Prof. A.J. Verhoeven PhD publications

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wiwir_publications_by Prof. A.J. Verhoeven PhD

Positions
Full Professor, Research Associate
Main activities
Education, Research
Specialisation
Medical Biochemistry
Focus of research
My research comprises 3 lines of investigation:
1. to identify with system biology approaches critical factors affecting the development of insulin resistance (IR) and type 2 diabetes (T2D) in obese individuals. A vast amount of data has recently become available from genomic and metabolomic studies, but the challenge is to integrate these data into a comprehensive model of obesity-induced changes. Our approaches include causal network analysis, modelling of whole body glucose metabolism and controlled manipulation of the expression of candidate genes in human cell lines. Particular attention is given to the importance of changes in glycosphingolipid metabolism (in collaboration with Prof. J.M. Aerts, Dept of Med Biochemistry, AMC). 
2. to study the differentiation process of adipocytes in order to understand the derangements caused by metabolic overloading. This research is carried out in ex vivo model systems and in samples obtained from human studies (in collaboration with the Metabolic Unit at the AMC, Dr. M.J. Serlie).
My research is supported by the AMC Innovation Impulse.

2019

  • Bontekoe Ide J. Optimization of blood component preparation: Processing and donor influence 2019. 201p. ISBN 9789463753661. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Verhoeven A. J. , van der Meer P. F.; Co-supervisor: de Korte D.)
  • Bontekoe Ido J., van der Meer Pieter F., Verhoeven Arthur J., de Korte Dirk Platelet storage properties are associated with donor age: in vitro quality of platelets from young donors and older donors with and without Type 2 diabetes Vox sanguinis 2019;114 (2):129-136 [PubMed]

2018

  • Tol Marc J., van der Lienden Martijn J. C., Gabriel Tanit L., Hagen Jacob J., Scheij Saskia, Veenendaal Tineke, Klumperman Judith, Donker-Koopman Wilma E., Verhoeven Arthur J., Overkleeft Hermen, Aerts Johannes M., Argmann Carmen A., van Eijk Marco HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution Autophagy 2018;14 (3):437-449 [PubMed]
  • Gilglioni Eduardo H., Chang Jung Chin, Duijst Suzanne, Go Simei, Adam Aziza A. A. , Hoekstra Ruurdtje, Verhoeven Arthur J., Ishii-Iwamoto Emy L., Oude Elferink Ronald P. J. Improved oxygenation dramatically alters metabolism and gene expression in cultured primary mouse hepatocytes Hepatology Communications 2018;2 (3):299-312 [PubMed]
  • Held Ntsiki M., Kuipers Eline N., van Weeghel Michel, van Klinken Jan Bert, Denis Simone W., Lombès Marc, Wanders Ronald J., Vaz Frédéric M., Rensen Patrick C. N., Verhoeven Arthur J., Boon Mariëtte R., Houtkooper Riekelt H. Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation Scientific reports 2018;8 (1) [PubMed]
  • Chang Jung-Chin, Go Simei, Verhoeven Arthur J., Beuers Ulrich, Oude Elferink Ronald P. J. Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018;1864 (4B):1232-1239 [PubMed]
  • Chang Jung-Chin Soluble adenylyl cyclase: A regulator of intrinsic cellular functions 2018. 259p. ISBN 9789402812961. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Oude Elferink R. P. J., Verhoeven A. J.; Co-supervisor: Paulusma C. C.)

2017

  • Lelkens Charles C. M. Frozen red cells for military and civil purposes relevance, experiences and developments 2017. 171p. ISBN 9789082695908. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Verhoeven A. J.; Co-supervisors: Lagerberg J. W. M., de Korte D.)
  • Gao Yuanqing, Vidal-Itriago Andrés, Kalsbeek Martin J., Layritz Clarita, García-Cáceres Cristina, Tom Robby Zachariah, Eichmann Thomas O., Vaz Frédéric M., Houtkooper Riekelt H., van der Wel Nicole, Verhoeven Arthur J., Yan Jie, Kalsbeek Andries, Eckel Robert H., Hofmann Susanna M., Yi Chun-Xia Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity Cell reports 2017;20 (13):3034-3042 [PubMed]
  • Bontekoe Ido J., van der Meer Pieter F., van den Hurk Katja, Verhoeven Arthur J., de Korte Dirk Platelet storage performance is consistent by donor: a pilot study comparing "good" and "poor" storing platelets Transfusion 2017;57 (10):2373-2380 [PubMed]

2016

  • Tol Marc J., Ottenhoff Roelof, van Eijk Marco, Zelcer Noam, Aten Jan, Houten Sander M., Geerts Dirk, van Roomen Cindy, Bierlaagh Marlou C., Scheij Saskia, Hoeksema Marten A., Aerts Johannes M., Bogan Jonathan S., Dorn Gerald W., Argmann Carmen A., Verhoeven Arthur J. A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity Diabetes 2016;65 (9):2591-2605 [PubMed]
  • Tol Marc J. P. M. Deregulation of lysosomal and mitochondrial dynamics in obesity 2016. 169p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Verhoeven A. J.; Co-supervisors: Zelcer N., van Eijk M. C.)

2015

  • van Zwieten Robert Rare red blood cell abnormalities 2015. 277p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Verhoeven A. J.; Co-supervisors: Roos D., van Wijk R., van Bruggen R.)

2014

  • van Zwieten Rob, Verhoeven Arthur J., Roos Dirk Inborn defects in the antioxidant systems of human red blood cells Free radical biology & medicine 2014;67:377-386 [PubMed]
  • Almac Emre, Bezemer Rick, Hilarius-Stokman Petra M., Goedhart Peter, de Korte Dirk, Verhoeven Arthur J., Ince Can Red blood cell storage increases hypoxia-induced nitric oxide bioavailability and methemoglobin formation in vitro and in vivo Transfusion 2014;54 (12):3178-3185 [PubMed]

2013

  • de Cuyper Iris M., Meinders Marjolein, van de Vijver Edith, de Korte Dirk, Porcelijn Leendert, de Haas Masja, Eble Johannes A., Seeger Karl, Rutella Sergio, Pagliara Daria, Kuijpers Taco W., Verhoeven Arthur J., van den Berg Timo K., Gutiérrez Laura A novel flow cytometry-based platelet aggregation assay Blood 2013;121 (10):E70-E80 [PubMed]
  • Brands Myrte, Swat Maciej, Lammers Nicolette M., Sauerwein Hans P., Endert Erik, Ackermans Mariëtte T., Verhoeven Arthur J., Serlie Mireille J. Effects of a hypercaloric diet on β-cell responsivity in lean healthy men Clinical endocrinology 2013;78 (2):217-225 [PubMed]
  • Lorin Séverine, Tol Marc J., Bauvy Chantal, Strijland Anneke, Poüs Christian, Verhoeven Arthur J., Codogno Patrice, Meijer Alfred J. Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy Autophagy 2013;9 (6):850-860 [PubMed]
  • van Zwieten Rob, François Jerney J. J. M., van Leeuwen Karin, van Wesel Annet C. W., van Bruggen Robin, van Solinge Wouter W., Roos Dirk, Verhoeven Arthur J., van Wijk Richard Hereditary spherocytosis due to band 3 deficiency: 15 novel mutations in SLC4A1 American journal of hematology 2013;88 (2):159-160 [PubMed]
  • Brands M., van Raalte D. H., João Ferraz M., Sauerwein H. P., Verhoeven A. J., Aerts J. M. F. G., Diamant M., Serlie M. J. No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men Journal of clinical endocrinology and metabolism 2013;98 (3):1219-1225 [PubMed]
  • Brands Myrte Pathophysiological mechanisms of insuline resistance 2013. 263p. ISBN 9789461918963. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Sauerwein H. P., Verhoeven A. J.; Co-supervisor: Serlie M. J.)
  • Burger Patrick, Kostova Elena, Bloem Esther, Hilarius-Stokman Petra, Meijer Alexander B., van den Berg Timo K., Verhoeven Arthur J., de Korte Dirk, van Bruggen Robin Potassium leakage primes stored erythrocytes for phosphatidylserine exposure and shedding of pro-coagulant vesicles British journal of haematology 2013;160 (3):377-386 [PubMed]

2012

  • Burger Patrick, Korsten Herbert, Verhoeven Arthur J., de Korte Dirk, van Bruggen Robin Collection and storage of red blood cells with anticoagulant and additive solution with a physiologic pH Transfusion 2012;52 (6):1245-1252 [PubMed]
  • Lombardo Elisa, van Roomen Cindy P. A. A., van Puijvelde Gijs H., Ottenhoff Roelof, van Eijk Marco, Aten Jan, Kuiper Johan, Overkleeft Herman S., Groen Albert K., Verhoeven Arthur J., Aerts Johannes M. F. G., Bietrix Florence Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism PLoS ONE 2012;7 (10):e38520-(10 p.) [PubMed]
  • van de Vijver Edith, de Cuyper Iris M., Gerrits Anja J., Verhoeven Arthur J., Seeger Karl, Gutiérrez Laura, van den Berg Timo K., Kuijpers Taco W. Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin beta 1 and beta 3 in platelet adhesion to collagen Blood 2012;119 (2):583-586 [PubMed]
  • Burger Patrick Red cell storage, lesion and clearance 2012. 129p. ISBN 9789461821478. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Verhoeven A. J.; Co-supervisors: de Korte D., van Bruggen R.)
  • Brands Myrte, Verhoeven Arthur J., Serlie Mireille J. Role of mitochondrial function in insulin resistance Advances in experimental medicine and biology 2012;942:215-234 [PubMed]
  • van Zwieten Rob, Bochem Andrea E., Hilarius Petra M., van Bruggen Robin, Bergkamp Ferry, Hovingh G. Kees, Verhoeven Arthur J. The cholesterol content of the erythrocyte membrane is an important determinant of phosphatidylserine exposure BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2012;1821 (12):1493-1500 [PubMed]

2011

  • Hakvoort Theodorus B. M., Moerland Perry D., Frijters Raoul, Sokolovic Aleksandar, Labruyere Wilhelmina T., Vermeulen Jacqueline L. M., Ver Loren van Themaat Emiel, Breit Timo M., Wittink Floyd R. A., van Kampen Antoine H. C., Verhoeven Arthur J., Lamers Wouter H., Sokolovic Milka Interorgan Coordination of the Murine Adaptive Response to Fasting Journal of biological chemistry 2011;286 (18):16332-16343 [PubMed]
  • Swat Maciej, Kiełbasa Szymon M., Polak Sebastian, Olivier Brett, Bruggeman Frank J., Tulloch Mark Quinton, Snoep Jacky L., Verhoeven Arthur J., Westerhoff Hans V. What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform Interface focus 2011;1 (1):16-23 [PubMed]

2010

  • Burger Patrick, Korsten Herbert, de Korte Dirk, Rombout Eva, van Bruggen Robin, Verhoeven Arthur J. An improved red blood cell additive solution maintains 2,3-diphosphoglycerate and adenosine triphosphate levels by an enhancing effect on phosphofructokinase activity during cold storage Transfusion 2010;50 (11):2386-2392 [PubMed]
  • van Eijk Marco, Voorn-Brouwer Tineke, Scheij Saskia S., Verhoeven Arthur J., Boot Rolf G., Aerts Johannes M. F. G. Curdlan-mediated regulation of human phagocyte-specific chitotriosidase FEBS letters 2010;584 (14):3165-3169 [PubMed]
  • Bietrix Florence, Lombardo Elisa, van Roomen Cindy P. A. A., Ottenhoff Roelof, Vos Mariska, Rensen Patrick C. N., Verhoeven Arthur J., Aerts Johannes M., Groen Albert K. Inhibition of Glycosphingolipid Synthesis Induces a Profound Reduction of Plasma Cholesterol and Inhibits Atherosclerosis Development in APOE*3 Leiden and Low-Density Lipoprotein Receptor-/- Mice Arteriosclerosis, thrombosis, and vascular biology 2010;30 (5):931-937 [PubMed]
  • Krijnen Paul A. J., Sipkens Jessica A., Molling Johan W., Rauwerda Jan A., Stehouwer Coen D. A., Muller Alice, Paulus Walter J., van Nieuw Amerongen Geerten P., Hack C. Erik, Verhoeven Arthur J., van Hinsbergh Victor W. M., Niessen Hans W. M. Inhibition of Rho - ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase Journal of molecular and cellular cardiology 2010;49 (5):781-790 [PubMed]

2009

  • van Bruggen Robin, Drewniak Agata, Jansen Machiel, van Houdt Michel, Roos Dirk, Chapel Helen, Verhoeven Arthur J., Kuijpers Taco W. Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles Molecular immunology 2009;47 (2-3):575-581 [PubMed]
  • Kuijpers Taco W., van de Vijver Edith, Weterman Marian A. J., de Boer Martin, Tool Anton T. J., van den Berg Timo K., Moser Markus, Jakobs Marja E., Seeger Karl, Sanal Ozden, Unal Sule, Cetin Mualla, Roos Dirk, Verhoeven Arthur J., Baas Frank LAD-1/variant syndrome is caused by mutations in FERMT3 Blood 2009;113 (19):4740-4746 [PubMed]
  • van Raam Bram J. Mitochondria in neutrophil apoptosis 2009. 141p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kuijpers T. W., Roos D.; Co-supervisor: Verhoeven A. J.)
  • Raat Nicolaas J. H., Hilarius Petra M., Johannes Tanja, de Korte Dirk, Ince Can, Verhoeven Arthur J. Rejuvenation of stored human red blood cells reverses the renal microvascular oxygenation deficit in an isovolemic transfusion model in rats Transfusion 2009;49 (3):427-434 [PubMed]

2008

  • Paulusma Coen C., Folmer Dineke E., Ho-Mok Kam S., de Waart D. Rudi, Hilarius Petra M., Verhoeven Arthur J., Oude Elferink Ronald P. J. ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity Hepatology (Baltimore, Md.) 2008;47 (1):268-278 [PubMed]
  • van Raam Bram J., Sluiter Wim, de Wit Elly, Roos Dirk, Verhoeven Arthur J., Kuijpers Taco W. Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation PLoS ONE 2008;3 (4):e2013 [PubMed]
  • Terpstra Fokke G., van 't Wout Angélique B., Schuitemaker Hanneke, van Engelenburg Frank A. C., Dekkers David W. C., Verhaar Robin, de Korte Dirk, Verhoeven Arthur J. Potential and limitation of UVC irradiation for the inactivation of pathogens in platelet concentrates Transfusion 2008;48 (2):304-313 [PubMed]
  • de Korte Dirk, Kleine Mya, Korsten Herbert G. H., Verhoeven Arthur J. Prolonged maintenance of 2,3-diphosphoglycerate acid and adenosine triphosphate in red blood cells during storage Transfusion 2008;48 (6):1081-1089 [PubMed]
  • Verhaar Robin, Dekkers David W. C., de Cuyper Iris M., Ginsberg Mark H., de Korte Dirk, Verhoeven Arthur J. UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3 Blood 2008;112 (13):4935-4939 [PubMed]

2007

  • Lagerberg Johan W. M., Truijens-de Lange Rosa, de Korte Dirk, Verhoeven Arthur J. Altered processing of thawed red cells to improve the in vitro quality during postthaw storage at 4 degrees C Transfusion 2007;47 (12):2242-2249 [PubMed]
  • van Bruggen Robin, Zweers Debby, van Diepen Angela, van Dissel Jaap T., Roos Dirk, Verhoeven Arthur J., Kuijpers Taco W. Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils Infection and immunity 2007;75 (6):2655-2660 [PubMed]
  • Dekkers David W. C., de Cuyper Iris M., van der Meer Pieter F., Verhoeven Arthur J., de Korte Dirk Influence of pH on stored human platelets Transfusion 2007;47 (10):1889-1895 [PubMed]
  • Kuijpers Taco W., van Bruggen Robin, Kamerbeek Nanne, Tool Anton T. J., Hicsonmez Gonul, Gurgey Aytemiz, Karow Axel, Verhoeven Arthur J., Seeger Karl, Sanal Ozden, Niemeyer Charlotte, Roos Dirk Natural history and early diagnosis of LAD-1/variant syndrome Blood 2007;109 (8):3529-3537 [PubMed]
  • Matmati Mourad, Pouwels Walter, van Bruggen Robin, Jansen Machiel, Hoek Robert M., Verhoeven Arthur J., Hamann Jörg The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes Journal of leukocyte biology 2007;81 (2):440-448 [PubMed]

2006

  • Trannoy L. L., Terpstra F. G., de Korte D., Lagerberg J. W. M., Verhoeven A. J., Brand A., van Engelenburg F. A. C. Differential sensitivities of pathogens in red cell concentrates to Tri-P(4)-photoinactivation Vox sanguinis 2006;91 (2):111-118 [PubMed]
  • van Raam B. J., Verhoeven A. J., Kuijpers T. W. Mitochondria in neutrophil apoptosis International journal of hematology 2006;84 (3):199-204 [PubMed]
  • Verhoeven A. J., Hilarius P. M., Dekkers D. W. C., Lagerberg J. W. M., de Korte D. Prolonged storage of red blood cells affects aminophospholipid translocase activity Vox sanguinis 2006;91 (3):244-251 [PubMed]

2005

  • van Eijk Marco, van Roomen Cindy P. A. A., Renkema G. Herma, Bussink Anton P., Andrews Laura, Blommaart Edward F. C., Sugar Alan, Verhoeven Arthur J., Boot Rolf G., Aerts Johannes M. F. G. Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity International immunology 2005;17 (11):1505-1512 [PubMed]
  • Raat N. J. H., Berends F., Verhoeven A. J., de Korte D., Ince C. The age of stored red blood cell concentrates at the time of transfusion Transfusion medicine (Oxford, England) 2005;15 (5):419-423 [PubMed]
  • Raat N. J., Verhoeven A. J., Mik E. G., Gouwerok C. W., Verhaar R., Goedhart P. T., de Korte D., Ince C. The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model Critical care medicine 2005;33 (1):39-45 [PubMed]
  • Verhoeven Arthur J., Verhaar Robin, Gouwerok Eric G. W., de Korte Dirk The mitochondrial membrane potential in human platelets: a sensitive parameter for platelet quality Transfusion 2005;45 (1):82-89 [PubMed]

2004

  • Hilarius P. M., Ebbing I. G., Dekkers D. W. C., Lagerberg J. W. M., de Korte D., Verhoeven A. J. Generation of singlet oxygen induces phospholipid scrambling in human erythrocytes Biochemistry 2004;43 (13):4012-4019 [PubMed]
  • Kuijpers Taco W., Maianski Nikolai A., Tool Anton T. J., Becker Kolja, Plecko Barbara, Valianpour Fredoen, Wanders Ron J. A., Pereira Rob, van Hove Johan, Verhoeven Arthur J., Roos Dirk, Baas Frank, Barth Peter G. Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis Blood 2004;103 (10):3915-3923 [PubMed]
  • de Korte D., Verhoeven A. J. Quality determinants of erythrocyte destined for transfusion Cellular and molecular biology (Noisy-le-Grand, France) 2004;50 (2):187-195 [PubMed]

2003

  • Besselink G. A. J., van Engelenburg F. A. C., Ebbing I. G., Hilarius P. M., de Korte D., Verhoeven A. J. Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment Vox sanguinis 2003;85 (1):25-30 [PubMed]
  • Dijkstra-Tiekstra M. J., de Korte D., Pietersz R. N. I., Reesink H. W., van der Meer P. F., Verhoeven A. J. Comparison of various dimethylsulphoxide-containing solutions for cryopreservation of leucoreduced platelet concentrates Vox sanguinis 2003;85 (4):276-282 [PubMed]
  • Besselink G. A. J., Ebbing I. G., Hilarius P. M., de Korte D., Verhoeven A. J., Lagerberg J. W. M. Composition of the additive solution affects red blood cell integrity after photodynamic treatment Vox sanguinis 2003;85 (3):183-189 [PubMed]
  • Hardeman Max R., Besselink Geert A. J., Ebbing Iwan, de Korte Dirk, Ince Can, Verhoeven Arthur J. Laser-assisted optical rotational cell analyzer measurements reveal early changes in human RBC deformability induced by photodynamic treatment Transfusion 2003;43 (11):1533-1537 [PubMed]
  • Lelkens Charles C. M., Noorman Femke, Koning Jack G., Truijens-de Lange Rosa, Stekkinger Perry S., Bakker Joa C., Lagerberg Johan W. M., Brand Anneke, Verhoeven Arthur J. Stability after thawing of RBCs frozen with the high- and low-glycerol method Transfusion 2003;43 (2):157-164 [PubMed]

2002

  • de Korte D., Marcelis J. H., Verhoeven A. J., Soeterboek A. M. Diversion of first blood volume results in a reduction of bacterial contamination for whole-blood collections Vox sanguinis 2002;83 (1):13-16 [PubMed]
  • Besselink G. A. J., van Engelenburg F. A. C., Korsten H. G., Blokker D. E., Lagerberg J. W. A., Brand A., de Korte D., Verhoeven A. J. The band III ligand dipyridamole protects human RBCs during photodynamic treatment while extracellular virus inactivation is not affected Transfusion 2002;42 (6):728-733 [PubMed]

2001

  • Kostelijk E. H., Klomp A. J., Engbers G. H., Gouwerok C. W., Verhoeven A. J., van Aken W. G., Feijen J., de Korte D. Improved platelet compatiblity of water vapour glow discharge treated non-woven poly(ethylene terephthalate) leukocyte-reduction filters for different types of platelet concentrates Transfusion medicine (Oxford, England) 2001;11 (3):199-205 [PubMed]
  • Zuurbier A. E., Liu L., Mul F. P., Verhoeven A. J., Knol E. F., Roos D. Neutrophils enhance eosinophil migration across monolayers of lung epithelial cells Clinical and experimental allergy 2001;31 (3):444-452 [PubMed]
  • van Bommel J., de Korte D., Lind A., Siegemund M., Trouwborst A., Verhoeven A. J., Ince C., Henny C. P. The effect of the transfusion of stored RBCs on intestinal microvascular oxygenation in the rat Transfusion 2001;41 (12):1515-1523 [PubMed]

2000

  • Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly Blood 2000;95 (2):666-673 [PubMed]
  • Increase in glycocalicin levels in platelet concentrates stored in plasma or synthetic medium for 8 days: comparison with other platelet activation markers Vox sanguinis 2000;79 (1):21-26 [PubMed]
  • Intracellular reactions in single human granulocytes upon phorbol myristate acetate activation using confocal Raman microspectroscopy Biophysical journal 2000;78 (5):2606-2613 [PubMed]
  • Bleeker W. K., Teeling J. L., Verhoeven A. J., Rigter G. M., Agterberg J., Tool A. T., Koenderman A. H., Kuijpers T. W., Hack C. E. Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase Blood 2000;95 (5):1856-1861 [PubMed]

1999

  • Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils Biochemical journal 1999;340 ( Pt 1):95-101 [PubMed]

1998

  • Adult respiratory distress syndrome after experimental intravenous gamma-globulin concentrate and monocyte-reactive IgG antibodies Lancet 1998;352 (9140):1601-1602 [PubMed]
  • Degranulation of human basophils by picomolar concentrations of IL-3, IL-5, or granulocyte-macrophage colony-stimulating factor Journal of allergy and clinical immunology 1998;101 (5):683-690 [PubMed]
  • Human eosinophils express, relative to other circulating leukocytes, large amounts of secretory 14-kD phospholipase A2 Blood 1998;91 (8):3037-3043 [PubMed]
  • Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator Journal of immunology (Baltimore, Md. 1998;161 (6):3064-3070 [PubMed]

1997

  • Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients Arteriosclerosis, thrombosis, and vascular biology 1997;17 (11):2837-2842 [PubMed]
  • Kuijpers T. W., van Lier R. A., Hamann D., de Boer M., Thung L. Y., Weening R. S., Verhoeven A. J., Roos D. Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins Journal of clinical investigation 1997;100 (7):1725-1733 [PubMed]

1996

  • Alteration of B-cell antigen receptor signaling by CD19 co-ligation. A study with bispecific antibodies Journal of biological chemistry 1996;271 (37):22326-22330 [PubMed]
  • Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease Journal of experimental medicine 1996;184 (4):1243-1249 [PubMed]
  • Interactions between the components of the human NADPH oxidase: intrigues in the phox family Journal of laboratory and clinical medicine 1996;128 (5):461-476 [PubMed]
  • Limitations on the use of dihydrorhodamine 123 for flow cytometric analysis of the neutrophil respiratory burst Journal of immunological methods 1996;191 (2):187-196 [PubMed]

1995

  • Heterotypic Fc gamma R clusters evoke a synergistic Ca2+ response in human neutrophils Journal of biological chemistry 1995;270 (18):10671-10679 [PubMed]
  • Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro Blood 1995;85 (2):532-540 [PubMed]
  • Interactions between the cytosolic components p47phox and p67phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system Journal of biological chemistry 1995;270 (19):11216-11221 [PubMed]

1994

  • Leusen J. H., Bolscher B. G., Hilarius P. M., Weening R. S., Kaulfersch W., Seger R. A., Roos D., Verhoeven A. J. 156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox Journal of experimental medicine 1994;180 (6):2329-2334 [PubMed]
  • Leusen J. H., de Boer M., Bolscher B. G., Hilarius P. M., Weening R. S., Ochs H. D., Roos D., Verhoeven A. J. A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox Journal of clinical investigation 1994;93 (5):2120-2126 [PubMed]
  • Lankester A. C., van Schijndel G. M., Rood P. M., Verhoeven A. J., van Lier R. A. B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation European journal of immunology 1994;24 (11):2818-2825 [PubMed]

1993

  • A novel syndrome of severe neutrophil dysfunction: unresponsiveness confined to chemotaxin-induced functions Blood 1993;81 (10):2735-2743 [PubMed]
  • Calafat J., Kuijpers T. W., Janssen H., Borregaard N., Verhoeven A. J., Roos D. Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18 Blood 1993;81 (11):3122-3129 [PubMed]
  • Nimesulide inhibits platelet-activating factor synthesis in activated human neutrophils Drugs 1993;46 (Suppl. 1):52-58 [PubMed]
  • Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils Journal of clinical investigation 1993;91 (3):1035-1043 [PubMed]

1992

  • Intracellular events in anti-IgE nonreleasing human basophils Journal of allergy and clinical immunology 1992;90 (1):92-103 [PubMed]

1991

  • van Kooyk Y., Weder P., Hogervorst F., Verhoeven A. J., van Seventer G., te Velde A. A., Borst J., Keizer G. D., Figdor C. G. Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion Journal of cell biology 1991;112 (2):345-354 [PubMed]
  • Koenderman L., Kuijpers T. W., Blom M., Tool A. T., Roos D., Verhoeven A. J. Characteristics of CR3-mediated aggregation in human eosinophils: effect of priming by platelet-activating factor Journal of allergy and clinical immunology 1991;87 (5):947-954 [PubMed]
  • Kuijpers T. W., Tool A. T., van der Schoot C. E., Ginsel L. A., Onderwater J. J., Roos D., Verhoeven A. J. Membrane surface antigen expression on neutrophils: a reappraisal of the use of surface markers for neutrophil activation Blood 1991;78 (4):1105-1111 [PubMed]
  • Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription European journal of immunology 1991;21 (1):167-172 [PubMed]
  • Release of azurophilic granule contents in fMLP-stimulated neutrophils requires two activation signals, one of which is a rise in cytosolic free Ca2+ Cellular signalling 1991;3 (6):625-633 [PubMed]
  • van Lier R. A., Brouwer M., de Groot E. D., Kramer I., Aarden L. A., Verhoeven A. J. T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways European journal of immunology 1991;21 (7):1775-1778 [PubMed]

1990

  • Kuypers T. W., Koenderman L., Weening R. S., Verhoeven A. J., Roos D. Continuous cell activation is necessary for stable interaction of complement receptor type 3 with its counter-structure in the aggregation response of human neutrophils European journal of immunology 1990;20 (3):501-508 [PubMed]

1989

  • A phosphoprotein of Mr 47,000, defective in autosomal chronic granulomatous disease, copurifies with one of two soluble components required for NADPH:O2 oxidoreductase activity in human neutrophils Journal of clinical investigation 1989;83 (3):757-763 [PubMed]
  • Verhoeven A. J., Bolscher B. G., Meerhof L. J., van Zwieten R., Keijer J., Weening R. S., Roos D. Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils Blood 1989;73 (6):1686-1694 [PubMed]

1988

  • Detection of carriers of the autosomal form of chronic granulomatous disease Blood 1988;71 (2):505-507 [PubMed]
  • Kramer I. M., Verhoeven A. J., van der Bend R. L., Weening R. S., Roos D. Purified protein kinase C phosphorylates a 47-kDa protein in control neutrophil cytoplasts but not in neutrophil cytoplasts from patients with the autosomal form of chronic granulomatous disease Journal of biological chemistry 1988;263 (5):2352-2357 [PubMed]

1987

  • Functional studies with anti-CD3 heavy chain isotype switch-variant monoclonal antibodies. Accessory cell-independent induction of interleukin 2 responsiveness in T cells by epsilon-anti-CD3 Journal of immunology (Baltimore, Md. 1987;139 (9):2873-2879 [PubMed]

1986

  • Regulation of mitochondrial respiration in liver Advances in experimental medicine and biology 1986;194:241-254 [PubMed]
  • Leverve X. M., Verhoeven A. J., Groen A. K., Meijer A. J., Tager J. M. THE MALATE ASPARTATE SHUTTLE AND PYRUVATE-KINASE AS TARGETS INVOLVED IN THE STIMULATION OF GLUCONEOGENESIS BY PHENYLEPHRINE European Journal of Biochemistry / FEBS 1986;155 (3):551-556 [PubMed]

1985

  • APPLICATION OF CONTROL ANALYSIS IN STUDIES OF REGULATION OF INTERMEDIARY METABOLISM Biomedica biochimica acta 1985;44 (6):943-952 [PubMed]
  • EFFECTS OF THYROID-HORMONE ON MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION Biochemical journal 1985;226 (1):183-192 [PubMed]
  • KINETIC-ANALYSIS OF SHORT-TERM EFFECTS OF ALPHA-AGONISTS ON GLUCONEOGENESIS IN ISOLATED RAT HEPATOCYTES FEBS letters 1985;181 (1):43-46 [PubMed]

Corona-maatregelen

We zetten ons in om ons ziekenhuis veilig te houden tijdens de coronacrisis.

Lees deze extra maatregelen goed door voordat u een van onze locaties bezoekt: