Prof. S. Middeldorp MD PhD publications

2021

• Barco Stefano, Valerio Luca, Ageno Walter, Cohen Alexander T., Goldhaber Samuel Z., Hunt Beverley J., Iorio Alfonso, Jimenez David, Klok Frederikus A., Kucher Nils, Mahmoudpour Seyed Hamidreza, Middeldorp Saskia, Münzel Thomas, Tagalakis Vicky, Wendelboe Aaron M., Konstantinides Stavros V. Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000–18: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database lancet. Respiratory medicine 2021;9 (1):33-42 [PubMed]
• Hamulyak Eva N., Daams Joost G., Leebeek Frank W. G., Biemond Bart J., te Boekhorst Peter A. W., Middeldorp Saskia, Lauw Mandy N. A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms Blood advances 2021;5 (1):113-121
• le Gal Grégoire, Carrier Marc, Castellucci Lana A., Cuker Adam, Hansen John-Bjarne, Klok Frederikus A., Langlois Nicole J., Levy Jerrold H., Middeldorp Saskia, Righini Marc, Walters Sam, Klok Erik, Bauman Kreuziger Lisa, Schulman Sam, Skeith Leslie, Zakai Neil, Riva Nicoletta, Douxfils Jonathan, Kahn Susan, ten Cate-Hoek Arina, Konstantinides Stavros, Ghanima Waleed, Lang Irene, Galanaud Jean-Philippe, Moumneh Thomas, Gandara Esteban, Prandoni Paolo, Witmer Char, Lazo-Langner Alejandro, Robert-Ebadi Helia, Ní Áinle Fionnuala, Wu Cynthia, Wang Tzu-Fei, Zwicker Jeffrey, Lauw Mandy, Ay Cihan, Maus Gabriela Cesarman, Angchaisuksiri Pantep, Steiner Marie, Bartz Raquel, Connors Jean, Samama Marc, Spyropoulos Alex, Faraoni David, Iba Toshiaki, Kearon Clive, Canniegeter Suzanne, Morange Pierre, Brækkan Sigrid, Morelli Vania Development and implementation of common data elements for venous thromboembolism research: on behalf of SSC Subcommittee on official Communication from the SSC of the ISTH Journal of thrombosis and haemostasis 2021;19 (1):297-303 [PubMed]
• Hamulyák Eva N., Wiegers Hanke M. G., Scheres Luuk J. J., Hutten Barbara A., de Lange Maria E., Timmermans Anne, Westerweel Peter E., Nijziel Marten R., Kruip Marieke J. H. A., ten Wolde Marije, Ypma Paula F., Klok Frederikus A., Nieuwenhuizen Laurens, van Wissen Sanne, Hovens Marcel M. C., Faber Laura M., Kamphuisen Pieter W., Büller Harry R., Middeldorp Saskia Heavy menstrual bleeding on direct factor Xa inhibitors: Rationale and design of the MEDEA study Research and practice in thrombosis and haemostasis 2021;5 (1):223-230

2020

• Tritschler Tobias, Mathieu Marie-Eve, Skeith Leslie, Rodger Marc, Middeldorp Saskia, Brighton Timothy, Sandset Per Morten, Kahn Susan R., Angus Derek C., Blondon Marc, Bonten Marc J., Cattaneo Marco, Cushman Mary, Derde Lennie P. G., DeSancho Maria T., Diehl Jean-Luc, Goligher Ewan, Jilma Bernd, Jüni Peter, Lawler Patrick R., Marietta Marco, Marshall John C., McArthur Colin, Miranda Carlos Henrique, Mirault Tristan, Morici Nuccia, Perepu Usha, Schörgenhofer Christian, Sholzberg Michelle, Spyropoulos Alex C., Webb Steve A., Zarychanski Ryan, Zuily Stéphane, le Gal Grégoire Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration Journal of thrombosis and haemostasis 2020;18 (11):2958-2967 [PubMed]
• Hamulyák Eva N., Scheres Luuk J. J., Marijnen Mauritia C., Goddijn Mariëtte, Middeldorp Saskia Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss Cochrane database of systematic reviews (Online) 2020;2020 (5) [PubMed]
• Siegal Deborah M., Barnes Geoffrey D., Langlois Nicole J., Lee Adrienne, Middeldorp Saskia, Skeith Leslie, Wood William A., le Gal Grégoire A toolkit for the collection of thrombosis-related data elements in COVID-19 clinical studies Blood advances 2020;4 (24):6259-6273 [PubMed]
• Dujardin Romein W. G., Hilderink Bashar N., Haksteen Wolmet E., Middeldorp S., Vlaar Alexander P. J., Thachil J., Müller Marcella C. A., Juffermans Nicole P. Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients Thrombosis research 2020;196:308-312 [PubMed]
• Kraaijpoel Noémie Cancer-associated thrombosis: Advances in diagnosis and treatmen 2020. 309p. ISBN 9789463757744. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Middeldorp Saskia; Co-supervisors: Buller Harry R., van Es Nick)
• Weitz Jeffrey I., Haas Sylvia, Ageno Walter, Goldhaber Samuel Z., Turpie Alexander G. G., Goto Shinya, Angchaisuksiri Pantep, Nielsen J. rn Dalsgaard, Kayani Gloria, Farjat Alfredo E., Schellong Sebastian, Bounameaux Henri, Mantovani Lorenzo G., Prandoni Paolo, Kakkar Ajay K., Loualidi Ab, Colak Abdurrahim, Bezuidenhout Abraham, Abdool-Carrim Abu, Azeddine Addala, Beyers Adriaan, Dees Adriaan, Mohamed Ahmed, Aksoy Ahmet, Abiko Akihiko, Watanabe Akinori, Krichell Alan, Fernandez Alberto Alfredo, Tosetto Alberto, Khotuntsov Alexey, Oropallo Alisha, Slocombe Alison, Kelly Allan, Clark Amanda, Gad Amr, Arouni Amy, Schmidt Andor, Berni Andrea, Kleiban Andres Javier, Machowski Andrew, Kazakov Andrey, Galvez Angel, Lockman Ann, Falanga Anna, Chauhan Anoop, Riera-Mestre Antoni, Mazzone Antonino, D’Angelo Armando, Middeldorp Saskia, Gerdes Victor Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE Journal of thrombosis and thrombolysis 2020;50 (2):267-277 [PubMed]
• van Engelen Tjitske S. R., Kanglie Maadrika M. N. P., van den Berk Inge A. H., Bouwman Merel L. J., Suhooli Hind J. M., Heckert Sascha L., Stoker Jaap, Bossuyt Patrick M. M., Prins Jan M., Annema Jouke, Beenen Ludo F. M., Bipat Shandra, Bresser Paul, Dijkgraaf Marcel, Donker Jos, van Engelen Tjitske S. R., Frankemölle Betty, Groenink Maarten, Hochheimer Suzanne M. R., Holleman Frits, Hulzebosch Dorine, Keijzers Mitran, van der Lee Ivo, Leenhouts Peter, Luitse Jan, Meijboom Lilian J., Middeldorp Saskia, Montauban van Swijndregt Alexander, de Monyé Wouter, Otker Jacqueline, Ridderikhof Milan, Romijn Johannes A., Schoonderwoerd Antoinet J. N., Sprengers Ralf W., Taal Elizabeth M., Winter Michiel Classifying the diagnosis of study participants in clinical trials: a structured and efficient approach European Radiology Experimental 2020;4 (1) [PubMed]
• Mulder Frits I., di Nisio Marcello, Ay Cihan, Carrier Marc, Bosch Floris T. M., Segers Annelise, Kraaijpoel Noémie, Grosso Michael A., Zhang George, Verhamme Peter, Wang Tzu-Fei, Weitz Jeffrey I., Middeldorp Saskia, Raskob Gary, Beenen Ludo F. M., Büller Harry R., van Es Nick Clinical implications of incidental venous thromboembolism in cancer patients European respiratory journal 2020;55 (2) [PubMed]
• Wiegers Hanke M. G., Middeldorp Saskia Contemporary best practice in the management of pulmonary embolism during pregnancy Therapeutic advances in respiratory disease 2020;14 [PubMed]
• Mulder F. I., van Es N., Kraaijpoel N., di Nisio M., Carrier M., Duggal A., Gaddh M., Garcia D., Grosso M. A., Kakkar A. K., Mercuri M. F., Middeldorp S., Royle G., Segers A., Shivakumar S., Verhamme P., Wang T., Weitz J. I., Zhang G., Büller H. R., Raskob G. Corrigendum to “Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study” [Thromb. Res. vol. 185, January 2020, pages 13–19] (Thrombosis Research (2020) 185 (13–19), (S0049384819304931), (10.1016/j.thromres.2019.11.007)) Thrombosis research 2020;191:156-159 [PubMed]
• Hendriks Stephan V., Bavalia Roisin, van Bemmel Thomas, Bistervels Ingrid M., Eijsvogel Michiel, Faber Laura M., Fogteloo Jaap, Hofstee Herman M. A., van der Hulle Tom, Iglesias del Sol Antonio, Kruip Marieke J. H. A., Mairuhu Albert T. A., Middeldorp Saskia, Nijkeuter Mathilde, Huisman Menno V., Klok Frederikus A. Current practice patterns of outpatient management of acute pulmonary embolism: A post-hoc analysis of the YEARS study Thrombosis research 2020;193:60-65 [PubMed]
• van Doorn Peter, Rosing Jan, Campello Elena, Middeldorp Saskia, Simioni Paolo, Meijers Joost C. M., Hackeng Tilman M., Castoldi Elisabetta Development of a Plasma-Based Assay to Measure the Susceptibility of Factor V to Inhibition by the C-Terminus of TFPIα Thrombosis and haemostasis 2020;120 (1):55-64 [PubMed]
• Mulder Frits I., Bosch Floris T.M., Young Annie M., Marshall Andrea, McBane Robert D., Zemla Tyler J., Carrier Marc, Kamphuisen Pieter Willem, Bossuyt Patrick M.M., Büller Harry R., Weitz Jeffrey I., Middeldorp Saskia, van Es Nick Direct oral anticoagulants for cancer-associated venous thromboembolism: a systematic review and meta-analysis Blood 2020;136 (12):1433-1441 [PubMed]
• Mulder F. I., van Es N., Kraaijpoel N., di Nisio M., Carrier M., Duggal A., Gaddh M., Garcia D., Grosso M. A., Kakkar A. K., Mercuri M. F., Middeldorp S., Royle G., Segers A., Shivakumar S., Verhamme P., Wang T., Weitz J. I., Zhang G., Büller H. R., Raskob G. Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study Thrombosis research 2020;185:13-19 [PubMed]
• Bavalia Roisin, Abdoellakhan Rahat, Brinkman Herm Jan M, Brekelmans Marjolein P A, Hamulyák Eva N, Zuurveld Marleen, Hutten Barbara A, Westerweel Peter E, Olie Renske H, Ten Cate Hugo, Kruip Marieke, Middeldorp Saskia, Meijer Karina, Coppens Michiel Emergencies on direct oral anticoagulants: Management, outcomes, and laboratory effects of prothrombin complex concentrate Research and practice in thrombosis and haemostasis 2020;4 (4):569-581 [PubMed]
• Beenen L. F. M., Bos L. D., Scheerder M. J., Lobé N. H. J., Muller M. C. A., Schultz M. J., van den Aardweg J. G., Goorhuis A., Bonta P. I., Middeldorp S., Vlaar A. P. Extensive pulmonary perfusion defects compatible with microthrombosis and thromboembolic disease in severe Covid-19 pneumonia Thrombosis research 2020;196:135-137 [PubMed]
• Middeldorp Saskia, Ganzevoort Wessel How I treat venous thromboembolism in pregnancy Blood 2020;136 (19):2133-2142 [PubMed]
• Schreiber Karen, Sciascia Savino, Bruce Ian N., Giles Ian, Cuadrado Maria J., Cohen Hannah, Gordon Caroline, Isenberg David, Jacobsen S. ren, Middeldorp Saskia, Mosca Marta, Pavord Sue, Radin Massimo, Roccatello Dario, Salmon Jane, Vinet Evélyne, Voss Anne, Watkins Linda, Hunt Beverley J. Hydroxychloroquine in patients with rheumatic diseases during the COVID-19 pandemic: a letter to clinicians The Lancet Rheumatology 2020;2 (12):e735-e736
• Scheres Luuk J. J., Lijfering Willem M., Groenewegen Norbert F. M., Koole Sanne, de Groot Christianne J. M., Middeldorp Saskia, Cannegieter Suzanne C. Hypertensive Complications of Pregnancy and Risk of Venous Thromboembolism Hypertension 2020;75 (3):781-787 [PubMed]
• Middeldorp Saskia, Coppens Michiel, van Haaps Thijs F., Foppen Merijn, Vlaar Alexander P., Müller Marcella C. A., Bouman Catherine C. S., Beenen Ludo F. M., Kootte Ruud S., Heijmans Jarom, Smits Loek P., Bonta Peter I., van Es Nick Incidence of venous thromboembolism in hospitalized patients with COVID-19 Journal of thrombosis and haemostasis 2020;18 (8):1995-2002 [PubMed]
• Leader Avi, Hamulyák Eva N., Carney Brian J., Avrahami Maya, Knip Jelijn J., Rozenblatt Shira, Beenen Ludo F. M., Yust-Katz Shlomit, Icht Oded, Coppens Michiel, Raanani Pia, Middeldorp Saskia, Büller Harry R., Zwicker Jeffrey I., Spectre Galia Intracranial hemorrhage with direct oral anticoagulants in patients with brain metastases Blood advances 2020;4 (24):6291-6297 [PubMed]
• Wiercioch Wojtek, Nieuwlaat Robby, Akl Elie A., Kunkle Robert, Alexander Kendall E., Cuker Adam, Rajasekhar Anita, Alonso-Coello Pablo, Anderson David R., Bates Shannon M., Cushman Mary, Dahm Philipp, Guyatt Gordon, Iorio Alfonso, Lim Wendy, Lyman Gary H., Middeldorp Saskia, Monagle Paul, Mustafa Reem A., Neumann Ignacio, Ortel Thomas L., Rochwerg Bram, Santesso Nancy, Vesely Sara K., Witt Daniel M., Schünemann Holger J. Methodology for the American Society of Hematology VTE guidelines: Current best practice, innovations, and experiences Blood advances 2020;4 (10):2351-2365 [PubMed]
• Bavalia Roisin, Abdoellakhan Rahat, Beenen Ludo F., Brekelmans M. P. A., Olie Renske H., ten Cate Hugo, Huisman Menno V., Kruip Marieke, Middeldorp Saskia, Meijer Karina, Hutten Barbara A., Coppens Michiel Outcome of intracranial bleeding managed with prothrombin complex concentrate in patients on direct factor Xa inhibitors or vitamin K antagonists Thrombosis research 2020;196:404-409 [PubMed]
• Post R., Tjerkstra M. A., Middeldorp S., van den Berg R., Roos Y. B. W. E. M., Coert B. A., Verbaan D., Vandertop W. P. Platelet transfusion in patients with aneurysmal subarachnoid hemorrhage is associated with poor clinical outcome Scientific reports 2020;10 (1) [PubMed]
• Bosch Floris T. M., Mulder Frits I., Willem Kamphuisen Pieter, Middeldorp Saskia, Bossuyt Patrick M., Büller Harry R., van Es Nick Primary thromboprophylaxis in ambulatory cancer patients with a high Khorana score: a systematic review and meta-analysis Blood advances 2020;4 (20):5215-5225 [PubMed]
• Beenen Ludo F M, Scheres Luuk J J, Stoker Jaap, Middeldorp Saskia Prognostic characteristics and body mass index in patients with pulmonary embolism: does size matter? ERJ open research 2020;6 (1) [PubMed]
• Hamulyák Eva N., de Jong Paulien G., Scheres Luuk J. J., Ewington Lauren J., Middeldorp Saskia, Quenby Siobhan, Goddijn Mariëtte Progress of the ALIFE2 study: A dynamic road towards more evidence Thrombosis research 2020;190:39-44 [PubMed]
• Beyer-Westendorf Jan, Tittl Luise, Bistervels Ingrid, Middeldorp Saskia, Schaefer Christof, Paulus Wolfgang, Thomas Will, Kemkes-Matthes Bettina, Marten Sandra, Bornhauser Martin Safety of direct oral anticoagulant exposure during pregnancy: a retrospective cohort study Lancet. Haematology 2020;7 (12):e884-e891 [PubMed]
• van Es J., Cheung Y. W., van Es N., Klok F. A., Dronkers C. E. A., ten Wolde M., Kruip M. J. H. A., Huisman M. V., Meijer K., Kamphuisen P. W., Gerdes V. E. A., Middeldorp S. Short-term prognosis of breakthrough venous thromboembolism in anticoagulated patients Thrombosis research 2020;187:125-130 [PubMed]
• Meun Cindy, Gunning Marlise N., Louwers Yvonne V., Peters Henrike, Roos-Hesselink Jolien, Roeters van Lennep Jeanine, Rueda Ochoa Oscar-Leonel, Appelman Yolande, Lambalk Nils, Boersma Eric, Kavousi Maryam, Fauser Bart C. JM, Laven Joop S. E., Baart Sara, Benschop Laura, Brouwers Laura, Budde Ricardo, Cannegieter Suzanne, Dam Veerle, Eijkemans Rene, Ferrari Michel, Franx Arie, de Groot Christianne, Hoek Annemieke, Koffijberg Erik, Koster Wendy, Kruit Mark, Lagerweij Giske, Linstra Katie, van der Lugt Aad, Maas Angela, Maassen van den Brink Antoinette, Middeldorp Saskia, Moons Karel G. M., van Rijn Bas, Scheres Luuk, van der Schouw Yvonne T., Steegers Eric, Steegers Regine, Terwindt Gisela, Velthuis Birgitta, Wermer Marieke, Zick Bart, Zoet Gerbrand The cardiovascular risk profile of middle-aged women with polycystic ovary syndrome Clinical endocrinology 2020;92 (2):150-158 [PubMed]
• Mulder F. I., Hovenkamp A., van Laarhoven H. W. M., Büller H. R., Kamphuisen P. W., Hulshof M. C. C. M., van Berge Henegouwen M. I., Middeldorp S., van Es N. Thromboembolic and bleeding complications in patients with oesophageal cancer British journal of surgery 2020;107 (10):1324-1333 [PubMed]
• Jara-Palomares Luis, Solier-López Aurora, Russo Mariaconcetta, Suñer Marta, González-Roncero Francisco, Peters-Sengers Hessel, Middeldorp Saskia, Bemelman Frederike J., Barco Stefano Thromboprophylaxis after renal transplantation and patient risk stratification: The case of mTOR inhibitors Thrombosis research 2020;195:100-102 [PubMed]
• Connors Jean M., Middeldorp Saskia Transgender health and haematology—a matter of respect Lancet. Haematology 2020;7 (5):e367 [PubMed]
• Bavalia Roisin, Middeldorp Saskia, Weisser Gerhard, Espinola-Klein Christine Treatment of Venous Thromboembolism in Special Populations with Direct Oral Anticoagulants Thrombosis and haemostasis 2020;120 (6):899-911 [PubMed]
• Hamulyák Eva N., Brockmeier Austin J., Killas Johanna D., Ananiadou Sophia, Middeldorp Saskia, Leroi Armand M. Women's health in The BMJ: a data science history BMJ open 2020;10 (10):e039759 [PubMed]

2019

• Meijers Joost C. M., Middeldorp Saskia An anticoagulant that does not cause bleeding – an abrupt stop on the road to the Holy Grail Journal of thrombosis and haemostasis 2019;17 (12):2019-2021 [PubMed]
• Gunning Marlise N., Meun Cindy, van Rijn Bas B., Maas Angela H. E. M., Benschop Laura, Franx Arie, Boersma Eric, Budde Ricardo P. J., Appelman Yolande, Lambalk Cornelis B., Eijkemans Marinus J. C., Velthuis Birgitta K., Laven Joop S. E., Fauser Bart C. J. M., Baart Sara, Brouwers Laura, Cannegieter Suzanne, Dam Veerle, Daan Nadine, Eijkemans Rene, Ferrari Michel, de Groot Christianne, Hoek Annemieke, Koffijberg Erik, Koster Wendy, Kruit Mark, Lagerweij Giske, Lambalk Nils, Linstra Katie, van der Lugt Aad, van den Brink Antoinette Maassen, Middeldorp Saskia, Moons Karel, van Lennep Jeanine Roeters, Roos-Hesselink Jolien, Scheres Luuk, van der Schouw Yvonne, Steegers Eric, Steegers Regine, Terwindt Gisela, Wermer Marieke, Zick Bart, Zoet Gerbrand Coronary artery calcification in middle-aged women with premature ovarian insufficiency Clinical endocrinology 2019;91 (2):314-322 [PubMed]
• Horjus Deborah L, Bokslag Anouk, Hooijberg Femke, Hutten Barbara A, Middeldorp Saskia, de Groot Christianne J M Creatine kinase and blood pressure in women with a history of early-onset preeclampsia Pregnancy hypertension 2019;15:118-122 [PubMed]
• Horjus D. J. Creatine kinase and cardiovascular disease 2019. 197p. ISBN 9789090311852. [UvA Dissertations Online] (Supervisors: Middeldorp S. , Sturk A.; Co-supervisor: Nieuwland R.)
• Horjus Deborah L., Bokslag Anouk, Hutten Barbara A., Van Den Born Bert Jan H., Middeldorp Saskia, Vrijkotte Tanja G.M. Creatine kinase is associated with blood pressure during pregnancy Journal of hypertension 2019;37 (7):1467-1474 [PubMed]
• Tardy Bernard, Chalayer Emilie, Kamphuisen Pieter Willem, Ni Ainle Fionnuala, Verhamme Peter, Varlet Marie Noelle, Chauleur Celine, Rodger Marc, Merah Adel, Buchmuller Andrea, Bistervels Ingrid, de Sancho Maria T., Middeldorp Saskia, Bertoletti Laurent Definition of bleeding events in studies evaluating prophylactic antithrombotic therapy in pregnant women: A systematic review and a proposal from the ISTH SSC Journal of thrombosis and haemostasis 2019;17 (11):1979-1988 [PubMed]
• Scheres Luuk J. J., van Hylckama Vlieg Astrid, Ballieux Bart E. P. B., Fauser Bart C. J. M., Rosendaal Frits R., Middeldorp Saskia, Cannegieter Suzanne C. Endogenous sex hormones and risk of venous thromboembolism in young women Journal of thrombosis and haemostasis 2019;17 (8):1297-1304 [PubMed]
• Scheres Luuk J. J., Bistervels Ingrid M., Middeldorp Saskia Everything the clinician needs to know about evidence-based anticoagulation in pregnancy Blood reviews 2019;33:82-97 [PubMed]
• Anas Adam A., Prins Jan M., Bode Nausicaa, de Vries Henry J. C., Middeldorp Saskia, Grobusch Martin P. Fever and a rapidly progressive skin ulcer after a visit to Morocco: A diagnostic challenge Travel medicine and infectious disease 2019;31 [PubMed]
• Connolly S. J., Crowther M., Eikelboom J. W., Gibson C. M., Curnutte J. T., Lawrence J. H., Yue P., Bronson M. D., Lu G., Conley P. B., Verhamme P., Schmidt J., Middeldorp S., Cohen A. T., Beyer-Westendorf J., Albaladejo P., Lopez-Sendon J., Demchuk A. M., Pallin D. J., Concha M., Goodman S., Leeds J., Souza S., Siegal D. M., Zotova E., Meeks B., Ahmad S., Nakamya J., Milling T. J. Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors New England journal of medicine 2019;380 (14):1326-1335 [PubMed]
• Silvis Suzanne M., Lindgren Erik, Hiltunen Sini, Devasagayam Sharon, Scheres Luuk J., Jood Katarina, Zuurbier Susanna M., Kleinig Timothy J., Silver Frank L., Mandell Daniel M., Middeldorp Saskia, Putaala Jukka, Cannegieter Suzanne C., Tatlisumak Turgut, Coutinho Jonathan M. Postpartum Period Is a Risk Factor for Cerebral Venous Thrombosis Stroke; a journal of cerebral circulation 2019;50 (2):501-503 [PubMed]
• van der Pol Liselotte M., Tromeur Cecile, Bistervels Ingrid M., Ni Ainle Fionnuala, van Bemmel Thomas, Bertoletti Laurent, Couturaud Francis, van Dooren Yordi P. A., Elias Antoine, Faber Laura M., Hofstee Herman M. A., van der Hulle Tom, Kruip Marieke J. H. A., Maignan Maxime, Mairuhu Albert T. A., Middeldorp Saskia, Nijkeuter Mathilde, Roy Pierre-Marie, Sanchez Olivier, Schmidt Jeannot, ten Wolde Marije, Klok Frederikus A., Huisman Menno V., Pernod Gilles, Fogteloo A. J., Kroft L. J. M., van der Wall S. J., Beenen L. F. M., Veen C. S. B., Hannigsberg J., Merviel P., Nonent M., Buchmuller A., Chauleur C., Meyer G., Planquette B., Dessole L., Moumneh T., Elias M., Kent E., Breen A., Kevane B., ten Cate H., Hamulyak K. Pregnancy-adapted YEARS algorithm for diagnosis of suspected pulmonary embolism New England journal of medicine 2019;380 (12):1139-1149 [PubMed]
• van der Pol Liselotte M., Tromeur Cecile, Bistervels Ingrid M., Ni Ainle Fionnuala, van Bemmel Thomas, Bertoletti Laurent, Couturaud Francis, van Dooren Yordi P. A., Elias Antoine, Faber Laura M., Hofstee Herman M. A., van der Hulle Tom, Kruip Marieke J. H. A., Maignan Maxime, Mairuhu Albert T. A., Middeldorp Saskia, Nijkeuter Mathilde, Roy Pierre-Marie, Sanchez Olivier, Schmidt Jeannot, ten Wolde Marije, Klok Frederikus A., Huisman Menno V. Pregnancy-adapted YEARS algorithm for diagnosis of suspected pulmonary embolism Obstetrical & gynecological survey 2019;74 (8):460-462
• Scheres Luuk J. J. Sex, hormones & clots: Sex-specific mechanisms and women-specific models for risk assessment & management in thrombosis 2019. 331p. ISBN 9789463753760. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp s. , Cannegieter S. C.; Co-supervisor: Lijfering W. M.)
• Bistervels Ingrid M., Scheres Luuk J. J., Hamulyák Eva N., Middeldorp Saskia Sex matters: Practice 5P's when treating young women with venous thromboembolism Journal of thrombosis and haemostasis 2019;17 (9):1417-1429 [PubMed]
• Skeith Leslie, le Gal Grégoire, de Vries Johanna I. P., Middeldorp Saskia, Goddijn Mariëtte, Kaaja Risto, Gris Jean-Christophe, Martinelli Ida, Schleußner Ekkehard, Petroff David, Langlois Nicole, Rodger Marc A. The risk of cesarean delivery after labor induction among women with prior pregnancy complications: a subgroup analysis of the AFFIRM study BMC pregnancy and childbirth 2019;19 (1):455 [PubMed]
• Karamat Fares A. The role of creatine kinase in hypertension: Therapeutic perspectives 2019. 150p. ISBN 9789402816891. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van Bavel E. T. , Middeldorp S.; Co-supervisor: Brewster L. M.)
• Tardy Bernard, Buchmuller Andrea, Bistervels Ingrid M., Ni Ainle Fionnuala, Middeldorp Saskia Thromboprophylaxis in pregnant women: For whom and which LMWH dosage? Journal of thrombosis and haemostasis 2019;17 (8):1401-1403 [PubMed]
• Connors Jean M., Middeldorp Saskia Transgender patients and the role of the coagulation clinician Journal of thrombosis and haemostasis 2019;17 (11):1790-1797 [PubMed]
• Ende-Verhaar Yvonne M., Meijboom Lilian J., Kroft Lucia J. M., Beenen Ludo F. M., Boon Gudula J. A. M., Middeldorp Saskia, Nossent Esther J., Symersky Petr, Huisman Menno V., Bogaard Harm Jan, Noordegraaf Anton Vonk, Klok Frederikus A. Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study Journal of heart and lung transplantation 2019;38 (7):731-738 [PubMed]
• Klaassen Irene L. M. Venous thromboembolic disease in pediatric malignancies: Epidemiology and prevention 2019. 239p. ISBN 9789463752541. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp S. , Fijnvandraat C. J.; Co-supervisors: van Ommen C. H. , van de Wetering M. D.)

2018

• Scheres L. J. J., Brekelmans M. P. A., Ageno W., Ay C., Büller H. R., Eichinger S., Hutten B. A., Klok F. A., Middeldorp S., Schreiber K., Stach K., Blondon M., Delluc A. Abnormal vaginal bleeding in women of reproductive age treated with edoxaban or warfarin for venous thromboembolism: a post hoc analysis of the Hokusai-VTE study BJOG 2018;125 (12):1581-1589 [PubMed]
• Vlijm-Kievit Anniek, Jorna Nori G. E., Moll Etelka, Pajkrt Eva, Pals Steven T., Middeldorp Saskia, Biemond Bart J., Zeerleder Sacha S., Tio Marieke A., Kemper E. Marleen, Hazenberg Mette D. Acute lymphoblastic leukemia during the third trimester of pregnancy Leukemia & lymphoma 2018;59 (5):1274-1276 [PubMed]
• Bates Shannon M., Rajasekhar Anita, Middeldorp Saskia, McLintock Claire, Rodger Marc A., James Andra H., Vazquez Sara R., Greer Ian A., Riva John J., Bhatt Meha, Schwab Nicole, Barrett Danielle, LaHaye Andrea, Rochwerg Bram American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy Blood advances 2018;2 (22):3317-3359 [PubMed]
• Silvis S. M., Hiltunen S., Lindgren E., Jood K., Zuurbier S. M., Middeldorp S., Putaala J., Cannegieter S. C., Tatlisumak T., Coutinho J. M. Cancer and risk of cerebral venous thrombosis: a case-control study Journal of thrombosis and haemostasis 2018;16 (1):90-95 [PubMed]
• Amin E. E., Joore M. A., ten Cate H., Meijer K., Tick L. W., Middeldorp S., Mostard G. J. M., ten Wolde M., van den Heiligenberg S. M., van Wissen S., van de Poel M. H. W., Villalta S., Serné E. H., Otten H. M., Klappe E. H., Prandoni P., ten Cate-Hoek A. J. Clinical and economic impact of compression in the acute phase of deep vein thrombosis Journal of thrombosis and haemostasis 2018;16 (8):1555-1563 [PubMed]
• Kraaijpoel Noémie, van Es Nick, Bleker Suzanne M., Brekelmans Marjolein P. A., Eerenberg Elise S., Middeldorp Saskia, Cohen Alexander T., Raskob Gary E., Büller Harry R. Clinical Impact and Course of Anticoagulant-Related Major Bleeding in Cancer Patients Thrombosis and haemostasis 2018;118 (1):174-181 [PubMed]
• Kraaijpoel Noémie, di Nisio Marcello, Mulder Frits I., van Es Nick, Beyer-Westendorf Jan, Carrier Marc, Garcia David, Grosso Michael, Kakkar Ajay K., Mercuri Michele F., Middeldorp Saskia, Hernandez Cristhiam Rojas, Santamaria Amparo, Schwocho Lee, Segers Annelise, Verhamme Peter, Wang Tzu-Fei, Weitz Jeffrey I., Zhang George, Zwicker Jeffrey I., Büller Harry R., Raskob Gary E. Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study Thrombosis and haemostasis 2018;118 (8):1439-1449 [PubMed]
• Raskob Gary E., van Es Nick, Verhamme Peter, Carrier Marc, Di Nisio Marcello, Garcia David, Grosso Michael A., Kakkar Ajay K., Kovacs Michael J., Mercuri Michele F., Meyer Guy, Segers Annelise, Shi Minggao, Wang Tzu-Fei, Yeo Erik, Zhang George, Zwicker Jeffrey I., Weitz Jeffrey I., Büller Harry R., Beyer-Westendorf Jan, Boda Zoltan, Chlumsky Yaromir, Gibbs Harry, Kamphuizen P. W., Monreal Manuel, Ockleford Paul, Pabinger-Fasching Ingrid, Sinnaeve Peter, Beenen Ludo, Gerdes Victor, Laleman Wim, Larrey Dominiqe, van Mechelen Rob, Roos Yvo, Scheerder Maeke, Slagboom Ton, Thijs Vincent, Eikelboom John W., Crowther Mark, Roberts Robin S., Vanassche Thomas, Vandenbriele Christophe, Debaveye Barbara, Dani Vidhi, Schwocho Lee, Duggal Anil, Baker R., Carroll P., Kuijer P., Middeldorp S. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism New England journal of medicine 2018;378 (7):615-624 [PubMed]
• Ünlü Betül, van Es Nick, Arindrarto Wibowo, Kiełbasa Szymon M., Mei Hailiang, Westerga Johan, Middeldorp Saskia, Kuppen Peter J. K., Otten Hans-Martin, Cannegieter Suzanne, Versteeg Henri H. Genes associated with venous thromboembolism in colorectal cancer patients Journal of thrombosis and haemostasis 2018;16 (2):293-302 [PubMed]
• ten Cate-Hoek Arina J., Amin Elham E., Bouman Annemieke C., Meijer Karina, Tick Lidwine W., Middeldorp Saskia, Mostard Guy J. M., ten Wolde Marije, van den Heiligenberg Simone M., van Wissen Sanne, van de Poel Marlène H. W., Villalta Sabina, Serné Erik H., Otten Hans-Martin, Klappe Edith H., Bistervels Ingrid M., Lauw Mandy N., Piersma-Wichers Margriet, Prandoni Paolo, Joore Manuela A., Prins Martin H., ten Cate Hugo, Nijziel Martin R., Cheung Y. Whitney, Vedovetto Valentina Individualised versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome (IDEAL DVT): a multicentre, randomised, single-blind, allocation-concealed, non-inferiority trial Lancet. Haematology 2018;5 (1):e25-e33 [PubMed]
• Amin Elham E., ten Cate-Hoek Arina J., Bouman Annemieke C., Meijer Karina, Tick Lidwine, Middeldorp Saskia, Mostard Guy, ten Wolde Marije, van den Heiligenberg Simone, van Wissen Sanne, van de Poel Marlene, Villalta Sabina, Serné Erik, Otten Hans Martin, Klappe Edith, Prandoni Paolo, Prins Martin H., ten Cate Hugo, Joore Manuela A. Individually shortened duration versus standard duration of elastic compression therapy for prevention of post-thrombotic syndrome: a cost-effectiveness analysis Lancet. Haematology 2018;5 (11):e512-e519 [PubMed]
• Rodger Marc, Langlois Nicole, Middeldorp Saskia, Kahn Susan, Sandset Per Morten, Brighton Timothy, Huisman Menno, Meyer Guy, Konstantinides Stavros, Ageno Walter, Morange Pierre, Garcia David, Kreuziger Lisa Baumann, Young Laura, Key Nigel, Monreal Manuel, Jiménez David Initial strides for invent-VTE: Towards global collaboration to accelerate clinical research in venous thromboembolism Thrombosis research 2018;163:128-131 [PubMed]
• van der Pol Liselotte M., Bistervels Ingrid M., van Mens Thijs E., van der Hulle Tom, Beenen Ludo F. M., den Exter Paul L., Kroft Lucia J. M., Mairuhu Albert T. A., Middeldorp Saskia, van Werkhoven Jaap M., ten Wolde Marije, Huisman Menno V., Klok Frederikus A. Lower prevalence of subsegmental pulmonary embolism after application of the YEARS diagnostic algorithm British journal of haematology 2018;183 (4):629-635 [PubMed]
• Scheres Luuk J J, Lijfering Willem M, Middeldorp Saskia, Cheung Yuk W, Barco Stefano, Cannegieter Suzanne C, Coppens Michiel Measurement of coagulation factors during rivaroxaban and apixaban treatment: Results from two crossover trials Research and practice in thrombosis and haemostasis 2018;2 (4):689-695 [PubMed]
• Zoet Gerbrand A., Benschop Laura, Boersma Eric, Budde Ricardo P. J., Fauser Bart C. J. M., van der Graaf Yolanda, de Groot Christianne J. M., Maas Angela H. E. M., Roeters van Lennep Jeanine E., Steegers Eric A. P., Visseren Frank L., van Rijn Bas B., Velthuis Birgitta K., Franx Arie, Appelman Yolande E., Baart Sara J., Brouwers Laura, Cannegieter Suzanne C., Dam Veerle, Eijkemans M. C. J., Ferrari Michel D., Gunning Marlise N., Hoek Annemieke, Koffijberg Erik, Koster M. P. H., Kruit Mark, Lagerwij Giske R., Lambalk C. B., Laven Joop S., Linstra Katie, van der Lugt Aad, van den Brink Antoinette Maassen, Meun Cindy, Middeldorp Saskia, Moons Karel G. M., Roos-Hesselink Jolien W., Scheres Luuk J. J., Steegers-Theunissen Regine P. M., Terwindt Gisela M., Wermer Marieke J. H. Prevalence of subclinical coronary artery disease assessed by coronary computed tomography angiography in 45- to 55-year- old women with a history of preeclampsia Circulation 2018;137 (8):877-879 [PubMed]
• Beenen Ludo F. M., Bossuyt Patrick M. M., Stoker Jaap, Middeldorp Saskia Prognostic value of cardiovascular parameters in computed tomography pulmonary angiography in patients with acute pulmonary embolism European respiratory journal 2018;52 (1) [PubMed]
• Amin Elham E., Bistervels Ingrid M., Meijer Karina, Tick Lidwine W., Middeldorp Saskia, Mostard Guy, van de Poel Marlène, Serné Erik H., Otten Hans M., Klappe Edith M., Joore Manuela A., ten Cate Hugo, ten Wolde Marije, ten Cate-Hoek Arina J. Reduced incidence of vein occlusion and postthrombotic syndrome after immediate compression for deep vein thrombosis Blood 2018;132 (21):2298-2304 [PubMed]
• Trinchero Alice, Scheres Luuk J. J., Prochaska J. rgen H., Ambaglio Chiara, Wild Philipp S., Middeldorp Saskia, Konstantinides Stavros V., Barco Stefano Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis Thrombosis research 2018;172:74-79 [PubMed]
• van Mens T. E., van der Pol L. M., van Es N., Bistervels I. M., Mairuhu A. T. A., van der Hulle T., Klok F. A., Huisman M. V., Middeldorp S. Sex-specific performance of pre-imaging diagnostic algorithms for pulmonary embolism Journal of thrombosis and haemostasis 2018;16 (5):858-865 [PubMed]
• van Mens Thijs E. The protein C system and venous thromboembolism in reproduction: Pathophysiology, epidemiology and diagnosis 2018. ISBN 9789463323123. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp S., Meijers J. C. M.)
• ten Cate Hugo, Lensing Anthonie W. A., Weitz Jeffrey I., Middeldorp Saskia, Beyer-Westendorf Jan, Kubitza Dagmar, Brighton Timothey, Raskob Gary E., Mismetti Patrick, Prandoni Paolo, Gebel Martin, Prins Martin H. The prothrombin time does not predict the risk of recurrent venous thromboembolism or major bleeding in rivaroxaban-treated patients Thrombosis research 2018;170:75-83 [PubMed]
• Di Nisio Marcello, Wichers Iris M., Middeldorp Saskia Treatment for superficial thrombophlebitis of the leg Cochrane database of systematic reviews (Online) 2018;2018 (2):CD004982 [PubMed]
• di Nisio Marcello, Wichers Iris, Middeldorp Saskia Treatment of Lower Extremity Superficial Thrombophlebitis JAMA 2018;320 (22):2367-2368 [PubMed]
• Brekelmans Marjolein P. A. Treatment of venous thromboembolism: focus on patient characteristics and bleeding complications 2018. ISBN 9789462999084. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Middeldorp S.; Co-supervisors: Coppens M., Hutten B. A.)
• Middeldorp Saskia, Ankum Willem M. Venous thromboembolism after induced abortion: the shorter the pregnancy, the lower the risk? Lancet. Haematology 2018;5 (7):e271-e272 [PubMed]

2017

• Brekelmans Marjolein P. A., Scheres Luuk J. J., Bleker Suzanne M., Hutten Barbara A., Timmermans Anne, Büller Harry R., Middeldorp Saskia Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin Thrombosis and haemostasis 2017;117 (4):809-815 [PubMed]
• Barco Stefano, Atema Jasper J., Coppens Michiel, Serlie Mireille J., Middeldorp Saskia Anticoagulants for the prevention and treatment of catheter-related thrombosis in adults and children on parenteral nutrition: a systematic review and critical appraisal Blood transfusion 2017;15 (4):369-377 [PubMed]
• Brekelmans Marjolein P. A., Ginkel Kim van, Daams Joost G., Hutten Barbara A., Middeldorp Saskia, Coppens Michiel Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and meta-analysis Journal of thrombosis and thrombolysis 2017;44 (1):118-129 [PubMed]
• van Es Nick Cancer and thrombosis: Improvements in strategies for prediction, diagnosis, and treatment 2017. 297p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp S., Bossuyt P. M. M.; Co-supervisors: Büller H. R., Di Nisio M.)
• Beyer-Westendorf Jan, Lensing Anthonie W. A., Arya Roopen, Bounameaux Henri, Cohen Alexander T., Wells Philip S., Middeldorp Saskia, Verhamme Peter, Hughes Rodney, Kucher Nils, Pap Akos F., Trajanovic Mila, Prins Martin H., Prandoni Paolo, Weitz Jeffrey I. Choosing wisely: The impact of patient selection on efficacy and safety outcomes in the EINSTEIN-DVT/PE and AMPLIFY trials Thrombosis research 2017;149:29-37 [PubMed]
• van Mens Thijs E., Meijers Joost C. M., Middeldorp Saskia Circulating activated protein C in thrombophilia carriers Journal of thrombosis and thrombolysis 2017;43 (3):361-364 [PubMed]
• Bleker Suzanne M. Clinical aspects of venous thromboembolism in special patient populations 2017. 297p. ISBN 9789462996632. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Middeldorp S.; Co-supervisors: Büller H. R., Di Nisio M.)
• Bleker Suzanne M., Brekelmans Marjolein P. A., Eerenberg Elise S., Cohen Alexander T., Middeldorp Saskia, Raskob Gary, Büller Harry R. Clinical impact of major bleeding in patients with venous thrombo-embolism treated with factor Xa inhibitors or vitamin K antagonists Thrombosis and haemostasis 2017;117 (10):1944-1951 [PubMed]
• Squizzato Alessandro, Bellesini Marta, Takeda Andrea, Middeldorp Saskia, Donadini Marco Paolo Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events Cochrane database of systematic reviews (Online) 2017;2017 (12) [PubMed]
• Horbach S. E. R., Lokhorst M. M., Oduber C. E. U., Middeldorp S., van der Post J. A. M., van der Horst C. M. A. M. Complications of pregnancy and labour in women with Klippel-Trenaunay syndrome: a nationwide cross-sectional study BJOG 2017;124 (11):1780-1788 [PubMed]
• Groom Katie M., McCowan Lesley M., Mackay Laura K., Lee Arier C., Said Joanne M., Kane Stefan C., Walker Susan P., van Mens Thijs E., Hannan Natalie J., Tong Stephen, Chamley Larry W., Stone Peter R., McLintock Claire, Groom K., McCowan L., Mackay L., Lee A., Stone P., Chamley L., McLintock C., Said J., Kane S., Walker S., Tong S., Hannan N., van Mens T., Ganzevoort W., Middeldorp S. Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial American journal of obstetrics and gynecology 2017;216 (3):296.e1-296.e14 [PubMed]
• van Mens T. E., Joensen U. N., Bochdanovits Z., Takizawa A., Peter J., Jørgensen N., Szecsi P. B., Meijers J. C. M., Weiler H., Rajpert-de Meyts E., Repping S., Middeldorp S. Factor V Leiden is associated with increased sperm count Human reproduction (Oxford, England) 2017;32 (11):2332-2339 [PubMed]
• Schreiber Karen, Breen Karen, Cohen Hannah, Jacobsen Soren, Middeldorp Saskia, Pavord Sue, Regan Lesley, Roccatello Dario, Robinson Susan E., Sciascia Savino, Seed Paul T., Watkins Linda, Hunt Beverley J. HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies Seminars in thrombosis and hemostasis 2017;43 (6):562-571 [PubMed]
• van Mens Thijs E., Scheres Luuk J. J., de Jong Paulien G., Leeflang Mariska M. G., Nijkeuter Mathilde, Middeldorp Saskia Imaging for the exclusion of pulmonary embolism in pregnancy Cochrane database of systematic reviews (Online) 2017;2017 (1) [PubMed]
• Rodger Marc A., Gris Jean-Christophe, de Vries Johanna I. P., Martinelli Ida, Rey Evelyne, Schleussner Ekkehard, Middeldorp Saskia, Kaaja Risto, Langlois Nicole J., Ramsay Timothy, Mallick Ranjeeta, Bates Shannon M., Abheiden Carolien N. H., Perna Annalisa, Petroff David, de Jong Paulien, van Hoorn Marion E., Bezemer P. Dick, Mayhew Alain D. Low-Molecular-Weight Heparin and Recurrent Placenta-Mediated Pregnancy Complications: A Meta-analysis of Individual Patient Data From Randomised Controlled Trials Obstetrical & gynecological survey 2017;72 (3):153-155
• Cohen H., Arachchillage D. R., Middeldorp S., Beyer-Westendorf J., Abdul-Kadir R. Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH: reply Journal of thrombosis and haemostasis 2017;15 (1):195-197 [PubMed]
• van der Pol L. M., van der Hulle T., Cheung Y. W., Mairuhu A. T. A., Schaar C. G., Faber L. M., ten Wolde M., Hofstee H. M. A., Hovens M. M. C., Nijkeuter M., van Klink R. C. J., Kruip M. J. H. A., Middeldorp S., Huisman M. V., Klok F. A. No added value of the age-adjusted D-dimer cut-off to the YEARS algorithm in patients with suspected pulmonary embolism Journal of thrombosis and haemostasis 2017;15 (12):2317-2324 [PubMed]
• Klok F. A., Schreiber K., Stach K., Ageno W., Middeldorp S., Eichinger S., Delluc A., Blondon M., Ay C. Oral contraception and menstrual bleeding during treatment of venous thromboembolism: Expert opinion versus current practice: Combined results of a systematic review, expert panel opinion and an international survey Thrombosis research 2017;153:101-107 [PubMed]
• Middeldorp Saskia, Iorio Alfonso Oral contraceptive use is a provoking factor for venous thromboembolism BMJ (Clinical research ed.) 2017;357:j2073 [PubMed]
• Cheung Y. Whitney, Barco Stefano, Mathôt Ron A. A., van den Dool Erik-Jan, Stroobants An K., Serlie Mireille J., Middeldorp Saskia, Coppens Michiel Pharmacokinetics of dabigatran etexilate and rivaroxaban in patients with short bowel syndrome requiring parenteral nutrition: The PDER PAN study Thrombosis research 2017;160:76-82 [PubMed]
• Weitz Jeffrey I., Lensing Anthonie W. A., Prins Martin H., Bauersachs Rupert, Beyer-Westendorf Jan, Bounameaux Henri, Brighton Timothy A., Cohen Alexander T., Davidson Bruce L., Decousus Hervé, Freitas Maria C. S., Holberg Gerlind, Kakkar Ajay K., Haskell Lloyd, van Bellen Bonno, Pap Akos F., Berkowitz Scott D., Verhamme Peter, Wells Philip S., Prandoni Paolo, Bianchi Alessandra, Brighton Tim, Carroll Patrick, Chong Beng, Chunilal Sanjeev, Coughlin Paul, Curnow Jennifer, Jackson David, Tran Huyen, Ward Chris, Brodmann Marianne, Kyrle Paul, Marschang Peter, Petkov Ventzislav, Hainaut Philippe, Jordens Paul, Vandekerkhof Jos, Wautrecht Jean-Claude, Annichino-Bizzacchi Joyce, Correa Joao, Cukier Alberto, Freire Antonio, Pereira Adamastor, Porto Carmen, Sacilotto Roberto, Vasconcelos Costa Agenor, Della Siega Anthony, Dolan Sean, Le Gal Gregoire, Middeldorp Saskia Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism New England journal of medicine 2017;376 (13):1211-1222 [PubMed]
• Barco Stefano, Picchi Chiara, Trinchero Alice, Middeldorp Saskia, Coppens Michiel Safety of prothrombin complex concentrate in healthy subjects British journal of haematology 2017;176 (4):664-666 [PubMed]
• Scheres L. J. J., Brekelmans M. P. A., Beenen L. F. M., Büller H. R., Cannegieter S. C., Middeldorp S. Sex-specific differences in the presenting location of a first venous thromboembolism Journal of thrombosis and haemostasis 2017;15 (7):1344-1350 [PubMed]
• van der Hulle Tom, Cheung Whitney Y., Kooij Stephanie, Beenen Ludo F. M., van Bemmel Thomas, van Es Josien, Faber Laura M., Hazelaar Germa M., Heringhaus Christian, Hofstee Herman, Hovens Marcel M. C., Kaasjager Karin A. H., van Klink Rick C. J., Kruip Marieke J. H. A., Loeffen Rinske F., Mairuhu Albert T. A., Middeldorp Saskia, Nijkeuter Mathilde, van der Pol Liselotte M., Schol-Gelok Suzanne, ten Wolde Marije, Klok Frederikus A., Huisman Menno V., Fogteloo Anne J., Kroft Lucia J. M., Brekelmans Marjolein P., Vermaire René M. J., Bastiaansen-Bergsma Hanny, Biedermann Jossi S., Klijn Adinda, van der Voort Sanne, Lieveld Arthur W. E., de Jong Peter Y., Schaar Cees G., del Sol Antonio Iglesias Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study Lancet 2017;390 (10091):289-297 [PubMed]
• van Es N., Franke V. F., Middeldorp S., Wilmink J. W., Büller H. R. The Khorana score for the prediction of venous thromboembolism in patients with pancreatic cancer Thrombosis research 2017;150:30-32 [PubMed]
• Klaassen Irene L. M., Lauw Mandy N., van de Wetering Marianne D., Biemond Bart J., Middeldorp Saskia, Abbink Floor C. H., Bierings Marc, te Loo D. Maroeska M. W., Pieters Rob, van der Sluis Inge M., Tissing Wim J. E., Zwaan C. Michel, van Ommen C. Heleen TropicALL study: Thromboprophylaxis in Children treated for Acute Lymphoblastic Leukemia with Low-molecular-weight heparin: a multicenter randomized controlled trial BMC pediatrics 2017;17 (1) [PubMed]
• Amraoui Fouad Vascular damage and dysfunction in hypertensive emergencies 2017. 188p. ISBN 9789462335301. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp S., van der Post J. M.; Co-supervisors: van den Born B. J. H., Vogt L.)
• Cunha Marisa L. R., Meijers Joost C. M., Rosendaal Frits R., Vlieg Astrid van Hylckama, Reitsma Pieter H., Middeldorp Saskia Whole exome sequencing in thrombophilic pedigrees to identify genetic risk factors for venous thromboembolism PLoS ONE 2017;12 (11) [PubMed]

2016

• Connolly Stuart J., Milling Truman J., Eikelboom John W., Gibson C. Michael, Curnutte John T., Gold Alex, Bronson Michele D., Lu Genmin, Conley Pamela B., Verhamme Peter, Schmidt Jeannot, Middeldorp Saskia, Cohen Alexander T., Beyer-Westendorf Jan, Albaladejo Pierre, Lopez-Sendon Jose, Goodman Shelly, Leeds Janet, Wiens Brian L., Siegal Deborah M., Zotova Elena, Meeks Brandi, Nakamya Juliet, Lim W. Ting, Crowther Mark, Connolly S. C., Crowther M., Eikelboom J., Gibson M., Milling T. J., Albaladejo P., Cohen A., Lopez-Sendon J., Schmidt J., Verhamme P., Beyer-Westendorf J., Wyse D. G., Garcia D., Prins M. [=Martin H.], Nakamya J., Büller H. R., Mahaffey K., Alexander J., Demchuk A., Raskob G., Schulman S., Meeks B., Zotova E., Holadyk-Gris I., Coppens M. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors New England journal of medicine 2016;375 (12):1131-1141 [PubMed]
• Heestermans Marco, Cunha Marisa L. R., Reitsma Pieter H., Zeerleder Sacha S., Middeldorp Saskia, van Vlijmen Bart J. M. Circulating nucleosomes and elastase α1-antitrypsin complexes and the novel thrombosis susceptibility locus SLC44A2 Thrombosis research 2016;142:8-10 [PubMed]
• Brekelmans Marjolein P. A., Bleker Suzanne M., Bauersachs Rupert, Boda Zoltan, Büller Harry R., Choi Youngsook, Gallus Alex, Grosso Michael A., Middeldorp Saskia, Oh Doyeun, Raskob Gary, Schwocho Lee, Cohen Alexander T. Clinical impact and course of major bleeding with edoxaban versus vitamin K antagonists Thrombosis and haemostasis 2016;116 (1):155-161 [PubMed]
• Bleker Suzanne M., Cohen Alexander T., Büller Harry R., Agnelli Giancarlo, Gallus Alexander S., Raskob Gary E., Weitz Jeffrey I., Curto Madelyn, Sisson Melanie, Middeldorp Saskia Clinical presentation and course of bleeding events in patients with venous thromboembolism, treated with apixaban or enoxaparin and warfarin. Results from the AMPLIFY trial Thrombosis and haemostasis 2016;116 (6):1159-1164 [PubMed]
• Cheung Yuk Wah Diagnosis, treatment and long-term effects of venous thromboembolism 2016. 265p. ISBN 9789402803761. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Middeldorp S.; Co-supervisors: ten Wolde M., Coppens M.)
• Cohen Hannah, Arachchillage Deepa R. J., Beyer-Westendorf Jan, Middeldorp Saskia, Kadir Rezan A. Direct Oral Anticoagulants and Women Seminars in thrombosis and hemostasis 2016;42 (7):789-797 [PubMed]
• Lock J., de Bekker-Grob E. W., Urhan G., Peters M., Meijer K., Brons P., van der Meer F. J. M., Driessens M. H. E., Collins P. W., Fijnvandraat K., Leebeek F. W. G., Cnossen M. H., Mathôt R. A. A., Kruip M. H., de Wildt S. N., Polinder S., Ista W. G., Hazendonk H. C. A. M., van Moort I., Steyerberg E. W., Borsboom G. J. J. M., Preijers T., Stokhuijzen E., Coppens M., Middeldorp S., Tamminga R. Y. J., Laros-van Gorkom B. A. P., Eikenboom H. C. J., Schutgens R. E. G., de Meris J., Zwaan C. M., Ramnarain S., Bosschaart-Castermans R. M. M., Rotte A. E., Koolma A., Ammerlaan A. C. J. Facilitating the implementation of pharmacokinetic-guided dosing of prophylaxis in haemophilia care by discrete choice experiment Haemophilia 2016;22 (1):e1-e10 [PubMed]
• Bates Shannon M., Middeldorp Saskia, Rodger Marc, James Andra H., Greer Ian Guidance for the treatment and prevention of obstetric-associated venous thromboembolism Journal of thrombosis and thrombolysis 2016;41 (1):92-128 [PubMed]
• Barco S., Heuschen C. B. B. C. M., Salman B., Brekelmans M. P. A., Serlie M. J., Middeldorp S., Coppens M. Home parenteral nutrition-associated thromboembolic and bleeding events: results of a cohort study of 236 individuals Journal of thrombosis and haemostasis 2016;14 (7):1364-1373 [PubMed]
• Scheres L. J. J., Lijfering W. M., Middeldorp S., Cannegieter S. C. Influence of World Thrombosis Day on digital information seeking on venous thrombosis: a Google Trends study Journal of thrombosis and haemostasis 2016;14 (12):2325-2328 [PubMed]
• Middeldorp Saskia Inherited thrombophilia: a double-edged sword Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2016;2016 (1):1-9 [PubMed]
• Mahmoodi Bakhtawar K., Veeger Nic J. G. M., Middeldorp Saskia, Lijfering Willem M., Brouwer Jan-Leendert P., ten Berg Jur, Hamulyák Karly, Meijer Karina Interaction of Hereditary Thrombophilia and Traditional Cardiovascular Risk Factors on the Risk of Arterial Thromboembolism: Pooled Analysis of Four Family Cohort Studies Circulation. Cardiovascular genetics 2016;9 (1):79-85 [PubMed]
• McLintock C., Pabinger I., Bauer K. A., Laffan M., Angchaisuksiri P., Rezende S. M., Middeldorp S., Ross M. International Society on Thrombosis and Haemostasis core curriculum project: core competencies in clinical thrombosis and hemostasis Journal of thrombosis and haemostasis 2016;14 (1):3-27 [PubMed]
• Barco Stefano, Whitney Cheung Y., Coppens Michiel, Hutten Barbara A., Meijers Joost C. M., Middeldorp Saskia In vivo reversal of the anticoagulant effect of rivaroxaban with four-factor prothrombin complex concentrate British journal of haematology 2016;172 (2):255-261 [PubMed]
• Rodger Marc A., Gris Jean-Christophe, de Vries Johanna I. P., Martinelli Ida, Rey Évelyne, Schleussner Ekkehard, Middeldorp Saskia, Kaaja Risto, Langlois Nicole J., Ramsay Timothy, Mallick Ranjeeta, Bates Shannon M., Abheiden Carolien N. H., Perna Annalisa, Petroff David, de Jong Paulien, van Hoorn Marion E., Bezemer P. Dick, Mayhew Alain D. Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials Lancet 2016;388 (10060):2629-2641 [PubMed]
• Bleker Suzanne M., Buchmüller Andrea, Chauleur Céline, Ní Áinle Fionnuala, Donnelly Jennifer, Verhamme Peter, Jacobsen Anne Flem, Ganzevoort Wessel, Prins Martin, Beyer-Westendorf Jan, DeSancho Maria, Konstantinides Stavros, Pabinger Ingrid, Rodger Marc, Decousus Hervé, Middeldorp Saskia Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses Thrombosis research 2016;144:62-68 [PubMed]
• Cohen H., Arachchillage D. R., Middeldorp S., Beyer-Westendorf J., Abdul-Kadir R. Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH Journal of thrombosis and haemostasis 2016;14 (8):1673-1676 [PubMed]
• Cheung Y. Whitney, Middeldorp Saskia, Prins Martin H., Pap Akos F., Lensing Anthonie W. A., ten Cate-Hoek Arina J., Villalta Sabina, Milan Marta, Beyer-Westendorf Jan, Verhamme Peter, Bauersachs Rupert M., Prandoni Paolo Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin/vitamin K antagonists for acute deep-vein thrombosis A post-hoc analysis Thrombosis and haemostasis 2016;116 (4):733-738 [PubMed]
• Beyer-Westendorf Jan, Michalski Franziska, Tittl Luise, Middeldorp Saskia, Cohen Hannah, Abdul Kadir Rezan, Arachchillage Deepa Jayakody, Arya Roopen, Ay Cihan, Marten Sandra Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting Thrombosis and haemostasis 2016;116 (4):651-658 [PubMed]
• Martinelli Ida, Lensing Anthonie W. A., Middeldorp Saskia, Levi Marcel, Beyer-Westendorf Jan, van Bellen Bonno, Bounameaux Henri, Brighton Timothy A., Cohen Alexander T., Trajanovic Mila, Gebel Martin, Lam Phuong, Wells Philip S., Prins Martin H. Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use Blood 2016;127 (11):1417-1425 [PubMed]
• Silvis Suzanne M., Middeldorp Saskia, Zuurbier Susanna M., Cannegieter Suzanne C., Coutinho Jonathan M. Risk Factors for Cerebral Venous Thrombosis Seminars in thrombosis and hemostasis 2016;42 (6):622-631 [PubMed]
• Zuurbier Susanna M., Arnold Marcel, Middeldorp Saskia, Broeg-Morvay Anne, Silvis Suzanne M., Heldner Mirjam R., Meisterernst Julia, Nemeth Banne, Meulendijks Eva R., Stam Jan, Cannegieter Suzanne C., Coutinho Jonathan M. Risk of Cerebral Venous Thrombosis in Obese Women JAMA Neurology 2016;73 (5):579-584 [PubMed]
• Zuurbier Susanna M., Middeldorp Saskia, Stam Jan, Coutinho Jonathan M. Sex differences in cerebral venous thrombosis: A systematic analysis of a shift over time International journal of stroke 2016;11 (2):164-170 [PubMed]
• Sciascia Savino, Branch D. Ware, Levy Roger A., Middeldorp Saskia, Pavord Sue, Roccatello Dario, Ruiz-Irastorza Guillermo, Tincani Angela, Khamashta Munther, Schreiber Karen, Hunt Beverley J. The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and clinical judgment Thrombosis and haemostasis 2016;115 (2):285-290 [PubMed]
• van Vlijmen E. F. W., Veeger N. J. G. M., Middeldorp S., Hamulyák K., Prins M. H., Kluin-Nelemans H. C., Meijer K. The impact of a male or female thrombotic family history on contraceptive counseling: a cohort study Journal of thrombosis and haemostasis 2016;14 (9):1741-1748 [PubMed]
• Lim Ming Y., Deal Allison M., Kim Steven, Musty Michael D., Conard Jacqueline, Simioni Paolo, Dutrillaux Fabienne, Eid Suhair S., Middeldorp Saskia, Halbmayer Walter M., Boneu Bernard, Moia Marco, Moll Stephan Thrombophilic risk of individuals with rare compound factor V Leiden and prothrombin G20210A polymorphisms: an international case series of 100 individuals European journal of haematology 2016;97 (4):353-360 [PubMed]
• Barco Stefano Thrombosis and anticoagulant treatment in special populations 2016. 293p. ISBN 9789461826572. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Middeldorp S.; Co-supervisor: Coppens M.)

2015

• de Crem Nico, Peerlinck Kathelijne, Vanassche Thomas, Vanheule Kristine, Debaveye Barbara, Middeldorp Saskia, Verhamme Peter, Peetermans Marijke Abnormal uterine bleeding in VTE patients treated with rivaroxaban compared to vitamin K antagonists Thrombosis research 2015;136 (4):749-753 [PubMed]
• de Jong Paulien G., Quenby Siobhan, Bloemenkamp Kitty W. M., Braams-Lisman Babette A. M., de Bruin Jan Peter, Coomarasamy Arri, David Michele, DeSancho Maria T., van der Heijden Olivier W. H., Hoek Annemieke, Hutten Barbara A., Jochmans Kristin, Koks Carolien A. M., Kuchenbecker Walter K. M., Mol Ben Willem J., Torrance Helen L., Scheepers Hubertina C. J., Stephenson Mary D., Verhoeve Harold R., Visser Jantien, de Vries Johanna I. P., Goddijn Mariëtte, Middeldorp Saskia ALIFE2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia--study protocol for a randomized controlled trial Trials 2015;16 (1):208 [PubMed]
• Cunha Marisa L. R., Bakhtiari Kamran, Peter Jorge, Marquart J. Arnoud, Meijers Joost C. M., Middeldorp Saskia A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function Blood 2015;125 (11):1822-1825 [PubMed]
• van Es J., Beenen L. F. M., Douma R. A., den Exter P. L., Mos I. C. M., Kaasjager H. A. H., Huisman M. V., Kamphuisen P. W., Middeldorp S., Bossuyt P. M. M. A simple decision rule including D-dimer to reduce the need for computed tomography scanning in patients with suspected pulmonary embolism Journal of thrombosis and haemostasis 2015;13 (8):1428-1435 [PubMed]
• Coutinho Jonathan M., Zuurbier Susanna M., Gaartman Aafke E., Dikstaal Arienne A., Stam Jan, Middeldorp Saskia, Cannegieter Suzanne C. Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study Stroke; a journal of cerebral circulation 2015;46 (10):2735-2740 [PubMed]
• Zuurbier Susanna M., Lauw Mandy N., Coutinho Jonathan M., Majoie Charles B. L. M., van der Holt Bronno, Cornelissen Jan J., Middeldorp Saskia, Biemond Bart J., Stam Jan Clinical Course of Cerebral Venous Thrombosis in Adult Acute Lymphoblastic Leukemia Journal of stroke and cerebrovascular diseases 2015;24 (7):1679-1684 [PubMed]
• Eerenberg E. S., Middeldorp S., Levi M., Lensing A. W., Büller H. R. Clinical impact and course of major bleeding with rivaroxaban and vitamin K antagonists Journal of thrombosis and haemostasis 2015;13 (9):1590-1596 [PubMed]
• Schut Anne Marieke, Venemans-Jellema Annemarie, Meijers Joost C. M., Middeldorp Saskia, de Groot Philip G., Rosendaal Frits R., Roest Mark, Lisman Ton, Cannegieter Suzanne C. Coagulation activation during air travel is not initiated via the extrinsic pathway British journal of haematology 2015;169 (6):903-905 [PubMed]
• Brekelmans Mpa, Middeldorp S., Coppens M. Direct factor Xa inhibitor edoxaban: from bench to clinical practice Expert review of hematology 2015;8 (6):707-725 [PubMed]
• van der Voort Paul, Pijls Bart G., Nieuwenhuijse Marc J., Jasper Jorrit, Fiocco Marta, Plevier Josepha W. M., Middeldorp Saskia, Valstar Edward R., Nelissen Rob G. H. H. Early subsidence of shape-closed hip arthroplasty stems is associated with late revision. A systematic review and meta-analysis of 24 RSA studies and 56 survival studies Acta orthopaedica 2015;86 (5):575-585 [PubMed]
• Braamskamp Marjet J. A. M., Stefanutti Claudia, Langslet Gisle, Drogari Euridiki, Wiegman Albert, Hounslow Neil, Kastelein John J. P., Kolovou Genovefa, Elisaf Moses, Middeldorp Saskia, García Jiménez Ma Concepción, Ponce Esperanza Castejón, Di Giacomo Serafina, Morozzi Claudia, Pozzi Claudia, Peretti Noel, Thompson Gilbert, McCrindle Brian, Guardamagna Ornella Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk Journal of pediatrics 2015;167 (2):338-+ [PubMed]
• Lauw Mandy Nicole Hypercoagulability in hematological malignancies 2015. 293p. ISBN 9789461697097. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp S., van Oers M. H. J.; Co-supervisor: Biemond B. J.)
• de Jong Paulien Gerdina Inherited thrombophilia and pregnancy complications 2015. 299p. ISBN 9789462597112. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Middeldorp S.; Co-supervisor: Goddijn M.)
• Cunha Marisa L. R., Meijers Joost C. M., Middeldorp Saskia Introduction to the analysis of next generation sequencing data and its application to venous thromboembolism Thrombosis and haemostasis 2015;114 (5):920-932 [PubMed]
• Cheung Y. W., Barco S., Hutten B. A., Meijers J. C. M., Middeldorp S., Coppens M. In vivo increase in thrombin generation by four-factor prothrombin complex concentrate in apixaban-treated healthy volunteers Journal of thrombosis and haemostasis 2015;13 (10):1799-1805 [PubMed]
• Middeldorp Saskia, Hutten Barbara A. Long-term vs Short-term Therapy With Vitamin K Antagonists for Symptomatic Venous Thromboembolism JAMA 2015;314 (1):72-73 [PubMed]
• Klaassen Irene L. M., van Ommen C. Heleen, Middeldorp Saskia Manifestations and clinical impact of pediatric inherited thrombophilia Blood 2015;125 (7):1073-1077 [PubMed]
• Thijs Willemien, Janssen Kirsten, van Schadewijk Annemarie M., Papapoulos Socrates E., le Cessie Saskia, Middeldorp Saskia, Melissant Christian F., Rabe Klaus F., Hiemstra Pieter S. Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment PLoS ONE 2015;10 (11):e0140986 [PubMed]
• Middeldorp Saskia New studies of low-molecular-weight heparin in pregnancy Thrombosis research 2015;135 (Suppl. 1):S26-S29 [PubMed]
• de Jong Paulien G., Hiddink Larissa, Meijers Joost C. M., Kiemeney Lambertus A., van Heerde Waander L., Middeldorp Saskia No association between Annexin A5 genetic variants and deep venous thrombosis British journal of haematology 2015;169 (2):301-304 [PubMed]
• de Boer Anna W., de Mutsert Renée, den Heijer Martin, Jukema Johan W., Rosendaal Frits R., Blom Jeanet W., Assendelft Willem J. J., Middeldorp Saskia, Rabelink Ton J., Smit Johannes W. A., Romijn Johannes A., Rabe Klaus F., de Roos Albert, le Cessie Saskia, Hiemstra Pieter S., Kloppenburg Margreet, Huizinga Ton W. J., Pijl Hanno, Tamsma Jouke T., de Koning Eelco J. P., Reitsma Pieter H., van Dijk Ko Willems, de Vries Aiko P. J., Lamb Hildo J., Jazet Ingrid M., Dekkers Olaf M., Biermasz Nienke R., Cobbaert Christa M., Dekker Jacqueline M., Penninx Brenda W. Overweight can be used as a tool to guide case-finding for cardiovascular risk assessment Family practice 2015;32 (6):646-651 [PubMed]
• Amraoui F., Hassani Lahsinoui H., Boussata S., Keijser R., Veenboer G. J. M., Middeldorp S., van der Post J. A. M., Ris-Stalpers C., Afink G. B., van den Born B. J. H. Placental expression of heparan sulfate 3-O-sulfotransferase-3A1 in normotensive and pre-eclamptic pregnancies Placenta 2015;36 (11):1218-1224 [PubMed]
• Middeldorp Saskia Tromboflebitis: onjuiste conclusies Huisarts en wetenschap 2015;58 (2):114-115

2014

• van Roessel S., Middeldorp S., Cheung Y. W., Zwinderman A. H., de Pont A. C. J. M. Accuracy of aPTT monitoring in critically ill patients treated with unfractionated heparin Netherlands journal of medicine 2014;72 (6):305-310 [PubMed]
• Coutinho J. M., Middeldorp S., Stam J. Advances in the Treatment of Cerebral Venous Thrombosis Current treatment options in neurology 2014;16 (7):299 [PubMed]
• Middeldorp Saskia Anticoagulation in pregnancy complications Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2014;2014 (1):393-399 [PubMed]
• de Jong Paulien G., Kaandorp Stef, Di Nisio Marcello, Goddijn Mariette, Middeldorp Saskia Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia Cochrane database of systematic reviews (Online) 2014;2014 (7):CD004734 [PubMed]
• Lee Dae Hyun, Dane Martijn J. C., van den Berg Bernard M., Boels Margien G. S., van Teeffelen Jurgen W., de Mutsert Renée, den Heijer Martin, Rosendaal Frits R., van der Vlag Johan, van Zonneveld Anton Jan, Vink Hans, Rabelink Ton J., Middeldorp Saskia, Smit Johannes W. A., Romijn Johannes A., Rabe Klaus F., Jukema J. Wouter, de Roos Albert, le Cessie Saskia, Hiemstra Pieter S., Kloppenburg Margreet, Huizinga Ton W. J., Pijl Hanno, Tamsma Jouke T., de Koning Eelco J. P., Assendelft Pim J. J., Reitsma Pieter H., van Dijk Ko Willems, de Vries Aiko P. J., Lamb Hildo J., Jazet Ingrid M., Dekkers Olaf M., Biermasz Nienke R., Cobbaert Christa M., Dekker Jacqueline M., Penninx Brenda W. Deeper Penetration of Erythrocytes into the Endothelial Glycocalyx Is Associated with Impaired Microvascular Perfusion PLoS ONE 2014;9 (5):e96477 [PubMed]
• van Es Nick, Coppens Michiel, Schulman Sam, Middeldorp Saskia, Büller Harry R. Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials Blood 2014;124 (12):1968-1975 [PubMed]
• Middeldorp Saskia, Prins Martin H., Hutten Barbara A. Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism Cochrane database of systematic reviews (Online) 2014;2014 (8):CD001367 [PubMed]
• van Es Nick, Sturk Auguste, Middeldorp Saskia, Nieuwland Rienk Effects of cancer on platelets Seminars in oncology 2014;41 (3):311-318 [PubMed]
• Rodger Marc A., Langlois Nicole J., de Vries Johanna Ip, Rey Evelyne, Gris Jean-Christophe, Martinelli Ida, Schleussner Ekkehard, Ramsay Timothy, Mallick Ranjeeta, Skidmore Becky, Middeldorp Saskia, Bates Shannon, Petroff David, Bezemer Dick, van Hoorn Marion E., Abheiden Carolien Nh, Perna Annalisa, de Jong Paulien, Kaaja Risto Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM) Systematic reviews 2014;3 (1):69 [PubMed]
• Akl Elie A., Kahale Lara A., Ballout Rami A., Barba Maddalena, Yosuico Victor E. D., van Doormaal Frederiek F., Middeldorp Saskia, Bryant Andrew, Schünemann Holger Parenteral anticoagulation in ambulatory patients with cancer Cochrane database of systematic reviews (Online) 2014;2014 (12):CD006652 [PubMed]
• Thijs Willemien, de Mutsert Renée, le Cessie Saskia, Hiemstra Pieter S., Rosendaal Frits R., Middeldorp Saskia, Rabe Klaus F. Reproducibility of exhaled nitric oxide measurements in overweight and obese adults BMC research notes 2014;7 (1):775 [PubMed]
• Bleker Suzanne M., Coppens Michiel, Middeldorp Saskia Sex, thrombosis and inherited thrombophilia Blood reviews 2014;28 (3):123-133 [PubMed]
• Barco Stefano, Coppens Michiel, van den Dool Erik-Jan, van de Kerkhof Daan, Stroobants An K., Middeldorp Saskia Successful co-administration of dabigatran etexilate and protease inhibitors ritonavir/lopinavir in a patient with atrial fibrillation Thrombosis and haemostasis 2014;112 (4):836-838 [PubMed]
• Kuipers S., Venemans-Jellema A., Cannegieter S. C., van Haften M., Middeldorp S., Büller H. R., Rosendaal F. R. The incidence of venous thromboembolism in commercial airline pilots: a cohort study of 2630 pilots Journal of thrombosis and haemostasis 2014;12 (8):1260-1265 [PubMed]
• Kuipers Saskia, Venemans Annemarie, Middeldorp Saskia, Büller Harry R., Cannegieter Suzanne C., Rosendaal Frits R. The risk of venous thrombosis after air travel: contribution of clinical risk factors British journal of haematology 2014;165 (3):412-413 [PubMed]
• Visser A. W., de Mutsert R., Loef M., le Cessie S., den Heijer M., Bloem J. L., Reijnierse M., Rosendaal F. R., Kloppenburg M., Middeldorp S., Rabelink A. J., Smit J. W. A., Romijn J. A., Rabe K. F., Jukema J. W., de Roos A., Hiemstra P. S., Huizinga T. W. J., Pijl H., Tamsma J. T., de Koning E. J. P., Assendelft W. J. J., Reitsma P. H., van Dijk K. Willems, de Vries A. P. J., Lamb H. J., Jazet I. M., Dekkers O. M., Biermasz N. R., Cobbaert C. M., Dekker J. M., Penninx B. W. The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2014;22 (2):197-202 [PubMed]
• Kaandorp S. P., van Mens T. E., Middeldorp S., Hutten B. A., Hof M. H. P., van der Post J. A. M., van der Veen F., Goddijn M. Time to conception and time to live birth in women with unexplained recurrent miscarriage Human reproduction (Oxford, England) 2014;29 (6):1146-1152 [PubMed]
• Di Nisio Marcello, Middeldorp Saskia Treatment of Lower Extremity Superficial Thrombophlebitis JAMA 2014;311 (7):729-730 [PubMed]
• Sanders Y. V., Giezenaar M. A., Laros-van Gorkom B. A. P., Meijer K., van der Bom J. G., Cnossen M. H., Nijziel M. R., Ypma P. F., Fijnvandraat K., Eikenboom J., Mauser-Bunschoten E. P., Leebeek F. W. G., Middeldorp S., Kors A., Zweegman S., de Meris J., Jonkers M. H., Dors N., Tamminga R. Y. J., van der Linden P. W., Gasthuis Kennemer, Eikenboom H. C. J., Smiers F. J. W., Granzen B., Hamuly K., Brons P. von Willebrand disease and aging: an evolving phenotype Journal of thrombosis and haemostasis 2014;12 (7):1066-1075 [PubMed]
• Middeldorp Saskia, Bleker Suzanne Mariëlla Women admitted to hospital during pregnancy have increased risk of venous thromboembolism that persists up to 28 days postdischarge Evidence-based nursing 2014;17 (4):103 [PubMed]

2013

• Gast Karin B., Smit Johannes W. A., den Heijer Martin, Middeldorp Saskia, Rippe Ralph C. A., le Cessie Saskia, de Koning Eelco J. P., Jukema J. W., Rabelink Ton J., de Roos Albert, Rosendaal Frits R., de Mutsert Renée, Rosendaal F. R., de Mutsert R., Rabelink T. J., Smit J. W. A., Romijn J. A., Rabe K. F., de Roos A., le Cessie S., Hiemstra P. S., Kloppenburg M., Huizinga T. W. J., Pijl H., Tamsma J. T., de Koning E. J. P., Assendelft W. J. J., Reitsma P. H., van Dijk K. Willems, de Vries A. P. J., Lamb H. J., Jazet I. M., Dekkers O. M., Biermasz N. R., Cobbaert C. M., den Heijer M., Dekker J. M., Penninx B. W. Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study Atherosclerosis 2013;229 (2):423-429 [PubMed]
• van Es Josien Adjustments in the diagnistic work-up, treatment and prognosis of pulmonary embolism 2013. 238p. ISBN 9789461917409. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Middeldorp S., Kamphuisen P. W.; Co-supervisors: Gerdes V. E. A., Douma R. A.)
• Romualdi E., Dentali F., Rancan E., Squizzato A., Steidl L., Middeldorp S., Ageno W. Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta-analysis of the literature Journal of thrombosis and haemostasis 2013;11 (2):270-281 [PubMed]
• Squizzato Alessandro, Romualdi Erica, Passamonti Francesco, Middeldorp Saskia Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia Cochrane database of systematic reviews (Online) 2013;2013 (4):CD006503 [PubMed]
• de Jong Paulien G., Goddijn Mariëtte, Middeldorp Saskia Antithrombotic therapy for pregnancy loss Human reproduction update 2013;19 (6):656-673 [PubMed]
• Lauw Mandy N., van Doormaal Frederiek F., Middeldorp Saskia, Buller Harry R. Cancer and venous thrombosis: current comprehensions and future perspectives Seminars in thrombosis and hemostasis 2013;39 (5):507-514 [PubMed]
• Lauw Mandy N., Barco Stefano, Coutinho Jonathan M., Middeldorp Saskia Cerebral venous thrombosis and thrombophilia: a systematic review and meta-analysis Seminars in thrombosis and hemostasis 2013;39 (8):913-927 [PubMed]
• van Montfoort Maurits L., Stephan Femke, Lauw Mandy N., Hutten Barbara A., van Mierlo Gerard J., Solati Shabnam, Middeldorp Saskia, Meijers Joost C. M., Zeerleder Sacha Circulating nucleosomes and neutrophil activation as risk factors for deep vein thrombosis Arteriosclerosis, thrombosis, and vascular biology 2013;33 (1):147-151 [PubMed]
• van Es Josien, Douma Renée A., Schreuder Sanne M., Middeldorp Saskia, Kamphuisen Pieter W., Gerdes Victor E. A., Beenen Ludo F. M. Clinical impact of findings supporting an alternative diagnosis on CT pulmonary angiography in patients with suspected pulmonary embolism Chest 2013;144 (6):1893-1899 [PubMed]
• Büller Harry R., Décousus Hervé, Grosso Michael A., Mercuri Michele, Middeldorp Saskia, Prins Martin H., Raskob Gary E., Schellong Sebastian M., Schwocho Lee, Segers Annelise, Shi Minggao, Verhamme Peter, Wells Phil, Agnelli Giancarlo, Angchaisuksiri Pantep, Banyai Martin, Bauersachs Rupert, van Bellen Bonno, Blüguermann Julio, Boda Zoltán, Bounameaux Henri, Brenner Benjamin, Brighton Tim, Castañon Javier Diaz, Chechulov Pavel, Chlumský Yaromir, Cohen Alexander, Davidson Bruce, Decousus Hervé, Eriksson Henry, Gallus Alexander, Gudz Ivan, Jacobson Barry, Heng Lee Lai, Lyons Roger, Meijer Karina, Minar Erich, Monreal Manuel, Nakamura Mashio, Oh Doyeun, Öngen Gül, Parakh Rajiv, Piovella Franco, Beenen Ludo, Peters Ron, Roos Yvo, Zhao J., Gerdes V. E. A., Kamphuisen P. W., Eerenberg E. S. Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism New England journal of medicine 2013;369 (15):1406-1415 [PubMed]
• van Mens T. E., Levi M. [=Marcel M.], Middeldorp S. Evolution of Factor V Leiden Thrombosis and haemostasis 2013;110 (1):23-30 [PubMed]
• Hillebrand Stefanie, Gast Karin B., de Mutsert Renée, Swenne Cees A., Jukema J. Wouter, Middeldorp Saskia, Rosendaal Frits R., Dekkers Olaf M. Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression Europace : European pacing, arrhythmias, and cardiac electrophysiology 2013;15 (5):742-749 [PubMed]
• Aarab R., van Es J., de Pont A. C. J. M., Vroom M. B., Middeldorp S. Monitoring of unfractionated heparin in critically ill patients Netherlands journal of medicine 2013;71 (9):466-471 [PubMed]
• van den Boogaard Emmy, Cohn Danny M., Korevaar Johanna C., Dawood Feroza, Vissenberg Rosa, Middeldorp Saskia, Goddijn Mariette, Farquharson Roy G. Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage Fertility and sterility 2013;99 (1):188-192 [PubMed]
• Barco Stefano, Nijkeuter Mathilde, Middeldorp Saskia Pregnancy and venous thromboembolism Seminars in thrombosis and hemostasis 2013;39 (5):549-558 [PubMed]
• van Es Josien, den Exter Paul L., Kaptein Ad A., Andela Cornelie D., Erkens Petra M. G., Klok Frederikus A., Douma Renee A., Mos Inge C. M., Cohn Danny M., Kamphuisen Pieter W., Huisman Menno V., Middeldorp Saskia Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL Thrombosis research 2013;132 (5):500-505 [PubMed]
• Bates S. M., Greer I. A., Middeldorp S., Veenstra D. L., Prabulos A.-M., Vandvik P. O. Recommendations for prophylaxis of pregnancy-related venous thromboembolism in carriers of inherited thrombophilia. Comment on the 2012 ACCP guidelines: a rebuttal Journal of thrombosis and haemostasis 2013;11 (9):1782-1784 [PubMed]
• de Mutsert Renée, den Heijer Martin, Rabelink Ton Johannes, Smit Johannes Willem Adriaan, Romijn Johannes Anthonius, Jukema Johan Wouter, de Roos Albert, Cobbaert Christa Maria, Kloppenburg Margreet, le Cessie Saskia, Middeldorp Saskia, Rosendaal Frits Richard The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection European journal of epidemiology 2013;28 (6):513-523 [PubMed]
• Goorhuis A., van Thiel P. P. A. M., Middeldorp S., van Eck B. L. F., Grobusch M. P. The tropics and the crime they did not commit Infection 2013;41 (1):275-277 [PubMed]
• Middeldorp S. Thrombosis in women: what are the knowledge gaps in 2013? Journal of thrombosis and haemostasis 2013;11 (Suppl. 1):180-191 [PubMed]
• Di Nisio Marcello, Wichers Iris M., Middeldorp Saskia Treatment for superficial thrombophlebitis of the leg Cochrane database of systematic reviews (Online) 2013;2013 (4):CD004982 [PubMed]
• Lauw Mandy N., van der Holt Bronno, Middeldorp Saskia, Meijers Joost C. M., Cornelissen Jan J., Biemond Bart J. Venous thromboembolism in adults treated for acute lymphoblastic leukaemia: Effect of fresh frozen plasma supplementation Thrombosis and haemostasis 2013;109 (4):633-642 [PubMed]

2012

• de Jong Paulien G., Coppens Michiel, Middeldorp Saskia Duration of anticoagulant therapy for venous thromboembolism: balancing benefits and harms on the long term British journal of haematology 2012;158 (4):433-441 [PubMed]
• Pijls Bart G., Valstar Edward R., Nouta Klaas-Auke, Plevier Josepha Wm, Fiocco Marta, Middeldorp Saskia, Nelissen Rob Ghh Early migration of tibial components is associated with late revision A systematic review and meta-analysis of 21,000 knee arthroplasties Acta orthopaedica 2012;83 (6):614-624 [PubMed]
• Pijls Bart G., Nieuwenhuijse Marc J., Fiocco Marta, Plevier Josepha Wm, Middeldorp Saskia, Nelissen Rob Ghh, Valstar Edward R. Early proximal migration of cups is associated with late revision in THA A systematic review and meta-analysis of 26 RSA studies and 49 survival studies Acta orthopaedica 2012;83 (6):583-591 [PubMed]
• Büller Harry R., Gallus Alex S., Pillion Gerard, Prins Martin H., Raskob Gary E., Raskob Gary, Decousus Hervé, Charbonnier Bernard, Leizorovicz Alain, Laporte Silvy, Quenet Sara, Brandjes Dees P. M., Middeldorp Saskia, Blüguermann J., Amuchastegui L., Ahuad Guerrero R., Oberti P., Alvarez C., Cassettari A., Santos D., Macin S., Santini F., Ward C., Coughlin P., Salem H., Gan E., Leyden M., Prosser I., Crispin P., Carroll P., Gallus A., McRae S., Waites J., Pilger E., Koppensteiner R., Kyrle P., Schinko H., Mrochek A., Mitkovskaya N., Prystrom A., Motte S., Ninane V., Delcroix M., Hainaut P., Schneider E., Saraiva J., Maia L., Barreto S., Fernandes Manenti E., Araujo G. Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial Lancet 2012;379 (9811):123-129 [PubMed]
• Dentali F., Ageno W., Rezoagli E., Rancan E., Squizzato A., Middeldorp S., Margaglione M., Grandone E. Low-dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta-analysis of the literature Journal of thrombosis and haemostasis 2012;10 (10):2075-2085 [PubMed]
• Reitsma Pieter H., Versteeg Henri H., Middeldorp Saskia Mechanistic View of Risk Factors for Venous Thromboembolism Arteriosclerosis, thrombosis, and vascular biology 2012;32 (3):563-568 [PubMed]
• Lussana Federico, Coppens Michiel, Cattaneo Marco, Middeldorp Saskia Pregnancy-related venous thromboembolism: Risk and the effect of thromboprophylaxis Thrombosis research 2012;129 (6):673-680 [PubMed]
• Lussana Federico, de Rooij Susanne R., Veenendaal Marjolein, Razzari Cristina, Fontana Gessica, Faioni Elena M., Painter Rebecca C., Middeldorp Saskia, Cattaneo Marco, Roseboom Tessa J. Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: A possible survival advantage? Thrombosis and haemostasis 2012;108 (2):399-401 [PubMed]
• Lauw Mandy N., Bus Erik W. N., van Wulfften Palthe Alexander F. Y., Coppens Michiel, Homburg Christa H., Middeldorp Saskia, van der Schoot C. Ellen, Koene Harry R., Biemond Bart J. Relevance of the JAK2V617F mutation in patients with deep vein thrombosis of the leg Annals of hematology 2012;91 (1):103-107 [PubMed]
• Bates Shannon M., Greer Ian A., Middeldorp Saskia, Veenstra David, Prabulos Anne-Marie, Vandvik Per Olav Response Chest 2012;142 (2):545-546 [PubMed]
• Pijls Bart G., Nieuwenhuijse Marc J., Schoones Jan W., Middeldorp Saskia, Valstar Edward R., Nelissen Rob G. H. H. RSA prediction of high failure rate for the uncoated Interax TKA confirmed by meta-analysis Acta orthopaedica 2012;83 (2):142-147 [PubMed]
• van Es J., Beenen L. F. M., Gerdes V. E. A., Middeldorp S., Douma R. A., Bossuyt P. M. M. The accuracy of D-dimer testing in suspected pulmonary embolism varies with the Wells score Journal of thrombosis and haemostasis 2012;10 (12):2630-2632 [PubMed]
• Cohn Danny M., Vansenne Fleur, de Borgie Corianne A., Middeldorp Saskia Thrombophilia testing for prevention of recurrent venous thromboembolism Cochrane database of systematic reviews (Online) 2012;2012 (12):CD007069 [PubMed]
• Di Nisio Marcello, Wichers Iris M., Middeldorp Saskia Treatment for superficial thrombophlebitis of the leg Cochrane database of systematic reviews (Online) 2012;2012 (3):CD004982 [PubMed]
• Roshani Sara Venous and arterial thrombosis : associations and risk factors 2012. 187p. [UvA Dissertations Online] Rijksuniversiteit Leiden: Faculteit Geneeskunde. (Supervisors: Middeldorp Saskia, Reitsma P. H.)
• Bates Shannon M., Greer Ian A., Middeldorp Saskia, Veenstra David L., Prabulos Anne-Marie, Vandvik Per Olav VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 2012;141 (2 Suppl):e691S-e736S [PubMed]

2011

• Pijls Bart G., Dekkers Olaf M., Middeldorp Saskia, Valstar Edward R., van der Heide Huub J. L., van der Linden-van der Zwaag Henrica M. J., Nelissen Rob G. H. H. AQUILA: assessment of quality in lower limb arthroplasty. An expert Delphi consensus for total knee and total hip arthroplasty BMC musculoskeletal disorders 2011;12 (1):173 [PubMed]
• Squizzato Alessandro, Keller Tymen, Romualdi Erica, Middeldorp Saskia Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease Cochrane database of systematic reviews (Online) 2011;2011 (1):CD005158 [PubMed]
• Middeldorp Saskia Duration of anticoagulation for venous thromboembolism BMJ (Clinical research ed.) 2011;342:d2758 [PubMed]
• Büller H. R., Destors J. M., Gallus A., Prins M. H., Raskob G., Charbonnier B., Decousus H., Leizorovicz A., Laporte S., Brandjes D. P. M. B., Middeldorp S., Pillion G., Ceresetto J. M., Hendler H., Xavier D. L., Santini F., del Carmen Gallo M., Coughlin P., Chong B., Leahy M., Ward C., Leyden M., Prosser I., Carroll P., Gan E., McRae S., Salem H., Pilger E., Koppensteiner R., Jurecka W., Forstner K., Hainaut P., Motte S., Vermassen F., Araujo G. R., Timi J. Rufino Ribas, Costa J. A., Manenti F., Yoshida W. B., Kovacs M., Delle Siega A., Rodger M., Miron M. J., Anderson D., Yeo E., Kassis J., Spacek R., Klimsa Z., Patek F., Kamphuisen P. Efficacy and safety of once weekly subcutaneous idrabiotaparinux in the treatment of patients with symptomatic deep venous thrombosis Journal of thrombosis and haemostasis 2011;9 (1):92-99 [PubMed]
• Middeldorp Saskia Evidence-based approach to thrombophilia testing Journal of thrombosis and thrombolysis 2011;31 (3):275-281 [PubMed]
• Pintao M. C., Roshani S., de Visser M. C. H., Tieken C., Tanck M. W. T., Wichers I. M., Meijers J. C. M., Rosendaal F. R., Middeldorp S., Reitsma P. H. High levels of protein C are determined by PROCR haplotype 3 Journal of thrombosis and haemostasis 2011;9 (5):969-976 [PubMed]
• Middeldorp Saskia How I treat pregnancy-related venous thromboembolism Blood 2011;118 (20):5394-5400 [PubMed]
• Roshani Sara, Cohn Danny M., Stehouwer Alexander C., Wolf Hans, van der Post Joris A. M., Büller Harry R., Kamphuisen Pieter W., Middeldorp Saskia Incidence of postpartum haemorrhage in women receiving therapeutic doses of low-molecular-weight heparin: results of a retrospective cohort study BMJ open 2011;1 (2):e000257 [PubMed]
• Middeldorp Saskia Is thrombophilia testing useful? Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2011;2011:150-155 [PubMed]
• Roeters van Lennep J. E., Meijer E., Klumper F. J. C. M., Middeldorp J. M., Bloemenkamp K. W. M., Middeldorp S. Low-molecular-weight-heparin and pregnancy, when the dose does it: a nephrologist's opinion: reply to a rebuttal Journal of thrombosis and haemostasis 2011;9 (10):2129-2130 [PubMed]
• Middeldorp Saskia Low-molecular-weight heparins have no place in recurrent miscarriage: Debate - For the motion Thrombosis research 2011;127 (Suppl. 3):S105-S109 [PubMed]
• Akl Elie A., Gunukula Sameer, Barba Maddalena, Yosuico Victor E. D., van Doormaal Frederiek F., Kuipers Saskia, Middeldorp Saskia, Dickinson Heather O., Bryant Andrew, Schünemann Holger Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation Cochrane database of systematic reviews (Online) 2011;2011 (1):CD006652 [PubMed]
• Akl Elie A., Gunukula Sameer, Barba Maddalena, Yosuico Victor E. D., van Doormaal Frederiek F., Kuipers Saskia, Middeldorp Saskia, Dickinson Heather O., Bryant Andrew, Schünemann Holger Parenteral anticoagulation in patients with cancer who have no therapeutic or prophylactic indication for anticoagulation Cochrane database of systematic reviews (Online) 2011;2011 (4):CD006652 [PubMed]
• Roeters van Lennep J. E., Meijer E., Klumper F. J. C. M., Middeldorp J. M., Bloemenkamp K. W. M., Middeldorp S. Prophylaxis with low-dose low-molecular-weight heparin during pregnancy and postpartum: is it effective? Journal of thrombosis and haemostasis 2011;9 (3):473-480 [PubMed]
• Roeters van Lennep J. E., Meijer E., Klumper F. J. C. M., Middeldorp J. M., Bloemenkamp K. W. M., Middeldorp S. Prophylaxis with low-dose low molecular weight heparin during pregnancy and the puerperium: is it effective? Reply to a rebuttal Journal of thrombosis and haemostasis 2011;9 (6):1272-1273 [PubMed]
• Tanck M. W. T., Wichers I. M., Meijers J. C. M., Büller H. R., Reitsma P. H., Middeldorp S. Quantitative trait locus for protein C in a family with thrombophilia Thrombosis and haemostasis 2011;105 (1):199-201 [PubMed]
• Roshani S., Lijfering W. M., Coppens M., Hamulyák K., Prins M. H., Büller H. R., Middeldorp S. Risk factors of arterial cardiovascular complications in patients with prior venous thromboembolism Netherlands journal of medicine 2011;69 (1):27-30 [PubMed]
• Roach Rachel E. J., Roshani Sara, Meijer Karina, Hamulyák Karly, Lijfering Willem M., Prins Martin H., Büller Harry R., Middeldorp Saskia Risk of cardiovascular disease in double heterozygous carriers and homozygous carriers of F5 R506Q (factor V Leiden) and F2 (prothrombin) G20210A: a retrospective family cohort study British journal of haematology 2011;153 (1):134-136 [PubMed]
• de Jong Paulien G., Goddijn Mariëtte, Middeldorp Saskia Testing for inherited thrombophilia in recurrent miscarriage Seminars in reproductive medicine 2011;29 (6):540-547 [PubMed]
• Douketis Jim D., Julian Jim A., Crowther Mark A., Kearon Clive, Bates Shannon M., Barone Marisa, Piovella Franco, Middeldorp Saskia, Prandoni Paolo, Johnston Marilyn, Costantini Lorrie, Ginsberg Jeffrey S. The effect of prothrombotic blood abnormalities on risk of deep vein thrombosis in users of hormone replacement therapy: a prospective case-control study Clinical and applied thrombosis/hemostasis 2011;17 (6):E106-E113 [PubMed]
• Heleen van Ommen C., Middeldorp Saskia Thrombophilia in childhood: to test or not to test Seminars in thrombosis and hemostasis 2011;37 (7):794-801 [PubMed]
• van Vlijmen Elizabeth F. W., Veeger Nic J. G. M., Middeldorp Saskia, Hamulyák Karly, Prins Martin H., Büller Harry R., Meijer Karina Thrombotic risk during oral contraceptive use and pregnancy in women with factor V Leiden or prothrombin mutation: a rational approach to contraception Blood 2011;118 (8):2055-61; quiz 2375 [PubMed]
• Kaandorp S. P. Unexplained recurrent miscarriage 2011. 127p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: van der Veen F., Middeldorp S.; Co-supervisors: Goddijn M., van der Post J. A. M.)

2010

• Kaandorp Stef P., Goddijn Mariette, Middeldorp Saskia Antithrombotic Medications and Recurrent Miscarriage REPLY New England journal of medicine 2010;363 (9):888
• Kaandorp Stef P., Goddijn Mariëtte, Van Der Post Joris A.M., Hutten Barbara A., Verhoeve Harold R., Hamulyák Karly, Willem Mol Ben, Folkeringa Nienke, Nahuis Marleen, Papatsonis Dimitri N.M., Büller Harry R., Van Der Veen Fulco, Middeldorp Saskia Aspirin plus heparin or aspirin alone in women with recurrent miscarriage Obstetrical & gynecological survey 2010;65 (10):621-622
• Kaandorp Stef P., Goddijn Mariëtte, van der Post Joris A. M., Hutten Barbara A., Verhoeve Harold R., Hamulyák Karly, Mol Ben Willem, Folkeringa Nienke, Nahuis Marleen, Papatsonis Dimitri N. M., Büller Harry R., van der Veen Fulco, Middeldorp Saskia Aspirin plus heparin or aspirin alone in women with recurrent miscarriage New England journal of medicine 2010;362 (17):1586-1596 [PubMed]
• Yusuf Erlangga, Nelissen Rob G., Ioan-Facsinay Andreea, Stojanovic-Susulic Vedrana, Degroot Jeroen, van Osch Gerjo, Middeldorp Saskia, Huizinga Tom W. J., Kloppenburg Margreet Association between weight or body mass index and hand osteoarthritis: a systematic review Annals of the rheumatic diseases 2010;69 (4):761-765 [PubMed]
• Mulder René, van Schouwenburg Inge M., Mahmoodi Bakhtawar K., Veeger Nic J. G. M., Mulder André B., Middeldorp Saskia, Kluin-Nelemans Hanneke C., Lijfering Willem M. Associations between high factor VIII and low free protein S levels with traditional arterial thrombotic risk factors and their risk on arterial thrombosis: results from a retrospective family cohort study Thrombosis research 2010;126 (4):e249-e254 [PubMed]
• Mäkelburg Anja B. U., Veeger Nic J. G. M., Middeldorp Saskia, Hamulyák Karly, Prins Martin H., Büller Harry R., Lijfering Willem M. Different risk of deep vein thrombosis and pulmonary embolism in carriers with factor V Leiden compared with non-carriers, but not in other thrombophilic defects. Results from a large retrospective family cohort study Haematologica 2010;95 (6):1030-1033 [PubMed]
• Schreijer A. J. M., Hoylaerts M. F., Meijers J. C. M., Lijnen H. R., Middeldorp S., Büller H. R., Reitsma P. H., Rosendaal F. R., Cannegieter S. C. Explanations for coagulation activation after air travel Journal of thrombosis and haemostasis 2010;8 (5):971-978 [PubMed]
• Decousus Hervé, Prandoni Paolo, Mismetti Patrick, Bauersachs Rupert M., Boda Zoltán, Brenner Benjamin, Laporte Silvy, Matyas Lajos, Middeldorp Saskia, Sokurenko German, Leizorovicz Alain, Décousus H., Leizorovicz A., Bauersachs R., Brenner B., Laporte S., Mismetti P., Prandoni P., Richard-Lordereau I., Boda Z., Matyas L., Sokurenko G., Schulman S., Cucherat M., Ford I., Monreal M., Becker F., Bost V., Girard P., Constans J., Gauthier E., Seymour L., Froloshki B., Stober P., Borthwick L., Jaques D., Trelfa A., Allende-Echevarrietta P., Kensit S., Kovacs I., Laursen E., Dramov A., Chlumsky J., Maasalu K., Quere I., Kiskinis D., Hoffman R., Piovella F., Kamphuisen P., Gerdes V. Fondaparinux for the treatment of superficial-vein thrombosis in the legs New England journal of medicine 2010;363 (13):1222-1232 [PubMed]
• Cohn D. M., Repping S., Büller H. R., Meijers J. C. M., Middeldorp S. Increased sperm count may account for high population frequency of factor V Leiden Journal of thrombosis and haemostasis 2010;8 (3):513-516 [PubMed]
• Thijs W., Rabe K. F., Rosendaal F. R., Middeldorp S. Predominance of left-sided deep vein thrombosis and body weight Journal of thrombosis and haemostasis 2010;8 (9):2083-2084 [PubMed]
• Kaandorp S. P., Lauw M. N., van der Schoot C. E., Goddijn M., van der Veen F., Koene H. R., Biemond B. J., Middeldorp S. Prevalence of JAK2V617F mutation in women with unexplained recurrent miscarriage Journal of thrombosis and haemostasis 2010;8 (12):2837-2839 [PubMed]
• Klok F. A., Cohn D. M., Middeldorp S., Scharloo M., Büller H. R., van Kralingen K. W., Kaptein A. A., Huisman M. V. Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire Journal of thrombosis and haemostasis 2010;8 (3):523-532 [PubMed]
• Cohn D. M., Goddijn M., Middeldorp S., Korevaar J. C., Dawood F., Farquharson R. G. Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy Journal of thrombosis and haemostasis 2010;8 (10):2208-2213 [PubMed]
• Lijfering Willem M., Middeldorp Saskia, Veeger Nic J. G. M., Hamulyák Karly, Prins Martin H., Büller Harry R., van der Meer Jan Risk of Recurrent Venous Thrombosis in Homozygous Carriers and Double Heterozygous Carriers of Factor V Leiden and Prothrombin G20210A Circulation 2010;121 (15):1706-1712 [PubMed]
• Cohn Danny M. Thrombophilia ad dies vitae 2010. 184p. ISBN 9789090250052. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Büller H. R.; Co-supervisors: Middeldorp S., Kamphuisen P. W.)
• Wichers Iris M. Unsolved issues in etiology and treatment of venous thrombosis 2010. 188p. ISBN 9789490122980. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Büller Harry R.; Co-supervisors: Middeldorp S., Tanck M. W. T.)

2009

• Kuipers Saskia Air travel and venous thrombosisLeiden: 2009. 117p. ISBN 9789490122492. [UvA Dissertations Online] Rijksuniversiteit Leiden: Faculteit Geneeskunde. (Supervisors: Rosendaal Frits R., Büller Harry R.; Co-supervisors: Middeldorp Saskia, Cannegieter Suzanne C.)
• Lijfering Willem M., Veeger Nic J. G. M., Middeldorp Saskia, Hamulyák Karly, Prins Martin H., Büller Harry R., van der Meer Jan A lower risk of recurrent venous thrombosis in women compared with men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families Blood 2009;114 (10):2031-2036 [PubMed]
• Kaandorp Stef, Di Nisio Marcello, Goddijn Mariette, Middeldorp Saskia Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome Cochrane database of systematic reviews (Online) 2009;2009 (1):CD004734 [PubMed]
• Wichers Iris M., Tanck Michael W. T., Meijers Joost C. M., Lisman Ton, Reitsma Pieter H., Rosendaal Frits R., Büller Harry R., Middeldorp Saskia Assessment of coagulation and fibrinolysis in families with unexplained thrombophilia Thrombosis and haemostasis 2009;101 (3):465-470 [PubMed]
• Middeldorp Saskia Epidemiology of hormone-related venous thromboembolism Thrombosis research 2009;123 (Suppl. 2):S65-S69 [PubMed]
• Abdelmalik N., Ruhé H. G., Barwari K., van den Dool E. J., Meijers J. C. M., Middeldorp S., Büller H. R., Schene A. H., Kamphuisen P. W. Het effect van de selectieve serotonineheropnameremmer paroxetine op de bloedplaatjesfunctie wordt beïnvloed door een SLC6A4-serotoninetransporterpolymorfisme Nederlands tijdschrift voor hematologie 2009;6 (6):211-219
• Knol H. M., Veeger N. J. G. M., Middeldorp S., Hamulyák K., van der Meer J. High thrombin-activatable fibrinolysis inhibitor levels may protect against recurrent fetal loss Journal of thrombosis and haemostasis 2009;7 (5):903-906 [PubMed]
• Mäkelburg Anja B. U., Lijfering Willem M., Middeldorp Saskia, Hamulyák Karly, Veeger Nic J. G. M., Prins Martin H., Büller Harry R., van der Meer Jan Low absolute risk of venous and arterial thrombosis in hyperhomocysteinaemia - A prospective family cohort study in asymptomatic subjects Thrombosis and haemostasis 2009;101 (1):209-212 [PubMed]
• Minnee Robert C., Middeldorp Saskia, Legemate Dink A. Malformatie van de V. cava inferior, een risicofactor voor diepveneuze trombose Nederlands tijdschrift voor geneeskunde 2009;153 (11):496-500 [PubMed]
• Wichers I. M., Garcia A. A., Tanck M. W. T., Middeldorp S., Reitsma P. H. No linkage for venous thrombosis at a candidate region on chromosome 18 in Dutch thrombophilic families Journal of thrombosis and haemostasis 2009;7 (7):1239-1240 [PubMed]
• Cohn D. M., Nelis E. A., Busweiler L. A., Kaptein A. A., Middeldorp S. Quality of life after pulmonary embolism: the development of the PEmb-QoL questionnaire Journal of thrombosis and haemostasis 2009;7 (6):1044-1046 [PubMed]
• Krekel N. M. A., Coppens M., Büller H. R., Middeldorp S. Reliability of questionnaires on the use of thromboprophylaxis Journal of thrombosis and haemostasis 2009;7 (6):1042-1043 [PubMed]
• Lijfering Willem M., Brouwer Jan-Leendert P., Veeger Nic J. G. M., Bank Ivan, Coppens Michiel, Middeldorp Saskia, Hamulyak Karly, Prins Martin H., Buller Harry R., van der Meer Jan Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives Blood 2009;113 (21):5314-5322 [PubMed]
• Folkeringa Nienke, Korteweg Fleurisca J., Veeger Nic J. G. M., Middeldorp Saskia, Hamulyak Karly, Prins Martin H., Erwich Jan Jaap H. M., Büller Harry R., van der Meer Jan Thrombin activatable fibrinolysis inhibitor (TAFI) is not associated with fetal loss, a retrospective study Thrombosis research 2009;123 (3):511-514 [PubMed]
• Cohn Danny, Vansenne Fleur, de Borgie Corianne, Middeldorp Saskia Thrombophilia testing for prevention of recurrent venous thromboembolism Cochrane database of systematic reviews (Online) 2009;2009 (1):CD007069 [PubMed]

2008

• Folkeringa Nienke, Coppens Michiel, Veeger Nic J. G. M., Bom Victor J. J., Middeldorp Saskia, Hamulyak Karly, Prins Martin H., Büller Harry R., van der Meer Jan Absolute risk of venous and arterial thromboembolism in thrombophilic families is not increased by high thrombin-activatable fibrinolysis inhibitor (TAFI) levels Thrombosis and haemostasis 2008;100 (1):38-44 [PubMed]
• Squizzato A., Romualdi E., Middeldorp S. Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia Cochrane database of systematic reviews (Online) 2008;2008 (2):CD006503 [PubMed]
• Wichers I. M., Haighton M., Büller H. R., Middeldorp S. A retrospective analysis of patients treated for superficial vein thrombosis Netherlands journal of medicine 2008;66 (10):423-427 [PubMed]
• van Doormaal F. F., Büller H. R., Middeldorp S. Development in anticoagulant therapy Critical reviews in oncology/hematology 2008;66 (2):145-154 [PubMed]
• Middeldorp Saskia, van Hylckama Vlieg Astrid Does thrombophilia testing help in the clinical management of patients? British journal of haematology 2008;143 (3):321-335 [PubMed]
• Abdelmalik N., Ruhé H. G., Barwari K., van den Dool E.-J., Meijers J. C. M., Middeldorp S., Büller H. R., Schene A. H., Kamphuisen P. W. Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism Journal of thrombosis and haemostasis 2008;6 (12):2168-2174 [PubMed]
• Buller H., Deitchman D., Prins M. [=Martin H.], Segers A., Brenner B., Brighton T., Chlumsky J., Davidson B., Decousus H., Eriksson H., Jacobson B., van der Meer J., Minar E., Piovella F., Tomkowski W., Baarslag H., Brandjes D., Bergqvist D., Laporte S., Mismetti P., Baker R., Blombery P., Chong B., Gallus A., Gan E., Salem H., Hirschl M., Pilger E., Kovarova K., Malý J., Matoska P., Patek F., Spacek R., Vitovec M., Zak J., Emmerich J., Lacroix P., Mottier D., Quere I., Roy P., Schmidt J., Elias M., Gavish D., Hoffman R., Hussein O., Lishner M., Lugassy G., Schliamser L., Shpilberg O., Middeldorp S. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study Journal of thrombosis and haemostasis 2008;6 (8):1313-1318 [PubMed]
• Middeldorp S. Heparin: from animal organ extract to designer drug Thrombosis research 2008;122 (6):753-762 [PubMed]
• Lijfering Willem M., Coppens Michiel, Veeger Nic J. G. M., Middeldorp Saskia, Hamulyák Karly, Prins Martin H., Büller Harry R., van der Meer Jan Hyperhomocysteinemia is not a risk factor for venous and arterial thrombosis, and is associated with elevated factor VIII levels Thrombosis research 2008;123 (2):244-250 [PubMed]
• Rodger Marc A., Paidas Michael, McLintock Claire, Claire McLintock, Middeldorp Saskia, Kahn Susan, Martinelli Ida, Hague William, Rosene Montella Karen, Greer Ian Inherited thrombophilia and pregnancy complications revisited Obstetrics and gynecology 2008;112 (2 Part 1):320-324 [PubMed]
• Homsma Sietske J. M., Huijgen Roeland, Middeldorp Saskia, Sijbrands Eric J. G., Kastelein John J. P. Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance European journal of human genetics 2008;16 (1):14-17 [PubMed]
• Homsma Sietske J. M., Huijgen Roeland, Middeldorp Saskia, Sijbrands Eric J. G., Kastelein John J. P. Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance [Corrigendum] European journal of human genetics 2008;16 (2):275 [PubMed]
• Akl Elie A., van Doormaal Frederiek F., Barba Maddalena, Kamath Ganesh, Kim Seo Young, Kuipers Saskia, Middeldorp Saskia, Yosuico Victor, Dickinson Heather O., Schünemann Holger J. Parenteral anticoagulation may prolong the survival of patients with limited small cell lung cancer: a Cochrane systematic review Journal of experimental & clinical cancer research 2008;27:4 [PubMed]
• Coppens M., Reijnders J. H., Middeldorp S., Doggen C. J. M., Rosendaal F. R. Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis Journal of thrombosis and haemostasis 2008;6 (9):1474-1477 [PubMed]
• Cohn D. M., Vansenne F., Kaptein A. A., de Borgie C. A. J. M., Middeldorp S. The psychological impact of testing for thrombophilia: a systematic review Journal of thrombosis and haemostasis 2008;6 (7):1099-1104 [PubMed]
• Coppens Michiel Thrombophilia 2008. 135p. ISBN 9789090227450. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Buller Harry R.; Co-supervisor: Middeldorp S.)
• Cohn Danny M., Vansenne F., De Borgie C., Middeldorp S. Thrombophilia testing for prevention of recurrent venous thromboembolism Cochrane database of systematic reviews (Online) 2008 (2)
• Cohn D. M., Middeldorp S. Vroegtijdige beëindiging van het onderzoek naar het nut van trombofilietests bij een eerste veneuze trombo-embolie: het NOSTRADAMUS-onderzoek Nederlands tijdschrift voor geneeskunde 2008;152 (38):2093-2094 [PubMed]

2007

• Bank Ivan, van de Poel Marlène H. W., Coppens Michiel, Hamulyák Karly, Prins Martin H., van der Meer Jan, Veeger Nic J. G. M., Büller Harry R., Middeldorp Saskia Absolute annual incidences of first events of venous thromboembolism and arterial vascular events in individuals with elevated FVIII:c. A prospective family cohort study Thrombosis and haemostasis 2007;98 (5):1040-1044 [PubMed]
• Keller T. T., Squizzato A., Middeldorp S. Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease Cochrane database of systematic reviews (Online) 2007;2007 (3):CD005158 [PubMed]
• Coppens M., van Mourik J. A., Eckmann C. M., Buller H. R., Middeldorp S. Current practise of testing for inherited thrombophilia Journal of thrombosis and haemostasis 2007;5 (9):1979-1981 [PubMed]
• Cohn D. M., Middeldorp S. Een multicentrisch gerandomiseerd klinisch onderzoek naar het nut van trombofilietests bij een eerste veneuze trombo-embolie: het NOSTRADAMUS-onderzoek Nederlands tijdschrift voor geneeskunde 2007;151 (6):371-373 [PubMed]
• Cohn D. M., Middeldorp S. Necessity of screening for thrombophilia at diagnosis of venous thromboembolism: outline of the NOSTADAMUS intervention trial. Journal of thrombosis and haemostasis 2007;5 (Suppl. 2):P-M-470
• Coppens M., Folkeringa N., Teune M. J., Hamulyak K., van der Meer J., Prins M. H., Buller H. R., Middeldorp S. Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutation: reply to a rebuttal Journal of thrombosis and haemostasis 2007;5 (9):1992-1994 [PubMed]
• Coppens M., Folkeringa N., Teune M. J., Hamulyak K., van der Meer J., Prins M. H., Buller H. R., Middeldorp S. Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations Journal of thrombosis and haemostasis 2007;5 (7):1444-1448 [PubMed]
• Akl E. A., van Doormaal F. F., Barba M., Kamath G., Kim S. Y., Kuipers S., Middeldorp S., Yosuico V., Dickinson H. O., Schünemann H. J. Parenteral anticoagulation for prolonging survival in patients with cancer who have no other indication for anticoagulation Cochrane database of systematic reviews (Online) 2007;2007 (3):CD006652 [PubMed]
• Middeldorp Saskia Pregnancy failure and heritable thrombophilia Seminars in hematology 2007;44 (2):93-97 [PubMed]
• Kuipers Saskia, Cannegieter Suzanne C., Middeldorp Saskia, Robyn Luc, Buller Harry R., Rosendaal Frits R. The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations PLoS medicine 2007;4 (9):e290-1514 [PubMed]
• Lijfering Willem M., Coppens Michiel, van de Poel Marlene H. W., Middeldorp Saskia, Hamulyak Karly, Bank Ivan, Veeger Nic J. G. M., Prins Martin H., Bueller Harry R., van der Meer Jan The risk of venous and arterial thrombosis in hyperhomocysteinaemia is low and mainly depends on concomitant thrombophilic defects Thrombosis and haemostasis 2007;98 (2):457-463 [PubMed]
• Middeldorp S. Thrombophilia and pregnancy complications: cause or association? Journal of thrombosis and haemostasis 2007;5 (Suppl. 1):276-282 [PubMed]
• Cohn Danny M., Roshani Sara, Middeldorp Saskia Thrombophilia and venous thromboembolism: implications for testing Seminars in thrombosis and hemostasis 2007;33 (6):573-581 [PubMed]
• Middeldorp Saskia, Levi Marcel Thrombophilia: an update Seminars in thrombosis and hemostasis 2007;33 (6):563-572 [PubMed]
• Di Nisio Marcello Thrombosis and cancer: advances in diagnosis and prognosis 2007. 212p. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Richel Dick J., Buller Harry R.; Co-supervisor: Middeldorp S.)
• Kuipers S., Schreijer A. J. M., Cannegieter S. C., Bueller H. R., Rosendaal F. R., Middeldorp S. Travel and venous thrombosis: a systematic review Journal of internal medicine 2007;262 (6):615-634 [PubMed]
• Di Nisio M., Middeldorp S., Wichers I. M. Treatment for superficial thrombophlebitis of the leg Cochrane database of systematic reviews (Online) 2007;2007 (1):CD004982 [PubMed]
• Di Nisio M., Wichers I. M., Middeldorp S. Treatment for superficial thrombophlebitis of the leg Cochrane database of systematic reviews (Online) 2007;2007 (2):CD004982 [PubMed]
• Cohn D. M., Middeldorp S. Trombofiliescreening bij VTE: het NOSTRADAMUS onderzoek Nederlands tijdschrift voor hematologie 2007;4:144-145
• Hamerlynck J. V. Th H., Middeldorp S., Hooft L. Uit de Cochrane Library: fosfodiësteraseremmers effectief bij diabetici met erectiestoornissen Nederlands tijdschrift voor geneeskunde 2007;151 (38):2101-2104 [PubMed]
• Cohn D. M., Middeldorp S. Wanneer is bij het optreden van long-embolieën trombofilie-onderzoek zinnig?in: J. Asin, R.J.H. Koppers, G.P.M. Ten Velde, editors. Longartsen Vademecum. Houten: A.J.J.M. van Meyel; 2007. p. 1-5

2006

• Schreijer A. J. M., Cannegieter S. C., Meijers J. C. M., Middeldorp S., Büller H. R., Rosendaal F. R. Activation of coagulation system during air travel: a crossover study Lancet 2006;367 (9513):832-838 [PubMed]
• Coppens Michiel, van de Poel Marlene H., Bank Ivan, Hamulyak Karly, van der Meer Jan, Veeger Nic J., Prins Martin H., Buller Harry R., Middeldorp Saskia A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation Blood 2006;108 (8):2604-2607 [PubMed]
• Middeldorp S., Goddijn M. Herhaalde miskramen en het mogelijke nut van antistollingsbehandeling Tijdschrift voor verloskundigen 2006;85:29-33
• Middeldorp S., Goddijn M. Herhaalde miskramen en trombofilie Nederlands tijdschrift voor geneeskunde 2006;150 (4):189-193 [PubMed]
• Middeldorp S. Het ALIFE-onderzoek: herhaalde miskramen en het mogelijke nut van antistollingsbehandeling bij vrouwen met en zonder erfelijke trombofilie Nederlands tijdschrift voor hematologie 2006;3 (1):39-40
• Coppens Michiel, Kaandorp Stef P., Middeldorp Saskia Inherited thrombophilias Obstetrics and gynecology clinics of North America 2006;33 (3):357-374 [PubMed]
• Hamerlynck J. V. Th H., Middeldorp S., Scholten R. J. P. M. Uit de Cochrane Library: door dragen van elastische kousen tijdens langeafstandsvluchten minder kans op asymptomatische diepe veneuze trombose Nederlands tijdschrift voor geneeskunde 2006;150 (45):2486-2488 [PubMed]
• Hamerlynck J. V. Th H., Middeldorp S., Scholten R. J. P. M. Uit de Cochrane Library: door zonlicht beschadigde huid te verbeteren met retinoïdecrèmes en niet met andere lokale behandelingen Nederlands tijdschrift voor geneeskunde 2006;150 (3):140-142 [PubMed]
• Hamerlynck J. V. T. H., Middeldorp S., Scholten R. J. P. M. Uit de Cochrane Library: effectieve maatregelen beschikbaar voor valpreventie bij ouderen Nederlands tijdschrift voor geneeskunde 2006;150 (7):374-376 [PubMed]
• Hamerlynck J. V. Th H., Middeldorp S., Scholten R. J. P. M. Uit de Cochrane Library: met postmenopauzale hormonale substitutietherapie geen bescherming tegen hart-vaatziekte, wel meer kans op veneuze trombo-embolie Nederlands tijdschrift voor geneeskunde 2006;150 (10):546-548 [PubMed]
• Kuipers S., Cannegieter S. C., Middeldorp S., Rosendaal F. R., Büller H. R. Use of preventive measures for air travel-related venous thrombosis in professionals who attend medical conferences Journal of thrombosis and haemostasis 2006;4 (11):2373-2376 [PubMed]

2005

• Di Nisio M., Peters L. W., Middeldorp S. Anticoagulants for the treatment of recurrent pregnancy loss in women without antiphospholipid syndrome Cochrane database of systematic reviews (Online) 2005;2005 (2):CD004734 [PubMed]
• Deguchi H., Bouma B. N., Middeldorp S., Lee Y. M., Griffin J. H. Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide Journal of thrombosis and haemostasis 2005;3 (5):935-938 [PubMed]
• Di Nisio Marcello, Middeldorp Saskia, Büller Harry R. Direct thrombin inhibitors New England journal of medicine 2005;353 (10):1028-1040 [PubMed]
• Douketis J. D., Julian J. A., Kearon C., Anderson D. R., Crowther M. A., Bates S. M., Barone M., Piovella F., Turpie A. G., Middeldorp S., van Nguyen P., Prandoni P., Wells P. S., Kovacs M. J., Macgillavry M. R., Costantini L., Ginsberg J. S. Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study Journal of thrombosis and haemostasis 2005;3 (5):943-948 [PubMed]
• Bank I., Libourel E. J., Middeldorp S., Hamulyák K., van Pampus E. C. M., Koopman M. M. W., Prins M. H., van der Meer J., Büller H. R. Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis Journal of thrombosis and haemostasis 2005;3 (1):79-84 [PubMed]
• Middeldorp S. Hormone replacement therapy and arterial thrombotic disease Thrombosis research 2005;115 (Suppl. 1):68-71 [PubMed]
• Middeldorp S. Low-molecular-weight heparin to prevent pregnancy loss in thrombophilic women: need for placebo-controlled studies Journal of thrombosis and haemostasis 2005;3 (4):788-789
• Middeldorp Saskia Oral contraceptives and the risk of venous thromboembolism Gender medicine 2005;2 (Suppl. A):S3-S9 [PubMed]
• Libourel Eduard J., Bank Ivan, Veeger Nic J. G. M., Hamulyàk Karly, Middeldorp Saskia, Prins Martin H., Büller Harry R., van der Meer Jan Protein S type III deficiency is no risk factor for venous and arterial thromboembolism in 168 thrombophilic families: a retrospective study Blood coagulation & fibrinolysis 2005;16 (2):135-140 [PubMed]
• Verdonkschot A. E. M., Vasmel W. L. E., Middeldorp S., van der Schoot J. T. M. Skin reactions due to low molecular weight heparin in pregnancy: a strategic dilemma Archives of gynecology and obstetrics 2005;271 (2):163-165 [PubMed]
• Wichers Iris M., Di Nisio Marcello, Büller Harry R., Middeldorp Saskia Treatment of superficial vein thrombosis to prevent deep vein thrombosis and pulmonary embolism: a systematic review Haematologica 2005;90 (5):672-677 [PubMed]
• Buller H. R., Sohne M., Middeldorp S. Treatment of venous thromboembolism Journal of thrombosis and haemostasis 2005;3 (8):1554-1560 [PubMed]
• Hamerlynck J. V. T., Middeldorp S., Scholten R. J. P. M. Uit de Cochrane Library: elektrisch tandenpoetsen met oscillerende roterende beweging beter tegen tandplaque en gingivitis dan poetsen met een conventionele tandenborstel Nederlands tijdschrift voor geneeskunde 2005;149 (48):2673-2675 [PubMed]
• Hamerlynck J. V. T. H. H., Middeldorp S., Scholten R. J. P. M. Uit de Cochrane Library: introductie Nederlands tijdschrift voor geneeskunde 2005;149 (41):2278
• Hamerlynck J. V. Th H., Middeldorp S. Uit de Cochrane Library: routinematig gebruik van een maagsonde na een abdominale operatie niet zinvol Nederlands tijdschrift voor geneeskunde 2005;149 (41):2279-2280 [PubMed]
• Hamerlynck J. V. Th H., Middeldorp S. Uit de Cochrane Library: routinematig losmaken van de vliezen ('strippen') ter inleiding van de baring bij aterme zwangeren wel effectief, maar niet altijd zinvol Nederlands tijdschrift voor geneeskunde 2005;149 (45):2508-2510 [PubMed]

2004

• Middeldorp S. ALIFE: onderzoek naar het nut van stollingsremmers tegen miskramen Nieuwsbrief vasculaire geneeskunde 2004;1 (3):21-ev.
• Middeldorp S., Peters M. Diagnose in beeld (177). Een levenloze zuigeling Nederlands tijdschrift voor geneeskunde 2004;148 (23):1168; author reply 1168 [PubMed]
• Middeldorp S., Peters M. [Diagnostic image (177). A lifeless infant. Shaken baby syndrome] Nederlands tijdschrift voor geneeskunde 2004;148 (23):1168--
• Libourel Eduard J., Baljé-Volkers Degrees Corine P., Hamulyàk Karly, Prins Martin H., Middeldorp Saskia, Büller Harry R., van der Meer Jan High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study Haematologica 2004;89 (1):118-120 [PubMed]
• Middeldorp S. Low-molecular-weight heparin to prevent pre-eclampsia: there is no evidence and potential harm Netherlands journal of medicine 2004;62 (3):69-70 [PubMed]
• Bank Ivan, Libourel Eduard J., Middeldorp Saskia, van Pampus Elisabeth C. M., Koopman Maria M. W., Hamulyák Karly, Prins Martin H., van der Meer Jan, Büller Harry R. Prothrombin 20210A mutation - A mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study Archives of internal medicine 2004;164 (17):1932-1937 [PubMed]
• Bank Ivan, Scavenius Michael P. R. B., Büller Harry R., Middeldorp Saskia Social aspects of genetic testing for factor V leiden mutation in healthy individuals and their importance for daily practice Thrombosis research 2004;113 (1):7-12 [PubMed]
• Weitz Jeffrey I., Middeldorp Saskia, Geerts William, Heit John A. Thrombophilia and new anticoagulant drugs Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2004;2004:424-438 [PubMed]
• Locadia Mirjam, Bossuyt Patrick M. M., Stalmeier Peep F. M., Sprangers Mirjam A. G., van Dongen Carlo J. J., Middeldorp Saskia, Bank Ivan, van der Meer Jan, Hamulyák Karly, Prins Martin H. Treatment of venous thromboembolism with vitamin K antagonists: patients' health state valuations and treatment preferences Thrombosis and haemostasis 2004;92 (6):1336-1341 [PubMed]
• Middeldorp Saskia, van de Poel Marlène H., Bank Ivan, Hamulyák Karly, Libourel Eduard J., Koopman Maria M. W., Prins Martin H., van der Meer Jan, Büller Harry R. Unselected women with elevated levels of factor VIII:C or homocysteine are not at increased risk for obstetric complications Thrombosis and haemostasis 2004;92 (4):787-790 [PubMed]
• Middeldorp S., van der Meer J. Veneuze trombo-emboliein: H. R. Büller, J. J. P. Kastelein, E. S. G. Stroes, editors. Vasculaire geneeskunde. Alphen a/d Rijn: Van Zuiden; 2004. p. 223-235
• Wichers I. M., Middeldorp S. Zin van screenen op trombofilie bij patiënten met een eerste veneuze trombo-embolie Nederlands tijdschrift voor hematologie 2004;1 (2):42-47

2003

• Bank Ivan, Tick Lidwien W., Hutten Barbara A., Kramer Mark H. H., Middeldorp Saskia, Büller Harry R. Acquired and inherited thrombophilic factors and the risk for residual venous thrombosis Pathophysiology of haemostasis and thrombosis 2003;33 (4):192-196 [PubMed]
• Bank I. Aetiology and treatment of venous thromboembolism 2003. 196p. ISBN 9789009017110. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Büller H. R.; Co-supervisor: Middeldorp S.)
• Middeldorp S. Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - No Journal of thrombosis and haemostasis 2003;1 (10):2073-2074 [PubMed]
• Bank I., Libourel E. J., Middeldorp S., van der Meer J., Büller H. R. High rate of skin complications due to low-molecular-weight heparins in pregnant women Journal of thrombosis and haemostasis 2003;1 (4):859-861 [PubMed]
• Middeldorp S., Büller H. R., Prins M. H. Risk for venous thromboembolism in carriers of the factor V Leiden mutation - In response Annals of internal medicine 2003;138 (1):76-77

2002

• Middeldorp Saskia, van der Meer Jan, Hamulyák Karly, Büller Harry R. A rebuttal: Counseling pregnant women with factor V Leiden homozygosity: Use absolute instead of relative risks Thrombosis and haemostasis 2002;87 (2):360-361 [PubMed]
• Libourel Eduard J., Bank Ivan, Meinardi Johan R., Baljé -Volkers Corinne P., Hamulyak Karly, Middeldorp Saskia, Koopman Maria M. W., van Pampus Elisabeth C. M., Prins Martin H., Büller Harry R., van der Meer Jan Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism Haematologica 2002;87 (10):1068-1073 [PubMed]
• Middeldorp S., Büller H. R., Vandenbroucke J. P., Helmerhorst F. M., Rosendaal F. R. Nadelige cardiovasculaire effecten van postmenopauzale hormonale suppletie Nederlands tijdschrift voor geneeskunde 2002;146 (45):2123-2127 [PubMed]
• Meinardi Johan R., Middeldorp Saskia, de Kam Pieter J., Koopman Maria M. W., van Pampus Elisabeth C. M., Hamulyák Karly, Prins Martin H., Büller Harry R., van der Meer Jan The incidence of recurrent venous thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders British journal of haematology 2002;116 (3):625-631 [PubMed]
• Middeldorp S., van der Meer J. Veneuze trombo-emboliein: H. R. Büller, J. J. P. Kastelein, E. S. G. Stroes, editors. Vasculaire geneeskunde. S.l.: Van Zuiden Communications; 2002. p. 197-208

2001

• Middeldorp S., Meinardi J. R., Koopman M. M., van Pampus E. C., Hamulyák K., van der Meer J., Prins M. H., Büller H. R. A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism Annals of internal medicine 2001;135 (5):322-327 [PubMed]
• Middeldorp S., Rosing J., Bouma B. N., Büller H. R. Effecten van orale anticonceptiva van de tweede en de derde generatie op de hemostase Nederlands tijdschrift voor geneeskunde 2001;145 (6):252-256 [PubMed]
• Middeldorp S., Prins M. H., Büller H. R. Geen indicatie voor trombofilieonderzoek bij patiënten met idiopathische veneuze trombo-embolie en hun familieleden Nederlands tijdschrift voor geneeskunde 2001;145 (22):1047-1051 [PubMed]
• Vandenbroucke J. P., Rosing J., Bloemenkamp K. W., Middeldorp S., Helmerhorst F. M., Bouma B. N., Rosendaal F. R. Oral contraceptives and the risk of venous thrombosis New England journal of medicine 2001;344 (20):1527-1535 [PubMed]
• Meinardi J. R., Middeldorp S., de Kam P. J., Koopman M. M., van Pampus E. C., Hamulyák K., Prins M. H., Büller H. R., van der Meer J. Risk of venous thromboembolism in carriers of factor V Leiden with a concomitant inherited thrombophilic defect: a retrospective analysis Blood coagulation & fibrinolysis 2001;12 (8):713-720 [PubMed]
• Middeldorp S., Libourel E. J., Hamulyák K., van der Meer J., Büller H. R. The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden British journal of haematology 2001;113 (2):553-555 [PubMed]

2000

• Tans G., Curvers J., Middeldorp S., Thomassen M. C., Meijers J. C., Prins M. H., Bouma B. N., Büller H. R., Rosing J. A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways Thrombosis and haemostasis 2000;84 (1):15-21 [PubMed]
• Middeldorp S., Meijers J. C., van den Ende A. E., van Enk A., Bouma B. N., Tans G., Rosing J., Prins M. H., Büller H. R. Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study Thrombosis and haemostasis 2000;84 (1):4-8 [PubMed]
• Franco R. F., Middeldorp S., Meinardi J. R., van Pampus E. C., Reitsma P. H. Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers British journal of haematology 2000;111 (1):118-121 [PubMed]
• Bank I., Middeldorp S., Büller H. R. Hereditary and acquired thrombophilia Seminars in respiratory and critical care medicine 2000;21 (6):483-491 [PubMed]
• Middeldorp S., Büller H. R. How to decide on the optimal duration of anticoagulatn therapy in carriers of the factor V Leiden mutation Thrombosis and haemostasis 2000;84 (5):740-741 [PubMed]
• Meijers J. C., Middeldorp S., Tekelenburg W., van den Ende A. E., Tans G., Prins M. H., Rosing J., Büller H. R., Bouma B. N. Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives Thrombosis and haemostasis 2000;84 (1):9-14 [PubMed]
• Bijsterveld N. R., Middeldorp S., Berends F., Büller H. R. Monitoring therapy with vitamin K antagonists in patients with lupus anticoagulant: effect on different tests for INR determination Journal of thrombosis and thrombolysis 2000;9 (3):263-269 [PubMed]

1999

• Mainardi J. R., Pelsma P. M., Koning H., van der Meer J., Middeldorp S., Büller H. R., Hamulyák K. Double-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis Blood 1999;94 (5):1828-1829 [PubMed]
• Meinardi J. R., Middeldorp S., de Kam P. J., Koopman M. M., van Pampus E. C., Hamulyák K., Prins M. H., Büller H. R., van der Meer J. Increased risk for fetal loss in carriers of the factor V Leiden mutation Annals of internal medicine 1999;130 (9):736-739 [PubMed]
• Rosing J., Middeldorp S., Curvers J., Christella M., Thomassen L. G., Nicolaes G. A., Meijers J. C., Bouma B. N., Büller H. R., Prins M. H., Tans G. Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study Lancet 1999;354 (9195):2036-2040 [PubMed]
• Levi M. [=Marcel M.], Middeldorp S., Büller H. R. Oral contraceptives and hormonal replacement therapy cause an imbalance in coagulation and fibrinolysis which may explain the increased risk of venous thromboembolism Cardiovascular research 1999;41 (1):21-24 [PubMed]

1998

• de Winter R. J., Middeldorp S., Gaffar S., Koch K. T., Piek J. J., Levi M. [=Marcel M.], Reitsma P. H. Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation Catheterization and cardiovascular diagnosis 1998;44 (4):427-430 [PubMed]
• Middeldorp S., van der Meer J. Factor V:Q506 mutation-resistance to activated protein C (APC): clinical implications with respect to family screening Seminars in thrombosis and hemostasis 1998;24 (4):363-366 [PubMed]
• Middeldorp S., Henkens C. M., Koopman M. M., van Pampus E. C., Hamulyák K., van der Meer J., Prins M. H., Büller H. R. The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis Annals of internal medicine 1998;128 (1):15-20 [PubMed]