Prof. MD PhD S.T. Pals publications

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Publications Prof. MD PhD S.T. Pals

Position
Full Professor
Main activities
Education, Patient care, Research
Specialisation
Pathology
Focus of research

“We are exploring the interactions between malignant B cells and their microenvironment since these represent the Achilles’ heel of these cancers”

 

Professor dr S.T. Pals (Steven) MD, PhD

 

KEY KNOWLEDGE AREAS:
Malignant lymphoma, Multiple Myeloma (Kahler's disease), Lymphocyte homing, Adhesion molecules, Intracellular signalling.

 

RESEARCH FOCUS:
The research themes of the Immuno- and Hematopathology laboratory are “B-cell development and neoplasia” and “Cell adhesion and migration in inflammation and cancer”. Our mission is: i) to advance the insight into the fundamental biological processes underlying B cell development and cell migration; ii) to acquire knowledge required to improve the diagnosis and treatment of B cell malignancies and to control inflammation and cancer metastasis.

 

CLINICAL AND INDUSTRY RELEVANCE:
Malignant Lymphoma and Multiple Myeloma are common cancers with a high patient morbidity and mortality. Genetic defects in concert with cues from the tumor microenvironment activate signalling pathways that drive tumor growth, survival, and dissemination. Targeting these pathways by small-molecule drugs and antibodies has recently been shown to be highly effective in Lymphoma and Myeloma treatment. In our laboratory, new targets are being explored by in vitro studies as well as in by employing mouse models.

 

RESEARCHER'S BRIEF:
“In the past, workers in a Pathology department like ours would visually inspect patient tissue for signs of disease. Now we are actually delving into the molecular details of pathologies, lymphoma and multiple myeloma in our case. Some very complex and highly interesting details are coming to light. We know now that both normal and malignant B cells require 'homing receptors' to direct them to specific tissues or organs, where they recognize ‘address molecules’. Once arrived, the B cells are highly dependent on the microenvironment for their growth and survival; we are exploring which environmental cues are crucial.  We thusfar discovered that WNTs and hepatocyte growth factor (HGF) support Multiple Myeloma growth, and also promote the bone damage typically seen in this disease. Moreover, recent studies from our laboratory have shown that interfering with the homing and retention of malignant B cells is a highly effective treatment for patients with several types of non-Hodgkin's lymphoma, including chronic  lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldestrom Macroglobilinemia. Specifically, we demonstrated that the impressive therapeutic effect of the  "break through" Bruton's tyrosine kinase (BTK) inhibitor ibrutinib and the PI3Kd inhibitor idelalisib is largely based on induction of cell death by anoikis (homelessness). 

 

RESEARCHER'S QUALIFICATIONS, EXPERIENCE:
Professor of Immuno- and Hematopathology. MD, PhD, Head Molecular Immuno- and Hematopathology laboratory. STP is member of the Scientific Board of the Dutch Cancer Society, and the Scientific Advisory Board for the Fight against Cancer of the Royal Dutch Academy of Science.

 

2020

  • Vermaat Joost S., Somers Sebastiaan F., de Wreede Liesbeth C., Kraan Willem, de Groen Ruben A. L., Schrader Anne M. R., Kerver Emile D., Scheepstra Cornelis G., Berenschot Henriëtte, Deenik Wendy, Wegman Jurgen, Broers Rianne, de Boer Jan-Paul D., Nijland Marcel, van Wezel Tom, Veelken Hendrik, Spaargaren Marcel, Cleven Arjen H., Kersten Marie José, Pals Steven T. MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis Haematologica 2020;105 (2):424-434 [PubMed]

2019

  • van Andel Harmen, Kocemba Kinga A., Spaargaren Marcel, Pals Steven T. Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options Leukemia 2019;33 (5):1063-1075 [PubMed]
  • Ren Zemin Heparan sulfate proteoglycans: key moderators of the interaction of multiple myeloma with the bone marrow niche 2019. 154p. ISBN 9789463752404. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
  • Schreurs Renée R. C. E., Baumdick Martin E., Sagebiel Adrian F., Kaufmann Max, Mokry Michal, Klarenbeek Paul L., Schaltenberg Nicola, Steinert Fenja L., van Rijn Jorik M., Drewniak Agata, The Sarah-May M. L., Bakx Roel, Derikx Joep P. M., de Vries Niek, Corpeleijn Willemijn E., Pals Steven T., Gagliani Nicola, Friese Manuel A., Middendorp Sabine, Nieuwenhuis Edward E. S., Reinshagen Konrad, Geijtenbeek Teunis B. H., van Goudoever Johannes B., Bunders Madeleine J. Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life Immunity 2019;50 (2):462-476.e8 [PubMed]
  • Joosten Sander P. J., Mizutani Tomohiro, Spaargaren Marcel, Clevers Hans, Pals Steven T. MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance Gastroenterology 2019;157 (4):1153-1155.e1 [PubMed]
  • de Groen Ruben A. L., Schrader Anne M. R., Kersten Marie José, Pals Steven T., Vermaat Joost S. P. MYD88 in the driver's seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications Haematologica 2019;104 (12):2337-2348 [PubMed]
  • Vos Josephine M. I. On Waldenström’s macroglobulinemia and IgM related disorders 2019. 153p. ISBN 9789463612111. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Kersten M.J. , Pals S. T.; Co-supervisors: Treon S. P. , Minnema M. C.)
  • Bruggeman Christine W., Houtzager Julia, Dierdorp Barbara, Kers Jesper, Pals Steven T., Lutter René, van Gulik Thomas, den Haan Joke M. M., van den Berg Timo K., van Bruggen Robin, Kuijpers Taco W. Tissue-specific expression of IgG receptors by human macrophages ex vivo PLoS ONE 2019;14 (10) [PubMed]
  • van Andel Harmen Wnt signaling in the pathogenesis of multiple myeloma 2019. 298p. ISBN 9789463753869. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2018

  • Vlijm-Kievit Anniek, Jorna Nori G. E., Moll Etelka, Pajkrt Eva, Pals Steven T., Middeldorp Saskia, Biemond Bart J., Zeerleder Sacha S., Tio Marieke A., Kemper E. Marleen, Hazenberg Mette D. Acute lymphoblastic leukemia during the third trimester of pregnancy Leukemia & lymphoma 2018;59 (5):1274-1276 [PubMed]
  • Nijland Marieke L., Koens Lianne, Pals Steven T., ten Berge Ineke J. M., Bemelman Frederike J., Kersten Marie José Clinicopathological characteristics of T-NHL arising in patients with immunodeficiencies: a single-center case series of 25 patients and a review of the literature Haematologica 2018;103 (3):486-496 [PubMed]
  • Schrader Anne M. R., Jansen Patty M., Willemze Rein, Vermeer Maarten H., Cleton-Jansen Anne-Marie, Somers Sebastiaan F., Veelken Hendrik, van Eijk Ronald, Kraan Willem, Kersten Marie José, van den Brand Michiel, Stevens Wendy B. C., de Jong Daphne, Hamid Myrurgia Abdul, Tanis Bea C., Posthuma Eduardus F. M., Nijland Marcel, Diepstra Arjan, Pals Steven T., Cleven Arjen H. G., Vermaat Joost S. P. High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma Blood 2018;131 (18):2086-2089 [PubMed]
  • Vos Josephine Mathilde, Notermans Nicolette C., D'Sa Shirley, Lunn Michael P., van der Pol W. Ludo, Kraan Willem, Reilly Mary M., Chalker Jane, Gupta Rajeev, Kersten Marie-José, Pals Steven T., Minnema Monique C. High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy Journal of neurology, neurosurgery, and psychiatry 2018;89 (9):1007-1009 [PubMed]
  • Mulder Callista L., Catsburg Lisa A. E., Zheng Yi, de Winter-Korver Cindy M., van Daalen Saskia K. M., van Wely Madelon, Pals Steven, Repping Sjoerd, van Pelt Ans M. M. Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells Human reproduction (Oxford, England) 2018;33 (1):81-90 [PubMed]
  • Ren Zemin, van Andel Harmen, de Lau Wim, Hartholt Robin B., Maurice Madelon M., Clevers Hans, Kersten Marie José, Spaargaren Marcel, Pals Steven T. Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins Blood 2018;131 (9):982-944 [PubMed]

2017

  • van Andel Harmen, Ren Zemin, Koopmans Iris, Joosten Sander P. J., Kocemba Kinga A., de Lau Wim, Kersten Marie José, de Bruin Alexander M., Guikema Jeroen E. J., Clevers Hans, Spaargaren Marcel, Pals Steven T. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins Proceedings of the National Academy of Sciences of the United States of America 2017;114 (2):376-381 [PubMed]
  • Kuijpers Taco W., Tool Anton T. J., van der Bijl Ivo, de Boer Martin, van Houdt Michel, de Cuyper Iris M., Roos Dirk, van Alphen Floris, van Leeuwen Karin, Cambridge Emma L., Arends Mark J., Dougan Gordon, Clare Simon, Ramirez-Solis Ramiro, Pals Steven T., Adams David J., Meijer Alexander B., van den Berg Timo K. Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency Journal of allergy and clinical immunology 2017;140 (1):273-+ [PubMed]
  • Vos Josephine M., Tsakmaklis Nickolas, Patterson Christopher J., Meid Kirsten, Castillo Jorge J., Brodsky Philip, Ganz Tomas, Pals Steven T., Kersten Marie José, Xu Lian, Yang Guang, Treon Steven P., Hunter Zachary R. CXCL13 levels are elevated in patients with Waldenstrom macroglobulinemia, and are predictive of major response to ibrutinib Haematologica 2017;102 (11):E452-E455 [PubMed]
  • van Andel H., Kocemba K. A., de Haan-Kramer A., Mellink C. H., Piwowar M., Broijl A., van Duin M., Sonneveld P., Maurice M. M., Kersten M. J., Spaargaren M., Pals S. T. Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease Oncogene 2017;36 (15):2105-2115 [PubMed]
  • Joosten Sander P. J., Zeilstra Jurrit, van Andel Harmen, Mijnals R. Clinton, Zaunbrecher Joost, Duivenvoorden Annet A. M., van de Wetering Marc, Clevers Hans, Spaargaren Marcel, Pals Steven T. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms Gastroenterology 2017;153 (4):1040-+ [PubMed]
  • Oud Machteld M., Tuijnenburg Paul, Hempel Maja, van Vlies Naomi, Ren Zemin, Ferdinandusse Sacha, Jansen Machiel H., Santer René, Johannsen Jessika, Bacchelli Chiara, Alders Marielle, Li Rui, Davies Rosalind, Dupuis Lucie, Cale Catherine M., Wanders Ronald J. A., Pals Steven T., Ocaka Louise, James Chela, Müller Ingo, Lehmberg Kai, Strom Tim, Engels Hartmut, Williams Hywel J., Beales Phil, Roepman Ronald, Dias Patricia, Brunner Han G., Cobben Jan-Maarten, Hall Christine, Hartley Taila, Le Quesne Stabej Polona, Mendoza-Londono Roberto, Davies E. Graham, de Sousa Sérgio B., Lessel Davor, Arts Heleen H., Kuijpers Taco W. Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome American journal of human genetics 2017;100 (2):281-296 [PubMed]
  • de Rooij Martin F. M. Targeting the BCR signalosome in B cell malignancies 2017. 209p. ISBN 9789462997462. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
  • van Keimpema Martine, Grüneberg Leonie J., Schilder-Tol Esther J. M., Oud Monique E. C. M., Beuling Esther, Hensbergen Paul J., de Jong Johann, Pals Steven T., Spaargaren Marcel The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells Haematologica 2017;102 (3):573-583 [PubMed]

2016

  • Gillissen M. A., de Jong G., Levie S. E., Yasuda E., Bakker A. Q., Evers L. M., Pals S. T., Huisman C., van Helden P. M., Spits H., Hazenberg M. D. AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses Bone marrow transplantation 2016;51 (9):1245-1248 [PubMed]
  • Vos Josephine M. I., Kersten Marie-Jose, Kraan Willem, Groeneveld Onno N., Linn Cisca, Pals Steven T., Minnema Monique C. Effective treatment of Bing-Neel Syndrome with oral fludarabine: a case series of four consecutive patients British journal of haematology 2016;172 (3):461-464 [PubMed]
  • Nijland Marieke L., Kersten Marie José, Pals Steven T., Bemelman Frederike J., ten Berge Ineke J. M. Epstein-Barr Virus-Positive Posttransplant Lymphoproliferative Disease After Solid Organ Transplantation: Pathogenesis, Clinical Manifestations, Diagnosis, and Management Transplantation direct 2016;2 (1):e48 [PubMed]
  • de Rooij Martin F. M., Kuil Annemieke, Kraan Willem, Kersten Marie José, Treon Steven P., Pals Steven T., Spaargaren Marcel Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia Haematologica 2016;101 (3):e111-e115 [PubMed]
  • Pals Steven T., Kersten Marie José, Spaargaren Marcel Targeting cell adhesion and homing as strategy to cure Waldenström's macroglobulinemia Best practice & research. Clinical haematology 2016;29 (2):161-168 [PubMed]

2015

  • Nieuwenhuis Marieke B. B., van der Salm Sandra M. A., Verhoeff Joost J. C., van der Kooi Anneke J., Slavujecvic-Letic Ivana, Pals Steven T., Vos Josephine M. I. A 43-Year-Old Female with Multifocal Cerebral Lesions. Histiocytic Sarcoma Brain pathology (Zurich, Switzerland) 2015;25 (3):371-372 [PubMed]
  • Montgomery Michael, van Santen Marije M., Biemond Bart J., Diamond Robert H., Pals Steven T. Hepatosplenic T-Cell Lymphoma: A Population-Based Study Assessing Incidence and Association With Immune-Mediated Disease Gastroenterology & hepatology 2015;11 (3):160-163 [PubMed]
  • de Rooij Martin F. M., Kuil Annemieke, Kater Arnon P., Kersten Marie José, Pals Steven T., Spaargaren Marcel Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy Blood 2015;125 (14):2306-2309 [PubMed]
  • Vermaat Joost S., Pals Steven T., Younes Anas, Dreyling Martin, Federico Massimo, Aurer Igor, Radford John, Kersten Marie José Precision medicine in diffuse large B-cell lymphoma: hitting the target Haematologica 2015;100 (8):989-993 [PubMed]
  • van Keimpema Martine, Grüneberg Leonie J., Mokry Michal, van Boxtel Ruben, van Zelm Menno C., Coffer Paul, Pals Steven T., Spaargaren Marcel The forkhead transcription factor FOXP1 represses human plasma cell differentiation Blood 2015;126 (18):2098-2109 [PubMed]
  • van Keimpema Martine The FOX and the mutants in mature human B cells and DLBCL: The role of FOXP1 in mature human B cell biology and lymphomagenesis & prevalence of oncogenic MyD88 and CD79B mutations in diffuse large B cell lymphoma 2015. 213p. ISBN 9789462991866. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2014

  • Kersten M. J., Kraan W., Doorduijn J., Bromberg J., Lam K., Kluin P. M., van der Holt B. J., Spaargaren M., Pals S. T. Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations Blood cancer journal 2014;4:e266 [PubMed]
  • van Keimpema Martine, Grüneberg Leonie J., Mokry Michal, van Boxtel Ruben, Koster Jan, Coffer Paul J., Pals Steven T., Spaargaren Marcel FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells Blood 2014;124 (23):3431-3440 [PubMed]
  • Kraan W., van Keimpema M., Horlings H. M., Schilder-Tol E. J. M., Oud M. E. C. M., Noorduyn L. A., Kluin P. M., Kersten M. J., Spaargaren M., Pals S. T. High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma Leukemia 2014;28 (3):719-720 [PubMed]
  • Rampanelli Elena, Rouschop Kasper M. A., Claessen Nike, Teske Gwendoline J. D., Pals Steven T., Leemans Jaklien C., Florquin Sandrine Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy Kidney international 2014;86 (3):558-569 [PubMed]
  • Zeilstra J., Joosten S. P. J., van Andel H., Tolg C., Berns A., Snoek M., van de Wetering M., Spaargaren M., Clevers H., Pals S. T. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling Oncogene 2014;33 (5):665-670 [PubMed]
  • Kocemba Kinga A. The bone marrow niche in the pathogenesis of multiple myeloma: A role for Wnt signaling and adrenomedullin 2014. 223p. ISBN 9788363861162. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2013

  • Aan de Kerk Daan J., van Leeuwen Ester M. M., Jansen Machiel H., van den Berg J. Merlijn, Alders Marielle, Vermont Clementine L., van Lier René A. W., Pals Steven T., Kuijpers Taco W. Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis Clinical immunology (Orlando, Fla.) 2013;149 (1):25-31 [PubMed]
  • Hovius Joppe W. R., de Wever Bob, Sohne Maaike, Brouwer Matthijs C., Coumou Jeroen, Wagemakers Alex, Oei Anneke, Knol Henrike, Narasimhan Sukanya, Hodiamont Caspar J., Jahfari Setareh, Pals Steven T., Horlings Hugo M., Fikrig Erol, Sprong Hein, van Oers Marinus H. J. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe Lancet 2013;382 (9892):658 [PubMed]
  • Rampanelli Elena, Dessing Mark C., Claessen Nike, Teske Gwendoline J. D., Joosten Sander P. J., Pals Steven T., Leemans Jaklien C., Florquin Sandrine CD44-deficiency attenuates the immunologic responses to LPS and delays the onset of endotoxic shock-induced renal inflammation and dysfunction PLoS ONE 2013;8 (12):e84479 [PubMed]
  • Zeilstra Jurrit, Joosten Sander P. J., Vermeulen Louis, Koster Jan, Medema Jan Paul, Versteeg Rogier, Spaargaren Marcel, Pals Steven T. CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status PLoS ONE 2013;8 (8):e72849 [PubMed]
  • Lascano Valeria, Guadagnoli Marco, Schot Jan G., Luijks Dieuwertje M., Guikema Jeroen E. J., Cameron Katherine, Hahne Michael, Pals Steven, Slinger Erik, Kipps Thomas J., van Oers Marinus H. J., Eldering Eric, Medema Jan Paul, Kater Arnon P. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model Blood 2013;122 (24):3960-3963 [PubMed]
  • Bot Pieter T., Grundmann Sebastian, van Royen Niels, Joosten Sander P. J., Schirmer Stephan H., de kleijn Dominique P. V., Pals Steven T., Pasterkamp Gerard, Piek Jan J., Hoefer Imo E. Distinct CD44 splice variants differentially affect collateral artery growth Current vascular pharmacology 2013;11 (1):13-20 [PubMed]
  • Chang Betty Y., Francesco Michelle, de Rooij Martin F. M., Magadala Padmaja, Steggerda Susanne M., Huang Min Mei, Kuil Annemieke, Herman Sarah E. M., Chang Stella, Pals Steven T., Wilson Wyndham, Wiestner Adrian, Spaargaren Marcel, Buggy Joseph J., Elias Laurence Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients Blood 2013;122 (14):2412-2424 [PubMed]
  • Vos J. M. I., Minnema M. C., Wijermans P. W., Croockewit S., Chamuleau M. E. D., Pals S. T., Klein S. K., Delforge M., van Imhoff G. W., Kersten M. J. Guideline for diagnosis and treatment of Waldenström's macroglobulinaemia Netherlands journal of medicine 2013;71 (2):54-62 [PubMed]
  • Reijmers Rogier M., Spaargaren Marcel, Pals Steven T. Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma FEBS journal 2013;280 (10):2180-2193 [PubMed]
  • Kraan W., Horlings H. M., van Keimpema M., Schilder-Tol E. J. M., Oud M. E. C. M., Scheepstra C., Kluin P. M., Kersten M. J., Spaargaren M., Pals S. T. High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites Blood cancer journal 2013;3:e139 [PubMed]
  • Pascutti Maria Fernanda, Jak Margot, Tromp Jacqueline M., Derks Ingrid A. M., Remmerswaal Ester B. M., Thijssen Rachel, van Attekum Martijn H. A., van Bochove Gregor G., Luijks Dieuwertje M., Pals Steven T., van Lier René A. W., Kater Arnon P., van Oers Marinus H. J., Eldering Eric IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells Blood 2013;122 (17):3010-3019 [PubMed]
  • Kocemba K. A., van Andel H., de Haan-Kramer A., Mahtouk K., Versteeg R., Kersten M. J., Spaargaren M., Pals S. T. The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis Leukemia 2013;27 (8):1729-1737 [PubMed]

2012

  • van Maldegem F., Wormhoudt T. A. M., Mulder M. M. S., Oud M. E. C. M., Schilder-Tol E., Musler A. R., Aten J., Saeed P., Kersten M. J., Pals S. T., van Noesel C. J. M., Bende R. J. Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased V(H)4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment Leukemia 2012;26 (7):1647-1653 [PubMed]
  • Bunders Madeleine J., van der Loos Chris M., Klarenbeek Paul L., van Hamme John L., Boer Kees, Wilde Jim C. H., de Vries Niek, van Lier Rene A. W., Kootstra Neeltje, Pals Steven T., Kuijpers Taco W. Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1 Blood 2012;120 (22):4383-4390 [PubMed]
  • Vos J. M., Minnema M. C., Wijermans P. W., Croockewit S., Chamuleau M. E., Pals S. T., Klein S. K., Delforge M., van Imhoff G. W., Kersten M. J. Richtlijn voor diagnostiek en behandeling van de ziekte van Waldenström Nederlands tijdschrift voor hematologie 2012;9:219
  • de Rooij Martin F. M., Kuil Annemieke, Geest Christian R., Eldering Eric, Chang Betty Y., Buggy Joseph J., Pals Steven T., Spaargaren Marcel The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia Blood 2012;119 (11):2590-2594 [PubMed]
  • Kocemba Kinga A., Groen Richard W. J., van Andel Harmen, Kersten Marie José, Mahtouk Karène, Spaargaren Marcel, Pals Steven T. Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma PLoS ONE 2012;7 (2):e30359 [PubMed]

2011

  • Hazenberg M. D., Biemond B. J., Pals S. T., Zumpolle C. M., Schinkel C. J., Linthorst G. E., Hoekstra J. B. L., Vos J. M. I. Clinical pathological conference: a non-Hodgkin's lymphoma patient with persistent anaemia after chemotherapy Netherlands journal of medicine 2011;69 (10):469-473 [PubMed]
  • Kuijpers Taco W., Baars Paul A., Aan de Kerk Daan J., Jansen Machiel H., Dors Natasja, van Lier Rene A. W., Pals Steven T. Common variable immunodeficiency and hemophagocytic features associated with a FAS gene mutation Journal of allergy and clinical immunology 2011;127 (6):1411-1414 [PubMed]
  • Reijmers Rogier M., Groen Richard W. J., Kuil Annemieke, Weijer Kees, Kimberley Fiona C., Medema Jan Paul, van Kuppevelt Toin H., Li Jin-Ping, Spaargaren Marcel, Pals Steven T. Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival Blood 2011;117 (23):6162-6171 [PubMed]
  • Tonino Sanne H., Rijssenbeek Astrid L., Oud Monique E., Pals Steven T., van Oers Marinus H., Kater Arnon P. Intracerebral Infiltration As the Unique Cause of the Clinical Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia Journal of clinical oncology 2011;29 (34):E837-E839 [PubMed]
  • de Sousa E Melo Felipe, Colak Selcuk, Buikhuisen Joyce, Koster Jan, Cameron Kate, de Jong Joan H., Tuynman Jurriaan B., Prasetyanti Pramudita R., Fessler Evelyn, van den Bergh Saskia P., Rodermond Hans, Dekker Evelien, van der Loos Chris M., Pals Steven T., van de Vijver Marc J., Versteeg Rogier, Richel Dick J., Vermeulen Louis, Medema Jan Paul Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients Cell stem cell 2011;9 (5):476-485 [PubMed]
  • Groen Richard W. J., de Rooij Martin F. M., Kocemba Kinga A., Reijmers Rogier M., de Haan-Kramer Anneke, Overdijk Marije B., Aalders Linda, Rozemuller Henk, Martens Anton C. M., Bergsagel P. Leif, Kersten Marie José, Pals Steven T., Spaargaren Marcel N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation Haematologica 2011;96 (11):1653-1661 [PubMed]
  • Vos J. M. I., Bordbar Arash, Vet Raymond, Pals S. T., Kater A. P. Waxing and waning intravascular large cell lymphoma with widespread organ infiltration Leukemia & lymphoma 2011;52 (4):705-708 [PubMed]
  • Zeilstra Jurrit, Joosten Sander P. J., Wensveen Felix M., Dessing Mark C., Schütze Denise M., Eldering Eric, Spaargaren Marcel, Pals Steven T. WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer Biochemical and biophysical research communications 2011;406 (1):1-6 [PubMed]

2010

  • van Rijssel Reinier H., Wegman Jurgen, Oud Monique E., Pals Steven T., van Oers Marinus H. J. A case of ATRA-induced isolated myocarditis in the absence of circulating malignant cells: Demonstration of the t(15;17) translocation in the inflammatory infiltrate by in situ hybridisation Leukemia research 2010;34 (7):E142-E144 [PubMed]
  • Mahtouk Karene, Moreaux Jerome, Hose Dirk, Reme Thierry, Meissner Tobias, Jourdan Michel, Rossi Jean Francois, Pals Steven T., Goldschmidt Hartmut, Klein Bernard Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays BMC cancer 2010;10 (1):198 [PubMed]
  • Reijmers Rogier M. Heparan sulfate proteoglycans in B cell maturation and myeloma plasma cell survival 2010. 165p. ISBN 9789090256450. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
  • Bot Pieter T., Pasterkamp Gerard, Goumans Marie-José, Strijder Chaylendra, Moll Frans L., de Vries Jean-Paul, Pals Steven T., de Kleijn Dominique P., Piek Jan J., Hoefer Imo E. Hyaluronic acid metabolism is increased in unstable plaques European journal of clinical investigation 2010;40 (9):818-827 [PubMed]
  • Reijmers Rogier M., Vondenhoff Mark F. R., Roozendaal Ramon, Kuil Annemieke, Li Jin-Ping, Spaargaren Marcel, Pals Steven T., Mebius Reina E. Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme Glucuronyl C5-Epimerase Journal of immunology (Baltimore, Md. 2010;184 (7):3656-3664 [PubMed]
  • Groen Richard W. J. Microenvironmental regulation of multiple myeloma and malignant lymphoma. The role of HGF, Wnts, heparan sulfate proteoglycans, and N-cadherin 2010. 199p. ISBN 9789090257686. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)
  • Robertus Jan-Lukas, Kluiver Joost, Weggemans Callista, Harms Geert, Reijmers Rogier M., Swart Yolanthe, Kok Klaas, Rosati Stefano, Schuuring Ed, van Imhoff Gustaaf, Pals Steven T., Kluin Philip, van den Berg Anke MiRNA profiling in B non-Hodgkin lymphoma: a MYC-related miRNA profile characterizes Burkitt lymphoma British journal of haematology 2010;149 (6):896-899 [PubMed]
  • Reijmers Rogier M., Groen Richard W. J., Rozemuller Henk, Kuil Annemieke, de Haan-Kramer Anneke, Csikós Tamás, Martens Anton C. M., Spaargaren Marcel, Pals Steven T. Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma Blood 2010;115 (3):601-604 [PubMed]
  • Kemper Kristel, Sprick Martin R., de Bree Martijn, Scopelliti Alessandro, Vermeulen Louis, Hoek Maarten, Zeilstra Jurrit, Pals Steven T., Mehmet Huseyin, Stassi Giorgio, Medema Jan Paul The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation Cancer research 2010;70 (2):719-729 [PubMed]
  • Mahtouk Karène, Tjin Esther P. M., Spaargaren Marcel, Pals Steven T. The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 2010;1806 (2):208-219 [PubMed]

2009

  • Iyer Anand M. Immunology of leprosy. Towards the search for diagnostic and prognostic biomarkers elucidating pathobiology and their utility in patient care 2009. 167p. ISBN 9789064643255. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Pals S. T., Das P. K.; Co-supervisor: Faber W. R.)
  • Tan Lu Ping, Wang Miao, Robertus Jan-Lukas, Schakel Rikst Nynke, Gibcus Johan H., Diepstra Arjan, Harms Geert, Peh Suat-Cheng, Reijmers Rogier M., Pals Steven T., Kroesen Bart-Jan, Kluin Philip M., Poppema Sibrand, van den Berg Anke miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes Laboratory investigation; a journal of technical methods and pathology 2009;89 (6):708-716 [PubMed]

2008

  • Zeilstra Jurrit, Joosten Sander P. J., Dokter Maarten, Verwiel Eugène, Spaargaren Marcel, Pals Steven T. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis Cancer research 2008;68 (10):3655-3661 [PubMed]
  • Groen Richard W. J., Oud Monique E. C. M., Schilder-Tol Esther J. M., Overdijk Marije B., ten Berge Derk, Nusse Roel, Spaargaren Marcel, Pals Steven T. Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies Cancer research 2008;68 (17):6969-6977 [PubMed]
  • de Fost M., Out T. A., de Wilde F. A., Tjin E. P. M., Pals S. T., van Oers M. H. J., Boot R. G., Aerts J. F. M. G., Maas M., vom Dahl S., Hollak C. E. M. Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature Annals of hematology 2008;87 (6):439-449 [PubMed]
  • Csikós Tamás, Reijmers Rogier M., Uren Anthony G., Spaargaren Marcel, Pals Steven T. Instant conditional transgenesis in the mouse hematopoietic compartment Journal of immunological methods 2008;339 (2):259-263 [PubMed]
  • de Gorter David J. J. Signaling pathways involved in B cell differentiation and disease. The role of Ral, Btk and Met 2008. 160p. ISBN 9789090228907. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals Steven T.; Co-supervisor: Spaargaren M.)
  • de Gorter David J. J., Reijmers Rogier M., Beuling Esther A., Naber Hildegonda P. H., Kuil Annemieke, Kersten Marie José, Pals Steven T., Spaargaren Marcel The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells Blood 2008;111 (7):3364-3372 [PubMed]

2007

  • de Gorter David J. J., Beuling Esther A., Kersseboom Rogier, Middendorp Sabine, van Gils Janine M., Hendriks Rudolf W., Pals Steven T., Spaargaren Marcel Bruton's tyrosine kinase and phospholipase C gamma 2 mediate chemokine-controlled B cell migration and homing Immunity 2007;26 (1):93-104 [PubMed]
  • Pals Steven T., de Gorter David J. J., Spaargaren Marcel Lymphoma dissemination: the other face of lymphocyte homing Blood 2007;110 (9):3102-3111 [PubMed]
  • Evans P. A. S., Pott Ch, Groenen P. J. T. A., Salles G., Davi F., Berger F., Garcia J. F., van Krieken J. H. J. M., Pals S., Kluin Ph, Schuuring E., Spaargaren M., Boone E., González D., Martinez B., Villuendas R., Gameiro P., Diss T. C., Mills K., Morgan G. J., Carter G. I., Milner B. J., Pearson D., Hummel M., Jung W., Ott M., Canioni D., Beldjord K., Bastard C., Delfau-Larue M. H., van Dongen J. J. M., Molina T. J., Cabeçadas J. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936 Leukemia 2007;21 (2):207-214 [PubMed]
  • de Gorter David J. J., Vos Johanna C. M., Pals Steven T., Spaargaren Marcel The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral Journal of immunology (Baltimore, Md. 2007;178 (3):1405-1414 [PubMed]

2006

  • Boon Elles M. J., Pouwels Walter, Redeker Sandra, Joosten Sander P. J., Hamann Jörg, van der Neut Ronald, Pals Steven T. Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met Cancer science 2006;97 (8):710-715 [PubMed]
  • Rouschop Kasper M. A., Claessen Nike, Pals Steven T., Weening Jan J., Florquin Sandrine CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis Journal of the American Society of Nephrology 2006;17 (3):746-753 [PubMed]
  • Rouschop K. M. A. CD44 in renal disease: friend or foe? 2006. 171p. ISBN 9789052910956. [UvA Dissertations Online] University of Amsterdam. (Supervisors: Weening J. J., Pals S. T.; Co-supervisor: Florquin S.)
  • Hoefnagel Juliette J., Mulder Marÿn M. S., Dreef Enno, Jansen Patty M., Pals Steven T., Meijer Chris J. L. M., Willemze Rein, Vermeer Maarten H. Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma Modern pathology 2006;19 (9):1270-1276 [PubMed]
  • Tjin Esther P. M., Groen Richard W. J., Vogelzang Irma, Derksen Patrick W. B., Klok Melanie D., Meijer Helen P., van Eeden Susanne, Pals Steven T., Spaargaren Marcel Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma Blood 2006;107 (2):760-768 [PubMed]
  • Mulder Marijn M. S., Heddema Edou R., Pannekoek Yvonne, Faridpooya Koorosh, Oud Monique E. C. M., Schilder-Tol Esther, Saeed Peerooz, Pals Steven T. No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands Leukemia research 2006;30 (10):1305-1307 [PubMed]
  • Faridpooya K., Mulder M. M. S., Merks J. H. M., de Smet M. D., Pals S. T., Saeed P. Precursor B lymphoblastic lymphoma of the orbit in a child: an unusual presentation of a non-Hodgkin lymphoma Orbit (Amsterdam, Netherlands) 2006;25 (2):153-157 [PubMed]
  • Boon E. M. J. The HGF/MET pathway in colorectal cancer 2006. 120p. ISBN 9789073838666. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: van der Neut R.)
  • Rouschop Kasper M. A., Sylva Marc, Teske Gwendoline J. D., Hoedemaeker Inge, Pals Steven T., Weening Jan J., van der Poll Tom, Florquin Sandrine Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract Journal of immunology (Baltimore, Md. 2006;177 (10):7225-7232 [PubMed]

2005

  • Bende Richard J., Aarts Wilhelmina M., Riedl Robert G., de Jong Daphne, Pals Steven T., van Noesel Carel J. M. Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity Journal of experimental medicine 2005;201 (8):1229-1241 [PubMed]
  • Batlle Eduard, Bacani Julinor, Begthel Harry, Jonkheer Suzanne, Jonkeer Suzanne, Gregorieff Alexander, van de Born Maaike, Malats Núria, Sancho Elena, Boon Elles, Pawson Tony, Gallinger Steven, Pals Steven, Clevers Hans EphB receptor activity suppresses colorectal cancer progression Nature 2005;435 (7045):1126-1130 [PubMed]
  • Batlle E., Bacani J., Begthel H., Jonkheer S., Gregorieff A., van de Born M., Malats N., Sancho E., Boon E., Pawson T., Gallinger S., Pals S., Clevers H. EphB receptor activity suppresses colorectal cancer progression (vol 435, pg 1126, 2005) Nature 2005;436 (7052):881
  • Tjin Esther P. M., Bende Richard J., Derksen Patrick W. B., van Huijstee Anne-Pauline, Kataoka Hiroaki, Spaargaren Marcel, Pals Steven T. Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator Journal of immunology (Baltimore, Md. 2005;175 (5):2807-2813 [PubMed]
  • Hendriks J., Planelles L., de Jong-Odding J., Hardenberg G., Pals S. T., Hahne M., Spaargaren M., Medema J. P. Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation Cell death and differentiation 2005;12 (6):637-648 [PubMed]
  • Deloose S. T. P., Smit L. A., Pals F. T., Kersten M.-J., van Noesel C. J. M., Pals S. T. High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma Leukemia 2005;19 (5):851-855 [PubMed]
  • Songun I., Litvinov S. V., van de Velde C. J. H., Pals S. T., Hermans J., van Krieken J. H. J. M. Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer British journal of cancer 2005;92 (9):1767-1772 [PubMed]
  • Rouschop Kasper M. A., Roelofs Joris J. T. H., Claessen Nike, da Costa Martins Paula, Zwaginga Jaap-Jan, Pals Steven T., Weening Jan J., Florquin Sandrine Protection against renal ischemia reperfusion injury by CD44 disruption Journal of the American Society of Nephrology 2005;16 (7):2034-2043 [PubMed]
  • Tjin E. P. M. The HFG/MET and WNT signaling pathways in B cell differentiation and neoplasia 2005. 123p. ISBN 9789090198965. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.; Co-supervisor: Spaargaren M.)

2004

  • Rouschop Kasper M. A., Sewnath Miguel E., Claessen Nike, Roelofs Joris J. T. H., Hoedemaeker Inge, van der Neut Ronald, Aten Jan, Pals Steven T., Weening Jan J., Florquin Sandrine CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy Journal of the American Society of Nephrology 2004;15 (3):674-686 [PubMed]
  • van Royen N., Voskuil M., Hoefer I., Jost M., de Graaf S., Hedwig F., Andert J.-P., Wormhoudt T. A. M., Hua J., Hartmann S., Bode C., Buschmann I., Schaper W., van der Neut R., Piek J. J., Pals S. T. CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization Circulation 2004;109 (13):1647-1652 [PubMed]
  • Derksen Patrick W. B., Tjin Esther, Meijer Helen P., Klok Melanie D., MacGillavry Harold D., van Oers Marinus H. J., Lokhorst Henk M., Bloem Andries C., Clevers Hans, Nusse Roel, van der Neut Ronald, Spaargaren Marcel, Pals Steven T. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells Proceedings of the National Academy of Sciences of the United States of America 2004;101 (16):6122-6127 [PubMed]
  • Tjin Esther P. M., Derksen Patrick W. B., Kataoka Hiroaki, Spaargaren Marcel, Pals Steven T. Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator Blood 2004;104 (7):2172-2175 [PubMed]
  • Boon E. M. J., Keller J. J., Wormhoudt T. A. M., Giardiello F. M., Offerhaus G. J. A., van der Neut R., Pals S. T. Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines British journal of cancer 2004;90 (1):224-229 [PubMed]

2003

  • Leemans Jaklien C., Florquin Sandrine, Heikens Mirjam, Pals Steven T., van der Neut Ronald, van der Poll Tom CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis Journal of clinical investigation 2003;111 (5):681-689 [PubMed]
  • Bende Richard J., Smit Laura A., Bossenbroek Janneke G., Aarts Wilhelmina M., Spaargaren Marcel, de Leval Laurence, Boeckxstaens Guy E. E., Pals Steven T., van Noesel Carel J. M. Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells American journal of pathology 2003;162 (1):105-113 [PubMed]
  • Derksen P. W. B. Regulation of cell growth in Multiple Myeloma: a role for the HGF/MET and WNT signaling pathways 2003. 119p. ISBN 9789064648793. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.)
  • Kuijpers T. W., Ridanpää M., Peters M., de Boer I., Vossen J. M. J. J., Pals S. T., Kaitila I., Hennekam R. C. M. Short-limbed dwarfism with bowing, combined immune deficiency, and late onset aplastic anaemia caused by novel mutations in the RMPR gene Journal of medical genetics 2003;40 (10):761-766 [PubMed]
  • Spaargaren Marcel, Beuling Esther A., Rurup Mette L., Meijer Helen P., Klok Melanie D., Middendorp Sabine, Hendriks Rudolf W., Pals Steven T. The B cell antigen receptor controls integrin activity through Btk and PLCgamma2 Journal of experimental medicine 2003;198 (10):1539-1550 [PubMed]
  • Derksen P. W. B., de Gorter D. J. J., Meijer H. P., Bende R. J., van Dijk M., Lokhorst H. M., Bloem A. C., Spaargaren M., Pals S. T. The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma Leukemia 2003;17 (4):764-774 [PubMed]

2002

  • Taher Taher E. I., Tjin Esther P. M., Beuling Esther A., Borst Jannie, Spaargaren Marcel, Pals Steven T. c-Cbl is involved in met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination Journal of immunology (Baltimore, Md. 2002;169 (7):3793-3800 [PubMed]
  • Taher T. E. I. CD44 and Met: the signaling perspective 2002. 202p. [UvA Dissertations Online] University of Amsterdam. (Supervisor: Pals S. T.)
  • Florquin Sandrine, Nunziata Raffaele, Claessen Nike, van den Berg Frank M., Pals Steven T., Weening Jan J. CD44 expression in IgA nephropathy American journal of kidney diseases 2002;39 (2):407-414 [PubMed]
  • Dingemans Koert P., Ramkema Marja D., Pals Steven T. CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas Laboratory investigation; a journal of technical methods and pathology 2002;82 (3):313-322 [PubMed]
  • Derksen Patrick W. B., Keehnen Robert M. J., Evers Ludo M., van Oers Marinus H. J., Spaargaren Marcel, Pals Steven T. Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma Blood 2002;99 (4):1405-1410 [PubMed]
  • Taher Taher E. I., Derksen Patrick W. B., de Boer Onno J., Spaargaren Marcel, Teeling Peter, van der Wal Allard C., Pals Steven T. Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration Biochemical and biophysical research communications 2002;298 (1):80-86 [PubMed]
  • Rentenaar Rob J., van Diepen Frank N. J., Meijer René T., Surachno Sugianto, Wilmink Joep M., Schellekens Peter Th A., Pals Steven T., van Lier René A. W., ten Berge Ineke J. M. Immune responsiveness in renal transplant recipients: mycophenolic acid severely depresses humoral immunity in vivo Kidney international 2002;62 (1):319-328 [PubMed]
  • Bende R. J., Aarts W. M., Pals S. T., van Noesel C. J. M. Immunoglobulin diversification in B cell malignancies: internal splicing of heavy chain variable region as a by-product of somatic hypermutation Leukemia 2002;16 (4):636-644 [PubMed]
  • Aarts Wilhelmina M., Bende Richard J., Vaandrager Jan-Willem, Kluin Philip M., Langerak Anton W., Pals Steven T., van Noesel Carel J. M. In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma - Evidence for interfollicular trafficking of tumor cells American journal of pathology 2002;160 (3):883-891 [PubMed]
  • van de Wetering Marc, Sancho Elena, Verweij Cornelis, de Lau Wim, Oving Irma, Hurlstone Adam, van der Horn Karin, Batlle Eduard, Coudreuse Damien, Haramis Anna Pavlina, Tjon-Pon-Fong Menno, Moerer Petra, van den Born Maaike, Soete Gwen, Pals Steven, Eilers Martin, Medema Rene, Clevers Hans The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 2002;111 (2):241-250 [PubMed]
  • Boon Elles M. J., van der Neut Ronald, van de Wetering Marc, Clevers Hans, Pals Steven T. Wnt signaling regulates expression of the receptor tyrosine kinase Met in colorectal cancer Cancer research 2002;62 (18):5126-5128 [PubMed]

2001

  • van den Wijngaard R., Wankowicz-Kalinska A., Pals S., Weening J., Das P. Autoimmune melanocyte destruction in vitiligo Laboratory investigation; a journal of technical methods and pathology 2001;81 (8):1061-1067 [PubMed]
  • Arens R., Tesselaar K., Baars P. A., van Schijndel G. M., Hendriks J., Pals S. T., Krimpenfort P., Borst J., van Oers M. H., van Lier R. A. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion Immunity 2001;15 (5):801-812 [PubMed]
  • Aarts W. M., Bende R. J., Bossenbroek J. G., Pals S. T., van Noesel C. J. Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time Blood 2001;98 (1):238-240 [PubMed]

2000

  • CD44 glycoproteins in colorectal cancer: expression, function, and prognostic value Advances in cancer research 2000;77:169-187 [PubMed]
  • Cell adhesion receptors in lymphoma dissemination Blood 2000;95 (6):1900-1910 [PubMed]
  • Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer American journal of pathology 2000;157 (5):1563-1573 [PubMed]
  • Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans Journal of experimental medicine 2000;192 (8):1115-1124 [PubMed]
  • The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation Advances in cancer research 2000;79:39-90 [PubMed]
  • Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load Blood 2000;95 (9):2922-2929 [PubMed]

1999

  • Aberrant expression and reverse signalling of CD70 on malignant B cells British journal of haematology 1999;106 (2):491-503 [PubMed]
  • Analysis of variable heavy and light chain genes in follicular lymphomas of different heavy chain isotype Current topics in microbiology and immunology 1999;246:217-22; discussion 223-4 [PubMed]
  • CD44 expression predicts disease outcome in localized large B cell lymphoma Leukemia 1999;13 (9):1448-1455 [PubMed]
  • Cross-talk between CD44 and c-Met in B cells Current topics in microbiology and immunology 1999;246:31-7; discussion 38 [PubMed]
  • Epstein-Barr-virus in een donornier als oorzaak van non-Hodgkin-lymfoom Nederlands tijdschrift voor geneeskunde 1999;143 (7):360-364 [PubMed]
  • Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway American journal of pathology 1999;154 (2):515-523 [PubMed]
  • Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met Journal of biological chemistry 1999;274 (10):6499-6506 [PubMed]
  • The expression of CD44 glycoprotein adhesion molecules in basal cell carcinomas is related to growth pattern and invasiveness British journal of dermatology 1999;140 (1):17-25 [PubMed]

1998

  • Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy Journal of virology 1998;72 (1):488-496 [PubMed]
  • CD44 isoforms, including the CD44 V3 variant, are expressed on endothelium, suggesting a role for CD44 in the immobilization of growth factors and the regulation of the local immune response Biochemical and biophysical research communications 1998;245 (1):172-176 [PubMed]
  • CD44 splice variants as prognostic markers in colorectal cancer Scandinavian journal of gastroenterology 1998;33 (1):82-87 [PubMed]
  • Cell adhesion and migration in inflammation and cancer - Preface Cell adhesion and communication 1998;6 (2-3):83-84
  • Expression of Epstein-Barr virus latent genes and adhesion molecules in AIDS-related non-Hodgkin's lymphomas: correlation with histology and CD4-cell number Leukemia & lymphoma 1998;30 (5-6):515-524 [PubMed]
  • Regression of AIDS-related Kaposi's sarcoma associated with clearance of human herpesvirus-8 from peripheral blood mononuclear cells following initiation of antiretroviral therapy AIDS (London, England) 1998;12 (2):218-219 [PubMed]
  • Regulation of adhesion and migration in the germinal center microenvironment Cell adhesion and communication 1998;6 (2-3):111-116 [PubMed]
  • Variation in gut-homing CD27-negative lymphocytes in inflammatory colon disease Scandinavian journal of immunology 1998;48 (3):318-323 [PubMed]
  • VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching Blood 1998;92 (10):3857-3864 [PubMed]

1997

  • Adhesion molecules in atopic dermatitis: patch tests elicited by house dust mite Contact dermatitis 1997;37 (4):163-172 [PubMed]
  • Adhesion molecules in the dissemination of non-Hodgkin's lymphomas Acta haematologica 1997;97 (1-2):73-80 [PubMed]
  • Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation Gut 1997;40 (2):241-246 [PubMed]
  • Antigen-specific immune responsiveness and lymphocyte recruitment in leukocyte adhesion deficiency type II International immunology 1997;9 (4):607-613 [PubMed]
  • Differential expression of CD44 splice variants in the normal human central nervous system Journal of neuroimmunology 1997;73 (1-2):70-76 [PubMed]
  • Expression of adhesion molecules in pagetoid reticulosis (Woringer-Kolopp disease) British journal of dermatology 1997;136 (4):613-616 [PubMed]
  • Expression of granzyme B by cytotoxic T lymphocytes in the lymph nodes of HIV-infected patients AIDS research and human retroviruses 1997;13 (3):227-233 [PubMed]
  • Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95-induced apoptosis European journal of immunology 1997;27 (1):1-7 [PubMed]
  • Increased expression of ICAM-1 and VCAM-1 in the skin after administration of the first dose of OKT3 Transplantation proceedings 1997;29 (1-2):325-327 [PubMed]
  • p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis Histochemical journal 1997;29 (6):439-452 [PubMed]
  • Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway Journal of experimental medicine 1997;185 (12):2121-2131 [PubMed]
  • Preferential expression of the mucosal homing receptor integrin alpha 4 beta 7 in gastrointestinal non-Hodgkin's lymphomas American journal of pathology 1997;150 (3):919-927 [PubMed]
  • Triple check for antigen specificity of B cells during germinal centre reactions Immunology today 1997;18 (12):573-577 [PubMed]

1996

  • A young child with acquired t(8;9)(p11;q34): additional proof that 8p11 is involved in mixed myeloid/T lymphoid malignancies Leukemia 1996;10 (7):1252-1253 [PubMed]
  • Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG) British journal of cancer 1996;74 (11):1783-1788 [PubMed]
  • Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70 European journal of immunology 1996;26 (5):1007-1011 [PubMed]
  • Increased dermal expression of ICAM-1 and VCAM-1 after administration of OKT3 in man Clinical nephrology 1996;46 (2):84-91 [PubMed]
  • Phenotype and function of human B cells expressing CD70 (CD27 ligand) European journal of immunology 1996;26 (12):2964-2971 [PubMed]
  • Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes Journal of biological chemistry 1996;271 (5):2863-2867 [PubMed]

1995

  • Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type Biochemical and biophysical research communications 1995;214 (1):137-144 [PubMed]
  • CD44 in colon cancer European journal of cancer (Oxford, England 1995;31A (7-8):1110-1112 [PubMed]
  • COLORECTAL TUMORIGENESIS - REPLY Gut 1995;36 (5):801
  • Difference in expression of CD44 splice variants between proximal and distal adenocarcinoma of the large bowel British journal of surgery 1995;82 (11):1468-1470 [PubMed]
  • EFFECT OF CD44V6 ON SURVIVAL IN COLORECTAL-CARCINOMA - REPLY Lancet 1995;345 (8945):328
  • Expression of CD44 splice variants in human cutaneous melanoma and melanoma cell lines is related to tumor progression and metastatic potential International journal of cancer. Journal international du cancer 1995;64 (3):182-188 [PubMed]
  • Expression of CD44 splice variants in human primary brain tumors Journal of neuro-oncology 1995;26 (3):185-190 [PubMed]
  • Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis Gut 1995;36 (1):76-80 [PubMed]
  • Splice variants of the cell surface glycoprotein CD44 associated with metastatic tumour cells are expressed in normal tissues of humans and cynomolgus monkeys European journal of cancer (Oxford, England 1995;31A (13-14):2385-2391 [PubMed]
  • The role of CD44 splice variants in human metastatic cancer Ciba Foundation symposium 1995;189:142-51; discussion 151-6, 174-6 [PubMed]

1994

  • Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells Journal of immunology (Baltimore, Md. 1994;152 (8):3760-3767 [PubMed]
  • Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis Blood 1994;84 (5):1415-1420 [PubMed]
  • CD70 represents the human ligand for CD27 International immunology 1994;6 (3):477-480 [PubMed]
  • Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins Lancet 1994;344 (8935):1470-1472 [PubMed]
  • Differential expression of ICAM-1, E-selectin and VCAM-1 by endothelial cells in psoriasis and contact dermatitis Acta dermato-venereologica 1994;74 (Suppl 186):21-22 [PubMed]
  • Expression of CD44 splice variants during lymphocyte activation and tumor progression Cell adhesion and communication 1994;2 (3):195-200 [PubMed]
  • Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine Gastroenterology 1994;107 (5):1519-1523 [PubMed]
  • Functional evidence that the HECA-452 antigen is involved in the adhesion of human neutrophils and lymphocytes to tumour necrosis factor-alpha-stimulated endothelial cells Immunology 1994;81 (3):359-365 [PubMed]
  • Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin Archives of dermatological research 1994;286 (6):304-311 [PubMed]

1993

  • Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44 Journal of experimental medicine 1993;177 (4):897-904 [PubMed]
  • A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps Journal of cell biology 1993;120 (1):227-233 [PubMed]
  • CD44 antibody stimulates adhesion of peripheral blood T cells to keratinocytes through the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway Journal of investigative dermatology 1993;100 (4):424-428 [PubMed]
  • CD44 splice variants: expression during lymphocyte activation and tumor progression Behring Institute Mitteilungen 1993;92:273-277 [PubMed]
  • CD44 splice variants; expression on lymphocytes and in neoplasia Research in immunology 1993;144 (9):750-4; discussion 754-62 [PubMed]
  • CD44 splice variants: metastases meet lymphocytes Immunology today 1993;14 (8):395-399 [PubMed]
  • Expression and release of CD27 in human B-cell malignancies Blood 1993;82 (11):3430-3436 [PubMed]
  • Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression Cancer research 1993;53 (20):4754-4756 [PubMed]
  • Interaction through the LFA-1/ICAM-1 pathway prevents programmed cell death of germinal center B cells Advances in experimental medicine and biology 1993;329:387-392 [PubMed]
  • Met HIV samenhangend non-Hodgkin-lymfoom bij 45 patiënten; een retrospectieve analyse Nederlands tijdschrift voor geneeskunde 1993;137 (28):1396-1400 [PubMed]
  • Role of the CS1 adhesion motif of fibronectin in T cell adhesion to synovial membrane and peripheral lymph node endothelium Annals of the rheumatic diseases 1993;52 (9):672-676 [PubMed]
  • Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin Archives of dermatological research 1993;285 (4):179-183 [PubMed]

1992

  • Cellular interactions in the germinal center: role of adhesion receptors and significance for the pathogenesis of AIDS and malignant lymphoma Immunological reviews 1992;126:21-45 [PubMed]
  • Differential expression of the HECA-452 antigen (cutaneous lymphocyte associated antigen, CLA) in cutaneous and non-cutaneous T-cell lymphomas Histopathology 1992;21 (1):59-64 [PubMed]
  • Diffuse aggressive B-cell lymphomas of the gastrointestinal tract. An immunophenotypic and gene rearrangement analysis of 22 cases American journal of clinical pathology 1992;97 (2):170-178 [PubMed]
  • Een kind met Wegener's granulomatosis Tijdschrift voor kindergeneeskunde 1992;60 (2):52-56 [PubMed]
  • Induction of homotypic T cell adhesion by triggering of leukocyte function-associated antigen-1 alpha (CD11a): differential effects on resting and activated T cells European journal of immunology 1992;22 (7):1851-1856 [PubMed]
  • Progression of membranous glomerulopathy during cyclosporin A Clinical nephrology 1992;37 (6):314 [PubMed]
  • Protection from lethal graft-vs.-host disease by donor stem cell repopulation European journal of immunology 1992;22 (2):575-579 [PubMed]

1991

  • Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways Journal of experimental medicine 1991;173 (6):1297-1304 [PubMed]
  • Adhesion receptors involved in clustering of blood dendritic cells and T lymphocytes European journal of immunology 1991;21 (5):1101-1105 [PubMed]
  • Expression of 5'-nucleotidase (CD73) related to other differentiation antigens in leukemias of B-cell lineage Blood 1991;78 (2):488-492 [PubMed]
  • Expression of the human peripheral lymph node homing receptor (LECAM-1) in nodal and gastrointestinal non-Hodgkin's lymphomas Leukemia 1991;5 (7):628-631 [PubMed]
  • Expression of the leucocyte integrin LFA-1 (CD11a/CD18) and its ligand ICAM-1 (CD54) in lymphoid malignancies is related to lineage derivation and stage of differentiation but not to tumor grade Leukemia 1991;5 (10):848-853 [PubMed]
  • The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium Journal of immunology (Baltimore, Md. 1991;147 (12):4207-4210 [PubMed]

1990

  • Adhesion molecules in the prognosis of diffuse large-cell lymphoma: expression of a lymphocyte homing receptor (CD44), LFA-1 (CD11a/18), and ICAM-1 (CD54) Leukemia 1990;4 (8):595-599 [PubMed]
  • Dendritic cells and high endothelial venules in the rheumatoid synovial membrane Journal of rheumatology 1990;17 (1):11-17 [PubMed]
  • Expression of a human homing receptor (CD44) in lymphoid malignancies and related stages of lymphoid development Leukemia 1990;4 (5):383-389 [PubMed]
  • Expression of cell adhesion molecules in lymphoid malignancies Current problems in dermatology 1990;19:29-34 [PubMed]
  • Persistence of allospecific helper T cells is required for maintaining autoantibody formation in lupus-like graft-versus-host disease Clinical and experimental immunology 1990;82 (3):527-532 [PubMed]
  • The ontogeny of human lymphocyte recirculation: high endothelial cell antigen (HECA-452) and CD44 homing receptor expression in the development of the immune system European journal of immunology 1990;20 (7):1483-1489 [PubMed]
  • Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA-1 pathway Journal of immunology (Baltimore, Md. 1990;145 (11):3589-3593 [PubMed]

1989

  • Allosuppression of B cells in vitro by graft-vs.-host reaction-derived T cells is caused by cytotoxic T lymphocytes European journal of immunology 1989;19 (9):1669-1675 [PubMed]
  • Anti-high endothelial venule monoclonal antibody HECA-452 recognizes plasmacytoid T cells and delineates an "extranodular" compartment in the reactive lymph node Immunology letters 1989;20 (4):277-281 [PubMed]
  • Dendritic cells and scavenger macrophages in chronic inflammatory bowel disease Gut 1989;30 (4):484-491 [PubMed]
  • Expression of lymphocyte homing receptor as a mechanism of dissemination in non-Hodgkin's lymphoma Blood 1989;73 (4):885-888 [PubMed]
  • High endothelial venules present in lymphoid cell accumulations in thyroids affected by autoimmune disease: a study in men and BB rats of functional activity and development Journal of clinical endocrinology and metabolism 1989;68 (4):744-751 [PubMed]
  • Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor Journal of immunology (Baltimore, Md. 1989;143 (3):851-857 [PubMed]
  • Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease Immunological reviews 1989;108:111-133 [PubMed]
  • Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family Neuroscience letters 1989;101 (3):288-292 [PubMed]

1988

  • Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules Journal of immunology (Baltimore, Md. 1988;140 (6):1851-1853 [PubMed]
  • Expression and regulation of an antigen specific for endothelium involved in human lymphocyte homing Advances in experimental medicine and biology 1988;237:477-484 [PubMed]
  • High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452 American journal of pathology 1988;130 (1):147-155 [PubMed]
  • MEL-14 and LFA-1, organ specific and non-specific adhesion molecules involved in homing of human lymphocytes Advances in experimental medicine and biology 1988;237:505-509 [PubMed]

1986

  • Human lymphocyte-high endothelial venule interaction: organ-selective binding of T and B lymphocyte populations to high endothelium Journal of immunology (Baltimore, Md. 1986;137 (3):760-763 [PubMed]
  • Immunologic induction of malignant lymphoma: graft-vs-host reaction-induced B cell lymphomas contain integrations of predominantly ecotropic murine leukemia proviruses Journal of immunology (Baltimore, Md. 1986;136 (1):331-339 [PubMed]

1985

  • Chronic progressive polyarthritis and other symptoms of collagen vascular disease induced by graft-vs-host reaction Journal of immunology (Baltimore, Md. 1985;134 (3):1475-1482 [PubMed]

1984

  • Allosuppressor- and allohelper-T cells in acute and chronic graft-vs-host disease. IV. Activation of donor allosuppressor cells is confined to acute GVHD Journal of immunology (Baltimore, Md. 1984;132 (4):1669-1678 [PubMed]
  • Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. V. F1 mice with secondary chronic GVHD contain F1-reactive allohelper but no allosuppressor T cells Journal of experimental medicine 1984;159 (2):508-523 [PubMed]
  • Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases Immunology today 1984;5 (11):324-332 [PubMed]

1983

  • Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A Journal of experimental medicine 1983;157 (2):755-771 [PubMed]
  • A SEQUENTIAL ALLOACTIVATION OF SUBSETS OF DONOR T-CELLS UNDERLIES THE TRANSITION FROM ACUTE GRAFT-VERSUS-HOST DISEASE (GVHD) TO CHRONIC GVHD Transplantation proceedings 1983;15 (1):1480-1483
  • GRAFT-VERSUS-HOST REACTIONS (GVHRS) - CLUES TO THE PATHOGENESIS OF A BROAD-SPECTRUM OF IMMUNOLOGICAL DISEASES Transplantation proceedings 1983;15 (1):1436-1440
  • T cell-dependent B-cell proliferation and activation induced by administration of the drug diphenylhydantoin to mice Hematological oncology 1983;1 (2):165-176 [PubMed]

1982

  • Allosuppressor and allohelper T cells in acute and chronic graft-vs-host disease. I. Alloreactive suppressor cells rather than killer T cells appear to be the decisive effector cells in lethal graft-vs.-host disease Journal of experimental medicine 1982;155 (5):1501-1522 [PubMed]
  • Induction of either acute or chronic graft-versus-host disease due to genetic differences among donor T cells Advances in experimental medicine and biology 1982;149:537-544 [PubMed]
  • T cell-dependent B cell lymphoproliferation and activation induced by the drug diphenylhydantoin Advances in experimental medicine and biology 1982;149:617-622 [PubMed]

1977

  • Studies of bone and soft-tissue tumours induced in rats with radioactive cerium chloride International journal of cancer. Journal international du cancer 1977;20 (1):112-119 [PubMed]