S.E.M. Heinsbroek PhD publications

2020

• Diederen Kay, Li Jia V., Donachie Gillian E., de Meij Tim G., de Waart Dirk R., Hakvoort Theodorus B. M., Kindermann Angelika, Wagner Josef, Auyeung Victoria, te Velde Anje A., Heinsbroek Sigrid E. M., Benninga Marc A., Kinross James, Walker Alan W., de Jonge Wouter J., Seppen Jurgen Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease Scientific reports 2020;10 (1) [PubMed]

2019

• Willemze Rose A, Welting Olaf, van Hamersveld Patricia, Verseijden Caroline, Nijhuis Laurens E, Hilbers Francisca W, Meijer Sybren L, Heesters Balthasar A, Folgering Joost H A, Darwinkel Harold, Blancou Philippe, Vervoordeldonk Margriet J, Seppen Jurgen, Heinsbroek Sigrid E M, de Jonge Wouter J Loss of intestinal sympathetic innervation elicits an innate immune driven colitis Molecular medicine (Cambridge, Mass.) 2019;25 (1):1 [PubMed]
• Botschuijver Sara, van Diest Sophie A., van Thiel Isabelle A. M., Saia Rafael S., Strik Anne S., Yu Zhumei, Maria-Ferreira Daniele, Welting Olaf, Keszthelyi Daniel, Jennings Gary, Heinsbroek Sigrid E. M., Elferink Ronald P. Oude, Schuren Frank H. J., de Jonge Wouter J., van den Wijngaard René M. Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms Scientific reports 2019;9 (1) [PubMed]

2017

• Botschuijver Sara, Roeselers Guus, Levin Evgeni, Jonkers Daisy M., Welting Olaf, Heinsbroek Sigrid E. M., de Weerd Heleen H., Boekhout Teun, Fornai Matteo, Masclee Ad A., Schuren Frank H. J., de Jonge Wouter J., Seppen Jurgen, van den Wijngaard René M. Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats Gastroenterology 2017;153 (4):1026-1039 [PubMed]

2016

• Heinsbroek S. E. M., Squadrito M. L., Schilderink R., Hilbers F. W., Verseijden C., Hofmann M., Helmke A., Boon L., Wildenberg M. E., Roelofs J. J. T. H., Ponsioen C. Y., Peters C. P., te Velde A. A., Gordon S., de Palma M., de Jonge W. J. miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation Mucosal immunology 2016;9 (4):960-973 [PubMed]

2015

• Szilagyi Katka, Gijbels Marion J. J., van der Velden Saskia, Heinsbroek Sigrid E. M., Kraal Georg, de Winther Menno P. J., van den Berg Timo K. Dectin-1 deficiency does not affect atherosclerosis development in mice Atherosclerosis 2015;239 (2):318-321 [PubMed]
• te Velde Anje A., Brüll Florence, Heinsbroek Sigrid E. M., Meijer Sybren L., Lütjohann Dieter, Vreugdenhil Anita, Plat Jogchum Effects of Dietary Plant Sterols and Stanol Esters with Low- and High-Fat Diets in Chronic and Acute Models for Experimental Colitis Nutrients 2015;7 (10):8518-8531 [PubMed]
• Heinsbroek Sigrid E. M., Williams David L., Welting Olaf, Meijer Sybren L., Gordon Siamon, de Jonge Wouter J. Orally delivered β-glucans aggravate dextran sulfate sodium (DSS)-induced intestinal inflammation Nutrition research (New York, N.Y.) 2015;35 (12):1106-1112 [PubMed]

2013

• Bernink Jochem H., Peters Charlotte P., Munneke Marius, te Velde Anje A., Meijer Sybren L., Weijer Kees, Hreggvidsdottir Hulda S., Heinsbroek Sigrid E., Legrand Nicolas, Buskens Christianne J., Bemelman Willem A., Mjösberg Jenny M., Spits Hergen Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues Nature immunology 2013;14 (3):221-229 [PubMed]

2012

• Heinsbroek Sigrid E. M., Oei Anneke, Roelofs Joris J. T. H., Dhawan Shobhit, te Velde Anje, Gordon Siamon, de Jonge Wouter J. Genetic deletion of dectin-1 does not affect the course of murine experimental colitis BMC gastroenterology 2012;12 (1):33 [PubMed]

2011

• Gazi Umut, Rosas Marcela, Singh Sonali, Heinsbroek Sigrid, Haq Imran, Johnson Simon, Brown Gordon D., Williams David L., Taylor Philip R., Martinez-Pomares Luisa Fungal recognition enhances mannose receptor shedding through dectin-1 engagement Journal of biological chemistry 2011;286 (10):7822-7829 [PubMed]

2009

• Heinsbroek Sigrid E. M., Kamen Lynn A., Taylor Philip R., Brown Gordon D., Swanson Joel, Gordon Siamon Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages Journal of innate immunity 2009;1 (3):244-253 [PubMed]
• Heinsbroek Sigrid E. M., Gordon Siamon The role of macrophages in inflammatory bowel diseases Expert reviews in molecular medicine 2009;11:e14 [PubMed]
• van der Zanden Esmerij P., Snoek Susanne A., Heinsbroek Sigrid E., Stanisor Oana I., Verseijden Caroline, Boeckxstaens Guy E., Peppelenbosch Maikel P., Greaves David R., Gordon Siamon, de Jonge Wouter J. Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2 Gastroenterology 2009;137 (3):1029-1039, 1039.e1-4 [PubMed]

2008

• Yona Simon, Lin Hsi-Hsien, Dri Pietro, Davies John Q., Hayhoe Richard P. G., Lewis Sion M., Heinsbroek Sigrid E. M., Brown K. Alun, Perretti Mauro, Hamann Jörg, Treacher David F., Gordon Siamon, Stacey Martin Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function FASEB journal 2008;22 (3):741-751 [PubMed]
• Heinsbroek Sigrid E. M., Taylor Philip R., Martinez Fernando O., Martinez-Pomares Luisa, Brown Gordon D., Gordon Siamon Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis PLoS pathogens 2008;4 (11):e1000218 [PubMed]
• del Pilar Jiménez-A M., Viriyakosol S., Walls L., Datta S. K., Kirkland T., Heinsbroek S. E. M., Brown G., Fierer J. Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a) Genes and immunity 2008;9 (4):338-348 [PubMed]

2006

• Heinsbroek Sigrid E. M., Taylor Philip R., Rosas Marcela, Willment Janet A., Williams David L., Gordon Siamon, Brown Gordon D. Expression of functionally different dectin-1 isoforms by murine macrophages Journal of immunology (Baltimore, Md. 2006;176 (9):5513-5518 [PubMed]
• Yona Simon, Heinsbroek Sigrid E. M., Peiser Leanne, Gordon Siamon, Perretti Mauro, Flower Roderick J. Impaired phagocytic mechanism in annexin 1 null macrophages British journal of pharmacology 2006;148 (4):469-477 [PubMed]

2005

• Heinsbroek Sigrid E. M., Brown Gordon D., Gordon Siamon Dectin-1 escape by fungal dimorphism Trends in immunology 2005;26 (7):352-354 [PubMed]
• Taylor Philip R., Reid Delyth M., Heinsbroek Sigrid E. M., Brown Gordon D., Gordon Siamon, Wong Simon Y. C. Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo European journal of immunology 2005;35 (7):2163-2174 [PubMed]
• Szabó Rita, Peiser Leanne, Plüddemann Annette, Bösze Szilvia, Heinsbroek Sigrid, Gordon Siamon, Hudecz Ferenc Uptake of branched polypeptides with poly[L-lys] backbone by bone-marrow culture-derived murine macrophages: the role of the class a scavenger receptor Bioconjugate chemistry 2005;16 (6):1442-1450 [PubMed]

2004

• Hobson Richard P., Munro Carol A., Bates Steven, Maccallum Donna M., Cutler Jim E., Heinsbroek Sigrid E. M., Brown Gordon D., Odds Frank C., Gow Neil A. R. Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition Journal of biological chemistry 2004;279 (38):39628-39635 [PubMed]