, Slieker Matthijs J., Nooitgedacht Jip S., Goudriaan Anna E., Denys Damiaan, van Holst Ruth J., Luigjes Judy Two sides of the same coin: Monetary incentives concurrently improve and bias confidence judgments Science advances 2018;4 (5) [PubMed]

2017

  • Maniaci Giuseppe, Picone Francesca, van Holst Ruth J., Bolloni Corinna, Scardina Silvana, Cannizzaro Carla Alterations in the Emotional Regulation Process in Gambling Addiction: The Role of Anger and Alexithymia Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming 2017;33 (2):633-647 [PubMed]
  • van Holst Ruth J., van Timmeren Tim, Goudriaan Anneke E. Are There Differences in Disruptions of Reward Processing Between Substance Use Disorder and Gambling Disorder? JAMA psychiatry 2017;74 (7):759-+ [PubMed]
  • van Timmeren Tim, Jansen Jochem M., Caan Matthan W. A., Goudriaan Anna E., van Holst Ruth J. White matter integrity between left basal ganglia and left prefrontal cortex is compromised in gambling disorder Addiction biology 2017;22 (6):1590-1600 [PubMed]

2016

  • van Holst Ruth Janke, van der Cruijsen Lisa, van Mierlo Petra, Lammers Gert Jan, Cools Roshan, Overeem Sebastiaan, Aarts Esther Aberrant Food Choices after Satiation in Human Orexin-Deficient Narcolepsy Type 1 Sleep 2016;39 (11):1951-1959 [PubMed]
  • Chamberlain Samuel R., Lochner Christine, Stein Dan J., Goudriaan Anna E., van Holst Ruth Janke, Zohar Joseph, Grant Jon E. Behavioural addiction-A rising tide? European neuropsychopharmacology 2016;26 (5):841-855 [PubMed]

2015

  • Jansen Jochem M., van Holst Ruth J., van den Brink Wim, Veltman Dick J., Caan Matthan W. A., Goudriaan Anna E. Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls Addiction biology 2015;20 (5):979-989 [PubMed]

2014

  • Vanes Lucy D., van Holst Ruth J., Jansen Jochem M., van den Brink Wim, Oosterlaan Jaap, Goudriaan Anna E. Contingency learning in alcohol dependence and pathological gambling: learning and unlearning reward contingencies Alcoholism, clinical and experimental research 2014;38 (6):1602-1610 [PubMed]
  • van Holst Ruth J., Clark Luke, Veltman Dick J., van den Brink Wim, Goudriaan Anna E. Enhanced striatal responses during expectancy coding in alcohol dependence Drug and alcohol dependence 2014;142:204-208 [PubMed]
  • Goudriaan Anna E., Yücel Murat, van Holst Ruth J. Getting a grip on problem gambling: what can neuroscience tell us? Frontiers in behavioral neuroscience 2014;8:141 [PubMed]
  • Van Holst Ruth J., Chase Henry W., Clark Luke Striatal connectivity changes following gambling wins and near-misses: Associations with gambling severity NeuroImage. Clinical 2014;5:232-239 [PubMed]

2013

  • Blanco Carlos E., Blaszczynski A., Clement R., Derevensky J., Goudriaan A. E., Hodgins D. C., van Holst R. J., Ibáñez A., Martins S. S., Moersen C., Molinaro S., Parke A., Peren F. W., Petry N. M., Wardle H. Assessment Tool to Measure and Evaluate the Risk Potential of Gambling Products, ASTERIG: A Global Validation Gaming Law Review and Economics 2013;17 (9):635-642
  • Hellman Matilda, Schoenmakers Tim M., Nordstrom Benjamin R., van Holst Ruth J. Is there such a thing as online video game addiction? A cross-disciplinary review ADDICTION RESEARCH & THEORY 2013;21 (2):102-112
  • Starcke Katrin, van Holst Ruth J., van den Brink Wim, Veltman Dick J., Goudriaan Anna E. Physiological and endocrine reactions to psychosocial stress in alcohol use disorders: duration of abstinence matters Alcoholism, clinical and experimental research 2013;37 (8):1343-1350 [PubMed]
  • Limbrick-Oldfield Eve H., Van Holst Ruth J., Clark Luke Review Article Fronto-striatal dysregulation in drug addiction and pathological gambling: Consistent inconsistencies? NeuroImage. Clinical 2013;2 (1):385-393

2012

  • van Holst Ruth J., Lemmens Jeroen S., Valkenburg Patti M., Peter Jochen, Veltman Dick J., Goudriaan Anna E. Attentional Bias and Disinhibition Toward Gaming Cues Are Related to Problem Gaming in Male Adolescents Journal of adolescent health 2012;50 (6):541-546 [PubMed]
  • van Holst Ruth J., de Ruiter Michiel B., van den Brink Wim, Veltman Dick J., Goudriaan Anna E. A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls Drug and alcohol dependence 2012;124 (1-2):142-148 [PubMed]
  • van Holst Ruth J., Veltman Dick J., Büchel Christian, van den Brink Wim, Goudriaan Anna E. Distorted Expectancy Coding in Problem Gambling: Is the Addictive in the Anticipation? Biological psychiatry 2012;71 (8):741-748 [PubMed]
  • van Holst Ruth J., van der Meer Johan N., McLaren Donald G., van den Brink Wim, Veltman Dick J., Goudriaan Anna E. Interactions between Affective and Cognitive Processing Systems in Problematic Gamblers: A Functional Connectivity Study PLoS ONE 2012;7 (11):e49923 [PubMed]
  • Goudriaan A. E., van Holst R. J., Veltman D. J., van den Brink W. Neuroscience of Pathological Gamblingin: D. Richard, A. Blaszczynski, L. Nower, editors. Handbook of Pathological Gambling. S.l.: Wiley-Blackwell; 2012.
  • van Holst Ruth J., van Holstein Mieke, van den Brink Wim, Veltman Dick J., Goudriaan Anna E. Response Inhibition during Cue Reactivity in Problem Gamblers: An fMRI Study PLoS ONE 2012;7 (3):e30909 [PubMed]
  • van Holst Ruth J., Veltman Dick J., van den Brink Wim, Goudriaan Anna E. Right on Cue? Striatal Reactivity in Problem Gamblers Biological psychiatry 2012;72 (10):E23-E24 [PubMed]
  • Van Holst Ruth J. Verwachtingen en het brein van probleemgokkers: Het spel of de knikkers? Tijdschrift voor psychiatrie 2012;54 (5):485-486

2011

  • van Holst Ruth Janke, Schilt Thelma Drug-related decrease in neuropsychological functions of abstinent drug users Current drug abuse reviews 2011;4 (1):42-56 [PubMed]
  • van Holst Ruth J. Imagingstudies in pathological gambling: similarities and differences with alcohol dependence 2011. 238p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van den Brink W., Veltman D. J.; Co-supervisor: Goudriaan A. E.)

2010

  • van Holst Ruth J., van den Brink Wim, Veltman Dick J., Goudriaan Anna E. Brain Imaging Studies in Pathological Gambling Current psychiatry reports 2010;12 (5):418-425 [PubMed]
  • van Holst Ruth J., van den Brink Wim, Veltman Dick J., Goudriaan Anna E. Why gamblers fail to win: a review of cognitive and neuroimaging findings in pathological gambling Neuroscience and biobehavioral reviews 2010;34 (1):87-107 [PubMed]
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