PhD S.A.B.M. Aarts publications

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Publications PhD S.A.B.M. Aarts

Position
Other Academic Staff
Main activities
Research
Specialisation
Immunology
Focus of research

 1. Cell-type specific actions of CD40-CD40L signaling in obesity: we generated CD40Lfl/fl and CD40fl/fl mice which are backcrossed with an array of cell-type specific Cre mice, which will give us additional information on the exact role and communication of the different CD40(L) expressing cell-types.

2. Identification of CD40-CD40L signal transduction pathways in multiple sclerosis: CD40-/- mice received a CD40 transgene with mutations in the respective TRAF-binding sites and are subjected to EAE.

2019

  • Reiche Myrthe E., den Toom Myrthe, Willemsen Lisa, van Os Bram, Gijbels Marion J. J., Gerdes Norbert, Aarts Suzanne A. B. M., Lutgens Esther Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction BMJ open diabetes research and care 2019;7 (1)
  • Aarts Suzanne, Reiche Myrthe, den Toom Myrthe, Gijbels Marion, Beckers Linda, Gerdes Norbert, Lutgens Esther Depletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH Scientific reports 2019;9 (1):14702 [PubMed]

2018

  • Aarts Suzanne A. B. M. CD40 in MS: Multiple sclerosis and the metabolic syndrome 2018. 203p. ISBN 9789463750523. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Lutgens E., de Winther M. P. J.; Co-supervisors: Kooij G., Seijkens T. T. P.)
  • Aarts Suzanne A. B. M., Reiche Myrthe E., den Toom Myrthe, Beckers Linda, Gijbels Marion J. J., Gerdes Norbert, de Winther Menno P. J., Lutgens Esther Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction PLoS ONE 2018;13 (8) [PubMed]
  • Seijkens Tom T. P., van Tiel Claudia M., Kusters Pascal J. H., Atzler Dorothee, Soehnlein Oliver, Zarzycka Barbara, Aarts Suzanne A. B. M., Lameijer Marnix, Gijbels Marion J., Beckers Linda, den Toom Myrthe, Slütter Bram, Kuiper Johan, Duchene Johan, Aslani Maria, Megens Remco T. A., van 't Veer Cornelis, Kooij Gijs, Schrijver Roy, Hoeksema Marten A., Boon Louis, Fay Francois, Tang Jun, Baxter Samantha, Jongejan Aldo, Moerland Perry D., Vriend Gert, Bleijlevens Boris, Fisher Edward A., Duivenvoorden Raphael, Gerdes Norbert, de Winther Menno P. J., Nicolaes Gerry A., Mulder Willem J. M., Weber Christian, Lutgens Esther Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis Journal of the American College of Cardiology 2018;71 (5):527-542 [PubMed]

2017

  • Aarts Suzanne A. B. M., Seijkens Tom T. P., Kusters Pascal J. H., van der Pol Susanne M. A., Zarzycka Barbara, Heijnen Priscilla D. A. M., Beckers Linda, den Toom Myrthe, Gijbels Marion J. J., Boon Louis, Weber Christian, de Vries Helga E., Nicolaes Gerry A. F., Dijkstra Christine D., Kooij Gijs, Lutgens Esther Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation Journal of neuroinflammation 2017;14 (1):105 [PubMed]
  • Aarts Suzanne A. B. M., Seijkens Tom T. P., van Dorst Koos J. F., Dijkstra Christine D., Kooij Gijs, Lutgens Esther The CD40-CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Frontiers in immunology 2017;8:1791 [PubMed]

2016

  • Braster Quinte, Silvestre-Roig Carlos, Hartwig Helene, Kusters Pascal, Aarts Suzanne, den Toom Myrthe, Gallo Richard L., Weber Christian, Lutgens Esther, Soehnlein Oliver Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity Thrombosis and haemostasis 2016;115 (6):1237-1239 [PubMed]