PhD W.J. Bakker publications

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Publications PhD W.J. Bakker

Position
Assistant Professor
Main activities
Research
Specialisation
Hypoxia / Gene expression / Cancer Biology / Tumor angiogenesis / Immunology
Focus of research

Tumor hypoxia is a hallmark of solid tumor development and an adverse prognostic factor as it promotes metastasis, as well as resistance to radio- and chemotherapy, and importantly also to immunotherapy. Tumor hypoxia, resulting from an instable and malfunctioning tumor vasculature, induces resistance to immunotherapy by promoting the formation of an immune suppressive tumor micro-environment. Recently we identified the hypoxia-induced HIF1-E2F7 transcription complex, involved in the regulation of tumor development and angiogenesis, and we are currently exploring if the hypoxia-induced immune suppressive tumor environment can by targeted through this novel complex.     

 

2019

  • Bakker Wouter J., Aufenacker Theo J., Boschman Julitta S., Burgmans Josephina P. J. Lightweight mesh is recommended in open inguinal (Lichtenstein) hernia repair: A systematic review and meta-analysis Surgery 2019 [PubMed]

2018

  • Roos M. M., Bakker W. J., Goedhart E. A., Verleisdonk E. J. M. M., Clevers G. J., Voorbrood C. E. H., Sanders F. B. M., Naafs D. B., Burgmans J. P. J. Athletes with inguinal disruption benefit from endoscopic totally extraperitoneal (TEP) repair Hernia 2018;22 (3):517-524 [PubMed]
  • Weijts B. G. M. W., Westendorp B., Hien B. T., Martínez-López L. M., Zijp M., Thurlings I., Thomas R. E., Schulte-Merker S., Bakker W. J., de Bruin A. Atypical E2Fs inhibit tumor angiogenesis Oncogene 2018;37 (2):271-276 [PubMed]
  • Roos Marleen M., Verleisdonk Egbert-Jan M. M., Sanders Floris B. M., Hoes Arno W., Stellato Rebecca K., Frederix Geert W. J., Simmermacher Rogier K. J., Burgmans Josephina P. J., van Hessen Coen V., Bakker Wouter J., Burgmans Ine P. J., van Stel Henk F., de Vries Andre, Simons Maarten P., Verheijen Paul M., Contant Caroline M. E., Wegdam Johannes A., Slooter Gerrit D., Cense Huib A., Kloppenberg Frank W. H., Roos Marleen M., van Hessen Coen V., Bakker Wouter J., Verleisdonk Egbert Jan M. M., Sanders Floris B. M., Burgmans Ine P. J., Simmermacher Rogier K. J., Hoes Arno W., Stellato Rebecca K., Frederix Geert W., van Stel Henk F., de Vries Andre, Simons Maarten P., Verheijen Paul M., Contant Caroline M. E., Wegdam Johannes A., Slooter Gerrit D., Cense Huib A., Kloppenberg Frank W. H. Effectiveness of endoscopic totally extraperitoneal (TEP) hernia correction for clinically occult inguinal hernia (EFFECT): Study protocol for a randomized controlled trial Trials 2018;19 (1) [PubMed]
  • Roos Marleen, Bakker Wouter J., Schouten Nelleke, Voorbrood Charlotte, Clevers Geert Jan, Verleisdonk Egbert Jan, Davids Paul, Burgmans Josephina Higher Recurrence Rate After Endoscopic Totally Extraperitoneal (TEP) Inguinal Hernia Repair With Ultrapro Lightweight Mesh: 5-Year Results of a Randomized Controlled Trial (TULP-trial) Annals of surgery 2018;268 (2):241-246 [PubMed]

2016

  • de Bruin Alain, Cornelissen Peter W. A., Kirchmaier Bettina C., Mokry Michal, Iich Elhadi, Nirmala Ella, Liang Kuo-Hsuan, D Végh Anna M., Scholman Koen T., Groot Koerkamp Marian J., Holstege Frank C., Cuppen Edwin, Schulte-Merker Stefan, Bakker Walbert J. Genome-wide analysis reveals NRP1 as a direct HIF1 alpha-E2F7 target in the regulation of motorneuron guidance in vivo Nucleic acids research 2016;44 (8):3549-3566 [PubMed]

2013

  • Bakker Walbert J., Weijts Bart G. M. W., Westendorp Bart, de Bruin Alain HIF proteins connect the RB-E2F factors to angiogenesis Transcription 2013;4 (2):62-66 [PubMed]

2012

  • Weijts Bart G. M. W., Bakker Walbert J., Cornelissen Peter W. A., Liang Kuo-Hsuan, Schaftenaar Frank H., Westendorp Bart, de Wolf Charlotte A. C. M. T., Paciejewska Maya, Scheele Colinda L. G. J., Kent Lindsey, Leone Gustavo, Schulte-Merker Stefan, de Bruin Alain E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1 EMBO journal 2012;31 (19):3871-3884 [PubMed]

2011

  • Zaugg Kathrin, Yao Yi, Reilly Patrick T., Kannan Karuppiah, Kiarash Reza, Mason Jacqueline, Huang Ping, Sawyer Suzanne K., Fuerth Benjamin, Faubert Brandon, Kalliomäki Tuula, Elia Andrew, Luo Xunyi, Nadeem Vincent, Bungard David, Yalavarthi Sireesha, Growney Joseph D., Wakeham Andrew, Moolani Yasmin, Silvester Jennifer, ten Annick You, Bakker Walbert, Tsuchihara Katsuya, Berger Shelley L., Hill Richard P., Jones Russell G., Tsao Ming, Robinson Murray O., Thompson Craig B., Pan Guohua, Mak Tak W. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Genes & development 2011;25 (10):1041-1051 [PubMed]

2008

  • Grech Godfrey, Blázquez-Domingo Montserrat, Kolbus Andrea, Bakker Walbert J., Müllner Ernst W., Beug Hartmut, von Lindern Marieke Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation Blood 2008;112 (7):2750-2760 [PubMed]

2007

  • Bakker Walbert J., van Dijk Thamar B., Parren-van Amelsvoort Martine, Kolbus Andrea, Yamamoto Kazuo, Steinlein Peter, Verhaak Roel G. W., Mak Tak W., Beug Hartmut, Löwenberg Bob, von Lindern Marieke Differential regulation of Foxo3a target genes in erythropoiesis Molecular and cellular biology 2007;27 (10):3839-3854 [PubMed]
  • Bakker Walbert J., Harris Isaac S., Mak Tak W. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2 Molecular cell 2007;28 (6):941-953 [PubMed]

2004

  • Bakker Walbert J., Blázquez-Domingo Montserrat, Kolbus Andrea, Besooyen Janey, Steinlein Peter, Beug Hartmut, Coffer Paul J., Löwenberg Bob, von Lindern Marieke, van Dijk Thamar B. FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1 Journal of cell biology 2004;164 (2):175-184 [PubMed]

2003

  • Kolbus Andrea, Blázquez-Domingo Montserrat, Carotta Sebastian, Bakker Walbert, Luedemann Susanna, von Lindern Marieke, Steinlein Peter, Beug Hartmut Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling Blood 2003;102 (9):3136-3146 [PubMed]