Prof. H.P. Beerlage PhD publications


Publications Prof. H.P. Beerlage PhD

Full Professor
Main activities
Research, Other
Focus of research

Prostate cancer is the most common malignancy in men and 2500 men die from prostate cancer every year in The Netherlands. In order to diagnose prostate cancer the PSA bloodtest is widely used but suffers from low sensitivity and specificity. This leads to unneccesary invasive testing (prostate biopsy) on the one hand with associated complications in many patients while in over 60% of cases no significant tumor is found on biopsies. On the other hand this test may be omitted unjustified in patients who have a significant malignancy. The key solution to this problem is better imaging. Prostate cancer is poorly visible on imaging although significant progress has been made in recent years using MR scanning. However MR is expensive and over 10% of prostate tumors will be missed. Ideally it would be possible to make a correct diagnosis with imaging only, selecting those who do need a biopsy, or even better being able to justly omit biopsy at all. Together with our collegues at the Technical University Eindhoven we investigate multiparametric ultrasound scanning in the diagnosis of prostate cancer. To date our research shows contrast enhanced ultasound scanning of the prostate is approaching the results of MR scanning. But the field of ultrasound scanning is evolving tremendously resulting in the development of many new parameters. These all have to be tested in clinical setting which we do in AmsterdamUMC and in our clinical partner hospital.


  • Gayet Maudy C. W., Aa Anouk A. M. A. Van Der, Beerlage Harrie P., Schrier Bart Ph, Gielens Maaike, Heesakkers Roel, Jager Gerrit J., Mulders Peter F. A., Wijkstra Hessel Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI Prostate Cancer 2020;2020 [PubMed]
  • Postema Arnoud W., Gayet Maudy C. W., van Sloun Ruud J. G., Wildeboer Rogier R., Mannaerts Christophe K., Savci-Heijink C. Dilara, Schalk Stefan G., Kajtazovic Amir, van der Poel Henk, Mulders Peter F. A., Beerlage Harrie P., Mischi Massimo, Wijkstra Hessel Contrast-enhanced ultrasound with dispersion analysis for the localization of prostate cancer: correlation with radical prostatectomy specimens World journal of urology 2020 [PubMed]
  • de Vries A. H. (Heleen), Zondervan Patricia J., Beerlage Harrie P. Controverses, complicaties en nieuwe technieken in nierchirurgie Tijdschrift voor urologie 2020;10:15-17
  • Yildirim Hilin, Tanis Pieter J., de Reijke Theo M., Beerlage Harrie P., Hompes Roel, Oddens Jorg R. Een onbekende procedure: double-barreled wet colostomy Tijdschrift voor urologie 2020
  • Zondervan Patricia J. New developments in diagnosis and treatment of Small Renal Masses 2020. 211p. ISBN 9789463809627. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Beerlage Harrie P., van Delden Otto M.; Co-supervisors: Bex A., van Moorselaar R. J. A.)
  • Weenink R. P., Kloosterman M., Hompes R., Zondervan P. J., Beerlage H. P., Tanis P. J., van Hulst R. A. The AirSeal® insufflation device can entrain room air during routine operation Techniques in coloproctology 2020;24 (10):1077-1082 [PubMed]
  • van Kollenburg Rob A. A., van Riel Luigi A. M. J. G., Bloemen Paul R., Oddens Jorg R., de Reijke Theo M., Beerlage Harrie P., de Bruin Daniel Martijn Transperineal laser ablation treatment for lower urinary tract symptoms due to benign prostatic obstruction: Protocol for a prospective in vivo pilot study JMIR research protocols 2020;9 (1) [PubMed]


  • van Sloun Ruud J. G., Wildeboer Rogier R., Mannaerts Christophe K., Postema Arnoud W., Gayet Maudy, Beerlage Harrie P., Salomon Georg, Wijkstra Hessel, Mischi Massimo Deep Learning for Real-time, Automatic, and Scanner-adapted Prostate (Zone) Segmentation of Transrectal Ultrasound, for Example, Magnetic Resonance Imaging–transrectal Ultrasound Fusion Prostate Biopsy European urology focus 2019 [PubMed]
  • Henderickx Michaël M. E. L., Baard Joyce, Beerlage Harrie P., Kamphuis Guido M. Fluoroscopy-use during ureterorenoscopy: are urologists concerned about radiation exposure? A nationwide survey in Belgium and The Netherlands Acta chirurgica Belgica 2019 [PubMed]
  • Alberts Arnout R., Roobol Monique J., Verbeek Jan F. M., Schoots Ivo G., Chiu Peter K., Osses Daniël F., Tijsterman Jasper D., Beerlage Harrie P., Mannaerts Christophe K., Schimmöller Lars, Albers Peter, Arsov Christian Prediction of High-grade Prostate Cancer Following Multiparametric Magnetic Resonance Imaging: Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculators European urology 2019;75 (2):310-318 [PubMed]
  • Mannaerts Christophe K., Kajtazovic Amir, Lodeizen Olivia A. P., Gayet Maudy, Engelbrecht Marc R. W., Jager Gerrit J., Wijkstra Hessel, de Reijke Theo M., Beerlage Harrie P. The added value of systematic biopsy in men with suspicion of prostate cancer undergoing multiparametric MRI-targeted biopsy Urologic oncology 2019;37 (5):298.e1-298.e9 [PubMed]
  • Geerkens Maud J. M., Pouwels Nieck S. A., Beerlage Harry P. The effectiveness of lifestyle interventions to reduce side effects of androgen deprivation therapy for men with prostate cancer: a systematic review Quality of life research 2019:1-23 [PubMed]
  • van der Aa Anouk Anna Maria Arnoldus, Mannaerts Christophe Koenraad, Gayet Maudy C. W., van der Linden Johannes Cornelis, Schrier Barthold Philip, Sedelaar J. P. Michiel, Mischi Massimo, Beerlage Harrie P., Wijkstra Hessel Three-dimensional greyscale transrectal ultrasound-guidance and biopsy core preembedding for detection of prostate cancer: Dutch clinical cohort study BMC urology 2019;19 (1) [PubMed]


  • Wildeboer Rogier R., van Sloun Ruud J. G., Postema Arnoud W., Mannaerts Christophe K., Gayet Maudy, Beerlage Harrie P., Wijkstra Hessel, Mischi Massimo Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology Journal of Ultrasound 2018;21 (3):197-207 [PubMed]
  • van der Aa Anouk A. M. A., Mannaerts Christophe K., van der Linden Hans, Gayet Maudy, Schrier Bart Ph, Mischi Massimo, Beerlage Harrie P., Wijkstra Hessel Concordance of Gleason grading with three-dimensional ultrasound systematic biopsy and biopsy core pre-embedding World journal of urology 2018;36 (6):863-869 [PubMed]
  • Westgeest Hans M., Uyl-de Groot Carin, van Moorselaar Reindert J. A., de Wit Ronald, van den Bergh Alphonsus, Coenen Jules L. LM, Beerlage Harrie P., Hendriks Mathijs P., Bos Monique E. M., van den Berg Pieter, van de Wouw Agnès J., Spermon Roan, Boerma Michiel O., Geenen Maud M., Tick Lidwine W., Polee Marco B., Bloemendal Haiko J., Cordia Igor, Peters Frank P. J., de Vos Aad I., van de Bosch Joan, van den Eertwegh Alfons J. M., Gerritsen Winald R. Differences in trial and real-world populations in the dutch castration-resistant prostate cancer registry European urology focus 2018;4 (5):694-701 [PubMed]
  • Gayet Maudy, Mannaerts Christophe K., Nieboer D., Beerlage Harrie P., Wijkstra Hessel, Mulders Peter F. A., Roobol Monique J. Prediction of Prostate Cancer: External Validation of the ERSPC Risk Calculator in a Contemporary Dutch Clinical Cohort European urology focus 2018;4 (2):228-234 [PubMed]
  • Mannaerts Christophe K., Gayet Maudy, Verbeek Jan F. M., Engelbrecht Marc R. W., Savci Heijink Dilara D., Jager Gerrit J., Gielens M.P.M., van der Linden H., Beerlage Harrie P., de Reijke Theodorus M., Wijkstra Hessel, Roobol Monique J. Prostate cancer risk assessment in biopsy-naïve patients: The Rotterdam prostate cancer risk calculator in multiparametric magnetic resonance imaging-transrectal ultrasound (TRUS) fusion biopsy and systematic TRUS biopsy European Urology Oncology 2018;1 (2):109-117 [PubMed]


  • Gayet Maudy, van der Aa Anouk, Schmitz Peter, Beerlage Harrie P., Schrier Bart Ph, Mulders Peter F. A., Mischi Massimo, Wijkstra Hessel 3D Navigo™ versus TRUS-guided prostate biopsy in prostate cancer detection World journal of urology 2016;34 (9):1255-1260 [PubMed]
  • Gayet Maudy, van der Aa Anouk, Beerlage Harrie P., Schrier Bart Ph, Mulders Peter F. A., Wijkstra Hessel The value of magnetic resonance imaging and ultrasonography (MRI/US)-fusion biopsy platforms in prostate cancer detection: a systematic review BJU international 2016;117 (3):392-400 [PubMed]


  • Wieringa Fokko P., Bouma Henri, Eendebak Pieter T., van Basten Jean-Paul A., Beerlage Harrie P., Smits Geert A. H. J., Bos Jelte E. Improved depth perception with three-dimensional auxiliary display and computer generated three-dimensional panoramic overviews in robot-assisted laparoscopy Journal of medical imaging (Bellingham, Wash.) 2014;1 (1) [PubMed]


  • Blikkendaal Mathijs D., Twijnstra Andries R. H., Stiggelbout Anne M., Beerlage Harrie P., Bemelman Willem A., Jansen Frank Willem Achieving consensus on the definition of conversion to laparotomy: a Delphi study among general surgeons, gynecologists, and urologists Surgical endoscopy 2013;27 (12):4631-4639 [PubMed]
  • van der Poel Henk G., Beerlage Harry P., Klaver Sjoerd O. Commentaar: Robotchirurgie: Pas op de plaats? Nederlands tijdschrift voor geneeskunde 2013;157 (30)
  • van der Poel Henk G., Beerlage Harry P., Klaver Sjoerd O. Robotchirurgie: pas op de plaats? Nederlands tijdschrift voor geneeskunde 2013;157 (28) [PubMed]


  • Beganovic Aida, Beerlage Harrie P. Een jongen met stomp scrotaal letsel Nederlands tijdschrift voor geneeskunde 2012;156 (29) [PubMed]


  • van Poppel Pleun C. M., Stehouwer Coen D. A., Beutler Jaap J., Korst Mike B. J. M., Beerlage Harrie P., Hoogeveen Ellen K. Hyperchloremische metabole acidose bij een patient met een brickerlis Nederlands tijdschrift voor geneeskunde 2009;153 (21):1024-1028 [PubMed]
  • Meijer R. P., Gemen E. F. A., van Onna I. E. W., van der Linden J. C., Beerlage H. P., Kusters G. C. M. The value of an artificial neural network in the decision-making for prostate biopsies World journal of urology 2009;27 (5):593-598 [PubMed]
  • Persoon Marjolein C., Scherpbier Albert J. J. A., Oei S. Guid, Meijerink W. J. H. J., Schijven Marlies P., Schout Barbara, Beerlage Harrie P., Hendrikx Ad J. M. Zonder patiënt laparoscopisch leren opereren Nederlands tijdschrift voor geneeskunde 2009;153 (3):60-62 [PubMed]


  • Bochove-Overgaauw D. M., Beerlage H. P., Bosscha K., Gelderman W. A. H. Transanal endoscopic microsurgery for correction of rectourethral fistulae Journal of endourology / Endourological Society 2006;20 (12):1087-1090 [PubMed]


  • Roelink J. H., Beerlage H. P. Laparoscopische radicale prostatectomie (lapRRP) Nederlands tijdschrift voor urologie 2005;13 (1):3-10


  • van Basten J. P. A., Knipscheer B. C., Rademakers B. H. P., Beerlage H. P. De invloed van het kooldioxide pneumoperitoneum op hemodynamiek en nierfunctie Nederlands tijdschrift voor urologie 2004;12 (2):55-64


  • Beerlage Harrie P. Alternative therapies for localized prostate cancer. Current urology reports 2003;4 (3):216-220 [PubMed]
  • de Reijke T. M., Beerlage H. P., Hendrikx A. J. M., de la Rosette J. J. M. C. H., McKillop C. A. Prostate cancer: the right treatment for the right patient - Amsterdam, 17-18 January 2001 Prostate cancer and prostatic diseases 2003;6 (2):193-197 [PubMed]


  • Beerlage H. P., Joyce A. D. Conclusions European urology 2001;40 (1):92-94
  • Beerlage Harrie P., Aarnink R. G., Ruijter E. Th, Witjes J. A., Wijkstra H., van de Kaa C. A., Debruyne F. M. J., de la Rosette J. J. M. C. H. Correlation of transrectal ultrasound, computer analysis of transrectal ultrasound and histopathology of radical prostatectomy specimen Prostate cancer and prostatic diseases 2001;4 (1):56-62 [PubMed]


  • Beerlage Harrie P., Thüroff S., Madersbacher S., Zlotta A. R., Aus G., de Reijke T. M., de la Rosette J. J. Current status of minimally invasive treatment options for localized prostate carcinoma European urology 2000;37 (1):2-13 [PubMed]
  • Histopathological changes associated with high intensity focused ultrasound (HIFU) treatment for localised adenocarcinoma of the prostate Journal of clinical pathology 2000;53 (5):391-394 [PubMed]
  • Sedelaar J. P., Aarnink R. G., van Leenders G. J., Beerlage H. P., Debruyne F. M., Wijkstra H., de la Rosette J. J. The application of three-dimensional contrast-enhanced ultrasound to measure volume of affected tissue after HIFU treatment for localized prostate cancer European urology 2000;37 (5):559-568 [PubMed]
  • The place of radical prostatectomy in the treatment of early localized prostate cancer Radiotherapy and oncology 2000;57 (3):259-262 [PubMed]


  • Contrast angiosonography: a technology to improve Doppler ultrasound examinations of the prostate European urology 1999;35 (1):9-20 [PubMed]
  • Bogers H. A., Sedelaar J. P., Beerlage H. P., de la Rosette J. J., Debruyne F. M., Wijkstra H., Aarnink R. G. Contrast-enhanced three-dimensional power Doppler angiography of the human prostate: correlation with biopsy outcome Urology 1999;54 (1):97-104 [PubMed]
  • Beerlage Harrie P., van Leenders G. J., Oosterhof G. O., Witjes J. A., Ruijter E. T., van de Kaa C. A., Debruyne F. M., de la Rosette J. J. High-intensity focused ultrasound (HIFU) followed after one to two weeks by radical retropubic prostatectomy: results of a prospective study Prostate 1999;39 (1):41-46 [PubMed]
  • Transrectal high-intensity focused ultrasound using the Ablatherm device in the treatment of localized prostate carcinoma Urology 1999;54 (2):273-277 [PubMed]
  • Transrectal ultrasound imaging of the prostate: review and perspectives of recent developments Prostate cancer and prostatic diseases 1999;2 (5/6):241-252 [PubMed]


  • Considerations regarding prostate biopsies European urology 1998;34 (4):303-312 [PubMed]
  • Transrectal ultrasound of the prostate: innovations and future applications Journal of urology 1998;159 (5):1568-1579 [PubMed]
  • Bierkens A. F., Hendrikx A. J., de la Rosette J. J., Stultiens G. N., Beerlage H. P., Arends A. J., Debruyne F. M. Treatment of mid- and lower ureteric calculi: extracorporeal shock-wave lithotripsy vs laser ureteroscopy. A comparison of costs, morbidity and effectiveness British journal of urology 1998;81 (1):31-35 [PubMed]
  • Urolase v ultraline fibers in laser prostatectomy: 3-year follow-up of a randomized study Journal of endourology / Endourological Society 1998;12 (6):575-580 [PubMed]


  • Role of temporary stents in alternative treatment of benign prostatic hyperplasia Journal of endourology / Endourological Society 1997;11 (6):467-472 [PubMed]


  • Laser prostatectomy for patients with benign prostatic hyperplasia: a prospective randomized study comparing two different techniques using the Prolase-II fiber World journal of urology 1995;13 (2):123-125 [PubMed]


  • Association between haematoma after inguinal hernia repair and site of heparin injection European journal of surgery = Acta chirurgica 1992;158 (5):287-288 [PubMed]


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